US20040151751A1 - Calcium phosphate/sulphate-based bone implant composition - Google Patents

Calcium phosphate/sulphate-based bone implant composition Download PDF

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Publication number
US20040151751A1
US20040151751A1 US10/476,242 US47624204A US2004151751A1 US 20040151751 A1 US20040151751 A1 US 20040151751A1 US 47624204 A US47624204 A US 47624204A US 2004151751 A1 US2004151751 A1 US 2004151751A1
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composition according
calcium
composition
ions
source
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US10/476,242
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John Cooper
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Biocomposites Ltd
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Biocomposites Ltd
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Assigned to BIOCOMPOSITES LIMITED reassignment BIOCOMPOSITES LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: COOPER, JOHN JOSEPH
Publication of US20040151751A1 publication Critical patent/US20040151751A1/en
Priority to US12/356,357 priority Critical patent/US8632796B2/en
Priority to US13/241,999 priority patent/US8496955B2/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003Not used, see subgroups
    • A61C8/0004Consolidating natural teeth
    • A61C8/0006Periodontal tissue or bone regeneration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2817Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2835Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006Properties of materials and coating materials
    • A61F2002/30062(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00179Ceramics or ceramic-like structures
    • A61F2310/00293Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406Antibiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62Encapsulated active agents, e.g. emulsified droplets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • This invention concerns a bone implant composition, and a method of forming a bone graft.
  • the bone graft material of preferred choice is autograft, i.e. the patients own bone, since this is totally biocompatible, is not subject to an immune response or disease transmission and has good osteogenic capacity.
  • autograft i.e. the patients own bone, since this is totally biocompatible, is not subject to an immune response or disease transmission and has good osteogenic capacity.
  • its source is limited, it requires a second surgical procedure for harvest and there are often donor site morbidity problems.
  • Allograft bone is usually considered an acceptable alternative since it is more readily available and has a reasonable level of efficacy. However, it has the potential for disease transmission and since it is ‘foreign’ tissue there is the potential for immunological reactions. In addition, it is a material variable in its properties, due to donor source (often elderly people with osteoporotic bones) and processing variability. This makes prediction of clinical outcome difficult when allograft is used. Delayed healing is a frequent complication.
  • a bone implant composition comprising calcium sulphate and slowly soluble sources of calcium, orthophosphate and hydroxyl ions.
  • the source of the ions is preferably provided by compounds which are slowly soluble in water, and preferably compounds where the water solubility at room temperature is less than 5 g per litre, desirably less than 1 g per litre, and more desirably less than 0.1 g per litre.
  • the source of the calcium ions may be the calcium sulphate alone, or may be provided by one or more of: calcium carbonate, calcium phosphate, calcium oxide, calcium fluoride, calcium citrate, calcium stearate, or dolomite.
  • the calcium sulphate may be in the form of dihydrate, hemi-hydrate, soluble anhydrite or insoluble anhydrite.
  • the ratio of calcium sulphate to all other compounds in the composition is preferably between 0.2 and 2 parts by weight.
  • the composition may also comprise a medicament, and desirably in an effective therapeutic amount.
  • the medicament may comprise any of: an antibiotic, an anti-cancer agent, or bone morphogenic protein.
  • the source of orthophosphate ions may be one or more of: hydroxyapatite, alpha tricalcium phosphate, beta tricalcium phosphate, dicalcium phosphate, tetracalcium phosphate or magnesium orthophosphate.
  • the source of orthophosphate ions may be in the form of a micro-porous granular solid.
  • the granules may have a particle size in the range 0.2-5.00 mm.
  • the source of orthophosphate may be in the form of a micro-porous granular solid component.
  • the source of the hydroxyl ions may be one or more of: calcium oxide, insoluble anhydrite, calcium hydroxide, magnesium oxide, magnesium hydroxide, zinc oxide, zinc hydroxide, or basic magnesium carbonate.
  • the ratio of basicity to orthophosphate is preferably between 0.0 and 1.0 molar.
  • the composition may be in the form of a powder which can be mixed with water or an aqueous solution to form a usable paste.
  • the composition may be in the form of granules or pellets.
  • the composition may be formed into pellets using a tablet press.
  • the invention also provides a method of forming a bone graft, the method comprising using a bone implant composition according to any of the preceding ten paragraphs.
  • the composition When in powder form the composition may be mixed with water or an aqueous solution to form a putty or paste prior to application.
  • the putty or paste may be applied to a surgical site by a suitable applicator such as a syringe.
  • the putty or paste may be applied to a mould and allowed to set prior to presentation to the surgical site.
  • composition is in the form of granules or pellets
  • the granules or pellets can be packed into a bone cavity.
  • a powdered mixture was prepared according to the following composition:—
  • the beta tricalcium phosphate particles have a size of 250-500 microns.
  • a powdered mixture was prepared according to the following composition:—
  • beta tricalcium phosphate granules with a particle size of 1-2 mm diameter.
  • the mixture was pressed into pellets 3 mm diameter by 2.5 mm deep using a tablet press.
  • the pellets were used to fill a bone cavity.
  • a powdered mixture was prepared according to the following composition:—
  • a powdered mixture was prepared according to the following composition:—
  • the beta tricalcium phosphate particles have a size range of 1-2 mm.
  • the mixture was blended with 9.5 ml of water and compacted into 6 mm diameter cylindrical moulds where it was allowed to set. The set pellets were removed from the moulds and allowed to dry. These were used to fill a bone cavity.
  • a powdered mixture was prepared according to the previous example (Example 4), but including 5% by weight of the antibiotic gentamycin which was added to the powdered mix prior to moulding.
  • the composition provides a source of ions which precipitate in vivo to provide a poorly crystalline, substituted apatite which closely mimics the natural mineral phase of bone, in contrast to other presently available synthetic bone graft substitutes. Also, the reaction occurs over a time frame commensurate with the body's ability to regenerate new healthy bone. This precipitated hydroxyapatite is amenable to osteoclastic resorption.
  • the calcium sulphate phase initially present resorbs by a simple dissolution mechanism over a period of a few weeks to provide a macroporous structure amenable to vascularisation and invasion by new bony tissue. The calcium sulphate forms a micro-porous barrier which prevents intrusion of unwanted soft tissue (cells) in the immediate post implantation period.
  • the source of ortho phosphate is preferably a micro-porous granular solid, with a mincee size of 0.2-5 mm. This size range provides for an intergranule pore size of 100-200 microns which is necessary for cell infiltration and vascularization to stimulate new bone in-growth.
  • the calcium ions may be obtained from the calcium sulphate alone, or may also be obtained from calcium stearate as in Example 2, or other calcium compounds such as calcium carbonate, calcium phosphate, calcium oxide, calcium fluoride, calcium citrate or dolomite.
  • the orthophosphate ions may be provided by beta tricalcium phosphate, these ions may be provided by hydroxyapatite, alpha tricalcium phosphate, dicalcium phosphate, tetracalcium phosphate or magnesium orthophosphate.
  • the source of hydroxyl ions is magnesium oxide, and also zinc oxide in Example 3. These ions may though additionally or as an alternative be obtained from calcium oxide, insoluble anhydrite, calcium hydroxide, magnesium hydroxide, zinc hydroxide or basic magnesium carbonate. As illustrated in the Examples, the calcium sulphate may be in one or more of the following forms:— alpha hemihydrate, beta hemihydrate, soluble anhydrite, insoluble anhydrite or dihydrate.
  • composition may comprise a medicament in an effective therapeutic amount, which medicament may comprise an antibiotic, an anti-cancer agent, or bone morphogenic protein.

Abstract

A bone implant composition, the composition comprising calcium sulphate and slowly soluble sources of calcium, orthophosphate and hydroxyl ions. The composition may be provided in powder or granulated form.

Description

  • This invention concerns a bone implant composition, and a method of forming a bone graft. [0001]
  • In orthopaedic and dental surgical applications there is a great need for biocompatible and bioresorbable implant material which can be conveniently and effectively used as a bone substitute. This includes bone lost due to periodontal disease, ridge augmentation, sinus elevation, bone defects or cavities due to trauma, disease or surgery and spinal fusions. Following implantation the bone substitute is ideally resorbed in a time frame which is consistent with its replacement by new vital bone. [0002]
  • The bone graft material of preferred choice is autograft, i.e. the patients own bone, since this is totally biocompatible, is not subject to an immune response or disease transmission and has good osteogenic capacity. However, its source is limited, it requires a second surgical procedure for harvest and there are often donor site morbidity problems. [0003]
  • Allograft bone is usually considered an acceptable alternative since it is more readily available and has a reasonable level of efficacy. However, it has the potential for disease transmission and since it is ‘foreign’ tissue there is the potential for immunological reactions. In addition, it is a material variable in its properties, due to donor source (often elderly people with osteoporotic bones) and processing variability. This makes prediction of clinical outcome difficult when allograft is used. Delayed healing is a frequent complication. [0004]
  • According to the present invention there is provided a bone implant composition, the composition comprising calcium sulphate and slowly soluble sources of calcium, orthophosphate and hydroxyl ions. [0005]
  • The source of the ions is preferably provided by compounds which are slowly soluble in water, and preferably compounds where the water solubility at room temperature is less than 5 g per litre, desirably less than 1 g per litre, and more desirably less than 0.1 g per litre. [0006]
  • The source of the calcium ions may be the calcium sulphate alone, or may be provided by one or more of: calcium carbonate, calcium phosphate, calcium oxide, calcium fluoride, calcium citrate, calcium stearate, or dolomite. [0007]
  • The calcium sulphate may be in the form of dihydrate, hemi-hydrate, soluble anhydrite or insoluble anhydrite. The ratio of calcium sulphate to all other compounds in the composition is preferably between 0.2 and 2 parts by weight. [0008]
  • The composition may also comprise a medicament, and desirably in an effective therapeutic amount. The medicament may comprise any of: an antibiotic, an anti-cancer agent, or bone morphogenic protein. [0009]
  • The source of orthophosphate ions may be one or more of: hydroxyapatite, alpha tricalcium phosphate, beta tricalcium phosphate, dicalcium phosphate, tetracalcium phosphate or magnesium orthophosphate. The source of orthophosphate ions may be in the form of a micro-porous granular solid. The granules may have a particle size in the range 0.2-5.00 mm. The source of orthophosphate may be in the form of a micro-porous granular solid component. [0010]
  • The source of the hydroxyl ions may be one or more of: calcium oxide, insoluble anhydrite, calcium hydroxide, magnesium oxide, magnesium hydroxide, zinc oxide, zinc hydroxide, or basic magnesium carbonate. [0011]
  • In the composition the ratio of basicity to orthophosphate is preferably between 0.0 and 1.0 molar. [0012]
  • The composition may be in the form of a powder which can be mixed with water or an aqueous solution to form a usable paste. [0013]
  • Alternatively, the composition may be in the form of granules or pellets. The composition may be formed into pellets using a tablet press. [0014]
  • The invention also provides a method of forming a bone graft, the method comprising using a bone implant composition according to any of the preceding ten paragraphs. [0015]
  • When in powder form the composition may be mixed with water or an aqueous solution to form a putty or paste prior to application. The putty or paste may be applied to a surgical site by a suitable applicator such as a syringe. Alternatively the putty or paste may be applied to a mould and allowed to set prior to presentation to the surgical site. [0016]
  • Where the composition is in the form of granules or pellets, the granules or pellets can be packed into a bone cavity. [0017]
  • Embodiments of the present invention will now be described by way of example only.[0018]
  • EXAMPLE 1
  • A powdered mixture was prepared according to the following composition:—[0019]
  • 1.25 g beta tricalcium phosphate [0020]
  • 0.63 g calcium sulphate alpha hemihydrate [0021]
  • 0.05 g magnesium oxide [0022]
  • The beta tricalcium phosphate particles have a size of 250-500 microns. [0023]
  • The mixture was blended with 0.85 ml of a 1% potassium sulphate solution to give a paste which was used to fill a periodontal pocket. [0024]
  • EXAMPLE 2
  • A powdered mixture was prepared according to the following composition:—[0025]
  • 35.0 g beta tricalcium phosphate granules with a particle size of 1-2 mm diameter. [0026]
  • 17.5 g calcium sulphate dihydrate [0027]
  • 2.2 g magnesium oxide [0028]
  • 0.80 g calcium stearate [0029]
  • The mixture was pressed into pellets 3 mm diameter by 2.5 mm deep using a tablet press. The pellets were used to fill a bone cavity. [0030]
  • EXAMPLE 3
  • A powdered mixture was prepared according to the following composition:—[0031]
  • 35.0 g alpha tricalcium phosphate [0032]
  • 14.0 g anhydrous calcium sulphate-insoluble form [0033]
  • 10.0 g basic magnesium carbonate [0034]
  • 0.1 g zinc oxide [0035]
  • The mixture was pressed into pellets using a tablet press. [0036]
  • EXAMPLE 4
  • A powdered mixture was prepared according to the following composition:—[0037]
  • 10.0 g beta tricalcium phosphate particles [0038]
  • 5.0 g calcium sulphate alpha hemihydrate powder [0039]
  • 0.5 g magnesium oxide [0040]
  • The beta tricalcium phosphate particles have a size range of 1-2 mm. [0041]
  • The mixture was blended with 9.5 ml of water and compacted into 6 mm diameter cylindrical moulds where it was allowed to set. The set pellets were removed from the moulds and allowed to dry. These were used to fill a bone cavity. [0042]
  • EXAMPLE 5
  • A powdered mixture was prepared according to the previous example (Example 4), but including 5% by weight of the antibiotic gentamycin which was added to the powdered mix prior to moulding. [0043]
  • There is thus described a bone implant composition and a method of using same which provides for considerable advantages. The composition is based upon the following chemical equation:—[0044]
  • 10Ca2++6PO4 3−+2OH=Ca10(PO4)6(OH)2
  • The composition provides a source of ions which precipitate in vivo to provide a poorly crystalline, substituted apatite which closely mimics the natural mineral phase of bone, in contrast to other presently available synthetic bone graft substitutes. Also, the reaction occurs over a time frame commensurate with the body's ability to regenerate new healthy bone. This precipitated hydroxyapatite is amenable to osteoclastic resorption. The calcium sulphate phase initially present resorbs by a simple dissolution mechanism over a period of a few weeks to provide a macroporous structure amenable to vascularisation and invasion by new bony tissue. The calcium sulphate forms a micro-porous barrier which prevents intrusion of unwanted soft tissue (cells) in the immediate post implantation period. [0045]
  • The source of ortho phosphate is preferably a micro-porous granular solid, with a partide size of 0.2-5 mm. This size range provides for an intergranule pore size of 100-200 microns which is necessary for cell infiltration and vascularization to stimulate new bone in-growth. [0046]
  • Various modifications may be made without departing from the scope of the invention. The calcium ions may be obtained from the calcium sulphate alone, or may also be obtained from calcium stearate as in Example 2, or other calcium compounds such as calcium carbonate, calcium phosphate, calcium oxide, calcium fluoride, calcium citrate or dolomite. In addition or as an alternative to the orthophosphate ions being provided by beta tricalcium phosphate, these ions may be provided by hydroxyapatite, alpha tricalcium phosphate, dicalcium phosphate, tetracalcium phosphate or magnesium orthophosphate. [0047]
  • In the examples the source of hydroxyl ions is magnesium oxide, and also zinc oxide in Example 3. These ions may though additionally or as an alternative be obtained from calcium oxide, insoluble anhydrite, calcium hydroxide, magnesium hydroxide, zinc hydroxide or basic magnesium carbonate. As illustrated in the Examples, the calcium sulphate may be in one or more of the following forms:— alpha hemihydrate, beta hemihydrate, soluble anhydrite, insoluble anhydrite or dihydrate. [0048]
  • The composition may comprise a medicament in an effective therapeutic amount, which medicament may comprise an antibiotic, an anti-cancer agent, or bone morphogenic protein. [0049]
  • Whilst endeavouring in the foregoing specification to draw attention to those features of the invention believed to be of particular importance it should be understood that the Applicant claims protection in respect of any patentable feature or combination of features hereinbefore referred to and/or shown in the drawings whether or not particular emphasis has been placed thereon. [0050]

Claims (26)

1. A bone implant composition characterised in that the composition comprises calcium sulphate and slowly soluble sources of calcium, orthophosphate and hydroxyl ions.
2. A composition according to claim 1, characterised in that the source of the ions is provided by compounds which are slowly soluble in water.
3. A composition according to claim 2, characterised in that water solubility of the compounds at room temperature is less than 5 g per litre.
4. A composition according to claim 3, characterised in that water solubility of the compounds at room temperature is less than 1 g per litre.
5. A composition according to claim 4, characterised in that water solubility of the compounds at room temperature is less than 0.1 g per litre.
6. A composition according to any of the preceding claims, characterised in that the source of the calcium ions is the calcium sulphate alone.
7. A composition according to any of claims 1 to 5, characterised in that the source of the calcium ions is provided by one or more of: calcium carbonate, calcium phosphate, calcium oxide, calcium fluoride, calcium citrate, calcium stearate, or dolomite.
8. A composition according to any of the preceding claims, characterised in that the calcium sulphate is in the form of dehydrate, hemi-hydrate, soluble anhydrite or insoluble anhydrite.
9. A composition according to any of the preceding claims, characterised in that the ratio of calcium sulphate to all other compounds in the composition is between 0.2 and 2 parts by weight.
10. A composition according to any of the preceding claims, characterised in that the composition comprises a medicament.
11. A composition according to claim 10, characterised in that the medicament is in an effective therapeutic amount.
12. A composition according to claim 10 or claim 11, characterised in that the medicament comprises any of: an antibiotic, an anti-cancer agent, or bone morphogenic protein.
13. A composition according to any of the preceding claims, characterised in that the source of orthophosphate ions is one or more of: hydroxyapatite, alpha tricalcium phosphate, beta tricalcium phosphate, dicalcium phosphate, tetracalcium phosphate or magnesium orthophosphate.
14. A composition according to any of the preceding claims, characterised in that the source of orthophosphate ions is in the form of a micro-porous granular solid.
15. A composition according to claim 14, characterised in that the granules have a particle size in the range 0.2-5.00 mm.
16. A composition according to any of the preceding claims, characterised in that the source of the hydroxyl ions may be one or more of: calcium oxide, insoluble anhydrite, calcium hydroxide, magnesium oxide, magnesium hydroxide, zinc oxide, zinc hydroxide, or basic magnesium carbonate.
17. A composition according to any of the preceding claims, characterised in that in the composition the ratio of basicity to orthophosphate is between 0.0 and 1.0 molar.
18. A composition according to any of the preceding claims, characterised in that the composition is in the form of a powder which can be mixed with water or an aqueous solution to form a usable paste.
19. A composition according to any of claims 1 to 17, characterised in that the composition is in the form of granules or pellets.
20. A composition according to claim 19, characterised in that the composition is formed into pellets using a tablet press.
21. A method of forming a bone graft, characterised in that the method comprises using a bone implant composition according to any of the preceding claims.
22. A method according to claim 21 when dependent on claim 18, characterised in that when in powder form the composition is mixed with water or an aqueous solution to form a putty or paste prior to application.
23. A method according to claim 22, characterised in that the putty or paste is applied to a surgical site by a suitable applicator such as a syringe.
24. A method according to claim 22, characterised in that the putty or paste is applied to a mould and allowed to set prior to presentation to the surgical site.
25. A method according to claim 21 when dependent on claim 19 or claim 20, characterised in that when the composition is in the form of granules or pellets, the granules or pellets can be packed into a bone cavity.
26. Any novel subject matter or combination including novel subject matter disclosed herein, whether or not within the scope of or relating to the same invention as any of the preceding claims.
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US20030161858A1 (en) * 2000-04-11 2003-08-28 Lars Lidgren Injectable bone mineral substitute material
US20040048947A1 (en) * 2000-07-17 2004-03-11 Lars Lidgren Composition for an injectable bone mineral substitute material
US20050119746A1 (en) * 2001-12-20 2005-06-02 Lars Lidgren Bone mineral substitute
US20070041906A1 (en) * 2003-03-05 2007-02-22 Lars Lidgren Bone substitute composition
US20070161943A1 (en) * 2003-11-11 2007-07-12 Lars Lidgren Device for providing spongy bone with bone substitute and/or bone reinforcing material, bone substitute and/or bone reinforcing material and method
US20070217282A1 (en) * 2004-06-22 2007-09-20 Bone Support Ab Device for Producing a Hardenable Mass
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US20080020349A1 (en) * 2005-02-24 2008-01-24 Roland Dricot Bone implant
US20090022811A1 (en) * 2007-03-07 2009-01-22 Legeros Racquel Z Mineralized guided bone regeneration membranes and methods of making the same
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US20140314849A1 (en) * 2013-04-18 2014-10-23 Novagenit S.R.L. Method for preparing biocompatible and biodegradable biomaterials based on collagen and granules of hydroxyapatite/beta-tricalcium phosphate for use in surgery, and biomaterials thus obtained
US20140335197A1 (en) * 2013-05-10 2014-11-13 Reed A. Ayers Combustion synthesis of calcium phosphate constructs and powders doped with atoms, molecules, ions, or compounds
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778471A (en) * 1986-11-19 1988-10-18 University Of Dayton Zcap ceramics
US5824087A (en) * 1994-04-11 1998-10-20 Aberdeen University And Plasma Biotal Limited Bone regeneration
US20010032022A1 (en) * 1998-11-06 2001-10-18 Ricci John L. Surgical implant system,article and kit

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2529613B2 (en) 1990-03-09 1996-08-28 学校法人松本歯科大学 Curable composition
US5149368A (en) * 1991-01-10 1992-09-22 Liu Sung Tsuen Resorbable bioactive calcium phosphate cement
CA2119090A1 (en) 1993-03-26 1994-09-27 Wayne R. Gombotz Compositions for controlled release of biologically active tgf-.beta.
JPH078548A (en) 1993-06-24 1995-01-13 Mitsui Toatsu Chem Inc Hardenable powder for living body
AU3795395A (en) * 1994-11-30 1996-06-06 Ethicon Inc. Hard tissue bone cements and substitutes
DE19853832A1 (en) 1998-11-21 2000-05-25 Merck Patent Gmbh Calcium phosphate cements containing polyalkenoic acids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778471A (en) * 1986-11-19 1988-10-18 University Of Dayton Zcap ceramics
US5824087A (en) * 1994-04-11 1998-10-20 Aberdeen University And Plasma Biotal Limited Bone regeneration
US20010032022A1 (en) * 1998-11-06 2001-10-18 Ricci John L. Surgical implant system,article and kit

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US20030161858A1 (en) * 2000-04-11 2003-08-28 Lars Lidgren Injectable bone mineral substitute material
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