US20040235903A1 - Amorphous form of esomeprazole salts - Google Patents
Amorphous form of esomeprazole salts Download PDFInfo
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- US20040235903A1 US20040235903A1 US10/690,897 US69089703A US2004235903A1 US 20040235903 A1 US20040235903 A1 US 20040235903A1 US 69089703 A US69089703 A US 69089703A US 2004235903 A1 US2004235903 A1 US 2004235903A1
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- United States
- Prior art keywords
- esomeprazole
- salt
- amorphous form
- cation
- solution
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- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical class C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 claims abstract description 41
- 229960004770 esomeprazole Drugs 0.000 claims abstract description 37
- 150000003839 salts Chemical class 0.000 claims abstract description 33
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 27
- 239000002904 solvent Substances 0.000 claims description 24
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 18
- 150000001768 cations Chemical class 0.000 claims description 18
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000001694 spray drying Methods 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 7
- 229910052791 calcium Inorganic materials 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
- 229910052744 lithium Inorganic materials 0.000 claims description 7
- 229910052749 magnesium Inorganic materials 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 229910052700 potassium Inorganic materials 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 6
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 6
- 238000002441 X-ray diffraction Methods 0.000 claims description 6
- 229910021529 ammonia Inorganic materials 0.000 claims description 6
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 6
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 6
- 150000002576 ketones Chemical class 0.000 claims description 6
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 6
- 125000001475 halogen functional group Chemical group 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 3
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 3
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 238000001704 evaporation Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 150000003138 primary alcohols Chemical class 0.000 claims description 3
- 150000003333 secondary alcohols Chemical class 0.000 claims description 3
- 150000003509 tertiary alcohols Chemical class 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract description 13
- 229960000381 omeprazole Drugs 0.000 abstract description 13
- -1 i.e. Chemical compound 0.000 abstract description 6
- KWORUUGOSLYAGD-YPPDDXJESA-N esomeprazole magnesium Chemical compound [Mg+2].C([S@](=O)C=1[N-]C2=CC=C(C=C2N=1)OC)C1=NC=C(C)C(OC)=C1C.C([S@](=O)C=1[N-]C2=CC=C(C=C2N=1)OC)C1=NC=C(C)C(OC)=C1C KWORUUGOSLYAGD-YPPDDXJESA-N 0.000 description 22
- 239000000243 solution Substances 0.000 description 20
- 229960000197 esomeprazole magnesium Drugs 0.000 description 18
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 239000000047 product Substances 0.000 description 7
- 239000007921 spray Substances 0.000 description 7
- 238000002329 infrared spectrum Methods 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 150000004683 dihydrates Chemical group 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- MQEUGMWHWPYFDD-JIDHJSLPSA-N magnesium;6-methoxy-2-[(s)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical compound [Mg].C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C MQEUGMWHWPYFDD-JIDHJSLPSA-N 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000004211 gastric acid Anatomy 0.000 description 3
- 230000027119 gastric acid secretion Effects 0.000 description 3
- 238000000634 powder X-ray diffraction Methods 0.000 description 3
- 150000004684 trihydrates Chemical class 0.000 description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 150000004292 cyclic ethers Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 159000000011 group IA salts Chemical class 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 159000000003 magnesium salts Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 150000002825 nitriles Chemical class 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- SUBDBMMJDZJVOS-XMMPIXPASA-N (R)-omeprazole Chemical compound C([S@@](=O)C=1NC2=CC=C(C=C2N=1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-XMMPIXPASA-N 0.000 description 1
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- APQIUTYORBAGEZ-UHFFFAOYSA-N 1,1-dibromoethane Chemical compound CC(Br)Br APQIUTYORBAGEZ-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 150000001556 benzimidazoles Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to an amorphous form of the salts of the (−) enantiomer or (S)-enantiomer of omeprazole, i.e., esomeprazole. The invention also relates to processes for preparing amorphous esomeprazole salts and pharmaceutical compositions that include the amorphous esomeprazole salts.
Description
- The field of the invention relates to an amorphous form of the salts of the (−) enantiomer or (S)-enantiomer of omeprazole, i.e., esomeprazole. The invention also relates to processes for preparing amorphous esomeprazole salts and pharmaceutical compositions that include the amorphous esomeprazole salts.
- Chemically, omeprazole is 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole. Omeprazole and therapeutically acceptable salts thereof are described in U.S. Pat. No. 4,255,431. Certain specific alkaline salts of omeprazole are disclosed in U.S. Pat. No. 4,738,974. Omeprazole is transformed into an effective inhibitor of gastric acid secretion in mammals, and is therefore useful as an anti-ulcer agent. Omeprazole may be used to prevent and/or treat gastric acid related disorders and gastrointestinal inflammatory diseases in mammals. In man, for example, omeprazole may be used to prevent and/or treat gastritis, gastric ulcer and duodenal ulcer.
- Omeprazole is a racemic mixture of its two single enantiomers, the (R)- and (S)-enantiomer of omeprazole. These enantiomers are commonly referred to as (R)-omeprazole and (S)-omeprazole, respectively. The enantiomer, (S)-omeprazole, is commonly referred to as esomeprazole.
- WO 94/27988 discloses certain salts of the single enantiomers of omeprazole and their preparation. These compounds are described as having improved pharmacokinetic properties which give an improved therapeutic profile, such as a lower degree of variation between individuals taking the compound.
- WO 96/02535 discloses a process for preparing the single enantiomers of omeprazole and salts thereof. WO 98/54171 discloses a process for the preparation of the trihydrate of the magnesium salt of (ES)-omeprazole.
- Esomeprazole, like many other similar benzimidazole compounds, is not stable in its free form and is susceptible to degradation in acid and neutral media. It has been found that alkali metal or alkaline earth metal salts of esomeprazole are more stable during storage than the corresponding neutral form.
- U.S. Pat. No. 5,714,505 describes alkaline salts of the (−) enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridiniyl)methyl]sulfinyl]-1H-benzimidazoles (i.e., esomeprazole) including the magnesium salt, which are used for inhibiting gastric acid secretion. Esomeprazole magnesium is prepared according to Examples 5, 6, and 7 of the '505 patent in optically pure crystalline form by precipitation/crystallization.
- U.S. Pat. No. 6,124,464 discloses another process for preparing crystalline esomeprazole magnesium. U.S. Pat. No. 6,369,085 discloses three different types of crystalline esomeprazole magnesium viz. dihydrate form A, dihydrate form B and the trihydrate form. However, the inventors are not aware of any disclosure of an amorphous form of esomeprazole salts, including amorphous esomeprazole magnesium, in the prior art. It is known that different morphs of biologically active compounds may have different absorption profile in vivo and consequently different pharmacokinetic profile.
- In one general aspect there is provided an amorphous form of a salt of esomeprazole.
- Embodiments of the amorphous form of the salt of esomeprazole may include one or more of the following features. For example, the cation may be selected from the group that includes Na, Mg, Li, K, Ca, and N(R)4, where R is hydrogen or an alkyl with 1-4 carbon atoms.
- The amorphous form of the salt of esomeprazole may have the X-ray diffraction pattern of FIG. 1 and the IR spectra of FIG. 2.
- In another general aspect there is provided a pharmaceutical composition that includes a therapeutically effective amount of an amorphous form of a salt of esomeprazole; and one or more pharmaceutically acceptable carriers, excipients or diluents.
- Embodiments of the pharmaceutical composition may include one or more of the following features. For example, the cation may be selected from the group that includes Na, Mg, Li, K, Ca, and N(R)4, where R is hydrogen or an alkyl with 1-4 carbon atoms.
- The amorphous form of the salt of esomeprazole may have the X-ray diffraction pattern of FIG. 1 and the IR spectra of FIG. 2.
- In another general aspect there is provided a process for the preparation of a salt of the amorphous form of esomeprazole. The process includes preparing a solution of a salt of esomeprazole in one or more solvents; and recovering the salt of esomeprazole in the amorphous form from the solution thereof by the removal of the solvent.
- Embodiments of the process may include one or more of the following features. For example, the cation may be selected from the group that includes Na, Mg, Li, K, Ca, and N(R)4, where R is hydrogen or an alkyl with 1-4 carbon atoms.
- The solvent may be one or more of lower alkanol, ketone, ester, chlorinated solvent, acetonitrile or mixtures thereof. The lower alkanol may include one or more of primary, secondary and tertiary alcohol having from one to six carbon atoms. The lower alkanol may include one or more of methanol, ethanol, denatured spirit, n-propanol, isopropanol, n-butanol, isobutanol, and t-butanol. In particular, the lower alkanol may include one or more of methanol, ethanol, and denatured spirit.
- The ketone may include one or more of acetone, 2-butanone, and 4-methylpentan-2-one. The ester may include one or more of ethyl acetate and n-butyl acetate. The chlorinated solvent may include one or more of chloroform and dichloromethane. Removing the solvent may include one or more of distillation, distillation under vacuum, evaporation, spray drying, and freeze drying.
- The salt of esomeprazole in an amorphous form may be recovered from the solution by spray drying. Alternatively, the salt of esomeprazole in an amorphous form may be recovered from the solution by freeze-drying. The process may include further forming of the product so obtained into a finished dosage form.
- The process may include further drying of the product obtained from the solution.
- The process may further include adding one or both of an organic amine and ammonia to the solution. The organic amine and/or ammonia may be added to the solution prior to removal of the solvent.
- The process may produce the amorphous form of the salt of esomeprazole having the X-ray diffraction pattern of FIG. 1 and the IR spectra of FIG. 2.
- The details of one or more embodiments of the inventions are set forth in the description below. Other features, objects and advantages of the inventions will be apparent from the description and claims.
- FIG. 1 is an x-ray powder diffraction pattern of amorphous esomeprazole.
- FIG. 2 is an infra-red spectra in KBr of amorphous esomeprazole magnesium prepared as described herein.
- The mentors have found a new form of esomeprazole salts, the amorphous form and, in particular, the amorphous esomeprazole magnesium salt. The new form is characterized by its X-ray powder diffraction pattern and IR spectra as shown in FIGS. 1 and 2, respectively. The inventors also have developed a process for the preparation of the amorphous form of esomeprazole salts, including the esomeprazole magnesium salt, by recovering the amorphous esomeprazole salt from a solution thereof in a suitable solvent by spray drying. The resulting amorphous form of salts of esomeprazole include, for example, Na, Mg, Li, K, Ca, and N(R)4, where R is hydrogen or an alkyl group with 1-4 carbon atoms. The inventors also have developed pharmaceutical compositions that contain the amorphous form of the esomeprazole salts, including the esomeprazole magnesium salt, in admixture with one or more solid or liquid pharmaceutical diluents, carriers, and/or excipients. These pharmaceutical compositions may be used for the treatment of gastric acid-related diseases by inhibition of gastric acid secretion.
- In general, the solution of esomeprazole salt may be obtained by dissolving a crystalline esomeprazole salt in a suitable solvent. Alternatively, such a solution may be obtained directly from a reaction in which esomeprazole salt is formed. The solvent may be removed from the solution by a technique which includes, for example, distillation, distillation under vacuum, evaporation, spray drying, and freeze drying.
- In one aspect, a salt of esomeprazole in amorphous form is recovered from the solution using a spray drying technique. A Mini-Spray Dryer (Model: Buchi 190, Switzerland) can be used. The Buchi 190 Mini-Spray Dryer operates on the principle of nozzle spraying in a parallel flow, i.e., the sprayed product and the drying gas flow in the same direction. The drying gas can be air or inert gases such as nitrogen, argon and carbon dioxide.
- In another aspect, a salt of esomeprazole in amorphous form can be recovered from the solution using a freeze drying technique. A freeze dryer (Model:Virtis Genesis SQ Freeze Dryer) can be used in this technique. The Virtis Genesis SQ Freeze Dryer operates on the principle of lyophilization, i.e., a process of stabilizing initially wet materials (aqueous solution or suspensions) by freezing them, then subliming the ice while simultaneously desorbing some of the bound moisture (primary drying). Following removal of the ice, desorption may be continued (secondary drying). This process may be carried out under vacuum.
- The term “suitable solvent” includes any solvent or solvent mixture in which esomeprazole salt, including esomeprazole magnesium, is soluble, including, for example, nitriles, cyclic ethers, lower alkanol, ketones, esters, chlorinated solvents, acetonitrile and mixtures thereof. Examples of alcohols include methanol, ethanol, isopropanol, and the like. Examples of halogenated hydrocarbons include dichloromethane, dichloroethane, dibromoethane, and the like. Examples of nitrile include acetonitrile and the like. Examples of cyclic ethers include tetrahydrofuran, dioxane, and the like. Examples of alkanol include those primary, secondary and tertiary alcohols having from one to six carbon atoms. Suitable lower alkanol solvents include methanol, ethanol, denatured spirit, n-propanol, isopropanol, n-butanol, isobutanol and t-butanol. Examples of ketones or esters include solvents such as acetone, 2-butanone, 4-methylpentan-2-one, ethyl acetate and n-butylacetate. A suitable chlorinated solvent includes one or both of dichloromethane and chloroform. Mixtures of all of these solvents are also contemplated.
- An organic amine or ammonia may optionally be added to the solution of esomeprazole salt, including esomeprazole magnesium, before spray drying. The organic amine may be one or more of diethylamine, triethylamine, and the like. One purpose of adding the organic amine or ammonia is to provide stability to the esomprazole during processing.
- If crystalline esomeprazole magnesium is used as a starting material it may be in the form of any of the various polymorphic forms known in the prior art including dihydrate form A, dihydrate form B, trihydrate, etc. Esomeprazole magnesium may be prepared by any of the known methods such as those cited in U.S. Pat. Nos. 5,714,504; 6,124,464; and 6,369,085. A solution of esomeprazole magnesium obtained in situ during the preparation process may be used as such for spray drying.
- The spray drying may be accomplished using a spray dryer which operates on the principle of nozzle spraying in a parallel flow, i.e., the sprayed product and the drying gas flow in the same direction. The drying gas can be air or one or more inert gases such as nitrogen, argon, and carbon dioxide. Moreover, the product obtained may be further or additionally dried to achieve the desired moisture values. For example, the product may be further or additionally dried in a tray drier, dried under vacuum and/or in a Fluid Bed Dryer.
- The resulting amorphous form of esomeprazole salt and, in particular, esomeprazole magnesium, may be formulated into ordinary dosage forms such as, for example, tablets, capsules, pills, solutions, etc. In these cases, the medicaments can be prepared by conventional methods with conventional pharmaceutical excipients. In addition to the common dosage forms set out above, the amorphous form of esomeprazole magnesium may also be administered by controlled release means and/or delivery devices.
- Further, the amorphous esomeprazole salt dosage forms described herein can be used in a method for treatment of gastric acid related diseases. The method of treatment includes administering to a mammal in need of treatment a dosage form that includes a therapeutically effective amount of the amorphous form of esomeprazole salt, including the esomeprazole magnesium salt.
- The present inventions are further illustrated by the following examples which are provided merely to be exemplary of the inventions and are not intended to limit the scope of the invention. Although these examples are directed to amorphous esomeprazole magnesium, the principles described in these examples can be applied to other salts of amorphous esomeprazole.
- Esomeprazole magnesium trihydrate (200 g) was dissolved in a mixture of dichloromethane (1200 ml) and methanol (1200 ml) at 25-30° C. Any undissolved material was filtered off and triethylamine (2 ml) was added to the filtrate. The clear solution thus obtained was spray dried in a mini spray dryer (Model Buchi-190) with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C. in2 to 3 hours. The solid was further dried under vacuum at 60-65° C. for 14 to 15 hours to yield 120 g of esomeprazole magnesium of amorphous form. X-ray powder diffraction pattern showed a plain halo, which demonstrates the amorphous nature of the product (FIG. 1). The following physical characteristics were obtained: Purity 99.77% by HPLC, Chiral purity 99.90% by HPLC, SOR 145.9°, Mg content 3.4.
- Esomeprazole magnesium trihydrate (20 g) was dissolved in methanol (200 ml) at 25-30° C. Any undissolved material was filtered off and triethylamine (0.2 ml) was added to the filtrate. The clear solution thus obtained was subjected to spray drying with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C. The solid was further dried under vacuum at 60-65° C. for 14 to 15 hours to yield 11.5 g of esomeprazole magnesium of amorphous form.
- Esomeprazole magnesium trihydrate (10 g) was dissolved in a mixture of dichloromethane (50 ml) and ethanol (70 ml) at 25-30° C. Any undissolved material was filtered off. The clear solution thus obtained was spray dried with an inlet temperature of 70-80° C. and an outlet temperature of 22-42° C. The solid was further dried under vacuum at 60-65° C. for 14 to 15 hours to yield 5.82 g of esomeprazole magnesium of amorphous form.
- Esomeprazole magnesium trihydrate (100 g) was dissolved in methanol (1000 ml) at 25-30° C. Any undissolved material was filtered off. The clear solution thus obtained was spray dried with an inlet temperature of 65-68° C. and an outlet temperature of 22-42° C. The solid was further dried under vacuum at 60-65° C. for 14 to 15 hours to yield 55 g of esomeprazole magnesium of amorphous form.
- While several particular forms of the inventions have been described, it will be apparent that various modifications and combinations of the inventions detailed in the text can be made without departing from the spirit and scope of the inventions. Further, it is contemplated that any single feature or any combination of optional features of the inventive variations described herein may be specifically excluded from the claimed inventions and be so described as a negative limitation. Accordingly, it is not intended that the inventions be limited, except as by the appended claims.
Claims (38)
1. An amorphous form of a salt of esomeprazole.
2. The amorphous form of a salt of esomeprazole of claim 1 , wherein a cation is selected from the group consisting Na, Mg, Li, K, Ca, and N(R)4, where R is a hydrogen or an alkyl group with 1-4 carbon atoms.
3. The amorphous form of a salt of esomeprazole of claim 2 , wherein the cation comprises Na.
4. The amorphous form of a salt of esomeprazole of claim 2 , wherein the cation comprises Mg.
5. The amorphous form of a salt of esomeprazole of claim 2 , wherein the cation comprises K.
6. The amorphous form of a salt of esomeprazole of claim 2 , wherein the cation comprises Ca.
7. The amorphous form of a salt of esomeprazole of claim 1 , wherein the esomeprazole salt has the X-ray diffraction pattern of a plain halo.
8. (Cancelled).
9. A pharmaceutical composition comprising:
a therapeutically effective amount of an amorphous form of a salt of esomeprazole; andone or more pharmaceutically acceptable carriers, excipients or diluents.
10. The pharmaceutical composition of claim 9 , wherein a cation is selected from the group consisting of Na, Mg, Li, K, Ca, and N(R)4, where R is a hydrogen or an alkyl group with 1-4 carbon atoms.
11. The pharmaceutical composition of claim 10 , wherein the cation comprises Na.
12. The pharmaceutical composition of claim 10 , wherein the cation comprises Mg.
13. The pharmaceutical composition of claim 10 , wherein the cation comprises K.
14. The pharmaceutical composition of claim 10 , wherein the cation comprises Ca.
15. The pharmaceutical composition of claim 10 , wherein the esomeprazole salt has the X-ray diffraction pattern of a plain halo of FIG. 1.
16. (Cancelled)
17. A process for the preparation of a salt of the amorphous form of esomeprazole, the process comprising:
preparing a solution of a salt of esomeprazole in one or more solvents; and
recovering the salt of esomeprazole in the amorphous form from the solution thereof by the removal of the solvent.
18. The process of claim 17 , wherein a cation is selected from the group consisting of Na, Mg, Li, K, Ca, and N(R)4, where R is a hydrogen or an alkyl group with 1-4 carbon atoms.
19. The process of claim 18 , wherein the cation comprises Na.
20. The process of claim 18 , wherein the cation comprises Mg.
21. The process of claim 18 , wherein the cation comprises K.
22. The process of claim 18 , wherein the cation comprises Ca.
23. The process of claim 17 , wherein the solvent comprises one or more of lower alkanol, ketone, ester, chlorinated solvent, acetonitrile or mixtures thereof.
24. The process of claim 23 , wherein the lower alkanol comprises one or more of primary, secondary and tertiary alcohol having from one to six carbon atoms.
25. The process of claim 23 , wherein the lower alkanol comprises one or more of methanol, ethanol, denatured spirit, n-propanol, isopropanol, n-butanol, isobutanol, and t-butanol.
26. The process of claim 23 , wherein the lower alkanol comprises one or more of methanol, ethanol, and denatured spirit.
27. The process of claim 23 , wherein the ketone comprises one or more of acetone, 2-butanone, and 4-methylpentan-2-one.
28. The process of claim 23 , wherein the ester comprises one or more of ethyl acetate and n-butyl acetate.
29. The process of claim 23 , wherein the chlorinated solvent comprises one or more of chloroform and dichloromethane.
30. The process of claim 17 , wherein removing the solvent comprises one or more of distillation, distillation under vacuum, evaporation, spray drying, and freeze drying.
31. The process of claim 17 , wherein the salt of esomeprazole in an amorphous form is recovered from the solution by spray drying.
32. The process of claim 17 , wherein the salt of esomeprazole in an amorphous form is recovered from the solution by freeze-drying.
33. The process of claim 17 , further comprising additional drying of the product obtained.
34. The process of claim 17 , further comprising forming the product obtained into a finished dosage form.
35. The process of claim 17 , further comprises adding one or both of an organic amine and ammonia to the solution.
36. The process of claim 36 , wherein the organic amine and/or ammonia is added to the solution prior to removal of the solvent.
37. The process of claim 17 , wherein the amorphous esomeprazole salt obtained has the X-ray diffraction pattern of a plain halo.
38. (Cancelled).
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US11/946,193 US7482463B2 (en) | 2002-10-22 | 2007-11-28 | Amorphous form of esomeprazole salts |
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EP (1) | EP1556043A1 (en) |
CN (1) | CN1728997A (en) |
AU (1) | AU2003278406A1 (en) |
BR (1) | BR0315574A (en) |
EA (1) | EA200500673A1 (en) |
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WO (1) | WO2004037253A1 (en) |
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US20070149573A1 (en) * | 2005-12-23 | 2007-06-28 | Savanovic Lidija V | S-omeprazole magnesium |
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US20090197919A1 (en) * | 2006-06-07 | 2009-08-06 | Rolf Bergman | Novel Method for Preparation of Ammonium Salts of Esomeprazole |
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Also Published As
Publication number | Publication date |
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NO20052474L (en) | 2005-05-23 |
EP1556043A1 (en) | 2005-07-27 |
NO20052474D0 (en) | 2005-05-23 |
BR0315574A (en) | 2005-09-20 |
US7482463B2 (en) | 2009-01-27 |
US20080119654A1 (en) | 2008-05-22 |
WO2004037253A1 (en) | 2004-05-06 |
EA200500673A1 (en) | 2005-12-29 |
CN1728997A (en) | 2006-02-01 |
AU2003278406A1 (en) | 2004-05-13 |
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