US20040210226A1 - Anchoring devices and implants for intervertebral disc augmentation - Google Patents
Anchoring devices and implants for intervertebral disc augmentation Download PDFInfo
- Publication number
- US20040210226A1 US20040210226A1 US10/842,103 US84210304A US2004210226A1 US 20040210226 A1 US20040210226 A1 US 20040210226A1 US 84210304 A US84210304 A US 84210304A US 2004210226 A1 US2004210226 A1 US 2004210226A1
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- United States
- Prior art keywords
- anchoring
- implant
- rod
- implants
- securable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00928—Coating or prosthesis-covering structure made of glass or of glass-containing compounds, e.g. of bioglass
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
- Y10S606/91—Polymer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
- Y10S606/911—Memory material
Abstract
Devices for anchoring spinal implants in an intervertebral disc space are provided. Spinal implants are also provided that are resistant to lateral deformation. The implants may include a flexible peripheral supporting band disposed circumferentially about an elastic body. Methods for anchoring spinal implants and methods for reducing deformation of spinal implants are also provided.
Description
- The present invention relates to spinal implants, devices for anchoring, and methods for implantation of, such implants in an intervertebral disc space.
- The intervertebral disc functions to stabilize the spine and to distribute forces between vertebral bodies. A normal disc includes a gelatinous nucleus pulposus, an annulus fibrosis and two vertebral end plates. The nucleus pulposus is surrounded and confined by the annulus fibrosis.
- Intervertebral discs may be displaced or damaged due to trauma or disease. Disruption of the annulus fibrosis allows the nucleus pulposus to protrude into the spinal canal, a condition commonly referred to as a herniated or ruptured disc. The extruded nucleus pulposus may press on the spinal nerve, which may result in nerve damage, pain, numbness, muscle weakness and paralysis. Intervertebral discs may also deteriorate due to the normal aging process. As a disc dehydrates and hardens, the disc space height will be reduced, leading to instability of the spine, decreased mobility and pain.
- One way to relieve the symptoms of these conditions is by surgical removal of a portion or all of the intervertebral disc. The removal of the damaged or unhealthy disc may allow the disc space to collapse, which could lead to instability of the spine, abnormal joint mechanics, nerve damage, as well as severe pain. Therefore, after removal of the disc, adjacent vertebrae are typically fused to preserve the disc space.
- Several devices exist to fill an intervertebral space following removal of all or part of the intervertebral disc in order to prevent disc space collapse and to promote fusion of adjacent vertebrae surrounding the disc space. Even though a certain degree of success with these devices has been achieved, full motion is typically never regained after such intervertebral fusions. Attempts to overcome these problems has led to the development of disc replacements. Many of these devices are complicated, bulky and made of a combination of metallic and elastomeric components and thus never fully return the full range of motion desired. More recently, efforts have been directed to replacing the nucleus pulposus of the disc with a similar gelatinous material, such as a hydrogel. However, once positioned in the disc space, many hydrogel implants may migrate in the disc space and/or may be expelled from the disc space through an annular defect. Closure of the annular defect, or other opening, using surgical sutures or staples following implantion is typically difficult and, in some cases, ineffective. Moreover, such hydrogel implants may be subject to extensive deformation. Additionally, such hydrogel implants typically lack mechanical strength at high water content and are therefore more prone to excessive deformation, creep, cracking, tearing or other damage under fatigue loading conditions.
- A need therefore exists for more durable nucleus pulposus or other spinal implants, including implants that are less resistant to deformation, as well as devices and methods that anchor the implants so that the implants are more resistant to migration and/or expulsion through an opening in the annulus fibrosis. The present invention addresses these needs.
- Devices for anchoring a spinal implant in an intervertebral disc space are provided. In one form of the invention, a device includes an elongated anchoring body, such as an anchoring rod, and at least one securing member attached to the anchoring rod. The anchoring body or rod is configured to anchor, hold, or otherwise retain a spinal implant. In certain forms of the invention wherein more than one securing member is included, the securing members are spaced apart along the length of the anchoring rod and may define a region for disposing an implant therebetween. The anchoring rod has a first end and a second end, wherein the first end is securable to an adjacent vertebra. The anchoring devices may be made from metallic materials, non-metallic materials and combinations thereof.
- Spinal implant systems are also provided that include the anchoring device described above and an elastic spinal implant. In certain forms of the invention, the anchoring devices include an anchoring rod and at least one securing member attached to the anchoring rod. The anchoring rod includes a first end, a second end, a longitudinal axis and extends at least partially through the implant. The anchoring component is securable to an adjacent vertebra. In one form of the invention, the securing members may be external to the implant, while in other forms of the invention the securing members may be internal to the implant or may be both internal and external to the implant.
- Spinal implants are also provided that are resistant to lateral deformation as they are restrained, or otherwise reinforced, by a flexible, peripheral supporting band. In one form of the invention, the implant includes an elastic body sized for introduction into the intervertebral disc space. The elastic body includes an upper surface and a lower surface for contacting adjacent vertebral endplates. A flexible peripheral supporting band is disposed circumferentially about the elastic body to reduce deformation of the body. At least a portion of the upper and lower surfaces of the elastic body are free of the supporting band. The implant, including the band, is sized to fit within an intervertebral disc space which is at least partially defined by an annulus fibrosis.
- Methods of anchoring a spinal implant are also provided. A preferred method includes providing an elastic spinal implant and an anchoring component that includes the anchoring devices described above, extending the anchoring rod of the device at least partially through the implant, and securing the anchoring component to an adjacent vertebra.
- Methods of reducing deformation of a spinal implant are also provided. In one embodiment, a method includes disposing a flexible peripheral supporting band circumferentially about the implants described above.
- One object of the present invention is to provide devices for anchoring spinal implants so they will be resistant to excessive migration in, and/or expulsion from, the intervertebral disc space.
- Yet another object of the invention is to provide spinal implant systems including an elastic spinal implant and an anchoring component for anchoring the implant.
- A further object of the invention is to provide spinal implants that are more resistant to lateral deformation.
- These and other objects and advantages of the present invention will be apparent from the descriptions herein.
- FIG. 1 is a side view of a device for anchoring a spinal implant in an intervertebral disc space.
- FIG. 2 is an end view of the device of FIG. 1, taken along line2-2.
- FIG. 3 is a side view of an alternative embodiment of a device for anchoring a spinal implant in an intervertebral disc space, having a ball-and-socket joint.
- FIG. 4 is a perspective view of the device of FIG. 3.
- FIG. 5 depicts a side view of an alternative embodiment of a device for anchoring a spinal implant in an intervertebral disc space.
- FIG. 6 is an end view of the device of FIG. 5, taken along line6-6.
- FIGS. 7A-7T depict top views of alternative embodiments of securing members of the anchoring devices described herein. The anchoring members are shown with a superimposed outline of how an implant I may be disposed on the anchoring device.
- FIGS. 8A-8H depict top views of further alternative embodiments of securing members of the anchoring devices described herein. The anchoring members are shown with a superimposed outline of how an implant I may be disposed on the anchoring device.
- FIG. 9 is a side view of a spinal implant system.
- FIG. 10 depicts an end view of the system of FIG. 9, taken along line10-10.
- FIG. 11 depicts a side view of the spinal implant system of FIG. 9, implanted in an intervertebral disc space, that includes an
anchoring component 10, anelastic body 100 and, optionally, a peripheral supportingband 101. - FIG. 12 depicts a side view of an alternative embodiment of a spinal implant system.
- FIG. 13 depicts an end view of the system of FIG. 12, taken along line13-13.
- FIG. 14 depicts a side view of the system of FIG. 12 implanted in an intervertebral disc space.
- FIG. 15A depicts a perspective view of a spinal implant that may be anchored with the anchoring devices described herein.
- FIG. 15B depicts a side view of the implant of FIG. 15A.
- FIG. 16 is a side view of a spinal implant reinforced with a flexible peripheral supporting band.
- FIG. 17 depicts a top view of the implant of FIG. 16.
- FIG. 18A shows the effect of imposing a load, represented by the darkened arrows, on the deformation of a spinal implant reinforced with a flexible supporting band. Top to bottom: no load; low load, moderate load; high load.
- FIG. 18B is a graphical representation of the effect of imposing a load on the deformation of a spinal implant of FIG. 18A.
- FIGS. 19A-19D depict alternative embodiments of a flexible peripheral supporting band of the present invention.
- FIG. 20 depicts a side view of a spinal implant of the present invention that is reinforced, and otherwise supported, by peripheral supporting
band 130′ and straps 134 and 135. - FIG. 21 shows a top view of the implant of FIG. 20.
- FIG. 22 depicts a side view of an alternative embodiment of a spinal implant of the present invention, that includes a peripheral supporting
band 130″ and securingstraps 134′, 135′, 820, 830, 840 and 850. - FIG. 23 depicts a top view of the implant of FIG. 22.
- FIG. 24 shows a cut-away view of an alternative embodiment of an anchoring device implanted in an intervertebral disc space for anchoring
implant 100 with atension band 700 extending betweenvertebrae - FIG. 25 depicts a side view of the device of FIG. 24.
- FIG. 26 depicts a top, cut-away view of an alternative embodiment of a device for anchoring a spinal implant that is implanted in an intervertebral disc space.
- FIG. 27 shows a top, cut-away view of an alternative embodiment of a device for anchoring a spinal implant that is implanted in an intervertebral disc space.
- FIGS. 28-31 depicts cut-away, top views of anchoring devices, along with anchored implants, inserted via posterior, lateral, oblique and anterior approaches, respectively.
- FIG. 32 depicts a top, cut-away view of a device for anchoring a spinal implant that is implanted in an intervertebral disc space, wherein two implants are advantageously anchored.
- FIG. 33 depicts a top, cut-away view of an alternative embodiment of a device for anchoring a spinal implant, wherein two devices are used to anchor two spinal implants.
- For the purposes of promoting an understanding of the principles of the invention, reference will now be made to preferred embodiments and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, such alterations and further modifications of the invention, and such further applications of the principles of the invention as illustrated herein, being contemplated as would normally occur to one skilled in the art to which the invention relates.
- The present invention relates to devices for anchoring a spinal implant in an intervertebral disc space to prevent excessive migration in and/or expulsion from the disc space, as well as novel spinal implants. Spinal implant systems are also described that include the anchoring device as well as an anchored elastic spinal implant. The spinal implants described herein include those that may be useful as nucleus pulposus replacements, partial or complete disc replacements, and those that may be useful in other disc reconstruction or augmentation procedures.
- In other aspects of the invention, spinal implants are provided that include an elastic body that is constrained and supported by a flexible supporting member, such as a peripheral supporting band. The band may advantageously have high resistance to hoop stress, and may thus function in a similar manner as the annulus fibrosis. More particularly, the hoop stress in the band preferably increases exponentially after some small, allowable initial deformation. Such implants may advantageously be used where the integrity of the annulus fibrosis has been negatively affected, or in other circumstances wherein increased support of an implant is needed.
- In one aspect of the invention, a device for anchoring a spinal implant in an intervertebral disc space is provided. The device may include an elongated anchoring body, such as an anchoring rod, having at least one securing member attached thereto, or otherwise disposed thereon. Referring now to FIGS. 1 and 2, anchoring
device 10 may include an elongated anchoring body, or rod, 20, first securingmember 30 and second securingmember 40. Securingmembers rod 20 and may define a region R for disposing a spinal implant therebetween. Moreover, the longitudinal axes A of the securing members preferably extend transverse with respect to the longitudinal axis X of the anchoring rod. The device may advantageously be secured to an adjacent vertebra. - For example, in one form of the invention, anchoring
device 10 includes afirst end 21 and asecond end 22, whereinfirst end 21 is securable to an adjacent vertebra. First end 21 may define abracket 23, or other similar structure, for securingfirst end 21 to an adjacent vertebra.Bracket 23 includes a vertebra-contactingsurface 24 and at least oneaperture 25 through which a bone screw, or other similar securing device, may be placed to secure the elongated body to an adjacent vertebra as more fully described below. Moreover, a screw securing mechanism, such as a lock screw or other known mechanism, may be used to further secure the screw so it will not back out, or otherwise loosen.Bracket 23 is shown as generally V-shaped in FIG. 2, although a wide variety of other shapes are contemplated, as long asfirst end 21 is securable in some form to an adjacent vertebra. As seen in FIG. 2,bracket 23 includesarm 23 a andarm 23 b.Arms first end 21 may define a bracket that extends along the length of two adjacent vertebrae, so that the bracket may be secured both to an upper adjacent vertebra and to a lower adjacent vertebra in order to more stablysecure anchoring rod 20, and ultimately to more stably secure a spinal implant. - In another form of the invention, the bracket described herein may be mounted on, or otherwise connected to,
first end 21. For example, as shown in FIGS. 3 and 4,first end 21′ of anchoringrod 20′ may define a ball or other spherical-shaped end that fits in asocket 26 onbracket 23′ to form a ball-and-socket joint, or ball joint. The ball joint advantageously allows further movement of the attached elongated body of anchoringdevice 10′, which may reduce or eliminate stress that may otherwise exist near end E′ of the elongated body. - Anchoring
rod 20 may be formed from rigid, or otherwise non-flexible materials, including carbon fiber reinforced composite, such as carbon fiber/epoxy composites or carbon fiber/polyaryletherketone composites. Anchoringrod 20 may further be formed from a wide variety of metallic materials, including, for example, shape memory materials, stainless steel, titanium, titanium alloys, cobalt chrome alloys, and combinations thereof. The shape memory materials may be made from, for example, the nickel-titanium alloy known as Nitinol. The response of the shape memory material to deformation generally has two triggers as known in the art to induce the material to partially or fully recover its memorized shape. The first trigger is a thermal trigger where the deformed state is initially at a temperature such that the deformed state is stable. Upon heating, the temperature rises until the deformed state is no longer stable and begins to change to the memorized state. The second trigger is a stress-actuated trigger and may take advantage of superelasticity. The undeformed state is at a temperature such that at least some of the material is in the austenitic state. That is, the temperature may be such that the material is within the hysterisis loop responsible for the superelastic phenomenon or behavior. Under the influence of sufficient stress, the austenitic material will transform into the martensitic state. Upon the release of some or all of the stress, the temperature is such that the martensitic state is unstable and will automatically attempt to revert to the austenitic state with consequent shape reformation. It should also be understood that the shape memory material may attempt to recover the memorized shape by using some combination of thermal and stress actuation. Preferred shape memory materials will exhibit superelastic behavior. In devices formed from such rigid materials, anchoringrod 20 preferably includes an end E having an arcuate shape, as seen in FIG. 1, so thatelongated body 20 may be secured to an adjacent vertebra. - The anchoring rod component of the device may also, in other forms of the invention, be formed of flexible materials so that the anchoring rod acts as a tether, or other flexible anchor. Such a flexible, anchoring rod component of an
anchoring device 50 is shown in FIGS. 5 and 6. Flexible, anchoringrod 60 also includes a first securingmember 70 and a second securingmember 80. Anchoringrod 60 further includes afirst end 61 and asecond end 62, wherein the first end is securable to an adjacent vertebra. First end 61 may also define a bracket, such asbracket 23 as described above. First end 61 of anchoringrod 60 may also be mounted, or otherwise attached, tobracket 23′ through a ball-and-socket joint as described above by modifyingfirst end 61 appropriately. In preferred forms of the invention,first end 61 may be secured to an adjacent vertebra with an interference screw, especially when the device is implanted via a posterior approach as discussed below. Securingmembers rod 20 is shown as being cylindrical herein, it is realized that the rods described herein may assume a wide variety of shapes as known in the art, including pyramidal, square and other polygonal shapes. The shapes of the rods may be advantageously chosen so that the rods are effective in anchoring the implants described herein. - A wide variety of materials may be used to form
flexible anchoring rod 60, including the same materials that may be used to form a rigid anchoring rod described above, although the thickness or diameter of the rod will be smaller than with the rigid rod so that the rod will be flexible. The metallic materials may be in the form of a wire, cable, chain or have some other appropriate configuration. Other suitable materials include non-metallic, polymeric materials, such as polyaryletherketone, polymethylmethacrylate, polycarbonate, polyurethane, silicone, polyolefins, including polytetrafluoroethylene, and combinations thereof; non-metallic, fiber or fabric materials, including cellulose, polyester, polyvinyl alcohol, polyacrylonitrile, polyamide, polytetrafluoroethylene, polyparaphenylene terephthalamide, polyolefins such as polyethylene, or from combinations of these materials. The polymeric materials may be braided, in the form of a cord, cable, or may have some other appropriate configuration, and combinations thereof. The elongated anchoring bodies described herein, as well as other portions of the anchoring component, may also be formed from a combination of flexible and rigid components. For example,bracket - The securing members may be either integral with the anchoring rod or may be otherwise attached thereto. Referring again to FIGS. 1 and 2, securing
members rod 20 and include aninner surface outer surface members rod 20 wherein a spinal implant may be disposed and secured. Thus,inner surfaces members rod 20 in a variety of ways. For example, securingmember 40 may include threads so that securingmember 40 may be screwed onto anend 22 of anchoringrod 20 that is threaded. Moreover, the securing members may be attached with an adhesive, or other non-resorbable, biocompatible securing materials, including cyanoacrylate adhesive and epoxy glue. Furthermore, securing members may be secured by other means, including clamps, pins, knots, by friction fit, mechanical interlocking or combinations thereof. - Securing
members member 70 may be formed from a fabric that has been formed into a knot and secured to the anchoring rod and end 62 may be formed into, and otherwise define, a knot to form securingmember 80. - As briefly mentioned above, the elongated body, or rod, of the anchoring device described herein may include at least one securing member, and may include two, three, four or more securing members disposed thereon or attached thereto. Furthermore, the securing members may be variously-shaped and may be configured to internally secure, externally secure, or both internally and externally secure an implant, including the implants described herein. Anchoring components that may be used to internally secure implants are shown, for example, in FIGS. 7A-7T.
- Referring now to FIGS. 7A-7D, anchoring devices (200, 220, 240, and 260) including elongated bodies, or anchoring rods (201, 221, 241, and 261, respectively) having a second end (203, 223, 243, and 263, respectively) defining at least one securing member (210, 230, 250 and 270, respectively), shaped in the form of one or more hooks are shown. FIG. 7E depicts an
anchoring device 280 having a securingmember 290 that includes at least one, preferably two or more, such as four, rod extending radially from second end 293 of anchoringrod 291. A multiplicity of such a set of four projecting rods, such as securingmembers 290′ and 295′, may be present, and may be spaced apart along the length ofelongated member 291′ of anchoringdevice 280′ as seen in FIG. 7F. In alternative forms of the invention as seen in FIG. 7G, anchoringdevice 300 includes a single rod defining securingmember 310 that has a longitudinal axis aligned transverse, in this case perpendicular, to the longitudinal axis of anchoringrod 301, although two or more of these extendingrods elongated body 301 from each other, may be present as seen in FIGS. 7H and 7I (anchoringcomponents - In other embodiments of the invention,
second end elongated body component body 324 or a rectangular-shapedbody 324′ as seen in FIGS. 7J and 7L, respectively. A single spherical-shaped securing member may be present, or more than one member may be present wherein each securing member is preferably spaced apart along the length of the elongated body as seen, for example, in FIGS. 7K and 7M (anchoringdevices 340 and 360). These configurations of the securing members may provide mechanical locking for increased fixation. Other anchoring components having securing members that may provide for mechanical locking include anchoringcomponents member 430 is also encompassed as seen with anchoringcomponent 440 in FIG. 7S. Moreover, securingmember 470 may be defined by a taperedsecond end 463 of anchoringrod 461 of anchoringdevice 460 as seen in FIG. 7P. - An anchoring device, such as
anchoring device 480, may include securingmembers 490, such as fibers or other flexible elements, extending radially from anchoringrod 481, preferably fromsecond end 483 of the anchoring rod as seen in FIG. 7T. It is realized that the anchoring devices described above having securing members that internally secure an implant may, if the implant is appropriately positioned on the anchoring device, act to externally secure, or both externally and internally secure, the implant. - For example, anchoring
device 300 may externally secure an implant as shown in FIG. 8A. Anchoringdevice 500 may be used to both internally and externally secure an implant as seen in FIG. 8B with appropriate adjustment in the spacing of the securing members and/or the size of the implant. Similarly, one skilled in the art would be aware that repositioning the implant on many of the anchoring devices described herein with internal securing members may provide for both internal and external securement of an implant. - In yet other embodiments shown in FIGS. 8C-8E, anchoring devices with external securing members are shown, but may aid in internally securing an implant due to their construction. Anchoring
device 560 includes an anchoring rod 561 that is bent atend 562 and is attached, or otherwise connected, to securingmember 40, or other similar securing member as described herein. In a further form of the invention shown in FIG. 8D, anchoringdevice 580 includes an elongated anchoring body, or rod, 581 that connects, or otherwise attaches, to a connectingrod 585 preferably at a point equidistant from theends 586 of the rod. Securing members, such as securingmembers 40, may be attached, or otherwise connected, torod 585. Referring now to FIG. 8E, anchoringdevice 600 that includes an anchoringbody 601 having opposing securing members, such as securingmembers Ends 606 ofbar 605 are preferably connected to two other securing members, such as securingmembers 40. FIG. 8F depicts a variation of anchoringdevice 500 wherein securingmembers device 620 are wave-shaped and are therefore configured to extend through the implant they will secure. FIG. 8G depicts ananchoring device 640 that includes a combination of the mechanical locking features 650 similar to those previously described herein as well as anexternal securing element 651. - In other forms of the invention, an anchoring device is provided that helps to reinforce an implant to prevent the implant from undergoing excessive creep under high load. Referring now to FIG. 8H, anchoring
device 660 includes internal securingmember 670 that is rectangular-shaped and is sized to prevent the implant from undergoing excessive creep under high load. It is noted in all of FIGS. 7 and 8 that implant I is shown in outline to denote how the anchoring bodies may be positioned therein and it is realized that I may represent any of the implants described herein. - The devices described herein are advantageously utilized with a spinal implant, thus forming a spinal implant system. Referring now to FIGS. 9-11,
spinal implant system 90 includes aspinal implant 100 and a spinalimplant anchoring device 10 as described in reference to FIGS. 1 and 2.Inner surface members outer surface 105 ofimplant 100. As seen in FIG. 11, anchoringrod 20 extends through aperture, or other defect, 104 inannulus fibrosis 115 so that thefirst end 21 of anchoringdevice 10 may be anchored toupper vertebra 107 with abone screw 108. First end 21 may, of course, be anchored tolower vertebra 109, or may be secured to bothvertebrae first end 21 is appropriately configured as discussed above. The longitudinal axis X of the rod may extend parallel to the longitudinal axis Y of the implant, but may extend through the implant in a wide variety of directions, as long as the rod functions to anchor the implant in the disc space. Furthermore, the anchoring rod preferably extends at least partially through the implant, but may extend completely through the implant, entering one location, such as an end, and exiting another location, such as another end, including an opposing end. In preferred forms of the invention,implant 100 may include a peripheral supportingband 101 as further described below to provide further lateral support for the implant, as well as to improve the strength of the implant. In one form of the invention,band 101 may have apertures, or other openings therethrough, on opposing sides of the band which are in contact with the securing member to allow the anchoring rod of the anchoring component, or device, to be placed therethrough. Moreover,implant 100 further includes achannel 103 extending therethrough through which the anchoring rod may be disposed. The implant is preferably molded such that the channel is formed during the molding process. However, the channel may be formed after formation of the implant in a variety of ways, including drilling to form a channel having a desired shape with an appropriate drill bit. - Referring now to FIGS. 12-14 in another form of the invention, a
spinal implant system 120 is shown which includesspinal implant 100 and spinalimplant anchoring device 50. Anchoringrod 60 extends through aperture, or defect, 104 ofannulus fibrosis 115. Furthermore,first end 61 of anchoringrod 60 of the anchoring device is secured toupper vertebra 107, but may be secured tolower vertebra 109, or both upper and lower vertebrae, with aninterference screw 110 as more fully described below and as shown in FIG. 14. As seen in FIG. 14, one end of the anchoring rod is wedged between the screw and the bone. Furthermore,first end 61 of anchoringdevice 50 may be secured to bothvertebra first end 61 is appropriately configured as discussed above. - The interference screws described herein can be non-resorbable, resorbable and made form a wide variety of materials, including metals, ceramics, polymers and combinations thereof. Non-resorbable metallic materials include stainless steels, cobalt chrome alloys, titanium, titanium alloys, shape memory materials as described above, especially those exhibiting superelastic behavior and including metals, and alloys thereof. Resorbable materials include polylactide, polyglycolide, tyrosine-derived polycarbonate, polyanhydride, polyorthoester, polyphosphazene, bioactive glass, calcium phosphate, such as hydroxyapatite, and combinations thereof. The anchoring devices may also be anchored with other soft tissue anchors known in the art, including suture anchors commonly used in arthroscopy or sports medicine surgeries, for example. In the case of a soft tissue or suture anchor, the end of the elongated body of the anchoring device is attached to the end of the anchor, which is embedded and anchored in an adjacent vertebral body.
- A wide variety of spinal implants for serving differing functions may be anchored with the anchoring devices described herein, including implants sized and configured for nucleus pulposus replacements, sized and configured for partial or full disc replacements or other disc reconstruction or augmentation purposes. Elastic, or otherwise resilient, implants are most preferred. For example, implants may be formed from hydrophilic materials, such as hydrogels, or may be formed from biocompatible elastomeric materials known in the art, including silicone, polyurethane, polyolefins such as polyisobutylene and polyisoprene, copolymers of silicone and polyurethane, neoprene, nitrile, vulcanized rubber and combinations thereof. In a preferred embodiment, the vulcanized rubber is produced by a vulcanization process utilizing a copolymer produced, for example, as in U.S. Pat. No. 5,245,098 to Summers et al., from 1-hexene and 5-methyl-1,4-hexadiene. Preferred hydrophilic materials are hydrogels. Suitable hydrogels include natural hydrogels, and those formed from polyvinyl alcohol, acrylamides such as polyacrylic acid and poly (acrylonitrile-acrylic acid), polyurethanes, polyethylene glycol, poly(N-vinyl-2-pyrrolidone), acrylates such as poly(2-hydroxy ethyl methacrylate) and copolymers of acrylates with N-vinyl pyrolidone, N-vinyl lactams, acrylamide, polyurethanes and polyacrylonitrile or may be formed from other similar materials that form a hydrogel. The hydrogel materials may further be cross-linked to provide further strength to the implant. Examples of polyurethanes include thermoplastic polyurethanes, aliphatic polyurethanes, segmented polyurethanes, hydrophilic polyurethanes, polyetherurethane, polycarbonate-urethane and silicone polyether-urethane. Other suitable hydrophilic polymers include naturally-occurring materials such as glucomannan gel, hyaluronic acid, polysaccharides, such as cross-linked carboxyl-containing polysaccharides, and combinations thereof. The nature of the materials employed to form the elastic body should be selected so the formed implants have sufficient load bearing capacity. In preferred embodiments, a compressive strength of at least about 0.1 MPa is desired, although compressive strengths in the range of about 1 MPa to about 20 MPa are more preferred.
- The implants can be shaped as desired. For example, the nucleus pulposus implants may take the form of a cylinder, a rectangle, or other polygonal shape or may be substantially oval. The implants may include
elastic bodies 750 that are tapered, such as at one end, as seen in FIGS. 15A and 15B, in order to create or maintain lordosis. Furthermore, in certain forms of the invention, the implants generally conform to the shape of the nuclear disc space. Additionally, implants can be sized to fit within an intervertebral disc space, preferably surrounded by an annulus fibrosis, or at least partially surrounded by an annulus fibrosis. That is, the implants preferably are of a height and have a diameter that approximates the height and diameter of an intervertebral disc space. In certain forms of the invention, a spinal implant may be a nucleus pulposus implant and may thus be sized to fit within the natural intervertebral disc space. In other embodiments, the spinal implants may be disc replacements as described herein, and may be sized to fit within the intervertebral disc space that includes the space resulting when the inner annulus fibrosis layer, or a portion thereof, is removed. Such a spinal implant would therefore be sized to fit within the larger intervertebral disc space that includes the space resulting from removal of a portion of the annulus fibrosis, and would thus typically have a width or diameter that is substantially larger than the natural nucleus pulposus. - As mentioned above, the implant to be anchored preferably is reinforced for increased strength and to decrease lateral deformation of the implant. Accordingly, in yet another aspect of the invention, a reinforced spinal implant is provided. Referring now to FIGS. 16 and 17,
implant 120 includes a load bearingelastic body 121 with anupper surface 122 and alower surface 123.Implant 120 includes a preferably flexible, supporting member, such as peripheral supportingband 130 disposed circumferentially aboutbody 121.Band 130 is similar toband 100 discussed above, with the exception that band 130 does not have openings therethrough on opposing sides of the band. As the implant, including the elastic body and supporting band, advantageously may replace all or a portion of the natural nucleus pulposus, while retaining the annulus fibrosis or a portion thereof, the implant may be sized to fit within the intervertebral disc space defined by the annulus fibrosis or a portion thereof. - As seen in FIG. 16,
elastic body 121 includes upper andlower surfaces elastic body 121 to articulate against the endplates to minimize abrasive wear of supportingband 130 and the endplates. Although the amount of the upper and lower surfaces ofelastic body 121 that are exposed may vary, typically at least about 50%, preferably at least about 70%, more preferably at least about 80% and most preferably at least about 90% of the surfaces are exposed. In certain forms of the invention, the elastic body core may function as a nucleus pulposus, and thus functions as a load bearing component with stress transfer capabilities. - Peripheral supporting
band 130 helps restrict excessive horizontal deformation ofelastic body 121 upon loading conditions, as seen progressively in FIG. 18A, thereby helping to restore and maintain disc height. The hoop stress in the band increases exponentially after some small, initial deformation as seen in FIG. 18B. Band 130 preferably decreases lateral deformation, compared to deformation of an implant without the circumferential reinforcing band, as desired. Band 130 may, for example, decrease lateral deformation by at least about 20%, preferably at least about 40%, further preferably at least about 60%, more preferably at least about 80% and most preferably at least about 90%. An implant, such as one that includes an elastic body, having such a flexible supporting band, will be flexible and otherwise resilient to allow the natural movements of the disc and provides shock absorption capability at low to moderate applied stress, but will resist excessive deformation for disc height maintenance under high loading conditions. As described herein in the case of a lumbar disc, for example, low applied stress includes a force of about 100 Newtons to about 250 Newtons, moderate stress includes a force of about 250 Newtons to about 700 Newtons, and high loading conditions, or high stress, includes a force of about above 700 Newtons. Such a reinforced implant may be advantageously anchored with the anchoring devices described herein. Moreover, other outer covers, or jackets, as described in U.S. Pat. No. 5,674,295 may be utilized to reinforce implants to be anchored with the devices described herein. In preferred forms of the invention, the bands, jackets, or other outer covers or similar supporting members are flexible in that they may be folded or otherwise deformed, but are substantially inelastic so that the implant is more fully reinforced or otherwise supported. - Peripheral supporting
band 130, as well as other outer covers, or jackets, may be made from a wide variety of biocompatible polymers, metallic materials, or combination of materials that form a strong but flexible support to prevent excessive lateral (horizontal) deformation of the core under increasing compressive loading. Suitable materials include non-woven, woven, braided, or fabric materials made from polymeric fibers including cellulose, polyethylene, polyester, polyvinyl alcohol, polyacrylonitrile, polyamide, polytetrafluoroethylene, polyparaphenylene terephthalamide, and combinations thereof. Other suitable materials include non-reinforced or fiber-reinforced elastomers such as silicone, polyolefins such as polyisobutylene and polyisoprene, polyurethane, copolymers of silicone and polyurethane, neoprene, nitrile, vulcanized rubber and combinations thereof. In a preferred form of the invention, a combination, or blend, of silicone and polyurethane is used. Furthermore, the vulcanized rubber is preferably produced as described above for the spinal implants. Supportingband 130 is advantageously made from materials described herein that allow it to be porous, which, in the case of an elastic body made from a hydrogel, or other hydrophilic material, allows fluid circulation through the elastic core body to enhance pumping actions of the intervertebral disc. Supporting members may further be formed from carbon fiber ceramic, ceramic fibers, metallic fibers, or other similar fibers described, for example, in U.S. Pat. No. 5,674,295, or from metallic materials that include shape memory materials as described above, especially those exhibiting superelastic behavior, titanium, titanium alloys, stainless steel, cobalt chrome alloys and combinations thereof. FIGS. 19A-19D show supporting bands of various patterns, including braided patterns (bands - In addition to reinforcing the implants described herein with an outer cover, jacket or supporting band as described above,
spinal implants 100, such as those formed from a hydrogel material, that are advantageously anchored with the anchoring devices described herein may be reinforced by forming the implant by molding hydrogels of different stiffness together and by annealing methods that include dipping the hydrogel in a hot oil bath, as described in U.S. Pat. No. 5,534,028. Other suitable reinforced spinal implants, such as nucleus pulposus implants, that may advantageously be used in the system of the present invention include those described in U.S. Pat. No. 5,336,551, as well as the novel implants described herein. As discussed above, the implant may be advantageously shaped to conform to the intervertebral disc space, or shaped as otherwise desired, as long as the implant has load bearing capability. Although the amount of load the implant is required to bear may vary depending on several factors, including the particular location in which the implant will be positioned, as well as the general health of the surrounding intervertebral discs, it is preferred that the implant be able to bear a load of at least about 20 Newtons for cervical discs, at least about 50 Newtons for thoracic discs and at least about 100 Newtons for lumbar discs. - In yet other forms of the invention, an implant reinforced with a peripheral supporting band as described above is provided that is further reinforced with one or more straps. The straps may be advantageous in preventing the peripheral supporting band described herein from slipping, or otherwise sliding off the implant. Referring now to FIGS. 20 and 21, at least one
strap 134 extends alongupper surface 122 and at least onestrap 135 extends alonglower surface 123 ofelastic body 121 ofimplant 140.Ends 136 ofstrap 134 and ends 137 ofstrap 135 are each preferably connected, or otherwise attached, to peripheral supportingband 130′. The point of attachment may be any location that will secure the strap, including at theupper margins 138 of the band,lower margins 139 of the band or any region between the upper and lower margins. Although twostraps upper surface 122 andlower surface 123, respectively, in FIGS. 20 and 21, one continuous strap may be utilized that extends completely around the implant, or the strap utilized may be in multiple pieces, as long as the combination of straps are sufficient to prevent excessive slipping and or sliding of the supporting band. Furthermore, more than one strap may extend alongupper surface 122 and more than one strap may extend alonglower surface 123. For example, as seen in FIGS. 22 and 23, straps 820, 830, 840 and 850 ofimplant 150 are attached to strap 130″.Straps - As mentioned above, the spinal implant with the flexible peripheral supporting band may be anchored utilizing the anchoring devices described herein. In other forms of the invention, implants as described herein may be anchored with an outer, preferably resorbable, shell as described in U.S. patent application Ser. No. 09/650,525 to Trieu, filed Aug. 30, 2000. In further forms of the invention, the implant may further include various outer surface features that may further restrain movement of the implant in the intervertebral disc space, with or without the outer shell. Such surface features are also more fully described in U.S. patent application Ser. No. 09/650,525 to Trieu, filed Aug. 30, 2000.
- In yet other forms of the invention, a
tension band 700 may be secured to the anchoring device and to an adjacent vertebra to, for example, provide further stabilization of the device, especially wherein the annulus and/or the ligament surrounding the annulus at the defect site are compromised. Referring now to FIGS. 24 and 25, oneend 701 ofband 700 may be attached to an anchoring device, such as anchoringdevice 10″ (similar to anchoringdevice 10 except thatbracket 123″ is utilized), at, for example,bracket 123″, and theother end 702 may be secured to aplate 710, such as a metal plate, that is secured to the adjacentvertebra utilizing screws 108 as described herein. Band 700 may be attached to the anchoring device in a variety of ways, including crimping, tying, mechanical locking or may be secured with the same screws used to secure the anchoring device to the vertebral bodies. If two anchoring devices are utilized as described below, or if a single anchoring device is used that is secured to both adjacent vertebrae, oneend 701 oftension band 700 may be attached to one of the brackets, or other areas, of the first anchoring device and theother end 702 ofband 700 may be attached to the other bracket, or other area, of the second anchoring device. The tension band is preferably flexible to allow some degree of motion, but is substantially inelastic to prevent excessive extension. - The tension band may be formed from a wide variety of natural or synthetic tissue biocompatible materials. Natural materials include autograft, allograft and xenograft tissues. Synthetic materials include metallic materials and polymers. The metallic materials can be formed from shape memory alloy, including shape memory materials made from, for example, the nickel-titanium alloy known as Nitinol as described above. The shape memory materials may exhibit shape memory as described above, but preferably exhibit superelastic behavior. Other metallic materials include titanium alloy, titanium, stainless steel, and cobalt chrome alloy. Suitable polymeric materials include, for example, polyethylene, polyester, polyvinyl alcohol, polyacrylonitrile, polyamide, polytetrafluoroethylene, poly-paraphenylene, terephthalamide and combinations thereof. The materials used to form the tension band can be in a variety of forms, including the form of a fiber, woven, or non-woven fabric, braided, bulk solid and combinations thereof. The tension band may further be treated, such as by coating and/or impregnating, with bioactive materials that may enhance tissue ingrowth and/or attachment, including hydroxyapatite, bioglass, and growth factors. Suitable growth factors include transforming growth factors, insulin-like growth factors, platelet-derived growth factors, fibroblast growth factors, bone morphogenetic proteins as further described herein and combinations thereof.
- In yet another aspect of the invention, methods of anchoring a spinal implant are provided. In one form of the invention, a method includes providing an elastic spinal implant and an anchoring component as described herein. The elongated body, or anchoring rod, component of the anchoring component is at least partially extended, or otherwise disposed, through the implant. The implant may include a pre-formed channel therethrough, preferably formed during formation of the implant, through which the anchoring rod may be extended. In alternative embodiments, the implant may be formed around internal securing members as discussed above. The longitudinal axis of the anchoring rod may also extend parallel to the longitudinal axis of the implant, or any other direction as mentioned above that will allow the anchoring rod to anchor, secure, restrain or otherwise hold the implant in the disc space. As an example, the anchoring rod, as well as the securing members, may take a tortuous path through the implant, especially when the anchoring bodies have ends defining variously-shaped securing members, as more fully described above, with reference to, for example, FIGS. 7N, &7O and 7T.
- As further discussed above, in those forms of the invention wherein a securing member is at an end of the implant, the securing member may be attached after the elongated body component is extended through the implant. For example, with reference to FIGS. 1 and 7, securing
member 40 may be attached to end 22 ofelongated body 20 after anchoringrod 20 is extended throughchannel 103 ofimplant 100. Moreover, the securing member may also be formed afterrod 20 is extended throughchannel 103, as in the case where securingmember 40 is defined by a knot structure. In other forms of the invention, the channel may be formed after the implant is formed by forming a channel with an appropriate tool, such as a drill with an appropriately sized and shaped drill bit. One of the ends of the anchoring component are then secured to an adjacent vertebra. - In further aspects of the invention, methods of reducing deformation of a spinal implant are provided. In one embodiment, a method includes disposing a flexible peripheral supporting band as described above circumferentially about the implant.
- The implants formed from a hydrogel, or other similar hydrophilic material described herein, including the supporting band of the reinforced implants, may advantageously deliver desired pharmacological agents. The pharmacological agent may include a growth factor that may advantageously repair a damaged annulus fibrosis, endplates or may have some other beneficial effect. A wide variety of growth factors may advantageously be employed in the present invention. For example, the growth factor may include a bone morphogenetic protein, transforming growth factors, such as transforming growth factor-β (TGF-β), insulin-like growth factors, platelet-derived growth factors, fibroblast growth factors, or other similar growth factor having the ability to repair the endplates, annulus fibrosis and/or nucleus pulposus of an intervertebral disc, or the ability to have some other beneficial effect. The growth factors, or other pharmacological agents, are typically included in the implant in therapeutically effective amounts. For example, the growth factors may be included in the implants in amounts effective in repairing an intervertebral disc, including repairing the endplates, annulus fibrosis and nucleus pulposus. Although these amounts will depend on the specific case, the implants may typically include no more than about five weight percent of the growth factors, and preferably no more than about one weight percent of the growth factors. In a preferred form of the invention, the growth factor is a bone morphogenetic protein. Recombinant human bone morphogenetic proteins (rhBMPs) are further preferred because they are available in large quantities and do not transmit infectious diseases. Most preferably, the bone morphogenetic protein is a rhBMP-2, rhBMP-4 or heterodimers thereof. However, any bone morphogenetic protein is contemplated, including bone morphogenetic proteins designated as BMP-1 through BMP-18.
- BMPs are available from Genetics Institute, Inc., Cambridge, Mass. and may also be prepared by one skilled in the art as described in U.S. Pat. No. 5,187,076 to Wozney et al.; U.S. Pat. No. 5,366,875 to Wozney et al.; U.S. Pat. No. 4,877,864 to Wang et al.; U.S. Pat. No. 5,108,922 to Wang et al.; U.S. Pat. No. 5,116,738 to Wang et al.; U.S. Pat. No. 5,013,649 to Wang et al.; U.S. Pat. No. 5,106,748 to Wozney et al.; and PCT Patent Nos. WO93/00432 to Wozney et al.; WO94/26893 to Celeste et al.; and WO94/26892 to Celeste et al. All bone morphogenic proteins are contemplated whether obtained as above or isolated from bone. Methods for isolating bone morphogenetic protein from bone are described, for example, in U.S. Pat. No. 4,294,753 to Urist and Urist et al., 81 PNAS 371, 1984.
- In other forms of the invention, the pharmacological agent may be one that is used for treating various spinal conditions, including infected spinal cords, cancerous spinal cords and osteoporosis. Such agents include antibiotics, analgesics and anti-inflammatory drugs, including steroids. Other such agents are well know to the skilled artisan. These agents are also used in therapeutically effective amounts that will treat the various conditions and the symptoms they cause. Such amounts may be determined by the skilled artisan depending on the specific case.
- The pharmacological agents are preferably dispersed within the hydrogel, or other hydrophilic, implant for in vivo release, and/or, with respect to implants with an elastomeric resorbable outer shell or those with a flexible supporting band, may be dispersed in either the band, the outer shell, or both. The hydrogel can be cross-linked chemically, physically, or by a combination thereof, in order to achieve the appropriate level of porosity to release the pharmacological agents at a desired rate. The agents may be released upon cyclic loading, and, in the case of implants including a resorbable outer shell, upon resorption of the shell. The pharmacological agents may be dispersed in the implants by adding the agents to the solution used to form the implant, as long as the processing conditions will not adversely affect the agent. Alternatively, the implants may be soaked in an appropriate solution containing the agent, or by other appropriate methods known to the skilled artisan.
- While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it being understood that only the preferred embodiment has been shown and described and that all changes and modifications that come within the spirit of the invention are desired to be protected. For example, in addition to being straight, the elongated bodies of the anchoring device may exhibit other advantageous shapes as shown in FIGS. 26 and 27. As seen in FIG. 26, anchoring
rod 920′ is arcuate. As seen in FIG. 27, anchoringrod 920″ has a bend adjacent to securingmember 40. Other bent or angled anchoring components may be understood by those of ordinary skill in the art, and such embodiments are encompassed by this invention. Furthermore, the devices described herein may be inserted and anchored via a wide variety of approaches, including posterior, lateral, oblique and anterior as shown in FIGS. 28-31, respectively. Moreover, the nucleus pulposus implant systems may include one or more implants disposed on the anchoring rods of the anchoring devices described herein. As seen in FIG. 32, twoimplants 100′ are disposed on anchoringrod 20 of anchoringdevice 10. Thus, typically at least one implant is included in the implant systems described herein. - Additionally, in other forms of the invention, the spinal implant systems may include one or more elastic bodies and one or more anchoring devices. Referring now to FIG. 33, two anchoring devices are included in the system along with two elastic bodies, each elastic body disposed on a
different anchoring device rods elongated bodies devices - All references cited herein are indicative of the level of skill in the art and are hereby incorporated by reference in their entirety.
Claims (14)
1. A device for anchoring a spinal implant in an intervertebral disc space, comprising:
(a) an anchoring rod having a first end and a second end, said rod configured to anchor said implant;
(b) at least one securing member attached to said rod, said device securable to an adjacent vertebra.
2. The device of claim 1 , wherein said first end of said anchoring rod is securable to said adjacent vertebra.
3. The device of claim 1 , wherein two opposing securing members are attached to said anchoring rod, said members spaced apart along the length of said rod and defining a region for disposing said implant therebetween, said device securable to an adjacent vertebra.
4. The device of claim 1 , wherein said securing member is formed of material selected from shape memory material, titanium alloy, titanium, stainless steel, cobalt chrome alloy, carbon fiber reinforced composite, polyolefins, polyaryletherketone, polymethylmethacrylate, polycarbonate, polyurethane, silicone and combinations thereof.
5. The device of claim 4 , wherein said shape memory material is a shape memory alloy that exhibits superelastic behavior.
6. The device of claim 1 , wherein said device is comprised of a metallic material, a non-metallic material, or a combination thereof.
7. The device of claim 6 , wherein said metallic material is selected from a shape memory material, titanium alloy, titanium, stainless steel, cobalt chrome alloy, and combinations thereof.
8. The device of claim 8 , wherein said non-metallic material is selected from polyethylene, polyparaphenylene terephthalamide, cellulose, carbon fiber reinforced composite, polyester, polyvinyl alcohol and combinations thereof.
9. The device of claim 1 , wherein said first end of said anchoring rod is securable to an adjacent vertebra with a bone screw or a soft tissue anchor.
10. The device of claim 9 , wherein said bone screw is an interference screw and said soft tissue anchor is a suture anchor.
11. The device of claim 1 , wherein said anchoring rod is securable to an adjacent vertebra.
12. The device of claim 1 , wherein said first end of said anchoring rod is securable to an adjacent vertebra.
13. The device of claim 1 , wherein said device further includes a bracket, said first end of said rod securable to said bracket.
14.-62. (cancelled)
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Also Published As
Publication number | Publication date |
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JP4194634B2 (en) | 2008-12-10 |
AU2002213257B2 (en) | 2005-06-16 |
WO2002034169A2 (en) | 2002-05-02 |
EP1328218A2 (en) | 2003-07-23 |
WO2002034169A3 (en) | 2002-07-11 |
US6733531B1 (en) | 2004-05-11 |
JP2007222655A (en) | 2007-09-06 |
CA2425973A1 (en) | 2002-05-02 |
JP2004512095A (en) | 2004-04-22 |
AU1325702A (en) | 2002-05-06 |
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