US20050064391A1 - Lectin compositions and methods for modulating an immune response to an antigen - Google Patents

Lectin compositions and methods for modulating an immune response to an antigen Download PDF

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US20050064391A1
US20050064391A1 US10/668,073 US66807303A US2005064391A1 US 20050064391 A1 US20050064391 A1 US 20050064391A1 US 66807303 A US66807303 A US 66807303A US 2005064391 A1 US2005064391 A1 US 2005064391A1
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ligand
cell
cell surface
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receptor
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Andrew Segal
Elihu Young
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OPSANITX LLC
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Genitrix LLC
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5152Tumor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Definitions

  • an adjuvant in admixture with the antigen in order to initiate and/or direct the modulation.
  • Traditional adjuvants have a number of weaknesses. For example, many are crude, heterogeneous preparations. In addition, many are relatively weak immunomodulators, and some cause severe local inflammation that is unacceptable in humans. Purified soluble polypeptides, such as cytokines, have some advantages over crude adjuvants, but their value is limited because they diffuse away from the antigen upon administration. While certain cell-surface molecules may be potential immunomdulators as components of cell-based vaccines, their application generally involves gene transfer into the cells, which is often problematic.
  • the invention therefore fills heretofore unmet needs by providing molecules that can bind to antigen bearing targets, such as cells, viruses, and isolated antigens, and that can serve as immunomodulators when administered with an antigen bearing target.
  • antigen bearing targets such as cells, viruses, and isolated antigens
  • the invention provides compositions comprising these molecules and related methods.
  • the compositions and methods of the invention are also useful for other applications, e.g. any application in which it is desirable to attach a biological effeector, such as a polypeptide ligand for a cell surface receptor, to a target structure, such as a virus or a cell.
  • the present invention relates to a multifunctional molecule, e.g. a fusion polypeptide, comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell.
  • the first part is a first cell surface binding moiety and the second part is a second cell surface binding moiety.
  • the first cell surface binding moiety can attach to a virus or cell, e.g. a tumor cell, which comprises an antigen.
  • the second cell surface binding moiety can bind to a cell-surface polypeptide, e.g. a non-immunoglobulin polypeptide, of an antigen presenting cell (APC).
  • a multifunctional molecule of the invention can serve as a bridge or link between an antigen bearing target and an APC.
  • an “antigen bearing target” is an entity which comprises an antigen.
  • an “antigen bearing target” includes, for example, a whole cell which expresses an antigen a cell fraction comprising an antigen, a membrane fraction comprising an antigen, a virus comprising an antigen, a viral particle comprising an antigen, or an antigen, e.g. a polypeptide antigen, which may be free of any other cell-derived or virus-derived material.
  • Cellular fractions may be prepared using methods known to those of skill in the art such as those taught in Cell Biology A Laboratory Handbook (Academic Press 1994 Editor J. E. Celis ISBN 0-12-164715-3)
  • antigen refers to a molecule against which a subject can initiate a humoral and/or cellular immune response.
  • Antigens can be any type of biologic molecule including, for example, simple intermediary metabolites, sugars, lipids, and hormones as well as macromolecules such as complex carbohydrates, phospholipids, nucleic acids and proteins.
  • Common categories of antigens include, but are not limited to, viral antigens, bacterial antigens, fungal antigens, protozoa and other parasitic antigens, tumor antigens, antigens involved in autoimmune disease, allergy and graft rejection, and other miscellaneous antigens.
  • the antigen is a polypeptide, e.g., one comprising at least seven amino acids.
  • antigen presenting cell refers to cells that ingest and present antigen to T cells. These cells include phagocytic leukocytes, macrophages, and dendritic cells, B lymphocytes, and endothelial cells.
  • a “professional APC” is an APC that is constitutively able to activate a T lymphocyte. Professional APCs typically constitutively express class II major histocompatibility molecules and costimulatory molecules such as B7-1 and/or B7-2.
  • the invention encompasses a multifunctional molecule, the first part of which is a lectin.
  • the multifunctional molecule can bind to one or more carbohydrates of an antigen bearing target.
  • the first part of the multifunctional molecule is a lectin and the second portion is a ligand for a cell surface protein (e.g., a ligand for a cell surface receptor).
  • the cell surface protein is a cell surface receptor of an APC.
  • Ligands for a cell surface receptor include any ligand which will bind to a cell surface protein, and preferably include, but are not limited to, an opsonin, cytokine, adhesion molecule, counterreceptor of a T cell costimulatory molecule, a defensin, a ligand for a CD40 molecule, or a heat shock protein, or a portion of any of these ligands, including about (or at least about) 5, 8, 10, 12, 15, 20, 25, 35, 50, 60, 70, 80, 100, or 120 contiguous amino acids of such a ligand.
  • the multifunctional molecule which comprises first and second parts comprises an amino acid sequence which can bind to a cell surface protein (e.g., a cell surface receptor) including, but not limited to an adhesion molecule, a costimulatory molecule for a T cell, or a receptor for at least one of the following types of molecules: a cytokine, a defensin, a heat shock protein, a CD40 molecule, or an opsonin.
  • a cell surface protein e.g., a cell surface receptor
  • a cell surface protein e.g., a cell surface receptor
  • a cell surface protein useful in the present invention is any cell surface molecule which can bind the ligand portion of a multifunctional molecule of the invention.
  • the cell surface receptor is a CD40 molecule, a T cell costimulatory molecule, an adhesion molecule, or a receptor for a cytokine, a defensin, a heat shock protein, an opsonin, or an adhesion molecule.
  • Cell surface proteins, useful in the invention include, but are not limited to the cell surface molecules identified by GenBank Accession number in Appendix I and II, or those cell surface molecules which are encoded by a nucleic acid molecule identified by GenBank Accession number in Appendix I or II.
  • cytokine refers to a polypeptide molecule that is naturally secreted by mammalian cells and that binds to a cell surface protein on a leukocyte, inducing a change (e.g., a change in the proliferative state, a change in the transcriptional profile or a change in the propensity to migrate) in the leukocyte (other than mere occupancy of the leukocyte's receptors for the cytokine).
  • Change refers to at least about a 5% increase or decrease as compared to in the absence of a cytokine.
  • cytokine also refers herein to a polypeptide molecule that is a ligand for a receptor for a naturally occurring cytokine.
  • cytokines which are useful in the methods and compositions of the invention include the following: GM-CSF, Il-2, IL-4, IL-6, IL-12, ligands for hematopoietin receptors, ligands for immunoglobulin superfamily receptors, ligands for interferon receptors, ligands for TNF receptors, and ligands for chemokine receptors.
  • An antibody against a cytokine receptor can also be a cytokine.
  • a cytokine comprised by a composition of the invention promote a Th1 immune response, i.e., the generation of T cells that express Th1 cytokines such as IL-2 and IFN- ⁇ .
  • a cytokine comprised by a composition of the invention promote a Th2 immune response, i.e., the generation of T cells that express Th2 cytokines such as IL-4 and IL-10.
  • cytokines as described herein are cytokines which comprise a heterologous cell surface binding moiety.
  • opsonin refers to naturally occurring and non-naturally occurring molecules which are capable, by virtue of being contemporaneously bound or attached to both an antigen-containing cell and an antigen-presenting cell (APC), of acting as a link or coupling agent (an adapter) between the antigen and the APC to allow more efficient binding, engulfment, and internalization of the antigen-containing cell by the APC.
  • An opsonin useful according to the invention also includes non-naturally occurring opsonins capable of binding to APCs via receptors that can bind naturally occurring opsonins.
  • opsonin can also refer to molecules which can be processed such that at least one product of the processing step or steps is capable of, by virtue of being contemporaneously bound or attached to both an antigen-containing cell and an APC, acting as a link or coupling agent to allow more efficient binding, engulfment, and internalization of other antigen-containing cells by the APC.
  • An opsonin can also be any polypeptide chain of a multichain opsonin.
  • opsonins which are useful in the methods and compositions of the invention include the following: vitronectin, fibronectin, complement components such as C1q (including any of its component polypeptide chains A, B and C), complement fragments such as C3d, C3b and C4b, mannose binding protein, conglutinin, surfactant proteins A and D, C-reactive protein (CRP), alpha-2-macroglobulin, and immunoglobulins, for example, the Fc portion of an immunoglobulin.
  • “Innate opsonins” are opsonins of the innate immune system and are known in the art as secreted polypeptide molecules of the innate immune system and are believed to bind contemporaneously to an antigen and to the surface of an APC. They can thus act as “bridges”, and are thought, by virtue of this property, to promote internalization of antigens by APCs.
  • the mode in which opsonins bind to antigens varies among opsonins, and can be covalent or noncovalent.
  • the antigen-binding moieties of innate opsonins differ from the antigen-binding moieties of immunoglobulins in that the former are relatively invariant among members of the same species, and do not undergo diversification during the ontogeny of an individual.
  • a molecule containing a naturally occurring APC-binding moiety shall be considered an opsonin if it contains a moiety through which it can be stably bound or attached to a cell such that the APC-binding moiety is located in the extracellular space, whether or not the opsonin molecule contains its natural antigen-binding domain.
  • “Engineered opsonins”, as described herein, include molecules in which a cell surface binding moiety is substituted for the natural antigen-binding domain of an opsonin or where a cell surface binding moiety is linked to the opsonin without modification or removal of the natural antigen-binding domain of the opsonin.
  • a “cell surface binding moiety” is a moiety through which a molecule can be stably bound to a cell surface, e.g. a cell wall, a polysaccharide capsule, or the lipid or protein component of a plasma membrane, or to the surface of a virus.
  • Such moieties include but are not limited to crosslinking moieties and lipid moieties. It is preferred that the cell surface binding moiety bind to a cell by a means other than interaction of a polypeptide with its cognate cell-surface polypeptide. It is further preferred that the cell surface binding moiety comprise a non-polypeptide moiety.
  • a lipid moiety is linked to the engineered molecule via a glycosylphosphatidylinositol (GPI) moiety.
  • the lipid comprises a fatty acid, e.g. palmitate.
  • the cell surface binding moiety is linked to an opsonin or an antigen-binding domain-truncated opsonin at the antigen-binding end of the opsonin.
  • the multifunctional molecule comprises an idiotypic portion of an immunoglobulin which can bind to an APC.
  • the opsonin of an opsonin-enhanced cell is one of alpha′ chain C3b or mannose binding protein.
  • the opsonin is a fragment of C3, it is preferred hat it bind to CR1 with a greater affinity than to CR2. It is further preferred that the fragment of C3 not be a ligand for CR2. Preferably, the opsonin is neither C3bi, C3d, nor C3dg.
  • the opsonins bind to receptors that trigger phagocytosis and that are non-clonotypic and thus do not vary from cell to cell as, for example, clonotypic receptors do.
  • Non-clonotypic receptors are present on cells which play a role in innate immunity, and include, e.g., non-idiotypic receptors. Examples of such receptors include CR1, CR2, CR3, CR4, and C1q receptor, receptors containing a component of the C1q receptor, collectin receptors, receptors for ⁇ 2m, receptors for CRP, and Fc receptors for immunoglobulins.
  • Exogenous refers to something which is introduced from or produced outside the cell.
  • Endogenous refers to something which is expressed or present naturally in a cell.
  • Heterologous refers to something which is not naturally expressed in a cell.
  • the multifunctional molecule which comprises first and second parts can bind, via the second part, to the surface or plasma membrane of an antigen presenting cell (APC), i.e. a cell that can present antigen to a T cell, e.g. a cell that can activate a T cell, at least in part by presenting antigen to the T cell.
  • APC antigen presenting cell
  • the APC may be a leukocyte, e.g. a cell of monocytic lineage and/or a dendritic cell.
  • binding of the multifunctional molecule is independent of expression of an idiotype, e.g. a clonotypic determinant of an immunoglobulin, on the APC.
  • the multifunctional molecule comprises a first end which can bind to a cell that comprises an antigen and a second end which can bind to a APC.
  • the multifunctional molecule may bind to an antigen bearing target cell by, e.g., inserting into the lipid portion of a cell membrane or by binding to a structure, e.g. a polypeptide or a carbohydrate, that is physically associated with the lipid portion of the membrane.
  • the structure need not be directly in contact with the lipid portion of the membrane, but may be indirectly attached, e.g. a carbohydrate that is part of a cell-surface glycoprotein.
  • the multifunctional molecule can bind via a first part to an antigen bearing target, preferably a mammalian cell that comprises an antigen, and via a second part to an APC.
  • the invention also encompasses the use of a molecule that can bind via a first part to a virus or to a non-mammalian cell, e.g. a fungal or bacterial cell, and via a second part to an APC.
  • the first part may bind, e.g., to a component of a cell wall or a capsule.
  • the multifunctional molecule which comprises first and second parts comprises a first part which comprises a lectin and a second part that can bind to a leukocyte, e.g. an APC, e.g. a cell of monocytic lineage or a dendritic cell (which may itself be of monocytic lineage).
  • a “lectin”, according to the invention is a molecule or part of a molecule, e.g. an amino acid sequence, which can bind to a carbohydrate, e.g. a polysaccharide. Families of naturally occurring lectins include:
  • a multifunctional molecule of the invention may bind to one or more carbohydrates.
  • Carbohydrates to which lectins may bind also include, for example, carbohydrates comprising lactose, D-mannose, D-glucose, D-fucose, L-fucose (e.g.
  • alpha-L-fucose D-galactose
  • blood group A oligosaccharides
  • blood group B oligosaccharides
  • saccharides comprising alpha-D-Gal(1->3)[alpha-Lfuc(1->2)]-beta-D-Gal(1->3/4-beta-D-GlcNAc
  • saccharides comprising alpha-sialyl [2->3]-lactose, alpha-D-mannosyl glycoconjugates, alpha-NeuNAc-[2->6]-Gal, alpha-NeuNAc-[2->6]-GalNAc, alpha-NeuNAc-[2->3]-Gal, N-acetyl-beta-D-glucosamine, terminal alpha-D-galactosyl residues, terminal beta-D-galactosyl residues, N-acetyllactosamine, terminal alpha-D-man
  • the multifunctional molecule which comprises a lectin may comprise, for example, the whole of a naturally occurring lectin or a portion of a naturally occurring lectin, e.g about (or at least about) 5, 8, 10, 12, 15, 20, 25, 35, 50, 60, 70, 80, 100, or 120 contiguous amino acids of a naturally occurring polypeptide lectin.
  • the multifunctional molecule comprises a carbohydrate-binding domain of a naturally occurring lectin, i.e., a portion of a lectin that can bind to a carbohydrate in the absence of the remainder of the lectin.
  • the lectin may be non-naturally occurring, e.g. identified from an artificial library of molecules or designed by modifying the structure of a naturally occurring lectin.
  • hemagglutinins bind to carbohydrates on erythrocytes, e.g. blood group antigens, and when incubated with these cells cause them to aggregate.
  • the influenza virus hemagglutinin for example, binds to sialic acid (as does the human parainfluenza virus 3 hemagglutinin/neuraminidase).
  • the hemagglutinin is of a subtype from a virus that infects humans, e.g. H1, H2, or H3.
  • the hemagglutinin is of a subtype from a virus that does not infect humans, e.g. one of H4 through H15.
  • Amino acid sequences can vary up to about 20% for influenza hemagglutinins within a given subtype, and can vary between about 30% and about 70% for influenza hemagglutinins from different subtypes.
  • Influenza hemagglutinin is expressed as a single polypeptide chain, designated HA0, which trimerizes post-translationally.
  • HA0 is proteolytically cleaved to yield two domains, HA1 and HA2, which are disulfide-bonded to each other.
  • HA1 comprises significant sialic acid binding activity, while HA2 is anchored to the viral membrane and facilitates fusion of this membrane with a host cell membrane.
  • the multifunctional molecule comprising first and second parts comprises an amino acid sequence of an HA1 domain.
  • the molecule may be a fusion polypeptide which comprises one or more amino acids interposed between the first and second parts which bind to cells, e.g. a fusion polypeptide which comprises a first amino acid sequence which can bind to an antigen bearing target and a second amino acid sequence which can bind to a leukocyte, and which further comprises at least one amino acid interposed between the first and second parts.
  • the interposed amino acids may comprise, e.g., a linker sequence intended to lessen steric hindrance or other undesirable interactions between the aforementioned first and second parts.
  • one such type of sequence takes the form (Gly 3 Ser) n .
  • Additional useful linkers include, but are not limited to (Arg-Ala-Arg-Asp-Pro-Arg-Val-Pro-Val-Ala-Thr) 1-5 (Xu et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96: 151-156), (Gly-Ser) n (Shao et al., 2000, Bioconjug. Chem. 11: 822-826), (Thr-Ser-Pro), (Kroon et al., 2000, Eur. J. Biochem.
  • the present invention further provides a nucleic acid molecule, preferably a recombinant nucleic acid molecule which encodes a multifunctional polypeptide of the present invention.
  • the nucleic acid molecule may be, for example, DNA, RNA, cDNA, or mRNA.
  • the nucleic acid molecule may be naturally occuring or may be partially or wholly synthesized using techniques known to those of skill in the art.
  • the nucleic acid molecule is a DNA molecule comprising a first nucleic acid sequence encoding a first amino acid sequence which can bind to an antigen bearing target, and a second nucleic acid sequence encoding a second amino acid sequence which can bind to a cell surface receptor on an APC.
  • the present invention still further provides a vector comprising the nucleic acid molecule encoding a multifunctional polypeptide of the invention, e.g. an expression vector suitable for expressing in a host cell, wherein the host cell is preferably a eukaryotic cell, more preferably an animal cell, more preferably a mammalian cell, and still more preferably a human cell.
  • the host cell is a yeast cell, e.g. Saccharomyces cerevesiae.
  • the invention also provides a host cell comprising a nucleic acid vector which comprises a sequence encoding the multifunctional molecule of the present invention.
  • the host cell is a eukaryotic cell, such as a yeast cell- or an animal cell, preferably a human cell.
  • the host cell may also be a prokaryotic cell.
  • the invention also encompasses a molecule, e.g. a polypeptide, e.g. a fusion polypeptide, which comprises a first part that can bind to an antigen bearing target, e.g. a cell, e.g. a cell that comprises an antigen, and a second part that can bind to a cell, e.g. a leukocyte, e.g. an APC.
  • the molecule may have any of the characteristics taught in the descriptions of methods and compositions herein.
  • the first and second parts are heterologous to each other.
  • the molecule may be, e.g., a recombinant polypeptide expressed in a mammalian cell, an insect cell, a plant cell, a yeast cell, or a bacterial cell.
  • the invention also encompasses a method of modulating an immune response in an animal comprising the step of expressing in an animal, e.g. expressing in a host cell of the animal, a multifunctional molecule of the invention, e.g. a polypeptide which comprises a first part that can bind to a antigen bearing target and a second part that can bind to a cell.
  • a multifunctional molecule of the invention e.g. a polypeptide which comprises a first part that can bind to a antigen bearing target and a second part that can bind to a cell.
  • “expressing in an animal” means “causing to be present in an animal”.
  • the molecule is preferably expressed by introducing into the host cell, in vivo or ex vivo, a nucleic acid encoding the polypeptide.
  • the host cell may subsequently be administered to the animal.
  • the method further comprises administering to the animal the antigen to which the immune response is modulated.
  • the antigen may be administered to the animal as part of a composition which further comprises a nucleic acid that encodes the multifunctional molecule.
  • the antigen is already present in the animal at the time the multifunctional molecule is expressed.
  • the antigen is administered to the animal after administration of the multifunctional molecule.
  • the antigen is expressed in the animal, e.g.
  • nucleic acid sequences encoding the multifunctional molecule and the antigen are introduced into one or more host cells of the animal, e.g. by administering to the animal a composition comprising those nucleic acid sequences.
  • the term “modulating an immune response” to a selected antigen using the methods and compositions of the invention means rendering the response more or less efficient, more or less rapid, greater or lesser in magnitude, and/or more or less easily induced than the response obtained from administration of a composition which is identical in every respect except that it does not comprise a multifunctional molecule of the invention.
  • the response is between about 5 and 100%, or preferably between about 5 and 50% or more preferably between about 5 and 25% more or less efficient, more or less rapid, greater or lesser in magnitude, and/or more or less easily induced than the response obtained from administration of a composition which is identical in every respect except that it does not comprise a multifunctional molecule of the invention.
  • modulate the immune response may refer to stimulation/activation of an immune response to a selected antigen, or it may refer to suppression, elimination, or attenuation of an immune response to a selected antigen.
  • modulating the immune response results in stimulation/activation of an immune response to a selected antigen by about at least 5%, or preferably between 5 and 50% or more preferably between 50 and 100%, as compared to an immune response in the absence of vaccination, or it may result in suppression, elimination, or attenuation of an immune response to a selected antigen by about at least 5%, or preferably between 5 and 50% or more preferably between 50 and 100%, as compared to an immune response in the absence of vaccination.
  • one immune response to an antigen e.g. a Th1 response
  • another immune response to the same antigen e.g. a Th2 response
  • the invention also encompasses a composition comprising a multifunctional molecule of the invention and antigen bearing target, e.g. a virus, a prion, or a cell.
  • antigen bearing target e.g. a virus, a prion, or a cell.
  • the multifunctional molecule is exogenous to the cell.
  • the multifunctional molecule may be heterologous to the cell.
  • the multifunctional molecule is expressed within the cell, e.g. from a recombinant nucleic acid within the cell.
  • the invention also encompasses a cell comprising a nucleic acid encoding a multifunctional molecule of the invention.
  • the multifunctional molecule may have any of the characteristics set forth herein.
  • An antigen bearing target e.g., a cell
  • a cell includes, for example, malignant cells, benign tumor cells, lymphocytes, e.g. B or T lymphocytes which may be pathogenic and/or autoreactive, cells expressing an antigen from an exogenously introduced nucleic acid molecule, eukaryotic cells such as mammalian cells, human cells, fibroblasts, insect and fungal cells, and prokaryotic cells such as bacterial cells.
  • viruses useful in the invention include, e.g., retroviruses such as human immunodeficiency viruses 1 and 2; herpesviruses such as herpes simplex viruses 1 and 2, cytomegalovirus, and varicella zoster virus; human papilloma virus; rabies virus; rotavirus; influenza viruses A, B, and C; hepatitis viruses A, B, C, and E or delta agent; adenoviruses; measles virus; mumps virus; polio virus; rubella virus; parainflunza viruses; coxsackie viruses A and B; variola virus; yellow fever virus; dengue and other hemorrhagic fever viruses; West Nile fever virus; Eastern equine encephalitis virus; Western equine encephalitis virus; Venezuelan equine encephalitis virus; Japanese encephalitis virus; rhinoviruses; and foot and mouth disease virus.
  • retroviruses such as human immunodeficiency viruses 1 and 2
  • Prions include the agents of scrapie, kuru, and bovine spongiform encephalitis.
  • the cell, virus, or prion may be attenuated, i.e. rendered non-pathogenic, by, e.g, killing, irradiation, chemical fixation, passaging in culture with selection for diminished pathogenicity, or genetic manipulation.
  • the composition further comprises a leukocyte, e.g. a monocyte, a cell of monocytic lineage, a macrophage, or a dendritic cell or another APC.
  • the cell is substantially unable to divide in vitro. “Substantially unable to divide in vitro” means that the cell divides at a rate that is less than about 50% of the rate of division of corresponding cells which are not treated to prevent cell division. In a preferred embodiment, the cell divides at a rate that is less than about 30-50% of the rate of division of corresponding cells which are not treated to prevent cell division.
  • the composition is substantially free of culture medium.
  • culture medium refers to medium that is used in cell culture containing at least 2% animal serum, such as fetal calf serum.
  • the present invention provides a multifunctional molecule which is a fusion polypeptide comprising: a lectin which comprises at least about 10 contiguous amino acids of an influenza virus hemagglutinin, and at least about 5 contiguous amino acids of a naturally occurring GM-CSF molecule.
  • the lectin is N-terminal to the contiguous amino acids of a naturally occurring GM-CSF molecule.
  • the lectin is C-terminal to the contiguous amino acids of a naturally occurring GM-CSF molecule.
  • the lectin comprises at least about 10 contiguous amino acids of the HA1 domain of an influenza virus hemagglutinin.
  • the lectin is the HA1 domain of an influenza virus hemagglutinin.
  • influenza virus hemagglutinin is a hemagglutinin of an influenza A virus.
  • influenza virus hemagglutinin is a hemagglutinin of an influenza B or influenza C virus.
  • influenza virus hemagglutinin is of a subtype from a virus that infects humans.
  • influenza virus hemagglutinin is of an H1 subtype.
  • influenza virus hemagglutinin is from the influenza A strain PR/8/34.
  • influenza virus hemagglutinin is of an H2 subtype.
  • influenza virus hemagglutinin is of an H3 subtype.
  • influenza virus hemagglutinin is of a subtype from a virus that does not infect humans.
  • the fusion polypeptide comprises the entire amino acid sequence of a naturally occurring GM-CSF molecule.
  • the GM-CSF molecule is a murine GM-CSF. Still more preferably, the GM-CSF molecule is a human GM-CSF.
  • the invention encompasses a method of reducing the number of metastases, e.g. tumor metastases, in a subject, e.g. a mammal, e.g. a human, comprising the step of administering to the subject any of the compositions described herein, e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention.
  • a composition will further comprise an antigen associated with the disease, or a nucleic acid encoding such an antigen.
  • the method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein.
  • the invention provides, a method of reducing the number of metastasis in an animal comprising administering to said animal a composition comprising a cell comprising an antigen, said composition further comprising a fusion protein comprising a lectin and a ligand for a cell surface protein.
  • a “metastasis” refers to a focus of disease that is caused by a malignent cell or infectious organism which has traveled from one site in a host to a second site in the host (e.g., from one site to a non-contiguous site; e.g., from a first organ to a second organ). More specifically, “metastasis” refers to a detectable focus of malignant tumor or infection that is derived from, and spread from, and is distinct from the primary site of disease. Accordingly, “metastases” refers to a plurality of foci either in a single organ or tissue in a subject, or in two or more organs or tissues in a subject.
  • a “focus” as used herein may be at least a single malignant or infectious cell, or may be a detectable focus, which is detectable by one or more of the methods described hereinbelow. Metastases is said to be detected where a metastases is able to be detected by one of skill in the art using one or more of the assay methods described hereinbelow.
  • “reducing the number of metastases” may mean either causing there to be fewer (e.g., at least 10% fewer, 20%, 30%, 50%, 70%, 90%, and up to at least 100% fewer) metastases than expected (where the number or severity of metastases expected is based on the observations made in a set (e.g., more than one) or similar subjects which has not received the multifunctional molecule of the invention).
  • “reducing the number of metastases” may encompass preventing metastases (e.g. a subject does not develop any detectable foci of disease), e.g. in a subject with a tumor, or causing one or more preexisting metastases to become undetectable, e.g.
  • Metastases may be, for example, to bone, brain, liver, lung, or spinal cord, or any other organ or tissue.
  • the invention encompasses a method of reducing the number of metastases in a population of subjects comprising the step of administering to one or more subjects any of the compositions described herein e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention.
  • a composition will further comprise an antigen associated with the disease, or a nucleic acid encoding such an antigen.
  • the method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein.
  • the invention encompasses a method of reducing the size of a metastasis in a subject comprising the step of administering to the subject any of the compositions described herein, e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention.
  • a composition will further comprise an antigen associated with the disease, or a nucleic acid encoding such an antigen.
  • the method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein.
  • the “size” of a metastasis refers to the one, two or three dimensional area encompassed by a metastasis, or alternatively, refers to the number of malignant or infectious cells present in a metastasis.
  • the size of the metastasis which may be measured by direct visualization or by noninvasive imaging, may be reduced by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%.
  • the invention provides a method of reducing the size of a metastasis in an animal comprising administering to said animal a composition comprising a cell comprising an antigen, said composition further comprising a fusion protein comprising a lectin and a ligand for a cell surface protein.
  • the invention encompasses a method of reducing the average size of metastases in a subject comprising the step of administering to the subject any of the compositions described herein.
  • the method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein.
  • “reducing the average size of metastases” may mean either causing metastases to be smaller on average than expected, e.g. by preventing one or more of them from growing to the expected size, or causing one or more preexisting metastases to become smaller, thus decreasing the mean size of the metastases.
  • the average size of the metastases which may be determined by direct visualization or by noninvasive imaging, may be reduced by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%.
  • the invention encompasses a method of reducing the average size of metastases in a population comprising the step of administering to one or more subjects any of the compositions described herein, e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention.
  • the method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein.
  • the invention encompasses preventing or treating a disease in a subject by administering to the subject any of the compositions described herein, e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention.
  • a composition will further comprise an antigen associated with the disease, or a nucleic acid encoding such an antigen.
  • the disease may be, for example, a benign or malignant tumor, an infectious disease, an allergy, or an autoimmune disease. “Treating a disease” means decreasing morbidity or mortality associated with the disease in a patient or population afflicted with the disease.
  • survival, relapse-free survival, or disease-free survival may be prolonged by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%, or the number of metastases may be reduced by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%.
  • the incidence of the targeted disease may be reduced by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%.
  • the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising the antigen and not comprising (i.e. free of) the multifunctional molecule administered in step 1.
  • the two steps will be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart.
  • the composition comprising the multifunctional molecule is administered to the subject prior to the composition which is free of the multifunctional molecule. In another embodiment, the composition which is free of the multifunctional molecule is administered to the subject prior to the composition which comprises the multifunctional molecule.
  • the antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle.
  • the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising the antigen and further comprising a nucleic acid molecule encoding a multifunctional molecule of the invention and 2) administering to the subject a composition comprising the antigen and not comprising (i.e. free of) the nucleic acid molecule administered in step 1.
  • the two steps will generally be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart.
  • the composition comprising the nucleic acid molecule is administered to the subject prior to the composition which is free of the nucleic acid molecule. In another embodiment, the composition which is free of the nucleic acid molecule is administered to the subject prior to the composition which comprises the nucleic acid molecule.
  • the antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle.
  • the nucleic acid molecule may be comprised by an expression vector.
  • the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and not comprising (i.e. free of) the multifunctional molecule administered in step 1.
  • the two steps will be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart.
  • the composition comprising the multifunctional molecule is administered to the subject prior to the composition which is free of the multifunctional molecule. In another embodiment, the composition which is free of the multifunctional molecule is administered to the subject prior to the composition which comprises the multifunctional molecule.
  • the antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle.
  • One or more of the nucleic acid molecules may be comprised by an expression vector.
  • the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and not comprising (i.e. free of) the multifunctional molecule administered in step 1.
  • the two steps will be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart.
  • the composition comprising the multifunctional molecule is administered to the subject prior to the composition which is free of the multifunctional molecule. In another embodiment, the composition which is free of the multifunctional molecule is administered to the subject prior to the composition which comprises the multifunctional molecule.
  • the antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle.
  • the nucleic acid molecule may be comprised by an expression vector.
  • the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising the antigen and not comprising (i.e. free of) the multifunctional molecule administered in step 1.
  • the two steps will be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or a least 1 year apart.
  • the composition comprising the multifunctional molecule is administered to the subject prior to the composition which is free of the multifunctional molecule. In another embodiment, the composition which is free of the multifunctional molecule is administered to the subject prior to the composition which comprises the multifunctional molecule.
  • the antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle.
  • the nucleic acid molecule may be comprised by an expression vector.
  • the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a nucleic acid molecule encoding a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and not comprising (i.e. free of) the nucleic acid molecule encoding the multifunctional molecule, which was administered in step 1.
  • the two steps will generally be performed sequentially, e.g.
  • the composition comprising the nucleic acid molecule is administered to the subject prior to the composition which is free of the nucleic acid molecule encoding the multifunctional molecule. In another embodiment, the composition which is free of the nucleic acid molecule encoding the multifunctional molecule is administered to the subject prior to the composition which comprises the nucleic acid molecule encoding the multifunctional molecule.
  • One or more of the nucleic acid molecules may be comprised by an expression vector.
  • the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a nucleic acid molecule encoding a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a multifunctional molecule of the invention.
  • the multifunctional molecules of step 1 and step 2 may be the same or different. Again, the two steps will generally be performed sequentially, e.g.
  • the composition comprising the nucleic acid molecule is administered to the subject prior to the composition which is free of the nucleic acid molecule encoding the multifunctional molecule. In another embodiment, the composition which is free of the nucleic acid molecule encoding the multifunctional molecule is administered to the subject prior to the composition which comprises the nucleic acid molecule encoding the multifunctional molecule.
  • One or more of the nucleic acid molecules may be comprised by an expression vector.
  • the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a nucleic acid molecule encoding a multifunctional molecule of the invention.
  • the multifunctional molecules of step 1 and step 2 may be the same or different. Again, the two steps will generally be performed sequentially, e.g.
  • the composition comprising the nucleic acid molecule is administered to the subject prior to the composition which is free of the nucleic acid molecule encoding the multifunctional molecule. In another embodiment, the composition which is free of the nucleic acid molecule encoding the multifunctional molecule is administered to the subject prior to the composition which comprises the nucleic acid molecule encoding the multifunctional molecule.
  • One or more of the nucleic acid molecules may be comprised by an expression vector.
  • the present invention encompasses a method of modulating an immune response in an animal comprising the step of administering a composition comprising a multifunctional molecule, e.g. a polypeptide, e.g. a fusion polypeptide, which comprises a first part that can bind to a antigen bearing target and a second part that can bind to a cell.
  • the composition further comprises an antigen, an immune response to which is modulated by administration of the composition.
  • the antigen may be, for example, a polypeptide (e.g. a recombinant polypeptide), a lipid (e.g. a glycolipid), or a carbohydrate (e.g.
  • the composition therefore comprises an antigen bearing target, whether, e.g., a homogeneous antigen or a heterogeneous structure such as a cell or a virus.
  • an antigen bearing target is a cell, it may be autologous, syngeneic, allogeneic, or xenogeneic to the animal.
  • the antigen is already present in the animal at the time the molecule is administered, and/or the antigen is administered to the animal prior to administration of the molecule.
  • the antigen is administered to the animal after administration of the molecule.
  • the composition comprises multifunctional molecules which are not bound to an antigen bearing target.
  • the composition further comprises an antigen bearing target, e.g. a cell.
  • the composition comprises multifunctional molecules, some of which are bound to a antigen bearing target, e.g. to the surface of a cell, and some of which are external to and not bound to any target.
  • the composition comprises a multifunctional molecule and further comprises a portion of a cell, e.g. a membrane fraction of a cell (i.e., an antigen bearing target).
  • the composition comprises a multifunctional molecule and further comprises a multiplicity of different molecules derived from a cell, as is found, e.g., in a cell lysate.
  • Cells may be lysed, for example, by freezing and thawing, preferably repeatedly.
  • the composition is cell-free.
  • the present invention further encompasses a method of vaccinating a mammal to a selected antigen comprising administering to the animal a vaccine composition comprising a multifunctional molecule of the invention comprising a first part which is a lectin, and a second part which is a ligand for a cell surface protein, e.g. a cell surface receptor of an APC.
  • a vaccine composition comprising a multifunctional molecule of the invention comprising a first part which is a lectin, and a second part which is a ligand for a cell surface protein, e.g. a cell surface receptor of an APC.
  • the lectin can bind to an antigen bearing target which comprises the antigen.
  • the invention provides a method of vaccinating a mammal to a selected antigen comprising removing at least one cell from the mammal, wherein the cell comprises the antigen, contacting the cell ex vivo with a multifunctional molecule comprising a first part which is a lectin and is capable of binding to at least one carbohydrate molecule on the surface of the antigen bearing cell, and a second part which is a ligand for a cell surface protein of an APC, so as to form an antigen bearing cell/multifunctional molecule complex; and placing the complex back into the mammal.
  • a multifunctional molecule comprising a first part which is a lectin and is capable of binding to at least one carbohydrate molecule on the surface of the antigen bearing cell, and a second part which is a ligand for a cell surface protein of an APC, so as to form an antigen bearing cell/multifunctional molecule complex; and placing the complex back into the mammal.
  • the composition comprises an antigen, an immune response to which is modulated by administration of the composition.
  • the invention provides a method of modulating an immune response to a selected antigen in a mammal comprising administering to said animal a composition comprising a cell comprising said antigen, and a multifunctional molecule comprising a lectin and a ligand for a cell surface protein.
  • the invention also relates to a method of vaccinating an animal to a selected antigen comprising removing at least one cell from said animal, wherein the cell comprises said antigen; contacting said cell ex vivo with a fusion polypeptide comprising a lecting and a ligand for a cell surface protein of an antigen presenting cell so as to form a complex; and placing said complex back in said animal.
  • the present invention provides a method for juxtaposing an APC with an antigen bearing target comprising: contacting an APC and antigen bearing target with a multifunctional molecule comprising a first part comprising a lectin which is able to bind to at least one carbohydrate moiety on the antigen bearing target and a second part comprising a ligand for a cell surface protein on the APC.
  • the multifunctional molecule is first contacted with the antigen bearing target and the resulting antigen bearing target/multifunctional molecule complex is subsequently contacted with the APC.
  • the antigen bearing target is a cell from an animal comprising an antigen, and is contacted with the multifunctional molecule ex vivo under conditions which permit the binding of the lectin to at least one carbohydrate moiety of the cell.
  • the resulting multifunctional molecule/antigen bearing cell complex is then administered back to the animal from which the antigen bearing cell was derived wherein it is able to bind to a cell surface receptor on an APC via the ligand portion of the multifunctional molecule, thereby juxtaposing the antigen bearing target and the APC.
  • “Juxtaposition”, in the context of the present invention, includes but is not limited to physical contact.
  • An APC and antigen bearing target are “juxtaposed” with one another if they are sufficiently close for the APC to internalize the antigen bearing target.
  • An APC and antigen bearing target are also “juxtaposed” if they are separated by no more that 20 ⁇ m, preferably no more than 10 ⁇ m, and still more preferably no more than 5 ⁇ m, and more preferably no more than 1 ⁇ m.
  • contacting refers to admixing in vitro or in vivo.
  • the invention also encompasses a method of modulating an immune response to an antigen comprising contacting in vitro an antigen bearing target, a multifunctional molecule of the invention, and an APC and administering the resultant composition to a subject.
  • the antigen bearing target/multifunctional molecule complex is contacted with an APC for a time sufficient to permit internalization of the antigen bearing target by the APC.
  • the antigen bearing target/multifunctional molecule complex is contacted with an APC for a time that allows internalization of less than about 80%, less than about 60%, less than about 40%, less than about 20%, less than about 10%, or less than about 5% of the antigen bearing target by the APC.
  • the antigen bearing target/multifunctional molecule complex is contacted with an APC for less than about 10 minutes, less than about 30 minutes, less than about 60 minutes, less than about 90 minutes, less than about 120 minutes, or less than about 180 minutes.
  • time sufficient to permit internalization refers to a period of time that is of a sufficient duration to allow internalization of the selected antigen or antigen bearing targtet by the APC (for example, no more than about fourteen days, or seven days, or five or three days, or as little as about 24, 12, 6, 3, 2 or 1 hour, or even as little as about 30, 20, 10, 5, or 1 minute).
  • the invention also encompasses a method of attaching a ligand for a cell surface polypeptide to an antigen bearing target comprising admixing the antigen bearing target with a multifunctional molecule which comprises the ligand.
  • the invention also encompasses a method of attaching an amino acid sequence to an antigen bearing target comprising admixing the antigen bearing target with a fusion polypeptide which comprises the amino acid sequence and further comprises a lectin.
  • the invention also encompasses a composition comprising an antigen bearing target admixed with a fusion polypeptide which comprises a first amino acid sequence which is not a lectin and a second amino acid sequence which comprises a lectin.
  • the invention also comprises methods of producing a multifunctional molecule of the invention in each of the following cell types: a yeast cell, a mammalian cell, a bacterial cell, an insect cell.
  • Each of these methods comprises the step of introducing a nucleic acid encoding a multifunctional molecule into the respective cell type, as taught hereinbelow.
  • the invention also encompasses methods of detecting or quantifying a multifunctional molecule of the invention comprising contacting the multifunctional molecule with an antibody or other ligand that binds to the multfunctional molecule.
  • Such methods include ELISA assays and flow cytometry, as described hereinbelow.
  • the multifunctional molecule to be detected or quantitated is bound to an antigen bearing target.
  • the present invention is based, in part, on the discovery that a multifunctional fusion protein comprising a first polypeptide which is a lectin and a second polypeptide which is a ligand of a cell surface receptor of an APC, can effectively target an antigen bearing target, such as a cell bearing an antigen of interest, to an APC, wherein the antigen is engulfed by the APC, and an appropriate immune response to the antigen is mounted by an animal to which the multifunctional molecule is administered.
  • an antigen bearing target such as a cell bearing an antigen of interest
  • the present invention provides a method for vaccinating a mammal comprising administering to the animal a vaccine composition comprising a multifunctional molecule of the invention comprising a first part which is a lectin and which can bind to a target bearing the antigen, and a second part which is a ligand for a cell surface protein of an APC.
  • the method comprises removing at least one cell from the mammal, wherein the cell comprises the antigen, contacting the cell ex vivo with a multifunctional molecule comprising a first part which is a lectin and is capable of binding to at lease one carbohydrate molecule on the surface of the antigen bearing cell, and a second part which is a ligand for a cell surface protein of an APC, so as to form an antigen bearing cell/multifunctional molecule complex; and placing the complex back into the mammal.
  • a multifunctional molecule comprising a first part which is a lectin and is capable of binding to at lease one carbohydrate molecule on the surface of the antigen bearing cell, and a second part which is a ligand for a cell surface protein of an APC, so as to form an antigen bearing cell/multifunctional molecule complex; and placing the complex back into the mammal.
  • the present invention encompasses a multifunctional molecule comprising a first part which can bind to an antigen bearing target, and a second part which is a ligand for a cell surface protein of a cell, e.g. an antigen presenting cell.
  • the first part which can bind to an antigen bearing target is a lectin which binds to at least one carbohydrate molecule present on the antigen bearing target.
  • the lectin is an influenza hemagglutinin and binds to sialic acid residues present on the antigen bearing target.
  • the ligand of a cell surface protein of an antigen presenting cell is selected from an opsonin, a cytokine, a ligand for a CD40 molecule, an adhesion molecule, a defensin, a heat shock protein, or a counterreceptor for a T cell costimulatory molecule.
  • Cell surface molecules which can act as receptors for the second part of the multifunctional molecule include CD40 molecules and specific receptors for an opsonin, a cytokine, an adhesion molecule, a defensin, a heat shock protein, or a counterreceptor for a T cell costimulatory molecule, and also include, but are not limited to the cell surface molecules listed in Apendix I and II.
  • the multifunctional molecule which comprises first and second parts can comprise a first part which comprises a lectin and a second part that can bind to a leukocyte, e.g. an APC, e.g. a cell of monocytic lineage or a dendritic cell (which may itself be of monocytic lineage).
  • a “lectin”, according to the invention is a molecule or part of a molecule, e.g. an amino acid sequence, which can bind to a carbohydrate, e.g. a polysaccharide. Families of naturally occurring lectins include:
  • a multifunctional molecule of the invention may bind to one or more carbohydrates.
  • Carbohydrates to which lectins may bind also include, for example, carbohydrates comprising lactose, D-mannose, D-glucose, D-fucose, L-fucose (e.g.
  • alpha-L-fucose D-galactose
  • blood group A oligosaccharides
  • blood group B oligosaccharides
  • saccharides comprising alpha-D-Gal(1->3)[alpha-Lfuc(1->2)]-beta-D-Gal(1->3/4-beta-D-GlcNAc
  • saccharides comprising alpha-sialyl-[2->3]-lactose, alpha-D-mannosyl glycoconjugates, alpha-NeuNAc-[2->6]-Gal, alpha-NeuNAc-[2->6]-GalNAc, alpha-NeuNAc-[2->3]-Gal, N-acetyl-beta-D-glucosamine, terminal alpha-D-galactosyl residues, terminal beta-D-galactosyl residues, N-acetyllactosamine, terminal alpha-D-
  • the multifunctional molecule which comprises a lectin may comprise, for example, the whole of a naturally occurring lectin or a portion of a naturally occurring lectin, e.g about (or at least about) 5, 8, 10, 12, 15, 20, 25, 35, 50, 60, 70, 80, 100, or 120 contiguous amino acids of a naturally occurring polypeptide lectin.
  • the multifunctional molecule comprises a carbohydrate-binding domain of a naturally occurring lectin, i.e., a portion of a lectin that can bind to a carbohydrate in the absence of the remainder of the lectin.
  • the lectin may be non-naturally occurring, e.g. identified from an artificial library of molecules or designed by modifying the structure of a naturally occurring lectin.
  • hemagglutinins bind to carbohydrates on erythrocytes, e.g. blood group antigens, and when incubated with these cells cause them to aggregate.
  • the influenza virus hemagglutinin for example, binds to sialic acid.
  • the hemagglutinin is of a subtype from a virus that infects humans, e.g. H1, H2, or H3. In another embodiment, the hemagglutinin is of a subtype from a virus that does not infect humans, e.g. one of H4 through H15.
  • Amino acid sequences can vary up to about 20% for influenza hemagglutinins within a given subtype, and can vary between about 30% and about 70% for influenza hemagglutinins from different subtypes. Methods for determining amino acid sequence homology are known to those of skill in the art.
  • Examples of other software that can perform sequence comparisons to determine the % identity between hemagglutanin variants (or variants of any portion of the multifunctional molecules disclosed herein) include, but are not limited to, the BLAST package (Ausubel et al., 1995 , Short Protocols in Molecular Biology, 3rd Edition, John Wiley & Sons), FASTA (Atschul et al., 1990, J. Mol. Biol., 403-410) and the GENEWORKS suite of comparison tools. Both BLAST and FASTA are available for offline and online searching.
  • a scaled similarity score matrix is generally used that assigns scores to each pairwise comparison based on chemical similarity or evolutionary distance.
  • An example of such a matrix commonly used is the BLOSUM62 matrix the default matrix for the BLAST suite of programs.
  • GCG Wisconsin programs generally use either the public default values or a custom symbol comparison table if supplied. It is preferred to use the public default values for the GCG package, or in the case of other software, the default matrix, such as BLOSUM62.
  • the BLAST algorithm is employed, with parameters set to default values.
  • the BLAST algorithm is described in detail in Altschul et al., (1990) J. Mol. Biol. 215:403-410, which is incorporated herein by reference.
  • the search parameters are defined as follows, and can be advantageously set to the defined default parameters.
  • substantially identical when assessed by BLAST equates to sequences which match with an EXPECT value of at least about 7, preferably at least about 9 and most preferably 10 or more.
  • the default threshold for EXPECT in BLAST searching is usually 10.
  • BLAST Basic Local Alignment Search Tool
  • blastp, blastn, blastx, tblastn, and tblastx these programs ascribe significance to their findings using the statistical methods of Karlin and Altschul (Karlin and Altschul 1990 , Proc. Natl. Acad. Sci. USA 87:2264-68; Karlin and Altschul, 1993 , Proc. Natl. Acad. Sci. USA 90:5873-7) with a few enhancements.
  • the BLAST programs are tailored for sequence similarity searching, for example to identify homologues to a query sequence. For a discussion of basic issues in similarity searching of sequence databases, see Altschul et al (1994) Nature Genetics 6:119-129.
  • blastp compares an amino acid query sequence against a protein sequence database
  • blastn compares a nucleotide query sequence against a nucleotide sequence database
  • blastx compares the six-frame conceptual translation products of a nucleotide query sequence (both strands) against a protein sequence database
  • tblastn compares a protein query sequence against a nucleotide sequence database dynamically translated in all six reading frames (both strands);
  • tblastx compares the six-frame translations of a nucleotide query sequence against the six-frame translations of a nucleotide sequence database.
  • BLAST uses the following search parameters:
  • HISTOGRAM Display a histogram of scores for each search; default is yes. (See parameter H in the BLAST Manual).
  • DESCRIPTIONS Restricts the number of short descriptions of matching sequences reported to the number specified; default limit is 100 descriptions. (See parameter V in the manual page).
  • EXPECT The statistical significance threshold for reporting matches against database sequences; the default value is 10, such that 10 matches are expected to be found merely by chance, according to the stochastic model of Karlin and Altschul (1990). If the statistical significance ascribed to a match is greater than the EXPECT threshold, the match will not be reported. Lower EXPECT thresholds are more stringent, leading to fewer chance matches being reported. Fractional values are acceptable. (See parameter E in the BLAST Manual).
  • CUTOFF Cutoff score for reporting high-scoring segment pairs. The default value is calculated from the EXPECT value (see above). HSPs are reported for a database sequence only if the statistical significance ascribed to them is at least as high as would be ascribed to a lone HSP having a score equal to the CUTOFF value. Higher CUTOFF values are more stringent, leading to fewer chance matches being reported. (See parameter S in the BLAST Manual). Typically, significance thresholds can be more intuitively managed using EXPECT.
  • ALIGNMENTS Restricts database sequences to the number specified for which high-scoring segment pairs (HSPs) are reported; the default limit is 50. If more database sequences than this happen to satisfy the statistical significance threshold for reporting (see EXPECT and CUTOFF below), only the matches ascribed the greatest statistical significance are reported. (See parameter B in the BLAST Manual).
  • MATRIX Specific Alternate an alternate scoring matrix for BLASTP, BLASTX, TBLASTN and TBLASTX.
  • the default matrix is BLOSUM62 (Henikoff & Henikoff, 1992).
  • the valid alternative choices include: PAM40, PAM120, PAM250 and IDENTITY.
  • No alternate scoring matrices are available for BLASTN; specifying the MATRIX directive in BLASTN requests returns an error response.
  • STRAND Restrict a TBLASTN search to just the top or bottom strand of the database sequences; or restrict a BLASTN, BLASTX or TBLASTX search to just reading frames on the top or bottom strand of the query sequence.
  • FILTER Melk off segments of the query sequence that have low compositional complexity, as determined by the SEG program of Wootton & Federhen (1993) Computers and Chemistry 17:149-163, or segments consisting of short-periodicity internal repeats, as determined by the XNU program of Clayerie & States (1993) Computers and Chemistry 17:191-201, or, for BLASTN, by the DUST program of Tatusov and Lipman (NIH). Filtering can eliminate statistically significant but biologically uninteresting reports from the blast output (e.g., hits against common acidic-, basic- or proline-rich regions), leaving the more biologically interesting regions of the query sequence available for specific matching against database sequences.
  • Low complexity sequence found by a filter program is substituted using the letter “N” in nucleotide sequence (e.g., “NNNNNNNNNNN”) and the letter “X” in protein sequences (e.g., “XXXXXXXXX”).
  • Filtering is only applied to the query sequence (or its translation products), not to database sequences. Default filtering is DUST for BLASTN, SEG for other programs.
  • NCBI-gi Causes NCBI gi identifiers to be shown in the output, in addition to the accession and/or locus name.
  • sequence comparisons are conducted using the simple BLAST search algorithm provided by the NIH.
  • no gap penalties are used when determining sequence identity.
  • Influenza hemagglutinin is expressed as a single polypeptide chain, designated HA0, which trimerizes post-translationally.
  • HA0 is proteolytically cleaved to yield two domains, HA1 and HA2, which are disulfide-bonded to each other.
  • HA1 comprises significant sialic acid binding activity, while HA2 is anchored to the viral membrane and facilitates fusion of this membrane with a host cell membrane.
  • multifunctional molecule comprising first and second parts comprises an amino acid sequence of an HA1 domain.
  • lectin molecules useful in the present invention include, but are not limited to, those lectins shown in Table 1, and variants thereof having at least 50%, 70%, 90%, and up to 99% sequence homology with the sequences of the lectins shown in Table 1.
  • TABLE 1 KEY NAME ABBREVIATION CLASS LECTIN CODE [1] /../. Quail Intestinal — LECa.Ggg.Sss.xx.Xxxx. Lectin. [2] /../. Porcine Heart Lectin — LECa.Ggg.Sss.xx.Xxxx. (PHL). [3] /../.
  • Amaranthus Amaranthin LECp.Ama.Cru.se.Hga1. cruentus . group.
  • Amaranthus AHML Amaranthin. Amaranthin LECp.Ama.Hyp.xx.Xgal1. hypochondriacus . group.
  • Amaranthus Amaranthin LECp.Ama.Leu.se.Hga1. leucocarpus . group.
  • Amphicarpaea ABrA Legume lectins.
  • lectins are classed (PNA) as legume lectins.
  • LECp.Ara.Hyp.no.Hga1 GNL
  • LECp.Ara.Hyp.se.Hga1 MNL
  • LECp.Ara.Hyp.se.Hga1 PRA-I
  • Araucaria Lectin I, Lectin II. LECp.Ara.Bra.se.Hmg1 brasiliensis . (Lectin I) LECp.Ara.Bra.se.Hmg2 (Lectin II).
  • Arion — LECi.Ari.Emp.xx.Xxxx. empiricorum .
  • Arisaema ACA. LECp.Ari.Con.tu.Hcu1. consanguineum .
  • Arisaema ACmA. LECz.Ari.Cur.tu.Hcu1. curvatum .
  • Arthrobotrys AOL. LECf.Art.Oli.xx.Xxxx. oligospora .
  • Ascaris — — LECi.Asc.Lum.xx.Xxxx. lumbricoides .
  • Asparagus — — LECp.Asp.Off.xx.Xxxx. officinalis .
  • Bacillus — — LECb.Bac.Pols.xx.Xxxx. polymyxa .
  • Bacterioides — — LECb.Bac.Fra.xx.Xxxx. fragilis .
  • Bos Taurus Mannose 6-phosphate P-lectin. LECa.Bos.Tau.xx.Xxxx. receptor (1C39).
  • Bos taurus Bovine Conglutinin. C-lectin or LECa.Bos.Tau.xx.Xxxx. Collectin.
  • Bos taurus Bovine collectin-43 C-lectin or Leca.Bos.Tau.xx.Xxxx. (CL-43). Collectin.
  • Botryllus S-lectin. LECi.Bot.Sch.xx.Xxxx. scheri .
  • Botrytis cinerea . — — LECz.Bot.Cin.xx.Xxxx.
  • campetsris [99] Brassica — — LECp.Bra.Nap.xx.Xxxx. napobrassica . [100] Brassica napus . — — LECp.Bra.Nap.xx.Xxxx. [101] Bryonia dioica . BDA. — LECp.Bry.Dio.tu.Hga1. [113] Cancer — — LECi.Can.Ant.xx.Xsi1. antennarius . [114] Candida albican Adhesins. — LECf.Can.Alb.xx.Xfu1. adhesin. [115] Canna generalis .
  • Capnocytophaga LECu.Cap.Gin.xx.Xxxx. gingivalis Actinomyces Israelii Coaggregation agglutinin.
  • Caragana CAA-I, CAA-II. LECp.Car.Arb.se.Hga1 arborescens . (CAA-I) LECp.Car.Arb.se.Hga2 (CAA-II).
  • Cicer arietinum . CAA. LECp.Cic.Ari.se.Hcu1.
  • Cinachyrella LECi.Cin.All.xx.Xxxx. alloclada .
  • Cinnamonum LECp.Cin.Cam.xx.Xxxx. camphora .
  • Citrullus vulgaris . — — LECp.Cit.Vul.xx.Xxxx.
  • Clerodendron CTA. LECp.Cle.Tri.fr.Hga1. trichotomum .
  • Clitocyba — LECf.Cli.Neb.xx.Xxxx. nebularis .
  • Cucumaria CEL-III. LECi.Cuc.Ech.xx.Xxxx. echinata .
  • CMA-I LECp.Cyt.Mul.se.Hfu1
  • Cytisus scoparius CSA-I, CSA-II, — LECp.Cyt.Sco.se.Hga1 CMH-I, CMH-II.
  • CS-I LECp.Cyt.Sco.se.Hga2
  • CSA-I LECp.Cyt.Ses.se.Hga1
  • Dacrymycetales .
  • Echinocereus LECp.Echi.Eng.xx.Xxxx. engelmanii .
  • Echis EMS16. LECi.Ech.Mul.xx.Xxxx. multisquamatus .
  • Electrophorus Electrolectin. LECi.Ele.Ele.xx.Xxxx. electricus .
  • Elymus Hevein domain LECp.Ely.Can.se.Hch1. canadensis . lectin, chitin binding.
  • Escherichia coli Pili mannose-specific Verotoxin-1: LECb.Ech.Col.xx.Xxxx. FimH adhesin ADP-ribosylating (1QUN),. toxins.
  • Euhadra — LECz.Euh.Cal.xx.Xxxx. callizoma .
  • Euphorbia LECp.Eup.Sss.xx.Xxxx. characias .
  • Euphorbia LECp.Eup.Het.xx.Xga1. heterophylla .
  • Evonymus — LECp.Evo.Eur.se.Hcu1.
  • Galanthus nivalis . Monocot lectin. LECp.Gal.Niv.bu.Hma1.
  • Gallus gallus . Chicken Hepatic — LECa.Gal.Gal.xx.Xxxx. lectins (CHL).
  • Gallus gallus . Chicken egg — LECa.Gal.Gal.xx.Xxxx. agglutinins.
  • Gallus gallus Chicken Serum C-lectin or LECa.Gal.Gal.xx.Xxxx. Mannose-Binding Collectin. Protein.
  • Gallus gallus Chicken Liver C-lectin or LECa.Gal.Gal.xx.Xxxx. Mannose-Binding Collectin. Protein.
  • Gallus gallus Chicken Thymic S-lectin or GLTa.Gal.Gal..xx.Xxxx. Electrolectin (CTE). Galectin. [247] Gallus gallus .
  • Haynaldia villosa Hevein domain LECp.Hay.Vil.se.Hch1. lectin, chitin binding.
  • Helianthus annus . beta-prism plant LECp.Hel.Ann.xx.Xxxx. lectin.
  • Helianthus HTA Jacalin-related LECp.Hel.Tub.tu.Hmmm1. tuberosus . lectins.
  • Helicobacter HP-SAL. LECb.Hel.Pyl.xx.Xxxx. pylori .
  • Helix aspersa .
  • Lectins (HKML, HCCML). [289] Homo sapiens . Human Synovial — LECh.Hom.Sap.xx.Xxxx. Tissue Lectins. [290] Homo sapiens . Human Placenta — LECh.Hom.Sap.xx.Xxxx. Lectins (HPL-H, HPL-BG). [291] Homo sapiens . Human Brain — LECh.Hom.Sap.xx.Xxxx. Galactoside-binding Lectin. [292] Homo sapiens . Human 14-kDa — LECh.Hom.Sap.xx.Xxxx. Lectins.
  • Homo sapiens Human Core-specific — LECh.Hom.Sap.xx.Xxxx. Lectin (HCSL).
  • Homo sapiens Cell Membrane — LECh.Hom.Sap.xx.Xxxx. Lectins.
  • Homo sapiens Tumoricidal — LECh.Hom.Sap.xx.Xga1. Macrophage Lectin.
  • Tumor-associated LECa.Ggg.Sss.xx.Xxxx. Vertebrate Lectin.
  • Homo sapiens .
  • Homo sapiens Human Dendritic — LECh.Hom.Sap.xx.Xxxx. Cell Immunoreceptor (DCIR).
  • DCIR Cell Immunoreceptor
  • Homo sapiens Human Seminal — LECh.Hom.Sap.xx.Xxxx. Lectin (HSL).
  • Homo sapiens Charcot-Leyden S-lectin or GLTh.Hom.Sap.xx.Xxxx. crystal protein Galectin. (1LCL).
  • Homo sapiens Galectin II L-14-II Proto S-lectin or GLTh.Hom.Sap.xx.Xxxx. (1HLC). Galectin.
  • Homo sapiens Human Lung C-lectin or GLTh.Hom.Sap.xx.Xxxx. Surfactant Protein Collectin. (1B08).
  • Homo sapiens Galectin III. Chimera S-lectin GLTh.Hom.Sap.xx.Xxxx. or Galectin.
  • Homo sapiens Galectin VII, hGal-7. Proto S-lectin or GLTh.Hom.Sap.xx.Xxxx. Galectin.
  • Homo sapiens Pentraxin(1CRV). Pentraxin, S- GLTh.Hom.Sap.xx.Xxxx.
  • Alpha-3/Beta-1 Integrin A (or I) INTh.Xxx.Xxx.xx.Xxxx. integrin. domain. [323] Homo sapiens . Alpha-4/Beta-1 Integrin A (or I) INTh.Xxx.Xxx.xx.Xxxx. integrin. domain. [338] Homo sapiens . Alpha-5/Beta-8 Integrin A (or I) INTh.Hom.Sap.xx.Xxxx. integrin. domain. [339] Homo sapiens . Alpha-4/Beta-7 Integrin. INTh.Hom.Sap.xx.Xxxx. Integrin. [340] Homo sapiens . Alpha-E/Beta-7.
  • Integrin. INTh.Hom.Sap.xx.Xxxx. Homo sapiens . Mucosal addressin Addressin. LECh.Xxx.Xxx.xx.Xxxx. cell adhesion molecule-1 (MADCAM-1).
  • Homo sapiens . Vascular Adhesion — LECh.Xxx.Xxx.xx.Xxxx. Molecule (VCAM-1.
  • Homo sapiens P-Selectin. Selectin. SELh.Xxx.Xxx.xx.Xxxx. [344] Homo sapiens . Intercellular Addressin?. LECh.Xxx.Xxx.xx.Xxxx.
  • Adhesion Molecule (ICAM-1, ICAM-2). [345] Homo sapiens . Peripheral Lymph Addressin. LECh.Xxx.Xxx.xx.Xxxx. Node Addressin (PNAd). [346] Homo sapiens . Vascular Adhesion — LECh.Xxx.Xxx.xx.Xxxx. Protein (VAP-1). [347] Homo sapiens . LFA-3. Addressin?. LECh.Xxx.Xxx.xx.Xxxx. [348] Homo sapiens . Versican. Soluble C-lectin LECh.Xxx.Xxx.xx.Xxxx. (‘Lecticans’). [349] Homo sapiens .
  • ACAM Adhesion Molecule
  • E-cadherin. CDHh.Hom.Sap.xx.XxxE.
  • Homo sapiens . N-cadherin CDHh.Hom.Sap.xx.XxxN. (uvomorulin).
  • Homo sapiens . VE-cadherin CDHh.Hom.Sap.xx.XxxVE. (Vascular Endothelial Cadherin).
  • Homo sapiens . P-cadherin. CDHh.Hom.Sap.xx.XxxP.
  • Annexin XI (CAP- — ANNh.Hom.Sap.xx.Xxx9. 50).
  • Homo sapiens . Endothelial Cell- CDHh.Hom.Sapxxx. Selective Adhesion Molecule (ESAM).
  • Homo sapiens . ELAM-1. CDHh.Xxx.Xxx.xx.Xxxx.
  • Homo sapiens . GMP-140. CDHh.Xxx.Xxx.xx.Xxxx.
  • Homo sapiens . Lymphocyte LECh.Xxx.Xxx.xx.Xxxx. Function-Associated Antigen-1 (LFA-1).
  • Homo sapiens . Very Late Antigen 4 LECh.Xxx.Xxx.xx.Xxxx. (VLA-4).
  • Hordeum vulgare . HVA. LECp.Hor.Vul.se.Hch1.
  • Hygrophorus LECf.Hyg.Hyp.xx.Xxxx. hypothejus .
  • Hypnea LECu.Hyp.Cer.xx.Xxxx. cervicornis .
  • Hyptos LECz.Hyp.Sua.xx.Xxxx. suaveolens .
  • Iberis amara .
  • Influenza virus Hemagglutinin. Hemagglutinin. LECv.Inf.Vir.xx.Xxxx.
  • Laccaria — — LECz.Lac.Ame.xx.Xxxx. amethystina .
  • Lachesis huta . BML. LECi.Lac.Jut.xx.Xxxx.
  • Lactarius LDL. LECf.Lac.Del.xx.Xgal1. deliciosus .
  • Lactarius — — LECz.Lac.Lig.xx.Xxxx. lignyotus .
  • Lactuca scariole PLA-I, PLA-II. — LECa.Lac.Sca.xx.Xxxx.
  • Laelia autumnalis .
  • Laetiporus PSL. LECf.Lae.Sul.xx.Xxxx. sulfureus .
  • LcLI, LcLII. LECp.Lat.Cic.xx.Xxxx.
  • Lathyrus ochrus . LOL-I, LOL-II. Legume lectin. LECp.Lat.Och.xx.Xxxx. [398] Lathyrus odoratus .
  • Leptonychotes — — LECz.Lep.Wed.xx.Xxxx. weddelli .
  • Leptospermum LAA LECp.Lep.Arc.xx.Xxxx. archinoides .
  • Leucojum . — — LECz.Leu.sss.xx.Xxxx.
  • Leucojum LAA Monocot LECp.Leu.Aes.bu.Hma1. aestivum . mannose-binding lectins.
  • Lonchocarpus Legume lectin. LECp.Lon.Cap.se.Hga1. capassa .
  • Lontonis bainesii . Legum lectins. LECp.Lon.Bai.se.Hga1 LECp.Lon.Bai.ro.Hga1.
  • Lophocereus LECp.Lop.Sho.xx.Xxxx. shotti .
  • Lotus LTA Legume lectins. LECp.Lot.Tet.se.Hfu1. tetragonolobus .
  • Phaseolus PCA Legume lectin. LECp.Pha.Coc.se.Hcu1 coccineus .
  • PCA LECp.Pha.Coc.se.Hcu2.
  • Phaseolus — LECp.Pha.Coc.xx.Xxxx. coccineus .
  • Phaseolus PLA LBA, LBL. Legume lectins. LECp.Pha.Lim.se.Hga1. limenesis .
  • Phaseolus GN1L, GNpL, GNsL. LECp.Pha.Vul.xx.Xxxx. vulgaris .
  • Phaseolus Pinto III. LECa.Pha.Vul.xx.Xxxx. vulgaris .
  • Phaseolus — LECp.Pha.Vul.xx.Xxxx. vulgaris .
  • Phaseolus — LECp.Pha.Vul.xx.Xxxx. vulgaris .
  • Phaseolus — LECp.Pha.Vul.xx.Xxxx. vulgaris .
  • Phaseolus — LECp.Pha.Vul.xx.Xxxx. vulgaris .
  • Phlomis — LECz.Phl.Fru.xx.Xxxx. fructicosa .
  • Plecoglossus PAL. LECa.Ple.Alt.xx.Xxxx. altivelis .
  • Pleurocybella LECf.Ggg.Sss.xx.Xxxx. porrigens .
  • Pleurotus LECf.Ple.Ost.xx.Xxxx. ostreatus .
  • Plumaria elegans . — — LECu.Plu.Ele.xx.Xxxx.
  • Polyandrocarpa C-lectin. LECi.Pol.Mis.xx.Xga1. misakiensis .
  • Polyomavirus . 1VPN. LECV.Pol.Vir.xx.Xxxx.
  • Polyporus — LECf.Pol.Fom.xx.Xxxx. fomentarius .
  • potamios [545] Prunus Americana . — — LECp.Pru.Ame.xx.Xxxx. [546] Prunus avium . — — LECp.Pru.Avi.xx.Xxxx. [547] Psathyrostachys — Hevein domain LECp.Psa.Jun.se.Hch1. juncea . lectin, chitin binding. [548] Pseudomonas — — LECb.Pse.Aer.xx.Xga1. aeruginosa .
  • Psophocarpus PTL-I WBA-I
  • PTL-II WBA-II
  • PTL-II WBA-II
  • PTL-I WBTL
  • Ratus ratus — — LECp.Rap.Sat.xx.Xxxx.
  • Ratus norvegicus Mannan Binding C-lectin or LECa.Rat.Nor.xx.Xxxx. Protein (MBP-A). Collectin.
  • Ratus ratus Rat peritioneal — LECa.Rat.Rat.xx.Xfu1 macrophage lectin. LECa.Rat.Rat.xx.Xga1.
  • Ratus ratus Galectin II.
  • Tricholoma LECf.Tri.Mon.xx.Xxxx. mongolicum .
  • Tricholomataceae — LECf.Tri.Sss.xx.Xxxx. 93-138.
  • Tricholomataceae — LECz.Tri.Sss.xx.Xxxx. 93-34.
  • Trichosanthes TJA-II, TJA-I, TK-I, — LECp.Tri.Jap.xx.Xxxx. japonica . TK-II.
  • Trifolium repens . — — LECp.Tri.Rep.xx.Xxxx.
  • Vibrio — LECb.Vib.Alg.xx.Xch1. alginolyticus .
  • Vicia graminea . VGA. LECp.Vic.Gra.xx.Xxxx.
  • Vicia unijuga . VUA. LECp.Vic.Unj.xx.Xxxx.
  • MBL-I, MBL-II. LECp.Vig.Rad.xx.Xxxx.
  • Vigna unguiculata . — — LECp.Vig.Ung.xx.Xxxx.
  • LECp.Vis.Alb.pl.Cga2 (ML-II, viscumin)
  • LECp.Vis.Alb.pl.Cga3 ML-III, VAA-II
  • LECp.Vis.Alb.pl.Hch1 (VisAlbCBA).
  • Volvariella VVL. LECf.Vol.Vol.xx.Xxxx. volvacea .
  • Wistaria WFA. LECp.Wis.Flo.xx.Xxxx. floribunda .
  • Xeromus — LECz.Xer.Chr.xx.Xxxx. chrysenteron .
  • Xylaria — LECf.Xyl.Pol.xx.Xxxx. polymorpha.
  • Zea mays .
  • Cannabis sativa . CSA. LECp.CanSat.se.Glu.
  • Smilax glabra Sarparilla. — LECp.SmiGla.rh.xxx.
  • Trichosanthes Snake gourd. anguina .
  • Lectin codes take the following form: LLLx.Ggg.Sss.ti.TspN An explanation of each index variable follows.
  • LLL refers to the general category of agglutinin. At this point six general categories are recognized: lectins (LEC), integrins (INT), cadherins (CDH), annexins (ANN), selectins (SEL) and galectins (GLT).
  • the x value refers to the taxonomic groups of the agglutinin, Table 1 summarizes these categories: Category Taxonomic group LECa, GLTa Lectin or galectin from higher animal, typically vertebrates. LECh, GLTh Lectin or galectin from humans LECi, GLTi Lectin or galectin from invertebrates LECp. Plant lectins LECf. Lectin from fungi LECu. Lectin from unicellular organisms LECb. Lectin from Bacteria LECv. Viral lectins
  • ti refers to the tissue from which the lectin has been isolated.
  • Table 2 summarizes the indices used for the various tissues: Tissue, Taxonomic cell or organ grouping Index Bark Plant Ba Bulb Plant Bu Cell membrane Bacteria, Unicellular Cm Epidermis Human, vertebrates Ep Fruit Plant Fr Hemolymph Invertebrates He Latex Plant La Leaf Plant Le Nodule Plant No Organ or cell type Human, vertebrates, Oc Invertebrates Phloem sap Plant Ps Rhizome Plant Rh Root Plant Ro Seed Plant Se Serum or plasma Human, vertebrates, Sr Invertebrates Spores or fruiting bodies Fungi Sp Stem Plant St Tentacles Invertebrates Te Tuber Plant Tu Whole body homogenate Invertebrates Wb Venom Invertebrates Ve Undefined Human, vertebrates, Un Invertebrates, Bacteria, Unicellular, Virus, Fungal
  • sp refers to the specificity group. Each group is indicated by the index given in Table 3: Specificity Index of group Mannose-binding lectins ma Mannose/maltose-binding mm lectins Mannose/glucose-binding mg lectins GlcNAc/(GlcNAc)-binding ch lectins Gal/GalNAc-binding lectins ga Fucose-binding lectins fu Sialic acid-binding lectins si Lectins with a complex but co known specificity Lectins with a complex and cu unknown specificity Lectins with a dual du specificity Lectins with an undetermined nd specificity
  • a multifunctional molecule of the invention can also be a molecule that comprises a first part which comprises a lipid and a second part which comprises an amino acid sequence which can bind to a cell surface molecule, e.g. a cell surface molecule of an APC.
  • a lipid e.g. a long-chain fatty acid
  • a polypeptide can permit the complex to become stably associated with the plasma membrane when the complex is admixed with a cell (Nagarajan et al, 1995, J Immunol Methods 184:241-51; McHugh et al, 1995, PNAS 92:8059-63; van den Berg et al, 1995, J Cell Biol, 131:669-77). This is believed to occur through intercalation of the lipid into the membrane.
  • a convenient method of producing a lipid-associated polypeptide comprises expressing, in a suitable host cell, a nucleic acid encoding, in part, a signal sequence directing the post-translational addition of a GPI moiety.
  • a naturally non-GPI linked protein can be expressed as a GPI-linked protein by constructing a nucleic acid that encodes the protein linked to a heterologous GPI signal sequence.
  • Nucleotide sequences encoding GPI signal sequences useful for this purpose include, for example, those comprised by decay accelerating factor (e.g., sequences encoding amino acid sequence “22” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32; sequences encoding signal sequences disclosed in Caras et al, U.S. Pat. No.
  • brevican e.g., nt 1982-2047 of Genbank accession number X86406
  • mesothelin e.g., nt 1858-1983 of Genbank U40434
  • coccidioides immitis antigen 2 e.g., sequences encoding amino acids 172-194 of NCBI Entrez protein database accession #1256444, Zhu et al, 1996, Gene 181:121-5
  • acetylcholinesterase e.g., sequences encoding the peptide “HC” as described in Duval et al, 1992, EMBO J.
  • T-cadherin e.g., sequences encoding the 76 C-terminal amino acids of chick T cadherin as described by Koller and Ranscht, 1996, J Biol Chem 271:30061-7
  • aminopeptidase P e.g., sequences encoding amino acids 649-673 of NCBI Entrez protein database accession #1517942, Hyde et al, 1996, Biochem J 319:197-201
  • carboxypeptidase M, CD16B, Thy 1, carbonic anhydrase IV e.g., sequences encoding amino acids 284-312 of NCBI Entrez protein database accession #179791, Okuyama et al, 1995, Arch Biochem Biophys 320:315-22
  • placental alkaline phosphatase e.g., sequences encoding amino acids 498-529 of NCBI Entrez protein database accession #178464, Oda
  • discoideum prespore-specific antigen e.g., sequences encoding amino acid sequence “4” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32
  • microsomal dipeptidase e.g., sequences encoding amino acid sequence “8” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32
  • CAMPATH-1 e.g., sequences encoding amino acid sequence “9” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32
  • T T.
  • brucei PARP e.g., sequences encoding amino acid sequence “10” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32
  • T. brucei VSG Mit 118a e.g., sequences encoding amino acid sequence “11” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32
  • T. brucei VSG Mit 117a e.g., sequences encoding amino acid sequence “12” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32
  • brucei VSG MITat 1.1000 BC (e.g., sequences encoding amino acid sequence “13” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG MITat 1.5b (e.g., sequences encoding amino acid sequence “14” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG ILTat 1.1 (e.g., sequences encoding amino acid sequence “15” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T.
  • brucei VSG TxTat 1 (e.g., sequences encoding amino acid sequence “16” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG Mit 221 (e.g., sequences encoding amino acid sequence “17” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), prion proteins (e.g., sequences encoding amino acid sequence “18” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), urokinase receptor (e.g., sequences encoding amino acid sequence “21” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T.
  • TxTat 1 e.g., sequences encoding amino acid sequence “16” in Table
  • congolense VSG YNat 1.1 (e.g., sequences encoding amino acid sequence “23” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), S. cerevesiae GAS-1 (e.g., sequences encoding amino acid sequence “24” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), Thy-1 (e.g., sequences encoding amino acid sequences “25” or “26” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), L.
  • S. cerevesiae GAS-1 e.g., sequences encoding amino acid sequence “24” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32
  • Thy-1 e.g., sequences encoding amino acid
  • GPI-linked polypeptides can be extracted from cells using the following method. 5 ⁇ 10 6 cells are spun down and frozen at ⁇ 80° C. The pellet is thawed in 14 ml of 0.15M NaCl/10 mM Tris 7.4/0.1 mM primaquine/2% Trito X-114 with stirring at 0° C. for 1 h, then centrifuged at 8800 g at 0° C. for 10 min. The supernatant is maintained at ⁇ 20° C. overnight, thawed at room temperature, and then placed at 32° C. for 12 min. It is then centrifuged at 3000 g for 3 min at 32° C.
  • the top layer is decanted and 11 ml of cold Buffer A (0.15M NaCl/10 mM Tris 7.4/0.1 mM primaquine/0.06% Triton X-114) is added to the bottom layer. This is incubated on ice for 10 min. The 12 min 32° C. incubation 32° C. 30002 centrifugation, decanting of top layer, and addition of 11 ml cold Buffer A to bottom layer are repeated. The solution is centrifuged at 18000 g for 10 min at 0° C. The 12 min 32° C. incubation, 32° C. 3000 g centrifugation, and decanting of top layer are repeated. 3 vol of cold acetone are added to the final bottom phase.
  • cold Buffer A (0.15M NaCl/10 mM Tris 7.4/0.1 mM primaquine/0.06% Triton X-114
  • the solution is centrifuged at 12, 000 RPM for 30 min, the supernatant removed, and the protein pellet containing the GPI fraction dried under vacuum.
  • Specific proteins can be purified by methods well-known to those skilled in the art, e.g. immunoaffinity purification.
  • Another method of producing a lipid-linked polypeptide is to chemically link the polypeptide to a fatty acid such as palmitate.
  • 1.5 mg/ml of the polypeptide is suspended in PBS, pH 7.8, containing 0.3% deeoxycholic acid, 0.1% sodium bicarbonate, and 0.1% sodium azide.
  • the optimal final pH of the solution is 7.6-8.0.
  • the mixture is warmed to 37° C. and the N-hydroxysuccinimide ester of palmitic acid (Research Organics, Cleveland, Ohio) is added to a final concentration of 0.1 mg/ml.
  • the solution is incubated overnight at room temperature.
  • the polypeptide is purified by passage through a 16 ⁇ 250 mm Sephadex G-75 chromatography column equilibrated with 0.15% deoxycholic acid in PBS, pH 7.6.
  • crosslinking agent is a chemical entity that can react with functional groups on at least two other molecules, e.g. two polypeptides or a polypeptide and a lipid, such that upon reaction with the crosslinking agent the two molecules become covalently linked.
  • a ligand for CD40 can be crosslinked to a molecule on the surface of a cell.
  • crosslinking agents both bifunctional and polyfunctional, are known in the art and are commercially available, e.g. from Sigma (St. Louis, Mo.). These include, for example, S-acetylmercaptosuccinic anhydride, 5-acetylthioglycolic acid N-hydroxysuccinimide ester, S-acetylthiopropionic acid N-hydroxysuccinimide ester, adipic acid dihydrazide, 4-azidobenzoic acid N-hydroxysuccinimide ester, N-(5-azido-2-nitrobenzyloxy)succinimide, 6-(4-azido-2-nitrophenylamino)hexanoic acid N-hydroxysuccinimide ester, p-azidophenacyl bromide, N-(4-azidophenylthio)phthalimide, 4-azidosalicylic acid N-hydroxysuccinimide ester, bromo
  • the multifunctional molecules of the present invention comprise one part which is a lectin and is capable of binding to at least one carbohydrate molecule on an antigen bearing target, and a second part comprising a ligand for a cell surface protein of an antigen presenting cell.
  • the ligand can be any ligand which binds to one or more of the cell surface molecules indicated by GenBank Accession number in Appendix I or II. More preferably, however, the ligand includes, but is not limited to an opsonin, a cytokine, a heat shock protein, an adhesion molecule.
  • a defensin, or a counterreceptor for a T cell costimulatory molecule or a portion of any of these molecules, e.g., about (or at least about) 5, 8, 10, 12, 15, 20, 25, 35, 40, 50, 60, 70, 80, 100, or 120 contiguous amino acid residues, up to the full length of such a molecule.
  • cytokine refers to a polypeptide molecule that is naturally secreted by mammalian cells and that binds to a cell surface receptor on a leukocyte.
  • cytokine also refers herein to a polypeptide molecule that is a ligand for a receptor for a naturally occurring cytokine. Unlike an opsonin, a cytokine does not naturally contemporaneously bind an antigen and a cell-surface receptor.
  • Leukocytes which bear receptors for cytokines include, for example, monocytes, macrophages, dendritic cells, neutrophils, eosinophils, basophils, platelets, lymphocytes, T lymphocytes, B lymphocytes, NK cells, myeloma cells, lymphoma cells, and leukemic cells.
  • cell-surface associated cytokines provide an advantage over freely diffusible cytokines by allowing stable juxtaposition of the cytokine to the cell, thus increasing the concentration of cytokine in the vicinity of the cell.
  • cytokines are non-rodent cytokines, e.g primate, e.g. human cytokines.
  • cytokines can be regarded as belonging to one or more families of cytokines based on structural and/or functional properties.
  • One such family consists of the interleukins. Interleukins are structurally diverse, but share the property of both being expressed by and acting on leukocytes. Examples of interleukins include IL-1 (e.g. polypeptides encoded by Genbank Accession No. M15330, M28983, E04743, M15131) IL-2 (e.g. polypeptides encoded by Genbank Accession No. E01108, K02797), IL-3 (e.g. polypeptides encoded by Genbank Accession No. A02046, M14743), IL-4 (e.g.
  • IL-12 e.g. polypeptides encoded by Genbank Accession No. M86671, S82412; Genbank protein P29459, P29460
  • IL-13 e.g. polypeptides encoded by U31120, L13028
  • 1L-14 e.g. sequences disclosed in Ambrus et al, Proceedings of the National Academy of Science (USA) 1993; 90: 6330-4
  • IL-15 e.g. polypeptides encoded by AF031167, U22339
  • 1L-16 e.g.
  • polypeptides encoded by AF006001, M90391) IL-17 (e.g. polypeptides encoded by U32659, U43088), IL-18 (e.g. polypeptides encoded by D49949, D49950), IL-19 (e.g. polypeptides encoded by AY040367), IL-20 (e.g. polypeptides encoded by NM02130, NM018724), IL-21 (e.g. polypeptides encoded by AF254069, AF254070), IL-22 (e.g. polypeptides encoded by AF279437), IL-23 (e.g.
  • polypeptides encoded by AF301619, AF301620, AY055379 [p19 alpha chain combines with IL-12 p40 chain to form IL-23]), IL-24 (e.g. polypeptides encoded by AF276916, NM053095), IL-25 (e.g. polypeptides encoded by NM080837), TNF-alpha (e.g. polypeptides encoded by M16441, Y00467), and GM-CSF (e.g. polypeptides encoded by X03019, M11220) and their homologues among species. Nucleotide sequences encoding homologues will hybridize to each other under moderate- to high-stringency conditions.
  • hematopoietins Another family consists of the hematopoietins. Members of this family comprise helical regions, known as helices A, B, C, and D. Helices A and B and helices C and D run roughly parallel to each other, respectively. Examples of hematopoietins include IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-11, IL-12, IL-13, IL-15, GM-CSF, G-CSF (e.g. polypeptides encoded by Genbank Accession No. E01219, M13926), oncostatin M (e.g. polypeptides encoded by Genbank Accession No.
  • Human IL2 is a protein of 133 amino acids (15.4 kDa) with a slightly basic pI.
  • Murine and human IL2 display a homology of approximately 65%.
  • IL2 is synthesized as a precursor protein of 153 amino acids with the first 20 amino-terminal amino acids functioning as a hydrophobic secretory signal sequence.
  • the protein contains a single disulfide bond (positions Cys58/105) essential for biological activity.
  • IL2 is O-glycosylated at threonine at position 3. Variants with different molecular masses and charges are due to variable glycosylation. Non-glycosylated IL2 is also biologically active. Glycosylation appears to promote elimination of the factor by hepatocytes.
  • a dimeric form of human IL2 produced by the action of a transglutaminase isolated from regenerating fish optic nerves, has been shown to be a cytotoxic factor for rat brain oligodendrocytes in culture.
  • the human IL2 gene contains four exons.
  • the IL2 gene maps to human chromosome 4q26-28 (murine chromosome 3).
  • the homology of murine and human IL2 is 72% at the nucleotide level in the coding region.
  • IL2 The biological activities of IL2 are mediated by a membrane receptor that is expressed almost exclusively on activated, but not on resting, T-cells at densities of 4-12 ⁇ 13 receptors/cell. Activated B-cells and resting mononuclear leukocytes rarely express this receptor.
  • the expression of the IL2 receptor is modulated by IL5 and IL6.
  • Three different types of IL2 receptors are distinguished that are expressed differentially and independently.
  • the high affinity IL2 receptor (Kdis ⁇ 10 pM) constitutes approximately 10% of all IL2 receptors expressed by a cells.
  • TAC antigen T-cell activation antigen; p55
  • IL2R-beta IL2R-beta
  • p75 is expressed constitutively on resting T-lymphocytes, NK-cells, and a number of other cell types while the expression of p55 is usually observed only after cell activation.
  • p55 is, however, synthesized constitutively by a number of tumor cells and by HTLV-1-infected cells.
  • IL2 receptor expression of monocytes is induced by IFN-gamma, so that these cells become tumor-cytotoxic.
  • T-cells the expression of p75 can be reduced by IL3.
  • p55 (e.g. polypeptides encoded by Genbank Accession No. X01057) has a length of 251 amino acids with an extracellular domain of 219 amino acids an a very short cytoplasmic domain of 13 amino acids.
  • the p55 gene maps to human chromosome 10p14-p15.
  • p75 (e.g. polypeptides encoded by Genbank Accession No. M26062, M28052) has a length of 525 amino acids with an extracellular domain of 214 amino acids and a cytoplasmic domain of 286 amino acids.
  • the p75 gene contains 10 exons and has a length of approximately 24 kb. It maps to human chromosome 22q11.2-q12 and to murine chromosome 15 (band E).
  • a third 64 kDa subunit of the IL2 receptor designated gamma
  • Murine and human gamma subunits of the receptor have approximately 70% sequence identity at the nucleotide and amino acid levels. This subunit is required for the generation of high and intermediate affinity IL2 receptors but does not bind IL2 by itself.
  • These two receptor types consist of an alpha-beta-gamma heterotrimer and a beta-gamma heterodimer, respectively.
  • the gene encoding the gamma subunit of the IL2 receptor maps to human chromosome Xq13, spans approximately 4.2 kb and contains eight exons.
  • the gamma subunit of the IL2 receptor has been shown recently to be a component of the receptors for IL4 and IL7. It is also believed to be a component of the IL13 receptor.
  • the amino acids at positions 267-317 lying directly adjacent to the transmembrane region of p75 are involved in IL2-mediated signal transduction.
  • the IL2 receptor is associated with a number of other proteins (p22, p40, p100) which are thought to be involved in mediating conformational changes in the receptor chains, receptor-mediated endocytosis, and further signal transduction processes.
  • One of the identified proteins is the 95 kDa cell adhesion molecule ICAM-1 which probably focuses IL2 receptors at regions of cell-to-cell contacts and thus may mediate paracrine activities, for example, during IL2-mediated stimulation of T-cells.
  • Another protein associated with p75 is a tyrosine-specific protein kinase called lck.
  • IL2 receptor signaling may also be mediated by vav.
  • sIL2R soluble IL2 receptor
  • concentrations of this soluble receptor vary markedly in different pathological situations, for example, infections, autoimmune diseases, leukemias, or after organ transplantation. Levels may increase up to 100-fold. The levels of sIL2R appear to correlate with the severity of HIV-induces diseases and may be of diagnostic value also in other settings.
  • Mouse and human IL2 both cause proliferation of T-cells of the homologous species at high efficiency. Human IL2 also stimulates proliferation of mouse T-cells at similar concentrations, whereas mouse IL2 stimulates human T-cells at a lower (sixfold to 170-fold) efficiency.
  • IL2 is a growth factor for all subpopulations of T-lymphocytes. It is an antigen-unspecific proliferation factor for T-cells that induces cell cycle progression in resting cells and thus allows clonal expansion of activated T-lymphocytes. This effect is modulated by hormones such as prolactin.
  • IL2 also promotes the proliferation of activated B-cells also this requires the presence of additional factors, for example, IL4.
  • IL2 Due to its effects on T-cells and B-cells IL2 is a central regulator of immune responses. It also plays a role in anti-inflammatory reactions, in hematopoiesis and in tumor surveillance. IL2 stimulates the synthesis of IFN-gamma in peripheral leukocytes and also induces the secretion of IL1, TNF-alpha and TNF-beta.
  • LAK cells lymphokine-activated killer cells
  • IL2 can be assayed in bioassays employing cell lines that respond to the factor (e.g., ATH8, CT6, CTLL-2, FDCPmix, HT-2, NKC3, TALL-103).
  • ATH8 CT6, CTLL-2, FDCPmix, HT-2, NKC3, TALL-103 Specific ELISA assays for IL2 and enzyme immunoassays for the soluble receptor are also available.
  • the soluble receptor can be detected also by employing biotinylated IL2 and flow-through cytometry or ELISA assays.
  • IL2 displays significant anti-tumor activity for a variety of tumor cell types since it supports the proliferation and clonal expansion of T-cells that specifically attack certain tumors.
  • IL2 is increasingly used to treat patients with cancers refractory to conventional treatment.
  • Combination therapy with systemically administered IL2 has resulted in long-term remissions in 30% of patients with metastatic renal cell carcinoma, for which there is no standard treatment.
  • Objective and long-lived clinical responses have been documented also in a proportion of patients with melanoma or acute myeloid leukemia.
  • IL2 has additional effects on other components of the cellular immune system, including B-cells and macrophages, and induces the secretion of other soluble mediators, including TNF-alpha, TNF-beta, and IFN-gamma. These effects may contribute to the antitumor activity of IL2 as well as to its dose-related toxicity.
  • the transduction of murine tumor cells with a functional IL2 gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts. Altered tumor cells expressing IL2 also increase systemic immunity.
  • Human IL4 is a protein of 129 amino acids (20 kDa) that is synthesized as a precursor containing a hydrophobic secretory signal sequence of 24 amino acids. IL4 is glycosylated at two arginine residues (positions 38 and 105) and contains six cysteine residues involved in disulfide bond formation. The disulfide bonds are essential for biological activity. Some glycosylation variants of IL4 have been described that differ in their biological activities. A comparison of murine and human IL4 shows that both proteins only diverge at positions 91-128.
  • Y124D also acts as a powerful antagonist for the IL13 receptor.
  • the human IL4 gene contains four exons and has a length of approximately 10 kb. It maps to chromosome 5q23-31. The murine gene maps to chromosome 11. The IL4 gene is in close proximity to other genes encoding hematopoietic growth factors (e.g., GM-CSF, M-CSF, IL3, IL5). The distance between the IL4 and the IL5 gene is approximately 90-240 kb.
  • hematopoietic growth factors e.g., GM-CSF, M-CSF, IL3, IL5
  • the human and the murine IL4 gene display approximately 70% homology.
  • the 5′ region of the IL4 contains several sequence elements, designated CLE (conserved lymphokine element), that are binding sites for transcription factors controlling the expression of this and other genes.
  • a sequence motif, called P sequence (CGAAAATTTCC; SEQ ID NO: 1) in the 5′ region of the human IL4 gene (positions ⁇ 79- ⁇ 69) is the binding site for a nuclear factor, called NF(P), mediating the response to T-cell activation signals.
  • the extracellular domain of the IL4 receptor is related to the receptors for erythropoietin (Epo), IL6, and the beta chain of the IL2 receptor. It has been given the name CD124.
  • the cDNA for the murine IL4 receptor encodes a transmembrane protein of 810 amino acids (including a secretory signal sequence). This receptor has a large intracellular domain of 553 amino acids.
  • the human receptor has an extracellular domain of 207 amino acids, a transmembrane domain of 24 residues, and a large intracellular domain of 569 amino acids.
  • the IL4 receptor has been shown recently to contain the gamma subunit of the IL2 receptor as a signaling component. This gamma subunit is also associated with the receptors for IL4 and IL7 and probably also of IL13. Two forms of the receptor have been described, one of which is secreted. The secreted receptor only contains the extracellular IL4 binding domain and is capable of blocking IL4 activities.
  • An IL4 binding protein (IL4-BP) that binds IL4 with the same affinity as the IL4 receptor has been shown also to be a soluble IL4 receptor variant. These soluble receptors probably function as physiological regulators of cytokine activities by inhibiting receptor binding or act as transport proteins. Soluble receptors or binding proteins have been described also for IL1 (IL1 receptor antagonist), IL2, IL6, IL7, TNF-alpha, IGF, and IFN-gamma.
  • IL4 The biological activities of IL4 are species-specific; mouse IL4 is inactive on human cells and human IL4 is inactive on murine cells.
  • IL4 promotes the proliferation and differentiation of activated B-cells, the expression of class II MHC antigens, and of low-affinity IgE receptors in resting B-cells.
  • IL4 enhances expression of class II MHC antigens on B-cells. It can promote their capacity to respond to other B-cell stimuli and to present antigens for T-cells. This may be one way to promote the clonal expansion of specific B-cells and the immune system may thus be able to respond to very low concentrations of antigens.
  • IL4 The production of IL4 by non-B non-T-cells is stimulated if these cells interact with other cells via their Fc receptors for IgE or IgG. This effect can be enhanced by IL3.
  • IL2 and PAF platelet activating factor
  • IL3 antagonizes the IL2-induced effects in B-cells and causes a slow decrease of the expression of IL2 receptors, thus inhibiting the proliferation of human B-cells stimulated by IL2.
  • IL4 stimulates the synthesis of IgG1 and IgE and inhibits the synthesis of IgM, IgG3, IgG2a and IgG2b.
  • This isotype switching induced by IL4 in B-cells is antagonized by IFN-gamma.
  • the growth of multiple myelomas can be suppressed by IL4 which inhibits the synthesis of IL6, a myeloma growth factor.
  • IL4 also inhibits the synthesis of IL6 in human alveolar macrophages.
  • Pretreatment of macrophages with IL4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma.
  • IL4 synergises with Epo and G-CSF/Epo in the generation of colonies containing granulocytes or erythroid progenitor cells in a colony formation assay.
  • the classical detection method for IL4 is a B-cell costimulation assay measuring the enhanced proliferation of stimulated purified B-cells.
  • IL4 can be detected also in bioassays, employing IL4-responsive cells (e.g., BALM-4; BCL1; CT.4S; CTL44; CTLL-2; Da; FDCPmix; HT-2; L4; L138.8A; M07E; MC/9; NFS-60; Ramos, Sez627, TF-1; TS1).
  • a specific detection method for human IL4 is the induction of CD23 in a number of B-cell lines with CD23 detected either by flow-through cytometry or by a fluorescence immunoassay.
  • An immunoassay that allows rapid determination of the rate of IN production under conditions preventing consumption/degradation is cytokine immunotrapping.
  • IL4 inhibits the growth of colon and mammary carcinomas. It has been shown to augment the development of LAK cells. The transduction of murine tumor cells with a functional IL4 gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts. Altered tumor cells expressing IL4 also increase systemic immunity. Mice vaccinated with transduced cells reject a subsequent challenge of non-transduced cells, and, in some cases, a pre-existing tumor.
  • Human IL6 is a protein of 185 amino acids glycosylated at positions 73 and 172. It is synthesized as a precursor protein of 212 amino acids. Monocytes express at least five different molecular forms of IL6 with molecular masses of 21.5-28 kDa. They mainly differ by post-translational alterations such as glycosylation and phosphorylation.
  • IL6 isolated from various cell types shows some microheterogeneity in its N terminus. A 42-45 kDa form has been observed in plasma that is probably complexed with a carrier protein, alpha-2-macroglobulin ( ⁇ 2M). Murine and human IL6 show 65% sequence homology at the DNA level and 42% homology at the protein level.
  • IL6 is a member of a family of cytokines which also includes LIF, CNTF, Oncostatin M, IL11, and CT-1. All known members of the IL6 cytokine family induce hepatic expression of acute phase proteins.
  • the human IL6 gene has a length of approximately 5 kb and contains five exons. It maps to human chromosome 7p21-p14 between the markers D7S135 and D7S370.
  • the murine gene maps to chromosome 5.
  • the nucleotide sequences of IL6 and G-CSF genes resemble each other in a way suggesting a possible evolutionary relationship.
  • the IL6 receptor (e.g. polypeptides encoded by Genbank Accession No. M20566, E03515) is expressed on T-cells, mitogen-activated B-cells, peripheral monocytes and some macrophage- and B-cell-derived tumor cell types. It is not expressed in resting B-cells but is in resting T-cells. In hepatocytes the IL6 receptor expression is enhanced after treatment with IL6 or IL1. In several cell types the expression of the IL6 receptor is also enhanced by glucocorticoids.
  • the IL6 receptor gene maps to human chromosome 1q21.
  • the IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids. It has been designated CD126. It is synthesized as a precursor of 468 amino acids. The molecular structure resembles that of receptors for M-CSF, PDGF and IL1 in that the receptor contains an immunoglobulin-like sequence domain in the aminoterminal region of the extracellular receptor domain.
  • the intracellular domain of the IL6 receptor has a length of approximately 82 amino acids and does not show any homology to other proteins involved in intracellular signal transduction.
  • Biological activities of IL6 have been found also at concentrations of 10 ⁇ 13 -10 ⁇ 15 M suggesting either the existence of other high-affinity receptor conformations or the existence of further receptor molecules with higher affinities.
  • IL6 receptor-mediated signal transduction involves protein kinase C and also adenylate cyclase.
  • gp130 transmembrane glycoprotein
  • LIL factor A factor resembling STAT proteins, termed LIL factor, has been found to be involved in signaling pathways of IL6, and also of IL1 and bacterial lipopolysaccharides.
  • IL6R-SUP IL6 receptor soluble urinary protein
  • IL6R-SUP IL6 receptor soluble urinary protein
  • Some cells including hematopoietic progenitor cells and neuronal cells, are only responsive towards a combination of IL6 and soluble IL6 receptor but not to IL6 alone.
  • Human IL6 is biologically active in monkeys, rats, and mice.
  • Murine IL6 is not active in human cells.
  • the plethora of biological activities is exemplified by the many different acronyms under which IL6 has been described.
  • IL6 is a pleiotropic cytokine influencing antigen-specific immune responses and inflammatory reactions. It is one of the major physiological mediators of cute phase reaction.
  • IL6 in combination with glucocorticoids induces the synthesis of metallothioneins and increases intracellular zinc levels, thus preventing CCL4-induced hepatotoxicity.
  • IL6 is a neurotrophic factor for cholinergic neurons that promotes their survival in culture. Some neuronal cell lines can be induced to differentiate by IL6.
  • IL6 like IL1, stimulates the synthesis of ACTH (Corticotropin) in the pituitary. Glucocorticoids synthesized in response to ACTH inhibit the production of IL6, IL1 and TNF in vivo, thus establishing a sort of negative feedback loop between the immune system and neuroendocrine functions. In astrocytes IL6 induces the synthesis of Nerve Growth Factor (NGF).
  • NGF Nerve Growth Factor
  • IL6 is a B-cell differentiation factor in vivo and in vitro and an activation factor for T-cells. In the presence of IL2 IL6 induces the differentiation of mature and immature T-cells into cytotoxic T-cells. IL6 also induces the proliferation of thymocytes and probably plays a role in the development of thymic T-cells.
  • IL6 is capable of inducing the final maturation of B-cells into immunoglobulin-secreting plasma cells if the cells have been pre-activated by IL4.
  • IL6 stimulates the secretion of antibodies to such a degree that serum IgG1 levels can rise 120-400-fold.
  • IL6 at concentrations of only 0.002 ng/mL is one of the major autocrine growth modulator for many human myelomas.
  • the growth of these cells can be inhibited by monoclonal antibodies directed against IL6. It can be inhibited also by the introduction of antisense oligonucleotides against IL6 or by IL4.
  • the growth-inhibitory effects of corticosteroids on myeloma cells is probably due to the steroid-induced reduction in the expression of IL6.
  • the growth of human IL6 dependent myeloma cells can be inhibited also by IFN-gamma.
  • IL6 may also function as an autocrine growth modulator for other tumor types, some of which have been found to secrete IL6 constitutively. IL6 has been shown to be an autocrine modulator of growth for in vitro cervical tumor cell growth. On the other hand IL6 blocks the growth of some solid tumors such as mammary carcinomas, cervical carcinomas, human lung cancer cell lines, histiocytic lymphomas, and melanomas.
  • IL6 and IL3 synergise in vitro in promoting the proliferation of multipotent hematopoietic progenitor cells.
  • IL6 is also a thrombopoietin that induces the maturation of megakaryocytes in vitro and increases platelet counts in vivo.
  • IL6 shows activities resembling those of GM-CSF.
  • Plasmacytoma cells produce IL6 and also the IL6 receptor. It has been suggested that these cells are stimulated in an autocrine fashion. A paracrine mechanism involving the presence of two different cell populations, one producing the factor and the other expressing the receptor, has been described also.
  • IL6 can be detected in bioassays employing IL6 responsive cell lines (e.g., 7TD1; B19; CESS, KPMM2, KT-3; M1, MH60-BSF-2, M07E; Mono Mac 6; NFS-60; PIL-6; SKW6-C14; T1165; XG-1). IL6 can be assayed also by its activity as a hybridoma growth factor. Sensitive immunoassays and colorimetric tests are also available. An ELISA assay exists for detecting the receptor-associated gp130 protein.
  • IL6 responsive cell lines e.g., 7TD1; B19; CESS, KPMM2, KT-3; M1, MH60-BSF-2, M07E; Mono Mac 6; NFS-60; PIL-6; SKW6-C14; T1165; XG-1).
  • IL6 can be assayed also by its activity as a hybridoma growth factor. Sensitive immunoassay
  • IL6 may be useful in the treatment of some tumor types.
  • the transduction of murine tumor cells with a functional IL6 gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts. Altered tumor cells expressing IL6 also increase systemic immunity. Mice vaccinated with transduced cells reject a subsequent challenge of non-transduced cells, and, in some cases, a pre-existing tumor.
  • Human IL10 is a homodimeric protein with subunits having a length of 160 amino acids. Human IL10 shows 73% amino acid homology with murine IL10. The human IL10 contains four exons. It is closely related to the product of the BCRF-1 gene (Bam HI C fragment rightward reading frame) of Epstein-Barr virus (84% homology at the protein level). These two proteins are more closely related to each other than human and murine IL10. BCRF-1 has therefore also been called viral IL10 (vIL10). The human IL10 gene maps to chromosome 1. The human IL10 shows 81% homology with murine IL10 at the nucleotide level.
  • a receptor has been identified on murine and human cells by using radiolabeled IL10 (e.g. polypeptides encoded by Genbank Accession No. L12120, U00672).
  • Mouse IL10 is capable of blocking binding of human IL10 to mouse but not human cells.
  • the murine IL10 receptor has been cloned. This receptor is a protein of approximately 110 kDa that binds murine IL10 specifically. This receptor is structurally related to receptors for IFN.
  • IL10 inhibits the synthesis of a number of cytokines such as IFN-gamma, IL2 and TNF-beta in Th1 subpopulations of T-cells but not of Th2 cells. This activity is antagonized by IL4.
  • the inhibitory effect on IFN-gamma production is indirect and appears to be the result of a suppression of IL12 synthesis by accessory cells.
  • IL10 is produced by, and down-regulates the function of, Th1 and Th2 cells.
  • macrophages stimulated by bacterial lipopolysaccharides IL10 inhibits the synthesis of IL1, IL6 and TNF-alpha by promoting, among other things, the degradation of cytokine mRNA. It also leads to an inhibition of antigen presentation.
  • IFN-gamma and IL1 antagonize each other's production and function.
  • IL10 has been shown also to be a physiologic antagonist of IL12.
  • IL10 also inhibits mitogen- or anti-CD3-induced proliferation of T-cells in the presence of accessory cells and reduces the production of IFN-gamma and IL2. Exogenous 1L2 and IL4 inhibit the proliferation-inhibitory effect but do not influence the production of IFN-gamma. In LPS-stimulated macrophages IFN-gamma increases the synthesis of IL6 by inhibiting the production of IL10. IL10 appears to be responsible for most or all of the ability of Th2 supernatants to inhibit cytokine synthesis by Th1 cells.
  • IL10 inhibits secretion of Ig by T-cell-independent antigens induced by IL5 but not that induced by IL2.
  • Murine Ly-1 B cells are the principal source of IL10. In contrast to other B-cells, Ly-1 B-cells express greatly elevated constitutive and inducible levels of IL10. These cells also have the distinctive property of continuous self-replenishment. The continuous treatment of newborn mice with anti-IL10 antibodies leads to a depletion of the Ly-1 B-cells while maintaining a normal population of splenic B-cells. These mice also contain greatly reduced serum immunoglobulin M levels and are also impaired in their antibody responses to specific antigens. IL10 is therefore a regulator of Ly-1 B-cell development. The mechanism of Ly-1 B-cell depletion appears to involve the increased production of IFN-gamma since co-administration of neutralizing anti-IFN-gamma antibodies substantially restores the number of peritoneal-resident Ly-1 B-cells in these mice.
  • IL10 is also a costimulator for the growth of mature and immature thymocytes (together with IL2, IL4 and IL7) and functions as a cytotoxic T-cell differentiation factor, promoting a higher number of IL2-activated cytotoxic T-lymphocyte precursors to proliferate and differentiate into cytotoxic effector cells.
  • IL10 sustains viability of B-cells in vitro and also stimulates B-cells and promotes their differentiation. It enhances the expression of MHC class II antigens on B-cells whereas it inhibits MHC class II expression on monocytes.
  • B-cells activated via their antigen receptors or via CD40 IL10 induces the secretion of IgG, IgA and IgM. This effect is synergised by IL4 while the synthesis of immunoglobulins induced by IL10 is antagonized by TGF-beta. The activation of macrophages can be prevented by IL10.
  • human IL10 is a potent and specific chemoattractant for human T-lymphocytes.
  • the chemotactic activity is directed towards cells expressing CD8 and not towards CD4 (+)cells.
  • IL10 also inhibits the chemotactic response of CD4 (+)cells, but not of CD8 (+)cells, towards IL8.
  • IL10 can be detected with a sensitive ELISA assay.
  • the murine mast cell line D36 can be used to bioassay human IL10.
  • the intracellular factor can be detected also by flow cytometry.
  • IL10 expression vector into CHO cells has been used to analyze the consequences of local IL10 production in vivo. These altered cells were no longer tumorigenic in nude mice or severe combined immunodeficient SCID mice and also suppressed the growth of equal numbers of co-injected normal CHO cells. While normal CHO tumors are usually substantially infiltrated by macrophages, these were virtually absent within CHO-IL10 tumor tissues, suggesting that IL10 indirectly suppresses tumor growth of certain tumors by inhibiting infiltration of macrophages which may provide tumor growth promoting activity.
  • Human IL12 is a heterodimeric 70 kDa glycoprotein consisting of a 40 kDa subunit (p40, 306 amino acids; 10% carbohydrate) and a 35 kDa subunit (p35, 197 amino acids; 20% carbohydrate) linked by disulfide bonds that are essential for the biological activity of IL12.
  • p40 contains 10 cysteines and a binding site for heparin;
  • p35 contains 7 cysteines.
  • the two subunits of IL12 are not related to any other known proteins.
  • p40 shows some homology with the extracellular domain of the receptor for IL6, and p35 appears to be a homologue of IL6.
  • Bioactive murine and human IL12 fusion proteins combining the two IL12 subunits in a single molecule have been described. This designer cytokine retains antitumor activity in vivo. Flexi 12, a single chain protein retaining all of the biological characteristics of the dimeric recombinant IL12, has also been described.
  • the gene encoding the p40 subunit of IL12 maps to human chromosome 5q31-q33 in the same region that also harbors other cytokine genes.
  • the gene encoding the p35 subunit of IL12 maps to human chromosome 3p 12-q 13.2. The expression of the two genes is regulated independently of each other.
  • the IL12 receptor appears to be a single protein of approximately 110 kDa (e.g. polypeptides encoded by Genbank Accession No. U03187, U23922, U64198, U64199). Up to 1000-9000 high affinity IL12 receptors/cell are expressed on peripheral blood mononuclear cells activated by various T-cell mitogens or by IL2. IL12 receptors are present on activated T-cells expressing CD4 and CD8 and on activated CD56 positive natural killer cells. Resting peripheral blood mononuclear cells, tonsillar B-cells, or tonsillar B-cells activated by anti-IgM/Dx, anti-IgM/Dx+IL2, or SAC+IL2 do not express the receptor. High affinity IL12 receptors are expressed constitutively on a transformed marmoset NK-like cell line, HVS.SILVA 40.
  • Binding of IL12 to its receptor can be prevented by monoclonal antibodies directed against the p40 subunit which therefore contains the binding site.
  • the p40 subunit of IL12 shows homology with the extracellular domain of the IL6 receptor.
  • a virus-encoded homologue of the p40 subunit is EBV-induced gene-3.
  • Human IL12 is not active in murine lymphocytes. Hybrid heterodimers consisting of murine p35 and human p40 subunits retain bioactivity on murine cells; however, the combination of human p35 and murine p40 is completely inactive on murine cells. Murine IL12 is active on both murine and human lymphocytes.
  • the p40 subunit of murine IL12 subunit p40 (IL12p40) has been shown to specifically antagonize the effects of the IL12 heterodimer in different assay systems and to function as an endogenous specific inhibitor for the IL12 heterodimer.
  • IL12 stimulates the proliferation of human lymphoblasts activated by phytohemagglutinin. IL12 activates NK-cells positive for CD56, and this activity is blocked by antibodies specific for TNF-alpha. IL12 promotes specific allogenic CTL reactions. IL12 synergizes also with anti-CD3 antibodies and with allogeneic stimulation in mixed lymphocyte cultures in inducing T-cell proliferation.
  • IL12 In peripheral lymphocytes of the Th1 type IL12 induces the synthesis of IFN-gamma and IL2, and TNF. TNF-alpha also appears to be involved in mediating the effects of IL12 on natural killer cells since the effects of IL12 are inhibited by an antibody directed against TNF-alpha. IL12 and TNF-alpha are costimulators for IFN-gamma production with IL12 maximizing the IFN-gamma response; the production of IL12, TNF, and IFN-gamma is inhibited by IL10. In Th2 helper cells IL12 reduces the synthesis of IL4, IL5, and IL10.
  • IL12 synergises with suboptimal amounts of IL2 in promoting the proliferation of mononuclear cells in the peripheral blood and in promoting the generation of LAK cells (lymphokine activated killer cells).
  • Picomolar concentrations of IL12 are as effective as nanomolar concentrations of IL2 in augmenting the cytolytic activity of natural killer cells expanded in vivo by IL2.
  • IL12 also acts as a co-mitogen and potentiates the proliferation of resting peripheral cells induced by IL2.
  • IL12 enhances myelopoiesis of primitive bone marrow progenitor cells induced by SCF (stem cell factor) and synergizes with colony stimulating factors to induce proliferation. IL12 also has synergistic effects on more committed bone marrow progenitors, synergising with IL3, IL11, or IL3 plus SCF.
  • IL12 is potential clinical interest since it allows the reduction of doses of IL2 required for the generation of LAK cells (lymphokine-activated killer cells).
  • IL12 has been shown to inhibit the growth of a variety of experimental tumors in vivo and to have antiangiogenic effects in vivo, which are, at least in part, mediated by IFN-gamma. IL12 therefore seems to be a potential candidate also for the treatment of angiogenesis-dependent malignancies.
  • IL19 and IL10 share 21 percent amino acid identity and are probably homologs.
  • monocytes treatment with bacterial lipopolysaccharides induces the synthesis of IL19 and this effect is potentiated in the presence of IL4 or IL13 but is unaffected by IFN-gamma.
  • GM-CSF directly induces IL19 gene expression in monocytes.
  • IL19 has been shown to bind to the IL20 receptor complex (Dumoutier L et al Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.
  • IL20 is structurally related to IL10.
  • IL20 appears to be an autocrine factor for keratinocytes that regulates their participation in inflammation.
  • Overexpression of IL20 in transgenic mice causes neonatal lethality with skin abnormalities characterized by an impairment of epidermal differentiation (Blumberg H et al Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 104(1): 9-19 (2001); Dumoutier L et al Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.
  • An IL20 receptor has been identified to consist of two orphan class 2 cytokine receptor subunits. The receptor is expressed in skin and its expression is upregulated dramatically in psoriatic skin. Engagement of the receptor in a keratinocyte cell line involves signaling by one member of the STAT proteins, STAT3.
  • the IL20 receptor complex has been shown to bind also IL19 and IL24.
  • IL21 has been isolated by Parrish-Novak et al from a cDNA library derived from activated CD3 (+)T-cells in a search for the ligand of a type-I cytokine receptor isolated previously.
  • the cDNA encodes a secreted protein of 131 amino acids protein most closely related to IL2 and IL15.
  • the IL21 gene maps to human chromosome 4q26-q27 near the IL2 gene.
  • IL21 mRNA is expressed in CD4 (+) but not in CD8 (+) T-cells after cell activation.
  • IL21 stimulates proliferation of B-cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL4 plus anti-IgM. IL21 augments stimulation of the proliferation of naive (CD45RA (+)) but not memory (CD45RO (+)) T-cells mediated by engagement of CD3. IL21 stimulates the proliferation of bone marrow progenitor cells and the expression of the NK-cell marker CD56 in the presence of IL15.
  • the IL21 receptor has been isolated by Parrish-Novak et al and found to be expressed by CD23 (+)B-cells, B-cell lines, a T-cell leukemia line, and NK-cell lines.
  • the receptor gene has been mapped to human chromosome 16p12.
  • the same receptor has been isolated by Ozaki et al, who called it NILR (novel interleukin receptor).
  • the receptor (538 amino acids) is most closely related to human IL2 beta receptor.
  • the receptor contains a WSXWS motif in the extracellular region, typical of type-1 cytokine receptors.
  • the receptor is expressed on NK-cells, T-cells, and B-cell lines.
  • the common gamma chain which is an indispensable subunit of the functional receptor complexes for IL2, IL4, 1L7, IL9, and IL15 has been shows also to be part of the IL21 receptor complex.
  • the functional signalling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3 (Asao et al).
  • IL22 180 amino acids including a signal sequence; 25 kDa; also called IL-TIF was identified by a cDNA subtraction method as a gene induced specifically by IL9 in mouse T lymphocytes.
  • the protein shows limited homology with IL10 (22 percent amino acid identity).
  • Human and murine IL-TIF proteins share 79 percent amino acid identity.
  • the murine and human IL-TIF genes both consist of 6 exons.
  • the human single-copy gene maps to chromosome 12q15 (90 Kb from the IFN-gamma gene, and 27 Kb from the AK155 gene encoding another IL10-related cytokine. In mice the gene is located also in the same region as the IFN-gamma gene. In BALB/c and DBA/2 mice the gene is a single copy gene. In C57B1/6, FVB and 129 mice the gene is duplicated.
  • IL-TIF-alpha and IL-TIF-beta show 98 percent nucleotide identity in the coding region and differ by a deletion of 658 nucleotide in IL-TIF-beta. This gene may be inactive.
  • IL-TIF is induced by IL9 in thymic lymphomas, T-cells, and mast cells, and by lectins in freshly isolated splenocytes.
  • IL-TIF expression in T-cells does not require protein synthesis, and depends on the activation Janus kinases and STAT proteins.
  • IL-TIF is expressed constitutively in thymus and brain.
  • IL-TIF up-regulates the production of acute phase proteins.
  • IL-TIF also acts as a pro-inflammatory cytokine in vivo because injection of the protein also induces the synthesis of acute phase proteins. Synthesis of IL-TIF is induced rapidly after injection of bacterial lipopolysaccharides.
  • IL22 does not inhibit the production of pro-inflammatory cytokines by monocytes in response to bacterial lipopolysaccharides. It also does not impair IL10 function on monocytes.
  • IL-TIF has some inhibitory effects on IL4 production from Th2 T-helper cells.
  • IL10 and IL-TIF utilise a common receptor subunit.
  • Antibodies directed against the beta chain of the IL10 receptor block the induction of acute phase proteins by IL-TIF.
  • the functional IL-TIF receptor complex consists of two receptor chains. One chain has been identified as the orphan receptor CRF2-4 that is expressed in normal liver and kidney. The other chain is the L10 receptor-2, the second chain of the IL10 receptor complex. Monkey COS expressing CRF2-9 alone respond to IL-TIF. In hamster cells both chains must be expressed to yield functional IL-TIF receptors. Although both receptor chains can bind IL-TIF independently binding of IL-TIF to the receptor complex is greater.
  • This sharing of receptor subunits is similar to the shared use of the common gamma chain by cytokines such as IL2, IL4, IL7, IL9, and IL15.
  • cytokines such as IL2, IL4, IL7, IL9, and IL15.
  • Some cell lines that do not respond to IL10 respond to IL-TIF by activation of STAT-1, STAT-3, and STAT-5.
  • IL22BP IL22 binding protein
  • IL22BP also blocks induction of the suppressors of cytokine signaling-3 (SOCS-3) gene expression by IL22 in HepG2 cells (Dumoutier L et al Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. Journal of Immunology 164(4): 1814-1819 (2000); Dumoutier L et al Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.
  • SOCS-3 cytokine signaling-3
  • IL-23 is the name given to a factor that is composed of the p40 subunit of IL12 (IL12B) and another protein of 19 kDa, designated p19.
  • p19 is structurally related to IL6, G-CSF, and the p35 subunit of IL12. In databanks the p19 subunit is found also under the acronym SGRF (IL6 G-CSF related factor).
  • p19 by itself is biologically inactive while the complex of p19 with p40 is active.
  • the active complex is secreted by dendritic cells after cell activation.
  • Mouse memory T-cells proliferate in response to IL23 but not in response to IL12.
  • Human IL23 has been shown to stimulate the production of IFN-gamma by PHA blast T-cells and memory T-cells. It also induces proliferation of both cell types.
  • IL23 binds to the beta-1 subunit but not to the beta-2 subunit of the IL12 receptor, activating one of the STAT proteins, STAT4, in PHA blast T-cells.
  • p19 in transgenic mice leads to runting, systemic inflammation, infertility, and death before 3 months of age.
  • the animals show high serum concentrations of the pro-inflammatory cytokines TNF-alpha and IL1.
  • the number of circulating neutrophils is increased.
  • Acute phase proteins are expressed constitutively.
  • Animals expressing p19 specifically in the liver do not show these abnormalities.
  • Expression of p19 is most likely due to hematopoietic cells as bone marrow transplantation of cells expressing p19 causes the same phenotype as that observed in the transgenic animals (Oppmann B et al Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
  • IL24 is a name given to a protein that is known also as ST16 [suppression of tumorigenicity-16] and MDA-7 [melanoma differentiation-associated gene 7].
  • ST16 suppression of tumorigenicity-16
  • MDA-7 melanoma differentiation-associated gene 7.
  • the rat counterpart of IL24 has been identified as mob-5 or C49a.
  • the murine counterpart is FISP.
  • MDA-7 protein (206 amino acids) was identified initially as a melanoma differentiation-associated cDNA in a study using cultured human melanoma cells that lose proliferative capacity and terminally differentiate in response to human IFN-beta and mezerein.
  • the expression of MDA-7 is upregulated as a consequence of terminal differentiation.
  • H0-1 and C8161 human melanoma cells engineered to express MDA-7 show reduces growth and do not form colonies in a colony formation assay.
  • MDA-7 selectively suppresses the growth of human breast cancer cells by promoting cell death by apoptosis.
  • Ectopic expression of MDA-7 by means of a replication defective adenovirus results in growth suppression and induction of apoptosis in a broad spectrum of additional cancers, including melanoma, glioblastoma multiforme, osteosarcoma and carcinomas of the breast, cervix, colon, lung, nasopharynx and prostate. No apparent harmful effects are observed after expression of MDA-7 in normal epithelial or fibroblast cells.
  • MDA-7 expression is induced during megakaryocyte differentiation in response to treatment with TPA (12-O-tetradecanoyl-phorbol-13-acetate).
  • the human MDA-7 gene maps to chromosome 1q32 and is tightly linked (within a region of 195 kb) to the genes encoding IL10, IL19, and IL20.
  • the receptor for IL24 has been identified as the IL20 receptor complex. This receptor also binds to IL19 (Blumberg H et al Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 104(1): 9-19 (2001); Dumoutier L et al Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Journal of Immunology 167(7): 3545-9 (2001); Huang E Y et al Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.
  • mda-7 novel melanoma differentiation associated
  • IL25 also known as SF20
  • SF20 bone marrow stromal cells
  • the IL25 receptor has been identified as mouse thymic shared antigen-1 (TSA-1). Enforced expression of the receptor in one of the factor-dependent cell lines, BaF3, which does not express the receptor, causes cell proliferation. FDCP2 cells, which express the receptor, also proliferate in response to SF20/IL25. In both cases proliferation is abolished by specific blocking antibodies directed against the receptor.
  • TSA-1 mouse thymic shared antigen-1
  • SF20/IL-25 has no detectable myelopoietic activity but supports proliferation of cells in the lymphoid lineage (Tulin E E et al SF20/IL-25, a Novel Bone Marrow Stroma-Derived Growth Factor That Binds to Mouse Thymic Shared Antigen-1 and Supports Lymphoid Cell Proliferation. Journal of Immunology 167(11): 6338-47 (2001)).
  • TNFalpha The members of the TNF ligand superfamily (TNFalpha, TNF-beta, LT beta, CD27 ligand, CD30 ligand, CD40 ligand, CD95 ligand, 41BB, OX40 ligand, TRAIL) share common biological activities, but some properties are shared by only some ligands, while others are unique.
  • Human TNF-alpha is a non-glycosylated protein of 17 kDa and a length of 157 amino acids.
  • Murine TNF-alpha is N-glycosylated. Homology with TNF-beta is approximately 30%.
  • TNF-alpha forms dimers and trimers.
  • the 17 kDa form of the factor is produced by processing of a precursor protein of 233 amino acids.
  • a TNF-alpha converting enzyme has been shown to mediate this conversion.
  • a transmembrane form of 26 kDa has been described also.
  • TNF-alpha contains a single disulfide bond that can be destroyed without altering the biological activity of the factor. Mutations Ala84 to Val and Val91 to Ala reduce the cytotoxic activity of the factor almost completely. These sites are involved in receptor binding. The deletion of 7 N-terminal amino acids and the replacement of Pro8Ser9Asp10 by ArgLysArg yields a mutated factor with an approximately 10-fold enhanced antitumor activity and increased receptor binding, as demonstrated by the L-M cell assay, while at the same time reducing the toxicity.
  • the gene has a length of approximately 3.6 kb and contains four exons.
  • the primary transcript has a length of 2762 nucleotides and encodes a precursor protein of 233 amino acids.
  • the aminoterminal 78 amino acids function as a presequence.
  • the human gene maps to chromosome 6p23-6q12. It is located between class I HLA region for HLA-B and the gene encoding complement factor C.
  • the gene encoding TNF-beta is approximately 1.2 kb downstream of the TNF-alpha gene. However, both genes are regulated independently. The two genes also lie close to each other on murine chromosome 17.
  • Two receptors of 55 kDa (TNF-R1; new designation: CD120a) (e.g. polypeptides encoded by Genbank Accession No. X55313) and 75 kDa (TNF-R2; new designation: CD120b) (e.g. as described in Goodwin R G et al (1991) Molecular Cellular Biology 11: 3020-6) have been described.
  • One receptor is a glycosylated protein of 455 amino acids that contains an extracellular domain of 171 and a cytoplasmic domain of 221 amino acids. Sequence homologies in the cysteine-rich domains of the extracellular portion reveal that the receptor is related to the low-affinity receptor of NGF and to human cell surface antigen CD40.
  • TNF-R1 Deletion analysis in the C-terminal intracellular region of the 55 kDa receptor, TNF-R1 has revealed the existence of a so-called death domain, which is involved in signaling processes leading to programmed cell death.
  • the death domain of TNF-R1 interacts with a variety of other signaling adaptor molecules, including TRADD, and RIP.
  • the two known receptors bind both TNF-alpha and TNF-beta.
  • p55 is expressed particularly on cells susceptible to the cytotoxic action of TNF.
  • p75 is also present on many cell types, especially those of myeloid origin (a virus-encoded homologue of the receptor subunit is EBV-induced gene-6). It is strongly expressed on stimulated T-cells and B-lymphocytes.
  • the differential activities of TNF on various cell types, i.e. growth-promoting and growth-inhibiting activities, are probably mediated by the differential expression and/or regulation of multiple receptors in combination with other distinct receptor-associated proteins.
  • p55 appears to play a critical role in host defenses against microorganisms and their pathogenic factors.
  • a third receptor subtype is expressed in normal human liver. It binds TNF-alpha but not TNF-beta. Some viruses contain genes encoding secreted proteins with TNF binding properties that are closely homologous to the p55 and p75 TNF receptors. Differential effects of the two receptor subtypes have been found also in TNF-mediated adhesion of leukocytes to the endothelium. It appears that engagement of the p55 receptor specifically leads to the induction of the cellular adhesion molecules ICAM-1, E-selectin, V-CAM-1, and CD44, while engagement of both the p55 and the p75 receptor induces expression of alpha-2 integrin.
  • Truncated soluble forms of the receptor have been found also.
  • the soluble forms in particular the soluble extracellular domain of the p60 receptor, block the antiproliferative effects of TNF and, therefore, may modulate the harmful effects of TNF.
  • Receptor densities are reduced by IL1 and tumor promoters such as phorbol esters.
  • the expression of TNF-alpha receptor density is induced by IFN-alpha, IFN-beta, and IFN-gamma.
  • TRAF Tumor necrosis factor receptor-associated factors
  • TNF-alpha Human TNF-alpha is active on murine cells with a slightly reduced specific activity.
  • TNF-alpha and TNF-beta display similar spectra of biological activities in in-vitro systems, although TNF-beta is often less potent or displays apparent partial agonist activity.
  • TNF-alpha shows a wide spectrum of biological activities. It causes cytolysis and cytostasis of many tumor cell lines in vitro. Sensitive cells die within hours after exposure to picomolar concentrations of the factor and this involves, at least in part, mitochondria-derived second messenger molecules serving as common mediators of TNF cytotoxic and gene-regulatory signaling pathways. The factor induces hemorrhagic necrosis of transplanted tumors. Within hours after injection TNF-alpha leads to the destruction of small blood vessels within malignant tumors. The factor also enhances phagocytosis and cytotoxicity in neutrophilic granulocytes and also modulates the expression of many other proteins, including fos, myc, IL1 and IL6.
  • TNF 26 kDa form of TNF is found predominantly on activated monocytes and T-cells. It is also biologically active and mediates cell destruction by direct cell-to-cell contacts.
  • TNF-alpha The chemotactic properties of fMLP (Formyl-Met-Leu-Phe) for neutrophils are enhanced by TNF-alpha.
  • TNF-alpha induces the synthesis of a number of chemoattractant cytokines, including IP-10, JE, KC, in a cell-type and tissue-specific manner.
  • TNF-alpha is a growth factor for normal human diploid fibroblasts. It promotes the synthesis of collagenase and prostaglandin E2 in fibroblasts. It may also function as an autocrine growth modulator for human chronic lymphocytic leukemia cells in vivo and has been described to be an autocrine growth modulator for neuroblastoma cells. The autocrine growth-promoting activity is inhibited by IL4.
  • TNF In resting macrophages TNF induces the synthesis of IL1 and prostaglandin E2. It also stimulates phagocytosis and the synthesis of superoxide dismutase in macrophages. TNF activates osteoclasts and thus induces bone resorption.
  • TNF stimulates the expression of class I and II HLA and differentiation antigens, and the production of IL1, colony stimulating factors, IFN-gamma, and arachidonic acid metabolism. It also stimulates the biosynthesis of collagenases in endothelial cells and synovial cells.
  • IL6 suppresses the synthesis of IL1 induced by bacterial endotoxins and TNF, and the synthesis of TNF induced by endotoxins.
  • the neurotransmitter SP induces the synthesis of TNF and IL1 in macrophages.
  • IL1 like IL6, stimulates the synthesis of ACTH (corticotropin) in the pituitary.
  • ACTH corticotropin
  • Glucocorticoids synthesized in response to ACTH in turn inhibit the synthesis of IL6, IL1 and TNF in vivo, thus establishing a negative feedback loop between the immune system and neuroendocrine functions.
  • TNF-alpha enhances the proliferation of T-cells induced by various stimuli in the absence of IL2. Some subpopulations of T-cells only respond to IL2 in the presence of TNF-alpha. In The presence of IL2 TNF-alpha promotes the proliferation and differentiation of B-cells.
  • the functional capacities of skin Langerhans cells are also influenced by TNF-alpha. These cells are not capable of initiating primary immune responses such as contact sensibilisation. They are converted into immunostimulatory dendritic cells by GM-CSF and also IL1. These cells therefore are a reservoir for immunologically immature lymphoid dendritic cells. The enhanced ability of maturated Langerhans cells to process antigens is significantly reduced by TNF-alpha.
  • TNF-alpha is also required for normal immune responses the overexpression has severe pathological consequences.
  • TNF-alpha is the major mediator of cachexia observed in tumor patients (hence its name, cachectin). TNF is also responsible for some of the severe effects during Gram-negative sepsis.
  • TNF-alpha can be detected in bioassays involving cell lines that respond to it (e.g., BT-20, CT6, EL4; PK15; L929; L-M; M07E; T1165; WEHI-3B).
  • TNF-alpha can be detected also by a sensitive sandwich enzyme immunoassay, ELISA, an immunoradiometric assay (IRMA), and by an assay designated RELAY (receptor-mediated label-transfer assay).
  • Intracellular factor is detected by two color immunofluorescence flow cytometry.
  • Higuchi et al have described an assay based on the release of tritiated thymidine from cells undergoing apoptosis after treatment with either TNF-alpha or TNF-beta.
  • IFN-alpha, IFN-beta, IFN-gamma, TGF-beta, IL4, LIF and GM-CSF have been shown not to interfere with this assay.
  • TNF specifically attacks malignant cells.
  • Extensive preclinical studies have documented a direct cytostatic and cytotoxic effect of TNF-alpha against subcutaneous human xenografts and lymph node metastases in nude mice, as well as a variety of immunomodulatory effects on various immune effector cells, including neutrophils, macrophages, and T-cells.
  • Single- and multiple-dose phase I studies have confirmed that TNF can be administered safely to patients with advanced malignancies in a dose range associated with anticancer effect without concomitant serious toxicities such as shock and cachexia.
  • TNF-induced systemic toxicity being a major limitation for the use of TNF as an antineoplastic agent in most cases.
  • the combined use of TNF and cytotoxic or immune modulatory agents, particularly IFN-gamma and possibly IL2 may be of advantage in the treatment of some tumors.
  • intratumoral application of TNF has been found to be of advantage in tumor control.
  • TNF-beta TNF-beta with selective activity on the p55 receptor have been described recently. It has been shown that activation of the p55 receptor is sufficient to trigger cytotoxic activity towards transformed cells. Some of these mutants have been described to retain their antitumor activity in nude mice carrying transplanted human tumors.
  • TNF can also be used to increase the aggressiveness of lymphokine-activated killer cells.
  • Studies with an experimental fibrosarcoma metastasis model have shown that TNF induces significant enhancement of the number of metastases in the lung. It has been suggested that low doses of endogenous TNF or administration of TNF during cytokine therapy may enhance the metastatic potential of circulating tumor cells.
  • the transduction of murine tumor cells with a functional TNF-alpha gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts.
  • the interferons are a family of cytokines that induce a virus-nonspecific antiviral state in target cells. Binding of an interferon to its receptor induces new protein synthesis which, in turn, results in the inactivation of initiation factor eIF-2. The inactivation is thought to contribute to the antiviral state induced by the interferons. Interferons also induce pathways that activate intracellular endonucleases which degrade viral mRNA. Many interferons also possess immunomodulatory activities, such as activation of macrophages and lymphocytes. Examples of interferons include IFN-gamma (e.g. polypeptides encoded by Genbank Accession No.
  • IFN-gamma e.g. polypeptides encoded by Genbank Accession No.M28622, X14029, X14455, K00020, J00218, E00171, X04430, A09363, M27327, M16656, M25460, K03196
  • IFN-gamma e.g. polypeptides encoded by Genbank Accession No.
  • IFN-gamma e.g. polypeptides encoded by Genbank Accession No. X58822, A12140
  • bovine trophoblast protein-1 IFN-gamma
  • Human IFN-gamma and IFN-gamma are thought to bind to a common receptor (e.g. polypeptides encoded by Genbank Accession No. X60459, M89641) which is distinct from the receptor for IFN-gamma (e.g. polypeptides encoded by Genbank Accession No. J03143, M28233).
  • the individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172
  • IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end. Disulfide bonds are formed between cysteines at positions 1/98 and 29/138. The disulfide bond 29/138 is essential for biological activity while the 1/98 bond can be reduces without affecting bioactivity.
  • Human IFN-beta is a glycoprotein (approximately 20% sugar moiety) of 20 kDa and has a length of 166 amino acids. Glycosylation is not required for biological activity in vitro. The protein contains a disulfide bond Cys31/141) required for biological activity.
  • IFN-beta displays 34% sequence homology with IFN-beta-2 and approximately 30% homology with other IFN-alpha subtypes. In contrast to IFN-gamma IFN-beta is stable at pH2.
  • Human IFN-gamma is a dimeric protein with subunits of 146 amino acids. The protein is glycosylated at two sites. The pI is 8.3-8.5. IFN-gamma is synthesized as a precursor protein of 166 amino acids including a secretory signal sequence of 23 amino acids. Two molecular forms of the biologically active protein of 20 and 25 kDa have been described. Both of them are glycosylated at position 25. The 25 kDa form is also glycosylated at position 97. The observed differences of natural IFN-gamma with respect to molecular mass and charge are due to variable glycosylation patterns. 40-60 kDa forms observed under non-denaturing conditions are dimers and tetramers of IFN-gamma.
  • cytokines allow the growth and differentiation of bone marrow cells immobilized on soft agar or methylcellulose. While hematopoietic progenitor cells can be maintained only for short periods of time in the absence of such factors, their presence allows the development of colonies containing erythroid cells, neutrophils, eosinophils, macrophages, and/or megakaryocytes, depending on the particular factor. The biochemical analysis of various activities stimulating colony formation supporting the growth and development of these cell types revealed that there existed many different and distinct factors of this sort.
  • Colony stimulating factors are produced by many different cell types, including, for example, B-lymphocytes, epithelial cells, fibroblasts, endothelial cells, macrophages, Stromal cell line, T-lymphocytes. They are synthesized as precursor molecules containing a classical hydrophobic secretory signal sequence of approximately 25-32 amino acids. The secreted factors have an extremely high specific biological activity are active at very low concentrations (1-100 pM). These factors are absolutely required for the proliferation of hematopoietic progenitor cells. The concentrations required for mere maintenance of viability are usually orders of magnitude lower than those required to induce cell proliferation or to elicit specific functional activities of the cells.
  • the names of the individual factors usually indicate the cell types that respond to these factors.
  • the classical colony stimulating factors include M-CSF (e.g. polypeptides encoded by Genbank Accession No. E03235, M64592, U22386, X05010) (macrophage-specific), G-CSF (granulocyte-specific), GM-CSF (macrophage/granulocyte-specific), IL3 (multifunctional) and MEG-CSF (e.g. polypeptides encoded by Genbank Accession No.D86370, U70136) (megakaryocyte-specific).
  • G-CSF and M-CSF are lineage-specific while GM-CSF and IL3 are multifunctional hematopoietic growth factors acting on earlier stages of differentiation of hematopoietic progenitor cells.
  • Human GM-CSF is a monomeric protein of 127 amino acids with two glycosylation sites.
  • the protein is synthesized as a precursor of 144 amino acids, which included a hydrophobic secretory signal sequence at the aminoterminal end.
  • the sugar moiety is not required for the full spectrum of biological activities.
  • Non-glycosylated and glycosylated GM-CSF show the same activities in vitro.
  • Fully glycosylated GM-CSF is biologically more active in vivo than the non-glycosylated protein.
  • the different molecular weight forms of GM-CSF (14 kDa, 35 kDa) described in the literature are the result of varying degrees of glycosylation.
  • GM-CSF contains four cysteine residues (positions 54/96 and 88/121).
  • GM-CSF can be associated with the extracellular matrix of cells as a complex with heparan sulfate proteoglycans. This allows storage of the factor in a biologically inactive form. The exact mechanism by which the factor is eventually released from these depots is not known.
  • the human gene has a length of approximately 2.5 kb and contains four exons. The distance between the GM-CSF gene and the IL3 gene is approximately 9 kb.
  • the human GM-CSF gene maps to chromosome 5q22-31 in the vicinity of other genes encoding hematopoietic growth factors (M-CSF, IL3, IL4, IL5) and the gene encoding the M-CSF receptor.
  • M-CSF, IL3, IL4, IL5 hematopoietic growth factors
  • the 5′ region of the GM-CSF gene contains several sequence elements known as CLE (conserved lymphokine element). They function as binding sites for transcription factors, modulating the expression of the GM-CSF gene.
  • GM-CSF receptors are expressed at densities of several 100 to several 1000 copies/cell on the cell surface of myeloid cells.
  • the receptor is expressed also on non-hematopoietic cells such as endothelial cells and small cell lung carcinoma cells. In receptor-positive cell lineages the receptor density decreases with increasing degrees of maturation.
  • the receptor shows significant homologies with other receptors for hematopoietic growth factors, including IL2-beta, IL3, IL6, IL7, Epo and the prolactin receptors.
  • One cloned subunit of the GM-CSF receptor (GM-R alpha, 45 kDa) binds GM-CSF with low affinity (e.g. polypeptides encoded by Genbank Accession No. SEG_HUMGRAS).
  • the second subunit (GM-R beta, 120 kDa) does not bind GM-CSF.
  • GM-R alpha is a protein of 400 amino acids that contains only a short cytoplasmic domain of 54 amino acids.
  • the high affinity GM-CSF receptor is formed by the aggregation of the two receptor subunits.
  • the GM-R beta subunit of the receptor e.g. polypeptides encoded by Genbank Accession No. SEG_MUSAIC2B, M59941
  • SEG_MUSAIC2B Genbank Accession No. SEG_MUSAIC2B, M59941
  • AIC2A cytokine-specific subunit
  • GM-CSF Human GM-CSF is not active on murine cells and vice versa.
  • GM-CSF was isolated initially as a factor stimulating the growth of macrophage/granulocyte-containing colonies in soft agar cultures (colony formation assay).
  • GM-CSF is indispensable for the growth and development of granulocyte and macrophage progenitor cells. It stimulates myeloblasts and monoblasts and triggers irreversible differentiation of these cells.
  • GM-CSF synergises with Epo in the proliferation of erythroid and megakaryocytic progenitor cells.
  • M-CSF colony stimulating factor
  • GM-CSF acts as an autocrine mediator of growth.
  • GM-CSF is a strong chemoattractant for neutrophils. It enhances microbicidal activity, oxidative metabolism, and phagocytotic activity of neutrophils and macrophages. It also improves the cytotoxicity of these cells.
  • GM-CSF displays a less pronounced specificity than, for example, G-CSF. It stimulates the proliferation and differentiation of neutrophilic, eosinophilic, and monocytic lineages. It also functionally activates the corresponding mature forms, enhancing, for example, the expression of certain cell surface adhesion proteins (CD-11A, CD-11C).
  • GM-CSF also enhances expression of receptors for fMLP (Formyl-Met-Leu-Phe) which is a stimulator of neutrophil activity.
  • GM-CSF is chemotactic for eosinophils and also influences the chemotactic behavior of these cells in response to other chemotactic factors.
  • GM-CSF In granulocytes GM-CSF stimulates the release of arachidonic acid metabolites and the increased generation of reactive oxygen species. The activation of the Na + /H+ antiport system leads to a rapid alkalization of the cytosol. Phagocytotic activities of neutrophil granulocytes and the cytotoxicity of eosinophils is also enhanced considerably by GM-CSF. Since GM-CSF is produced by cells (T-lymphocytes, tissue macrophages, endothelial cells, mast cells) present at sites of inflammatory responses it can be assumed that it is an important mediator for inflammatory reactions.
  • Langerhans cells of the skin is also influenced by GM-CSF. These cells are not capable of initiating primary immune responses, for example, contact sensibilization. They are converted to highly potent immunostimulatory dendritic cells by GM-CSF (and also IL1). Langerhans cells therefore form an in situ reservoir for immunologically immature lymphoid dendritic cells. The maturation of these cells which is seen as an increased ability to process antigens, can be down-regulated by TNF-alpha.
  • GM-CSF induces the expression of complement C3a receptors on basophils.
  • Cells which normally do not respond to C3a and which have been activated by GM-CSF degranulate in response to the C3a stimulus. This is accompanied by the release of histamine and leukotriene C4. This process may be of significance in hypersensitivity reactions associated with inflammatory responses (T-lymphocytes, tissue macrophages, endothelial cells, mast cells).
  • GM-CSF has been shown also to be a potent inducer of trophoblast interferon (TP-1).
  • GM-CSF synergises with some other cytokines, including IL1, IL3 and G-CSF.
  • GM-CSF and G-CSF must act in concert to allow the development of neutrophil-containing colonies in vitro.
  • IL3 by itself only negligibly expands the number of circulating blood cells; a subsequent dose of GM-CSF, however, significantly increases cell numbers, probably because IL3 first leads to an expansion of those cells capable of responding to GM-CSF.
  • GM-CSF GM-CSF
  • mice generated from ES cells carrying a targeted deletion of the gene The biological consequences of GM-CSF gene disruption have been studied in mice generated from ES cells carrying a targeted deletion of the gene. Mice homozygous for a targeted disruption of the GM-CSF gene are characterized by an unimpaired steady-state hematopoiesis, demonstrating that GM-CSF is not essential for maintaining normal levels of the major types of mature hematopoietic cells and their precursors in blood, marrow, and spleen.
  • GM-CSF-deficient mice are superficially healthy and fertile but develop abnormal lungs. GM-CSF-deficient mice develop a progressive accumulation of surfactant lipids and proteins in the alveolar space, the defining characteristics of the idiopathic human disorder pulmonary alveolar proteinosis. Extensive lymphoid hyperplasia associated with lung airways and blood vessels is found also. These results demonstrate an unexpected, critical role for GM-CSF in pulmonary homeostasis.
  • mice homozygous for null mutations of the gene encoding the common beta subunit (beta C) of the GM-CSF, IL3, and IL5 receptor complexes exhibit normal development and survive to young adult life. They develop pulmonary peribroncnovascular lymphoid infiltrates and areas resembling alveolar proteinosis. Eosinophil numbers in peripheral blood and bone marrow of homozygous deletion mutants are reduced, while other hematological parameters are normal. Bone marrow cells from homozygous deletion mutants do not show high-affinity binding of GM-CSF, while cells from heterozygous animals show an intermediate number of high-affinity receptors.
  • beta C common beta subunit
  • Nishinakamura et al have crossed beta-c mutant mice with mice deficient for IL3.
  • the double-mutant mice lacking all IL3, GM-CSF, and IL5 functions are apparently normally fertile.
  • the animals show the same reduced numbers of eosinophils and a lack of eosinophilic response to parasites as beta-c mutant mice.
  • the immune response of the double mutant mice to Listeria monocytogenes is normal. Hematopoietic recovery after treatment with fluorouracil is also normal.
  • GM-CSF can be assayed in a colony formation assay by the development of colonies containing macrophages, neutrophils, eosinophils, and megakaryocytes. GM-CSF is also detected in specific bioassays with cells lines that depend in their growth on the presence of GM-CSF or that respond to this factor (e.g., AML-193; B6SUt-A; BAC1.2F5; BCL1; Da; FDCP1; GF-D8; GM/SO; IC-2; M07E; NFS-60; PT-18; TALL-103; TF-1; UT-7).
  • AML-193; B6SUt-A BAC1.2F5; BCL1; Da; FDCP1; GF-D8; GM/SO; IC-2; M07E; NFS-60; PT-18; TALL-103; TF-1; UT-7.
  • GM-CSF can be employed for the physiological reconstitution of hematopoiesis in all diseases characterized either by an aberrant maturation of blood cells or by a reduced production of leukocytes.
  • the main and most important clinical application of GM-CSF is probably the treatment of life-threatening neutropenia following chemo and/or radiotherapy, which is markedly reduced under GM-CSF treatment.
  • GM-CSF can be used also to correct chemotherapy-induced cytopenias and to counteract cytopenia-related predisposition to infections and hemorrhages.
  • GM-CSF GM-CSF
  • cytotoxic drug treatment Several studies have demonstrated that the use of GM-CSF enhances tolerance to cytotoxic drug treatment and can be used to prevent dose reductions necessitated by the side effects of cytotoxic drug treatment. GM-CSF treatment frequently permits to increase the doses of cytotoxic drugs per course. These studies have also revealed a significantly reduced morbidity under GM-CSF treatment.
  • the transduction of murine tumor cells with a functional GM-CSF gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts. Moreover, vaccination with GM-CSF transduced tumor cells prevents growth of a subsequent inoculum of wild-type syngeneic tumor cells.
  • chemokine family of cytokines consists of relatively small, structurally similar polypeptides that induce chemotaxis in leukocytes. Chemokines have molecular masses of 8-10 kDa and show approximately 20-50% sequence homology among each other at the protein level. The proteins also share common gene structures and tertiary structures. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
  • chemokines According to the chromosomal locations of individual genes two different subfamilies of chemokines are distinguished. Members of the alpha-chemokines are referred to also as the 4q chemokine family because the genes encoding members of this family map to human chromosome 4q12-21. The first two cysteine residues of members of this family are separated by a single amino acids and these proteins, therefore, are called also C-X-C chemokines.
  • This subfamily includes 9E3 (e.g. Genbank protein P08317), AMCF (e.g. polypeptides encoded by Genbank Accession No. M99367, M99368), beta-thromboglobulin (e.g.
  • CINC family members e.g. polypeptides encoded by Genbank Accession No. D21095
  • ENA-78 e.g. polypeptides encoded by Genbank Accession No. X78686
  • eotaxin e.g. polypeptides encoded by Genbank Accession No. U46572, U40672
  • GCP-2 e.g. polypeptides encoded by Genbank Accession No. Y08770, U83303
  • IL8 IP-10 e.g. polypeptides encoded by Genbank Accession No. L07417, X02530
  • KC e.g.
  • NAP-2 (as described in Clark-Lewis I et al (1991) Biochemistry 30: 3128-35, Cohen A B et al (1992) American Journal of Physiology 263: L249-56)
  • NAP-3 (as described in: Schröder J M et al (1991) Journal of Experimental Medicine 171: 1091-100)
  • NAP-4 (as described in Schröder T M et al (1990) Biochemical zui Biophysical Research Communications 172: 898-904)
  • PBSF (SDF) e.g. polypeptides encoded by Genbank Accession No. D21072, U16752, D50645)
  • PF4 e.g. polypeptides encoded by Genbank Accession No. M25897.
  • IL8 MGSA, mouse KC, MIP-2 (e.g. polypeptides encoded by Genbank Accession No. X65647 and as described in Blum S et al Three human homologues of a murine gene encoding an inhibitor of stem cell proliferation.
  • MIP macrophage inflammatory protein
  • NAP-2, ENA-78, and GCP-2 comprise a subgroup of the human C-X-C-chemokines defined by the conserved ELR sequence motif (glutamic acid-leucine-arginine) immediately preceding the first cysteine residue near the amino-terminal end.
  • Chemokines with an ELR sequence motif have been found to chemoattract and activate primarily neutrophils. Chemokines without the ELR sequence motif appear to chemoattract and activate monocytes, dendritic cells, T-cells, NK-cells, B-lymphocytes, basophils, and eosinophils.
  • ACT-2 e.g. polypeptides encoded by Genbank Accession No. J04130
  • CdO e.g. as described in Berger M S et al (1993) DNA Cell Biol. 12: 839-47.
  • Berger M S et al (1996) ⁇ : 439-447)
  • CCF18 e.g. as described in Hara T et al (1995) Journal of Immunology 155: 5352-8
  • DC-CK1 e.g.
  • ELC e.g. polypeptides encoded by Genbank Accession No. AB000887, AF0592008
  • Eotaxin-2 e.g. as described in Forssmann U et al (1997) Journal of Experimental Medicine 185: 2171-2176
  • Exodus e.g. polypeptides encoded by Genbank Accession No. U64197, U88320, U88321, U88322
  • FIC e.g. polypeptides encoded by Genbank Accession No. L04694
  • GDCF and GDCF-2 e.g.
  • HC-21 e.g. as described in Chang H C & Reinherz E L (1989) European Journal of Immunology 19:1045-1051
  • HCC-1 e.g. polypeptides encoded by Genbank Accession No. Z49270
  • I-309 e.g. polypeptides encoded by Genbank Accession No. M57502
  • JE e.g. polypeptides encoded by Genbank Accession No.
  • LAG-1 lymphocyte activation gene-1
  • LARC lipoprotein suppression factor-1
  • MCP-1 e.g. polypeptides encoded by Genbank Accession No. X14768
  • MCP-2 e.g. polypeptides encoded by Genbank Accession No.
  • MCP-3 e.g. polypeptides encoded by Genbank Accession No. X72308, S71251
  • MCP-4 e.g. polypeptides encoded by Genbank Accession No. X98306
  • MCP-5 e.g. polypeptides encoded by Genbank Accession No. U50712
  • MIP macrophage inflammatory protein
  • MRP-2 e.g. as described in Youn B S et al (1995) Journal of Immunology 155: 2661-7
  • RANTES SDF e.g. polypeptides encoded by Genbank Accession No. M21121, M77747
  • TARC e.g Genbank protein Accession No. Q92583
  • chemokines that comprises neurotactin (e.g. polypeptides encoded by Genbank Accession No. AF010586, which is characterized by a CX(3)C cysteine signature motif.
  • neurotactin e.g. polypeptides encoded by Genbank Accession No. AF010586, which is characterized by a CX(3)C cysteine signature motif.
  • the existence of clearly defined subgroups of chemokines on the basis of structural and functional properties illustrates the importance of chemoattractant diversity in the regulation of leukocyte movement through the body.
  • chemokines The biological activities of chemokines are mediated by specific receptors and also by receptors with overlapping ligand specificities that bind several of these proteins which always belong either to the C-C-chemokines or the group of C-X-C-chemokines.
  • Chemokine receptors belong to the large group of G-protein-coupled seven transmembrane domain receptors which contain seven hydrophobic alpha-helical segments that transverse the membrane. These receptors form a structurally related group within the superfamily of G-protein-coupled receptors which mediate signalling via heterotrimeric G-proteins.
  • CXCR The receptors that bind C-X-C chemokines are designated CXCR followed by a number (e.g., CXCR-1 (e.g. polypeptides encoded by Genbank Accession No. L19591), CXCR-2 (e.g. polypeptides encoded by Genbank Accession No. M94582), CXCR-3 (e.g. polypeptides encoded by Genbank Accession No. X95876), CXCR-4 (e.g. polypeptides encoded by Genbank Accession No. D87747, AF025375) while those binding C-C chemokines are designated CCR followed by a number (e.g., CCR-1 (e.g.
  • polypeptides encoded by Genbank Accession No.L09230, U29678 include CCR-2 (e.g. polypeptides encoded by Genbank Accession No. U29677, U95626), CCR-3 (e.g. polypeptides encoded by Genbank Accession No. U51241), CCR-4 (e.g. polypeptides encoded by Genbank Accession No. X90862, X85740), CCR-5 (e.g. polypeptides encoded by Genbank Accession No. U54994, U83327), CCR-6 (e.g. polypeptides encoded by Genbank Accession No. U95626), CCR-7 (e.g. polypeptides encoded by Genbank Accession No.
  • Viral chemokine receptor homologues include ECRF-3, EBI-1 (EBV-induced gene-1), and US28.
  • chemokines also directly activate cells. Some of them activate granulocytes and/or monocytes and cause respiratory bursts, degranulation, and the release of lysosomal enzymes. Others prime immune cells to respond to sub-optimal amounts of other inflammatory mediators. Yet others have been shown to be potent histamine releasing factors for basophils. It has been proposed that erythrocytes through their promiscuous chemokine receptor play an important role in regulating the chemokine network. Chemokines bound to the erythrocyte receptor are known to be inaccessible to their normal target cells. This appears to provide a sink for superfluous chemokines and may serve to limit the systemic effects of these mediators without disrupting localized processes taking place at the site of inflammation.
  • C-C chemokines exhibit biological activities other than mere chemotaxis. Some chemokines have been shown to be capable of inducing the proliferation and activation of killer cells known as CHAK (C-C-chemokine-activated killer), which are similar to cells activated by IL2.
  • CHAK C-C-chemokine-activated killer
  • flt-3 ligand e.g., polypeptides encoded by Genbank Accession Nos. U04806, U04807, U03858, L23636, U29874, U29875, U44024.
  • This cytokine binds to the flt-3 tyrosine kinase (e.g., polypeptides encoded by Genbank Accession Nos. Z26652, X59398).
  • the human flt-3 ligand also stimulates the proliferation of cells expressing murine flt-3 receptors.
  • flt-3 ligand The effects of flt-3 ligand are synergized by coexpression of G-C SF, GM-C SF, M-CSF, IL3, PIXY-321, and SCF. In combination with SCF and IL3 flt-3 ligand can cause expansion of cells with the marker spectrum CD34 (+)CD38 ( ⁇ ). Alone flt-3 ligand supports the survival of precursor cell types in the lineage of blood-forming cells such as CFU-GM, CFU-GEMM, and the very primitive high proliferative potential colony-forming cells. flt-3 ligand only has marginal effects on erythroid and megakaryocyte progenitor cells.
  • flt-3 ligand potently enhances growth of various types of progenitor/precursor cells in synergy with G-CSF, GM-CSF, M-CSF, IL3, IL6, IL7, IL11, IL12 and SCF.
  • flt-3 ligand supports growth of LTC-IC (long-term culture-initiating cells). The ability of flt-3 ligand to promote the survival of hematopoietic progenitor cells is abrogated by TGF-beta and counteracted by TNF-alpha.
  • BCP-ALL in particular fails to proliferate in the presence of flt-3 ligand despite strong expression of surface flt-3 receptor.
  • an “antitumor cytokine” is a cytokine that can limit the growth or metastasis of tumor cells in vitro or in vivo, or can prolong the survival of a tumor-bearing animal, when either admixed with the cells or administered to the animal.
  • the cytokine can be formulated as a solution in a biologically compatible buffer, e.g. PBS, and admixed with tumor cells in vitro.
  • the concentration of cytokine may be from about the picomolar range to about the micromolar range.
  • An antitumor cytokine will, for example, reduce the growth rate of the cells, e.g.
  • an antitumor cytokine may inhibit the growth or metastasis of a tumor in vivo, or may prolong the survival of a tumor-bearing animal.
  • the cytokine may be formulated in a pharmaceutically acceptable carrier and administered, e.g., by intravenous, intratumoral, or intraperitoneal injection.
  • the cytokine may also be administered in association with cells, such as tumor cells that express or are coated with the cytokine.
  • a cytokine be “bioactive”, “highly bioactive”, “extremely bioactive”, “natively bioactive”, or “suprabioactive”. Different levels of bioactivity relate to the ability to induce a change in a leukocyte (other than mere occupancy of the leukocyte's receptors for the cytokine). According to the invention, all naturally occuring cytokines are natively bioactive. Many types of assay can demonstrate the bioactivity of a non-naturally occurring cytokine. For example, a cytokine may be shown to induce survival and/or proliferation of a particular cell type. As another example, a cytokine may change the concentration of an intracellular second messenger, such as cAMP, arachidonic acid, calcium ions, or inositol triphosphate. The following are examples of assays for bioactivity:
  • Each well of one or more 60-well Lux microtiter trays is loaded with 200 FDC-P1 cells in 10 ul Dulbecco's modified Eagle's medium with a final concentration of 10% newborn calf serum.
  • Cytokine in a concentration in at most the micromolar range is added to each well in a volume of 5 ul.
  • the tray is incubated for 48 h at 37° C. in 10% CO 2 .
  • Viable cell counts are performed. The average number of viable cells/well is counted. This assay is useful, for example, for identifying bioactivity mediated through a murine GM-CSF receptor.
  • Cytokine sample and a recombinant standard identical to a naturally occurring cytokine are each diluted serially in complete RPM1-10 in 96-well flat-bottom microtiter plates. Each dilution is plated in triplicate.
  • CT.4S cells in active log-phase growth are collected, washed at least twice in complete RPM1-10, and resuspended in complete RPM1-10 at 1 ⁇ 10 5 cells/ml. 50 ul of the cell suspension is added to each well of the plate, which is then incubated for 24 h at 37° C. in 5% CO 2 Tritiated thymidine is added to each well and the plate is incubated for an additional 24 h. The cells are then harvested and tritium incorporation is measured by liquid scintillation counting. This assay is useful, for example, for identifying bioactivity mediated through an IL-4 receptor.
  • Agar (4% w/v) is melted in sterile water by boiling 3 min. The agar is then cooled to 42° C. and added to 42° C. RPM1-15 to a final concentration of 0.4%. The solution is maintained at 42° C.
  • Femurs are removed from young mice using sterile technique. Marrow is collected by flushing the opened ends of the bones with sterile Hank's Balanced Salt Solution (HBSS) using a syringe equipped with a 23G needle. Marrow is placed in a 15 ml tissue culture tube and vortexed into a cell suspension. Bone fragments are allowed to settle for 5 min, and the supernatant suspension is removed.
  • HBSS Hank's Balanced Salt Solution
  • Cytokine is diluted serially in RPMI 1640/25 mM HEPES/1% BSA. 25 ul of each dilution is plated in triplicate in a multiwell chemotaxis chamber bottom. Wells containing medium alone serve as negative controls and wells containing chemotaxis-inducing naturally occurring cytokine serve as positive controls.
  • a polycarbonate membrane is placed over the chamber bottom and the chamber is assembled. 50 ul of peripheral blood mononuclear cells at 1.5 ⁇ 10 6 cells/ml in the RPMI/HEPES/BSA is added to each of the upper wells of the chamber. The chamber is incubated for 90 min at 37° C. in 5% CO 2 . The membrane is removed, washed, and stained. Migrated cells in 3-5 random fields of each well are counted by microscopy.
  • Naturally-occurring cytokine reference standard is diluted to 2 ng/ml in a 17 ⁇ 100 mm tube using supplemented medium. 3 further 5-fold serial dilutions are also prepared. Serial dilutions of cytokine are prepared in 17 ⁇ 100 mm tubes from 2 ng/ml to 20 pg/ml. 50 ul of PHA-activated human lymphoblasts 4 ⁇ 10 5 cells/ml in supplemental medium is added to each well of a 96-well flat-bottom microtiter plate. 50 ul of each dilution of reference standard or cytokine is added to triplicate wells. Negative control wells receive 50 ul of supplemented media alone. The plate is incubated for 48 h at 37° C. in 5% CO 2 and the cells are labeled with tritiated thymidine. Incorporation is measured by liquid scintillation counting. This assay is useful, for example, for identifying bioactivity mediated through an IL-12 receptor.
  • an immunocompetent animal is vaccinated with on the order of 10 4 -10 8 irradiated cytokine-transduced or cytokine-coated tumor cells, and challenged with on the order of 10 4 -10 8 live wild-type tumor cells (in any temporal sequence). Readouts of the assay are survival, tumor onset, or number of metastases.
  • cytokine assays can be found, e.g., in: Callard R E et al Assay for human B cell growth and differentiation factors. in: Clemens M J et al (eds) Lymphokines and Interferons. A practical Approach, pp. 345-64, IRL Press, Oxford 1987; Coligan J E et al Current protocols in immunology. Grene and Wiley-Interscience, New York 1991); Dotsika E N Assays for mediators affecting cellular immune functions. Current Opinion in Immunology 2: 932-5 (1989); Feldmann M et al Cytokine assays: role in evaluation of the pathogenesis of autoimmunity.
  • a non-naturally occurring cytokine gives a readout in a bioactivity assay that is at least 10% but not more than 29% (to the nearest 1%) of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “bioactive”.
  • a non-naturally occurring cytokine gives a readout in a bioactivity assay that is at least 30% but not more than 49% (to the nearest 1%) of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “highly bioactive”.
  • a non-naturally occurring cytokine gives a readout in a bioactivity assay that is at least 50% but not more than 69% (to the nearest 1%) of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “extremely bioactive”.
  • a non-naturally occurring cytokine gives a readout in a bioactivity assay that is at least 70% but not more than 100% (to the nearest 1%) of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “natively bioactive”.
  • a non-naturally occurring cytokine gives a readout in a bioactivity assay that is greater than 100% of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “suprabioactive”.
  • CD40 proteins of various species are provided by, e.g. Genbank Accession Nos. Y10507, M83312, and U57745.
  • Human CD40 is a transmembrane glycoprotein with a length of 277 amino acids (48 kDa).
  • CD40 is a phosphoprotein and can be expressed as a homodimer.
  • a soluble form of CD40 28 kDa has also been described.
  • CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T-cells and monocytes, follicular dendritic cells, thymic epithelial cells, and various carcinoma cell lines.
  • CD40 has been demonstrated on the majority of myeloma cell lines and myeloma cells from patients with plasma cell dyscrasia.
  • CD40 mRNA and enhancement of cell surface protein expression in primary human monocytes is observed after treatment with GM-CSF, IL3, or IFN-gamma.
  • the human CD40 gene maps to chromosome 20.
  • CD40 has been proposed to play a role in the development of memory cells. It also plays a role in cell activation, functioning as a competence factor and progression factor. Crosslinking of the CD40 antigen (in combination with cytokines such as IL4 and IL5) leads to B-cell proliferation and induces immunoglobulin class switching from IgM to the synthesis of IgG, IgA, and IgE in the absence of activated T-cells.
  • CD40 is one of the obligatory signals required for commitment of naive B-cells to IgA secretion; the mechanism of IgA induction requires the cooperation of IL10 and TGF-beta. Soluble CD40 inhibits T-cell-dependent B-cell proliferation.
  • Monoclonal antibodies against CD40 mediate a variety of effects on B-lymphocytes, including induction of intercellular adhesion (via CD11a/CD18 (LFA-1)), short- and long-term proliferation, differentiation and enhanced tyrosine phosphorylation of proteins.
  • Germinal center centrocytes are prevented from undergoing cell death by apoptosis by activation through CD40 and antigen receptors.
  • CD40 In human resting B-cells expression of CD40 is induced by IL4. Treatment of human B-cells with IL6 leads to the phosphorylation of the intracellular CD40 domain. CD40 does not, however, function as a receptor for IL6. In activated human B-cells the synthesis of IL6 is induced by treatment of the cells with monoclonal antibodies directed against CD40, suggesting that CD40 participates in signal transduction mechanisms dependent on IL6.
  • CD40 has biological functions also in non-immune cells although these are still largely unknown.
  • CD40 ligation has been shown to induce cell death by apotosis in transformed cells of mesenchymai and epithelial origin. In part these processes are mediated through the death domain present in the cytoplasmic domain of CD40.
  • CD154 (“CD40 ligand”; human protein 29.3 kDa, 261 amino acids) is a member of the TNF family of proteins. The human protein shows 82.8% and 77.4% identity at the cDNA and protein level, respectively, with a similar protein isolated from murine EL4 thymoma cells. Both proteins are the ligands for the CD40 cell surface antigen expressed on resting B-cells.
  • the human gene encoding CD154 maps to chromosome Xq26.3-q27. Nucleotide sequences encoding the native CD40 ligands of various species are provided by, e.g., Genbank Accession Nos.
  • CD154 molecules of various species are provided, e.g., by Entrez protein database Accession Nos. 1705713, 231718, 560693, 3047129, 116000, 1518170, 38412, 109639, 1083014, 38484, and 37270.
  • CD154 is naturally synthesized as a transmembrane polypeptide. Nevertheless, a biologically active soluble fragment of human CD154 has been described (Pietravalle et al, 1996, J Biol Chem 271:5965-5967.)
  • Mazzei et al (1995, J Biol Chem 270:7025-7028) identified a biologically active soluble fragment of CD154 as a homotrimer of polypeptides consisting of amino acids Glu 108 through Leu 261 of intact transmembrane CD154.
  • Graf et al (1995, Eur J Immunol 25:1749) describe another active fragment consisting of the C-terminal fragment produced by proteolyttic cleavage at Met 113.
  • Aruffo et al disclose soluble forms of CD154 and their use to stimulate B cells in vitro in U.S. Pat. No. 5,540,926.
  • particularly useful ligands for CD40 include polypeptides that comprise a sequence as set forth in SEQ ID NO. 2 of the '926 patent, from amino acid residues 47 to 261. These residues are comprised by the extracellular domain of human CD154.
  • Another particularly useful type of ligand for CD40 is an antibody to CD40.
  • antibodies include the monoclonal antibodies designated product numbers MCA1143 and MCA1590 of Harlan Bioproducts for Science (Indianapolis, Ind.); monoclonal antibodies designated catalog numbers P61640F (produced by clone 14G7), P42374M (produced by clone MAB89), P61046M (produced by clone BL-C4), and P54486M (produced by clone B-B20) of Biodesign International (Kennebunk, Me.); monoclonal antibody designated catalog number 05-422 (produced by clone 626.1) of Upstate Biotechnology (Lake Placid, N.Y.); monoclonal antibody designated catalog number 3601 (produced by clone S2C6) of Mabtech (Nacka, Sweden); monoclonal antibodies designated catalog numbers RDI-CBL486 (produced by clone BB20), RDI-M1691clb (
  • opsonin refers to naturally occurring and non-naturally occurring molecules which bind to both antigens and antigen presenting cells (APCs), such as, for example, phagocytic leukocytes (including monocytes and macrophages), dendritic cells (for example, Langerhans cells of the skin), B lymphocytes and, in humans, endothelial cells, or molecules which can be processed such that at least one product of the processing step or steps can bind to both antigens and antigen presenting cells (APCs), such as, for example, phagocytic leukocytes, dendritic cells, B lymphocytes, and, in humans, endothelial cells.
  • APCs antigen presenting cells
  • opsonin-enhanced cells provide a beneficial effect according to the invention because the opsonin portion acts as a link or coupling agent between the antigen and the APC to allow more efficient binding, engulfment, and internalization of the antigen.
  • the opsonin itself can be internalized with the antigen.
  • “Internalization” refers to the cellular uptake of a molecule such that it is brought into the cytoplasm or a compartment within the cytoplasm of the cell. Phagocytosis is a process by which a molecule is internalized by a cell.
  • Preferred opsonins are non-rodent opsonins, e.g., primate, e.g., human, opsonins.
  • Opsonins useful according to the invention bind to receptors on APCs (e.g., phagocytic leukocytes, e.g., macrophages and other cells of the phagocytic system) such as receptors on cells which play a role in innate immunity, as described herein.
  • Some sets of opsonins can be regarded as structurally and functionally similar.
  • one family comprises fragments of complement components C3 and C4. These two components are highly structurally homologous, and each possesses an intramolecular thiolester bond that is broken when a peptide (C3a or C4a respectively) is proteolytically cleaved from the native molecule. Disruption of the thiolester makes available a chemical structure that can form an ester linkage with an antigen.
  • the moiety of C3 on which this ester bond resides i.e. the non-C3a moiety, is designated C3b, and C4b is the analogous product of C4 cleavage.
  • C3b can be further proteolysed by proteins such as factor I to yield fragments such as C3bi and C3d, which also remain linked to the antigen via the ester bond.
  • CR1 is the major receptor for the C3b fragment of C3 and C4b fragment of C4. It is expressed on monocytes and monocyte-derived APCs, among other cell types.
  • CR2 is the major receptor for the fragment of C3 known as C3d, and is expressed on, e.g., mature B lymphocytes, but not on cells of monocytic lineage. The major role of CR2 on B lymphocytes is believed to be direct costimulation of B cells in concert with their cognate antigens.
  • CR3 is expressed primarily by neutrophils and monocytes and is also expressed on FDC, Kupffer cells, and NK cells.
  • CR3 is a C3 fragment receptor with a primary specificity for C3bi.
  • CR3 has been proposed as an important organizer of cytoskeletal events necessary for adhesive interactions and membrane reorganization during processes such as phagocytosis.
  • CR4 is a member of the beta2 integrin family, and its alpha chain is structurally similar to the alpha chain of CR3 and LFA-1. Its primary physiologic ligands are believed to be C3d and C3d,g;, however, its biologic activities are less well understood than CR3.
  • Another example of a family of innate opsonins is the collectins, a group of collagenous C-type lectins that comprises complement component C1q, mannose binding protein, surfactant proteins A and D, and conglutinin.
  • Each molecule comprises a lectin domain that can bind to an antigen, and a collagenous domain that can bind to receptors on phagocytic mononuclear cells, including receptors that are wholly or partially identical to the C1q receptor (Nepomuceno et al, Immunity 6:11'9-29; Tenner et al, Immunity 3:485-93; Guan et al, J Immunol 152:4005-16; Geertsma et al, Am J Physiol 267:L578-84; Miyamura et al, Biochem J 300:237-42; Malhotra et al, J Exp Med 172:955-9; Malhotra et al
  • collectins comprise multiple polypeptide chains, in some cases homomeric and in others heteromeric, that are assembled post-translationally, in part by covalent cross-linkage of hydroxyproline and hydroxylysine residues.
  • Collectins are demonstrated to be opsonins in, for example, Pikaar et al, J Infect Dis 172:481-9; Alvarez-Dominguez et al, Infection & Immunity 61:3664-72; Kuhlman et al, J Exp Med 169:1733-45; and Geertsma et al, op cit.
  • CRP C-reactive protein
  • alpha-2 macroglobulin a member of the pentraxin family of molecules, binds to receptors on cells of monocytic lineage and has been shown to be an opsonin (Tebo and Mortenson, J Immunol 144:231-8; Holzer et al, J Immunol 133:1424-30).
  • Alpha-2 macroglobulin like C3 and C4, comprises an internal thiolester bond that can be disrupted when the molecule is proteolysed.
  • Fibronectin binds to the alpha 5 beta 1 integrin and can also bind to various antigens, allowing it to function as an opsonin (Cosio, J Lab Clin Med 103:613-9; Czop and Austen, J Immunol 129:2678-81).
  • Immunoglobulins can function as opsonins by binding antigens via their variable regions and APCs via their constant regions.
  • an immunoglobulin comprises two heavy chains which are covalently bound to each other and each of which is bound to one light chain. These heterotetramers can further assemble into higher-order structures, such as the pentamers of IgM. Both heavy and light chain variable regions can contribute to the structure of the antigen binding site, whereas the APC binding site is located on the heavy chain constant region. Recombinant single-chain antibodies have also been described.
  • APC receptors for immunoglobulins include Fc alpha, Fc gamma, Fc epsilon, and Fc mu receptors for IgA, IgG, IgE, and IgM, respectively.
  • Opsonins that are naturally expressed by multicellular eukaryotic organisms are secreted. The latter characteristic distinguishes opsonins from adhesion molecules.
  • a non-naturally occurring molecule containing a naturally occurring APC-binding moiety shall be considered an opsonin if it contains a moiety through which it can be stably bound or attached to a cell such that the APC-binding moiety is located in the extracellular space, whether or not the molecule contains an antigen-binding moiety of a naturally occurring antigen.
  • Moieties through which molecules can be stably bound to a cell include crosslinking moieties, transmembrane sequences, and lipid moieties. The preparation of proteins containing these sequences or moieties is well-known to one of skill in the art.
  • An “APC binding moiety of an opsonin” is a sequence or domain of an opsonin which when included in a chimeric molecule permits binding of the chimeric molecule to a receptor that is physiologically expressed on an APC with an affinity at least in the nanomolar range.
  • opsonin fragments that comprise APC binding moieties.
  • Such a fragment may be any length so long as it retains an APC binding function; for example, it may be about 40 amino acids, 100 amino acids, 150 amino acids, 500 amino acids, 800 amino acids, or even as long as 3000 amino acids.
  • Las Holtet et al, 1994, FEBS Lett 344:242 describe a carboxy-terminal fragment of human ⁇ 2m (val1299-ala1451) that binds with high affinity to the ⁇ 2m receptor.
  • Fragments comprising amino acids 1314-1451 of human ⁇ 2m and the corresponding domain of rat ⁇ 2m also bind to ⁇ 2m receptors, albeit with 1-2% of the affinities of native ⁇ 2m (Van Leuven et al, 1986, J Biol Chem 261:11369; Enghild et al, 1989, Biochemistry 28:1406; Salvesen et al, 1992, FEBS Lett 313:198; Sottrup-Jensen et al, 1986, FEBS Lett 205:20).
  • An APC binding moiety of IgG comprises the CH2 domain and the lower hinge region, including residues 234-237, as described by Canfield and Morrison, 1991, J Exp Med 173:1483-91; Lund et al, 1991, J Immunol 147:2657-62; and Sarmay et al, 1992, Mol Immunol, 29:633-9.
  • opsonins which can be used in the compositions and methods of the invention include fibronectin (e.g., Genbank accessions X02761, K00799, K02273, X82402, X00307, X00739), CRP (e.g., Genbank accessions X17496, M11880, M11881, M11882), complement components such as C1q (e.g., Genbank accessions X66295, M22531, X03084, X58861, and Swiss-Prot accessions P02747, P02745), complement fragments such as C3b and C3d (e.g., Genbank accessions K02782, K02765), mannose binding protein (e.g., Genbank accessions S42292, S42294, X15422), conglutinin (e.g., Genbank accession X71774), alpha-2-macroglobulin (e.g., Genbank accessions M93264, M11313),
  • Exemplary Opsonin, APC binding moiety/APC receptor pairs useful according to the invention.
  • a given naturally occurring opsonin is considered useful according to the invention if it is determined to possess opsonicity according to one or more of the following assays, and if it is a secreted molecule.
  • SRBC bound via a physiologically occurring linkage to the candidate opsonin molecule are obtained.
  • APCs from the species to which the candidate opsonin is native are suspended at 4 ⁇ 10 6 /ml in ice-cold HBSS with 1% (w/v) Cohn fraction of BSA. If the candidate opsonin is a fragment of C3, the APCs are freshly drawn, uncultivated peripheral blood monocytes.
  • SRBC linked to the candidate opsonin or control SRBC are suspended in the same solution at 2 ⁇ 10 8 /ml.
  • 100 ul of SRBC suspension and 100 ul of APC suspension are mixed in a 10 ⁇ 75 mm plastic tube. The tube is rotated at 40 rpm at 37° C. for 2-20 min.
  • a small drop of the suspension is placed on a slide, covered with a coverslip, and allowed to stand for 5-10 min. Excess fluid can be removed by pressure on the coverslip, and the coverslip can be sealed to the slide, e.g. with clear nail polish.
  • the slide is examined microscopically, and the percentage of APCs visibly adherent to 4 or more SRBCs is determined. If the percentage is 50% or greater when there are up to 4 ⁇ 10 4 candidate opsonin molecules/SRBC′, the candidate opsonin can be an opsonin.
  • Candidate opsonin or radiolabeled Candidate opsonin is treated with a 1.5-3 fold molar excess of protease (0.05 M triethanolamine-0.1 M NaCl, pH 8.0, room temperature overnight).
  • protease 0.05 M triethanolamine-0.1 M NaCl, pH 8.0, room temperature overnight.
  • the protease can serve as the antigen or an excess of another antigen can be added.
  • the candidate opsonin-antigen complex is dialyzed against HBSS (4° C.).
  • Candidate opsonin-antigen complex binding to monocytes is measured by incubating labeled ligand at a concentration up to 1.0 M with (1.5-4.0) ⁇ 10 6 monocytes in 200 ml volume on ice. Nonspecific binding of radiolabeled ligands is determined in the presence of a 100-fold molar excess labeled candidate opsonin-antigen complex. The unbound ligand is separated from the cells and cell-bound ligand by rapid vacuum filtration on glass fiber filters. Studies are performed on ice to avoid potential complications due to endocytosis. Binding constarts and the number of sites per cell are determined by analysis and by nonlinear curve fit. If candidate opsonin-antigen complex affinity for a monocyte binding site is in at least the nanomolar range, the candidate opsonin is an opsonin.
  • P. carinii are isolated from bronchoaveolar lavage (BAL) of moribund infected rats using TBS with 1 mM calcium to preserve surface-bound candidate opsonin. Isolated organisms are fixed in periodate-lysine-paraformaldehyde buffer and embedded in Lowacryl mounting medium (Ted Pella, Inc., Redding, Calif.). Ultrathin sections are obtained, blocked with normal goat serum (2%) for 1 h, and incubated with either rabbit anti-candidate opsonin or nonimmune rabbit IgG (25 mg/ml) overnight.
  • BAL bronchoaveolar lavage
  • the sections are subsequently incubated with goat and rabbit IgG conjugated to 15 nM colloidal gold (Amersham Corp., Arlington Heights, Ill.). The sections are washed again and examined on a transmission electron microscope (model 6400:JEOL USA, Inc., Peabody, Mass.).
  • P. carinii The attachment of P. carinii to cultured alveolar macrophages in the presence or absence of antibody to the candidate opsonin or with the addition of purified candidate is quantified as follows. Adherence of P. carinii to alveolar macrophages is assayed by 51 Cr-labeling the organisms. P. carinii are isolated from infected rats with TBS containing 1 mM calcium to prevent loss of surface-bound candidate opsonin. The organisms are radiolabeled by incubation for 8 h at 37° C. in 2 ml of DME containing 20% FCS and 200 mCi of 51 Cr-sodium chromate (New England Nuclear).
  • Normal alveolar macrophages are lavaged from healthy rats and plated in tissue culture plates (1 ⁇ 10 5 ) cells/well) which are been precoated with normal rat IgG (100 mg/ml ⁇ 60 min) in order to ensure firm adherence of the macrophages. After 1 h, the macrophages are gently washed with HBSS to remove nonadherent cells. >95% of macrophages are adherent after this wash. 51 Cr- P. carinii (1 ⁇ 10 6 ) containing surface-associated candidate opsonin are added to the macrophages and incubated at 37° C. for an additional hour. Subsequently, nonadherent P. carinii are removed by washing.
  • the macrophage monolayers containing adherent P. carinii are solubilized in 1 N NaOH and quantified.
  • P. carinii adherence assays are conducted in the presence or absence of a polyclonal rabbit antibody generated against the candidate opsonin (100 mg/ml).
  • candidate opsonin binding to P. carinii is apparent in Part I and if, in Part II, % adherence is diminished in the presence of anti-candidate opsonin with statistical significance of P ⁇ 0.05, the candidate opsonin is an opsonin.
  • the nonadherent bacteria are removed by five washes with warm PBS. Assays are performed in quadruplicate; in each well, the number of bacteria associated with 3 100 monocytes is counted under a flourescence microscope using ⁇ 400 magnification. Results are expressed as the number of bacteria associated with 100 monocytes. If this number with candidate opsonin can be at least twice that without candidate opsonin, the candidate opsonin is an opsonin.
  • APCs are plated in 96-well tissue culture plates (Costar, Cambridge, Mass.) at 2 ⁇ 10 5 cells per ml the evening before use. 2 ⁇ 10 6 bacteria per well (0.1 ml per well) are added to the culture plates with or without 100 mcg/ml of candidate opsonin. The plates are then centrifuged at 1,000 ⁇ g for 7 min. After 15 min at 37° C. to allow the uptake of bacteria, free bacteria are removed by several washes with cold PBS. They are then incubated (45 min, 37° C.) in RPMI 1640 plus an amount of antibiotic that, when present in the culture for 45 min, kills all extracellular bacteria. The end of this incubation period is considered time zero.
  • Monolayers are washed three times with Hanks' balanced saline solution, and the same volume of RPMI 1640 (R0) is added.
  • the cells are lysed by using several cycles of freezing and thawing.
  • the number (CFU) of viable bacteria per well is determined by quantitative plate counts on blood agar plates (Columbia blood agar; Becton Dickinson, San Jose, Calif.) after 24 h of incubation. Each result is given as the mean of three determinations.
  • candidate opsonin-treated bacterial pellet has >75 KCPM and this incorporation can be inhibited by unlabeled candidate opsonin, and if in Part II the CFU with candidate opsonin is greater than without (P ⁇ 0.05), the candidate opsonin can be an opsonin.
  • GHBSS Human Brain Culture Collection
  • gelatin containing 10 m mol CaCl 2
  • Binding assays are done in the presence or absence of a competitive inhibitor. After incubation for 30 minutes, the bacteria are washed five times in a GHBSS+10 mmol CaCl 2 at room temperature in a microfuge at 1,300 g for 3 minutes.
  • radiolabeled bacteria are resuspended in 200 ⁇ l of GHBSS+10 mmol CaCl 2 and are incubated with or without candidate opsonin ranging from 2 ⁇ g/ml to 40 ⁇ g/ml at 4° C. for 30 min.
  • the bacteria are then washed three times in GHBSS+10 mmol CaCl 2 for 3 min at room temperature in a microfuge at 1,300 g, resuspended in 50 ⁇ l of GHBSS and added to a 1-ml suspension containing on the order of 10 6 APCs (GHBSS).
  • the bacteria and APCs are gently rocked at 37° C.
  • the candidate opsonin can be an opsonin.
  • APCs are plated out at 1 ⁇ 10 6 cells/well on glass coverslips in a 24-well tissue culture plate.
  • Cells are incubated in RPMI 1640 (Life Technologies) supplemented with 10% PCS, 1 mM glutamine, 200 U/ml penicillin and 200 ⁇ g/ml streptomycin in a humidified incubator at 37° C. After 24 h, nonadherent cells are removed and remaining cells are used after 6 days.
  • Promastigotes are incubated with or without candidate at 30 ⁇ g/ml in RPMI 1640 for 1 h and then washed three times before adding to the APC cultures at 10 6 /well.
  • Promastigotes are allowed to infect APCs for 1 h, then cells are washed, fixed with methanol, and Geimsa stained (BDH, Poole, Dorset, U.K.) before counting. The percentage of APCs infected and the number of parasites/100 macrophages is determined from quadruplicate cultures.
  • the affinity of candidate opsonin for parasites is at least in the nanomolar range and in Part II the number of parasites taken up/100 APCs is, with candidate opsonin, at least twice that without candidate opsonin, the candidate opsonin can be an opsonin.
  • Portions (0.5 ml) of [ 35 S] methionine-labeled culture medium containing 5 percent fetal calf serum and the candidate opsonin are incubated for 30 minutes at room temperature with 0.1 ml or 0.2 ml of a 10 percent suspension of a microorganism).
  • the microorganisms tested may include, for example, Salmonella typhimurium, Bacillus subtilis, Staphylococcus aureus, Escherichia coli , and Saccharomyces cerevisiae . Bound proteins are released by boiling in buffer containing 2 percent SDS and 0.1 M dithiothreitol and are analyzed on a 5 percent SDS gel.
  • the candidate opsonin can be an opsonin.
  • a candidate opsonin that satisfies Part II of an assay can be an opsonin if it can bind to the antigen of the assay with an affinity in at least the nanomolar range.
  • SRBC coated with at least 1.2 ⁇ 10 4 molecules/cell of a fragment of C3 are prepared as described by O'Rear and Ross in Current Protocols in Immunology, 1994, John Wiley & Sons, pp. 13.4.5-9.
  • 250 ul of monocytes at 2 ⁇ 10 5 cells/ml of RPMI with 10% fetal calf serum are added to each well of an 8-well glass tissue culture plate and incubated at 37° C., 5% CO 2 for 3 h.
  • the monocytes are washed twice with HBSS, and 50 ul of the SRBC at 1.5 ⁇ 10 8 /ml of DVBS 2+ are added to each well.
  • the plate is centrifuged at 50 g for 5 min and then incubated at 37° C., 5% CO 2 for 3 h.
  • the walls are washed twice with HBSS, fixed with 0.5% glutaraldehyde, and stained with Giemsa stain. If >40% of the monocytes form rosettes with at least 1 SRBC as determined by light microscopy, the candidate can be an opsonin.
  • HSPs Heat shock proteins
  • HSP-peptide complexes have been described as being useful in vaccines against cancers and infectious diseases by Srivastava et al., “Heat shock protein-peptide complexes in cancer immunotherapy” in Current Opinion in Immunology (1994), 6:728-732; Srivastava, “Peptide-Binding Heat Shock Proteins in the Endoplasmic Reticulum” in Advances in Cancer Research (1993), 62:153-177.
  • the HSP-peptide complexes appear to work as vaccines, because they may function as antigen carrying and presentation molecules.
  • HSPs appear to be part of the process by which peptides are transported to the Major Histocompatibility Complex (MHC) molecules for surface presentation.
  • MHC Major Histocompatibility Complex
  • HSPs have been shown to exhibit immunogenicity, and are useful in the present invention, including, but not limited to: gp96, hsp90, hsp100, hsp60, hsp 25 and hsp70, see Udono et al., supra.
  • Heat shock proteins may be purified for use in the present invention using a procedure employing DE52 ionexchange chromatography followed by affinity chromatography on ATP-agarose, see Welch et al., “Rapid Purification of Mammalian 70,000-Dalton Stress Proteins: Affinity of the Proteins for Nucleotides” in Molecular and Cellular Biology (June 1985), 1229-1237.
  • Adhesion molecules useful in the present invention include any cell-surface protein which is involved in bediating the recognition and adhesion of cell sto their substrate and to other cells.
  • Cellular adhesion molecules can be divided into two primary classes: Ca 2+ dependent (cadherins) and Ca 2+ independent.
  • cadherins There are over a dozen different types of Ca 2+ dependent adhesion molecules called cadherins. Most cadherins are single-pass transmembrane glycoproteins composed of about 700-750 amino acid residues. The large extracellular part of the molecule is usually folded into five domains, each containing about 100 amino acid residues. Four of these domains contain presumptive Ca 2+ binding sites. Cadherins are often present in the cell membrane as dimers.
  • Cadherens useful in the present invention include, but are not limited to cadherin E, cadherin N, cadherin BR, cadherin P, cadherin R, cadherin M, cadherin VE, cadherin T&H, cadherin OB, cadherin K, cadherin 7, cadherin 8, cadherin KSP, cadherin LI, cadherin 18, fibroblast 1, cadherin, fibroblast 2, cadherin, fibroblast 3, cadherin 23, desmocollin 1, desmocollin 2, desmoglein 1, desmoglein 2, desmoglein 3, and protocadherin 1, 2, 3, 7, 8, and 9.
  • adhesion molecules are Ca 2+ independent, and, like the cadherins, may be used as ligands of a cell surface protein on an APC in the present invention.
  • General classes of adhesion molecules as well as specific adhesion molecules useful in the present invention are shown below in Table 3.
  • the portion of the multifunctional molecule which is a ligand of a cell surface protein of an APC is a defensin.
  • Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic, polar peptides (30-35 aa, 3-4 kDa), are distinguished by a conserved tri-disulfide and largely beta sheet structure. When expressed at the cell surface, defensins have been hypothesized to function as a biocheical barrier against microbial invection by inhibiting colonization of the epithelium by a wide range of pathogenic microorganisms. Defensins useful in the present invention include, but are not limited to human alpha defensins 1-6, human neutrophil peptides 1-4, human beta defensin 1 and 2, and rat beta defeinsin 1 and 2.
  • the portion of the multifunctional molecule which is a ligand of a cell surface protein of an APC is a counter-receptor of a T cell co-stimulatory molecule.
  • Costimulation is defined as a signaling pathway that does more than simply augment antigen receptor-proximal activation events, but that intersects with antigen-specific signals synergistically to allow lymphocyte activation.
  • a counter-receptor of a co-stimulatory molecule, useful in the present invention includes, but is not limited to a receptor for one or more of B7-1, B7-2, ICOS:B7h, PD-1:PD-L1/PD-L2, CD48, CD40 ligand, and OX40.
  • Counter-receptors useful in the present invention include, but are not limited to CD28, CTLA-4, ICOS, PD-1, members of the TNF receptor family, CD40, the major B cell costimulatory molecule, as well as OX-40, 4-1BB, CD30, and CD27.
  • the multifunctional molecule is a fusion polypeptide which comprises one or more amino acids interposed between the first and second parts which bind to cells, e.g. a fusion polypeptide which comprises a first amino acid sequence which can bind to an antigen bearing target and a second amino acid sequence which can bind to a leukocyte, and which further comprises at least one amino acid interposed between the first and second parts.
  • the interposed amino acids may comprise, e.g., a linker sequence intended to lessen steric hindrance or other undesirable interactions between the aforementioned first and second parts.
  • one such type of sequence takes the form (Gly x Ser) n , wherein n is an integer from between 1 and 15, and x is an integer betewen 1 and 10.
  • Additional useful linkers include, but are not limited to (Arg-Ala-Arg-Asp-Pro-Arg-Val-Pro-Val-Ala-Thr) 1-5 (Xu et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96: 151-156), (Gly-Ser), (Shao et al., 2000, Bioconjug. Chem. 11: 822-826), (Thr-Ser-Pro) n (Kroon et al., 2000, Eur. J. Biochem.
  • viral antigens include, but are not limited to, retroviral antigens such as retroviral antigens from the human immunodeficiency virus (HIV) antigens such as gene products of the gag, pol, and env genes, the Nef protein, reverse transcriptase, and other HIV components; hepatitis viral antigens such as the S. M, and L proteins of hepatitis B virus, the pre-S antigen of hepatitis B virus, and other hepatitis, e.g., hepatitis A, B.
  • retroviral antigens such as retroviral antigens from the human immunodeficiency virus (HIV) antigens such as gene products of the gag, pol, and env genes, the Nef protein, reverse transcriptase, and other HIV components
  • hepatitis viral antigens such as the S. M, and L proteins of hepatitis B virus, the pre-S antigen of hepatitis B virus, and other he
  • viral components such as hepatitis C viral RNA; influenza viral antigens such as hemagglutinin and neuraminidase and other influenza viral components; measles viral antigens such as the measles virus fusion protein and other measles virus components; rubella viral antigens such as proteins E1 and E2 and other rubella virus components; rotaviral antigens such as VP7sc and other rotaviral components; cytomegaloviral antigens such as envelope glycoprotein B and other cytomegaloviral antigen components; respiratory syncytial viral antigens such as the RSV fusion protein, the M2 protein and other respiratory syncytial viral antigen components; herpes simplex viral antigens such as immediate early proteins, glycoprotein D, and other herpes simplex viral antigen components; varicella zoster viral antigens such as gpI, gpII, and other varicella zoster viral antigen components; Japanese encephalitis viral antigens
  • Bacterial antigens which can be used in the compositions and methods of the invention include, but are not limited to, pertussis bacterial antigens such as pertussis toxin, filamentous hemagglutinin, pertactin, FIM2, FIM3, adenylate cyclase and other pertussis bacterial antigen components; diptheria bacterial antigens such as diptheria toxin or toxoid and other diphtheria bacterial antigen components; tetanus bacterial antigens such as tetanus toxin or toxoid and other tetanus bacterial antigen components; streptococcal bacterial antigens such as M proteins and other streptococcal bacterial antigen components; grarn-negative bacilli bacterial antigens such as lipopolysaccharides and other gram-negative bacterial antigen components; Mycobacterium tuberculosis bacterial antigens such as mycolic acid, heat
  • Fungal antigens which can be used in the compositions and methods of the invention include, but are not limited to, candida fungal antigen components; histoplasma fungal antigens such as heat shock protein 60 (HSP60) and other histoplasma fungal antigen components; cryptococcal fungal antigens such as capsular polysaccharides and other cryptococcal fungal antigen components; coccidiodes fungal antigens such as spherule antigens and other coccidiodes fungal antigen components; and tinea fungal antigens such as trichophytin and other coccidiodes fungal antigen components.
  • candida fungal antigen components histoplasma fungal antigens such as heat shock protein 60 (HSP60) and other histoplasma fungal antigen components
  • cryptococcal fungal antigens such as capsular polysaccharides and other cryptococcal fungal antigen components
  • coccidiodes fungal antigens such as spherule antigens and other
  • protozoa and other parasitic antigens include, but are not limited to, plasmodium falciparum antigens such as merozoite surface antigens, sporozoite surface antigens, circumsporozoite antigens, gametocyte/gamete surface antigens, blood-stage antigen pf 1 55/RESA and other plasmodial antigen components; toxoplasma antigens such as SAG-1, p30 and other toxoplasma antigen components; schistosomae antigens such as glutathione-S-transferase, paramyosin, and other schistosomal antigen components; leishmania major and other leishmaniae antigens such as gp63, lipophosphoglycan and its associated protein and other leishmanial antigen components; and trypanosoma cruzi antigens such as the 75-77 kDa antigen, the 56 kDa antigen and other trypanosomal antigen components.
  • Tumor antigens which can be used in the compositions and methods of the invention include, but are not limited to, telomerase components; multidrug resistance proteins such as P-glycoprotein; MAGE-1, alpha fetoprotein, carcinoembryonic antigen, mutant p53, immunoglobulins of B-cell derived malignancies, fusion polypeptides expressed from genes that have been juxtaposed by chromosomal translocations, human chorionic gonadotrpin, calcitonin, tyrosinase, papillomavirus antigens, gangliosides or other carbohydrate-containing components of melanoma or other tumor cells. It is contemplated by the invention that antigens from any type of tumor cell can be used in the compositions and methods described herein.
  • Antigens involved in autoimmune diseases, allergy, and graft rejection can be used in the compositions and methods of the invention.
  • an antigen involved in any one or more of the following autoimmune diseases or disorders can be used in the present invention: diabetes mellitus, arthritis (including rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, psoriatic arthritis), multiple sclerosis, myasthenia gravis, systemic lupus erythematosis, autoimmune thyroiditis, dermatitis (including atopic dermatitis and eczematous dermatitis), psoriasis, Sjogren's Syndrome, including keratoconjunctivitis sicca secondary to Sjogren's Syndrome, alopecia areata, allergic responses due to arthropod bite reactions, Crohn's disease, aphthous ulcer, ulceris, conjunctivitis, keratoconjunctivitis, ulcerative colitis, asthma, allergic
  • antigens involved in autoimmune disease include glutamic acid decarboxylase 65 (GAD 65), native DNA, myelin basic protein, myelin proteolipid protein, acetylcholine receptor components, thyroglobulin, and the thyroid stimulating hormone (TSH) reception.
  • GID 65 glutamic acid decarboxylase 65
  • native DNA myelin basic protein
  • myelin proteolipid protein acetylcholine receptor components
  • thyroglobulin thyroid stimulating hormone
  • antigens involved in allergy include pollen antigens such as Japanese cedar pollen antigens, ragweed pollen antigens, rye grass pollen antigens, animal derived antigens such as dust mite antigens and feline antigens, histocompatiblity antigens, and penicillin and other therapeutic drugs.
  • antigens involved in graft rejection include antigenic components of the graft to be transplanted into the graft recipient such as heart, lung, liver, pancreas, kidney, and neural graft components.
  • An antigen can also be an altered peptide ligand useful in treating an autoimmune disease.
  • miscellaneous antigens which can be can be used in the compositions and methods of the invention include endogenous hormones such as luteinizing hormone, follicular stimulating hormone, testosterone, growth hormone, prolactin, and other hormones, drugs of addiction such as cocaine and heroin, and idiotypic fragments of antigen receptors such as Fab-containing portions of an anti-leptin receptor antibody.
  • endogenous hormones such as luteinizing hormone, follicular stimulating hormone, testosterone, growth hormone, prolactin, and other hormones
  • drugs of addiction such as cocaine and heroin
  • idiotypic fragments of antigen receptors such as Fab-containing portions of an anti-leptin receptor antibody.
  • the association between the multifunctional molecule and an antigen bearing target and/or an APC may be measured for example by Fluorescent Resonance Energy Transfer (FRET), wherein one peptide (i.e., the multifunctional molecule) comprises a fluorescent label moiety, and the antigen bearing target or APC harbours a second such moiety, and where excitation at an appropriate wavelength may result in absorption of photons by one label, followed by FRET, and emission at a second wavelength characteristic of the second fluorophore, this emission being measured and corresponding to the amount of antigen bearing target or APC which is associated with the multifunctional molecule.
  • FRET Fluorescent Resonance Energy Transfer
  • this association may be measured in one of many other ways which are described more fully below.
  • fluorescent tag or “fluorescent group” refers to either a fluorophore or a fluorescent protein or fluorescent fragment thereof, or refers to a fluorescent amino acid such as tryptophan which may be incorporated into a polypeptide.
  • fluorescent protein refers to any protein which fluoresces when excited with appropriate electromagnetic radiation. This includes proteins whose amino acid sequences are either natural or engineered.
  • the fluorophores comprise fluorescein and tetramethylrhodamine or another suitable pair.
  • the label comprises two different fluorescent proteins. It is preferred that fluorescent proteins comprise any protein selected from the group consisting of green fluorescent protein (GFP), blue fluorescent protein, red fluorescent protein and other engineered forms of GFP.
  • GFP green fluorescent protein
  • the polypeptide comprises a cysteine amino acid through which the label is attached via a covalent bond.
  • the label may be attached via a primary amine group such as via a lysine residue.
  • the polypeptide is immobilised via cysteine residues, the label is advantageously attached via lysine residues.
  • the measuring is performed by fluorescent resonance energy transfer (FRET), fluorescence anisotropy or fluorescence correlation spectroscopy, or by measuring the binding of a fluorescent partner polypeptide to an immobilised polypeptide.
  • FRET fluorescent resonance energy transfer
  • fluorescence anisotropy fluorescence correlation spectroscopy
  • the fluorescence emitting means comprise two different fluorophores, and particularly preferred that the fluorophores comprise fluorescein and tetramethylrhodamine or another suitable pair.
  • the term “appropriate combination” refers to a choice of reporter labels such that the emission wavelength spectrum of one (the “donor” moiety) is within the excitation wavelength spectrum of the other (the “acceptor” moiety).
  • Methods of detection without use of label are known in the art. These include detection using surface plasmon resonance to detect changes in the mass of, for example the multifunctional molecule, which would occur if binding of the partner polypeptide increased or decreased. Such measurements may be made for example using a BIACORE machine.
  • the multifunctional molecule is immobilized on a solid support prior to contacting the molecule with the antigen bearing moiety and/or APC.
  • one technique for determing the binding of a multifunctional molecule of the invention to an antigen bearing moiety and/or and APC involves the use of antibodies specifically directed to the multifunctional molecule.
  • antigen bearing cells for example, are incubated with the multifunctional molecule of the invention in RPMI 1640, or other suitable buffer, for 1-4 hours at 37° C. with shaking. The cells are then washed in PBS containing 2% FBS, or other cell culture serum. The antigen bearing cells are then incubated with, for example, an FITC labeled anti-multifunctional molecule antibody for 1 hour at 4° C. After additional washing in PBS, the cells are analyzed by flow cytometry, wherein the identification of labeled cells is indicative of the binding of the multifunctional molecule of the invention to the antigen bearing cell.
  • a nucleic acid molecule encoding a multifunctional molecule of the present invention is introduced into a host cell capable of expressing the nucleic acid molecule so as to produce the multifunctional molecule.
  • the host cell is permitted to express the nucleic acid ex vivo.
  • the host cell is transfected with the nucleic acid molecule encoding the multifunctional molecule, and then placed back into the host animal from which it was obtained, wherein the multifunctional polypeptide molecule is expressed in vivo in the host animal.
  • Host cells are transfected, as taught herein, via conventional methods well-known in the art. Suitable methods for transforming or transfecting host cells can be found in Sambrook et al. ( Molecular Cloning: A Laboratory Manual, 2nd Edition, Cold Spring Harbor Laboratory press (1989)), and other laboratory manuals. Additional examples of methods of introducing nucleic acid molecules encoding multifunctional molecules are described below.
  • the cells containing the introduced nucleic acid molecules encoding, for example, multifunctional molecule and/or an antigen can themselves be administered to a subject (as the antigen) according to the methods of the invention, e.g., in a vaccine composition.
  • Transfection mediated by DEAE-dextran Naked nucleic acid can be introduced into cells by forming a mixture of the nucleic acid and DEAE-dextran and incubating the mixture with the cells. A dimethylsulfoxide or chloroquine shock step can be added to increase the amount of nucleic acid uptake.
  • DEAE-dextran transfection is only applicable to in vitro modification of cells and can be used to introduce nucleic acid transiently into cells but is not preferred for creating stably transfected cells. Thus, this method can be used for short term production of a gene product but is not a method of choice for long-term production of a gene product.
  • Electroporation Naked nucleic acid can also be introduced into cells by incubating the cells and the nucleic acid together in an appropriate buffer and subjecting the cells to a high-voltage electric pulse.
  • the efficiency with which nucleic acid is introduced into cells by electroporation is influenced by the strength of the applied field, the length of the electric pulse, the temperature, the conformation and concentration of the nucleic acid and the ionic composition of the media.
  • Electroporation can be used to stably (or transiently) transfect a wide variety of cell types and is only applicable to in vitro modification of cells. Protocols for electroporating cells can be found in Current Protocols in Molecular Biology , Ausubel, F. M. et al. (e's.) Greene Publishing Associates, (1989), Section 9.3 and in Molecular Cloning: A Laboratory Manual, 2nd Edition, Sambrook et al. Cold Spring Harbor Laboratory Press, (1989), Sections 16.54-16.55 or other standard laboratory manuals.
  • Liposome-mediated transfection Naked nucleic acid can be introduced into cells by mixing the nucleic acid with a liposome suspension containing cationic lipids. The nucleic acid/liposome complex is then incubated with cells. Liposome mediated transfection can be used to stably (or transiently) transfect cells in culture in vitro. Protocols can be found in Current Protocols in Molecular Biology , Ausubel, F. M. et al. (e's.) Greene Publishing Associates, (1989), Section 9.4 and other standard laboratory manuals. Additionally, gene delivery in vivo has been accomplished using liposomes. See for example Nicolau et al. (1987) Meth. Enz.
  • nucleic acid can be introduced into cells by directly injecting the nucleic acid into the cells.
  • nucleic acid can be introduced by microinjection. Since each cell is microinjected individually, this approach is very labor intensive when modifying large numbers of cells.
  • microinjection is a method of choice is in the production of transgenic animals (discussed in greater detail below). In this situation, the nucleic acid is stably introduced into a fertilized oocyte which is then allowed to develop into an animal. The resultant animal contains cells carrying the nucleic acid introduced into the oocyte.
  • Direct injection has also been used to introduce naked nucleic acid into cells in vivo (see e.g., Acsadi et al. (1991) Nature 332: 815-818; Wolff et al. (1990) Science 247:1465-1468).
  • a delivery apparatus e.g., a “gene gun” for injecting DNA into cells in vivo can be used.
  • Such an apparatus is commercially available (e.g., from BioRad).
  • Naked nucleic acid can also be introduced into cells by complexing the nucleic acid to a cation, such as polylysine, which is coupled to a ligand for a cell-surface receptor (see for example Wu, G. and Wu, C. H. (1988) J. Biol. Chem 263:14621; Wilson et al. (1992) J. Biol. Chem. 267:963-967; and U.S. Pat. No. 5,166,320). Binding of the nucleic acid-ligand complex to the receptor facilitates uptake of the nucleic acid by receptor-mediated endocytosis.
  • a cation such as polylysine
  • Receptors to which a nucleic acid-ligand complex have targeted include the transferrin receptor and the asialoglycoprotein receptor.
  • a nucleic acid-ligand complex linked to adenovirus capsids which naturally disrupt endosomes, thereby releasing material into the cytoplasm can be used to avoid degradation of the complex by intracellular lysosomes (see for example Curiel et al. (1991) Proc. Natl. Acad. Sci. USA 88:8850; Cristiano et al. (1993) Proc. Natl. Acad. Sci USA 90:2122-2126).
  • Receptor-mediated nucleic acid uptake can be used to introduce nucleic acid into cells either in vitro or in vivo and, additionally, has the added feature that nucleic acid can be selectively targeted to a particular cell type by use of a ligand which binds to a receptor selectively expressed on a target cell of interest.
  • nucleic acid when naked nucleic acid is introduced into cells in culture (e.g., by one of the transfection techniques described above) only a small fraction of cells (about 1 out of 105) typically integrate the transfected nucleic acid into their genomes (i.e., the nucleic acid is maintained in the cell episomally).
  • a selectable marker in order to identify cells which have taken up exogenous nucleic acid, it is advantageous to transfect nucleic acid encoding a selectable marker into the cell along with the nucleic acid(s) of interest.
  • selectable markers include those which confer resistance to drugs such as G418, hygromycin and methotrexate.
  • a selectable marker maybe one which emits a detectable signal upon expression such as green fluorescen protein or blue fluorescent protein.
  • Selectable markers may be introduced on the same plasmid as the gene(s) of interest or may be introduced on a separate plasmid.
  • a preferred approach for introducing nucleic acid encoding a gene product into a cell is by use of a viral vector containing nucleic acid, e.g. a cDNA, encoding the gene product.
  • a viral vector containing nucleic acid e.g. a cDNA
  • Infection of cells with a viral vector has the advantage that a large proportion of cells receive the nucleic acid, which can obviate the need for selection of cells which have received the nucleic acid.
  • molecules encoded within the viral vector e.g., by a cDNA contained in the viral vector, are expressed efficiently in cells which have taken up viral vector nucleic acid and viral vector systems can be used either in vitro or in vivo.
  • Retroviruses Defective retroviruses are well characterized for use in gene transfer for gene therapy purposes (for a review see Miller, A. D. (1990) Blood 76:271).
  • a recombinant retrovirus can be constructed having a nucleic acid encoding a gene product of interest inserted into the retroviral genome. Additionally, portions of the retroviral genome can be removed to render the retrovirus replication defective. The replication defective retrovirus is then packaged into virions which can be used to infect a target cell through the use of a helper virus by standard techniques. Protocols for producing recombinant retroviruses and for infecting cells in vitro or in vivo with such viruses can be found in Current Protocols in Molecular Biology , Ausubel, F. M.
  • retroviruses examples include pLJ, pZIP, pWE and pEM which are well known to those skilled in the art.
  • suitable packaging virus lines include ⁇ Crip, ⁇ Cre, — 2, and_Am. Retroviruses have been used to introduce a variety of genes into many different cell types, including epithelial cells, endothelial cells, lymphocytes, myoblasts, hepatocytes, bone marrow cells, in vitro and/or in vivo (see for example Eglitis, et al.
  • Retroviral vectors require target cell division in order for the retroviral genome (and foreign nucleic acid inserted into it) to be integrated into the host genome to stably introduce nucleic acid into the cell. Thus, it may be necessary to stimulate replication of the target cell.
  • Adenoviruses The genome of an adenovirus can be manipulated such that it encodes and expresses a gene product of interest but is inactivated in terms of its ability to replicate in a normal lytic viral life cycle. See for example Berkner et al. (1988) BioTechniques 6:616; Rosenfeld et al. (1991) Science 252:431-434; and Rosenfeld et al. (1992) Cell 68:143-155.
  • Suitable adenoviral vectors derived from the adenovirus strain Ad type 5 d1324 or other strains of adenovirus are well known to those skilled in the art.
  • Recombinant adenoviruses are advantageous in that they do not require dividing cells to be effective gene delivery vehicles and can be used to infect a wide variety of cell types, including airway epithelium (Rosenfeld et al. (1992) cited supra), endothelial cells (Lemarchand et al. (1992) Proc. Natl. Acad. Sci. USA 89:6482-6486), hepatocytes (Herz and Gerard (1993) Proc. Natl. Acad. Sci. USA 90:2812-2816) and muscle cells (Quantin et al. (1992) Proc. Natl. Acad. Sci. USA 89:2581-2584).
  • introduced adenoviral nucleic acid (and foreign DNA contained therein) is not integrated into the genome of a host cell but remains episomal, thereby avoiding potential problems that can occur as a result of insertional mutagenesis in situations where introduced nucleic acid becomes integrated into the host genome (e.g., retroviral DNA).
  • the carrying capacity of the adenoviral genome for foreign DNA is large (up to 8 kilobases) relative to other gene delivery vectors (Berkner et al. cited supra; Haj-Ahmand and Graham (1986) J. Virol. 57:267).
  • Most replication-defective adenoviral vectors currently in use are deleted for all or parts of the viral E1 and E3 genes but retain as much as 80% of the adenoviral genetic material.
  • Adeno-associated virus is a naturally occurring defective virus that requires another virus, such as an adenovirus or a herpes virus, as a helper virus for efficient replication and a productive life cycle.
  • AAV Adeno-associated virus
  • It is also one of the few viruses that may integrate its DNA into non-dividing cells, and exhibits a high frequency of stable integration (see for example Flotte et al. (1992) Am. J. Respir. Cell. Mol. Biol. 7:349-356; Samulski et al. (1989) J. Virol.
  • Vectors containing as little as 300 base pairs of AAV can be packaged and can integrate. Space for exogenous nucleic acid is limited to about 4.5 kb.
  • An AAV vector such as that described in Tratschin et al. (1985) Mol. Cell. Biol. 5:3251-3260 can be used to introduce nucleic acid into cells.
  • a variety of nucleic acids have been introduced into different cell types using AAV vectors (see for example Hermonat et al. (1984) Proc. Natl. Acad. Sci. USA 81 :6466-6470; Tratschin et al. (1985) Mol. Cell. Biol.
  • nucleic acid introduced into a cell can be detected by a filter hybridization technique (e.g., Southern blotting) and RNA produced by transcription of introduced nucleic acid can be detected, for example, by Northern blotting, RNase protection or reverse transcriptase-polymerase chain reaction (RI-PCR).
  • RI-PCR reverse transcriptase-polymerase chain reaction
  • the gene product can be detected by an appropriate assay, for example by immunological detection of a produced protein, such as with a specific antibody, or by a functional assay to detect a functional activity of the gene product, such as an enzymatic assay.
  • an expression system can first be optimized using a reporter gene linked to the regulatory elements and vector to be used.
  • the reporter gene encodes a gene product which is easily detectable and, thus, can be used to evaluate the efficacy of the system.
  • Standard reporter genes used in the art include genes encoding beta-galactosidase, chloramphenicol acetyl transferase, luciferase and human growth hormone.
  • the invention provides for host cells transfected with nucleic acid constructs encoding a multifunctional molecule of the invention.
  • Host cells useful in the invention include but are not limited to the following.
  • a host cell can be any cell which is able to act as a carrier for an antigen according to the invention and thus may be a nucleated cell or a procaryotic cell into which nucleic acid can be artificially introduced.
  • Procaryotic cells useful according to the invention include bacterial cells.
  • Eucaryotic (nucleated) cells useful according to the invention include cells of a yeast, fungus, cells of a parasite and mammalian cells.
  • Mammalian cells useful according to the invention include but are not limited to fibroblasts, including specialized mesenchymal cells such as a synoviocytes; keratinocytes, epithelial cells, endothelial cells, leukocytes and tumor cells.
  • Cell lines useful according to the invention include but are not limited to B16, CMS-5 fibrosarcoma cells, Cos1 cells and CHO cells, TS/A, Lewis lung carcinoma, RENCA, Dunning rat prostate carcinoma, and cell lines included in the catalogue of the American Type Culture Collection (Manassas, Va.).
  • Host cells comprising a nucleic acid molecule encoding a multifunctional molecule of the invention can be prepared from pathogenic cells according to the invention.
  • Pathogenic cells include tumor cells (e.g. B16 cells, CMS-5 fibrosarcoma cells, and cells derived from the tumors included in the section entitled “Tumors for which the Invention is Useful”), and cells derived from pathogenic bacterium, pathogenic fungus, pathogenic virus, pathogenic parasite, or a pathogenic arthropod.
  • the invention provides for methods of detecting a protein (e.g., a multifunctional molecule) that is expressed from a recombinant nucleic acid molecule that has been artificially introduced into a cell.
  • a protein e.g., a multifunctional molecule
  • Antibodies specific for a protein useful according to the invention are useful for protein purification, and for the detection of expression of these proteins from cells into which a recombinant nucleic acid molecule expressing these proteins has been artificially introduced.
  • a protein useful according to the invention e.g., a multifunctional molecule
  • an antibody useful in the invention may comprise a whole antibody, an antibody fragment, a polyfunctional antibody aggregate, or in general a substance comprising one or more specific binding sites from an antibody.
  • the antibody fragment may be a fragment such as an Fv, Fab or F(ab′) 2 fragment or a derivative thereof, such as a single chain Fv fragment.
  • the antibody or antibody fragment may be non-recombinant, recombinant or humanized.
  • the antibody may be of an immunoglobulin isotype, e.g., IgG, IgM, and so forth.
  • an aggregate, polymer, derivative and conjugate of an immunoglobulin or a fragment thereof can be used where appropriate.
  • a protein product (or fragment or oligopeptide thereof) of a protein according to the invention e.g., a multifunctional molecule according to the invention
  • Antibodies may be directed to any portion of the multifunctional molecule of the invention.
  • an antibody may be directed to the lecting portion of the multifunctional molecule or to the ligand portion of the multifunctional molecule.
  • Peptides used to induce specific antibodies may have an amino acid sequence consisting of at least five amino acids and preferably at least 10 amino acids. Preferably, they should be identical to a region of the natural protein and may contain the entire amino acid sequence of a small, naturally occurring molecule.
  • Short stretches of amino acids corresponding to the protein product of a recombinant nucleic acid encoding a protein useful according to the invention may be fused with amino acids from another protein such as keyhole limpet hemocyanin or GST, and antibody will be produced against the chimeric molecule.
  • Procedures well known in the art can be used for the production of antibodies to the protein products of recombinant nucleic acids of the invention.
  • various hosts including goats, rabbits, rats, mice etc. may be immunized by injection with the protein products (or any portion, fragment, or oligonucleotide thereof which retains immunogenic properties) of the recombinant nucleic acid molecules encoding proteins useful according to the invention.
  • various adjuvants may be used to increase the immunological response.
  • adjuvants include but are not limited to Freund's, mineral gels such as aluminum hydroxide, and surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, and dinitrophenol.
  • BCG Bacilli Calmette-Guerin
  • Corynebacterium parvum are potentially useful human adjuvants.
  • the antigen protein may be conjugated to a conventional carrier in order to increase its immunogenicity, and an antiserum to the peptide-carrier conjugate will be raised.
  • Coupling of a peptide to a carrier protein and immunizations may be performed as described (Dymecki et al., 1992 , J. Biol. Chem., 267: 4815).
  • the serum can be titered against protein antigen by ELISA (below) or alternatively by dot or spot blotting (Boersma and Van Leeuwen, 1994 , J. Neurosci. Methods, 51: 317).
  • the antiserum may be used in tissue sections prepared as described. A useful serum will react strongly with the appropriate peptides by ELISA, for example, following the procedures of Green et al., 1982 , Cell, 28: 477.
  • monoclonal antibodies may be prepared using a candidate antigen (e.g., a mulispecific molecule or a lectin whose level is to be measured or which is to be either inactivated or affinity-purified, preferably bound to a carrier, as described by Arnheiter et al., 1981 , Nature, 294;278.
  • a candidate antigen e.g., a mulispecific molecule or a lectin whose level is to be measured or which is to be either inactivated or affinity-purified, preferably bound to a carrier, as described by Arnheiter et al., 1981 , Nature, 294;278.
  • Monoclonal antibodies are typically obtained from hybridoma tissue cultures or from ascites fluid obtained from animals into which the hybridoma tissue was introduced.
  • Monoclonal antibody-producing hybridomas (or polyclonal sera) can be screened for antibody binding to the target protein.
  • immunological tests rely on the use of either monoclonal or polyclonal antibodies and include enzyme-linked immunoassays (ELISA), immunoblotting and immunoprecipitation (see Voller, 1978 , Diagnostic Horizons, 2:1, Microbiological Associates Quarterly Publication, Walkersville, Md.; Voller et al., 1978 , J. Clin. Pathol., 31: 507; U.S. Reissue Pat. No. 31,006; UK Patent 2,019,408; Butler, 1981 , Methods Enzymol., 73: 482; Maggio, E.
  • ELISA enzyme-linked immunoassays
  • the antibody molecule may have to be labelled to facilitate easy detection of a target protein.
  • Techniques for labelling antibody molecules are well known to those skilled in the art (see Harlow and Lane, 1989, Antibodies, Cold Spring Harbor Laboratory).
  • the multifunctional molecules described herein are useful according to the invention to modulate an immune response in a mammalian, preferably a human, to an antigen or antigens contained in the antigen bearing target which is bound to the lectin portion of the multifunctional molecule.
  • a composition comprising a multifunctional molecule bound to an antigen bearing target is administered to an animal, preferably a human.
  • the second portion of the multifunctional molecule comprising a ligand for a cell-surface molecule of an APC targets the composition to antigen presenting cells in the animal to which the composition has been administered.
  • the antigen bearing target is taken up (i.e., ingested or phagocytosed) by antigen presenting cells.
  • the multifunctional molecule/antigen bearing target complex is contacted with antigen presenting cells in vitro under conditions which allow phagocytosis, wherein the APCs are subsequently returned to the host organinsm from which they were derived.
  • the present invention thus provides a method for modulating an immune response in an mammal comprising administering to the mammal a composition comprising at least a multifunctional molecule as described herein.
  • the composition further comprises an antigen bearing target.
  • the composition still further comprises an APC.
  • an “immune response” refers to stimulation/activation of a selected response involving the immune system, or suppression, elimination, or attenuation of a selected response.
  • an immune response refers to stimulation/activation of a selected response involving the immune system by about at least 5%, or preferably between 5 and 50% or more preferably between 50 and 100% or at least 100% or greater, or suppression, elimination, or attenuation of a selected response by about at least 5%, or preferably between 5 and 50% or more preferably between 50 and 100% or at least 100% or greater, as compared to control cells that are not CD 40-ligand enhanced cells.
  • to modulate an immune response means that the desired response is more efficient, more rapid, greater in magnitude, and/or more easily induced than when an antigen bearing target is contacted with an APC in the absence of a multifunctional molecule.
  • Different immune responses in the subject may be modulated differentially, e.g., the cellular immune response may be selectively enhanced while the humoral response may be selectively attenuated, and vice versa.
  • the following in vitro and in vivo assays are useful for determining whether an immune response is modulated according to the invention.
  • the assays described in detail below measure stimulation or suppression of cellular or humoral immune responses to an antigen.
  • the antigens referred to in the following assays are representative. It will be apparent to one of skill in the art that an immune response to a selected antigen useful according to the invention may be measured using one or more of the following assays by adapting the assay to that antigen.
  • the following assay may be used in order to determine whether opsonin-enhanced cells stimulate phagocytosis by antigen presenting cells.
  • Phagocytosis is examined using monocytes that have been adhered at 37° for 30 min in RPMI without added FCS. Sheep erythrocytes are incubated with an opsonin, or its precursor, under conditions such that there are no more than 300 of such molecules, on average, are deposited on each erythrocyte. If a precursor is used, coated erythrocytes are then processed to convert all precursors to the actual candidate molecule (e.g., See Carlo et al., J. Immunol. 123:523-8(1979)). Fresh monocytes are isolated from the subject, and 5 ⁇ -1 ⁇ 10 5 of these cells suspended in 0.25-0.5 ml of RPMI medium with 1% BSA.
  • erythrocytes suspended at 1.2 ⁇ 10 8 cells/ml
  • the plate is centrifuged for 5 min at 50 g, and incubated for 30 min at 37° C.
  • Non-ingested material is removed in two hypotonic lysis steps using ice-cold lysing buffer before fixing and staining the adherent cells, and examining the cells under light microscopy.
  • Phagocytosis is quantified by determining the percentage of 100 monocytes ingesting one or more target cells, and the total number of ingested E/100 monocyptes (PI) is recorded. Stimulation of phagocytosis according to the invention is indicated by a phagocytic index of equal to or greater than 40.
  • phagocytosis is as follows: Cells of the murine macrophage line are harvested and suspended in DMEM-10 at 4 ⁇ 10 5 /ml. 2.0 ml of this suspension is aliquoted into individual 3.5 cm cell culture plates, and the dishes incubated at 37° C. in 5% CO 2 overnight. Target cells, as well as control cells, are harvested on the same day as the macrophages, washed in PBS, and resuspended 2 min in PKH26 dye (a 2 ⁇ M solution in 1 ml of the supplied diluent) at 5 ⁇ 10 6 cells/ml.
  • PKH26 dye a 2 ⁇ M solution in 1 ml of the supplied diluent
  • the fluorescent PKH26 dye emits in the red spectrum when excited, whereas the FITC label that is used for the phagocytes emits in the green spectrum.
  • PKH26 is stable in the endosomal/lysosomal compartment of phagocytes.
  • the dyed target cells are washed 3 times with PBS and cultured overnight to allow leaching of PKH26 out into the medium. This minimizes leakage of dye during the assay. The following day the target cells are harvested, washed 3 times with PBS, and resuspended in serum-free DMEM at 5 ⁇ 10 5 /ml.
  • the phagocytic cells are rinsed vigorously with PBS on the culture plates in order to remove serum, and 2 ml of target cells is added to each plate After 0, 2, 4, or 8 h, the plates are rinsed 3 times with PBS to remove all non-adhered cells and the remaining cells are incubated with 2 mM EDTA to release them from the plate. The released cells are washed with 1% FBS/PBS, and suspending in 100 ⁇ l of the same buffer. 2 ⁇ g anti-phagocyte (e.g. anti-CR3) antibody is added and the cells placed on ice for 25 min.
  • anti-phagocyte e.g. anti-CR3
  • the cells are washed 3 times with 1% FBS/PBS, resuspended in 100 ⁇ l of this solution, and stained with a 1:25 dilution of FITC-conjugated secondary IgG for 25 min on ice. Cells are washed 3 times and resuspended in 500 ⁇ l 1% FBS/PBS, then analyzed on a Becton Dickinson FACScan with CellQuest software.
  • FL-1 (green) fluorescence is used to gate phagocytes.
  • the FL-2 (red) fluorescence of these cells which reflects internalization of PKH26-labeled target cells, is then measured.
  • Phagocytosis induced by, e.g., an opsonin is indicated by the difference between mean FL-2 fluorescence of macrophages incubated with opsonin-coated versus non-opsonin-coated target cells.
  • Use of an opsonin will increase mean FL-2 fluorescence by, e.g. at least 10%., or enough to obtain ap value less than or equal to 0.05 by student t-test.
  • Proliferative assays have the following applications in clinical studies: (1) Assessment of overall immunologic competence of T cells or B cells as manifested in their ability to respond to polyclonal proliferation signals such as mitogens or anti-CD3 antibodies. Defects in the proliferation may be indicative of fundamental cellular immunologic defect. Low proliferation is often found as a nonspecific secondary effect of chronic disease. (2) Assessment of an individual's response to specific antigens, where low responses are indicative of general or specific immunologic defect. (3) Determination of MHC compatibility by the mixed lymphocyte reaction (MLR).
  • MLR mixed lymphocyte reaction
  • proliferative assays are useful for estimating lymphokine production, investigating signal transduction, and assessing growth factor requirements (e.g., lymphokines) for T or B cells.
  • the procedure outlined here measures incorporation of [ 3 H]thymidine into DNA, which usually correlates well with cell growth as measured by changes in cell number.
  • the activation stimulus is toxic, as with chemical activators such as ionomycin plus phorbol myristate acetate (PMA)
  • the burst of new DNA synthesis following activation may not be accompanied with a net increase in viable cells, and, in fact, a decline in cell number may be observed.
  • [ 3 H]thymidine incorporation in DNA is more indicative of initial cell stimulation than estimation of cell number.
  • [ 3 H]thymidine incorporation provides information on cell populations, not on individual cells. Alternate methods, such as flow cytometry may be used for studies requiring that type of information.
  • This protocol is designed to test the proliferation of T cells in response to a specific antigen—tetanus toxoid. It can be modified to test T cell proliferation in response to any protein or polysaccharide antigen.
  • Materials (T cell suspension, autologous antigen-presenting cell suspension (non-T cells), Tetanus toxoid solution (Connaught or State Laboratory Institute of Massachusetts)).
  • Count T cells and adjust to 1 ⁇ 10 6 cells/ml with complete RPM1-10 AB.
  • Antigen-presenting cells can consist of autologous non-T cells or autologous monocytes/macrophages. (3) Add 100 ul T cell suspension and 50 ul antigen-presenting cell population to wells; mix just before dispensing. (4) Add 50 ul tetanus toxoid solution to give final concentrations of 0, 1, 5, 10, and 20 ug/ml. Prepare three wells for each dilution. (5) Incubate 6 days in a humidified 37° C., 5% CO 2 incubator. (6) Pulse with [ 3 H]thymidine and harvest as described in support protocol.
  • This protocol assays the lymphokine-dependent proliferation of a lymphocyte population, in this case, the IL-4 dependent proliferation of B cells.
  • Materials (Tonsil B cell suspension, Anti-Img cross-linked to Sepharose beads (Bio-Rad), 10,000 U/ml human rIL-4 (Genzyme) in complete RPM1-10).
  • This protocol is used in conjunction with the preceding protocols to complete the [ 3 H] thymidine incorporation assay.
  • (1) Add 20 ul of 50 uCi/ml [ 3 H]thymidine to each culture (1.0 uCi) at a fixed time before terminating the culture (usually 6 or 18 hr).
  • (2) Harvest cell cultures using an automated multiwell harvester that aspirates cells, lyses cells, and transfers DNA onto filter paper, while allowing unincorporated [ 3 H]thymidine to wash out. Fill and aspirate each row of the microtiter plate ten times to ensure complete cell transfer and complete removal of unincorporated thymidine. Wash each filter strip with 100% ethanol to facilitate drying. Transfer to scintillation vials.
  • the capacity of the human immune system to mount an antibody response following in vivo immunization with a protein or polysaccharide antigen is a revealing indication of the overall integrity of both the B and T cell arms of the immune system.
  • in vivo immunization followed by measurement of the antibody response is an appropriate test of immune function in the various acquired and congenital immunodeficiencies and in a host of other conditions affecting the immune system.
  • the following procedures are for in vivo immunization and for the measurement of the subsequent immune response using an ELISA technique.
  • This protocol describes an immunonoenzymetric assay for cytokines using a heterogeneous, noncompetitive immunoassay reaction in which the cytokine is immobilized by a coating antibody bound to a microtiter plate. Unbound material is washed free, and detection is carried out using a different anti-cytokine antibody labeled with the hapten nitroiodophenyl (NIP). This is in turn detected by a horseradish peroxidase (HRPO) conjugate of an anti-NIP antibody, which is revealed with the chromogenic substrate ABTS.
  • HRPO horseradish peroxidase
  • the immunoassay signal increases as a direct function of the amount of cytokine present in the sample.
  • Antibodies are prepared as described in Current Protocols in Immunology, 1995, 6.20.2-6.20.10.
  • Coat assay plate (1) Using a multichannel pipettor, transfer 100 ul of an appropriate dilution of coating antibody into all wells of the assay plate that are to be used. (2) Seal plates with microtiter plate sealer or Parafilm and incubate 2 hr. At 37° C. Prepare samples and standards in preparation plate. (3) Dilute each sample (or aliquot of conditioned medium) to be assayed with an equal volume of immunoassay diluent. (4) Pipet less than or equal to 1 ml of each diluted sample to be assayed into the upper chamber of a separate Spin-X microfiltration device. Microcentifuge 5 min. At 10,000 rpm and save the filtrates that collect in the lower chambers.
  • Read plate and analyze data (21) Using microtiter plate reader with computer interface, measure absorbance in all wells at 405 nm in single-wavelength mode or at 405 and 650 nm in dual-wavelength mode. (22) Fit standard data to a curve described by a first-degree (linear), second degree (quadratic), or four-parameter (nonlinear) mathematical function using curve-fitting software. (23) Interpolate absorbance data from unknown cytokine samples to fitted standard curve, and calculate cytokine concentrations.
  • diptheria and tetanus toxoids are used as representative protein antigens and pneumococcal polysaccharides are used as representative polysaccharide antigens because of their safety and availability. It should be noted, however, that the responses elicited by these antigens are likely to be secondary responses because of past vaccination or natural exposure. To obtain a primary response, an unusual antigen such as keyhole limpet hemocyanin should be used.
  • antigens When antigens are administered by the intramuscular or subcutaneous route, as they are here, a “systemic” immune response is induced and measurement of circulating antibody is most appropriate. It is, however, sometimes of interest to evaluate “local” or mucosal immune responses.
  • the antigen is given either intranasally to stimulate respiratory lymphoid tissue or orally to stimulate gastrointestinal lymphoid tissue and bronchial washings or intestinal fluids, rather than blood, is assayed for antibody content; in addition, antigens are used that are more appropriate for stimulation of the local/mucosal response (i.e., influenza virus antigen for respiratory responses and cholera toxin for gastrointestinal responses).
  • the major antibody response to protein antigen is composed of IgG1 and IgG3 subclass antibodies
  • the major antibody response to polysaccharide antigen is composed of IgG2 subclass antibody.
  • antigens are administered by the intramuscular or subcutaneous route and serum is collected for measurement of responses.
  • (1) Draw preimmunized blood sample, allow blood to clot, and separate serum from clot by centrifugation. Store serum at ⁇ 20° C. to ⁇ 70° C. in appropriately labeled plastic tubes.
  • (2) Inject 0.5 ml of toxoid mixture into an appropriately prepared intramuscular site (deltoid or thigh), taking care not to inject material intravenously.
  • (4) Draw post-immunization blood samples at desired intervals, usually at 1, 2, and 3 weeks. Separate serum and store at ⁇ 20° C. to ⁇ 70° C. (5) After all serum samples are collected, assay samples for presence of antibodies using ELISA.
  • the ELISA offers a rapid, sensitive, reproducible, nonradioactive method for measuring in vivo antibody responses to a variety of antigens, including protein and polysaccharide antigens in sera obtained from individuals vaccinated with tetanus and diphtheria boosters and the polyvalent pneumococcal polysaccharide vaccine.
  • Assays specific for tetanus, diphtheria and the pneumococcal polysaccharide types I, II, and III are detailed in Current Protocols in Immunology, 1995, Vols. 6 and 7.
  • an immunocompent animal is vaccinated with on the order of 10 4 -10 8 irradiated cytokine-coated tumor cells, and challenged with on the order of 10 4 -10 8 live wild-type tumor cells (in any temporal sequence). If survival or tumor onset in these animals differs from that of animal vaccinated, using identical parameters, with irradiated non-cytokine coated cells instead of opsonin-enhanced cells, immunomodulation has occurred. For example, if at least 10% of the animals in the test group survive 100% longer than mean survival in the control group, the test is positive. As another example, onset of tumors in 20% of the test animals might be 50% later than mean onset in the control animals.
  • the invention encompasses methods of modulating an immune response in a mammal to a selected antigen, the method comprising administering to a mammal a therapeutic amount of a composition comprising a multifunctional molecule as described herein, or a composition comprising a multifunctional molecule of the invention and an antigen bearing target, or administering a composition comprising a therapeutic amount of APCs which have been contacted with a multifunctional molecule and antigen bearing target in vitro.
  • compositions described herein may be prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for solution in or suspension in, liquid prior to infection can also be prepared.
  • the preparation can also be emulsified, or encapsulated in liposomes.
  • the active immunogenic ingredients are often mixed with carriers which are pharmaceutically acceptable and compatible with the active ingredient.
  • pharmaceutically acceptable carrier refers to a carrier that does not cause an allergic reaction or other untoward effect in subjects to whom it is administered.
  • a “pharmaceutically acceptable carrier” does not include culture medium, or any solution containing about 0.2-2% serum or greater.
  • Suitable pharmaceutically acceptable carriers include, for example, one or more of water, saline, phosphate buffered saline, dextrose, glycerol, ethanol, or the like and combinations thereof.
  • the vaccine can contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents, and/or adjuvants which enhance the effectiveness of the vaccine.
  • adjuvants which may be effective include but are not limited to: aluminum hydroxide, N-acetyl-muramyl-L-threonyl-D-isoglutamine (thr-MDP), N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine (CGP 11637, referred to as nor-MDP), N-acetylmuramyl-L-alanyl-D-isoglutaminyl-alanine-2-1′-2′-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy)-ethylamine (COP) 19835A, referred to as MTP-PE), and RIBI, which contains three components extracted from bacteria, monophosporyl lipid A, trehalose dimycolate and cell wall skeleton (MPL+TDM+CWS) in a 2% squalene/Tween 80 emulsion.
  • thr-MDP N-acet
  • adjuvants include DDA (dimethyldioctadecylammonium bromide), Freund's complete and incomplete adjuvants and QuilA.
  • immune modulating substances such as lymphokines (e.g., IFN-, IL-2 and IL-12) or synthetic IFN-inducers such as poly I:C can be used in combination with adjuvants described herein.
  • compositions of the invention can be administered parenterally, by injection, for example, either subcutaneously or intramuscularly.
  • Additional formulations which are suitable for other modes of administration include suppositories, and in some cases, oral formulations or formulations suitable for distribution as aerosols.
  • oral formulations the manipulation of T-cell subsets employing adjuvants, antigen packaging, or the addition of individual cytokines to various formulations can result in improved oral vaccines with optimized immune responses.
  • traditional binders and carriers may include, for example, polyalkylene glycols or triglycerides; such suppositories may be formed from mixtures containing the active ingredient in the range of 0.5% to 10%, preferably 1%-2%.
  • Oral formulations include such normally employed excipients as, for example, pharmaceutical grades of mannitol, lactose, starch magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, and the like. These compositions take the form of solutions, suspensions, tablets, pills, capsules, sustained release formulations or powders and contain 10%-95% of active ingredient, preferably 25-70%.
  • compositions of the invention can be formulated into the vaccine compositions as neutral or salt forms.
  • Pharmaceutically acceptable salts include the acid addition salts (formed with free amino groups of the peptide) and which are formed with inorganic acids such as, for example, hydrochloric or phosphoric acids, or with organic acids such as acetic, oxalic, tartaric, maleic, and the like. Salts formed with the free carboxyl groups can also be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium, or ferric hydroides, and such organic bases as isopropylamine, trimethylamine, 2-ethylamino ethanol, histidine, procaine, and the like.
  • Any cellular component of such vaccine compositions can, in preparation for inclusion in such compositions, be subjected to treatments which involve attenuation or inactivation of the cells of the vaccine, including, for example, exposure to ionizing radiation, which can inhibit cell division, antiproliferative agents such as cyclophosphamide, cytochalasin D, or colchicine, or killing with or without fixation.
  • treatments which involve attenuation or inactivation of the cells of the vaccine, including, for example, exposure to ionizing radiation, which can inhibit cell division, antiproliferative agents such as cyclophosphamide, cytochalasin D, or colchicine, or killing with or without fixation.
  • compositions including antigen bearing targets and APCs are administered in a manner compatible with the dosage formulation, and in such amount as will be prophylactically and/or therapeutically effective.
  • the quantity to be administered depends on the subject to be treated, including, e.g., capacity of the subject's immune system to synthesize antibodies, and the degree of protection desired.
  • Suitable dose ranges are on the order of several hundred micrograms active ingredient per vaccination with a preferred range from about 0.1 ⁇ g to 1000 ⁇ g, such as in the range from about 1 ⁇ g to 300 ⁇ g, and preferably in the range from about 10 ⁇ g to 50 ⁇ g.
  • Suitable regiments for initial administration and booster shots are also variable but are typified by an initial administration followed by subsequent inoculations or other administrations.
  • compositions can be given in a single dose schedule, or preferably in a multiple dose schedule.
  • a multiple dose schedule is one in which a primary course of vaccination can include 1-10 separate doses, followed by other doses given at subsequent time intervals required to maintain and or reinforce the immune response, for example, at 1-4 months for a second dose, and if needed, a subsequent dose(s) after several months.
  • Periodic boosters at intervals of 1-5 years, usually 3 years, are preferable to maintain the desired levels of protective immunity.
  • the course of the immunization can be followed by in vitro proliferation assays of peripheral blood lymphocytes (PBLs) co-cultured with ESAT6 or ST-CF, and by measuring the levels of IFN-released from the primed lymphocytes.
  • PBLs peripheral blood lymphocytes
  • the assays can be performed using conventional labels, such as radionucleotides, enzymes, fluorescent labels and the like. These techniques are known to one skilled in the art and can be found in U.S. Pat. Nos. 3,791,932, 4,174,384 and 3,949,064, which are hereby incorporated by reference.
  • the invention contemplates treatment of tumors including but not limited to the following:
  • sarcomas including, e.g., osteosarcomas, Ewing's sarcomas, chondrosarcomas, myosarcomas, synovial cell sarcomas, fibrosarcomas, spindle cell tumors, angiosarcomas, primitive neuroectodermal cell tumors, and Kaposi's sarcomas, lymphomas, acute and chronic leukemias, tumors of the head and neck, nasopharyngeal carcinomas, carcinomas of the pharynx, laryngeal carcinomas, carcinomas of the thyroid, carcinomas of the
  • the present invention provides a method for reducing the size and/or number of metastases in a subject.
  • the method comprises administering to the subject a vaccine composition comprising a multifunctional molecule of the invention.
  • a “subject” as used herein may refer to an organism of the Kingdom animalia, preferably a mammal, and still more preferably a human.
  • a “subject”, according to the invention may also be an animal in need of anti-metastases therapy, e.g., a patient with malignant metastases to one or more organs or tissues, e.g., a human patient with lung or lymph node metastases.
  • a “subject”, according to the invention may also be an animal model of metastases, in which the animal is manipulated, either genetically, or by injection of malignant cells, or by other methods known to those of skill in the art, to simulate the appearance of foci of malignant cells or infected cells which are observed in a similar animal with naturally occurring metastases.
  • the generation of animal models of metastasis is well known in the art, and examples of such models may be found in, for example, Ryan M H et al., J. Immunol. 2001;167:4286-92; Specht J M et al., J Exp Med. 1997;186:1213-21; Nakanishi et al., Tumour Biol.
  • the present invention provides a method of reducing the number and/or size of metastases in a subject comprising administering to a subject, a multifunctional molecule as described herein.
  • a detection and measurement of metastases is routine in the art and may be accomplished using well established methods. For example, metastases may be detected using gross examination of a subject, such as exploratory surgery (e.g., laparotomy). Alternatively, metastases may be detected, measure, and/or observed using less invasive techniques and methods such as thorascopy, mediastinoscopy, and laparoscopy. One of skill in the art may also detect the presence of metastases using imaging techniques known to those of skill in the art.
  • Such techniques include, but are not limited to radiographic imaging, computerized tomography (CT scan), magnetic resonance imaging (MRI), positron emission tomography (PET scan), single photon excitation (SPECT), and radionuclide scintigraphy (e.g., bone scan).
  • CT scan computerized tomography
  • MRI magnetic resonance imaging
  • PET scan positron emission tomography
  • SPECT single photon excitation
  • radionuclide scintigraphy e.g., bone scan.
  • contrast agents e.g., iodine or barium
  • Additional methods for assessing the presence of, or detecting, or measuring metastasis is through the use of gross or histological pathologic examination (i.e., in which a tissue sample is removed from a subject an examined at eaither or both of the gross anatomical level, or at the histological or ultrastructural level according to methods which are well known in the art).
  • gross or histological pathologic examination i.e., in which a tissue sample is removed from a subject an examined at eaither or both of the gross anatomical level, or at the histological or ultrastructural level according to methods which are well known in the art.
  • the above methods for the detection, measurement, and imaging of metastases are known to those of skill in the art and may be adapted according to the knowledge in the art to particular tissues, organs, or cells which one of skill in the art wishes to asses according to the methods of the invention. More detailed descriptions of such methods may be found in the art, for example, the Oxford Textbook of Oncology, 2 nd Ed., New
  • metastasis is detected if any amount of metastasis is detected in a subject. That is, upon the detection of even a single foci in a subject, metastasis may be said to have been detected.
  • metastasis is detected as plural metastatic foci, in one or preferably one or more organs in a subject.
  • a nucleic acid molecule encoding a multifunctional molecule as described herein can be used to produce nonhuman transgenic animals, and cells of such transgenic animals can be isolated and used in a vaccine formulation in animal or human vaccination.
  • a nucleic acid molecule is introduced into a fertilized oocyte or an embryonic stem cell.
  • Such cells can then be used to create non-human transgenic animals in which exogenous nucleic acid molecules encoding the polypeptides of the invention have been introduced into their genome or homologous recombinant animals in which endogenous nucleic acid molecules have been altered.
  • Such animals are useful for studying the function and/or activity of the molecules of the invention and for identifying and/or evaluating modulators of the activity of the molecules of the invention.
  • a “transgenic animal” is a non-human animal, prefers mammal, more preferably a mouse, in which one or more of the cells of the animal includes a transgene.
  • a transgene is exogenous nucleic acid which is integrated into the genome of a cell from which a transgenic animal develops and which remains in the genome of the mature animal, thereby directing the expression of an encoded gene product in one or more cell types or tissues of the transgenic animal.
  • a transgenic animal of the invention can be created by introducing nucleic acid molecules encoding the polypeptides described herein (i.e., a multifunctional molecule) into the male pronuclei of a fertilized oocyte, e.g., by microinjection, and allowing the oocyte to develop in a pseudopregnant female foster animal.
  • Intronic sequences and polyadenylation signals can also be included in the transgene to increase the efficiency of expression of the transgene.
  • a tissue-specific regulatory sequence(s) can be operably linked to the transgene to direct expression of a polypeptide of the invention to particular cells.
  • a transgenic founder animal can be identified based upon the presence of the nucleic acid molecule of the invention, e.g., the transgene in its genome and/or expression of the transgene mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene encoding polypeptides of the invention can further be bred to other transgenic animals carrying other transgenes.
  • the starting point for producing a yeast expression vector was the pUC 19-GM-CSF-mammalian GPI signal sequence plasmid (pUC19-GM-CSF-GPI). This plasmid encodes murine GM-CSF (upstream) fused in-frame to the human Thy-1 GPI modification signal sequence (downstream).
  • GTX-5 5′pAATTCCGCGCCGGCACAGTGCTCAGAGACAAACTGGTCAAGTGTGAG GGCATCAGCCTGCTGGCTCAGAACACCTCGTGGCTGCTGCTGCTCCTGCT GTCCCTCTCCCTCCTCCAGGCCACGGATTTCATGTCCCTGTGACTGGGTA
  • GTX-5 comprises:
  • This oligonucleotide is complementary to GTX-5, except for staggered ends.
  • GTX-5 and GTX-6 were dissolved in individual tubes in sterile water at a final concentration of 1 microgram/lambda. GTX-5 and GTX-6 were mixed at a final concentration of 100 ng/lambda and allowed to anneal for 60 minutes at room temperature.
  • the GTX-5:GTX-6 double stranded oligonucleotide was then cloned into the plasmid pUC19.
  • Four micrograms of pUC19 DNA was digested with EcoRI and KpnI. After electrophoresis, the linear DNA was purified from a 0.7% agarose gel using a Qiagen (Santa Clarita, Calif.) gel purification kit according to instructions provided by the manufacturer. 100 ng of the GTX-5:GTX-6 oligonucleotide was ligated to 200 ng of the EcoRI-KpnI digested pUC19 in a final volume of 20 microliters at room temperature for 60 minutes.
  • the plasmid was transformed into competent AG-1 cells, which were purchased from Stratagene. Transformed E. coli were inoculated onto LB-amp plates. Bacterial colonies grown on LB plates containing ampicillin (100 micrograms/ml) were picked and inoculated into one ml of LB with amp and grown overnight at 37° with shaking.
  • Plasmid DNA was isolated using a standard alkaline lysis miniprep protocol and DNA was digested with EcoRI and KpnI. DNA was electrophoresed on 1.6% agarose gels stained with ethidium bromide, and colonies containing an EcoRI-KpnI fragment of approximately 148 bp were thus identified. Positive colonies were inoculated into 100 ml of LB with ampicillin and grown overnight. Plasmid DNA was again purified using kits purchased from Qiagen.
  • pUC-GPI 21 The nucleotide sequence of a Thy-GPI positive clone, designated pUC-GPI 21, was sequenced, confirming its identity.
  • the GM-CSF coding sequence was amplified by PCR from a mouse lung cDNA library purchased from Clontech. PCR was performed for 35 cycles using pfu polymerase and the following primers: Upstream 5′CCGAATTCATGTGGCTGCAGAATTTACTTTTCCTGGGCATTGTGGTCT AC3′ Downstream 5′CAGCCGGCTTTTTGGACTGGTTTTTTGCATTCAAAGGGGATATCAGTC AG3′
  • PCR parameters were denaturation at 90° for 1 minute, annealing at 60° for 1 minute, and extension at 720 for 1 minute.
  • the GM-CSF chain PCR product was purified after electrophoresis through a 1% agarose gel.
  • the DNA band was excised and the DNA fragment purified using a kit purchased from Qiagen.
  • the purified GM-CSF DNA fragment was digested with EcoRI and NgoM1. After digestion, the reaction mix was extracted with phenol:chloroform (1:1) followed by chloroform. The aqueous phase was adjusted to 0.3M sodium acetate pH 5.2 and the DNA was precipitated with 2 volumes of ethanol at ⁇ 80° for 2 hours. The DNA was pelleted by centrifugation, ethanol was removed, and the pellet was rinsed with 70% ethanol. The pellet was dried under vacuum.
  • the GM-CSF DNA was resuspended in sterile water and ligated to pUC19-GPI 21 that had been digested with EcoRI-NgoM1. Ligation was for one hour at room temperature. PUC19 GPI 21 ligated to GM-CSF DNA was used to transform competent AG-1 cells. Transformed AG-1 cells were selected on LB plates with ampicillin. Plasmid DNA was isolated and analyzed as above. Restriction digests were performed to confirm the pUC 19 GPI-GM-CSF chimeric construct. The DNA from several positive clones was isolated and sequenced.
  • This plasmid was digested with NgoMIV and KpnI, and the larger resulting fragment isolated after electrophoresis through a 1% agarose gel.
  • the 280 bp GPI modification signal sequence from the yeast protein Gas1 was amplified by PCR from the yeast cosmid clone C9952 (ATCC). This PCR employed pfu polymerase and the primers: Upstream Primer 5′GTAGCCGGCGCTAGCTCGGGGTCTTCTTCCAAGTCTA Downstream Primer 5′TACGGTACCCCTAGGCCACAATGAAATAAGATACCATACC3′
  • These primers add a 5′ NgoMIV site and a 3′ KpnI site to the Gas I fragment.
  • the PCR product was purified after electrophoresis through a 1% agarose gel and digested with NgoM IV and KpnI.
  • the Gas1 GPI signal sequence was then ligated into the pUC19-GM-CSF-GPI plasmid prepared above so that the Gas1 signal sequence was fused in-frame downstream of the GM-CSF sequence, replacing the Thy-1 sequence.
  • This vector is termed pUC19-GMCSF-Gas1.1.
  • the resultant plasmid was then transformed into AG-1 competent E. coli (Stratagene) and plasmid clones were isolated by alkaline lysis mini-prep. Plamids were then screened for inserts by restriction digest. DNA from a positive clone was sequenced to confirm the identity of the GAS1 coding region.
  • a yeast expression plasmid for GPI-GM-CSF was then generated utilizing the pITY-4 vector, which was kindly provided by Dr. K. Dane Wittrup (University of Illinois). This plasmid stably integrates into the yeast genome and allows high-level expression of heterologous genes.
  • pITY-4 include: a delta sequence (LTR of Ty element) that enables multiple integration events by homologous recombination; a neo/kanamycin resistance gene that provides for selection in E.
  • yeast are grown in dextrose-containing media for 3 days, then are switched to media containing galactose to induce transcription of genes inserted downstream of the Gal1 promoter.
  • the GMCSF-Gas1 insert described above was amplified by PCR from pUC 19-GMCSF-Gas1.1 using pfu polymerase and the primers: Upstream 5′TACGGCCGGCACCCACCCGCTCACCC3′ Downstream 5′TACGGCCGCCACAATGAAAATAAGATACCAT3′ These primers add EagI sites at both ends for cloning into the pITY-4 plasmid.
  • the PCR product was purified after electrophoresis through a 1% agarose gel and digested with EagI.
  • the EagI-flanked GMCSF-Gas1 fragment was ligated into EagI-digested pITY-4 and used to transform E. coli AG1 cells.
  • E. coli were then grown on kanamycin-containing LB plates (100 ug/ml). Plasmids from kanamycin resistant colonies were purified by mini-prep and mapped by restriction digests for presence and correct orientation of inserts. The identity of a positive clone was confirmed by sequencing. This plasmid is termed pITY-GMCSF-Gas1.1.
  • a 50 ml culture of the E. coli clone containing pITY-GMCSF-Gas1.1 was grown in LB with 100 ug/ml kanamycin and the plasmid purified using a Midi-Prep Kit from Qiagen.
  • the S. cerevesiae strain BJ5464 ATCC was then transformed with pITY-GMCSF-Gas 1.1 using a lithium acetate (LiAc) protocol.
  • a 10 ml overnight culture of BJ5464 in YPD Per liter: 20 g Bactotryptone, 10 g yeast extract, 20 g dextrose
  • Yeast were grown for 3 hours at 30° and then harvested by centrifugation at 12,000 ⁇ g for 2 minutes at room temperature. Cells were washed with sterile water and centrifuged again. The cells were resuspended in 1.0 ml of 100 mM LiAc, transferred to a 1.5 ml microfuge tube and centrifuged in an Eppendorf microfuge at top speed for 15 seconds. The cells were then resuspended in 0.5 ml of 100 mM LiAc and 50 uL samples were aliquoted to individual tubes. The cells were pelleted.
  • G418-resistant yeast Individual colonies of G418-resistant yeast were picked and grown in one ml of YPD with 1 mg/ml G418 for 3 days. The cells were then pelleted by centrifugation in a microfuge and the YPD (dextrose-containing, galactose-free) media was replaced with YPG (20 g bactotryptone, 10 g yeast extract, 20 g galactose per liter) with 1 mg/ml G418. Yeast were grown in YPG for 3 days to allow full induction of transcription from the Gal1 promoter.
  • Yeast were lysed by vortexing with acid-washed glass beads (425-600 microns, Sigma). Insoluble material was pelleted and the supernatant assayed using a murine GM-CSF ELISA (Endogen). A colony expressing high levels of GPI-GM-CSF was identified. Based on standard curve of soluble GMCSF, we estimate expression to be approximately 25 ug/L, a significant improvement over mammalian expression and sufficient for in vivo experiments. This yeast clone is designated SC-GM-GPI.
  • GPI-GM-CSF on a scale suitable for in vitro and in vivo functional characterization
  • 500 ml of YPD was inoculated with SC-GM-GPI and grown for three days at 300 with shaking.
  • Cells were pelleted by centrifugation at 12,000 ⁇ g for 2 minutes at room temperature and transferred to an equal volume of YPG for an additional three days of growth.
  • Cells were then pelleted, washed with TN and lysed in 25 ml of TN containing 20 mM OGP, 1 mM PMSF, and lug/ml each aprotinin, leupeptin and pepstatin.
  • Soluble yeast-derived material was applied to the column and allowed to flow by gravity.
  • the column was washed sequentially with: (a) 20 volumes of TN with 1% Triton X-100; (b) 5 volumes of 50 mM Tris pH 8.0, 1 mM OGP; (c) 20 volumes TN with 1 mM OGP.
  • Bound material was then eluted with 10 volumes of 0.15M NaCl, 25 mM Tris pH 2.5 with 1 mM OGP. Eluted material was neutralized with ⁇ fraction (1/200) ⁇ volume of 1.5M Tris pH8.8.
  • the purified material was concentrated using a Microsep 3K centrifugal device (Pall Gelman Laboratory).
  • GPI-GM-CSF Yields of GPI-GM-CSF were determined by ELISA (Endogen) to be 25 ug/L of culture. Final concentration was adjusted to 40 ug/ml by addition of 0.15M NaCl, 25 mM Tris pH 7.4 with 1 mM OGP.
  • Purified GPI-GM-CSF was analyzed by stained gel and western blot. Approximately lug of purified GPI-GM-CSF or recombinant soluble murine GM-CSF per lane were electrophoresed. Gels were then stained with silver nitrate using the Sigma silver staining kit according to the manufacturer's directions (Sigma). For western blots, gels were transferred to Protran BA83 (Schleicher and Schuell) using an Owl Scientific electric transblotter and blocked with TBS (Tris Buffered Saline) containing 0.05% Tween 20 and 2% nonfat dry milk overnight at room temperature.
  • TBS Tris Buffered Saline
  • the blot was then incubated with primary antibody (rat monoclonal anti-murine GMCSF, Endogen) at 1:5000 dilution in blocking buffer for 2 hours at room temperature.
  • primary antibody rat monoclonal anti-murine GMCSF, Endogen
  • the blot was washed with TBS-0.05% Tween 20, and incubated with a secondary antibody, alkaline phosphatase conjugated goat anti-rat IgG (Sigma) at 1:10,000 for 1 hour at room temperature. After washing, color was developed with NBT-BCIP (Sigma).
  • NBT-BCIP Sigma
  • these bands appear to represent GPI-GM-CSF. While some high molecular weight material, possibly representing aggregates, is visible in the blot, this material is not visible in the less sensitive silver stain, indicating that it is present in lower amount than the dominant band.
  • Wild type CMS-5 murine fibrosarcoma cells grown in DMEM, 10% FBS, Pen-Strep were harvested, washed twice with RPMI 1640 (Life Technologies) and resuspended in RPMI 1640 at a concentration of 5 ⁇ 10 5 cells/ml. 0.9 ml aliquots of the cell suspension were dispensed to Eppendorf siliconized microfuge tubes. Each aliquot received either 1 ug of purified GPI-GM-CSF prepared as in Example 2, 1 ug of soluble recombinant murine GM-CSF (Intergen, supplied as lyophilized powder and reconstituted at 40 ug/ml in the same buffer as GPI-GM-CSF), or media alone. Cells were then incubated for 3 hours at 37° C. with shaking and then washed 3 times with PBS containing 2% FBS.
  • GPI-GM-CSF For detection of GPI-GM-CSF by flow cytometry, cells were incubated with a rat anti-murine GM-CSF monoclonal antibody (Endogen) for one hour at 4° C. The cells were then washed 3 times with PBS containing 2% FBS, and incubated with FITC-labeled goat anti-rat IgG antibody (Sigma) for one hour at 4° C., and again washed 3 times with PBS containing 2% FBS. The cells were analyzed by flow cytometry on a Becton-Dickinson Facscalibur. Decoration with GPI-GM-CSF caused an approximately 10-fold increase in peak and mean FL-1 fluorescence relative to cells incubated with media alone. In contrast, cells incubated with soluble GM-CSF had virtually the same profile as the negative control cells. This data indicates that GPI-GM-CSF, but not soluble recombinant GM-CSF, can bind to tumor cells.
  • GPI-GM-CSF attached to CMS-5 cells was also detected and quantitated by ELISA.
  • CMS-5 cells were harvested and washed as described above. 1 ⁇ 10 6 cells in 1 ml of RPMI 1640 were incubated with 1 ug of purified GPI-GM-CSF. After incubation for 2 hours at 37° C., the cells were washed 3 times with PBS containing 2% FBS. The cell pellet was lysed with 50 microliters of PBS containing 0.15% deoxycholate and the detergent subsequently diluted by the addition of 200 microliters of PBS.
  • the material was serially diluted with PBS and amounts of GM-CSF determined using an ELISA kit (Endogen) against a soluble, recombinant GM-CSF standard provided by the manufacturer. Based on this data, the mean number of GPI-GM-CSF molecules incorporated/cell over five experiments was 37,000+/ ⁇ 33,000. The large standard deviation was due to one experiment in which the number of molecules/cell was 66,000. Excluding this experiment, the mean was 29,500+/ ⁇ 4,500.
  • CMS-5 cells were harvested and decorated as described above in Example 3. After decoration, the cells were washed 3 times with PBS containing 2% FBS and then resuspended at 4 ⁇ 10 6 cells/ml in RPMI 1640. The cells were irradiated at 3500 rads from a 137 CS source. The cells were then incubated at 37° C. in 5% CO 2 and aliquots were removed at hourly intervals, washed three times, and lysed in 50 ul PBS with 0.15% deoxycholate. 200 ul of PBS was then added to dilute the deoxycholate. Cell-associated GM-CSF was measured by ELISA.
  • the bioactivity of GPI-GM-CSF was assayed by determining the molecule's ability to support the proliferation of the FDC-P1 cell line, a murine bone-marrow derived, GM-CSF dependent cell line.
  • Proliferation of FDC cells was measured with the Biotrak Cell Proliferation ELISA (Amersham Pharmacia), an assay that utilizes the thymidine analogue 5-bromo-2′-deoxyuridine (BrdU).
  • WEHI cells ATCC were grown in Iscove MEM, 10% FBS, Penicillin-streptomycin, as a source of conditioned media for FDC-P1 cells.
  • FDC-P1 cells were grown in DMEM, 10% FBS, Penicillin-streptomycin with 25% WEHI conditioned media, harvested, and washed 3 times with DMEM, 10% FBS, Penicillin-streptomycin. The cells were resuspended at 1 ⁇ 10 5 /ml in DMEM, 10% FBS, Penicillin-streptomycin and 100 uL was aliquoted to individual wells of a 96 well microtitre plate. Groups, done in triplicate, were as follows:
  • the non-isotopic proliferation assay was performed according to the manufacturer's instructions.
  • the plated cells were grown for two days at 37° C. in 5% CO 2 .
  • 10 ul of the BrdU solution was added to individual wells and the cells incubated for 3 more hours.
  • the plate was then centrifuged at 300 ⁇ g for 10 minutes and the supernatant removed.
  • the plate was dried by incubating at 60° C. for one hour.
  • the plate was then fixed and blocked according to the manufacturer's instructions.
  • the fixed cells were then incubated with peroxidase-labelled anti-BrdU for 90 minutes.
  • the wells were then washed and color developed with TMB according to the manufacturer's instructions.
  • GPI-GM-CSF consistently sustained proliferation at a level somewhat (about 25%) higher than did soluble recombinant GM-CSF, indicating that GPI-GM-CSF is suprabioactive.
  • the effect of GPI-GM-CSF was not due to the GPI moiety alone, since denatured GPI-GM-CSF did not support proliferation.
  • the GPI moiety remained linked to the protein after denaturation, since the protein was still able to decorate cells as demonstrated by ELISA, which recognizes linear epitopes on GM-CSF.
  • CMS-5 cells were grown to 70% confluence in DMEM, 10% FBS, Penicillin-streptomycin, harvested trypsinization, and washed 3 times with RPMI 1640. Viability was determined by trypan blue staining of an aliquot and the cells were then resuspended at a concentration of 4 ⁇ 10 6 cells/ml a 1 ul aliquots dispensed into siliconized microfuge tubes. The cells were incubated with 1 ug GPI-GM-CSF or 1 ug soluble recombinant murine GM-CSF per 10 6 cells for 3 hours at 37° C.
  • “Washed” groups were then washed 3 times with PBS, 2% FBS and resuspended at 4 ⁇ 10 6 cells/ml in RPMI 1640. An aliquot of the washed GPI-GM-CSF decorated cells was removed and the amount of cell-associated GM-CSF measured by ELISA as described above. There were approximately 31,000 and 32,000 GPI-GM-CSF molecules/cell in the washed decorated groups in the two experiments, respectively.
  • mice which are syngeneic for CMS-5
  • the cells were irradiated at 3500 rads from a 137 CS source.
  • 8-10 week-old female Balb/c mice (which are syngeneic for CMS-5) were anesthetized by metofane inhalation and vaccinated subcutaneously in the left inguinal fold with 1 ⁇ 10 6 cells in 0.25 ml.
  • wild-type CMS-5 cells at 70% confluence were harvested and washed 3 times in HBSS. Viability was determined by trypan blue staining of an aliquot and cells were adjusted to 4 ⁇ 10 6 /ml in HBSS.
  • the previously vaccinated mice were then injected subcutaneously behind the neck, under metofane anesthesia, with 2 ⁇ 10 6 live, wild-type CMS-5 cells in 0.5 ml HBSS.
  • Tumor development was assessed daily by palpation and visual inspection. “Onset” was defined as the first day on which a tumor mass was both palpable and visible. The observer was blinded to the vaccine received by each set of mice to ensure against bias. Mice were sacrificed by CO2 asphyxiation when tumors become unwieldy. Experiments were terminated 70 days after tumor challenge, as planned in advance.
  • Human GM-CSF is amplified by PCR from a human T cell cDNA library (Clontech) using Pfu polymerase (Stratagene). The following primers are used: Upstream 5′GCGAATCCCGGCCGGCACCCGCCCGCTCGCCCAGCCCC Downstream 5′CAGCCGGCCTCCTGGACTGGCTCCCAGCAGTC
  • the upstream primer contains EcoR1 and Eag1 restriction sites immediately preceding the first amino acid found in the mature human GM-CSF protein. Since expression in S. cerevisiae utilizes a yeast leader sequence, cloning of the human GM-CSF begins at the N terminus of the mature protein. Each downstream primer omits the native stop codon to allow in-frame ligation to the sequence encoding the Gas1 GPI modification signal. The downstream primer contains an NgoM IV restriction site, consistent with restriction sites used in other constructs.
  • PCR parameters are denaturation at 97° C for 1 minute
  • the PCR product is isolated by electrophoresis through a 1% agarose gel and eluted from the excised agarose band using a commercially available kit (Qiagen).
  • the purified hGM-CSF DNA fragment is digested with EcoR1 and NgoM IV and ligated to the (murine) pUC19 GM-CSF-GPI plasmid that has been digested with EcoR1 and NgoM IV. This replaces the murine GM-CSF with its human counterpart.
  • the pUC19-hGM-CSF GPI plasmid is then transformed into competent AG-1 E. coli cells, 30 colonies are picked for mini-culture, and plasmid clones are isolated and purified using commercially available kits (Qiagen). Positive clones are identified by restriction enzyme test digest and agarose gel electrophoresis. Positive E. coli colonies are grown overnight in maxi-culture and their plasmids purified using Qiagen maxi-prep kits. Insert
  • PCR of this construct from the pUC19 vector is performed.
  • the primers are: 5′TACGGCCGGCACCCGCCCGCTCGCCCAGCCCC 3′TACGGCCGCCACAATGAAAATAAGATACCAT
  • the upstream primer has an EagI site immediately preceding the first codon of the mature GM-CSF. This removes the mammalian secretion signal and allows for in-frame ligation to the yeast signal sequence. The same restriction site can be used as for the mouse construct because it is absent in the human sequence.
  • the downstream primer appends an EagI site at the 3′ end.
  • PCR is performed using Pfu polymerase for 25 cycles. Conditions for PCR are: denaturation 90° one minute, annealing 60° one minute, extension 720 one minute. After amplification, the reaction mix is allowed to cool at 4° for 10 minutes.
  • the PCR product is isolated by electrophoresis through a 1% agarose gel and eluted from the excised agarose band using a commercially available kit (Qiagen).
  • the purified GM-CSF GAS1g DNA fragment is digested with EagI, ligated to pITY-4, and transformed into AG-1 chemically competent bacteria (Stratagene). 30 colonies are picked for mini-culture and plasmid clones are isolated and purified using commercially available kits (Qiagen). Positive clones are identified by restriction enzyme test digest and agarose gel electrophoresis. Positive E. coli colonies are grown overnight in maxi-culture and their plasmids purified using Qiagen maxi-prep kits. Inserts are sequenced.
  • the GPI-human GM-CSF molecule is expressed in S. cerevesiae as described for the murine molecule in Example 2. Immunoaffinity purification is performed as described in Example 2, substituting an anti-human GM-CSF antibody for the anti-murine GM-CSF antibody. ELISA to detect and quantitate the molecule, whether in isolation or bound to an antigen bearing target, is performed using an anti-human GM-CSF monoclonal antibody, as is flow cytometry on cells decorated with the molecule.
  • pUC19 GM-CSF-K-HA was cloned starting with pUC19 GM-CSF-K-Gas1.1, which we produced in our laboratory.
  • This plasmid includes a sequence that encodes murine GM-CSF fused to a downstream glycosylphosphatidylinositol modification sequence derived from the yeast GAS 1 protein (the latter obtained from Dr. D. Wittrup, University of Illinois).
  • a linker sequence is interposed between the GM-CSF and GAS 1 portions.
  • the plasmid pUC19 GMCSF-Gas1.1 also previously produced in our lab, was digested with NgoM IV and NheI.
  • the plasmid pUC19 GM-CSF-K-HA was produced, which encodes a chimeric protein containing (from amino terminal to carboxy terminal): (1) murine GM-CSF; (2) the (G 4 S) 2 linker described above; and (3) the HA1 domain of the H1 HA from the A/PR/8/34 influenza A isolate.
  • the HA1 sequence used (amino acids 18 to 344 of the HA precursor) omits the N-terminal leader sequence and the downstream HA2 domain. A termination codon was added after amino acid 344.
  • pUC 19 GM-CSF-K-Gas 1.1 was digested with Nhe I and Kpn L. Nhe I cuts at the 5′ end of the Gas 1.1 coding sequence and Kpn I cuts at the 3′ end of the Gas 1.1 coding sequence, respectively.
  • the resulting plasmid with the GPI coding region removed was purified after electrophoresis through agarose gel using a kit manufactured by Qiagen.
  • the HA1 coding sequence was cloned by PCR from a plasmid encoding the HA gene of the A/PR/8/34 strain of influenza. The HA1 sequence used begins at amino acid 18, the start of the mature protein, i.e. lacking the secretion signal sequence.
  • the product was electrophoresed through a 1.0% agarose gel and the HA1 cDNA was extracted from the gel using a Qiagen kit according to the manufacturer's instructions.
  • the purified HA1 DNA fragment was digested with Nhe I and Kpn I.
  • the purified Nhe 1-Kpn I HA fragment was ligated into the pUC 19 GM-CSF-K-Gas1.1 vector that had been digested with Nhe I and Kpn I to remove the Gas1.1 coding region.
  • the DNA was used to transform E. coli AG1 and transformants selected on LB-ampicillin plates. Plasmid DNA from individual colonies was isolated and digested with restriction enzymes. Restriction digests identified a pUC19 GM-CSF-K-HA plasmid.
  • the pUC19 GM-CSF-K-HA plasmid was purified according to the manufacturer's instructions using a kit purchased from Qiagen.
  • PCR of pUC19 GM-CSF-K-HA was used to isolate a DNA fragment encoding GM-CSF-K-HA for cloning into a yeast expression vector.
  • the PCR product contains Eag I cloning sites for in frame insertion into the yeast expression vector.
  • Upstream Primer 5′ TACGGCCGGCACCCACCCGCTCACCC Downstream Primer 5′ ATGGTACCCGGCCGTTATCATCTGGATTGAATGGACGG
  • the product was electrophoresed through a 1.0% agarose gel and the GM-CSF-K-HA gene was extracted from the gel using a Qiagen kit according to the manufacturers instructions.
  • the purified DNA fragment was digested with Fag I and ligated to the yeast expression vector ITK that had been digested with Eag I.
  • the ITK vector is designed for (1) replication in E. coli and (2) expression of genes in the yeast Saccharomyces cerevisiae after stable integration using homologous recombination.
  • the vector contains:
  • This plasmid was used to transform E. coli strain AG-1. Transformants were selected by growth on LB plates containing 100 ug/ml kanamycin. Individual colonies were grown in LB media containing kanamycin and plasmids were purified. Restriction digests determined orientation of inserts. The resulting plasmid ITK GM-CSF-K-HA was purified using a kit purchased from Qiagen according to the manufacturer's instructions.
  • the purified plasmid was linearized with Mfe 1 and used to transform the yeast strain Saccharomyces cerevisiae WDHY131 using lithium acetate (LiAc).
  • a 10 ml culture of S. cerevisiae grown to saturation at 30° in YPD media per liter/20 g Bactotryptone; 20 g dextrose: 10 g yeast extract
  • the culture was grown at 300 with shaking for 3 hours.
  • the yeast were harvested by centrifugation at 11,000 ⁇ g for 2 minutes and resuspended in 25 ml of sterile water.
  • the yeast were centrifuged as above and resuspended in 1.0 ml of 100 mM lithium acetate and transferred to a 1.5 ml microfuge tube. The yeast were pelleted by centrifugation at 12,000 ⁇ g for 15 seconds and the supernatant removed. The cells were resuspended in 0.5 ml of 100 mM LiAc. 50 uL of cell suspension was added to individual microfuge tubes and centrifuged as above. Supernatant was removed.
  • Transformation mix added to the yeast pellet consisted of: 240 uL PEG (50% w/v); 36 uL 1.0 M LiAc; 5 uL single stranded DNA (10 mg/ml) and 1 ug of linearized ITK GM-CSF-K-HA in 75 uL of water. The mixture was vortexed to resuspend the cell pellet and incubated at 30° for 30 minutes. The cells were then shocked at 42° for 15 minutes, centrifuged to pellet cells and resuspended in 0.5 ml of YPD. Yeast were incubated in YPD media for 3 hours and plated on YPD plates containing 2 mg/ml G418. Plates were grown at 30° for 3 days until individual colonies appeared.
  • GM-CSF-K-HA To screen for expression of GM-CSF-K-HA, individual colonies were grown in 1 ml of YPD media at 300 for 2 days. The cells were centrifuged at 8,000 ⁇ g for 2 minutes and the YPD media removed and replaced with 1 ml of YPG media (per liter/20 g Bactotryptone; 20 g galactose; 10 g yeast extract) for induction from the gal promoter. Yeast were grown in YPG media for 2 days. At this time, an aliquot was removed and cells were pelleted. The supernatant was tested for GM-CSF expression using an ELISA kit purchased from Endogen. Protocol was according to the manufacturer. A high-expressing yeast clone secreting the chimeric protein GM-CSF-K-HA was identified. Based on standard curve of soluble GMCSF, expression level was approximately 2.4 mg/L of GM-CSF moiety.
  • the plasmid pUC19 HA-K-GM-CSF was also produced, which encodes a chimeric protein containing (from amino terminal to carboxy terminal): (1) an HA1 domain (2) K, the (G 4 S) 2 linker described above, and (3) murine GM-CSF,
  • the HA1 begins at the amino terminus of the mature protein, amino acid 18, eliminating the leader sequence.
  • the 3′ end terminates at amino acid 344.
  • the (G 4 S) 2 has been added to supply a flexible linker.
  • the GM-CSF begins at amino acid 18 of the GM-CSF protein, corresponding to the first amino acid of the mature protein.
  • the HA-K sequence was first cloned by PCR of the HA1 coding sequence from a plasmid encoding the HA gene of the A/PR/8134 strain of influenza.
  • Upstream Primer 5′ CTGAATTCCGGCCGGACACAATATGTATAGGC
  • Downstream Primer 5′ ATGGTACCGCTGCCCCCGCCGCCGGAGCCCCCTCCGCCACTTCTGGA TTGAATGGACGGAAT
  • the oligonucleotides for PCR generate a nucleic acid with:
  • the product was electrophoresed through a 1.0% agarose gel and the GM-CSF gene was extracted from the gel using a Qiagen kit according to the manufacturer's instructions.
  • the purified fragment was digested with Kpn I and BamHI and the fragment was ligated into pUC19 HA-K plasmid that had been digested with KpnI and BamHI.
  • the plasmid was used to transform E. coli AG-1 to amp r . Individual colonies were picked and grown in LB-amp. The identity of plasmids with the correct insert was determined by restriction mapping.
  • the resulting plasmid termed pUC19 HA-K-GM-CSF was purified using a Qiagen kit according to the manufacturer's instructions.
  • PCR of pUC19 HA-K-GM-CSF was used to generate a DNA fragment encoding HA-K-GM-CSF for cloning into a yeast expression vector.
  • the PCR product contains Eag I cloning sites for in-frame insertion into the yeast expression vector.
  • Upstream Primer 5′ CTGAATTCCGGCCGGACACAATATGTATAGGC
  • the product was electrophoresed through a 1.0% agarose gel and the HA-K-GM-CSF gene was extracted from the gel using a Qiagen kit according to the manufacturers instructions.
  • the purified DNA fragment was digested with Eag I and ligated to the yeast expression vector ITK, that had been digested with Eag I.
  • the ITK vector is designed for (1) replication in E. coli and (2) expression of genes in the yeast Saccharomyces cerevisiae after stable integration using homologous recombination.
  • the vector contains:
  • This plasmid was used to transform E. coli strain AG-1. Transformants were selected by growth on LB plates containing 100 ug/ml kanamycin. Individual colonies were grown in LB media containing kanamycin and plasmids were purified. Restriction digests determined orientation of inserts. The resulting plasmid ITK HA-K-GM-CSF was purified using a kit purchased from Qiagen according to the manufacturer's instructions.
  • the purified plasmid was linearized with Mfe 1 and used to transform the yeast strain Saccharomyces cerevisiae WDHY131 using lithium acetate (LiAc).
  • a 10 ml culture of S. cerevisiae grown to saturation at 30° C. in YPD media per liter/20 g Bactotryptone; 20 g dextrose; 10 g yeast extract
  • the culture was grown at 30° C. with shaking for 3 hours.
  • the yeast were harvested by centrifugation at 11,000 ⁇ g for 2 minutes and resuspended in 25 ml of sterile water.
  • the yeast were centrifuged as above and resuspended in 1.0 ml of 100 mM lithium acetate and transferred to a 1.5 ml microfuge tube. The yeast were pelleted by centrifugation at 12,000 ⁇ g for 15 seconds and the supernatant removed. The cells were resuspended in 0.5 ml of 100 mM LiAc. 50 uL of cell suspension was added to individual microfuge tubes and centrifuged as above. Supernatant was removed.
  • Transformation mix added to the yeast pellet consisted of: 240 uL PEG (50% w/v); 36 uL 1.0 M LiAc; 5 uL single stranded DNA (10 mg/ml) and 1 ug of linearized ITK HA-K-GM-CSF in 75 uL of water. The mixture was vortexed to resuspend the cell pellet and incubated at 300 for 30 minutes. The cells were then shocked at 42° C. for 15 minutes, centrifuged to pellet cells and resuspended in 0.5 ml of YPD. Yeast were incubated in YPD media for 3 hours and plated on YPD plates containing 2 mg/ml G418. Plates were grown at 30° C.
  • HA-K-GM-CSF To screen for expression of HA-K-GM-CSF, individual colonies were grown in 1 ml of YPD media at 30° C. for 2 days. The cells were centrifuged at 8,000 ⁇ g for 2 minutes and the YPD media removed and replaced with 1 ml of YPG media (per liter/20 g Bactotryptone; 20 g galactose; 10 g yeast extract) for induction from the gal promoter. Yeast were grown in YPG media for 2 days. At this time, an aliquot was removed and cells were pelleted. The supernatant was tested for GM-CSF expression using an ELISA kit purchased from Endogen. The protocol was according to the manufacturer.
  • a colony expressing high levels of the chimeric protein was identified. Based on standard curve of soluble GMCSF, expression level is approximately 2.0 mg/L of soluble material. There is no decrease in expression levels in the absence of G418.
  • yeast were inoculated into 500 ml of YPD and grown for three days at 30° C. Cells were pelleted by centrifugation at 12,000 ⁇ g for 2 minutes and transferred to an equal volume of YPG for an additional three days of growth. The cells were then pelleted by centrifugation at 12,000 ⁇ g for 2 minutes and the supernatant collected.
  • the soluble material was applied to an immunoaffinity column of anti-murine GMCSF monoclonal antibody (Endogen) linked to cyanogen bromide-activated Sepharose 4B (Sigma). Coupling of the monoclonal to the Sepharose was performed according to the manufacturer. Efficiency of coupling was monitored using OD 280 and of binding of GMCSF to immobolized antibody was tested using soluble, commercially available material.
  • Soluble yeast-derived material was applied to the column and allowed to flow by gravity.
  • the column was washed with: (a) 20 volumes of 0.15M NaCl, 25 mM Tris pH 7.4 (TN) (b) 5 volumes of 50 mM Tris pH 8.0 (c) 20 volumes TN.
  • Bound material was then eluted with 10 volumes of 0.15M NaCl, 25 mM Tris pH 2.5. Eluted material was neutralized with 1/200 volume of 1.5M Tris pH8.8.
  • the purified material was concentrated using a Microsep 3K centrifugal devise (Pall Gelman Laboratory). Yields of chimeric protein were determined by ELISA (Endogen) according to the manufacturer's instructions.
  • GM-CSF-K-HA Purified GM-CSF-K-HA was analyzed by western blot. Approximately lug of GM-K-HA per lane was electrophoresed along with soluble GMCSF. For western blot, gels were transferred to Protran BA83 (Schleicher and Schuell), blocked with TBS (Tris Buffered Saline) containing 0.05% Tween 20 and 2% Nonfat Dry Milk. The blot was incubated with primary antibody (rat monoclonal anti-murine GMCSF, Endogen) at 1:5000 dilution in blocking buffer for 2 hours at room temperature. The blot was washed with TBS-0.05% Tween 20. Secondary antibody, alkaline phosphatase conjugated anti-rat IgG (Sigma) was incubated at 1:10,000 for 1 hour at room temperature.
  • primary antibody rat monoclonal anti-murine GMCSF, Endogen
  • GM-CSF-K-HA Purified GM-CSF-K-HA was used to decorate CMS 5 murine fibrosarcoma cells.
  • CMS 5 cells were grown in DMEM, 10% FBS, Penicillin-streptomycin, harvested by trypsinization and washed 3 times with RPMI 1640 (Gibco). Cells were diluted to 1 ⁇ 10 6 /ml in RPMI 1640 and 0.9 ml were aliquoted to siliconized tubes. Cells were incubated for 2 hours at 37° C. with shaking and then washed 3 times with PBS containing 2% FBS. Primary antibody, rat anti-murine GMCSF monoclonal, was incubated for one hour at 4° C.
  • Cells were washed as above, treated with FITC labeled anti-rat antibody (Sigma), and incubated for one hour at 4° C. After additional washing, the cells were analyzed by flow cytometry, which confirmed the presence of GM-CSF-K-HA on the surface of the tumor cells.
  • CMS 5 cells were harvested and washed as described above. 1 ⁇ 10 6 cells in 1 ml of RPMI 1640 were incubated with 1 ug of purified GM-K-HA. After incubation for 15 min, 30 min, 1 hour, or 2 hours at 4° C., room temperature, or 37° C., the cells were washed 3 times with PBS containing 2% FBS. The cell pellet was lysed with 50 microliters of PBS containing 0.15% deoxycholate and the detergent subsequently diluted by the addition of 200 microliters of PBS. The material was serially diluted with PBS and tested by ELISA (Endogen).
  • GM-CSF molecules associated with each cell Based on the amount of GM-CSF detected in the cell lysates, it was possible to quantitate the average number of GM-CSF molecules associated with each cell. For example, after a 15 min incubation at 4° C., 58,700 molecules were present per cell. After a 15 min incubation at room temperature, 25,700 molecules were present per cell. After a 15 min incubation at 37° C., 17,200 molecules were present per cell.
  • CMS-5 murine fibrosarcoma cells were grown to 70% confluence in DMEM, 10% FBS, Penicillin-streptomycin, harvested by trypsinization, and washed 3 times with RPMI 1640. Viability was determined by trypan blue staining of an aliquot and the cells were then resuspended at a concentration of 4 ⁇ 10 6 cells/ml and 1 ml aliquots dispensed into siliconized microfuge tubes. The cells were incubated with 1 ug (microgram) murine GM-CSF-K-HA or 10 ng (nanograms) HA-K-murine GM-CSF per 10 6 cells for 3 hours at 37° C.
  • Cells were then washed 3 times with RPMI 1640 and resuspended at 4 ⁇ 10 6 cells/ml in RPMI 1640. An aliquot of the cells was removed and the amount of cell-associated GM-CSF measured by ELISA as described above. There were approximately 20,240 and 18,000 molecules/cell in the GM-CSF-K-HA and HA-K-GM-CSF groups, respectively. Cells for a control vaccine, to be administered without a molecule of the invention (or any other immunomodulator), were prepared in parallel.
  • the cells were irradiated at 3500 rads from a 137 Cs source.
  • 8 week-old female Balb/c mice (which are syngeneic for CMS-5) were anesthetized by metofane inhalation and vaccinated subcutaneously in the left inguinal fold with 1 ⁇ 10 6 cells in 0.25 ml. Each mouse received cells from only one vaccine type.
  • wild-type CMS-5 cells at 70% confluence were harvested and washed 3 times in HBSS. Viability was determined by trypan blue staining of an aliquot and cells were adjusted to 4 ⁇ 10 6 /ml in HBSS.
  • mice were then injected subcutaneously behind the neck, under metofane anesthesia, with 2 ⁇ 10 6 live, wild-type CMS-5 cells in 0.5 ml HBSS.
  • the groups receiving the HA-K-GM-CSF and control vaccines each consisted of 5 mice, whereas the group receiving the GM-CSF-K-HA vaccine consisted of 4 mice because 1 mouse failed to awaken from anesthesia.
  • pUC19 human GM-CSF-K-HA (hGM-CSF-K-HA) is cloned starting with pUC19 GM-CSF-K-HA.
  • pUC19 GM-CSF-K-HA. is digested with EcoRI and NgoM IV. EcoRI cuts at the 5′ end of the murine GM-CSF coding sequence and Ngo M IV cuts at the 3′ end of the murine GM-CSF molecule.
  • the resulting plasmid with the murine GM-CSF coding region removed is purified after electrophoresis through agarose gel using a kit manufactured by Qiagen.
  • the human GM-CSF coding segment is generated by PCR from a commercially available human cDNA library (Clontech).
  • the human sequence begins at amino acid 18, the start of the mature protein, i.e. lacking the secretory signal sequence.
  • the 3′ end corresponds to amino acid 144, eliminating the endogenous termination codon.
  • the product is electrophoresed through a 1.0% agarose gel and the hGM-CSF gene is extracted from the gel using a Qiagen kit according to the manufacturer's instructions.
  • the purified hGM-CSF DNA fragment is digested with Eco RI and NgoM IV and ligated into the pUC 19 murine GM-CSF-K-HA vector that has been digested with EcoRI and NgoM IV to remove the murine GM-CSF sequence.
  • the DNA is used to transform E. coli AG1 and transformants are selected on LB-ampicillin plates. Plasmid DNA from individual colonies is isolated and digested with restriction enzymes to identify clone harboring a pUC19 hGM-CSF-K-HA plasmid.
  • the pUC19 hGM-CSF-K-HA plasmid is purified according to the manufacturer's instructions using a kit purchased from Qiagen.
  • PCR of pUC19 hGM-CSF-K-HA is used to generate a DNA fragment encoding hGM-CSF-K-HA for cloning into a yeast expression vector.
  • the PCR product contains Eag I cloning sites for in frame insertion into the yeast expression vector. Upstream Primer 5′ GCGAATTCCGGCCGGCACCCGCCCGCTCGCCCAGC Downstream Primer 5′ ATGGTACCCGGCCGTTATCATCTGGATTGAATGGACGG
  • the product is electrophoresed through a 1.0% agarose gel and the hGM-CSF-K-HA gene is extracted from the gel using a Qiagen kit according to the manufacturer's instructions.
  • the purified DNA fragment is digested with Eag I and ligated to the yeast expression vector ITK that has been digested with Eag I.
  • the ITK vector is designed for (1) replication in E. coli and (2) expression of genes in the yeast Saccharomyces cerevisiae after stable integration using homologous recombination.
  • the vector contains:
  • This plasmid is used to transform E. coli strain AG-1. Transformants are selected by growth on LB plates containing 100 ug/ml kanamycin. Individual colonies are grown in LB media containing kanamycin and plasmids are purified. Restriction digests determine orientation of inserts. The resulting plasmid ITK hGM-CSF-K-HA is purified using a kit purchased from Qiagen according to the manufacturer's instructions.
  • the purified plasmid is linearized with Mfe 1 and used to transform the yeast strain Saccharomyces cerevisiae WDHY131 using lithium acetate (LiAc).
  • a 10 ml culture of S. cerevisiae grown to saturation at 30° in YPD media per liter/20 g Bactotryptone; 20 g dextrose; 10 g yeast extract) is used to inoculate 100 ml of YPD.
  • the culture is grown at 30° with shaking for 3 hours.
  • the yeast are harvested by centrifugation at 11,000 ⁇ g for 2 minutes and resuspended in 25 ml of sterile water.
  • the yeast are centrifuged as above and resuspended in 1.0 ml of 100 mM lithium acetate and transferred to a 1.5 ml microfuge tube.
  • the yeast are pelleted by centrifugation at 12,000 ⁇ g for 15 seconds and the supernatant removed.
  • the cells are resuspended in 0.5 ml of 100 mM LiAc. 50 uL of cell suspension is added to individual microfuge tubes and centrifuged as above. Supernatant is removed.
  • Transformation mix added to the yeast pellet consists of: 240 uL PEG (50% w/v); 36 uL 1.0 M LiAc; 5 uL single stranded DNA (10 mg/ml) and 1 ug of linearized ITK hGM-CSF-K-HA in 75 uL of water.
  • the mixture is vortexed to resuspend the cell pellet and incubated at 30° for 30 minutes.
  • the cells are then shocked at 42° for 15 minutes, centrifuged to pellet, and resuspended in 0.5 ml of YPD.
  • Yeast are incubated in YPD media for 3 hours and plated on YPD plates containing 2 mg/ml G418. Plates are grown at 30° for 3 days until individual colonies appear.
  • hGM-CSF-K-HA To screen for expression of hGM-CSF-K-HA, individual colonies are grown in 1 ml of YPD media at 30° for 2 days. The cells are centrifuged at 8,000 ⁇ g for 2 minutes and the YPD media removed and replaced with 1 ml of YPG media (per liter/20 g Bactotryptone; 20 g galactose; 10 g yeast extract) for induction from the gal promoter. Yeast are grown in YPG media for 2 day. An aliquot is then removed and the cells are pelleted. The supernatant is tested for hGM-CSF expression using an ELISA kit purchased from Endogen. Protocol is according to the manufacturer.
  • B16F10 murine melanoma cells were harvested and washed three times in PBS. Cells were then suspended at 5 ⁇ 10 5 viable cells/ml in PBS, with viability determined by staining an aliquot of cells with Trypan blue. 100 ul of this suspension was injected into the tail veins of 8-10 week old female C57BL/6 mice. On day 1 or day 3 after tumor challenge, mice were immunized with 1 ⁇ 10 6 irradiated B16F10 cells subcutaneously in the left inguinal fold.
  • mice received either cells alone, cells mixed with 1 ug soluble recombinant murine GM-CSF (Serologicals Corp.), or cells mixed with 1 ug of a multifunctional molecule of the invention comprising murine GM-CSF at the N terminus, a (Gly 4 Ser) 2 flexible linker, and the HA1 domain of influenza A/PR/8/34 hemagglutinin at the C terminus.
  • the latter composition comprised both free and cell-bound multifunctional molecule.
  • mice were sacrificed on day 12, the thoracic cavity opened with dissecting scissors, and the lungs removed en bloc by tracheal transection. Metastases were enumerated with a hand lens. In the mice immunized 1 day after challenge, the average number of metastases/mouse was as follows: Cells alone: 30.00 Cells + GM-CSF: 14.33 Cells + multifunctional molecule: 0.67
  • composition comprising a multifunctional molecule of the invention was able to effectively reduce metastases and treat disease.
  • C57BL/6 mice (haplotype b) were immunized with C3H (haplotype k)-derived K1735 melanoma cells, followed by challenge with C57BL/6-derived B16F10 melanoma cells.
  • K1735 cells were grown to 70% confluence in DMEM with 10% FBS and penicillin-streptomycin, harvested by trypsinization, and washed 3 times with RPMI 1640. Viability was determined by trypan blue staining of an aliquot and the cells were then resuspended at a concentration of 4 ⁇ 10 6 cells/ml for K1735. One ml aliquots were then dispensed into siliconized microfuge tubes.
  • the cells were incubated with 1 ug mGM-CSF-HA1 (a fusion polypeptide consisting of murine GM-CSF at the N terminus, a (Gly 4 Ser) 2 linker, and the HA1 domain of influenza AIPR/8/34) per 10 6 cells for 2 hours at 4° C. An aliquot of the cells was removed for measurement of cell-associated GM-CSF by ELISA. Mean cell-associated GM-CSF across two experiments was approximately 60,000. Cells that were not admixed with any polypeptide and, in one experiment, cells mixed with 1 ug soluble murine GM-CSF (Serologicals Corp.) were prepared in parallel as control vaccines.
  • mGM-CSF-HA1 a fusion polypeptide consisting of murine GM-CSF at the N terminus, a (Gly 4 Ser) 2 linker, and the HA1 domain of influenza AIPR/8/3
  • mice 8 week-old female C57BL/6 mice were anesthetized by metofane inhalation and vaccinated subcutaneously in the left inguinal fold with or 1 ⁇ 10 6 cells in 0.25 ml RPMI, along with a total of 1 ug GM-CSF-HA1 (including bound and free fusion polypeptide). Each mouse received cells from only one vaccine type. Seven days later, B16F10 cells, as appropriate, at 70% confluence were harvested and washed 3 times in HBSS. Viability was determined by trypan blue staining of an aliquot and cells were adjusted in HBSS to 1 ⁇ 10 5 /ml. The previously vaccinated mice were then challenged subcutaneously behind the neck, under metofane anesthesia, with 0.5 ml of the B16F10 cell suspension.
  • Tumor development was assessed daily by palpation and visual inspection. “Onset” was defined as the first day on which a tumor mass was both palpable and visible. The observer was blinded to the vaccine received by each set of mice to ensure against bias. Mice were sacrificed by CO2 asphyxiation when tumors become unwieldy. Experiments were terminated 70 days after tumor challenge, as planned in advance.
  • mice that had been vaccinated with cells admixed with fusion polypeptide remained tumor-free.
  • 10/10 mice that had been vaccinated with cells alone developed tumors, as did 4/5 mice vaccinated with cells admixed with soluble murine GM-CSF.
  • integrin Homo sapiens integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), mRNA
  • LRP1 lipoprotein receptor-related protein
  • GABA-A receptor pi subunit gene GABA-A receptor pi subunit gene

Abstract

The present invention also relates to a method of reducing metastases in a subject comprising administering to the subject a composition comprising a multifunctional molecule comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell.

Description

    RELATED APPLICATIONS
  • The present application is a divisional application to U.S. Utility Application with Ser. No. 10/645,000, filed Aug. 20, 2003, which claims priority to U.S. Provisional application 60/404,823, filed Aug. 20, 2002 and 60/487,407, filed Jul. 15, 2003, the entirety of each is hereby incorporated by reference.
  • BACKGROUND OF THE INVENTION
  • Typically, the specific modulation of an immune response to an antigen in a subject requires the administration of another substance, e.g. an adjuvant, in admixture with the antigen in order to initiate and/or direct the modulation. Traditional adjuvants, though, have a number of weaknesses. For example, many are crude, heterogeneous preparations. In addition, many are relatively weak immunomodulators, and some cause severe local inflammation that is unacceptable in humans. Purified soluble polypeptides, such as cytokines, have some advantages over crude adjuvants, but their value is limited because they diffuse away from the antigen upon administration. While certain cell-surface molecules may be potential immunomdulators as components of cell-based vaccines, their application generally involves gene transfer into the cells, which is often problematic.
  • The invention therefore fills heretofore unmet needs by providing molecules that can bind to antigen bearing targets, such as cells, viruses, and isolated antigens, and that can serve as immunomodulators when administered with an antigen bearing target. In addition, the invention provides compositions comprising these molecules and related methods. The compositions and methods of the invention are also useful for other applications, e.g. any application in which it is desirable to attach a biological effeector, such as a polypeptide ligand for a cell surface receptor, to a target structure, such as a virus or a cell.
  • SUMMARY OF THE INVENTION
  • The present invention relates to a multifunctional molecule, e.g. a fusion polypeptide, comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell. In a preferred embodiment, the first part is a first cell surface binding moiety and the second part is a second cell surface binding moiety. In this embodiment, the first cell surface binding moiety can attach to a virus or cell, e.g. a tumor cell, which comprises an antigen. It is also particularly preferred that the second cell surface binding moiety can bind to a cell-surface polypeptide, e.g. a non-immunoglobulin polypeptide, of an antigen presenting cell (APC). Thus, in some embodiments, a multifunctional molecule of the invention can serve as a bridge or link between an antigen bearing target and an APC.
  • As used herein an “antigen bearing target” is an entity which comprises an antigen. As used herein an “antigen bearing target” includes, for example, a whole cell which expresses an antigen a cell fraction comprising an antigen, a membrane fraction comprising an antigen, a virus comprising an antigen, a viral particle comprising an antigen, or an antigen, e.g. a polypeptide antigen, which may be free of any other cell-derived or virus-derived material. Cellular fractions may be prepared using methods known to those of skill in the art such as those taught in Cell Biology A Laboratory Handbook (Academic Press 1994 Editor J. E. Celis ISBN 0-12-164715-3)
  • The term “antigen” as used herein refers to a molecule against which a subject can initiate a humoral and/or cellular immune response. Antigens can be any type of biologic molecule including, for example, simple intermediary metabolites, sugars, lipids, and hormones as well as macromolecules such as complex carbohydrates, phospholipids, nucleic acids and proteins. Common categories of antigens include, but are not limited to, viral antigens, bacterial antigens, fungal antigens, protozoa and other parasitic antigens, tumor antigens, antigens involved in autoimmune disease, allergy and graft rejection, and other miscellaneous antigens. In the compositions and methods of the invention, it is preferred that the antigen is a polypeptide, e.g., one comprising at least seven amino acids.
  • As used herein, “antigen presenting cell” or “APC” refers to cells that ingest and present antigen to T cells. These cells include phagocytic leukocytes, macrophages, and dendritic cells, B lymphocytes, and endothelial cells. A “professional APC” is an APC that is constitutively able to activate a T lymphocyte. Professional APCs typically constitutively express class II major histocompatibility molecules and costimulatory molecules such as B7-1 and/or B7-2.
  • In one embodiment, the invention encompasses a multifunctional molecule, the first part of which is a lectin. Thus, the multifunctional molecule can bind to one or more carbohydrates of an antigen bearing target. In a preferred embodiment of the invention, the first part of the multifunctional molecule is a lectin and the second portion is a ligand for a cell surface protein (e.g., a ligand for a cell surface receptor). Preferably, the cell surface protein is a cell surface receptor of an APC. Ligands for a cell surface receptor include any ligand which will bind to a cell surface protein, and preferably include, but are not limited to, an opsonin, cytokine, adhesion molecule, counterreceptor of a T cell costimulatory molecule, a defensin, a ligand for a CD40 molecule, or a heat shock protein, or a portion of any of these ligands, including about (or at least about) 5, 8, 10, 12, 15, 20, 25, 35, 50, 60, 70, 80, 100, or 120 contiguous amino acids of such a ligand. Preferably, the multifunctional molecule which comprises first and second parts comprises an amino acid sequence which can bind to a cell surface protein (e.g., a cell surface receptor) including, but not limited to an adhesion molecule, a costimulatory molecule for a T cell, or a receptor for at least one of the following types of molecules: a cytokine, a defensin, a heat shock protein, a CD40 molecule, or an opsonin.
  • A cell surface protein (e.g., a cell surface receptor) useful in the present invention is any cell surface molecule which can bind the ligand portion of a multifunctional molecule of the invention. Preferably, the cell surface receptor is a CD40 molecule, a T cell costimulatory molecule, an adhesion molecule, or a receptor for a cytokine, a defensin, a heat shock protein, an opsonin, or an adhesion molecule. Cell surface proteins, useful in the invention include, but are not limited to the cell surface molecules identified by GenBank Accession number in Appendix I and II, or those cell surface molecules which are encoded by a nucleic acid molecule identified by GenBank Accession number in Appendix I or II.
  • The term “cytokine” as used herein refers to a polypeptide molecule that is naturally secreted by mammalian cells and that binds to a cell surface protein on a leukocyte, inducing a change (e.g., a change in the proliferative state, a change in the transcriptional profile or a change in the propensity to migrate) in the leukocyte (other than mere occupancy of the leukocyte's receptors for the cytokine). “Change” refers to at least about a 5% increase or decrease as compared to in the absence of a cytokine. The term “cytokine” also refers herein to a polypeptide molecule that is a ligand for a receptor for a naturally occurring cytokine.
  • Examples of cytokines which are useful in the methods and compositions of the invention include the following: GM-CSF, Il-2, IL-4, IL-6, IL-12, ligands for hematopoietin receptors, ligands for immunoglobulin superfamily receptors, ligands for interferon receptors, ligands for TNF receptors, and ligands for chemokine receptors. An antibody against a cytokine receptor can also be a cytokine.
  • In one embodiment of the invention, it is preferred that a cytokine comprised by a composition of the invention promote a Th1 immune response, i.e., the generation of T cells that express Th1 cytokines such as IL-2 and IFN-γ. In another embodiment, it is preferred that a cytokine comprised by a composition of the invention promote a Th2 immune response, i.e., the generation of T cells that express Th2 cytokines such as IL-4 and IL-10.
  • “Engineered cytokines” as described herein are cytokines which comprise a heterologous cell surface binding moiety.
  • The term “opsonin” as used herein refers to naturally occurring and non-naturally occurring molecules which are capable, by virtue of being contemporaneously bound or attached to both an antigen-containing cell and an antigen-presenting cell (APC), of acting as a link or coupling agent (an adapter) between the antigen and the APC to allow more efficient binding, engulfment, and internalization of the antigen-containing cell by the APC. An opsonin useful according to the invention, also includes non-naturally occurring opsonins capable of binding to APCs via receptors that can bind naturally occurring opsonins.
  • The term “opsonin” as used herein can also refer to molecules which can be processed such that at least one product of the processing step or steps is capable of, by virtue of being contemporaneously bound or attached to both an antigen-containing cell and an APC, acting as a link or coupling agent to allow more efficient binding, engulfment, and internalization of other antigen-containing cells by the APC. An opsonin can also be any polypeptide chain of a multichain opsonin.
  • Examples of opsonins which are useful in the methods and compositions of the invention include the following: vitronectin, fibronectin, complement components such as C1q (including any of its component polypeptide chains A, B and C), complement fragments such as C3d, C3b and C4b, mannose binding protein, conglutinin, surfactant proteins A and D, C-reactive protein (CRP), alpha-2-macroglobulin, and immunoglobulins, for example, the Fc portion of an immunoglobulin.
  • “Innate opsonins” are opsonins of the innate immune system and are known in the art as secreted polypeptide molecules of the innate immune system and are believed to bind contemporaneously to an antigen and to the surface of an APC. They can thus act as “bridges”, and are thought, by virtue of this property, to promote internalization of antigens by APCs. The mode in which opsonins bind to antigens varies among opsonins, and can be covalent or noncovalent. In general, the antigen-binding moieties of innate opsonins differ from the antigen-binding moieties of immunoglobulins in that the former are relatively invariant among members of the same species, and do not undergo diversification during the ontogeny of an individual.
  • A molecule containing a naturally occurring APC-binding moiety shall be considered an opsonin if it contains a moiety through which it can be stably bound or attached to a cell such that the APC-binding moiety is located in the extracellular space, whether or not the opsonin molecule contains its natural antigen-binding domain.
  • “Engineered opsonins”, as described herein, include molecules in which a cell surface binding moiety is substituted for the natural antigen-binding domain of an opsonin or where a cell surface binding moiety is linked to the opsonin without modification or removal of the natural antigen-binding domain of the opsonin.
  • A “cell surface binding moiety” is a moiety through which a molecule can be stably bound to a cell surface, e.g. a cell wall, a polysaccharide capsule, or the lipid or protein component of a plasma membrane, or to the surface of a virus. Such moieties include but are not limited to crosslinking moieties and lipid moieties. It is preferred that the cell surface binding moiety bind to a cell by a means other than interaction of a polypeptide with its cognate cell-surface polypeptide. It is further preferred that the cell surface binding moiety comprise a non-polypeptide moiety. In a preferred embodiment, a lipid moiety is linked to the engineered molecule via a glycosylphosphatidylinositol (GPI) moiety. In another preferred embodiment, the lipid comprises a fatty acid, e.g. palmitate. In yet another preferred embodiment of the invention, the cell surface binding moiety is linked to an opsonin or an antigen-binding domain-truncated opsonin at the antigen-binding end of the opsonin. In another preferred embodiment, the multifunctional molecule comprises an idiotypic portion of an immunoglobulin which can bind to an APC. Preferably, the opsonin of an opsonin-enhanced cell is one of alpha′ chain C3b or mannose binding protein.
  • If the opsonin is a fragment of C3, it is preferred hat it bind to CR1 with a greater affinity than to CR2. It is further preferred that the fragment of C3 not be a ligand for CR2. Preferably, the opsonin is neither C3bi, C3d, nor C3dg.
  • It is preferred that the opsonins bind to receptors that trigger phagocytosis and that are non-clonotypic and thus do not vary from cell to cell as, for example, clonotypic receptors do. Non-clonotypic receptors are present on cells which play a role in innate immunity, and include, e.g., non-idiotypic receptors. Examples of such receptors include CR1, CR2, CR3, CR4, and C1q receptor, receptors containing a component of the C1q receptor, collectin receptors, receptors for α2m, receptors for CRP, and Fc receptors for immunoglobulins.
  • “Exogenous” refers to something which is introduced from or produced outside the cell.
  • “Endogenous” refers to something which is expressed or present naturally in a cell.
  • “Heterologous” refers to something which is not naturally expressed in a cell.
  • Preferably, the multifunctional molecule which comprises first and second parts can bind, via the second part, to the surface or plasma membrane of an antigen presenting cell (APC), i.e. a cell that can present antigen to a T cell, e.g. a cell that can activate a T cell, at least in part by presenting antigen to the T cell. The APC may be a leukocyte, e.g. a cell of monocytic lineage and/or a dendritic cell. Preferably, binding of the multifunctional molecule is independent of expression of an idiotype, e.g. a clonotypic determinant of an immunoglobulin, on the APC. Most preferably, the multifunctional molecule comprises a first end which can bind to a cell that comprises an antigen and a second end which can bind to a APC.
  • The multifunctional molecule may bind to an antigen bearing target cell by, e.g., inserting into the lipid portion of a cell membrane or by binding to a structure, e.g. a polypeptide or a carbohydrate, that is physically associated with the lipid portion of the membrane. The structure need not be directly in contact with the lipid portion of the membrane, but may be indirectly attached, e.g. a carbohydrate that is part of a cell-surface glycoprotein. Preferably the multifunctional molecule can bind via a first part to an antigen bearing target, preferably a mammalian cell that comprises an antigen, and via a second part to an APC. The invention also encompasses the use of a molecule that can bind via a first part to a virus or to a non-mammalian cell, e.g. a fungal or bacterial cell, and via a second part to an APC. In the latter cases, the first part may bind, e.g., to a component of a cell wall or a capsule.
  • In a preferred embodiment, the multifunctional molecule which comprises first and second parts comprises a first part which comprises a lectin and a second part that can bind to a leukocyte, e.g. an APC, e.g. a cell of monocytic lineage or a dendritic cell (which may itself be of monocytic lineage). A “lectin”, according to the invention, is a molecule or part of a molecule, e.g. an amino acid sequence, which can bind to a carbohydrate, e.g. a polysaccharide. Families of naturally occurring lectins include:
    • 1) Galectins, a rapidly growing family of animal lectins. All of them share galactose-specificity.
    • 2) Calcium-dependent (C-type) animal lectins, an extremely large family composed of members having diverse structures and functions.
    • 3) Among this C-type lectin family, selectins form a distinguishable subfamily by their specific function in leukocyte adhesion to endothelial cells through sialyl-Lewis X recognition.
    • 4) Collectins, another subfamily of C-type lectins specific for mannose, which have a unique structure consisting of a C-type lectin domain and a collagen-like domain. They are involved in innate immunity.
    • 5) Invertebrates are known to contain various lectins in their body fluids, probably as body-protection factors. Recently, some lectins from an echinoderm were found to show hemolytic activity.
    • 6) Annexins, a group of proteins having affinity to lipids that were recently shown to be lectins showing binding to glycosaminoglycans.
    • 7) The legume lectin family, which consists of a large number of members, such as ConA, with variable saccharide specificity comparable to C-type lectins.
    • 8) Ricin, the first lectin investigated in Russia more than 100 years ago. It is now evident that the ricin family has many other homologous members which differ in either toxicity or sugar-binding specificities.
  • Thus, a multifunctional molecule of the invention may bind to one or more carbohydrates. Carbohydrates to which lectins may bind also include, for example, carbohydrates comprising lactose, D-mannose, D-glucose, D-fucose, L-fucose (e.g. alpha-L-fucose), D-galactose, blood group A oligosaccharides, blood group B oligosaccharides, saccharides comprising alpha-D-Gal(1->3)[alpha-Lfuc(1->2)]-beta-D-Gal(1->3/4-beta-D-GlcNAc, saccharides comprising alpha-sialyl [2->3]-lactose, alpha-D-mannosyl glycoconjugates, alpha-NeuNAc-[2->6]-Gal, alpha-NeuNAc-[2->6]-GalNAc, alpha-NeuNAc-[2->3]-Gal, N-acetyl-beta-D-glucosamine, terminal alpha-D-galactosyl residues, terminal beta-D-galactosyl residues, N-acetyllactosamine, terminal alpha-D-mannosyl residues, N-acetyl-beta-D-glucosamine, terminal N-acetyl-D-galactosamine, N-acetylneuraminic acid, and terminal alpha-D-galactosaminyl residues.
  • The multifunctional molecule which comprises a lectin may comprise, for example, the whole of a naturally occurring lectin or a portion of a naturally occurring lectin, e.g about (or at least about) 5, 8, 10, 12, 15, 20, 25, 35, 50, 60, 70, 80, 100, or 120 contiguous amino acids of a naturally occurring polypeptide lectin. In one embodiment the multifunctional molecule comprises a carbohydrate-binding domain of a naturally occurring lectin, i.e., a portion of a lectin that can bind to a carbohydrate in the absence of the remainder of the lectin. In another embodiment the lectin may be non-naturally occurring, e.g. identified from an artificial library of molecules or designed by modifying the structure of a naturally occurring lectin.
  • Lectins known as “hemagglutinins” bind to carbohydrates on erythrocytes, e.g. blood group antigens, and when incubated with these cells cause them to aggregate. The influenza virus hemagglutinin, for example, binds to sialic acid (as does the human parainfluenza virus 3 hemagglutinin/neuraminidase). There are at least 15 known influenza hemagglutinin subtypes, defined by their distinct antigenic properties. Any of these subtypes, designated, e.g., H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, and H15, may provide amino acid sequences useful in the compositions and methods of the invention. In one embodiment of the invention, the hemagglutinin is of a subtype from a virus that infects humans, e.g. H1, H2, or H3. In another embodiment, the hemagglutinin is of a subtype from a virus that does not infect humans, e.g. one of H4 through H15. Amino acid sequences can vary up to about 20% for influenza hemagglutinins within a given subtype, and can vary between about 30% and about 70% for influenza hemagglutinins from different subtypes.
  • Influenza hemagglutinin is expressed as a single polypeptide chain, designated HA0, which trimerizes post-translationally. HA0 is proteolytically cleaved to yield two domains, HA1 and HA2, which are disulfide-bonded to each other. HA1 comprises significant sialic acid binding activity, while HA2 is anchored to the viral membrane and facilitates fusion of this membrane with a host cell membrane. In preferred embodiments of the invention, the multifunctional molecule comprising first and second parts comprises an amino acid sequence of an HA1 domain.
  • The molecule may be a fusion polypeptide which comprises one or more amino acids interposed between the first and second parts which bind to cells, e.g. a fusion polypeptide which comprises a first amino acid sequence which can bind to an antigen bearing target and a second amino acid sequence which can bind to a leukocyte, and which further comprises at least one amino acid interposed between the first and second parts. The interposed amino acids may comprise, e.g., a linker sequence intended to lessen steric hindrance or other undesirable interactions between the aforementioned first and second parts. For, example, one such type of sequence takes the form (Gly3Ser)n. Additional useful linkers include, but are not limited to (Arg-Ala-Arg-Asp-Pro-Arg-Val-Pro-Val-Ala-Thr)1-5 (Xu et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96: 151-156), (Gly-Ser)n (Shao et al., 2000, Bioconjug. Chem. 11: 822-826), (Thr-Ser-Pro), (Kroon et al., 2000, Eur. J. Biochem. 267: 6740-6752), (Gly-Gly-Gly)n (Kluczyk et al., 2000, Peptides 21: 1411-1420), and (Glu-Lys), (Klyczyk et al., 2000, supra), wherein n is 1 to 15 (each of the preceding references is also incorporated herein by reference). In another embodiment, no amino acids are interposed between the first and second parts.
  • The present invention further provides a nucleic acid molecule, preferably a recombinant nucleic acid molecule which encodes a multifunctional polypeptide of the present invention. The nucleic acid molecule may be, for example, DNA, RNA, cDNA, or mRNA. The nucleic acid molecule may be naturally occuring or may be partially or wholly synthesized using techniques known to those of skill in the art. In a preferred embodiment, the nucleic acid molecule is a DNA molecule comprising a first nucleic acid sequence encoding a first amino acid sequence which can bind to an antigen bearing target, and a second nucleic acid sequence encoding a second amino acid sequence which can bind to a cell surface receptor on an APC.
  • The present invention still further provides a vector comprising the nucleic acid molecule encoding a multifunctional polypeptide of the invention, e.g. an expression vector suitable for expressing in a host cell, wherein the host cell is preferably a eukaryotic cell, more preferably an animal cell, more preferably a mammalian cell, and still more preferably a human cell. In another preferred embodiment the host cell is a yeast cell, e.g. Saccharomyces cerevesiae.
  • The invention also provides a host cell comprising a nucleic acid vector which comprises a sequence encoding the multifunctional molecule of the present invention. Preferably, the host cell is a eukaryotic cell, such as a yeast cell- or an animal cell, preferably a human cell. The host cell may also be a prokaryotic cell.
  • The invention also encompasses a molecule, e.g. a polypeptide, e.g. a fusion polypeptide, which comprises a first part that can bind to an antigen bearing target, e.g. a cell, e.g. a cell that comprises an antigen, and a second part that can bind to a cell, e.g. a leukocyte, e.g. an APC. The molecule may have any of the characteristics taught in the descriptions of methods and compositions herein. Preferably the first and second parts are heterologous to each other. The molecule may be, e.g., a recombinant polypeptide expressed in a mammalian cell, an insect cell, a plant cell, a yeast cell, or a bacterial cell.
  • The invention also encompasses a method of modulating an immune response in an animal comprising the step of expressing in an animal, e.g. expressing in a host cell of the animal, a multifunctional molecule of the invention, e.g. a polypeptide which comprises a first part that can bind to a antigen bearing target and a second part that can bind to a cell. According to the invention, “expressing in an animal” means “causing to be present in an animal”. When the molecule is a polypeptide, it is preferably expressed by introducing into the host cell, in vivo or ex vivo, a nucleic acid encoding the polypeptide. If the nucleic acid is introduced into the host cell ex vivo, the host cell may subsequently be administered to the animal. In a preferred embodiment, the method further comprises administering to the animal the antigen to which the immune response is modulated. For example, the antigen may be administered to the animal as part of a composition which further comprises a nucleic acid that encodes the multifunctional molecule. In another preferred embodiment, the antigen is already present in the animal at the time the multifunctional molecule is expressed. In yet another preferred embodiment, the antigen is administered to the animal after administration of the multifunctional molecule. In still other preferred embodiments, the antigen is expressed in the animal, e.g. by administering to the animal a composition comprising a nucleic acid encoding the antigen, either before or after expression of the multifunctional molecule in the animal. In another embodiment, nucleic acid sequences encoding the multifunctional molecule and the antigen are introduced into one or more host cells of the animal, e.g. by administering to the animal a composition comprising those nucleic acid sequences.
  • As used herein, the term “modulating an immune response” to a selected antigen using the methods and compositions of the invention means rendering the response more or less efficient, more or less rapid, greater or lesser in magnitude, and/or more or less easily induced than the response obtained from administration of a composition which is identical in every respect except that it does not comprise a multifunctional molecule of the invention. In a preferred embodiment, the response is between about 5 and 100%, or preferably between about 5 and 50% or more preferably between about 5 and 25% more or less efficient, more or less rapid, greater or lesser in magnitude, and/or more or less easily induced than the response obtained from administration of a composition which is identical in every respect except that it does not comprise a multifunctional molecule of the invention.
  • The term “modulate the immune response” may refer to stimulation/activation of an immune response to a selected antigen, or it may refer to suppression, elimination, or attenuation of an immune response to a selected antigen. In a preferred embodiment, modulating the immune response results in stimulation/activation of an immune response to a selected antigen by about at least 5%, or preferably between 5 and 50% or more preferably between 50 and 100%, as compared to an immune response in the absence of vaccination, or it may result in suppression, elimination, or attenuation of an immune response to a selected antigen by about at least 5%, or preferably between 5 and 50% or more preferably between 50 and 100%, as compared to an immune response in the absence of vaccination. In some cases, one immune response to an antigen (e.g. a Th1 response) may be increased while another immune response to the same antigen (e.g. a Th2 response) may be diminished.
  • The invention also encompasses a composition comprising a multifunctional molecule of the invention and antigen bearing target, e.g. a virus, a prion, or a cell. Preferably, when the antigen bearing target is a cell, the multifunctional molecule is exogenous to the cell. The multifunctional molecule may be heterologous to the cell. In one embodiment, the multifunctional molecule is expressed within the cell, e.g. from a recombinant nucleic acid within the cell. The invention also encompasses a cell comprising a nucleic acid encoding a multifunctional molecule of the invention. The multifunctional molecule may have any of the characteristics set forth herein. An antigen bearing target (e.g., a cell) useful in the invention includes, for example, malignant cells, benign tumor cells, lymphocytes, e.g. B or T lymphocytes which may be pathogenic and/or autoreactive, cells expressing an antigen from an exogenously introduced nucleic acid molecule, eukaryotic cells such as mammalian cells, human cells, fibroblasts, insect and fungal cells, and prokaryotic cells such as bacterial cells. Examples of viruses useful in the invention include, e.g., retroviruses such as human immunodeficiency viruses 1 and 2; herpesviruses such as herpes simplex viruses 1 and 2, cytomegalovirus, and varicella zoster virus; human papilloma virus; rabies virus; rotavirus; influenza viruses A, B, and C; hepatitis viruses A, B, C, and E or delta agent; adenoviruses; measles virus; mumps virus; polio virus; rubella virus; parainflunza viruses; coxsackie viruses A and B; variola virus; yellow fever virus; dengue and other hemorrhagic fever viruses; West Nile fever virus; Eastern equine encephalitis virus; Western equine encephalitis virus; Venezuelan equine encephalitis virus; Japanese encephalitis virus; rhinoviruses; and foot and mouth disease virus. Prions include the agents of scrapie, kuru, and bovine spongiform encephalitis. The cell, virus, or prion may be attenuated, i.e. rendered non-pathogenic, by, e.g, killing, irradiation, chemical fixation, passaging in culture with selection for diminished pathogenicity, or genetic manipulation. Preferably, the composition further comprises a leukocyte, e.g. a monocyte, a cell of monocytic lineage, a macrophage, or a dendritic cell or another APC.
  • Preferably, in the inventive methods and compositions, the cell is substantially unable to divide in vitro. “Substantially unable to divide in vitro” means that the cell divides at a rate that is less than about 50% of the rate of division of corresponding cells which are not treated to prevent cell division. In a preferred embodiment, the cell divides at a rate that is less than about 30-50% of the rate of division of corresponding cells which are not treated to prevent cell division.
  • Preferably, the composition is substantially free of culture medium. As used herein, “culture medium” refers to medium that is used in cell culture containing at least 2% animal serum, such as fetal calf serum.
  • More particularly, the present invention provides a multifunctional molecule which is a fusion polypeptide comprising: a lectin which comprises at least about 10 contiguous amino acids of an influenza virus hemagglutinin, and at least about 5 contiguous amino acids of a naturally occurring GM-CSF molecule.
  • In one embodiment, the lectin is N-terminal to the contiguous amino acids of a naturally occurring GM-CSF molecule.
  • In an alternate embodiment, the lectin is C-terminal to the contiguous amino acids of a naturally occurring GM-CSF molecule.
  • In one embodiment, the lectin comprises at least about 10 contiguous amino acids of the HA1 domain of an influenza virus hemagglutinin.
  • In one embodiment, the lectin is the HA1 domain of an influenza virus hemagglutinin.
  • Preferably, the influenza virus hemagglutinin is a hemagglutinin of an influenza A virus. In other preferred embodiments the influenza virus hemagglutinin is a hemagglutinin of an influenza B or influenza C virus.
  • In one embodiment, the influenza virus hemagglutinin is of a subtype from a virus that infects humans. Preferably, the influenza virus hemagglutinin is of an H1 subtype. Still more preferably, the influenza virus hemagglutinin is from the influenza A strain PR/8/34.
  • In one embodiment, the influenza virus hemagglutinin is of an H2 subtype.
  • In one embodiment, the influenza virus hemagglutinin is of an H3 subtype.
  • In one embodiment, the influenza virus hemagglutinin is of a subtype from a virus that does not infect humans.
  • In one embodiment the fusion polypeptide comprises the entire amino acid sequence of a naturally occurring GM-CSF molecule.
  • Preferably, the GM-CSF molecule is a murine GM-CSF. Still more preferably, the GM-CSF molecule is a human GM-CSF.
  • In one aspect, the invention encompasses a method of reducing the number of metastases, e.g. tumor metastases, in a subject, e.g. a mammal, e.g. a human, comprising the step of administering to the subject any of the compositions described herein, e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention. Typically, such a composition will further comprise an antigen associated with the disease, or a nucleic acid encoding such an antigen. The method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein.
  • The invention provides, a method of reducing the number of metastasis in an animal comprising administering to said animal a composition comprising a cell comprising an antigen, said composition further comprising a fusion protein comprising a lectin and a ligand for a cell surface protein.
  • As used herein, a “metastasis” refers to a focus of disease that is caused by a malignent cell or infectious organism which has traveled from one site in a host to a second site in the host (e.g., from one site to a non-contiguous site; e.g., from a first organ to a second organ). More specifically, “metastasis” refers to a detectable focus of malignant tumor or infection that is derived from, and spread from, and is distinct from the primary site of disease. Accordingly, “metastases” refers to a plurality of foci either in a single organ or tissue in a subject, or in two or more organs or tissues in a subject. A “focus” as used herein may be at least a single malignant or infectious cell, or may be a detectable focus, which is detectable by one or more of the methods described hereinbelow. Metastases is said to be detected where a metastases is able to be detected by one of skill in the art using one or more of the assay methods described hereinbelow.
  • According to the invention, “reducing the number of metastases” may mean either causing there to be fewer (e.g., at least 10% fewer, 20%, 30%, 50%, 70%, 90%, and up to at least 100% fewer) metastases than expected (where the number or severity of metastases expected is based on the observations made in a set (e.g., more than one) or similar subjects which has not received the multifunctional molecule of the invention). In one embodiment “reducing the number of metastases” may encompass preventing metastases (e.g. a subject does not develop any detectable foci of disease), e.g. in a subject with a tumor, or causing one or more preexisting metastases to become undetectable, e.g. by radiologic, non-invasive imaging techniques, or other techniques as described herein. Those skilled in the art will recognize that a metastasis itself may become undetectable even though residual scarring or fibrosis may be detectable. Metastases may be, for example, to bone, brain, liver, lung, or spinal cord, or any other organ or tissue.
  • In another aspect, the invention encompasses a method of reducing the number of metastases in a population of subjects comprising the step of administering to one or more subjects any of the compositions described herein e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention. Typically, such a composition will further comprise an antigen associated with the disease, or a nucleic acid encoding such an antigen. The method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein.
  • In another aspect, the invention encompasses a method of reducing the size of a metastasis in a subject comprising the step of administering to the subject any of the compositions described herein, e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention. Typically, such a composition will further comprise an antigen associated with the disease, or a nucleic acid encoding such an antigen. The method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein. The “size” of a metastasis, as used herein refers to the one, two or three dimensional area encompassed by a metastasis, or alternatively, refers to the number of malignant or infectious cells present in a metastasis. The size of the metastasis, which may be measured by direct visualization or by noninvasive imaging, may be reduced by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%.
  • The invention provides a method of reducing the size of a metastasis in an animal comprising administering to said animal a composition comprising a cell comprising an antigen, said composition further comprising a fusion protein comprising a lectin and a ligand for a cell surface protein.
  • In another aspect, the invention encompasses a method of reducing the average size of metastases in a subject comprising the step of administering to the subject any of the compositions described herein. The method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein. According to the invention, “reducing the average size of metastases” may mean either causing metastases to be smaller on average than expected, e.g. by preventing one or more of them from growing to the expected size, or causing one or more preexisting metastases to become smaller, thus decreasing the mean size of the metastases. The average size of the metastases, which may be determined by direct visualization or by noninvasive imaging, may be reduced by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%.
  • In another aspect, the invention encompasses a method of reducing the average size of metastases in a population comprising the step of administering to one or more subjects any of the compositions described herein, e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention. The method may comprise any of the methods of administering a composition, modulating an immune response, or treating a disease described herein.
  • Thus, in another aspect the invention encompasses preventing or treating a disease in a subject by administering to the subject any of the compositions described herein, e.g. a composition comprising a multifunctional molecule of the invention or a nucleic acid molecule encoding a multifunctional molecule of the invention. Typically, such a composition will further comprise an antigen associated with the disease, or a nucleic acid encoding such an antigen. The disease may be, for example, a benign or malignant tumor, an infectious disease, an allergy, or an autoimmune disease. “Treating a disease” means decreasing morbidity or mortality associated with the disease in a patient or population afflicted with the disease. For example, survival, relapse-free survival, or disease-free survival may be prolonged by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%, or the number of metastases may be reduced by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%. For preventive applications, the incidence of the targeted disease may be reduced by, e.g., at least about 10%, at least about 20%, 30%, 50%, 70%, 90%, and up to at least 100%.
  • In yet another aspect, the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising the antigen and not comprising (i.e. free of) the multifunctional molecule administered in step 1. Generally, the two steps will be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart. In one embodiment, the composition comprising the multifunctional molecule is administered to the subject prior to the composition which is free of the multifunctional molecule. In another embodiment, the composition which is free of the multifunctional molecule is administered to the subject prior to the composition which comprises the multifunctional molecule. The antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle.
  • In yet another aspect, the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising the antigen and further comprising a nucleic acid molecule encoding a multifunctional molecule of the invention and 2) administering to the subject a composition comprising the antigen and not comprising (i.e. free of) the nucleic acid molecule administered in step 1. Again, the two steps will generally be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart. In one embodiment, the composition comprising the nucleic acid molecule is administered to the subject prior to the composition which is free of the nucleic acid molecule. In another embodiment, the composition which is free of the nucleic acid molecule is administered to the subject prior to the composition which comprises the nucleic acid molecule. The antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle. The nucleic acid molecule may be comprised by an expression vector.
  • In yet another aspect, the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and not comprising (i.e. free of) the multifunctional molecule administered in step 1. Generally, the two steps will be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart. In one embodiment, the composition comprising the multifunctional molecule is administered to the subject prior to the composition which is free of the multifunctional molecule. In another embodiment, the composition which is free of the multifunctional molecule is administered to the subject prior to the composition which comprises the multifunctional molecule. The antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle. One or more of the nucleic acid molecules may be comprised by an expression vector.
  • In yet another aspect, the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and not comprising (i.e. free of) the multifunctional molecule administered in step 1. Generally, the two steps will be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart. In one embodiment, the composition comprising the multifunctional molecule is administered to the subject prior to the composition which is free of the multifunctional molecule. In another embodiment, the composition which is free of the multifunctional molecule is administered to the subject prior to the composition which comprises the multifunctional molecule. The antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle. The nucleic acid molecule may be comprised by an expression vector.
  • In yet another aspect, the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising the antigen and not comprising (i.e. free of) the multifunctional molecule administered in step 1. Generally, the two steps will be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or a least 1 year apart. In one embodiment, the composition comprising the multifunctional molecule is administered to the subject prior to the composition which is free of the multifunctional molecule. In another embodiment, the composition which is free of the multifunctional molecule is administered to the subject prior to the composition which comprises the multifunctional molecule. The antigen of the composition may be comprised by an antigen bearing target such as a cell, a cell fraction, a virus, or a viral particle. The nucleic acid molecule may be comprised by an expression vector.
  • In yet another aspect, the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a nucleic acid molecule encoding a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and not comprising (i.e. free of) the nucleic acid molecule encoding the multifunctional molecule, which was administered in step 1. Again, the two steps will generally be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart. In one embodiment, the composition comprising the nucleic acid molecule is administered to the subject prior to the composition which is free of the nucleic acid molecule encoding the multifunctional molecule. In another embodiment, the composition which is free of the nucleic acid molecule encoding the multifunctional molecule is administered to the subject prior to the composition which comprises the nucleic acid molecule encoding the multifunctional molecule. One or more of the nucleic acid molecules may be comprised by an expression vector.
  • In yet another aspect, the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a nucleic acid molecule encoding a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a multifunctional molecule of the invention. The multifunctional molecules of step 1 and step 2 may be the same or different. Again, the two steps will generally be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or a least 1 month apart, or at least 6 months apart, or at least 1 year apart. In one embodiment, the composition comprising the nucleic acid molecule is administered to the subject prior to the composition which is free of the nucleic acid molecule encoding the multifunctional molecule. In another embodiment, the composition which is free of the nucleic acid molecule encoding the multifunctional molecule is administered to the subject prior to the composition which comprises the nucleic acid molecule encoding the multifunctional molecule. One or more of the nucleic acid molecules may be comprised by an expression vector.
  • In yet another aspect, the invention encompasses a method of modulating an immune response to an antigen in a subject, e.g. a mammal, e.g. a human, comprising the steps of 1) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a multifunctional molecule of the invention and 2) administering to the subject a composition comprising a nucleic acid molecule encoding the antigen and further comprising a nucleic acid molecule encoding a multifunctional molecule of the invention. The multifunctional molecules of step 1 and step 2 may be the same or different. Again, the two steps will generally be performed sequentially, e.g. at least 1 day apart, or at least 1 week apart, or at least 1 month apart, or at least 6 months apart, or at least 1 year apart. In one embodiment, the composition comprising the nucleic acid molecule is administered to the subject prior to the composition which is free of the nucleic acid molecule encoding the multifunctional molecule. In another embodiment, the composition which is free of the nucleic acid molecule encoding the multifunctional molecule is administered to the subject prior to the composition which comprises the nucleic acid molecule encoding the multifunctional molecule. One or more of the nucleic acid molecules may be comprised by an expression vector.
  • The present invention encompasses a method of modulating an immune response in an animal comprising the step of administering a composition comprising a multifunctional molecule, e.g. a polypeptide, e.g. a fusion polypeptide, which comprises a first part that can bind to a antigen bearing target and a second part that can bind to a cell. In a preferred embodiment, the composition further comprises an antigen, an immune response to which is modulated by administration of the composition. The antigen may be, for example, a polypeptide (e.g. a recombinant polypeptide), a lipid (e.g. a glycolipid), or a carbohydrate (e.g. a polysaccharide or a component of a bacterial or fungal cell wall). The composition therefore comprises an antigen bearing target, whether, e.g., a homogeneous antigen or a heterogeneous structure such as a cell or a virus. When the antigen bearing target is a cell, it may be autologous, syngeneic, allogeneic, or xenogeneic to the animal. In other preferred embodiments, the antigen is already present in the animal at the time the molecule is administered, and/or the antigen is administered to the animal prior to administration of the molecule. In yet another preferred embodiment, the antigen is administered to the animal after administration of the molecule.
  • Preferably, the composition comprises multifunctional molecules which are not bound to an antigen bearing target. In a preferred embodiment, the composition further comprises an antigen bearing target, e.g. a cell. In one embodiment of the invention, the composition comprises multifunctional molecules, some of which are bound to a antigen bearing target, e.g. to the surface of a cell, and some of which are external to and not bound to any target. In another embodiment, the composition comprises a multifunctional molecule and further comprises a portion of a cell, e.g. a membrane fraction of a cell (i.e., an antigen bearing target). In yet another embodiment, the composition comprises a multifunctional molecule and further comprises a multiplicity of different molecules derived from a cell, as is found, e.g., in a cell lysate. Cells may be lysed, for example, by freezing and thawing, preferably repeatedly. In a preferred embodiment, the composition is cell-free.
  • The present invention further encompasses a method of vaccinating a mammal to a selected antigen comprising administering to the animal a vaccine composition comprising a multifunctional molecule of the invention comprising a first part which is a lectin, and a second part which is a ligand for a cell surface protein, e.g. a cell surface receptor of an APC. Preferably, the lectin can bind to an antigen bearing target which comprises the antigen.
  • In one embodiment, the invention provides a method of vaccinating a mammal to a selected antigen comprising removing at least one cell from the mammal, wherein the cell comprises the antigen, contacting the cell ex vivo with a multifunctional molecule comprising a first part which is a lectin and is capable of binding to at least one carbohydrate molecule on the surface of the antigen bearing cell, and a second part which is a ligand for a cell surface protein of an APC, so as to form an antigen bearing cell/multifunctional molecule complex; and placing the complex back into the mammal.
  • In a preferred embodiment, the composition comprises an antigen, an immune response to which is modulated by administration of the composition.
  • The invention provides a method of modulating an immune response to a selected antigen in a mammal comprising administering to said animal a composition comprising a cell comprising said antigen, and a multifunctional molecule comprising a lectin and a ligand for a cell surface protein.
  • The invention also relates to a method of vaccinating an animal to a selected antigen comprising removing at least one cell from said animal, wherein the cell comprises said antigen; contacting said cell ex vivo with a fusion polypeptide comprising a lecting and a ligand for a cell surface protein of an antigen presenting cell so as to form a complex; and placing said complex back in said animal.
  • The present invention provides a method for juxtaposing an APC with an antigen bearing target comprising: contacting an APC and antigen bearing target with a multifunctional molecule comprising a first part comprising a lectin which is able to bind to at least one carbohydrate moiety on the antigen bearing target and a second part comprising a ligand for a cell surface protein on the APC. Preferably, the multifunctional molecule is first contacted with the antigen bearing target and the resulting antigen bearing target/multifunctional molecule complex is subsequently contacted with the APC. In one embodiment the antigen bearing target is a cell from an animal comprising an antigen, and is contacted with the multifunctional molecule ex vivo under conditions which permit the binding of the lectin to at least one carbohydrate moiety of the cell. The resulting multifunctional molecule/antigen bearing cell complex is then administered back to the animal from which the antigen bearing cell was derived wherein it is able to bind to a cell surface receptor on an APC via the ligand portion of the multifunctional molecule, thereby juxtaposing the antigen bearing target and the APC.
  • “Juxtaposition”, in the context of the present invention, includes but is not limited to physical contact. An APC and antigen bearing target are “juxtaposed” with one another if they are sufficiently close for the APC to internalize the antigen bearing target. An APC and antigen bearing target are also “juxtaposed” if they are separated by no more that 20 μm, preferably no more than 10 μm, and still more preferably no more than 5 μm, and more preferably no more than 1 μm.
  • As used herein, “contacting” refers to admixing in vitro or in vivo.
  • The invention also encompasses a method of modulating an immune response to an antigen comprising contacting in vitro an antigen bearing target, a multifunctional molecule of the invention, and an APC and administering the resultant composition to a subject. In one embodiment the antigen bearing target/multifunctional molecule complex is contacted with an APC for a time sufficient to permit internalization of the antigen bearing target by the APC. In other embodiments the antigen bearing target/multifunctional molecule complex is contacted with an APC for a time that allows internalization of less than about 80%, less than about 60%, less than about 40%, less than about 20%, less than about 10%, or less than about 5% of the antigen bearing target by the APC. Methods for determining the amount of target internalized, e.g. by measuring the amount remaining outside the APC and subtracting from the starting amount, are well-known in the art. Preferably, the antigen bearing target/multifunctional molecule complex is contacted with an APC for less than about 10 minutes, less than about 30 minutes, less than about 60 minutes, less than about 90 minutes, less than about 120 minutes, or less than about 180 minutes.
  • As used herein, “time sufficient to permit internalization” refers to a period of time that is of a sufficient duration to allow internalization of the selected antigen or antigen bearing targtet by the APC (for example, no more than about fourteen days, or seven days, or five or three days, or as little as about 24, 12, 6, 3, 2 or 1 hour, or even as little as about 30, 20, 10, 5, or 1 minute).
  • The invention also encompasses a method of attaching a ligand for a cell surface polypeptide to an antigen bearing target comprising admixing the antigen bearing target with a multifunctional molecule which comprises the ligand. The invention also encompasses a method of attaching an amino acid sequence to an antigen bearing target comprising admixing the antigen bearing target with a fusion polypeptide which comprises the amino acid sequence and further comprises a lectin. The invention also encompasses a composition comprising an antigen bearing target admixed with a fusion polypeptide which comprises a first amino acid sequence which is not a lectin and a second amino acid sequence which comprises a lectin.
  • The invention also comprises methods of producing a multifunctional molecule of the invention in each of the following cell types: a yeast cell, a mammalian cell, a bacterial cell, an insect cell. Each of these methods comprises the step of introducing a nucleic acid encoding a multifunctional molecule into the respective cell type, as taught hereinbelow.
  • The invention also encompasses methods of detecting or quantifying a multifunctional molecule of the invention comprising contacting the multifunctional molecule with an antibody or other ligand that binds to the multfunctional molecule. Such methods include ELISA assays and flow cytometry, as described hereinbelow. Preferably, the multifunctional molecule to be detected or quantitated is bound to an antigen bearing target.
  • DETAILED DESCRIPTION
  • The present invention is based, in part, on the discovery that a multifunctional fusion protein comprising a first polypeptide which is a lectin and a second polypeptide which is a ligand of a cell surface receptor of an APC, can effectively target an antigen bearing target, such as a cell bearing an antigen of interest, to an APC, wherein the antigen is engulfed by the APC, and an appropriate immune response to the antigen is mounted by an animal to which the multifunctional molecule is administered.
  • Accordingly, the present invention provides a method for vaccinating a mammal comprising administering to the animal a vaccine composition comprising a multifunctional molecule of the invention comprising a first part which is a lectin and which can bind to a target bearing the antigen, and a second part which is a ligand for a cell surface protein of an APC. In one embodiment, the method comprises removing at least one cell from the mammal, wherein the cell comprises the antigen, contacting the cell ex vivo with a multifunctional molecule comprising a first part which is a lectin and is capable of binding to at lease one carbohydrate molecule on the surface of the antigen bearing cell, and a second part which is a ligand for a cell surface protein of an APC, so as to form an antigen bearing cell/multifunctional molecule complex; and placing the complex back into the mammal.
  • Multifunctional Molecules
  • The present invention encompasses a multifunctional molecule comprising a first part which can bind to an antigen bearing target, and a second part which is a ligand for a cell surface protein of a cell, e.g. an antigen presenting cell. Preferably, the first part which can bind to an antigen bearing target is a lectin which binds to at least one carbohydrate molecule present on the antigen bearing target. Preferably the lectin is an influenza hemagglutinin and binds to sialic acid residues present on the antigen bearing target. Preferably, the ligand of a cell surface protein of an antigen presenting cell is selected from an opsonin, a cytokine, a ligand for a CD40 molecule, an adhesion molecule, a defensin, a heat shock protein, or a counterreceptor for a T cell costimulatory molecule. Cell surface molecules which can act as receptors for the second part of the multifunctional molecule include CD40 molecules and specific receptors for an opsonin, a cytokine, an adhesion molecule, a defensin, a heat shock protein, or a counterreceptor for a T cell costimulatory molecule, and also include, but are not limited to the cell surface molecules listed in Apendix I and II.
  • Lectins
  • The multifunctional molecule which comprises first and second parts can comprise a first part which comprises a lectin and a second part that can bind to a leukocyte, e.g. an APC, e.g. a cell of monocytic lineage or a dendritic cell (which may itself be of monocytic lineage). A “lectin”, according to the invention, is a molecule or part of a molecule, e.g. an amino acid sequence, which can bind to a carbohydrate, e.g. a polysaccharide. Families of naturally occurring lectins include:
    • 1) Galectins, a rapidly growing family of animal lectins. All of them share galactose-specificity.
    • 2) Calcium-dependent (C-type) animal lectins, an extremely large family composed of members having diverse structures and functions.
    • 3) Among this C-type lectin family, selectins form a distinguishable subfamily by their specific function in leukocyte adhesion to endothelial cells through sialyl-Lewis X recognition.
    • 4) Collectins, another subfamily of C-type lectins specific for mannose, which have a unique structure consisting of a C-type lectin domain and a collagen-like domain. They are involved in innate immunity.
    • 5) Invertebrates are known to contain various lectins in their body fluids, probably as body-protection factors. Recently, some lectins from an echinoderm were found to show hemolytic activity.
    • 6) Annexins, a group of proteins having affinity to lipids that were recently shown to be lectins showing binding to glycosaminoglycans.
    • 7) The legume lectin family, which consists of a large number of members, such as ConA, with variable saccharide specificity comparable to C-type lectins.
    • 8) Ricin, the first lectin investigated in Russia more than 100 years ago. It is now evident that the ricin family has many other homologous members which differ in either toxicity or sugar-binding specificities.
  • Thus, a multifunctional molecule of the invention may bind to one or more carbohydrates. Carbohydrates to which lectins may bind also include, for example, carbohydrates comprising lactose, D-mannose, D-glucose, D-fucose, L-fucose (e.g. alpha-L-fucose), D-galactose, blood group A oligosaccharides, blood group B oligosaccharides, saccharides comprising alpha-D-Gal(1->3)[alpha-Lfuc(1->2)]-beta-D-Gal(1->3/4-beta-D-GlcNAc, saccharides comprising alpha-sialyl-[2->3]-lactose, alpha-D-mannosyl glycoconjugates, alpha-NeuNAc-[2->6]-Gal, alpha-NeuNAc-[2->6]-GalNAc, alpha-NeuNAc-[2->3]-Gal, N-acetyl-beta-D-glucosamine, terminal alpha-D-galactosyl residues, terminal beta-D-galactosyl residues, N-acetyllactosamine, terminal alpha-D-mannosyl residues, N-acetyl-beta-D-glucosamine, terminal N-acetyl-D-galactosamine, N-acetylneuraminic acid, and terminal alpha-D-galactosaminyl residues.
  • The multifunctional molecule which comprises a lectin may comprise, for example, the whole of a naturally occurring lectin or a portion of a naturally occurring lectin, e.g about (or at least about) 5, 8, 10, 12, 15, 20, 25, 35, 50, 60, 70, 80, 100, or 120 contiguous amino acids of a naturally occurring polypeptide lectin. In one embodiment the multifunctional molecule comprises a carbohydrate-binding domain of a naturally occurring lectin, i.e., a portion of a lectin that can bind to a carbohydrate in the absence of the remainder of the lectin. In another embodiment the lectin may be non-naturally occurring, e.g. identified from an artificial library of molecules or designed by modifying the structure of a naturally occurring lectin.
  • Lectins known as “hemagglutinins” bind to carbohydrates on erythrocytes, e.g. blood group antigens, and when incubated with these cells cause them to aggregate. The influenza virus hemagglutinin, for example, binds to sialic acid. There are at least 15 known influenza hemagglutinin subtypes, defined by their distinct antigenic properties. Any of these subtypes, designated, e.g., H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, and H15, may provide amino acid sequences useful in the compositions and methods of the invention. In one embodiment of the invention, the hemagglutinin is of a subtype from a virus that infects humans, e.g. H1, H2, or H3. In another embodiment, the hemagglutinin is of a subtype from a virus that does not infect humans, e.g. one of H4 through H15. Amino acid sequences can vary up to about 20% for influenza hemagglutinins within a given subtype, and can vary between about 30% and about 70% for influenza hemagglutinins from different subtypes. Methods for determining amino acid sequence homology are known to those of skill in the art. Examples of other software that can perform sequence comparisons to determine the % identity between hemagglutanin variants (or variants of any portion of the multifunctional molecules disclosed herein) include, but are not limited to, the BLAST package (Ausubel et al., 1995, Short Protocols in Molecular Biology, 3rd Edition, John Wiley & Sons), FASTA (Atschul et al., 1990, J. Mol. Biol., 403-410) and the GENEWORKS suite of comparison tools. Both BLAST and FASTA are available for offline and online searching.
  • Although the final % homology can be measured in terms of identity, the alignment process itself is typically not based on an all-or-nothing pair comparison. Instead, a scaled similarity score matrix is generally used that assigns scores to each pairwise comparison based on chemical similarity or evolutionary distance. An example of such a matrix commonly used is the BLOSUM62 matrix the default matrix for the BLAST suite of programs. GCG Wisconsin programs generally use either the public default values or a custom symbol comparison table if supplied. It is preferred to use the public default values for the GCG package, or in the case of other software, the default matrix, such as BLOSUM62.
  • Advantageously, the BLAST algorithm is employed, with parameters set to default values. The BLAST algorithm is described in detail in Altschul et al., (1990) J. Mol. Biol. 215:403-410, which is incorporated herein by reference. The search parameters are defined as follows, and can be advantageously set to the defined default parameters.
  • Advantageously, “substantial identity” when assessed by BLAST equates to sequences which match with an EXPECT value of at least about 7, preferably at least about 9 and most preferably 10 or more. The default threshold for EXPECT in BLAST searching is usually 10.
  • BLAST (Basic Local Alignment Search Tool) is the heuristic search algorithm employed by the programs blastp, blastn, blastx, tblastn, and tblastx; these programs ascribe significance to their findings using the statistical methods of Karlin and Altschul (Karlin and Altschul 1990, Proc. Natl. Acad. Sci. USA 87:2264-68; Karlin and Altschul, 1993, Proc. Natl. Acad. Sci. USA 90:5873-7) with a few enhancements. The BLAST programs are tailored for sequence similarity searching, for example to identify homologues to a query sequence. For a discussion of basic issues in similarity searching of sequence databases, see Altschul et al (1994) Nature Genetics 6:119-129.
  • The five BLAST programs available through the National Institutes of Health (NIII; Bethesda, Md.) perform the following tasks: blastp compares an amino acid query sequence against a protein sequence database; blastn compares a nucleotide query sequence against a nucleotide sequence database; blastx compares the six-frame conceptual translation products of a nucleotide query sequence (both strands) against a protein sequence database; tblastn compares a protein query sequence against a nucleotide sequence database dynamically translated in all six reading frames (both strands); tblastx compares the six-frame translations of a nucleotide query sequence against the six-frame translations of a nucleotide sequence database.
  • BLAST uses the following search parameters:
  • HISTOGRAM—Display a histogram of scores for each search; default is yes. (See parameter H in the BLAST Manual).
  • DESCRIPTIONS—Restricts the number of short descriptions of matching sequences reported to the number specified; default limit is 100 descriptions. (See parameter V in the manual page).
  • EXPECT—The statistical significance threshold for reporting matches against database sequences; the default value is 10, such that 10 matches are expected to be found merely by chance, according to the stochastic model of Karlin and Altschul (1990). If the statistical significance ascribed to a match is greater than the EXPECT threshold, the match will not be reported. Lower EXPECT thresholds are more stringent, leading to fewer chance matches being reported. Fractional values are acceptable. (See parameter E in the BLAST Manual).
  • CUTOFF—Cutoff score for reporting high-scoring segment pairs. The default value is calculated from the EXPECT value (see above). HSPs are reported for a database sequence only if the statistical significance ascribed to them is at least as high as would be ascribed to a lone HSP having a score equal to the CUTOFF value. Higher CUTOFF values are more stringent, leading to fewer chance matches being reported. (See parameter S in the BLAST Manual). Typically, significance thresholds can be more intuitively managed using EXPECT.
  • ALIGNMENTS—Restricts database sequences to the number specified for which high-scoring segment pairs (HSPs) are reported; the default limit is 50. If more database sequences than this happen to satisfy the statistical significance threshold for reporting (see EXPECT and CUTOFF below), only the matches ascribed the greatest statistical significance are reported. (See parameter B in the BLAST Manual).
  • MATRIX—Specify an alternate scoring matrix for BLASTP, BLASTX, TBLASTN and TBLASTX. The default matrix is BLOSUM62 (Henikoff & Henikoff, 1992). The valid alternative choices include: PAM40, PAM120, PAM250 and IDENTITY. No alternate scoring matrices are available for BLASTN; specifying the MATRIX directive in BLASTN requests returns an error response.
  • STRAND—Restrict a TBLASTN search to just the top or bottom strand of the database sequences; or restrict a BLASTN, BLASTX or TBLASTX search to just reading frames on the top or bottom strand of the query sequence.
  • FILTER—Mask off segments of the query sequence that have low compositional complexity, as determined by the SEG program of Wootton & Federhen (1993) Computers and Chemistry 17:149-163, or segments consisting of short-periodicity internal repeats, as determined by the XNU program of Clayerie & States (1993) Computers and Chemistry 17:191-201, or, for BLASTN, by the DUST program of Tatusov and Lipman (NIH). Filtering can eliminate statistically significant but biologically uninteresting reports from the blast output (e.g., hits against common acidic-, basic- or proline-rich regions), leaving the more biologically interesting regions of the query sequence available for specific matching against database sequences.
  • Low complexity sequence found by a filter program is substituted using the letter “N” in nucleotide sequence (e.g., “NNNNNNNNNNN”) and the letter “X” in protein sequences (e.g., “XXXXXXXXX”).
  • Filtering is only applied to the query sequence (or its translation products), not to database sequences. Default filtering is DUST for BLASTN, SEG for other programs.
  • It is not unusual for nothing at all to be masked by SEG, XNU, or both, when applied to sequences in SWISS-PROT, so filtering should not be expected to always yield an effect. Furthermore, in some cases, sequences are masked in their entirety, indicating that the statistical significance of any matches reported against the unfiltered query sequence should be suspect.
  • NCBI-gi—Causes NCBI gi identifiers to be shown in the output, in addition to the accession and/or locus name.
  • Most preferably, sequence comparisons are conducted using the simple BLAST search algorithm provided by the NIH. In some embodiments of the present invention, no gap penalties are used when determining sequence identity.
  • Influenza hemagglutinin is expressed as a single polypeptide chain, designated HA0, which trimerizes post-translationally. HA0 is proteolytically cleaved to yield two domains, HA1 and HA2, which are disulfide-bonded to each other. HA1 comprises significant sialic acid binding activity, while HA2 is anchored to the viral membrane and facilitates fusion of this membrane with a host cell membrane. In preferred embodiments of the invention, the
  • multifunctional molecule comprising first and second parts comprises an amino acid sequence of an HA1 domain.
  • Additional examples of lectin molecules useful in the present invention include, but are not limited to, those lectins shown in Table 1, and variants thereof having at least 50%, 70%, 90%, and up to 99% sequence homology with the sequences of the lectins shown in Table 1.
    TABLE 1
    KEY NAME ABBREVIATION CLASS LECTIN CODE
     [1] /../. Quail Intestinal LECa.Ggg.Sss.xx.Xxxx.
    Lectin.
     [2] /../. Porcine Heart Lectin LECa.Ggg.Sss.xx.Xxxx.
    (PHL).
     [3] /../. Hepatic beta- S-lectin or GLTa.Ggg.Sss.xx.Xxxx.
    galactoside binding Galectin.
    lectins.
     [4] /../. Mammalian Brain S-lectin or GLTa.Ggg.Sss.xx.Xxxx.
    Beta-Galactoside- Galectin.
    binding Lectin.
     [5] Aaptos papillata. LECi.Ada.Pap.xx.Xxxx.
     [6] Abelmoschus LECp.Abe.Esc.xx.Xxxx.
    esculentus.
     [7] Abramis brana. LECp.Abr.Bra.xx.Xxxx.
     [8] Abrus precatorius. APA; APA-A; APA- beta-trefoil lectin LECp.AbrPre.se.Cga1
    C; Abrin. (APA); Type 2 (abrin)
    RIP. LECp.AbrPre.se.Cga2
    (APA).
     [10] Achatina fulica. Achatina fulica Cold LECi.Ach.ful.xx.Xsi1.
    Aggltutinin;
    achatinin-H.
     [13] Actinomyces LECf.Act.Vis.xx.Xga1.
    viscosus.
     [14] Adenia digitata. Modeccin. Type 2 RIP. LECp.AdeDig.ro.Cga1.
     [15] Adenia volksensii. Volkensin. Type 2 RIP. LECp.AdeVol.ro.Cga1.
     [16] Aegilops Hevein domain LECp.Aeg.Gen.se.Hch1.
    geniculata. lectin, chitin
    binding.
     [19] Aegopodium APA. LECp.Aeg.Pod.rh.Hga1.
    podagraria.
     [20] Aeromonas LECb.Aer.Sa1.xx.Xxxx.
    salmonicida.
     [21] Afzelia africana. LECz.Afz.Afr.xx.Xxxx.
     [22] Agardhiella tenera. LECz.Aga.Ten.xx.Xxxx.
     [23] Agaricales. LECz.Aga.sss.xx.Xxxx.
     [24] Agaricus bisporus. ABA-I, ABA-II, LECf.Aga.Bis.xx.Xga1.
    ABA-III, ABA-IV.
     [25] Agaricus blazei. LECf.Aga.Bla.xx.Xxxx.
     [26] Agaricus LECf.Aga.Cam.xx.Xxxx.
    campestris.
     [27] Agaricus edulis. LECf.Aga.Edu.xx.Xxxx.
     [28] Agrobacterium LECu.Agr.Rad.xx.Xxxx.
    radiobacter.
     [29] Agrocybe aegerita. LECf.Agr.Aeg.xx.Xxxx.
     [30] Agropyrum AREL, ARLL. Hololectin; LECp.Agr.Rep.se.Hch1
    repens. Monocot (AREL)
    mannose-binding LECp.Agr.Rep.le.Hch1
    lectins. (ARLL).
     [31] Aleuria aurantia. LECf.Ale.Aur.xx.Xfu1.
     [32] Allium AAA. Monocot LECp.All.Asc.bu.Hma1.
    ascalonicum. mannose-binding
    lectins.
     [36] Allium cepa. ACA. Monocot LECp.All.Cep.bu.Hma1.
    mannose-binding
    lectins.
     [37] Allium moly. AMA. Monocot LECp.All.Mol.bu.Hma1.
    mannose-binding
    lectins.
     [38] Allium porrum. APA. Monocot LECp.All.Por.le.Hma1.
    mannose-binding
    lectins.
     [39] Allium sativum. ASA. Monocot LECp.All.Sat.bu.Hma1
    Mannose-binding (ASA-I)
    lectin. LECp.All.Sat.bu.Hma1
    (ASA-I)
    LECp.All.Sat.bu.Hmal
    (ASA-I)
    LECp.All.Sat.bu.Hmal
    (ASA-I)
    LECp.All.Sat.bu.Hma2
    (ASA-II)
    LECp.All.Sat.le.Hma1
    (ASA-III)
    LECp.All.Sat.ro.Hma1
    (ASA-IV).
     [40] Allium ursinum. AUA-I, AUA-II, Monocot LECp.All.Urs.bu.Hma1
    AUA-III, AUA-Ir, Mannose-binding (AUA-I)
    AUA-L, AUA-Iir. lectin. LECp.All.Urs.bu.Hma2
    (AUA-II)
    LECp.All.Urs.le.Hma1
    (AUA-L)
    LECp.All.Urs.ro.Hma1
    (AUA-Ir)
    LECp.All.Urs.ro.Hma2
    (AUA-IIr).
     [42] Allium vineale. AVA. Monocot LECp.All.Vin.bu.Hma1.
    Mannose-binding
    lectin.
     [43] Allomyrina LECi.All.Dic.xx.Xxxx.
    dichotoma.
     [44] Alocasia indica. LECp.Alo.Ind.tu.Hcu1.
     [45] Aloe arborescens. Aloctin, AAA. AAA: Monocot LECp.Alo.Arb.le.?
    Mannose-binding (Aloctin-A)
    proteins Aloctin- LECp.Alo.Arb.le.Hma1
    A: u. (AAA).
     [46] Amaranthus ACA, Amaranthin, beta-trefoil lectin, LECp.Ama.Cau.se.Hga1.
    caudatus. ACL. Amaranthin
    group.
     [47] Amaranthus Amaranthin LECp.Ama.Cru.se.Hga1.
    cruentus. group.
     [48] Amaranthus AHML, Amaranthin. Amaranthin LECp.Ama.Hyp.xx.Xgal1.
    hypochondriacus. group.
     [49] Amaranthus Amaranthin LECp.Ama.Leu.se.Hga1.
    leucocarpus. group.
     [50] Amaranthus ASL. Amaranthin LECp.Ama.Spi.se.Hga1.
    spinosus. group.
     [51] Amphicarpaea ABrA. Legume lectins. LECp.Amp.Bra.se.Hma1.
    bracteata.
     [52] Anadara granosa. Anadarin MS. LECi.Ana.Gra.xx.Xsi1.
     [53] Anguilla anguilla. AAL. LECi.Ang.Ang.xx.Xfu1.
     [54] Anthocidaris Novel, unique LECi.Ant.Cra.xx.Xxxx.
    crassispina. lectin class.
     [55] Anthocidaris LECi.Ant.Cra.xx.Xxxx.
    crassispina Ovum.
     [57] Apium graveolens. LECp.Api.Gra.xx.Xxxx.
     [58] Aplysia LECi.Apl.Dac.xx.Xxxx.
    dactylomela.
     [59] Aplysia depilans. LECi.Apl.Dep.xx.Xga1.
     [60] Aplysina archeria. LECu.Apl.Arc.xx.Xxxx.
     [61] Arachis hypogea. PNA, GNL, MNL, All Arachnis LECp.Ara.Hyp.se.Hga1
    PRA-I, PRA-II. lectins are classed (PNA)
    as legume lectins. LECp.Ara.Hyp.no.Hga1
    (GNL)
    LECp.Ara.Hyp.se.Hga1
    (MNL)
    LECp.Ara.Hyp.se.Hga1
    (PRA-I)
    LECp.Ara.Hyp.se.Hga1
    (PRA-II).
     [62] Araucaria Lectin I, Lectin II. LECp.Ara.Bra.se.Hmg1
    brasiliensis. (Lectin I)
    LECp.Ara.Bra.se.Hmg2
    (Lectin II).
     [63] Arion LECi.Ari.Emp.xx.Xxxx.
    empiricorum.
     [64] Arisaema ACA. LECp.Ari.Con.tu.Hcu1.
    consanguineum.
     [65] Arisaema ACmA. LECz.Ari.Cur.tu.Hcu1.
    curvatum.
     [66] Arthrobotrys AOL. LECf.Art.Oli.xx.Xxxx.
    oligospora.
     [68] Artocarpus hirsuta. LECp.Art.Hir.xx.Xxxx.
     [69] Artocarpus incisa. LECp.Art.Inc.xx.Xxxx.
     [70] Artocarpus Jacalin, AIA, KM+, beta-prism plant LECp.Art.Int.se.Hga1.
    integrifolia. Artocarpin. lectin, Jacalin-
    related lectins.
     [71] Artocarpus Artocarpin, ALA-I, Jacalin-related LECp.Art.Lak.se.Hga1.
    lakoocha. ALA-II. lectins.
     [72] Arum maculatum. AMA. Monocot binding LECp.Aru.Mac.tu.Hma1.
    lectins.
     [73] Ascaris LECi.Asc.Lum.xx.Xxxx.
    lumbricoides.
     [74] Asparagus LECp.Asp.Off.xx.Xxxx.
    officinalis.
     [75] Bacillus LECb.Bac.Pols.xx.Xxxx.
    polymyxa.
     [76] Bacterioides LECb.Bac.Fra.xx.Xxxx.
    fragilis.
     [77] Bandeiraea BS-I, BS-I-A4, BS-I- LECp.Ban.Sim.xx.Xxxx.
    simplicifolia. B4, BS-II.
     [78] Basidiomycotina. LECf.Bas.Sss.xx.Xxxx.
     [79] Bauhinia purpurea. BPA. Legume lectin. LECp.Bau.Pur.se.Hga1.
     [80] Bauhinia LECz.Bau.Tom.xx.Xxxx.
    tomentosa.
     [81] Beauveria LECf.Bea.Bas.xx.Xsi1.
    bassiana.
     [82] Beta vulgaris. LECp.Bet.Vul.xx.Xxxx.
     [83] Beta vulgaris. LECp.Bet.Vul.xx.Xxxx.
     [84] Biomphalaria BGL-I, BGL-II. LECp.Bio.Gla.xx.Xxxx.
    glabrata.
     [85] Biomphalaria LECi.Bio.Gla.xx.Xxxx.
    glabrata.
     [86] Birgus latro. LECz.Bir.Lat.xx.Xxxx.
     [87] Blaberus BDL1, BDL2, BDL3. LECi.Bla.Dis.xx.Xxxx.
    discoidalis.
     [88] Bordetella Pertussis toxin 1PRT. LECz.Ggg.Sss.xx.Xxxx.
    pertussis.
     [89] Bos Taurus. Mannose 6-phosphate P-lectin. LECa.Bos.Tau.xx.Xxxx.
    receptor (1C39).
     [90] Bos taurus. Bovine Conglutinin. C-lectin or LECa.Bos.Tau.xx.Xxxx.
    Collectin.
     [91] Bos taurus. Bovine collectin-43 C-lectin or Leca.Bos.Tau.xx.Xxxx.
    (CL-43). Collectin.
     [92] Botryllus S-lectin. LECi.Bot.Sch.xx.Xxxx.
    schlosseri.
     [93] Botrytis cinerea. LECz.Bot.Cin.xx.Xxxx.
     [94] Bowringia BMA. Legume lectins. LECp.Bow.Mil.se.Hmg1.
    milbraedii.
     [95] Brachypodium BsyL. Chitin-binding LECp.Bra.Syl.se.Hch1.
    sylvaticum. lectins.
     [96] Bradyrhizobium LECp.Bra.Jap.xx.Xga1.
    japonicum.
     [97] Branchiostoma LECi.Bra.Lan.xx.Xxxx.
    lanceolatum.
     [98] Brassica LECp.Bra.Cam.xx.Xxxx.
    campetsris.
     [99] Brassica LECp.Bra.Nap.xx.Xxxx.
    napobrassica.
    [100] Brassica napus. LECp.Bra.Nap.xx.Xxxx.
    [101] Bryonia dioica. BDA. LECp.Bry.Dio.tu.Hga1.
    [113] Cancer LECi.Can.Ant.xx.Xsi1.
    antennarius.
    [114] Candida albican Adhesins. LECf.Can.Alb.xx.Xfu1.
    adhesin.
    [115] Canna generalis. LECp.Can.Gen.rh.Hma1.
    [116] Capnocytophaga LECu.Cap.Gin.xx.Xxxx.
    gingivalis
    Actinomyces
    Israelii
    Coaggregation
    agglutinin.
    [117] Capsicum annum. LECp.Cap.Ann.xx.Xxxx.
    [118] Caragana CAA-I, CAA-II. LECp.Car.Arb.se.Hga1
    arborescens. (CAA-I)
    LECp.Car.Arb.se.Hga2
    (CAA-II).
    [119] Carcharhinus LECa.Car.Spr.xx.Xxxx.
    springeri.
    [120] Carcinoscorpious L10; carcinoscorpin. LECi.Car.Rot.xx.Xsi1.
    rotundacauda.
    [121] Carica papya. LECp.Car.Pap.xx.Xxxx.
    [123] Carum carvia. LECp.Car.Car.xx.Xxxx.
    [124] Carybdea alata LECi.Car.Ala.xx.Xxxx.
    Hemolysin.
    [125] Castanea crenata. CCA. LECp.Cas.Cre.xx.Xxxx.
    [126] Cepaea hortensis. CHA-I. LECi.Cep.Hor.xx.Xxxx.
    [127] Channa punctatus. LECa.Cha.Pun.xx.Xxxx.
    [129] Chelidonium LECp.Che.Maj.se.Hch1.
    majus.
    [132] Chicorium LECp.Chi.Int.xx.Xxxx.
    intybus.
    [133] Cholla opuntia. LECp.Cho.Opu.xx.Xxxx.
    [134] Cicer arietinum. CAA. LECp.Cic.Ari.se.Hcu1.
    [135] Cinachyrella LECi.Cin.All.xx.Xxxx.
    alloclada.
    [136] Cinnamonum LECp.Cin.Cam.xx.Xxxx.
    camphora.
    [137] Citrullus vulgaris. LECp.Cit.Vul.xx.Xxxx.
    [139] Citrus aurantium. LECp.Cit.Aur.se.Cnd1.
    [140] Citrus aurantium. LECp.Cit.Aur.xx.Xxxx.
    [141] Citrus medica. LECp.Cit.Med.xx.Xxxx.
    [142] Cladrastis lutea. CLA-I, CLA-II. LECp.Cla.Lut.ba.Hmg1
    (CLA-I)
    LECp.Cla.Lut.ba.Hmg2
    (CLA-II).
    [143] Clerodendron CTA. LECp.Cle.Tri.fr.Hga1.
    trichotomum.
    [144] Clitocyba LECf.Cli.Neb.xx.Xxxx.
    nebularis.
    [145] Clivia miniata. CMA. LECp.Cli.Min.le.Hma1.
    [146] Clostridium LECb.Clo.Bot.xx.Xxxx.
    botulinum.
    [147] Clostridium tetani. Tetanus toxin LECb.Ggg.Sss.xx.Xxxx.
    (1A8D).
    [148] Clupea harengus. LECa.Clu.Har.xx.Xxxx.
    [149] Coccinia grandis. CIA. LECp.Coc.Gra.fr.Hch1.
    [151] Cocus nucifera. LECp.Coc.Nuc.xx.Xxxx.
    [152] Codium fragilis. LECu.Cod.Fra.xx.Xxxx.
    [153] Cofea arabica. LECp.Cof.Ara.xx.Xxxx.
    [154] Colchicum CAA. LECp.Col.Aut.bu.Hcu1.
    autumnale.
    [155] Collybia velutipes. LECf.Col.Vels.xx.Xxxx.
    [156] Colocasia CEA. LECp.Col.Esc.tu.Hma1.
    esculentum.
    [157] Conger myriaster. Congerin I, Congerin S-lectin. LECi.Con.Myr.xx.Xga1.
    II.
    [159] Conidiobolus LECf.Con.Obs.xx.Xga1.
    obscurus.
    [160] Coprinus cinereus. Cg1, Cg2. Galectin. LECf.Cop.Cin.xx.Xxxx.
    [161] Corbicula LECi.Cor.Flu.xx.Xxxx.
    fluminea
    Hemolysin.
    [163] Corylus avellania. LECp.Cor.Ave.xx.Xxxx.
    [164] Cratylia mollis. LECz.Cra.Mol.xx.Xxxx.
    [165] Crenomytilus CGL. LECi.Cre.Gra.xx.Xxxx.
    grayanus.
    [166] Crocus sativum. LECp.Cro.Sat.bu.Hma1.
    [167] Crocus vernus. CVA. LECp.Cro.Ver.xx.Xxxx.
    [169] Crotalaria striata. LECp.Cro.Str.se.Hga1.
    [170] Crotolaria LECz.Cro.Aeg.xx.Xxxx.
    aegyptica.
    [171] Crotolaria falcata. LECz.Cro.Fal.xx.Xxxx.
    [172] Crotolaria juncea. LECp.Cro.Jun.se.Hga1.
    [174] Croton tiglium. LECp.Cro.Tig.se.Hcu1.
    [175] Cucumaria CEL-III. LECi.Cuc.Ech.xx.Xxxx.
    echinata.
    [176] Cucumis LECp.Cuc.Cat.xx.Xxxx.
    catalupensis.
    [177] Cucumis melo. LECp.Cuc.Mel.xx.Xch1.
    [178] Cucumis sativus. LECp.Cuc.Sat.xx.Xch1.
    [180] Cucurbita ficifolia. LECp.Cuc.Fic.xx.Xxxx.
    [181] Cucurbita maxima. CMA, PP2. LECp.Cuc.Max.ps.Hch1.
    [182] Cucurbita pepe. LECp.Cuc.Pep.xx.Xxxx.
    [183] Cucurbita pepo. CPA. LECp.Cuc.Pep.fr.Hch1.
    [184] Cucurbita sativus. LECp.Cuc.Sat.xx.Xxxx.
    [185] Cydonia oblonja. LECp.Cyd.Obl.xx.Xxxx.
    [186] Cymbidium LECz.Cym.Hyb.le.Hma1.
    hybrid.
    [187] Cyphomandra LECp.Cyp.Bet.xx.Xxxx.
    betacea.
    [188] Cytisis CMA-I, CMA-II. LECp.Cyt.Mul.se.Hch1
    multiflorus. (CMA-I)
    LECp.Cyt.Mul.se.Hfu1
    (CMA-II).
    [189] Cytisus scoparius. CSA-I, CSA-II, LECp.Cyt.Sco.se.Hga1
    CMH-I, CMH-II. (CS-I)
    LECp.Cyt.Sco.se.Hga2
    (CS-II).
    [190] Cytisus LECp.Cyt.Ses.se.Hch1
    sessilfolius. (CSA-I)
    LECp.Cyt.Ses.se.Hga1
    (CSA-II).
    [191] Dacrymycetales. LECz.Dac.sss.xx.Xxxx.
    [192] Dalbergia. LECz.Dal.sss.xx.Xxxx.
    [193] Datura innoxia. LECp.Dat.Inn.xx.Xxxx.
    [194] Datura DSA. Chitin-bindng LECp.Dat.Str.se.Hch1.
    stramonium. lectins.
    [195] Daucus carrota. LECp.Dau.Car.xx.Xxxx.
    [196] Dendroaspis JML, Jameson's LECi.Den.Jam.xx.Xga1.
    jamesoni. Mamba Venon.
    [198] Deuteromycetes. LECz.Deu.sss.xx.Xxxx.
    [199] Dicolea lehmani. LECz.Dio.Leh.xx.Xxxx.
    [200] Dictyostelium Discoidin I. LECu.Dic.Dis.xx.Xxxx.
    discoideum.
    [201] Dictyostelium Purpurin. LECu.Dic.Pur.xx.Xxxx.
    purpureum.
    [202] Didemnum DTL, DCL-I, DCL- LECi.Did.Sss.xx.Xga1.
    candidum. II.
    [203] Dieffenbachia LECp.Dif.Seq.xx.Xxxx.
    sequina.
    [204] Dioclea Legume lectin. LECp.Dio.Gra.xx.Xxxx.
    grandifolia.
    [205] Dioclea DLL-I, DLL-II, Legume lectin. LECp.Dio.Gui.xx.Xmg1.
    guianensis. DLL-III.
    [206] Dioclea virgata. Legume lectin. LECz.Dio.Vir.xx.Xxxx.
    [207] Dolichos biflorus. DBA-S, DBA-R, Legume lectin. LECp.Dol.Bif.se.Hga1
    DB-58, DB-57, (DBA)
    DB46. LECp.Dol.Bif.pl.Hcu1
    (DB58)
    LECp.Dol.Bif.pl.Hcu2
    (DB57)
    LECp.Dol.Bif.ro.?ga1
    (DB46).
    [208] Drosophila. LECi.Dro.Meg.xx.Xxxx.
    [209] Dumasia. LECz.Dum.sss.xx.Xxxx.
    [210] Echinocereus LECp.Echi.Eng.xx.Xxxx.
    engelmanii.
    [211] Echis EMS16. LECi.Ech.Mul.xx.Xxxx.
    multisquamatus.
    [212] Electrophorus Electrolectin. LECi.Ele.Ele.xx.Xxxx.
    electricus.
    [213] Elymus Hevein domain LECp.Ely.Can.se.Hch1.
    canadensis. lectin, chitin
    binding.
    [223] Erythrina velutina. LECp.Ery.Vel.xx.Xxxx.
    [224] Escherichia coli. Pili mannose-specific Verotoxin-1: LECb.Ech.Col.xx.Xxxx.
    FimH adhesin ADP-ribosylating
    (1QUN),. toxins.
    [225] Euhadra LECz.Euh.Cal.xx.Xxxx.
    callizoma.
    [226] Euphorbia LECp.Eup.Sss.xx.Xxxx.
    characias.
    [227] Euphorbia LECp.Eup.Het.xx.Xga1.
    heterophylla.
    [228] Evonymus LECp.Evo.Eur.se.Hcu1.
    europaea.
    [229] Falcata japonica. LECp.Fal.Jap.se.Hga1.
    [230] Ficus cunia. LECp.Fic.Cun.xx.Xxxx.
    [231] Flammulina LECf.Fla.Vel.xx.Xxxx.
    veltipes.
    [232] Fomes LECz.Fom.Fom.xx.Xxxx.
    fomentarius.
    [233] Fragaria vesca. LECp.Fra.Ves.xx.Xxxx.
    [234] Fucus serratus. LECu.Fuc.Ser.xx.Xxxx.
    [235] Fucus vesiculosis. LECu.Fuc.Ves.xx.Xxxx.
    [236] Galactia tashiroi. LECp.Gal.Tas.se.Hga1.
    [237] Galactia LECp.Gal.Ten.se.Hga1.
    tenuiflora.
    [238] Galanthus nivalis. Monocot lectin. LECp.Gal.Niv.bu.Hma1.
    [239] Galleria LECi.Gal.Mel.xx.Xxxx.
    mellonella.
    [240] Gallus gallus. GGL. S-lectin or GLTa.Gal.Gal.xx.Xxxx.
    Galectin.
    [241] Gallus gallus. Chicken Hepatic LECa.Gal.Gal.xx.Xxxx.
    lectins (CHL).
    [242] Gallus gallus. Chicken egg LECa.Gal.Gal.xx.Xxxx.
    agglutinins.
    [243] Gallus gallus. Chick Beta- S-lectin or LECa.Gal.Gal.xx.Xxxx.
    galactoside-Binding Galectin.
    lectins.
    [244] Gallus gallus. Chicken Serum C-lectin or LECa.Gal.Gal.xx.Xxxx.
    Mannose-Binding Collectin.
    Protein.
    [245] Gallus gallus. Chicken Liver C-lectin or LECa.Gal.Gal.xx.Xxxx.
    Mannose-Binding Collectin.
    Protein.
    [246] Gallus gallus. Chicken Thymic S-lectin or GLTa.Gal.Gal..xx.Xxxx.
    Electrolectin (CTE). Galectin.
    [247] Gallus gallus. Chick Embryonic S-lectin or GLTa.Gal.Gal.xx.Xxxx.
    Skin Lectins. Galectin.
    [248] Genypterus LECi.Epi.Tre.xx.Xxxx.
    blacodes.
    [249] Geodia cydonium. LECi.Geo.Cyd.xx.Xga1.
    [250] Giardia lambia Taglin. LECu.Gia.Lam.xx.Xxxx.
    Surface lectin.
    [251] Gliricida sepium. Lectin A, Lectin B. LECp.Gli.Sep.se.Hga1
    (Lectin A)
    LECp.Gli.Sep.se.Hga2
    (Lectin B).
    [252] Glossina LECi.Glo.Lon.xx.Xxxx.
    longipennis lectin.
    [253] Glycine max. SBA. Legume lectin. LECp.Gly.Max.se.Hga1.
    [254] Gonatanthus LECz.Gon.Pum.ti.Hcu1.
    pumilus.
    [256] Grateulopia LECu.Gra.Fil.xx.Xxxx.
    filicina.
    [257] Griffithsia LECu.Gri.Flo.xx.Xxxx.
    flosculosa.
    [258] Griffonia GS-I-A4, GS-I-A4, Legume lectin. LECp.Gri.Sim.se.Hga1
    Simplicifolia GS-I-B4, GS-II, GS-IV. (GS-I-A4)
    lectins. LECp.Gri.Sim.se.Hga2
    (GS-I-B4)
    LECp.Gri.Sim.se.Hch1
    (GS-II)
    LECp.Gri.Sim.se.Hfu1 (GS-
    IV) LECp.Gri.Sim.le.Hga1
    (GS-I-A4)
    LECp.Gri.Sim.le.Hga2 (GS-
    I-B4)
    LECp.Gri.Sim.le.Hch1 (GS-
    II) LECp.Gri.Sim.le.Hfu1
    (GS-IV).
    [260] Grifola frondosa. GFL. LECf.Gri.Fro.xx.Xga1.
    [261] Haemonchus LECz.Xxx.Xxx.xx.Xxxx.
    contortus.
    [262] Halidrys siliquosa. LECu.Hal.Sil.xx.Xxxx.
    [263] Halimeda opuntia. LECu.Hal.Opu.xx.Xxxx.
    [264] Halocynthia LECi.Hal.Pyr.xx.Xxxx.
    pyriformis.
    [265] Halocynthia LECi.Hal.Ror.xx.Xga1.
    roretzi.
    [266] Haynaldia villosa. Hevein domain LECp.Hay.Vil.se.Hch1.
    lectin, chitin
    binding.
    [269] Helianthus annus. beta-prism plant LECp.Hel.Ann.xx.Xxxx.
    lectin.
    [270] Helianthus HTA. Jacalin-related LECp.Hel.Tub.tu.Hmmm1.
    tuberosus. lectins.
    [271] Helicobacter HP-SAL. LECb.Hel.Pyl.xx.Xxxx.
    pylori.
    [272] Helix aspersa. LECi.Hel.Asp.xx.Xxxx.
    [273] Helix pomatia. HPA. LECi.Hel.Pom.xx.Xxxx.
    [274] Herpetomonas. LECz.Her.xx.Xxxx.
    [276] Heteranthelium Hevein domain LECp.Het.Pil.se.Hch1.
    piliferum. lectin, chitin
    binding.
    [277] Heterometrus LECi.Het.gra.xx.Xsi1.
    granulomanus.
    [279] Hevea brasiliensis. HBA, Hevein. Chitin-binding LECp.Hev.Bra.la.Mch1.
    lectin with hevein
    domain.
    [280] Hippeastrum HHA. Monocot lectin. LECp.Hip.Hyb.bu.Hma1.
    hybrid.
    [281] Hippopus Tridacnin. C-lectin. LECi.Hip.Hip.xx.Xxxx.
    hippopus.
    [282] Hizoctonia solani. LECz.Hiz.Sol.xx.Xxxx.
    [283] Hohenbuehelia LECf.Hoh.Ser.xx.Xxxx.
    serotina.
    [284] Homarus HAA. LECi.Hom.Ame.xx.Xxxx.
    americanus.
    [285] Homo sapiens. P-selectin (1KJD). C-lectin. LECh.Hom.Sap.xx.Xxxx.
    [286] Homo sapiens. Human Mannose C-lectin. LECh.Hom.Sap.xx.Xxxx.
    Binding Protein
    (MBP) (1HUP).
    [287] Homo sapiens. Gut Mucus Anti- LECh.Hom.Sap.xx.Xxxx.
    Salmonella Lectin.
    [288] Homo sapiens. Human Membrane LECh.Hom.Sap.Xxxx.
    Lectins (HKML,
    HCCML).
    [289] Homo sapiens. Human Synovial LECh.Hom.Sap.xx.Xxxx.
    Tissue Lectins.
    [290] Homo sapiens. Human Placenta LECh.Hom.Sap.xx.Xxxx.
    Lectins (HPL-H,
    HPL-BG).
    [291] Homo sapiens. Human Brain LECh.Hom.Sap.xx.Xxxx.
    Galactoside-binding
    Lectin.
    [292] Homo sapiens. Human 14-kDa LECh.Hom.Sap.xx.Xxxx.
    Lectins.
    [293] Homo sapiens. Human Core-specific LECh.Hom.Sap.xx.Xxxx.
    Lectin (HCSL).
    [294] Homo sapiens. Cell Membrane LECh.Hom.Sap.xx.Xxxx.
    Lectins.
    [295] Homo sapiens. Tumoricidal LECh.Hom.Sap.xx.Xga1.
    Macrophage Lectin.
    [296] Homo sapiens. Tumor-associated LECa.Ggg.Sss.xx.Xxxx.
    Vertebrate Lectin.
    [297] Homo sapiens. Human Conglutinin- LECh.Hom.Sap.xx.Xxxx.
    like Protein.
    [298] Homo sapiens. Mannose-Specific LECh.Hom.Sap.xx.Xma1.
    Endocytosis
    Receptor.
    [299] Homo sapiens. Human Penultimate LECh.Hom.Sap.xx.Xxxx.
    Galactose Lectin.
    [300] Homo sapiens. Thrombospondin. LECh.Hom.Sap.xx.Xxxx.
    [301] Homo sapiens. Tetranectin. LECh.Hom.Sap.xx.Xxxx.
    [302] Homo sapiens. Human Dendritic LECh.Hom.Sap.xx.Xxxx.
    Cell Immunoreceptor
    (DCIR).
    [303] Homo sapiens. Human Seminal LECh.Hom.Sap.xx.Xxxx.
    Lectin (HSL).
    [304] Homo sapiens. Charcot-Leyden S-lectin or GLTh.Hom.Sap.xx.Xxxx.
    crystal protein Galectin.
    (1LCL).
    [305] Homo sapiens. Galectin II L-14-II Proto S-lectin or GLTh.Hom.Sap.xx.Xxxx.
    (1HLC). Galectin.
    [306] Homo sapiens. Human Lung C-lectin or GLTh.Hom.Sap.xx.Xxxx.
    Surfactant Protein Collectin.
    (1B08).
    [307] Homo sapiens. Galectin III. Chimera S-lectin GLTh.Hom.Sap.xx.Xxxx.
    or Galectin.
    [308] Homo sapiens. Galectin VII, hGal-7. Proto S-lectin or GLTh.Hom.Sap.xx.Xxxx.
    Galectin.
    [309] Homo sapiens. Pentraxin(1CRV). Pentraxin, S- GLTh.Hom.Sap.xx.Xxxx.
    lectin or Galectin.
    [310] Homo sapiens. Sialoadhesin. I-lectin. LECz.Ggg.Sss.xx.Xxxx.
    [311] Homo sapiens. Serum Amyloid P Pentraxin. LECh.Hom.Sap.xx.Xxxx.
    Component.
    [312] Homo sapiens. E-Selectin (1ESL). C-lectin. SELh.Hom.Sap.xx.Xxxx.
    [313] Homo sapiens. L-Selectin (1KJB). C-lectin. SELh.Hom.Sap.xx.Xxxx.
    [314] Homo sapiens. C-Reactive protein Pentraxin, S- GLTh.Hom.Sap.xx.Xxxx.
    (1CRV). lectin or Galectin.
    [315] Homo sapiens. Galectin XII. S-lectin or GLTh.Hom.Sap.xx.Xxxx.
    Galectin.
    [316] Homo sapiens. Galectin I. Proto S-lectin or GLTh.Hom.Sap.xx.Xxxx.
    Galectin.
    [317] Homo sapiens. Galectin IX, Tandem Repeat GLTh.Hom.Sap.sr.Xxxx.
    Ecalectin. S-lectin or
    Galectin.
    [318] Homo sapiens. Galectin VIII. Tandem Repeat GLTh.Hom.Sap.xx.Xxxx.
    S-lectin or
    Galectin.
    [319] Homo sapiens. Galectin IV. Tandem Repeat GLTh.Hom.Sap.xx.Xxxx.
    S-lectin or
    Galectin.
    [320] Homo sapiens. Alpha-1/Beta-1 Integrin A (or I) INTh.Hom.Sap.xx.Xxxx.
    integrin. domain.
    [321] Homo sapiens. Alpha-2/Beta-1 Integrin A (or I) INTh.Hom.Sap.xx.Xxxx.
    integrin. domain.
    [322] Homo sapiens. Alpha-3/Beta-1 Integrin A (or I) INTh.Xxx.Xxx.xx.Xxxx.
    integrin. domain.
    [323] Homo sapiens. Alpha-4/Beta-1 Integrin A (or I) INTh.Xxx.Xxx.xx.Xxxx.
    integrin. domain.
    [338] Homo sapiens. Alpha-5/Beta-8 Integrin A (or I) INTh.Hom.Sap.xx.Xxxx.
    integrin. domain.
    [339] Homo sapiens. Alpha-4/Beta-7 Integrin. INTh.Hom.Sap.xx.Xxxx.
    Integrin.
    [340] Homo sapiens. Alpha-E/Beta-7. Integrin. INTh.Hom.Sap.xx.Xxxx.
    [341] Homo sapiens. Mucosal addressin Addressin. LECh.Xxx.Xxx.xx.Xxxx.
    cell adhesion
    molecule-1
    (MADCAM-1).
    [342] Homo sapiens. Vascular Adhesion LECh.Xxx.Xxx.xx.Xxxx.
    Molecule (VCAM-1.
    [343] Homo sapiens. P-Selectin. Selectin. SELh.Xxx.Xxx.xx.Xxxx.
    [344] Homo sapiens. Intercellular Addressin?. LECh.Xxx.Xxx.xx.Xxxx.
    Adhesion Molecule
    (ICAM-1, ICAM-2).
    [345] Homo sapiens. Peripheral Lymph Addressin. LECh.Xxx.Xxx.xx.Xxxx.
    Node Addressin
    (PNAd).
    [346] Homo sapiens. Vascular Adhesion LECh.Xxx.Xxx.xx.Xxxx.
    Protein (VAP-1).
    [347] Homo sapiens. LFA-3. Addressin?. LECh.Xxx.Xxx.xx.Xxxx.
    [348] Homo sapiens. Versican. Soluble C-lectin LECh.Xxx.Xxx.xx.Xxxx.
    (‘Lecticans’).
    [349] Homo sapiens. Aggrecan. Soluble C-lectin LECh.Xxx.Xxx.xx.Xxxx.
    (‘Lecticans’).
    [350] Homo sapiens. Neurocan. Soluble C-lectin LECh.Xxx.Xxx.xx.Xxxx.
    (‘Lecticans’).
    [351] Homo sapiens. Brevican. Soluble C-lectin LECh.Xxx.Xxx.xx.Xxxx.
    (‘Lecticans’).
    [352] Homo sapiens. Annexin V. Annexin. ANNh.Hom.Sap.xx.Xxx5.
    [353] Homo sapiens. Annexin II. Annexin. ANNh.Hom.Sap.xx.Xxx2.
    [354] Homo sapiens. Annexin IV. Annexin. ANNh.Hom.Sap.xx.Xxx4.
    [355] Homo sapiens. Annexin I Annexin. ANNh.Hom.Sap.xx.Xxx1.
    (Lipocortin-1),
    ANX1.
    [356] Homo sapiens. Annexin VII, ANNh.Hom.Sap.xx.Xxx7.
    Synexin.
    [357] Homo sapiens. Activated Leukocyte LECh.Hom.Sapxx.
    Adhesion Molecule
    (ALCAM).
    [358] Homo sapiens. E-cadherin. CDHh.Hom.Sap.xx.XxxE.
    [360] Homo sapiens. N-cadherin CDHh.Hom.Sap.xx.XxxN.
    (uvomorulin).
    [361] Homo sapiens. VE-cadherin CDHh.Hom.Sap.xx.XxxVE.
    (Vascular Endothelial
    Cadherin).
    [362] Homo sapiens. P-cadherin. CDHh.Hom.Sap.xx.XxxP.
    [363] Homo sapiens. Annexin XI (CAP- ANNh.Hom.Sap.xx.Xxx9.
    50).
    [364] Homo sapiens. Endothelial Cell- CDHh.Hom.Sapxxx.
    Selective Adhesion
    Molecule (ESAM).
    [365] Homo sapiens. ELAM-1. CDHh.Xxx.Xxx.xx.Xxxx.
    [366] Homo sapiens. GMP-140. CDHh.Xxx.Xxx.xx.Xxxx.
    [367] Homo sapiens. Cutaneous LECh.Xxx.Xxx.xx.Xxxx.
    Lymphocyte Antigen
    (CLA).
    [369] Homo sapiens. Lymphocyte LECh.Xxx.Xxx.xx.Xxxx.
    Function-Associated
    Antigen-1 (LFA-1).
    [370] Homo sapiens. Very Late Antigen 4 LECh.Xxx.Xxx.xx.Xxxx.
    (VLA-4).
    [371] Hordeum vulgare. HVA. LECp.Hor.Vul.se.Hch1.
    [372] Hura crepitans. HCA. Type 2 RIP. LECp.Hur.Cre.se.Cga1
    (HCA)
    LECp.Hur.Cre.la.Cga1.
    [373] Hygrophorus LECf.Hyg.Hyp.xx.Xxxx.
    hypothejus.
    [374] Hypnea LECu.Hyp.Cer.xx.Xxxx.
    cervicornis.
    [375] Hyptos LECz.Hyp.Sua.xx.Xxxx.
    suaveolens.
    [376] Iberis amara. LECp.Ibe.Ama.xx.Xxxx.
    [377] Influenza virus. Hemagglutinin. Hemagglutinin. LECv.Inf.Vir.xx.Xxxx.
    [378] Ipomoea batatas. LECp.Ipo.Bat.xx.Xxxx.
    [379] Iris hollandica. LECp.Iri.Hol.xx.Xxxx.
    [380] Iris hybrid. IRA. Type 2 RIP. LECp.Iri.Hyb.bu.Cga1.
    [381] Juglans regia. LECp.Jug.Reg.xx.Xxxx.
    [382] Klyveromyces LECz.Kly.Bul.xx.Xxxx.
    bulgaricus.
    [383] Kuehneromyces LECu.Kue.Mut.xx.Xxxx.
    mutabilis.
    [384] Labiaceae LECp.Lab.Ori.xx.Xxxx.
    origanum.
    [385] Lablab purpureus. DLA, LPA. Legum lectin. LECp.Lab.Pur.se.Hmg1.
    [386] Laburnum LAA-I, LAA-II. Legume lectin. LECp.Lab.Alp.se.Hch1
    alpinum. (LAA-I)
    LECp.Lab.Alp.se.Hga1
    (LAA-II).
    [387] Laccaria LECz.Lac.Ame.xx.Xxxx.
    amethystina.
    [389] Lachesis huta. BML. LECi.Lac.Jut.xx.Xxxx.
    [390] Lactarius LDL. LECf.Lac.Del.xx.Xgal1.
    deliciosus.
    [391] Lactarius LECz.Lac.Lig.xx.Xxxx.
    lignyotus.
    [392] Lactuca scariole. PLA-I, PLA-II. LECa.Lac.Sca.xx.Xxxx.
    [393] Laelia autumnalis. LECp.Lae.Aut.xx.Xxxx.
    [394] Laetiporus PSL. LECf.Lae.Sul.xx.Xxxx.
    sulfureus.
    [395] Lathyrus cicera. LcLI, LcLII. LECp.Lat.Cic.xx.Xxxx.
    [396] Lathyrus nissolia. LECp.Lat.Nis.xx.Xxxx.
    [397] Lathyrus ochrus. LOL-I, LOL-II. Legume lectin. LECp.Lat.Och.xx.Xxxx.
    [398] Lathyrus odoratus. LECp.Lat.Odo.xx.Xxxx.
    [399] Lathyrus silvestris. LECp.Lat.Sil.xx.Xxxx.
    [400] Lathyrus LECp.Lat.Tub.xx.Xxxx.
    tuberosus.
    [401] Lens culinaris. LCA, LcH. Legume lectins. LECp.Len.Cul.se.Hmg1.
    [402] Lepidium LECp.Lep.Sat.xx.Xxxx.
    sativuum.
    [403] Leptonychotes LECz.Lep.Wed.xx.Xxxx.
    weddelli.
    [404] Leptospermum LAA. LECp.Lep.Arc.xx.Xxxx.
    archinoides.
    [405] Leucojum. LECz.Leu.sss.xx.Xxxx.
    [406] Leucojum LAA. Monocot LECp.Leu.Aes.bu.Hma1.
    aestivum. mannose-binding
    lectins.
    [407] Leucojum vernum. LVA. Monocot LECp.Leu.Ver.bu.Hma1.
    mannose-binding
    lectins.
    [408] Limulus Limulin. Pentraxin. LECi.Lim.Pol.xx.Xsi1.
    polyphemus.
    [409] Liocarcinus LECi.Lio.Dep.xx.Xxxx.
    depurator.
    [410] Listeria ovata. LOA, LOMBP. Monocot LECp.Lis.Ova.le.Hma1
    mannose binding (LOA)
    proteins. LECp.Lis.Ova.le.Mma1
    (LMOBP).
    [411] Litchi chinensis. LCL. LECp.Lit.Chi.xx.Xxxx.
    [412] Lonchocarpus Legume lectin. LECp.Lon.Cap.se.Hga1.
    capassa.
    [413] Lontonis bainesii. Legum lectins. LECp.Lon.Bai.se.Hga1
    LECp.Lon.Bai.ro.Hga1.
    [414] Lophocereus LECp.Lop.Sho.xx.Xxxx.
    shotti.
    [415] Lotus LTA. Legume lectins. LECp.Lot.Tet.se.Hfu1.
    tetragonolobus.
    [416] Luffa acutangula. LAA. Cucurbtaceae LECp.Luf.Acu.fr.Hch1.
    phloem lectins.
    [417] Lumbricus EW29. LECi.Lum.Ter.xx.Xxxx.
    terrestris.
    [418] Lycopersicon LEA, TL, LEL. Chitin-binding LECp.Lyc.Esc.fr.Hch1.
    esculentum. lectins.
    [419] Lycoris aurea. Monocot LECp.Lyc.Aur.bu.Hma1.
    mannose-binding
    lectins.
    [420] Maackia MALb, MAHb, Legume lectins. LECp.Maa.Amu.se.Hsi1
    amurensis. MAL, MAHs. (MAHs, MAH)
    LECp.Maa.Amu.se.Hsi2
    (MAHs, MAH)
    LECp.Maa.Amu.ba.Hsi1
    (MAHb)
    LECp.Maa.Amu.ba.Hsi1
    (MALb).
    [421] Machaerocereus MEA-I, MEA-II. ?. LECp.Mac.Eru.st.Hga1.
    eruca.
    [422] Machaerocereus Hevein domain LECp.Mac.Gum.xx.Xxxx.
    gummosus. lectin, chitin
    binding.
    [423] Maclura pomifera. MPA. beta-prism plant LECi.Mac.Pom.xx.Xxxx.
    lectin.
    [424] Macrobdella LL1-63. LECi.Mac.Dec.xx.Xxxx.
    decora.
    [425] Macrobrachium MrL. LECi.Mac.Ros.xx.Xxxx.
    rosenbergii.
    [426] Macrotyloma LECp.Mac.Axi.xx.Xxxx.
    axillare.
    [427] Malus officinalis. LECp.Mal.Off.xx.Xxxx.
    [428] Manduca sexta. Immulectin. C-lectin. LECi.Man.Sex.xx.Xxxx.
    [429] Mangifera indica. MIA. LECp.Man.Ind.xx.Xxxx.
    [430] Marah LECp.Mar.Mac.xx.Xxxx.
    macrocarpus.
    [431] Marasmius LECf.Mar.Ore.xx.Xxxx.
    oreades.
    [432] Medicago sativa. LECp.Med.Sat.xx.Xxxx.
    [433] Medicago LECp.Med.Tru.xx.Xxxx.
    truncatula.
    [434] Megabalanus rosa. LECi.Mag.Ros.xx.Xxxx.
    [435] Megapitaria LECi.Meg.Squ.xx.Xxxx.
    squalida.
    [436] Melanoleuca LECf.Mel.Mel.xx.Xxxx.
    melaleuca.
    [437] Melastiza chateri. LECf.Mel.Cha.xx.Xxxx.
    [438] Mesocricetus Pentraxin. LECz.Ggg.Sss.xx.Xxxx.
    auratus.
    [474] Orchidaceae. LECp.Orc.Sss.xx.Xxxx.
    [475] Omithodoros Dorin-M. LECi.Orn.Mou.xx.Xxxx.
    moubata.
    [476] Oryza sativa. OSA. Chitin binding LECp.Ory.Sat.see.Hch1.
    lectins.
    [477] Oscillatoria LECu.Osc.Aga.xx.Xxxx.
    agardhii.
    [478] Otala lactea. LECi.Ota.Lac.xx.Xxxx.
    [480] Pachydereus LECp.Pac.Pri.se.Hch1.
    pringleii.
    [481] Pacifastacus LECi.Pac.Len.xx.Xxxx.
    leniusculus.
    [482] Palmaria palmata. LECz.Pal.Pal.xx.Xxxx.
    [483] Paracentrotus LECi.Par.Liv.xx.Xxxx.
    lividus.
    [484] Parkia LECp.Par.Big.xx.Xxxx.
    biglandulosa.
    [485] Parkia discolor. LECz.Par.Dis.xx.Xxxx.
    [486] Parkia LECz.Par.Pla.xx.Xxxx.
    platycephala.
    [487] Parkia speciosa. LECp.Park.Spe.xx.Xxxx.
    [488] Paxillus LECz.Pax.Atr.xx.Xxxx.
    atrotomentosus.
    [489] Paxillus LECf.Pax.Pan.Sss.xx.Xxxx.
    panuoides.
    [490] Penaeus LECp.Pen.Cal.xx.Xxxx.
    californiensis.
    [492] Penaeus LECi.Pen.Sty.xx.Xxxx.
    stylirostris.
    [494] Penaeus vannamei. LECi.Pen.Van.xx.Xxxx.
    [495] Perca fluviatilis. LECa.Per.Flu.xx.Xxxx.
    [496] Peresea gratissima. LECz.Per.Gra.xx.Xxxx.
    [497] Persea americana. PAA. LECp.Per.Ame.xx.Xxxx.
    [498] Petromyzon LECz.Pet.Mar.xx.Xxxx.
    marinus.
    [499] Petrosecinum LECp.Pet.Hor.xx.Xxxx.
    hortense.
    [500] Peziza badia. LECp.Pez.Bad.xx.Xxxx.
    [501] Phage p22. Phage P22 LECb.Ggg.Sss.xx.Xxxx.
    TailspikeProteins
    (1TSP).
    [502] Phalera flavescens. PFA. LECi.Pha.Fla.xx.Xxxx.
    [503] Phallus impudicus. LECf.Pha.Imp.xx.Xxxx.
    [504] Phallusia LECi.Pha.Mam.xx.Xxxx.
    mamillata.
    [505] Phaseolus Legume lectins. LECp.Pha.Acu.se.Hcu1
    acutifolius. (erythroagglutinin)
    LECp.Pha.Acu.se.Hcu2
    (lymphoagglutinin).
    [506] Phaseolus aureus. LECp.Pha.Aur.xx.Xxxx.
    [507] Phaseolus PCA. Legume lectin. LECp.Pha.Coc.se.Hcu1
    coccineus. (PCA)
    LECp.Pha.Coc.se.Hcu2.
    [508] Phaseolus LECp.Pha.Coc.xx.Xxxx.
    coccineus.
    [509] Phaseolus PLA, LBA, LBL. Legume lectins. LECp.Pha.Lim.se.Hga1.
    limenesis.
    [510] Phaseolus lunatus. LECp.Pha.Lun.se.Xxxx.
    [511] Phaseolus PHA-E, PHA-L. Legume lectin. LECp.Pha.Vul.xx.Xxxx.
    vulgaris.
    [512] Phaseolus GN1L, GNpL, GNsL. LECp.Pha.Vul.xx.Xxxx.
    vulgaris.
    [513] Phaseolus Pinto III. LECa.Pha.Vul.xx.Xxxx.
    vulgaris.
    [514] Phaseolus LECp.Pha.Vul.xx.Xxxx.
    vulgaris.
    [515] Phaseolus LECp.Pha.Vul.xx.Xxxx.
    vulgaris.
    [516] Phaseolus LECp.Pha.Vul.xx.Xxxx.
    vulgaris.
    [517] Phaseolus LECp.Pha.Vul.xx.Xxxx.
    vulgaris.
    [518] Phaseolus LECp.Pha.Vul.xx.Xxxx.
    vulgaris.
    [519] Phaseolus LECp.Pha.Vul.xx.Xxxx.
    vulgaris.
    [520] Phlomis LECz.Phl.Fru.xx.Xxxx.
    fructicosa.
    [521] Pholiota aurivella. PAA. LECf.Ggg.Sss.xx.Xxxx.
    [522] Pholiota squarrosa. LECf.Pho.Squ.xx.Xxxx.
    [524] Phoradendron LECz.Pjo.Cal.xx.Xxxx.
    californicum.
    [525] Phragmites. LECz.Phr.sss.xx.Xxxx.
    [526] Phragmites LECp.Phr.Aus.xx.Xxxx.
    austalis.
    [527] Physalia physalis. Physalitoxin. LECi.Phy.Phy.xx.Xxxx.
    [528] Physalis angulata. PA-VII-A, PA-VII-B LECz.Phy.Ang.xx.Xxxx.
    and PA-VII-C.
    [529] Physarum LECu.Phy.Pol.xx.Xxxx.
    polycephalum.
    [530] Phytolacca PWM, Pa-1, Pa-2 LECp.Phy.Ame.ro.Hch1(Pa-1)
    americana. (PL-A) Pa-3, Pa-4 LECp.Phy.Ame.ro.Hch2(Pa-2)
    (PL-C), Pa-5. LECp.Phy.Ame.ro.Hch3(Pa-3)
    LECp.Phy.Ame.ro.Hch4(Pa-4)
    LECp.Phy.Ame.ro.Hch5(Pa-5)
    LECp.Phy.Ame.ro.Hch6(PL-B).
    [531] Pimenta LECp.Pim.Off.xx.Xxxx.
    officinalis.
    [532] Pisum sativum. PSA, PsA. Legume lectins. LECp.Pis.Sat.se.Hmg1
    (PSA, PsA)
    LECp.Pis.Sat.ro.Hmg1.
    [533] Plecoglossus PAL. LECa.Ple.Alt.xx.Xxxx.
    altivelis.
    [535] Pleurocybella LECf.Ggg.Sss.xx.Xxxx.
    porrigens.
    [536] Pleurotus LECf.Ple.Ost.xx.Xxxx.
    ostreatus.
    [537] Plumaria elegans. LECu.Plu.Ele.xx.Xxxx.
    [538] Polyandrocarpa C-lectin. LECi.Pol.Mis.xx.Xga1.
    misakiensis.
    [539] Polygonum LECp.Pol.Mul.xx.Xxxx.
    multiformum.
    [540] Polyomavirus. 1VPN. LECV.Pol.Vir.xx.Xxxx.
    [541] Polyporus LECf.Pol.Fom.xx.Xxxx.
    fomentarius.
    [542] Polyporus LECf.Pol.Squ.xx.Xxxx.
    squamosus.
    [543] Polysphondylium LECu.Pol.Pal.xx.Xxxx.
    pallidum.
    [544] Potamon LECi.Pot.Pot.xx.Xxxx.
    potamios.
    [545] Prunus Americana. LECp.Pru.Ame.xx.Xxxx.
    [546] Prunus avium. LECp.Pru.Avi.xx.Xxxx.
    [547] Psathyrostachys Hevein domain LECp.Psa.Jun.se.Hch1.
    juncea. lectin, chitin
    binding.
    [548] Pseudomonas LECb.Pse.Aer.xx.Xga1.
    aeruginosa.
    [549] Pseudomonas LECb.Pse.Apl.xx.Xxxx.
    aplysia.
    [550] Psophocarpus PTL-I (WBA-I), LECp.Pso.Tet.se.Hga1
    tetragonolobus. PTL-II (WBA-II), (PTL-I)
    WBTL, L-I, L-II. LECp.Pso.Tet.se.Hga2
    (PTL-II)
    LECp.Pso.Tet.ro.Hga1
    (WBTL)
    LECp.Pso.Tet.so.Hga2
    LECp.Pso.Tet.le.Hga1 (L-I)
    LECp.Pso.Tet.le.Hga2 (L-II).
    [551] Ptilota serrata. LECu.Pxx.Ser.xx.Xxxx.
    [552] Punica granatum. LECp.Pun.Gra.xx.Xxxx.
    [553] Rana catesbeiana. Lectins LECa.Ran.Cat.xx.Xxxx.
    Displaying RNase
    Activity
    (Leczymes).
    [554] Rana catesbeiana cSBL. Lectins LECa.Ran.Cat.xx.Xxxx.
    ovum lectin. Displaying RNase
    Activity
    (Leczymes).
    [555] Rana japonica. jSBL. Lectins LECa.Ran.Jap.xx.Xxxx.
    Displaying RNase
    Activity
    (Leczymes).
    [557] Rana LECa.Ran.Nig.xx.Xxxx.
    nigromaculata.
    [558] Raphanus sativus. LECp.Rap.Sat.xx.Xxxx.
    [559] Ratus norvegicus. Mannan Binding C-lectin or LECa.Rat.Nor.xx.Xxxx.
    Protein (MBP-A). Collectin.
    [560] Ratus ratus. Rat peritioneal LECa.Rat.Rat.xx.Xfu1
    macrophage lectin. LECa.Rat.Rat.xx.Xga1.
    [561] Ratus ratus. LECa.Rat.Rat.xx.Xxxx.
    [562] Ratus ratus. Galectin II. S-lectin or GLT2.Rat.Rat.xx.Xxxx.
    Galectin.
    [563] Ratus ratus. Galectin IV. Tandem Repeat GLTa.Rat.Rat.xx.Xxxx.
    S-lectin or
    Galectin.
    [564] Rheum LECp.Rhe.Rhas.xx.Xxxx.
    rhapontium.
    [565] Ribes rubrum. LECp.Rib.Rubs.xx.Xxxx.
    [566] Ricinus RCA-I, RCA-II, beta-trefoil lectin. LECp.Ric.Com.se.Cga1
    communis. Ricin. (Ricin D)
    LECp.Ric.Com.se.Cga2
    (Ricin E)
    LECp.Ric.Com.se.Cga2
    (RCA, RSL).
    [567] Robinia RPA-I, RCA-III. LECp.Rob.Pse.se.Hcu1
    pseudoacacia. (RPsA-I)
    LECp.Rob.Pse.se.Hcu2
    (RPsA-II)
    LECp.Rob.Pse.se.Hcu1
    (RPbA-I)
    LECp.Rob.Pse.se.Hcu2
    (RPbA-II).
    [568] Rubus fructicosus. RFA. ?. LECp.Rub.Fru.tc.Xga1.
    [569] Rubus idaeus. LECp.Rub.Ida.xx.Xxxx.
    [570] Rutilus rutilus. LECv.Rut.Rut.xx.Xxxx.
    [571] Salmo gairdneri. LECa.Sal.Gai.xx.Xxxx.
    [572] Salmo salar v. LECa.Sal.Sal.xx.Xma1.
    Atlantica.
    [573] Salmo salar v. LECa.Sal.Sal.xx.Xxxx.
    Chinook.
    [574] Salmo trutta. LECa.Sal.Tru.xx.Xxxx.
    [618] Tetragonolobus LECp.Tet.Pur.xx.Xxxx.
    pupurea.
    [619] Thermopsis. LECz.The.sss.xx.Xxxx.
    [621] Toxopneustes C-lectin. LECi.Xxx.Xxx.xx.Xxxx.
    pileolu.
    [622] Trichoderma. LECf.Tri.Sss.xx.Xxxx.
    [623] Tricholoma LECf.Tri.Mon.xx.Xxxx.
    mongolicum.
    [624] Tricholomataceae LECf.Tri.Sss.xx.Xxxx.
    93-138.
    [625] Tricholomataceae LECz.Tri.Sss.xx.Xxxx.
    93-34.
    [626] Trichosanthes TJA-II, TJA-I, TK-I, LECp.Tri.Jap.xx.Xxxx.
    japonica. TK-II.
    [627] Trifolium repens. LECp.Tri.Rep.xx.Xxxx.
    [628] Triticum WGA. Hevein domain LECp.Tri.Aes.se.Hch1.
    aestivium. lectin, chitin
    binding lectin.
    [629] Tulipa gesneriana. TGA. LECp.Tul.Ges.xx.Xxxx.
    [630] Udotea petiolata. LECp.Udo.Pet.xx.Xxxx.
    [631] Ulex europaeus. UEA-I, UEA-II, Legume lectin. LECp.Ule.Eur.xx.Xxxx.
    UEA-III.
    [632] Ulva lactuca. LECu.Ulv.Lac.xx.Xxxx.
    [633] Ulva laetevirens. LECu.Ulv.Lae.xx.Xxxx.
    [635] Ulva rigida. LECz.Ulv.Rig.xx.Xxxx.
    [637] Urtica dioica. UDA. Chitin-binding LECp.Urt.Dio.rh.Hch1.
    lectins.
    [638] Vaejovis LECi.Vae.Con.xx.Xxxx.
    confuscius.
    [639] Vatairea VML. LECp.Vat.Mac.xx.Xxxx.
    macrocarpa.
    [640] Vibrio LECb.Vib.Alg.xx.Xch1.
    alginolyticus.
    [641] Vibrio chlolera. VPCV; Chitovibrin. LECb.Vib.Cho.xx.Xxxx.
    [642] Vicia cracca. LECp.Vic.Cra.xx.Xxxx.
    [643] Vicia ervilia. LECp.Vic.Erv.xx.Xxxx.
    [644] Vicia faba. VFA, Favin. Legume lectin. LECp.Vic.Fab.xx.Xxxx.
    [645] Vicia graminea. VGA. LECp.Vic.Gra.xx.Xxxx.
    [646] Vicia hyrcanica. LECp.Vic.Hyr.xx.Xxxx.
    [647] Vicia sativa. LECp.Vic.Sat.xx.Xxxx.
    [648] Vicia unijuga. VUA. LECp.Vic.Unj.xx.Xxxx.
    [649] Vicia villosa. VVA-A4, VVL-A4. Legume lectin. LECp.Vic.Vil.xx.Xxxx.
    [650] Vigna radiata. MBL-I, MBL-II. LECp.Vig.Rad.xx.Xxxx.
    [651] Vigna unguiculata. LECp.Vig.Ung.xx.Xxxx.
    [652] Viscum album. ML-I, ML-II, ML-III, Beta-trefoil lectin LECp.Vis.Alb.pl.Cga1
    Viscumin, (ML-I). (ML-I, viscumin)
    VisAlbCBA. LECp.Vis.Alb.pl.Cga2
    (ML-II, viscumin)
    LECp.Vis.Alb.pl.Cga3
    (ML-III, VAA-II)
    LECp.Vis.Alb.pl.Hch1
    (VisAlbCBA).
    [653] Vitis vinifera. LECp.Vit.Vin.xx.Xxxx.
    [654] Volvariella VVL. LECf.Vol.Vol.xx.Xxxx.
    volvacea.
    [655] Wistaria WFA. LECp.Wis.Flo.xx.Xxxx.
    floribunda.
    [656] Wistaria LECp.Wis.Flo.xx.Xxxx.
    floribunda.
    [657] Wistaria sinensis. LECp.Wis.Sin.xx.Xxxx.
    [658] Wistaris LECz.Wis.Bra.xx.Xxxx.
    brachbotrys.
    [659] Xanthosoma LECp.Xan.Sag.xx.Xxxx.
    sagittifolium.
    [660] Xenopus laevis LECa.Xen.Lae.xx.Xga1.
    ovum.
    [661] Xeromus LECz.Xer.Chr.xx.Xxxx.
    chrysenteron.
    [662] Xylaria LECf.Xyl.Pol.xx.Xxxx.
    polymorpha.
    [663] Zea mays. ZMA-I, ZMA-II, LECp.Zea.May.xx.Xxxx.
    ZMEA.
    [664] Cannabis sativa. CSA. LECp.CanSat.se.Glu.
    [665] Smilax glabra. Sarparilla. LECp.SmiGla.rh.xxx.
    [666] Trichosanthes Snake gourd.
    anguina.
  • Lectin codes take the following form:
    LLLx.Ggg.Sss.ti.TspN

    An explanation of each index variable follows.
  • LLL refers to the general category of agglutinin. At this point six general categories are recognized: lectins (LEC), integrins (INT), cadherins (CDH), annexins (ANN), selectins (SEL) and galectins (GLT). The x value refers to the taxonomic groups of the agglutinin, Table 1 summarizes these categories:
    Category Taxonomic group
    LECa, GLTa Lectin or galectin from
    higher animal, typically
    vertebrates.
    LECh, GLTh Lectin or galectin from
    humans
    LECi, GLTi Lectin or galectin from
    invertebrates
    LECp. Plant lectins
    LECf. Lectin from fungi
    LECu. Lectin from unicellular
    organisms
    LECb. Lectin from Bacteria
    LECv. Viral lectins
    • Ggg stands for the three first letters of the plant genus name (in Latin).
    • Sss stands for the three first letters of the plant species name (in Latin).
  • ti refers to the tissue from which the lectin has been isolated. Table 2 summarizes the indices used for the various tissues:
    Tissue, Taxonomic
    cell or organ grouping Index
    Bark Plant Ba
    Bulb Plant Bu
    Cell membrane Bacteria, Unicellular Cm
    Epidermis Human, vertebrates Ep
    Fruit Plant Fr
    Hemolymph Invertebrates He
    Latex Plant La
    Leaf Plant Le
    Nodule Plant No
    Organ or cell type Human, vertebrates, Oc
    Invertebrates
    Phloem sap Plant Ps
    Rhizome Plant Rh
    Root Plant Ro
    Seed Plant Se
    Serum or plasma Human, vertebrates, Sr
    Invertebrates
    Spores or fruiting bodies Fungi Sp
    Stem Plant St
    Tentacles Invertebrates Te
    Tuber Plant Tu
    Whole body homogenate Invertebrates Wb
    Venom Invertebrates Ve
    Undefined Human, vertebrates, Un
    Invertebrates, Bacteria,
    Unicellular, Virus, Fungal
    • T refers to the lectin subtype. Hololectins, merolectins, chimerolectins and superlectins are indicated by the letters H, M, C and S, respectively.
  • sp refers to the specificity group. Each group is indicated by the index given in Table 3:
    Specificity Index of group
    Mannose-binding lectins ma
    Mannose/maltose-binding mm
    lectins
    Mannose/glucose-binding mg
    lectins
    GlcNAc/(GlcNAc)-binding ch
    lectins
    Gal/GalNAc-binding lectins ga
    Fucose-binding lectins fu
    Sialic acid-binding lectins si
    Lectins with a complex but co
    known specificity
    Lectins with a complex and cu
    unknown specificity
    Lectins with a dual du
    specificity
    Lectins with an undetermined nd
    specificity
  • Lipids
  • A multifunctional molecule of the invention can also be a molecule that comprises a first part which comprises a lipid and a second part which comprises an amino acid sequence which can bind to a cell surface molecule, e.g. a cell surface molecule of an APC. The attachment of a lipid, e.g. a long-chain fatty acid, to a molecule, e.g. a polypeptide, can permit the complex to become stably associated with the plasma membrane when the complex is admixed with a cell (Nagarajan et al, 1995, J Immunol Methods 184:241-51; McHugh et al, 1995, PNAS 92:8059-63; van den Berg et al, 1995, J Cell Biol, 131:669-77). This is believed to occur through intercalation of the lipid into the membrane. A convenient method of producing a lipid-associated polypeptide comprises expressing, in a suitable host cell, a nucleic acid encoding, in part, a signal sequence directing the post-translational addition of a GPI moiety. Using recombinant DNA technology, a naturally non-GPI linked protein can be expressed as a GPI-linked protein by constructing a nucleic acid that encodes the protein linked to a heterologous GPI signal sequence. Nucleotide sequences encoding GPI signal sequences useful for this purpose include, for example, those comprised by decay accelerating factor (e.g., sequences encoding amino acid sequence “22” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32; sequences encoding signal sequences disclosed in Caras et al, U.S. Pat. No. 5,109,113); brevican (e.g., nt 1982-2047 of Genbank accession number X86406), mesothelin (e.g., nt 1858-1983 of Genbank U40434), coccidioides immitis antigen 2 (e.g., sequences encoding amino acids 172-194 of NCBI Entrez protein database accession #1256444, Zhu et al, 1996, Gene 181:121-5), acetylcholinesterase (e.g., sequences encoding the peptide “HC” as described in Duval et al, 1992, EMBO J. 11:3255-61; (e.g., sequences encoding amino acid sequence “19” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32)), human folate receptors alpha and beta (e.g., sequences encoding amino acids 230-257 of NCBI Entrez protein database accession #182416 or amino acids 228-255 of NCBI Entrez protein database accession #1655592, Yan and Ratnam, 1995, Biochemistry 34:14594-600), 5′ nucleotidase (e.g., sequences encoding amino acids 547-570 or 547-574 of NCBI Entrez protein database accession #404502, Furukawa et al, 1994, Biochim Biophys Acta 1190:273-8; (e.g., sequences encoding amino acid sequences “5” or “6” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32)), CD59 (e.g. encoded by nt 393-473 of Genbank U48255; sequences encoding amino acid sequence “20” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32; sequences encoding amino acids 74-101 of FIG. 2 of Powell et al, 1997, J Immunol 158:1692-1702), T-cadherin (e.g., sequences encoding the 76 C-terminal amino acids of chick T cadherin as described by Koller and Ranscht, 1996, J Biol Chem 271:30061-7), aminopeptidase P (e.g., sequences encoding amino acids 649-673 of NCBI Entrez protein database accession #1517942, Hyde et al, 1996, Biochem J 319:197-201), carboxypeptidase M, CD16B, Thy 1, carbonic anhydrase IV (e.g., sequences encoding amino acids 284-312 of NCBI Entrez protein database accession #179791, Okuyama et al, 1995, Arch Biochem Biophys 320:315-22), placental alkaline phosphatase (e.g., sequences encoding amino acids 498-529 of NCBI Entrez protein database accession #178464, Oda et al, 1994, Biochem J 301:577-83), neuronal glycoprotein F3, carcinoembryonic antigen (e.g., sequences encoding amino acid sequence “28” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), MRC-OX45 (e.g., sequences encoding amino acid sequence “2” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), RT 6.2 (e.g., sequences encoding amino acid sequence “3” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), D. discoideum prespore-specific antigen (e.g., sequences encoding amino acid sequence “4” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), microsomal dipeptidase (e.g., sequences encoding amino acid sequence “8” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), CAMPATH-1 (e.g., sequences encoding amino acid sequence “9” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei PARP (e.g., sequences encoding amino acid sequence “10” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG Mit 118a (e.g., sequences encoding amino acid sequence “11” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG Mit 117a (e.g., sequences encoding amino acid sequence “12” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG MITat 1.1000 BC (e.g., sequences encoding amino acid sequence “13” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG MITat 1.5b (e.g., sequences encoding amino acid sequence “14” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG ILTat 1.1 (e.g., sequences encoding amino acid sequence “15” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG TxTat 1 (e.g., sequences encoding amino acid sequence “16” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. brucei VSG Mit 221 (e.g., sequences encoding amino acid sequence “17” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), prion proteins (e.g., sequences encoding amino acid sequence “18” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), urokinase receptor (e.g., sequences encoding amino acid sequence “21” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), T. congolense VSG YNat 1.1 (e.g., sequences encoding amino acid sequence “23” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), S. cerevesiae GAS-1 (e.g., sequences encoding amino acid sequence “24” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), Thy-1 (e.g., sequences encoding amino acid sequences “25” or “26” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), L. major PSP (e.g., sequences encoding amino acid sequence “29” in Table 1 of Bucht and Hjalmarsson, 1996, Biochim Biophys Acta 1292:223-32), D. discoideum contact site A glycoprotein (e.g., sequences encoding the 25 C-terminal amino acids as described in Barth et al, 1996, Biochem J 317:533-40) CD24, and synthetic sequences (e.g. as described by Coyne et al, 1993, J Biol Chem 268:6689-93).
  • GPI-linked polypeptides can be extracted from cells using the following method. 5×106 cells are spun down and frozen at −80° C. The pellet is thawed in 14 ml of 0.15M NaCl/10 mM Tris 7.4/0.1 mM primaquine/2% Trito X-114 with stirring at 0° C. for 1 h, then centrifuged at 8800 g at 0° C. for 10 min. The supernatant is maintained at −20° C. overnight, thawed at room temperature, and then placed at 32° C. for 12 min. It is then centrifuged at 3000 g for 3 min at 32° C. The top layer is decanted and 11 ml of cold Buffer A (0.15M NaCl/10 mM Tris 7.4/0.1 mM primaquine/0.06% Triton X-114) is added to the bottom layer. This is incubated on ice for 10 min. The 12 min 32° C. incubation 32° C. 30002 centrifugation, decanting of top layer, and addition of 11 ml cold Buffer A to bottom layer are repeated. The solution is centrifuged at 18000 g for 10 min at 0° C. The 12 min 32° C. incubation, 32° C. 3000 g centrifugation, and decanting of top layer are repeated. 3 vol of cold acetone are added to the final bottom phase. The solution is centrifuged at 12, 000 RPM for 30 min, the supernatant removed, and the protein pellet containing the GPI fraction dried under vacuum. Specific proteins can be purified by methods well-known to those skilled in the art, e.g. immunoaffinity purification.
  • Another method of producing a lipid-linked polypeptide is to chemically link the polypeptide to a fatty acid such as palmitate. 1.5 mg/ml of the polypeptide is suspended in PBS, pH 7.8, containing 0.3% deeoxycholic acid, 0.1% sodium bicarbonate, and 0.1% sodium azide. The optimal final pH of the solution is 7.6-8.0. The mixture is warmed to 37° C. and the N-hydroxysuccinimide ester of palmitic acid (Research Organics, Cleveland, Ohio) is added to a final concentration of 0.1 mg/ml. The solution is incubated overnight at room temperature. The polypeptide is purified by passage through a 16×250 mm Sephadex G-75 chromatography column equilibrated with 0.15% deoxycholic acid in PBS, pH 7.6.
  • Crosslinking Moieties Useful According to the Invention
  • Another convenient method of linking a ligand to an antigen bearing target is to use a crosslinking agent. A “crosslinking agent” is a chemical entity that can react with functional groups on at least two other molecules, e.g. two polypeptides or a polypeptide and a lipid, such that upon reaction with the crosslinking agent the two molecules become covalently linked. Thus, a ligand for CD40 can be crosslinked to a molecule on the surface of a cell.
  • A wide variety of crosslinking agents, both bifunctional and polyfunctional, are known in the art and are commercially available, e.g. from Sigma (St. Louis, Mo.). These include, for example, S-acetylmercaptosuccinic anhydride, 5-acetylthioglycolic acid N-hydroxysuccinimide ester, S-acetylthiopropionic acid N-hydroxysuccinimide ester, adipic acid dihydrazide, 4-azidobenzoic acid N-hydroxysuccinimide ester, N-(5-azido-2-nitrobenzyloxy)succinimide, 6-(4-azido-2-nitrophenylamino)hexanoic acid N-hydroxysuccinimide ester, p-azidophenacyl bromide, N-(4-azidophenylthio)phthalimide, 4-azidosalicylic acid N-hydroxysuccinimide ester, bromoacetic acid N-hydroxysuccinimide ester, 1,4-butanediol diglycidyl ether, carbonyl-bis(L-methionine p-nitrophenyl ester), 2-diazo-3,3,3-trifluoropropionic acid p-nitrophenyl ester, diethyl malonimidate, 1,5-difluoro-2,4-dinitrobenzene, 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid, dimethyl adipimidate, dimethyl 3,3′-dithiobispropionimidate, dimethyl pimelimidate, dimethyl suberimidate, 4,4′-dithiobisphenyl azide, dithiobis(propionic acid N-hydroxysuccinimide ester), ethylene glycol bis-(succinic acid N-hydroxysuccinimide ester), 4-fluoro-3-nitrophenyl azide, bis-(4-fluoro-3-nitrophenyl) sulfone, p-formylbenzoic acid N-hydroxysuccinimide ester, glutaraldehyde, 2-iminothiolane, 6-(iodoacetamido)caproic acid N-hydroxysuccinimide ester, iodoacetic acid N-hydroxysuccinimide ester, 3-malemidoacetic acid N-hydroxysuccinimide ester, 3-malemidobenzoic acid N-hydroxysuccinimide ester, 4-(N-malemido)benzophenone, gamma-malemidobutyric acid N-hydroxysuccinimide ester, epsilon-malemidocaproic acid N-hydroxysuccinimide ester, 4-(N-malemidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester, 4-(N-malemidomethyl)cyclohexanecarboxylic acid 3-sulfo-N-hydroxysuccinimide ester, beta-malemidopropionic acid N-hydroxysuccinimide ester, N,N′-bis(3-malemidopropionyl)-2-hydroxy-1,3-propanediamine, 1,4-phenylene diisothiocyanate, N,N′-o-phenylene dimalemide, N,N′-p-phenylene dimalemide, polyoxyethylene bis(glycidyl ether), bis(polyoxyethylene bis(glycidyl ether)), polyoxyethylene bis(imidazolylcarbonyl), bis(polyoxyethylene bis(imidazolylcarbonyl)), polyoxyethylene bis(p-nitrophenyl carbonate), 3-(2-pyridyldithio)propionic acid N-hydroxysuccinimide ester, suberic acid bis(N-hydroxysuccinimide) ester, succinic acid malemidoethyl N-hydroxysuccinimide ester, 1, 5 bis(succinimidooxycarbonyloxy)-pentane, and bis(N-succinimidyl) carbonate.
  • Ligands of a Cell Surface Protein
  • The multifunctional molecules of the present invention comprise one part which is a lectin and is capable of binding to at least one carbohydrate molecule on an antigen bearing target, and a second part comprising a ligand for a cell surface protein of an antigen presenting cell. The ligand can be any ligand which binds to one or more of the cell surface molecules indicated by GenBank Accession number in Appendix I or II. More preferably, however, the ligand includes, but is not limited to an opsonin, a cytokine, a heat shock protein, an adhesion molecule. a defensin, or a counterreceptor for a T cell costimulatory molecule; or a portion of any of these molecules, e.g., about (or at least about) 5, 8, 10, 12, 15, 20, 25, 35, 40, 50, 60, 70, 80, 100, or 120 contiguous amino acid residues, up to the full length of such a molecule.
  • Cytokines Useful According to the Invention
  • The term “cytokine” as defined hereinabove refers to a polypeptide molecule that is naturally secreted by mammalian cells and that binds to a cell surface receptor on a leukocyte. The term “cytokine” also refers herein to a polypeptide molecule that is a ligand for a receptor for a naturally occurring cytokine. Unlike an opsonin, a cytokine does not naturally contemporaneously bind an antigen and a cell-surface receptor.
  • Leukocytes which bear receptors for cytokines include, for example, monocytes, macrophages, dendritic cells, neutrophils, eosinophils, basophils, platelets, lymphocytes, T lymphocytes, B lymphocytes, NK cells, myeloma cells, lymphoma cells, and leukemic cells.
  • Without being bound by any one mechanism, it is believed that cell-surface associated cytokines provide an advantage over freely diffusible cytokines by allowing stable juxtaposition of the cytokine to the cell, thus increasing the concentration of cytokine in the vicinity of the cell.
  • Preferred cytokines are non-rodent cytokines, e.g primate, e.g. human cytokines.
  • Some cytokines can be regarded as belonging to one or more families of cytokines based on structural and/or functional properties. One such family consists of the interleukins. Interleukins are structurally diverse, but share the property of both being expressed by and acting on leukocytes. Examples of interleukins include IL-1 (e.g. polypeptides encoded by Genbank Accession No. M15330, M28983, E04743, M15131) IL-2 (e.g. polypeptides encoded by Genbank Accession No. E01108, K02797), IL-3 (e.g. polypeptides encoded by Genbank Accession No. A02046, M14743), IL-4 (e.g. polypeptides encoded by M13982, M25892), IL-5 (e.g. polypeptides encoded by X06270, J03478), IL-6 (e.g. polypeptides encoded by E02772, M20572), IL-7 (e.g. polypeptides encoded by J04156, M29054-29057), IL-8 (e.g. polypeptides encoded by M28130), IL-9 (e.g. sequences disclosed in Kelleher et al, Blood. 1991; 77: 1436-1441, Immunogenetics 1990;31(4):265-270), IL-10 (e.g. polypeptides encoded by M84340, U16720), IL-11 (e.g. sequences disclosed in Paul et al, Proc Natl Acad Sci USA. 1990; 87: 7512-7516, Morris et al, Exp Hematol. 1996; 24: 1369-1376), IL-12 (e.g. polypeptides encoded by Genbank Accession No. M86671, S82412; Genbank protein P29459, P29460), IL-13 (e.g. polypeptides encoded by U31120, L13028), 1L-14 (e.g. sequences disclosed in Ambrus et al, Proceedings of the National Academy of Science (USA) 1993; 90: 6330-4), IL-15 (e.g. polypeptides encoded by AF031167, U22339), 1L-16 (e.g. polypeptides encoded by AF006001, M90391), IL-17 (e.g. polypeptides encoded by U32659, U43088), IL-18 (e.g. polypeptides encoded by D49949, D49950), IL-19 (e.g. polypeptides encoded by AY040367), IL-20 (e.g. polypeptides encoded by NM02130, NM018724), IL-21 (e.g. polypeptides encoded by AF254069, AF254070), IL-22 (e.g. polypeptides encoded by AF279437), IL-23 (e.g. polypeptides encoded by AF301619, AF301620, AY055379 [p19 alpha chain combines with IL-12 p40 chain to form IL-23]), IL-24 (e.g. polypeptides encoded by AF276916, NM053095), IL-25 (e.g. polypeptides encoded by NM080837), TNF-alpha (e.g. polypeptides encoded by M16441, Y00467), and GM-CSF (e.g. polypeptides encoded by X03019, M11220) and their homologues among species. Nucleotide sequences encoding homologues will hybridize to each other under moderate- to high-stringency conditions.
  • Another family consists of the hematopoietins. Members of this family comprise helical regions, known as helices A, B, C, and D. Helices A and B and helices C and D run roughly parallel to each other, respectively. Examples of hematopoietins include IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-11, IL-12, IL-13, IL-15, GM-CSF, G-CSF (e.g. polypeptides encoded by Genbank Accession No. E01219, M13926), oncostatin M (e.g. polypeptides encoded by Genbank Accession No. D31942, sequences disclosed in Malik et al, Mol Cell Biol 1989, 9:2847-2853), LIF (e.g. polypeptides encoded by Genbank Accession No. X13967, X06381), CNTF (e.g. polypeptides encoded by Genbank Accession No. U05342, X60542), and their homologues among species. Nucleotide sequences encoding homologues will hybridize to each other under moderate- to high-stringency conditions.
  • Human IL2 is a protein of 133 amino acids (15.4 kDa) with a slightly basic pI. Murine and human IL2 display a homology of approximately 65%. IL2 is synthesized as a precursor protein of 153 amino acids with the first 20 amino-terminal amino acids functioning as a hydrophobic secretory signal sequence. The protein contains a single disulfide bond (positions Cys58/105) essential for biological activity.
  • IL2 is O-glycosylated at threonine at position 3. Variants with different molecular masses and charges are due to variable glycosylation. Non-glycosylated IL2 is also biologically active. Glycosylation appears to promote elimination of the factor by hepatocytes.
  • A dimeric form of human IL2, produced by the action of a transglutaminase isolated from regenerating fish optic nerves, has been shown to be a cytotoxic factor for rat brain oligodendrocytes in culture.
  • The human IL2 gene contains four exons. The IL2 gene maps to human chromosome 4q26-28 (murine chromosome 3). The homology of murine and human IL2 is 72% at the nucleotide level in the coding region.
  • The biological activities of IL2 are mediated by a membrane receptor that is expressed almost exclusively on activated, but not on resting, T-cells at densities of 4-12×13 receptors/cell. Activated B-cells and resting mononuclear leukocytes rarely express this receptor. The expression of the IL2 receptor is modulated by IL5 and IL6. Three different types of IL2 receptors are distinguished that are expressed differentially and independently. The high affinity IL2 receptor (Kdis ˜10 pM) constitutes approximately 10% of all IL2 receptors expressed by a cells. This receptor is a membrane receptor complex consisting of the two subunits IL2R-alpha (TAC antigen=T-cell activation antigen; p55) and IL2R-beta (p75; CD122) as the ligand binding domains and a gamma chain as a signaling component. p75 is expressed constitutively on resting T-lymphocytes, NK-cells, and a number of other cell types while the expression of p55 is usually observed only after cell activation. p55 is, however, synthesized constitutively by a number of tumor cells and by HTLV-1-infected cells.
  • IL2 receptor expression of monocytes is induced by IFN-gamma, so that these cells become tumor-cytotoxic. In T-cells the expression of p75 can be reduced by IL3. An intermediate affinity IL2 receptor (Kdis=100 pM) consists of the p75 subunit and a gamma chain (see below) while a low affinity receptor (Kdis=10 nM) is formed by p55 alone.
  • p55 (e.g. polypeptides encoded by Genbank Accession No. X01057) has a length of 251 amino acids with an extracellular domain of 219 amino acids an a very short cytoplasmic domain of 13 amino acids. The p55 gene maps to human chromosome 10p14-p15.
  • p75 (e.g. polypeptides encoded by Genbank Accession No. M26062, M28052) has a length of 525 amino acids with an extracellular domain of 214 amino acids and a cytoplasmic domain of 286 amino acids. The p75 gene contains 10 exons and has a length of approximately 24 kb. It maps to human chromosome 22q11.2-q12 and to murine chromosome 15 (band E).
  • A third 64 kDa subunit of the IL2 receptor, designated gamma, has been described (e.g. polypeptides encoded by Genbank Accession No. D13821, D11086). Murine and human gamma subunits of the receptor have approximately 70% sequence identity at the nucleotide and amino acid levels. This subunit is required for the generation of high and intermediate affinity IL2 receptors but does not bind IL2 by itself. These two receptor types consist of an alpha-beta-gamma heterotrimer and a beta-gamma heterodimer, respectively. The gene encoding the gamma subunit of the IL2 receptor maps to human chromosome Xq13, spans approximately 4.2 kb and contains eight exons. The gamma subunit of the IL2 receptor has been shown recently to be a component of the receptors for IL4 and IL7. It is also believed to be a component of the IL13 receptor.
  • The amino acids at positions 267-317 lying directly adjacent to the transmembrane region of p75 are involved in IL2-mediated signal transduction. In addition the IL2 receptor is associated with a number of other proteins (p22, p40, p100) which are thought to be involved in mediating conformational changes in the receptor chains, receptor-mediated endocytosis, and further signal transduction processes. One of the identified proteins is the 95 kDa cell adhesion molecule ICAM-1 which probably focuses IL2 receptors at regions of cell-to-cell contacts and thus may mediate paracrine activities, for example, during IL2-mediated stimulation of T-cells. Another protein associated with p75 is a tyrosine-specific protein kinase called lck. The observation that proliferation of cells induced by IL2 is inhibited by specific inhibitors of protein tyrosine kinases in an lck negative cell line suggests that other kinases may also be associated with IL2 receptors. Two such kinases, called fyn and lyn, have been identified. In addition, IL2 receptor signaling may also be mediated by vav.
  • Activated lymphocytes continuously secrete a 42 kDa fragment of the TAC antigen. This fragment circulates in the serum and plasma and functions as a soluble IL2 receptor (sIL2R). The concentrations of this soluble receptor vary markedly in different pathological situations, for example, infections, autoimmune diseases, leukemias, or after organ transplantation. Levels may increase up to 100-fold. The levels of sIL2R appear to correlate with the severity of HIV-induces diseases and may be of diagnostic value also in other settings.
  • Mouse and human IL2 both cause proliferation of T-cells of the homologous species at high efficiency. Human IL2 also stimulates proliferation of mouse T-cells at similar concentrations, whereas mouse IL2 stimulates human T-cells at a lower (sixfold to 170-fold) efficiency.
  • IL2 is a growth factor for all subpopulations of T-lymphocytes. It is an antigen-unspecific proliferation factor for T-cells that induces cell cycle progression in resting cells and thus allows clonal expansion of activated T-lymphocytes. This effect is modulated by hormones such as prolactin.
  • IL2 also promotes the proliferation of activated B-cells also this requires the presence of additional factors, for example, IL4.
  • Due to its effects on T-cells and B-cells IL2 is a central regulator of immune responses. It also plays a role in anti-inflammatory reactions, in hematopoiesis and in tumor surveillance. IL2 stimulates the synthesis of IFN-gamma in peripheral leukocytes and also induces the secretion of IL1, TNF-alpha and TNF-beta.
  • It is believed that he induction of the secretion of tumoricidal cytokines apart from the activity in the expansion of LAK cells (lymphokine-activated killer cells) are probably the main factors responsible for the antitumor activity of IL2.
  • IL2 can be assayed in bioassays employing cell lines that respond to the factor (e.g., ATH8, CT6, CTLL-2, FDCPmix, HT-2, NKC3, TALL-103). Specific ELISA assays for IL2 and enzyme immunoassays for the soluble receptor are also available. The soluble receptor can be detected also by employing biotinylated IL2 and flow-through cytometry or ELISA assays.
  • IL2 displays significant anti-tumor activity for a variety of tumor cell types since it supports the proliferation and clonal expansion of T-cells that specifically attack certain tumors. IL2 is increasingly used to treat patients with cancers refractory to conventional treatment. Combination therapy with systemically administered IL2 has resulted in long-term remissions in 30% of patients with metastatic renal cell carcinoma, for which there is no standard treatment. Objective and long-lived clinical responses have been documented also in a proportion of patients with melanoma or acute myeloid leukemia.
  • High dose systemic IL2 therapy is also associated with a great number of unwanted toxic side-effects. IL2 has additional effects on other components of the cellular immune system, including B-cells and macrophages, and induces the secretion of other soluble mediators, including TNF-alpha, TNF-beta, and IFN-gamma. These effects may contribute to the antitumor activity of IL2 as well as to its dose-related toxicity.
  • The transduction of murine tumor cells with a functional IL2 gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts. Altered tumor cells expressing IL2 also increase systemic immunity.
  • Human IL4 is a protein of 129 amino acids (20 kDa) that is synthesized as a precursor containing a hydrophobic secretory signal sequence of 24 amino acids. IL4 is glycosylated at two arginine residues (positions 38 and 105) and contains six cysteine residues involved in disulfide bond formation. The disulfide bonds are essential for biological activity. Some glycosylation variants of IL4 have been described that differ in their biological activities. A comparison of murine and human IL4 shows that both proteins only diverge at positions 91-128.
  • An IL4 variant, Y124D, in which Tyr124 of the recombinant human protein is substituted by an aspartic acid residue, binds with high affinity to the IL4 receptor (Kd=310 pM). This variant is a powerful antagonist for the IL4 receptor system. It retains no detectable proliferative activity for T-cells and competitively inhibits IL4-dependent T-cell proliferation (K(i)=620 pM). The existence of this mutant demonstrates that high affinity binding and signal generation can be uncoupled efficiently in a ligand. Y124D also acts as a powerful antagonist for the IL13 receptor.
  • The human IL4 gene contains four exons and has a length of approximately 10 kb. It maps to chromosome 5q23-31. The murine gene maps to chromosome 11. The IL4 gene is in close proximity to other genes encoding hematopoietic growth factors (e.g., GM-CSF, M-CSF, IL3, IL5). The distance between the IL4 and the IL5 gene is approximately 90-240 kb.
  • At the nucleotide level the human and the murine IL4 gene display approximately 70% homology. The 5′ region of the IL4 contains several sequence elements, designated CLE (conserved lymphokine element), that are binding sites for transcription factors controlling the expression of this and other genes. A sequence motif, called P sequence (CGAAAATTTCC; SEQ ID NO: 1) in the 5′ region of the human IL4 gene (positions −79-−69) is the binding site for a nuclear factor, called NF(P), mediating the response to T-cell activation signals.
  • The biological activities of IL4 are mediated by a specific receptor (Kdis=20-100 pM) which is expressed at densities of 100-5000 copies/cell (e.g. polypeptides encoded by Genbank Accession No. M29854, X52425). The extracellular domain of the IL4 receptor is related to the receptors for erythropoietin (Epo), IL6, and the beta chain of the IL2 receptor. It has been given the name CD124.
  • The cDNA for the murine IL4 receptor encodes a transmembrane protein of 810 amino acids (including a secretory signal sequence). This receptor has a large intracellular domain of 553 amino acids. The human receptor has an extracellular domain of 207 amino acids, a transmembrane domain of 24 residues, and a large intracellular domain of 569 amino acids.
  • The IL4 receptor has been shown recently to contain the gamma subunit of the IL2 receptor as a signaling component. This gamma subunit is also associated with the receptors for IL4 and IL7 and probably also of IL13. Two forms of the receptor have been described, one of which is secreted. The secreted receptor only contains the extracellular IL4 binding domain and is capable of blocking IL4 activities. An IL4 binding protein (IL4-BP) that binds IL4 with the same affinity as the IL4 receptor has been shown also to be a soluble IL4 receptor variant. These soluble receptors probably function as physiological regulators of cytokine activities by inhibiting receptor binding or act as transport proteins. Soluble receptors or binding proteins have been described also for IL1 (IL1 receptor antagonist), IL2, IL6, IL7, TNF-alpha, IGF, and IFN-gamma.
  • The biological activities of IL4 are species-specific; mouse IL4 is inactive on human cells and human IL4 is inactive on murine cells. IL4 promotes the proliferation and differentiation of activated B-cells, the expression of class II MHC antigens, and of low-affinity IgE receptors in resting B-cells. IL4 enhances expression of class II MHC antigens on B-cells. It can promote their capacity to respond to other B-cell stimuli and to present antigens for T-cells. This may be one way to promote the clonal expansion of specific B-cells and the immune system may thus be able to respond to very low concentrations of antigens. The production of IL4 by non-B non-T-cells is stimulated if these cells interact with other cells via their Fc receptors for IgE or IgG. This effect can be enhanced by IL3. IL2 and PAF (platelet activating factor) induce the synthesis of IL4 while TGF-beta inhibits it.
  • IL3 antagonizes the IL2-induced effects in B-cells and causes a slow decrease of the expression of IL2 receptors, thus inhibiting the proliferation of human B-cells stimulated by IL2. In activated B-cells IL4 stimulates the synthesis of IgG1 and IgE and inhibits the synthesis of IgM, IgG3, IgG2a and IgG2b. This isotype switching induced by IL4 in B-cells is antagonized by IFN-gamma. The growth of multiple myelomas can be suppressed by IL4 which inhibits the synthesis of IL6, a myeloma growth factor. IL4 also inhibits the synthesis of IL6 in human alveolar macrophages.
  • Pretreatment of macrophages with IL4 prevents the production of IL1, TNF-alpha and prostaglandins in response to activation of the cells by bacterial endotoxins or IFN-gamma.
  • IL4 synergises with Epo and G-CSF/Epo in the generation of colonies containing granulocytes or erythroid progenitor cells in a colony formation assay.
  • The classical detection method for IL4 is a B-cell costimulation assay measuring the enhanced proliferation of stimulated purified B-cells. IL4 can be detected also in bioassays, employing IL4-responsive cells (e.g., BALM-4; BCL1; CT.4S; CTL44; CTLL-2; Da; FDCPmix; HT-2; L4; L138.8A; M07E; MC/9; NFS-60; Ramos, Sez627, TF-1; TS1). A specific detection method for human IL4 is the induction of CD23 in a number of B-cell lines with CD23 detected either by flow-through cytometry or by a fluorescence immunoassay. An immunoassay that allows rapid determination of the rate of IN production under conditions preventing consumption/degradation is cytokine immunotrapping.
  • IL4 inhibits the growth of colon and mammary carcinomas. It has been shown to augment the development of LAK cells. The transduction of murine tumor cells with a functional IL4 gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts. Altered tumor cells expressing IL4 also increase systemic immunity. Mice vaccinated with transduced cells reject a subsequent challenge of non-transduced cells, and, in some cases, a pre-existing tumor.
  • Human IL6 is a protein of 185 amino acids glycosylated at positions 73 and 172. It is synthesized as a precursor protein of 212 amino acids. Monocytes express at least five different molecular forms of IL6 with molecular masses of 21.5-28 kDa. They mainly differ by post-translational alterations such as glycosylation and phosphorylation.
  • IL6 isolated from various cell types shows some microheterogeneity in its N terminus. A 42-45 kDa form has been observed in plasma that is probably complexed with a carrier protein, alpha-2-macroglobulin (α2M). Murine and human IL6 show 65% sequence homology at the DNA level and 42% homology at the protein level.
  • IL6 is a member of a family of cytokines which also includes LIF, CNTF, Oncostatin M, IL11, and CT-1. All known members of the IL6 cytokine family induce hepatic expression of acute phase proteins.
  • A stable and highly bioactive designer cytokine consisting of a fusion protein between IL6 and a soluble IL6 receptor, designated H-IL6, has been used for human hematopoietic progenitor cell expansion and is useful in cases in which cells do not respond to IL6 but require a stable complex consisting of IL6 and a soluble IL6 receptor.
  • The human IL6 gene has a length of approximately 5 kb and contains five exons. It maps to human chromosome 7p21-p14 between the markers D7S135 and D7S370. The murine gene maps to chromosome 5. The nucleotide sequences of IL6 and G-CSF genes resemble each other in a way suggesting a possible evolutionary relationship.
  • The IL6 receptor (e.g. polypeptides encoded by Genbank Accession No. M20566, E03515) is expressed on T-cells, mitogen-activated B-cells, peripheral monocytes and some macrophage- and B-cell-derived tumor cell types. It is not expressed in resting B-cells but is in resting T-cells. In hepatocytes the IL6 receptor expression is enhanced after treatment with IL6 or IL1. In several cell types the expression of the IL6 receptor is also enhanced by glucocorticoids. The IL6 receptor gene maps to human chromosome 1q21.
  • The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids. It has been designated CD126. It is synthesized as a precursor of 468 amino acids. The molecular structure resembles that of receptors for M-CSF, PDGF and IL1 in that the receptor contains an immunoglobulin-like sequence domain in the aminoterminal region of the extracellular receptor domain.
  • The intracellular domain of the IL6 receptor has a length of approximately 82 amino acids and does not show any homology to other proteins involved in intracellular signal transduction. Two different forms of the receptor have been described that bind IL6 with different affinities (Kdis=10−9 and 10−11 M) and most likely arise by post-translational modification of the same receptor protein. Biological activities of IL6 have been found also at concentrations of 10−13-10−15 M suggesting either the existence of other high-affinity receptor conformations or the existence of further receptor molecules with higher affinities.
  • IL6 receptor-mediated signal transduction involves protein kinase C and also adenylate cyclase.
  • The complex formed between IL6 and its receptor associates with a transmembrane glycoprotein, gp130 (918 amino acids; cytoplasmic domain of 277 amino acids), that is involved in signal transduction. Binding of IL6 to its receptor leads to disulfide-linked homodimerization of gp130 and the associated activation of a tyrosine kinase as the first step of signal transduction. gp130 is expressed also in cells that do not express IL6 receptors. It has been found to be a component of other receptors, including those for IL11, LIF, Oncostatin M, and CNTF, and CT-1. This explains why LIF, CNTF, and IL6 share many biological activities although the factors themselves are not related to each other. A factor resembling STAT proteins, termed LIL factor, has been found to be involved in signaling pathways of IL6, and also of IL1 and bacterial lipopolysaccharides.
  • A soluble form of the IL6 receptor (IL6R-SUP (IL6 receptor soluble urinary protein)) has been described also that also interacts with gp130. These soluble receptors probably function as physiological regulators of cytokine activities by inhibiting receptor binding or act as transport proteins. Similar soluble receptors or binding proteins have been described also for IL1 (IL1ra, IL1 receptor antagonist), IL2, IL4, IL7, TNF-alpha, IGF, and IFN-gamma.
  • Some cells, including hematopoietic progenitor cells and neuronal cells, are only responsive towards a combination of IL6 and soluble IL6 receptor but not to IL6 alone.
  • Human IL6 is biologically active in monkeys, rats, and mice. Murine IL6 is not active in human cells. The plethora of biological activities is exemplified by the many different acronyms under which IL6 has been described. IL6 is a pleiotropic cytokine influencing antigen-specific immune responses and inflammatory reactions. It is one of the major physiological mediators of cute phase reaction. In hepatocytes IL6 in combination with glucocorticoids induces the synthesis of metallothioneins and increases intracellular zinc levels, thus preventing CCL4-induced hepatotoxicity. IL6 is a neurotrophic factor for cholinergic neurons that promotes their survival in culture. Some neuronal cell lines can be induced to differentiate by IL6.
  • IL6, like IL1, stimulates the synthesis of ACTH (Corticotropin) in the pituitary. Glucocorticoids synthesized in response to ACTH inhibit the production of IL6, IL1 and TNF in vivo, thus establishing a sort of negative feedback loop between the immune system and neuroendocrine functions. In astrocytes IL6 induces the synthesis of Nerve Growth Factor (NGF).
  • IL6 is a B-cell differentiation factor in vivo and in vitro and an activation factor for T-cells. In the presence of IL2 IL6 induces the differentiation of mature and immature T-cells into cytotoxic T-cells. IL6 also induces the proliferation of thymocytes and probably plays a role in the development of thymic T-cells.
  • IL6 is capable of inducing the final maturation of B-cells into immunoglobulin-secreting plasma cells if the cells have been pre-activated by IL4. In B-cells IL6 stimulates the secretion of antibodies to such a degree that serum IgG1 levels can rise 120-400-fold.
  • IL6 at concentrations of only 0.002 ng/mL is one of the major autocrine growth modulator for many human myelomas. The growth of these cells can be inhibited by monoclonal antibodies directed against IL6. It can be inhibited also by the introduction of antisense oligonucleotides against IL6 or by IL4. The growth-inhibitory effects of corticosteroids on myeloma cells is probably due to the steroid-induced reduction in the expression of IL6. The growth of human IL6 dependent myeloma cells can be inhibited also by IFN-gamma. IL6 may also function as an autocrine growth modulator for other tumor types, some of which have been found to secrete IL6 constitutively. IL6 has been shown to be an autocrine modulator of growth for in vitro cervical tumor cell growth. On the other hand IL6 blocks the growth of some solid tumors such as mammary carcinomas, cervical carcinomas, human lung cancer cell lines, histiocytic lymphomas, and melanomas.
  • IL6 and IL3 synergise in vitro in promoting the proliferation of multipotent hematopoietic progenitor cells. IL6 is also a thrombopoietin that induces the maturation of megakaryocytes in vitro and increases platelet counts in vivo. In murine, but not in human bone marrow cultures IL6 shows activities resembling those of GM-CSF.
  • Plasmacytoma cells produce IL6 and also the IL6 receptor. It has been suggested that these cells are stimulated in an autocrine fashion. A paracrine mechanism involving the presence of two different cell populations, one producing the factor and the other expressing the receptor, has been described also.
  • IL6 can be detected in bioassays employing IL6 responsive cell lines (e.g., 7TD1; B19; CESS, KPMM2, KT-3; M1, MH60-BSF-2, M07E; Mono Mac 6; NFS-60; PIL-6; SKW6-C14; T1165; XG-1). IL6 can be assayed also by its activity as a hybridoma growth factor. Sensitive immunoassays and colorimetric tests are also available. An ELISA assay exists for detecting the receptor-associated gp130 protein.
  • In combination with other cytokines (for example, IL2) IL6 may be useful in the treatment of some tumor types. The transduction of murine tumor cells with a functional IL6 gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts. Altered tumor cells expressing IL6 also increase systemic immunity. Mice vaccinated with transduced cells reject a subsequent challenge of non-transduced cells, and, in some cases, a pre-existing tumor.
  • Human IL10 is a homodimeric protein with subunits having a length of 160 amino acids. Human IL10 shows 73% amino acid homology with murine IL10. The human IL10 contains four exons. It is closely related to the product of the BCRF-1 gene (Bam HI C fragment rightward reading frame) of Epstein-Barr virus (84% homology at the protein level). These two proteins are more closely related to each other than human and murine IL10. BCRF-1 has therefore also been called viral IL10 (vIL10). The human IL10 gene maps to chromosome 1. The human IL10 shows 81% homology with murine IL10 at the nucleotide level.
  • A receptor has been identified on murine and human cells by using radiolabeled IL10 (e.g. polypeptides encoded by Genbank Accession No. L12120, U00672). Mouse IL10 is capable of blocking binding of human IL10 to mouse but not human cells. The murine IL10 receptor has been cloned. This receptor is a protein of approximately 110 kDa that binds murine IL10 specifically. This receptor is structurally related to receptors for IFN.
  • IL10 inhibits the synthesis of a number of cytokines such as IFN-gamma, IL2 and TNF-beta in Th1 subpopulations of T-cells but not of Th2 cells. This activity is antagonized by IL4. The inhibitory effect on IFN-gamma production is indirect and appears to be the result of a suppression of IL12 synthesis by accessory cells. In the human system, IL10 is produced by, and down-regulates the function of, Th1 and Th2 cells. In macrophages stimulated by bacterial lipopolysaccharides IL10 inhibits the synthesis of IL1, IL6 and TNF-alpha by promoting, among other things, the degradation of cytokine mRNA. It also leads to an inhibition of antigen presentation. In human monocytes IFN-gamma and IL1 antagonize each other's production and function. IL10 has been shown also to be a physiologic antagonist of IL12.
  • IL10 also inhibits mitogen- or anti-CD3-induced proliferation of T-cells in the presence of accessory cells and reduces the production of IFN-gamma and IL2. Exogenous 1L2 and IL4 inhibit the proliferation-inhibitory effect but do not influence the production of IFN-gamma. In LPS-stimulated macrophages IFN-gamma increases the synthesis of IL6 by inhibiting the production of IL10. IL10 appears to be responsible for most or all of the ability of Th2 supernatants to inhibit cytokine synthesis by Th1 cells.
  • IL10 inhibits secretion of Ig by T-cell-independent antigens induced by IL5 but not that induced by IL2.
  • Murine Ly-1 B cells are the principal source of IL10. In contrast to other B-cells, Ly-1 B-cells express greatly elevated constitutive and inducible levels of IL10. These cells also have the distinctive property of continuous self-replenishment. The continuous treatment of newborn mice with anti-IL10 antibodies leads to a depletion of the Ly-1 B-cells while maintaining a normal population of splenic B-cells. These mice also contain greatly reduced serum immunoglobulin M levels and are also impaired in their antibody responses to specific antigens. IL10 is therefore a regulator of Ly-1 B-cell development. The mechanism of Ly-1 B-cell depletion appears to involve the increased production of IFN-gamma since co-administration of neutralizing anti-IFN-gamma antibodies substantially restores the number of peritoneal-resident Ly-1 B-cells in these mice.
  • IL10 is also a costimulator for the growth of mature and immature thymocytes (together with IL2, IL4 and IL7) and functions as a cytotoxic T-cell differentiation factor, promoting a higher number of IL2-activated cytotoxic T-lymphocyte precursors to proliferate and differentiate into cytotoxic effector cells. IL10 sustains viability of B-cells in vitro and also stimulates B-cells and promotes their differentiation. It enhances the expression of MHC class II antigens on B-cells whereas it inhibits MHC class II expression on monocytes. In B-cells activated via their antigen receptors or via CD40 IL10 induces the secretion of IgG, IgA and IgM. This effect is synergised by IL4 while the synthesis of immunoglobulins induced by IL10 is antagonized by TGF-beta. The activation of macrophages can be prevented by IL10.
  • It has been shown that human IL10 is a potent and specific chemoattractant for human T-lymphocytes. The chemotactic activity is directed towards cells expressing CD8 and not towards CD4 (+)cells. IL10 also inhibits the chemotactic response of CD4 (+)cells, but not of CD8 (+)cells, towards IL8. IL10 can be detected with a sensitive ELISA assay. The murine mast cell line D36 can be used to bioassay human IL10. The intracellular factor can be detected also by flow cytometry.
  • The introduction of an IL10 expression vector into CHO cells has been used to analyze the consequences of local IL10 production in vivo. These altered cells were no longer tumorigenic in nude mice or severe combined immunodeficient SCID mice and also suppressed the growth of equal numbers of co-injected normal CHO cells. While normal CHO tumors are usually substantially infiltrated by macrophages, these were virtually absent within CHO-IL10 tumor tissues, suggesting that IL10 indirectly suppresses tumor growth of certain tumors by inhibiting infiltration of macrophages which may provide tumor growth promoting activity.
  • Human IL12 is a heterodimeric 70 kDa glycoprotein consisting of a 40 kDa subunit (p40, 306 amino acids; 10% carbohydrate) and a 35 kDa subunit (p35, 197 amino acids; 20% carbohydrate) linked by disulfide bonds that are essential for the biological activity of IL12. p40 contains 10 cysteines and a binding site for heparin; p35 contains 7 cysteines.
  • The two subunits of IL12 are not related to any other known proteins. p40 shows some homology with the extracellular domain of the receptor for IL6, and p35 appears to be a homologue of IL6.
  • Bioactive murine and human IL12 fusion proteins combining the two IL12 subunits in a single molecule have been described. This designer cytokine retains antitumor activity in vivo. Flexi 12, a single chain protein retaining all of the biological characteristics of the dimeric recombinant IL12, has also been described.
  • The gene encoding the p40 subunit of IL12 (IL12B) maps to human chromosome 5q31-q33 in the same region that also harbors other cytokine genes. The gene encoding the p35 subunit of IL12 (IL12A) maps to human chromosome 3p 12-q 13.2. The expression of the two genes is regulated independently of each other.
  • The IL12 receptor appears to be a single protein of approximately 110 kDa (e.g. polypeptides encoded by Genbank Accession No. U03187, U23922, U64198, U64199). Up to 1000-9000 high affinity IL12 receptors/cell are expressed on peripheral blood mononuclear cells activated by various T-cell mitogens or by IL2. IL12 receptors are present on activated T-cells expressing CD4 and CD8 and on activated CD56 positive natural killer cells. Resting peripheral blood mononuclear cells, tonsillar B-cells, or tonsillar B-cells activated by anti-IgM/Dx, anti-IgM/Dx+IL2, or SAC+IL2 do not express the receptor. High affinity IL12 receptors are expressed constitutively on a transformed marmoset NK-like cell line, HVS.SILVA 40.
  • Binding of IL12 to its receptor can be prevented by monoclonal antibodies directed against the p40 subunit which therefore contains the binding site. The p40 subunit of IL12 shows homology with the extracellular domain of the IL6 receptor. A virus-encoded homologue of the p40 subunit is EBV-induced gene-3.
  • Human IL12 is not active in murine lymphocytes. Hybrid heterodimers consisting of murine p35 and human p40 subunits retain bioactivity on murine cells; however, the combination of human p35 and murine p40 is completely inactive on murine cells. Murine IL12 is active on both murine and human lymphocytes. The p40 subunit of murine IL12 subunit p40 (IL12p40) has been shown to specifically antagonize the effects of the IL12 heterodimer in different assay systems and to function as an endogenous specific inhibitor for the IL12 heterodimer.
  • IL12 stimulates the proliferation of human lymphoblasts activated by phytohemagglutinin. IL12 activates NK-cells positive for CD56, and this activity is blocked by antibodies specific for TNF-alpha. IL12 promotes specific allogenic CTL reactions. IL12 synergizes also with anti-CD3 antibodies and with allogeneic stimulation in mixed lymphocyte cultures in inducing T-cell proliferation.
  • In peripheral lymphocytes of the Th1 type IL12 induces the synthesis of IFN-gamma and IL2, and TNF. TNF-alpha also appears to be involved in mediating the effects of IL12 on natural killer cells since the effects of IL12 are inhibited by an antibody directed against TNF-alpha. IL12 and TNF-alpha are costimulators for IFN-gamma production with IL12 maximizing the IFN-gamma response; the production of IL12, TNF, and IFN-gamma is inhibited by IL10. In Th2 helper cells IL12 reduces the synthesis of IL4, IL5, and IL10.
  • IL12 synergises with suboptimal amounts of IL2 in promoting the proliferation of mononuclear cells in the peripheral blood and in promoting the generation of LAK cells (lymphokine activated killer cells). Picomolar concentrations of IL12 are as effective as nanomolar concentrations of IL2 in augmenting the cytolytic activity of natural killer cells expanded in vivo by IL2. IL12 also acts as a co-mitogen and potentiates the proliferation of resting peripheral cells induced by IL2.
  • IL12 enhances myelopoiesis of primitive bone marrow progenitor cells induced by SCF (stem cell factor) and synergizes with colony stimulating factors to induce proliferation. IL12 also has synergistic effects on more committed bone marrow progenitors, synergising with IL3, IL11, or IL3 plus SCF.
  • IL12 is potential clinical interest since it allows the reduction of doses of IL2 required for the generation of LAK cells (lymphokine-activated killer cells). IL12 has been shown to inhibit the growth of a variety of experimental tumors in vivo and to have antiangiogenic effects in vivo, which are, at least in part, mediated by IFN-gamma. IL12 therefore seems to be a potential candidate also for the treatment of angiogenesis-dependent malignancies.
  • IL19 and IL10 share 21 percent amino acid identity and are probably homologs. In monocytes treatment with bacterial lipopolysaccharides induces the synthesis of IL19 and this effect is potentiated in the presence of IL4 or IL13 but is unaffected by IFN-gamma. GM-CSF directly induces IL19 gene expression in monocytes. IL19 has been shown to bind to the IL20 receptor complex (Dumoutier L et al Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Journal of Immunology 167(7): 3545-9 (2001); Gallagher G et al Cloning, expression and initial characterization of interleukin-19 (IL-i 9), a novel homologue of human interleukin-10 (IL-10). Genes Immun 1(7): 442-50 (2000)).
  • IL20 is structurally related to IL10. IL20 appears to be an autocrine factor for keratinocytes that regulates their participation in inflammation. Overexpression of IL20 in transgenic mice causes neonatal lethality with skin abnormalities characterized by an impairment of epidermal differentiation (Blumberg H et al Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 104(1): 9-19 (2001); Dumoutier L et al Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Journal of Immunology 167(7): 3545-9 (2001); Rich BE and Kupper TS Cytokines: IL-20-a new effector in skin inflammation. Current Biology 11(13): R531-4 (2001)).
  • An IL20 receptor has been identified to consist of two orphan class 2 cytokine receptor subunits. The receptor is expressed in skin and its expression is upregulated dramatically in psoriatic skin. Engagement of the receptor in a keratinocyte cell line involves signaling by one member of the STAT proteins, STAT3.
  • The IL20 receptor complex has been shown to bind also IL19 and IL24.
  • IL21 has been isolated by Parrish-Novak et al from a cDNA library derived from activated CD3 (+)T-cells in a search for the ligand of a type-I cytokine receptor isolated previously. The cDNA encodes a secreted protein of 131 amino acids protein most closely related to IL2 and IL15. The IL21 gene maps to human chromosome 4q26-q27 near the IL2 gene. IL21 mRNA is expressed in CD4 (+) but not in CD8 (+) T-cells after cell activation. It is not expressed also in B-cells and monocytes (Asao H et al Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. Journal of Immunology 167(1):1-5 (2001); Ozaki K et al Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proceedings of the National Academy of Science (USA) 97: 11439-11444 (2000); Parrish-Novak J et al Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408: 57-63 (2000)).
  • IL21 stimulates proliferation of B-cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL4 plus anti-IgM. IL21 augments stimulation of the proliferation of naive (CD45RA (+)) but not memory (CD45RO (+)) T-cells mediated by engagement of CD3. IL21 stimulates the proliferation of bone marrow progenitor cells and the expression of the NK-cell marker CD56 in the presence of IL15.
  • The IL21 receptor has been isolated by Parrish-Novak et al and found to be expressed by CD23 (+)B-cells, B-cell lines, a T-cell leukemia line, and NK-cell lines. The receptor gene has been mapped to human chromosome 16p12. The same receptor has been isolated by Ozaki et al, who called it NILR (novel interleukin receptor). The receptor (538 amino acids) is most closely related to human IL2 beta receptor. The receptor contains a WSXWS motif in the extracellular region, typical of type-1 cytokine receptors. The receptor is expressed on NK-cells, T-cells, and B-cell lines.
  • The common gamma chain, which is an indispensable subunit of the functional receptor complexes for IL2, IL4, 1L7, IL9, and IL15 has been shows also to be part of the IL21 receptor complex. The functional signalling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3 (Asao et al).
  • IL22 (180 amino acids including a signal sequence; 25 kDa; also called IL-TIF) was identified by a cDNA subtraction method as a gene induced specifically by IL9 in mouse T lymphocytes. The protein shows limited homology with IL10 (22 percent amino acid identity). Human and murine IL-TIF proteins share 79 percent amino acid identity.
  • The murine and human IL-TIF genes both consist of 6 exons. The human single-copy gene maps to chromosome 12q15 (90 Kb from the IFN-gamma gene, and 27 Kb from the AK155 gene encoding another IL10-related cytokine. In mice the gene is located also in the same region as the IFN-gamma gene. In BALB/c and DBA/2 mice the gene is a single copy gene. In C57B1/6, FVB and 129 mice the gene is duplicated. The two copies, termed IL-TIF-alpha and IL-TIF-beta show 98 percent nucleotide identity in the coding region and differ by a deletion of 658 nucleotide in IL-TIF-beta. This gene may be inactive.
  • Expression of IL-TIF is induced by IL9 in thymic lymphomas, T-cells, and mast cells, and by lectins in freshly isolated splenocytes. IL-TIF expression in T-cells does not require protein synthesis, and depends on the activation Janus kinases and STAT proteins. IL-TIF is expressed constitutively in thymus and brain.
  • In HepG2 human hepatoma cells IL-TIF up-regulates the production of acute phase proteins. IL-TIF also acts as a pro-inflammatory cytokine in vivo because injection of the protein also induces the synthesis of acute phase proteins. Synthesis of IL-TIF is induced rapidly after injection of bacterial lipopolysaccharides. In contrast to IL10, IL22 does not inhibit the production of pro-inflammatory cytokines by monocytes in response to bacterial lipopolysaccharides. It also does not impair IL10 function on monocytes. IL-TIF has some inhibitory effects on IL4 production from Th2 T-helper cells.
  • IL10 and IL-TIF utilise a common receptor subunit. Antibodies directed against the beta chain of the IL10 receptor block the induction of acute phase proteins by IL-TIF. The functional IL-TIF receptor complex consists of two receptor chains. One chain has been identified as the orphan receptor CRF2-4 that is expressed in normal liver and kidney. The other chain is the L10 receptor-2, the second chain of the IL10 receptor complex. Monkey COS expressing CRF2-9 alone respond to IL-TIF. In hamster cells both chains must be expressed to yield functional IL-TIF receptors. Although both receptor chains can bind IL-TIF independently binding of IL-TIF to the receptor complex is greater. This sharing of receptor subunits is similar to the shared use of the common gamma chain by cytokines such as IL2, IL4, IL7, IL9, and IL15. Some cell lines that do not respond to IL10 respond to IL-TIF by activation of STAT-1, STAT-3, and STAT-5.
  • A soluble secreted receptor (231 amino acids), designated IL22BP [IL22 binding protein] has been described (Kotenko et al). The protein demonstrates 34 percent amino acid identity with the extracellular domain of the IL22R1 chain and is known also as CRF2-10. The gene maps to human chromosome 6q24, 35 kb from the IFN-gamma R1 gene. It is expressed in various tissues with maximal expression in breast, lungs, and colon. The protein binds IL-TIF and inhibits its activity, blocking its interaction with the cell surface IL22 receptor complex and thus acting as a natural cytokine antagonist. IL22BP also blocks induction of the suppressors of cytokine signaling-3 (SOCS-3) gene expression by IL22 in HepG2 cells (Dumoutier L et al Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. Journal of Immunology 164(4): 1814-1819 (2000); Dumoutier L et al Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proceedings of the National Academy of Science (USA) 97(18): 10144-9 (2000); Dumoutier L et al IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immun 1(8): 488-494 (2000); Dumoutier L et al Cloning and characterization of il-22 binding protein, a natural antagonist of il-10-related t cell-derived inducible factor/il-22. Journal of Immunology 166(12): 7090-5 (2001); Kotenko S V et al Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. Journal of Immunology 166(12): 7096-7103 (2001); Kotenko S V et al Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. Journal of Biological Chemistry 276(4): 2725-32 (2001); Xie M H et al Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. Journal of Biological Chemistry 275(40): 31335-9 (2000)).
  • IL-23 is the name given to a factor that is composed of the p40 subunit of IL12 (IL12B) and another protein of 19 kDa, designated p19. p19 is structurally related to IL6, G-CSF, and the p35 subunit of IL12. In databanks the p19 subunit is found also under the acronym SGRF (IL6 G-CSF related factor).
  • p19 by itself is biologically inactive while the complex of p19 with p40 is active. The active complex is secreted by dendritic cells after cell activation.
  • Mouse memory T-cells (CD4 (+) CD45 Rb(low)) proliferate in response to IL23 but not in response to IL12. Human IL23 has been shown to stimulate the production of IFN-gamma by PHA blast T-cells and memory T-cells. It also induces proliferation of both cell types.
  • IL23 binds to the beta-1 subunit but not to the beta-2 subunit of the IL12 receptor, activating one of the STAT proteins, STAT4, in PHA blast T-cells.
  • Expression of p19 in transgenic mice leads to runting, systemic inflammation, infertility, and death before 3 months of age. The animals show high serum concentrations of the pro-inflammatory cytokines TNF-alpha and IL1. The number of circulating neutrophils is increased. Acute phase proteins are expressed constitutively. Animals expressing p19 specifically in the liver do not show these abnormalities. Expression of p19 is most likely due to hematopoietic cells as bone marrow transplantation of cells expressing p19 causes the same phenotype as that observed in the transgenic animals (Oppmann B et al Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13(5): 715-25 (2000); Wiekowski M T et al Ubiquitous Transgenic Expression of the IL-23 Subunit p 19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death. Journal of Immunology 166(12): 7563-70 (2001)).
  • IL24 is a name given to a protein that is known also as ST16 [suppression of tumorigenicity-16] and MDA-7 [melanoma differentiation-associated gene 7]. The rat counterpart of IL24 has been identified as mob-5 or C49a. The murine counterpart is FISP.
  • MDA-7 protein (206 amino acids) was identified initially as a melanoma differentiation-associated cDNA in a study using cultured human melanoma cells that lose proliferative capacity and terminally differentiate in response to human IFN-beta and mezerein. The expression of MDA-7 is upregulated as a consequence of terminal differentiation. H0-1 and C8161 human melanoma cells engineered to express MDA-7 show reduces growth and do not form colonies in a colony formation assay. MDA-7 selectively suppresses the growth of human breast cancer cells by promoting cell death by apoptosis. Ectopic expression of MDA-7 by means of a replication defective adenovirus results in growth suppression and induction of apoptosis in a broad spectrum of additional cancers, including melanoma, glioblastoma multiforme, osteosarcoma and carcinomas of the breast, cervix, colon, lung, nasopharynx and prostate. No apparent harmful effects are observed after expression of MDA-7 in normal epithelial or fibroblast cells.
  • In human hematopoietic cells MDA-7 expression is induced during megakaryocyte differentiation in response to treatment with TPA (12-O-tetradecanoyl-phorbol-13-acetate).
  • The human MDA-7 gene maps to chromosome 1q32 and is tightly linked (within a region of 195 kb) to the genes encoding IL10, IL19, and IL20.
  • The receptor for IL24 has been identified as the IL20 receptor complex. This receptor also binds to IL19 (Blumberg H et al Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 104(1): 9-19 (2001); Dumoutier L et al Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Journal of Immunology 167(7): 3545-9 (2001); Huang E Y et al Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. Oncogene 20(48): 7051-63 (2001); Jiang H et al Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11: 2477-2486 (1995); Jiang H et al The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proceedings of the National Academy of Science (USA) 93: 9160-9165 (1996); Su Z et al The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proceedings of the National Academy of Science (USA) 95: 14400-14405 (1998)).
  • IL25 (also known as SF20) has been identified in a search for factors that stimulate cell proliferation. The factor is secreted by bone marrow stromal cells
  • The IL25 receptor has been identified as mouse thymic shared antigen-1 (TSA-1). Enforced expression of the receptor in one of the factor-dependent cell lines, BaF3, which does not express the receptor, causes cell proliferation. FDCP2 cells, which express the receptor, also proliferate in response to SF20/IL25. In both cases proliferation is abolished by specific blocking antibodies directed against the receptor.
  • SF20/IL-25 has no detectable myelopoietic activity but supports proliferation of cells in the lymphoid lineage (Tulin E E et al SF20/IL-25, a Novel Bone Marrow Stroma-Derived Growth Factor That Binds to Mouse Thymic Shared Antigen-1 and Supports Lymphoid Cell Proliferation. Journal of Immunology 167(11): 6338-47 (2001)).
  • The members of the TNF ligand superfamily (TNFalpha, TNF-beta, LT beta, CD27 ligand, CD30 ligand, CD40 ligand, CD95 ligand, 41BB, OX40 ligand, TRAIL) share common biological activities, but some properties are shared by only some ligands, while others are unique. Human TNF-alpha is a non-glycosylated protein of 17 kDa and a length of 157 amino acids. Murine TNF-alpha is N-glycosylated. Homology with TNF-beta is approximately 30%. TNF-alpha forms dimers and trimers. The 17 kDa form of the factor is produced by processing of a precursor protein of 233 amino acids. A TNF-alpha converting enzyme has been shown to mediate this conversion. A transmembrane form of 26 kDa has been described also.
  • TNF-alpha contains a single disulfide bond that can be destroyed without altering the biological activity of the factor. Mutations Ala84 to Val and Val91 to Ala reduce the cytotoxic activity of the factor almost completely. These sites are involved in receptor binding. The deletion of 7 N-terminal amino acids and the replacement of Pro8Ser9Asp10 by ArgLysArg yields a mutated factor with an approximately 10-fold enhanced antitumor activity and increased receptor binding, as demonstrated by the L-M cell assay, while at the same time reducing the toxicity.
  • The gene has a length of approximately 3.6 kb and contains four exons. The primary transcript has a length of 2762 nucleotides and encodes a precursor protein of 233 amino acids. The aminoterminal 78 amino acids function as a presequence. The human gene maps to chromosome 6p23-6q12. It is located between class I HLA region for HLA-B and the gene encoding complement factor C. The gene encoding TNF-beta is approximately 1.2 kb downstream of the TNF-alpha gene. However, both genes are regulated independently. The two genes also lie close to each other on murine chromosome 17.
  • Approximately 500-10000 high-affinity receptors (Ka=2.5×10−9 M) for ‘I’ N-alpha are expressed on all somatic cell types with the exception of erythrocytes. Two receptors of 55 kDa (TNF-R1; new designation: CD120a) (e.g. polypeptides encoded by Genbank Accession No. X55313) and 75 kDa (TNF-R2; new designation: CD120b) (e.g. as described in Goodwin R G et al (1991) Molecular Cellular Biology 11: 3020-6) have been described. One receptor is a glycosylated protein of 455 amino acids that contains an extracellular domain of 171 and a cytoplasmic domain of 221 amino acids. Sequence homologies in the cysteine-rich domains of the extracellular portion reveal that the receptor is related to the low-affinity receptor of NGF and to human cell surface antigen CD40.
  • Deletion analysis in the C-terminal intracellular region of the 55 kDa receptor, TNF-R1 has revealed the existence of a so-called death domain, which is involved in signaling processes leading to programmed cell death. The death domain of TNF-R1 interacts with a variety of other signaling adaptor molecules, including TRADD, and RIP.
  • The two known receptors bind both TNF-alpha and TNF-beta. p55 is expressed particularly on cells susceptible to the cytotoxic action of TNF. p75 is also present on many cell types, especially those of myeloid origin (a virus-encoded homologue of the receptor subunit is EBV-induced gene-6). It is strongly expressed on stimulated T-cells and B-lymphocytes. The differential activities of TNF on various cell types, i.e. growth-promoting and growth-inhibiting activities, are probably mediated by the differential expression and/or regulation of multiple receptors in combination with other distinct receptor-associated proteins. p55 appears to play a critical role in host defenses against microorganisms and their pathogenic factors.
  • A third receptor subtype is expressed in normal human liver. It binds TNF-alpha but not TNF-beta. Some viruses contain genes encoding secreted proteins with TNF binding properties that are closely homologous to the p55 and p75 TNF receptors. Differential effects of the two receptor subtypes have been found also in TNF-mediated adhesion of leukocytes to the endothelium. It appears that engagement of the p55 receptor specifically leads to the induction of the cellular adhesion molecules ICAM-1, E-selectin, V-CAM-1, and CD44, while engagement of both the p55 and the p75 receptor induces expression of alpha-2 integrin.
  • Truncated soluble forms of the receptor have been found also. The soluble forms, in particular the soluble extracellular domain of the p60 receptor, block the antiproliferative effects of TNF and, therefore, may modulate the harmful effects of TNF.
  • Receptor densities are reduced by IL1 and tumor promoters such as phorbol esters. The expression of TNF-alpha receptor density is induced by IFN-alpha, IFN-beta, and IFN-gamma.
  • Signal transducers that associate with the cytoplasmic domains of members of the TNF receptor superfamily comprise TRAF (Tumor necrosis factor receptor-associated factors).
  • Human TNF-alpha is active on murine cells with a slightly reduced specific activity. In general, TNF-alpha and TNF-beta display similar spectra of biological activities in in-vitro systems, although TNF-beta is often less potent or displays apparent partial agonist activity.
  • TNF-alpha shows a wide spectrum of biological activities. It causes cytolysis and cytostasis of many tumor cell lines in vitro. Sensitive cells die within hours after exposure to picomolar concentrations of the factor and this involves, at least in part, mitochondria-derived second messenger molecules serving as common mediators of TNF cytotoxic and gene-regulatory signaling pathways. The factor induces hemorrhagic necrosis of transplanted tumors. Within hours after injection TNF-alpha leads to the destruction of small blood vessels within malignant tumors. The factor also enhances phagocytosis and cytotoxicity in neutrophilic granulocytes and also modulates the expression of many other proteins, including fos, myc, IL1 and IL6.
  • The 26 kDa form of TNF is found predominantly on activated monocytes and T-cells. It is also biologically active and mediates cell destruction by direct cell-to-cell contacts.
  • The chemotactic properties of fMLP (Formyl-Met-Leu-Phe) for neutrophils are enhanced by TNF-alpha. TNF-alpha induces the synthesis of a number of chemoattractant cytokines, including IP-10, JE, KC, in a cell-type and tissue-specific manner.
  • TNF-alpha is a growth factor for normal human diploid fibroblasts. It promotes the synthesis of collagenase and prostaglandin E2 in fibroblasts. It may also function as an autocrine growth modulator for human chronic lymphocytic leukemia cells in vivo and has been described to be an autocrine growth modulator for neuroblastoma cells. The autocrine growth-promoting activity is inhibited by IL4.
  • In resting macrophages TNF induces the synthesis of IL1 and prostaglandin E2. It also stimulates phagocytosis and the synthesis of superoxide dismutase in macrophages. TNF activates osteoclasts and thus induces bone resorption.
  • In leukocyte and lymphocyte progenitors TNF stimulates the expression of class I and II HLA and differentiation antigens, and the production of IL1, colony stimulating factors, IFN-gamma, and arachidonic acid metabolism. It also stimulates the biosynthesis of collagenases in endothelial cells and synovial cells.
  • IL6 suppresses the synthesis of IL1 induced by bacterial endotoxins and TNF, and the synthesis of TNF induced by endotoxins.
  • The neurotransmitter SP (substance P) induces the synthesis of TNF and IL1 in macrophages. IL1, like IL6, stimulates the synthesis of ACTH (corticotropin) in the pituitary. Glucocorticoids synthesized in response to ACTH in turn inhibit the synthesis of IL6, IL1 and TNF in vivo, thus establishing a negative feedback loop between the immune system and neuroendocrine functions.
  • TNF-alpha enhances the proliferation of T-cells induced by various stimuli in the absence of IL2. Some subpopulations of T-cells only respond to IL2 in the presence of TNF-alpha. In The presence of IL2 TNF-alpha promotes the proliferation and differentiation of B-cells.
  • The functional capacities of skin Langerhans cells are also influenced by TNF-alpha. These cells are not capable of initiating primary immune responses such as contact sensibilisation. They are converted into immunostimulatory dendritic cells by GM-CSF and also IL1. These cells therefore are a reservoir for immunologically immature lymphoid dendritic cells. The enhanced ability of maturated Langerhans cells to process antigens is significantly reduced by TNF-alpha.
  • Although TNF-alpha is also required for normal immune responses the overexpression has severe pathological consequences. TNF-alpha is the major mediator of cachexia observed in tumor patients (hence its name, cachectin). TNF is also responsible for some of the severe effects during Gram-negative sepsis.
  • TNF-alpha can be detected in bioassays involving cell lines that respond to it (e.g., BT-20, CT6, EL4; PK15; L929; L-M; M07E; T1165; WEHI-3B). TNF-alpha can be detected also by a sensitive sandwich enzyme immunoassay, ELISA, an immunoradiometric assay (IRMA), and by an assay designated RELAY (receptor-mediated label-transfer assay). Intracellular factor is detected by two color immunofluorescence flow cytometry. Higuchi et al have described an assay based on the release of tritiated thymidine from cells undergoing apoptosis after treatment with either TNF-alpha or TNF-beta. IFN-alpha, IFN-beta, IFN-gamma, TGF-beta, IL4, LIF and GM-CSF have been shown not to interfere with this assay.
  • In contrast to chemotherapeutic drugs TNF specifically attacks malignant cells. Extensive preclinical studies have documented a direct cytostatic and cytotoxic effect of TNF-alpha against subcutaneous human xenografts and lymph node metastases in nude mice, as well as a variety of immunomodulatory effects on various immune effector cells, including neutrophils, macrophages, and T-cells. Single- and multiple-dose phase I studies have confirmed that TNF can be administered safely to patients with advanced malignancies in a dose range associated with anticancer effect without concomitant serious toxicities such as shock and cachexia. However, clinical trials on the whole have unfortunately so far failed to demonstrate significant improvements in cancer treatment, with TNF-induced systemic toxicity being a major limitation for the use of TNF as an antineoplastic agent in most cases. The combined use of TNF and cytotoxic or immune modulatory agents, particularly IFN-gamma and possibly IL2, may be of advantage in the treatment of some tumors. In some cases intratumoral application of TNF has been found to be of advantage in tumor control.
  • Some mutant forms of TNF-beta with selective activity on the p55 receptor have been described recently. It has been shown that activation of the p55 receptor is sufficient to trigger cytotoxic activity towards transformed cells. Some of these mutants have been described to retain their antitumor activity in nude mice carrying transplanted human tumors.
  • TNF can also be used to increase the aggressiveness of lymphokine-activated killer cells. Studies with an experimental fibrosarcoma metastasis model have shown that TNF induces significant enhancement of the number of metastases in the lung. It has been suggested that low doses of endogenous TNF or administration of TNF during cytokine therapy may enhance the metastatic potential of circulating tumor cells. The transduction of murine tumor cells with a functional TNF-alpha gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts.
  • The interferons are a family of cytokines that induce a virus-nonspecific antiviral state in target cells. Binding of an interferon to its receptor induces new protein synthesis which, in turn, results in the inactivation of initiation factor eIF-2. The inactivation is thought to contribute to the antiviral state induced by the interferons. Interferons also induce pathways that activate intracellular endonucleases which degrade viral mRNA. Many interferons also possess immunomodulatory activities, such as activation of macrophages and lymphocytes. Examples of interferons include IFN-gamma (e.g. polypeptides encoded by Genbank Accession No. K01900, J00209, M12350, J00213, J00216, J00214, M11003, M11026, M34913, M54886, X01974, L38698, M13710, K01238, M13660, M68944, X01972, X01971, X01973, X01969), IFN-gamma (e.g. polypeptides encoded by Genbank Accession No.M28622, X14029, X14455, K00020, J00218, E00171, X04430, A09363, M27327, M16656, M25460, K03196), IFN-gamma e.g. polypeptides encoded by Genbank Accession No. A34532, X87308, E00756, K00083), IFN-gamma e.g. polypeptides encoded by Genbank Accession No. X58822, A12140), bovine trophoblast protein-1 (IFN-gamma) e.g. polypeptides encoded by Genbank Accession No. M31556, M31557, M31558), and their homologues among species. Human IFN-gamma and IFN-gamma are thought to bind to a common receptor (e.g. polypeptides encoded by Genbank Accession No. X60459, M89641) which is distinct from the receptor for IFN-gamma (e.g. polypeptides encoded by Genbank Accession No. J03143, M28233).
  • At least 23 different variants of IFN-alpha are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172
  • amino acids. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end. Disulfide bonds are formed between cysteines at positions 1/98 and 29/138. The disulfide bond 29/138 is essential for biological activity while the 1/98 bond can be reduces without affecting bioactivity.
  • Human IFN-beta is a glycoprotein (approximately 20% sugar moiety) of 20 kDa and has a length of 166 amino acids. Glycosylation is not required for biological activity in vitro. The protein contains a disulfide bond Cys31/141) required for biological activity. At the DNA level IFN-beta displays 34% sequence homology with IFN-beta-2 and approximately 30% homology with other IFN-alpha subtypes. In contrast to IFN-gamma IFN-beta is stable at pH2.
  • Human IFN-gamma is a dimeric protein with subunits of 146 amino acids. The protein is glycosylated at two sites. The pI is 8.3-8.5. IFN-gamma is synthesized as a precursor protein of 166 amino acids including a secretory signal sequence of 23 amino acids. Two molecular forms of the biologically active protein of 20 and 25 kDa have been described. Both of them are glycosylated at position 25. The 25 kDa form is also glycosylated at position 97. The observed differences of natural IFN-gamma with respect to molecular mass and charge are due to variable glycosylation patterns. 40-60 kDa forms observed under non-denaturing conditions are dimers and tetramers of IFN-gamma.
  • Members of the CSF family of cytokines allow the growth and differentiation of bone marrow cells immobilized on soft agar or methylcellulose. While hematopoietic progenitor cells can be maintained only for short periods of time in the absence of such factors, their presence allows the development of colonies containing erythroid cells, neutrophils, eosinophils, macrophages, and/or megakaryocytes, depending on the particular factor. The biochemical analysis of various activities stimulating colony formation supporting the growth and development of these cell types revealed that there existed many different and distinct factors of this sort.
  • Many of these factors are either N- or O-glycosylated. Glycosylation has been shown to enhance the solubility, stability and resistance to proteolytic enzymes. It does not appear to be required for the full spectrum of biological activities of these factors. The genes encoding many of the human colony stimulating factors have been cloned and mapped. Some of the genes are in close vicinity but they do not show great homology among each other with the exception of some conserved regions.
  • Colony stimulating factors are produced by many different cell types, including, for example, B-lymphocytes, epithelial cells, fibroblasts, endothelial cells, macrophages, Stromal cell line, T-lymphocytes. They are synthesized as precursor molecules containing a classical hydrophobic secretory signal sequence of approximately 25-32 amino acids. The secreted factors have an extremely high specific biological activity are active at very low concentrations (1-100 pM). These factors are absolutely required for the proliferation of hematopoietic progenitor cells. The concentrations required for mere maintenance of viability are usually orders of magnitude lower than those required to induce cell proliferation or to elicit specific functional activities of the cells.
  • The names of the individual factors usually indicate the cell types that respond to these factors. The classical colony stimulating factors include M-CSF (e.g. polypeptides encoded by Genbank Accession No. E03235, M64592, U22386, X05010) (macrophage-specific), G-CSF (granulocyte-specific), GM-CSF (macrophage/granulocyte-specific), IL3 (multifunctional) and MEG-CSF (e.g. polypeptides encoded by Genbank Accession No.D86370, U70136) (megakaryocyte-specific). G-CSF and M-CSF are lineage-specific while GM-CSF and IL3 are multifunctional hematopoietic growth factors acting on earlier stages of differentiation of hematopoietic progenitor cells.
  • Human GM-CSF is a monomeric protein of 127 amino acids with two glycosylation sites. The protein is synthesized as a precursor of 144 amino acids, which included a hydrophobic secretory signal sequence at the aminoterminal end. The sugar moiety is not required for the full spectrum of biological activities. Non-glycosylated and glycosylated GM-CSF show the same activities in vitro. Fully glycosylated GM-CSF is biologically more active in vivo than the non-glycosylated protein. The different molecular weight forms of GM-CSF (14 kDa, 35 kDa) described in the literature are the result of varying degrees of glycosylation. GM-CSF contains four cysteine residues (positions 54/96 and 88/121).
  • A comparison of the protein sequence of GM-CSF with those of the other colony stimulating factors reveals that they are not strongly homologous to each other. Human and murine GM-CSF display 60% homology at the protein level and 70% at the nucleotide level. The two factors do not, however, cross-react immunologically. GM-CSF can be associated with the extracellular matrix of cells as a complex with heparan sulfate proteoglycans. This allows storage of the factor in a biologically inactive form. The exact mechanism by which the factor is eventually released from these depots is not known.
  • The human gene has a length of approximately 2.5 kb and contains four exons. The distance between the GM-CSF gene and the IL3 gene is approximately 9 kb. The human GM-CSF gene maps to chromosome 5q22-31 in the vicinity of other genes encoding hematopoietic growth factors (M-CSF, IL3, IL4, IL5) and the gene encoding the M-CSF receptor. The 5′ region of the GM-CSF gene contains several sequence elements known as CLE (conserved lymphokine element). They function as binding sites for transcription factors, modulating the expression of the GM-CSF gene.
  • GM-CSF receptors are expressed at densities of several 100 to several 1000 copies/cell on the cell surface of myeloid cells. The receptor is expressed also on non-hematopoietic cells such as endothelial cells and small cell lung carcinoma cells. In receptor-positive cell lineages the receptor density decreases with increasing degrees of maturation.
  • The receptor shows significant homologies with other receptors for hematopoietic growth factors, including IL2-beta, IL3, IL6, IL7, Epo and the prolactin receptors. One cloned subunit of the GM-CSF receptor (GM-R alpha, 45 kDa) binds GM-CSF with low affinity (e.g. polypeptides encoded by Genbank Accession No. SEG_HUMGRAS). The second subunit (GM-R beta, 120 kDa) does not bind GM-CSF. GM-R alpha is a protein of 400 amino acids that contains only a short cytoplasmic domain of 54 amino acids. The high affinity GM-CSF receptor is formed by the aggregation of the two receptor subunits. The GM-R beta subunit of the receptor (e.g. polypeptides encoded by Genbank Accession No. SEG_MUSAIC2B, M59941) is also a constituent of other cytokine receptor systems. It is a component of the high affinity receptors for IL3 and IL5, both of which also contain a cytokine-specific subunit (AIC2A).
  • Human GM-CSF is not active on murine cells and vice versa. GM-CSF was isolated initially as a factor stimulating the growth of macrophage/granulocyte-containing colonies in soft agar cultures (colony formation assay). GM-CSF is indispensable for the growth and development of granulocyte and macrophage progenitor cells. It stimulates myeloblasts and monoblasts and triggers irreversible differentiation of these cells. GM-CSF synergises with Epo in the proliferation of erythroid and megakaryocytic progenitor cells. In combination with another colony stimulating factor, M-CSF, one observes the phenomenon of synergistic suppression, i.e., the combination of these two factors leads to a partial suppression of the generation of macrophage-containing cell colonies.
  • For some types of blast cells from patients with acute myeloid leukemia GM-CSF acts as an autocrine mediator of growth. GM-CSF is a strong chemoattractant for neutrophils. It enhances microbicidal activity, oxidative metabolism, and phagocytotic activity of neutrophils and macrophages. It also improves the cytotoxicity of these cells. GM-CSF displays a less pronounced specificity than, for example, G-CSF. It stimulates the proliferation and differentiation of neutrophilic, eosinophilic, and monocytic lineages. It also functionally activates the corresponding mature forms, enhancing, for example, the expression of certain cell surface adhesion proteins (CD-11A, CD-11C). The overexpression of these proteins could be one explanation for the observed local accumulation of granulocytes at sites of inflammation. In addition, GM-CSF also enhances expression of receptors for fMLP (Formyl-Met-Leu-Phe) which is a stimulator of neutrophil activity.
  • At pico to nanomolar concentrations GM-CSF is chemotactic for eosinophils and also influences the chemotactic behavior of these cells in response to other chemotactic factors.
  • In granulocytes GM-CSF stimulates the release of arachidonic acid metabolites and the increased generation of reactive oxygen species. The activation of the Na+/H+ antiport system leads to a rapid alkalization of the cytosol. Phagocytotic activities of neutrophil granulocytes and the cytotoxicity of eosinophils is also enhanced considerably by GM-CSF. Since GM-CSF is produced by cells (T-lymphocytes, tissue macrophages, endothelial cells, mast cells) present at sites of inflammatory responses it can be assumed that it is an important mediator for inflammatory reactions.
  • The functional state of Langerhans cells of the skin is also influenced by GM-CSF. These cells are not capable of initiating primary immune responses, for example, contact sensibilization. They are converted to highly potent immunostimulatory dendritic cells by GM-CSF (and also IL1). Langerhans cells therefore form an in situ reservoir for immunologically immature lymphoid dendritic cells. The maturation of these cells which is seen as an increased ability to process antigens, can be down-regulated by TNF-alpha.
  • At nanomolar concentrations GM-CSF induces the expression of complement C3a receptors on basophils. Cells which normally do not respond to C3a and which have been activated by GM-CSF degranulate in response to the C3a stimulus. This is accompanied by the release of histamine and leukotriene C4. This process may be of significance in hypersensitivity reactions associated with inflammatory responses (T-lymphocytes, tissue macrophages, endothelial cells, mast cells). GM-CSF has been shown also to be a potent inducer of trophoblast interferon (TP-1).
  • GM-CSF synergises with some other cytokines, including IL1, IL3 and G-CSF. GM-CSF and G-CSF must act in concert to allow the development of neutrophil-containing colonies in vitro.
  • IL3 by itself only negligibly expands the number of circulating blood cells; a subsequent dose of GM-CSF, however, significantly increases cell numbers, probably because IL3 first leads to an expansion of those cells capable of responding to GM-CSF.
  • The observations that most IL3-dependent cell lines can also grow in the presence of GM-CSF and IL4 and that several synergistic effects are observed between GM-CSF and IL4 suggest that these three factors perform similar functions in controlling the growth of cells. There are some indications that the mechanism of signal transduction contains at least some common factors.
  • Experiments with tyrosine-specific protein kinases encoded by an oncogene have shown that the expression of this kinase activity in factor-dependent cells abolishes their dependence on GM-CSF, IL3 and IL4. The exact mechanism by which these factors regulate the proliferation and differentiation of cells is still unknown.
  • The consequences of a deregulated expression of GM-CSF have been studied in transgenic mice harboring a constitutively expressed GM-CSF gene. The overexpression of the transgene encoding GM-CSF leads to pathological alterations in the retina and causes blindness and also causes muscle deterioration. These mice are characterized by a very pronounced increase in activated macrophages. In addition, the overexpression of GM-CSF leads to the activation of mature macrophages secreting large amounts of IL1 and TNF, suggesting that these cytokines may be responsible for some aspects of the transgenic mouse disease.
  • Histopathological examination demonstrates a pronounced increase in the progenitor cell population of the monocytic lineage. GM-CSF-transgenic animals usually die within months from the massive tissue damage resulting from the overexpression of these factors. Similar results have been obtained with mice possessing a bone marrow manipulated to overexpress GM-CSF by transformation with suitable retrovirus vectors. These findings do not seem to be of clinical significance, though. The long-term treatment of primates and mice with GM-CSF has shown that life-threatening complications do not occur.
  • The biological consequences of GM-CSF gene disruption have been studied in mice generated from ES cells carrying a targeted deletion of the gene. Mice homozygous for a targeted disruption of the GM-CSF gene are characterized by an unimpaired steady-state hematopoiesis, demonstrating that GM-CSF is not essential for maintaining normal levels of the major types of mature hematopoietic cells and their precursors in blood, marrow, and spleen.
  • Most GM-CSF-deficient mice are superficially healthy and fertile but develop abnormal lungs. GM-CSF-deficient mice develop a progressive accumulation of surfactant lipids and proteins in the alveolar space, the defining characteristics of the idiopathic human disorder pulmonary alveolar proteinosis. Extensive lymphoid hyperplasia associated with lung airways and blood vessels is found also. These results demonstrate an unexpected, critical role for GM-CSF in pulmonary homeostasis.
  • Transgenic mice homozygous for null mutations of the gene encoding the common beta subunit (beta C) of the GM-CSF, IL3, and IL5 receptor complexes exhibit normal development and survive to young adult life. They develop pulmonary peribroncnovascular lymphoid infiltrates and areas resembling alveolar proteinosis. Eosinophil numbers in peripheral blood and bone marrow of homozygous deletion mutants are reduced, while other hematological parameters are normal. Bone marrow cells from homozygous deletion mutants do not show high-affinity binding of GM-CSF, while cells from heterozygous animals show an intermediate number of high-affinity receptors. In clonal cultures of bone marrow cells derived from homozygous deletion mutants, even high concentrations of GM-CSF and IL5 do not stimulate colony formation in the colony formation assay. Differences in the systemic clearance and distribution of GM-CSF between mutant and wild-type littermates are not observed.
  • Nishinakamura et al have crossed beta-c mutant mice with mice deficient for IL3. The double-mutant mice lacking all IL3, GM-CSF, and IL5 functions are apparently normally fertile. The animals show the same reduced numbers of eosinophils and a lack of eosinophilic response to parasites as beta-c mutant mice. The immune response of the double mutant mice to Listeria monocytogenes is normal. Hematopoietic recovery after treatment with fluorouracil is also normal. These findings suggest the existence of alternative mechanism to produce blood cells that do not depend on the presence of IL3, GM-CSF, and IL5.
  • GM-CSF can be assayed in a colony formation assay by the development of colonies containing macrophages, neutrophils, eosinophils, and megakaryocytes. GM-CSF is also detected in specific bioassays with cells lines that depend in their growth on the presence of GM-CSF or that respond to this factor (e.g., AML-193; B6SUt-A; BAC1.2F5; BCL1; Da; FDCP1; GF-D8; GM/SO; IC-2; M07E; NFS-60; PT-18; TALL-103; TF-1; UT-7).
  • GM-CSF can be employed for the physiological reconstitution of hematopoiesis in all diseases characterized either by an aberrant maturation of blood cells or by a reduced production of leukocytes. The main and most important clinical application of GM-CSF is probably the treatment of life-threatening neutropenia following chemo and/or radiotherapy, which is markedly reduced under GM-CSF treatment. GM-CSF can be used also to correct chemotherapy-induced cytopenias and to counteract cytopenia-related predisposition to infections and hemorrhages.
  • In order to avoid potential complications following the administration of GM-CSF careful clinical monitoring is required in certain patient groups, for example those with myelodysplastic syndrome, acute myeloid leukemia, inflammatory disease, autoimmune thrombocytopenia or malfunctional immunological responsiveness.
  • Several studies have demonstrated that the use of GM-CSF enhances tolerance to cytotoxic drug treatment and can be used to prevent dose reductions necessitated by the side effects of cytotoxic drug treatment. GM-CSF treatment frequently permits to increase the doses of cytotoxic drugs per course. These studies have also revealed a significantly reduced morbidity under GM-CSF treatment.
  • The transduction of murine tumor cells with a functional GM-CSF gene has been shown to lead to the rejection of the genetically modified cells by syngeneic hosts. Moreover, vaccination with GM-CSF transduced tumor cells prevents growth of a subsequent inoculum of wild-type syngeneic tumor cells.
  • The chemokine family of cytokines consists of relatively small, structurally similar polypeptides that induce chemotaxis in leukocytes. Chemokines have molecular masses of 8-10 kDa and show approximately 20-50% sequence homology among each other at the protein level. The proteins also share common gene structures and tertiary structures. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.
  • According to the chromosomal locations of individual genes two different subfamilies of chemokines are distinguished. Members of the alpha-chemokines are referred to also as the 4q chemokine family because the genes encoding members of this family map to human chromosome 4q12-21. The first two cysteine residues of members of this family are separated by a single amino acids and these proteins, therefore, are called also C-X-C chemokines. This subfamily includes 9E3 (e.g. Genbank protein P08317), AMCF (e.g. polypeptides encoded by Genbank Accession No. M99367, M99368), beta-thromboglobulin (e.g. as disclosed in Begg G S et al (1978), Biochemistry 17: 1739-44), CINC family members (e.g. polypeptides encoded by Genbank Accession No. D21095), ENA-78 (e.g. polypeptides encoded by Genbank Accession No. X78686), eotaxin (e.g. polypeptides encoded by Genbank Accession No. U46572, U40672), GCP-2 (e.g. polypeptides encoded by Genbank Accession No. Y08770, U83303), IL8, IP-10 (e.g. polypeptides encoded by Genbank Accession No. L07417, X02530), KC (e.g. polypeptides encoded by Genbank Accession No. J04596), LIX (e.g. polypeptides encoded by Genbank Accession No. U27267), mig (e.g. polypeptides encoded by Genbank Accession No. M34815, Z24725), MGSA (e.g. polypeptides encoded by Genbank Accession No. X12510), mob-1 (e.g. polypeptides encoded by Genbank Accession No. U17035), NAP-2 (as described in Clark-Lewis I et al (1991) Biochemistry 30: 3128-35, Cohen A B et al (1992) American Journal of Physiology 263: L249-56), NAP-3 (as described in: Schröder J M et al (1991) Journal of Experimental Medicine 171: 1091-100), NAP-4 (as described in Schröder T M et al (1990) Biochemical zui Biophysical Research Communications 172: 898-904), PBSF (SDF) (e.g. polypeptides encoded by Genbank Accession No. D21072, U16752, D50645), and PF4 (e.g. polypeptides encoded by Genbank Accession No. M25897).
  • IL8, MGSA, mouse KC, MIP-2 (e.g. polypeptides encoded by Genbank Accession No. X65647 and as described in Blum S et al Three human homologues of a murine gene encoding an inhibitor of stem cell proliferation. DNA Cell Biol. 9: 589-602 (1990); Clements J M et al Biological and structural properties of MIP-1 alpha expressed in yeast. Cytokine 4: 76-82 (1992); Devatelis G et al Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties. Journal of Experimental Medicine 167: 1939-44 (1988) (erratum in JEM 170: 2189 (1989)); Farber J M A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proceedings of the National Academy of Science (USA) 87: 5238-42 (1990); Haskill S et al Identification of three related human GRO genes encoding cytokine functions. Proceedings of the National Academy of Science (USA) 87: 7732-6 (1990); Poltorak A N et al (1995) Journal of Inflammation 45(3): 207-19; Rossi D L et al (1997) Journal of Immunology 158(3): 1033-1036; Sherry B et al (1988) Journal of Experimental Medicine 168: 2251-9; Tekamp-Olson P et al (1990) Journal of Experimental Medicine 172: 911-9; Wolpe S D et al (1989) Proceedings of the National Academy of Science (USA) 86: 612-16; Wolpe S D et al (1989) FASEB Journal 3: 2565-73), NAP-2, ENA-78, and GCP-2 comprise a subgroup of the human C-X-C-chemokines defined by the conserved ELR sequence motif (glutamic acid-leucine-arginine) immediately preceding the first cysteine residue near the amino-terminal end. Chemokines with an ELR sequence motif have been found to chemoattract and activate primarily neutrophils. Chemokines without the ELR sequence motif appear to chemoattract and activate monocytes, dendritic cells, T-cells, NK-cells, B-lymphocytes, basophils, and eosinophils.
  • Members of the beta-chemokines or 17q chemokine family map to human chromosome 17q11-32 (murine chromosomel 1). The first two cysteine residues are adjacent and, therefore, these proteins are called also C-C chemokines. This subfamily includes ACT-2 (e.g. polypeptides encoded by Genbank Accession No. J04130), CdO (e.g. as described in Berger M S et al (1993) DNA Cell Biol. 12: 839-47. Berger M S et al (1996) δ: 439-447), CCF18 (e.g. as described in Hara T et al (1995) Journal of Immunology 155: 5352-8), DC-CK1 (e.g. as described in Adema G J et al (1997) Nature 387: 713-717), ELC (e.g. polypeptides encoded by Genbank Accession No. AB000887, AF059208), Eotaxin-2 (e.g. as described in Forssmann U et al (1997) Journal of Experimental Medicine 185: 2171-2176), Exodus (e.g. polypeptides encoded by Genbank Accession No. U64197, U88320, U88321, U88322), FIC (e.g. polypeptides encoded by Genbank Accession No. L04694), GDCF and GDCF-2 (e.g. as described in Kuratsu J et al (1989) Journal of the National Cancer Institute 81: 347-51; Yoshimura T et al (1989) Journal of Experimental Medicine 169: 1449-59; Yoshimura T et al (1989) Journal of Immunology 142: 1956-62), HC-21 (e.g. as described in Chang H C & Reinherz E L (1989) European Journal of Immunology 19:1045-1051), HCC-1 (e.g. polypeptides encoded by Genbank Accession No. Z49270), I-309 (e.g. polypeptides encoded by Genbank Accession No. M57502), JE (e.g. polypeptides encoded by Genbank Accession No. AF058786, M28226), LAG-1 (lymphocyte activation gene-1) (e.g. polypeptides encoded by Genbank Accession No. X53683), LARC D86955), LD78 E03130, E03131, MARC (e.g. as described in Thirion S et al (1994) Biochemical and Biophysical Research Communications 201: 493-499), MCAF M24545 and as described in Apella E et al (1990) Progress in Clinical and Biological Research 349: 405-17), MCP-1 (e.g. polypeptides encoded by Genbank Accession No. X14768), MCP-2 (e.g. polypeptides encoded by Genbank Accession No. Y16645), MCP-3 (e.g. polypeptides encoded by Genbank Accession No. X72308, S71251), MCP-4 (e.g. polypeptides encoded by Genbank Accession No. X98306), MCP-5 (e.g. polypeptides encoded by Genbank Accession No. U50712), MIP (macrophage inflammatory protein) (e.g. polypeptides encoded by Genbank Accession No. U77180, U77035, U49513, M35590), MRP-2 (e.g. as described in Youn B S et al (1995) Journal of Immunology 155: 2661-7), RANTES SDF (e.g. polypeptides encoded by Genbank Accession No. M21121, M77747), TARC (e.g Genbank protein Accession No. Q92583).
  • In addition there are several other factors that are related to chemokines but that either have not been assigned yet to one of the two chemokine groups or that do not possess the classical features of either of the two chemokine groups (for example, ATAC (e.g. polypeptides encoded by Genbank Accession No. X86474), Ltn (e.g. polypeptides encoded by Genbank Accession No. U15607, U23772), SCM-1 (e.g. polypeptides encoded by Genbank Accession No. D63789, D637090, D43769). These have been referred to as C-type chemokines or gamma-chemokines.
  • Yet another group of chemokines has been identified that comprises neurotactin (e.g. polypeptides encoded by Genbank Accession No. AF010586, which is characterized by a CX(3)C cysteine signature motif. The existence of clearly defined subgroups of chemokines on the basis of structural and functional properties illustrates the importance of chemoattractant diversity in the regulation of leukocyte movement through the body.
  • The biological activities of chemokines are mediated by specific receptors and also by receptors with overlapping ligand specificities that bind several of these proteins which always belong either to the C-C-chemokines or the group of C-X-C-chemokines. Chemokine receptors belong to the large group of G-protein-coupled seven transmembrane domain receptors which contain seven hydrophobic alpha-helical segments that transverse the membrane. These receptors form a structurally related group within the superfamily of G-protein-coupled receptors which mediate signalling via heterotrimeric G-proteins.
  • The receptors that bind C-X-C chemokines are designated CXCR followed by a number (e.g., CXCR-1 (e.g. polypeptides encoded by Genbank Accession No. L19591), CXCR-2 (e.g. polypeptides encoded by Genbank Accession No. M94582), CXCR-3 (e.g. polypeptides encoded by Genbank Accession No. X95876), CXCR-4 (e.g. polypeptides encoded by Genbank Accession No. D87747, AF025375) while those binding C-C chemokines are designated CCR followed by a number (e.g., CCR-1 (e.g. polypeptides encoded by Genbank Accession No.L09230, U29678), CCR-2 (e.g. polypeptides encoded by Genbank Accession No. U29677, U95626), CCR-3 (e.g. polypeptides encoded by Genbank Accession No. U51241), CCR-4 (e.g. polypeptides encoded by Genbank Accession No. X90862, X85740), CCR-5 (e.g. polypeptides encoded by Genbank Accession No. U54994, U83327), CCR-6 (e.g. polypeptides encoded by Genbank Accession No. U95626), CCR-7 (e.g. polypeptides encoded by Genbank Accession No. L31581), CCR-8 (e.g. polypeptides encoded by Genbank Accession No. Z98206, U45983). Viral chemokine receptor homologues include ECRF-3, EBI-1 (EBV-induced gene-1), and US28.
  • It is now assumed that the combinatorial effects of multiple chemokines and other mediators are responsible for the cellular composition at inflammatory sites. In addition, many chemokines also directly activate cells. Some of them activate granulocytes and/or monocytes and cause respiratory bursts, degranulation, and the release of lysosomal enzymes. Others prime immune cells to respond to sub-optimal amounts of other inflammatory mediators. Yet others have been shown to be potent histamine releasing factors for basophils. It has been proposed that erythrocytes through their promiscuous chemokine receptor play an important role in regulating the chemokine network. Chemokines bound to the erythrocyte receptor are known to be inaccessible to their normal target cells. This appears to provide a sink for superfluous chemokines and may serve to limit the systemic effects of these mediators without disrupting localized processes taking place at the site of inflammation.
  • Certain C-C chemokines exhibit biological activities other than mere chemotaxis. Some chemokines have been shown to be capable of inducing the proliferation and activation of killer cells known as CHAK (C-C-chemokine-activated killer), which are similar to cells activated by IL2.
  • Another particularly useful cytokine according to the invention is flt-3 ligand (e.g., polypeptides encoded by Genbank Accession Nos. U04806, U04807, U03858, L23636, U29874, U29875, U44024). This cytokine binds to the flt-3 tyrosine kinase (e.g., polypeptides encoded by Genbank Accession Nos. Z26652, X59398). The human flt-3 ligand also stimulates the proliferation of cells expressing murine flt-3 receptors.
  • The effects of flt-3 ligand are synergized by coexpression of G-C SF, GM-C SF, M-CSF, IL3, PIXY-321, and SCF. In combination with SCF and IL3 flt-3 ligand can cause expansion of cells with the marker spectrum CD34 (+)CD38 (−). Alone flt-3 ligand supports the survival of precursor cell types in the lineage of blood-forming cells such as CFU-GM, CFU-GEMM, and the very primitive high proliferative potential colony-forming cells. flt-3 ligand only has marginal effects on erythroid and megakaryocyte progenitor cells.
  • In the mouse, flt-3 ligand potently enhances growth of various types of progenitor/precursor cells in synergy with G-CSF, GM-CSF, M-CSF, IL3, IL6, IL7, IL11, IL12 and SCF. flt-3 ligand supports growth of LTC-IC (long-term culture-initiating cells). The ability of flt-3 ligand to promote the survival of hematopoietic progenitor cells is abrogated by TGF-beta and counteracted by TNF-alpha.
  • A study of the expression of functional flt-3 receptor and the responses to the ligand in AML (acute myeloid leukemia) and ALL (acute lymphoblastic leukemia) shows a considerable heterogeneity. BCP-ALL in particular fails to proliferate in the presence of flt-3 ligand despite strong expression of surface flt-3 receptor.
  • It has been shown that in patients with aplastic anemia and in cancer patients with chemotherapy-induced transient suppression of hematopoiesis, serum levels of flt-3 ligand fluctuate in an inverse relationship to the degree of bone marrow failure. flt-3 ligand levels in serum inversely correlate with the colony forming ability in vitro of bone marrow precursors from patients with aplastic anemia. flt-3 ligand treatment of mice challenged with syngeneic fibrosarcoma cells has been shown to result in complete tumor regression and in decreased tumor growth rates.
  • Antitumor cytokines are especially useful in the methods and compositions of the invention. According to the invention, an “antitumor cytokine” is a cytokine that can limit the growth or metastasis of tumor cells in vitro or in vivo, or can prolong the survival of a tumor-bearing animal, when either admixed with the cells or administered to the animal. The cytokine can be formulated as a solution in a biologically compatible buffer, e.g. PBS, and admixed with tumor cells in vitro. The concentration of cytokine may be from about the picomolar range to about the micromolar range. An antitumor cytokine will, for example, reduce the growth rate of the cells, e.g. by at least 10% compared to buffer alone, or inhibit metastatic properties of the cells, as may be evidenced by, e.g., increased cell adhesiveness or decreased ability to invade an extracellular matrix substrate, such as an artificial basement membrane. Alternatively, an antitumor cytokine may inhibit the growth or metastasis of a tumor in vivo, or may prolong the survival of a tumor-bearing animal. To evaluate the in vivo antitumor effects of a cytokine, the cytokine may be formulated in a pharmaceutically acceptable carrier and administered, e.g., by intravenous, intratumoral, or intraperitoneal injection. The cytokine may also be administered in association with cells, such as tumor cells that express or are coated with the cytokine.
  • Assays for Bioactivity
  • According to the invention, it is preferred that a cytokine be “bioactive”, “highly bioactive”, “extremely bioactive”, “natively bioactive”, or “suprabioactive”. Different levels of bioactivity relate to the ability to induce a change in a leukocyte (other than mere occupancy of the leukocyte's receptors for the cytokine). According to the invention, all naturally occuring cytokines are natively bioactive. Many types of assay can demonstrate the bioactivity of a non-naturally occurring cytokine. For example, a cytokine may be shown to induce survival and/or proliferation of a particular cell type. As another example, a cytokine may change the concentration of an intracellular second messenger, such as cAMP, arachidonic acid, calcium ions, or inositol triphosphate. The following are examples of assays for bioactivity:
  • Assay 1
  • Each well of one or more 60-well Lux microtiter trays is loaded with 200 FDC-P1 cells in 10 ul Dulbecco's modified Eagle's medium with a final concentration of 10% newborn calf serum. Cytokine in a concentration in at most the micromolar range is added to each well in a volume of 5 ul. The tray is incubated for 48 h at 37° C. in 10% CO2. Viable cell counts are performed. The average number of viable cells/well is counted. This assay is useful, for example, for identifying bioactivity mediated through a murine GM-CSF receptor.
  • Assay 2
  • Cytokine sample and a recombinant standard identical to a naturally occurring cytokine are each diluted serially in complete RPM1-10 in 96-well flat-bottom microtiter plates. Each dilution is plated in triplicate. CT.4S cells in active log-phase growth are collected, washed at least twice in complete RPM1-10, and resuspended in complete RPM1-10 at 1×105 cells/ml. 50 ul of the cell suspension is added to each well of the plate, which is then incubated for 24 h at 37° C. in 5% CO2 Tritiated thymidine is added to each well and the plate is incubated for an additional 24 h. The cells are then harvested and tritium incorporation is measured by liquid scintillation counting. This assay is useful, for example, for identifying bioactivity mediated through an IL-4 receptor.
  • Assay 3 (Colony Formation Assay)
  • Agar (4% w/v) is melted in sterile water by boiling 3 min. The agar is then cooled to 42° C. and added to 42° C. RPM1-15 to a final concentration of 0.4%. The solution is maintained at 42° C. Femurs are removed from young mice using sterile technique. Marrow is collected by flushing the opened ends of the bones with sterile Hank's Balanced Salt Solution (HBSS) using a syringe equipped with a 23G needle. Marrow is placed in a 15 ml tissue culture tube and vortexed into a cell suspension. Bone fragments are allowed to settle for 5 min, and the supernatant suspension is removed. The suspension is adjusted to 7.5×106 nucleated cells/ml and diluted 1:100 by adding the 42° C. RPMI with 0.4% agar. 2-fold serial dilutions of cytokine are added to 35 mm tissue culture dishes in a volume<=0.2 ml. Control dishes have no cytokine added. 1 ml warm cell suspension is added to each dish and the agar is allowed to set at room temperature. The cultures are incubated for 5-7 days at 37° C. in 5% CO2. Colony formation is then evaluated by microscopy. The average number of colonies of a given type (or aggregate number of colonies of given different types) on the cytokine plates and the average number on the control plates is counted. This assay is useful, for example, for identifying bioactivity mediated through CSF receptors.
  • Assay 4
  • Cytokine is diluted serially in RPMI 1640/25 mM HEPES/1% BSA. 25 ul of each dilution is plated in triplicate in a multiwell chemotaxis chamber bottom. Wells containing medium alone serve as negative controls and wells containing chemotaxis-inducing naturally occurring cytokine serve as positive controls. A polycarbonate membrane is placed over the chamber bottom and the chamber is assembled. 50 ul of peripheral blood mononuclear cells at 1.5×106 cells/ml in the RPMI/HEPES/BSA is added to each of the upper wells of the chamber. The chamber is incubated for 90 min at 37° C. in 5% CO2. The membrane is removed, washed, and stained. Migrated cells in 3-5 random fields of each well are counted by microscopy.
  • Assay 5
  • Naturally-occurring cytokine reference standard is diluted to 2 ng/ml in a 17×100 mm tube using supplemented medium. 3 further 5-fold serial dilutions are also prepared. Serial dilutions of cytokine are prepared in 17×100 mm tubes from 2 ng/ml to 20 pg/ml. 50 ul of PHA-activated human lymphoblasts 4×105 cells/ml in supplemental medium is added to each well of a 96-well flat-bottom microtiter plate. 50 ul of each dilution of reference standard or cytokine is added to triplicate wells. Negative control wells receive 50 ul of supplemented media alone. The plate is incubated for 48 h at 37° C. in 5% CO2 and the cells are labeled with tritiated thymidine. Incorporation is measured by liquid scintillation counting. This assay is useful, for example, for identifying bioactivity mediated through an IL-12 receptor.
  • Assay 6
  • In another assay for bioactivity, an immunocompetent animal is vaccinated with on the order of 104-108 irradiated cytokine-transduced or cytokine-coated tumor cells, and challenged with on the order of 104-108 live wild-type tumor cells (in any temporal sequence). Readouts of the assay are survival, tumor onset, or number of metastases.
  • Further examples of cytokine assays can be found, e.g., in: Callard R E et al Assay for human B cell growth and differentiation factors. in: Clemens M J et al (eds) Lymphokines and Interferons. A practical Approach, pp. 345-64, IRL Press, Oxford 1987; Coligan J E et al Current protocols in immunology. Grene and Wiley-Interscience, New York 1991); Dotsika E N Assays for mediators affecting cellular immune functions. Current Opinion in Immunology 2: 932-5 (1989); Feldmann M et al Cytokine assays: role in evaluation of the pathogenesis of autoimmunity. Immunological Reviews 119: 105-123 (1991); Guiguet M et al Misinterpretation of the biological activity of cytokine-containing preparations attributable to unrecognized interacting components. Analytical Biochemistry 247(2): 441-442 (1997); Hamblin A S & O'Garra A Assays for interleukins and other related factors. In: Lymphocytes, a practical approach, Klaus G G B (edt), pp. 209-28, IRL Press, Oxford, (1987); Laska E M & Meisner M J Statistical methods and applications of bioassay. Annu. Rev. Pharmacol. Toxicol. 27: 385-97 (1987); Mosman T R & Fong T A T Specific assays for cytokine production by T cells Journal of Immunological Methods 116: 151-8 (1989); Newton R C & Uhl J Assays relevant to the detection and quantitation of cytokines and their inhibitors. Modem Methods in Pharmacol. 5: 83-99 (1989); Thorpe R et al Detection and measurement of cytokines. Blood Rev. 6: 133-48 (1992); van Zoelen E J The use of biological assays for detection of polypeptide growth factors. Progress in Growth Factor Research 2: 131-52 (1990); Winstanley F P Cytokine bioassay. In: Gallagher G et al (eds) Tumor Immunobiology, A practical Approach. Oxford University Press, pp. 179-303 (1993); Wadha M et al Quantitative biological assays for individual cytokines. In: Balkwill F R (edt) Cytokines, A practical approach. Oxford University press, pp. 309-330 (1991)
  • According to the invention, if a non-naturally occurring cytokine gives a readout in a bioactivity assay that is at least 10% but not more than 29% (to the nearest 1%) of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “bioactive”. According to the invention, if a non-naturally occurring cytokine gives a readout in a bioactivity assay that is at least 30% but not more than 49% (to the nearest 1%) of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “highly bioactive”. According to the invention, if a non-naturally occurring cytokine gives a readout in a bioactivity assay that is at least 50% but not more than 69% (to the nearest 1%) of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “extremely bioactive”. According to the invention, if a non-naturally occurring cytokine gives a readout in a bioactivity assay that is at least 70% but not more than 100% (to the nearest 1%) of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “natively bioactive”. According to the invention, if a non-naturally occurring cytokine gives a readout in a bioactivity assay that is greater than 100% of the readout yielded by an equimolar amount of a naturally occurring cytokine (the latter giving a positive result in the assay), then the non-naturally occurring cytokine is “suprabioactive”.
  • Ligands for CD40 Useful According to the Invention
  • Nucleotide sequences encoding the CD40 proteins of various species are provided by, e.g. Genbank Accession Nos. Y10507, M83312, and U57745. Human CD40 is a transmembrane glycoprotein with a length of 277 amino acids (48 kDa). CD40 is a phosphoprotein and can be expressed as a homodimer. A soluble form of CD40 (28 kDa) has also been described. CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T-cells and monocytes, follicular dendritic cells, thymic epithelial cells, and various carcinoma cell lines. It is expressed on most mature B-cell malignancies and on some early B-cell acute lymphocytic leukemias. CD40 has been demonstrated on the majority of myeloma cell lines and myeloma cells from patients with plasma cell dyscrasia.
  • Induction of CD40 mRNA and enhancement of cell surface protein expression in primary human monocytes is observed after treatment with GM-CSF, IL3, or IFN-gamma. The human CD40 gene maps to chromosome 20.
  • CD40 has been proposed to play a role in the development of memory cells. It also plays a role in cell activation, functioning as a competence factor and progression factor. Crosslinking of the CD40 antigen (in combination with cytokines such as IL4 and IL5) leads to B-cell proliferation and induces immunoglobulin class switching from IgM to the synthesis of IgG, IgA, and IgE in the absence of activated T-cells. CD40 is one of the obligatory signals required for commitment of naive B-cells to IgA secretion; the mechanism of IgA induction requires the cooperation of IL10 and TGF-beta. Soluble CD40 inhibits T-cell-dependent B-cell proliferation.
  • Monoclonal antibodies against CD40 mediate a variety of effects on B-lymphocytes, including induction of intercellular adhesion (via CD11a/CD18 (LFA-1)), short- and long-term proliferation, differentiation and enhanced tyrosine phosphorylation of proteins. Germinal center centrocytes are prevented from undergoing cell death by apoptosis by activation through CD40 and antigen receptors.
  • In human resting B-cells expression of CD40 is induced by IL4. Treatment of human B-cells with IL6 leads to the phosphorylation of the intracellular CD40 domain. CD40 does not, however, function as a receptor for IL6. In activated human B-cells the synthesis of IL6 is induced by treatment of the cells with monoclonal antibodies directed against CD40, suggesting that CD40 participates in signal transduction mechanisms dependent on IL6.
  • Some limited sequence homologies have been found with receptors for Nerve Growth Factor, TNF-alpha and CD27 and it has been assumed that CD40 may be involved also in modulating the biological activity of these and other cytokines.
  • CD40 has biological functions also in non-immune cells although these are still largely unknown. CD40 ligation has been shown to induce cell death by apotosis in transformed cells of mesenchymai and epithelial origin. In part these processes are mediated through the death domain present in the cytoplasmic domain of CD40.
  • A particularly useful ligand for CD40 is CD154. CD154 (“CD40 ligand”; human protein 29.3 kDa, 261 amino acids) is a member of the TNF family of proteins. The human protein shows 82.8% and 77.4% identity at the cDNA and protein level, respectively, with a similar protein isolated from murine EL4 thymoma cells. Both proteins are the ligands for the CD40 cell surface antigen expressed on resting B-cells. The human gene encoding CD154 maps to chromosome Xq26.3-q27. Nucleotide sequences encoding the native CD40 ligands of various species are provided by, e.g., Genbank Accession Nos. X67878, X96710, X68550, X65453, Z48469, and L07414. Amino acid sequences of the CD154 molecules of various species are provided, e.g., by Entrez protein database Accession Nos. 1705713, 231718, 560693, 3047129, 116000, 1518170, 38412, 109639, 1083014, 38484, and 37270.
  • CD154 is naturally synthesized as a transmembrane polypeptide. Nevertheless, a biologically active soluble fragment of human CD154 has been described (Pietravalle et al, 1996, J Biol Chem 271:5965-5967.) Mazzei et al (1995, J Biol Chem 270:7025-7028) identified a biologically active soluble fragment of CD154 as a homotrimer of polypeptides consisting of amino acids Glu 108 through Leu 261 of intact transmembrane CD154. Graf et al (1995, Eur J Immunol 25:1749) describe another active fragment consisting of the C-terminal fragment produced by proteolyttic cleavage at Met 113. Aruffo et al disclose soluble forms of CD154 and their use to stimulate B cells in vitro in U.S. Pat. No. 5,540,926. In the present invention, particularly useful ligands for CD40 include polypeptides that comprise a sequence as set forth in SEQ ID NO. 2 of the '926 patent, from amino acid residues 47 to 261. These residues are comprised by the extracellular domain of human CD154.
  • Another particularly useful type of ligand for CD40 is an antibody to CD40. Examples of such antibodies include the monoclonal antibodies designated product numbers MCA1143 and MCA1590 of Harlan Bioproducts for Science (Indianapolis, Ind.); monoclonal antibodies designated catalog numbers P61640F (produced by clone 14G7), P42374M (produced by clone MAB89), P61046M (produced by clone BL-C4), and P54486M (produced by clone B-B20) of Biodesign International (Kennebunk, Me.); monoclonal antibody designated catalog number 05-422 (produced by clone 626.1) of Upstate Biotechnology (Lake Placid, N.Y.); monoclonal antibody designated catalog number 3601 (produced by clone S2C6) of Mabtech (Nacka, Sweden); monoclonal antibodies designated catalog numbers RDI-CBL486 (produced by clone BB20), RDI-M1691clb (produced by clone CLB-14G7), RDI-mCD40-323 (produced by clone 3/23) of Research Diagnostics (Flanders, N.J.); monoclonal antibodies described in Schwabe et al, 1997, Hybridoma 16:217-226; monoclonal antibodies described in Bjorck et al, 1994, Immunology 83:430-437; monoclonal antibody G28-5 described by Ledbetter et al, 1994, Circ Shock 44:67-72; and monoclonal antibodies described in Buske et al, 1997, Exp Hematol 25:329-337.
  • Opsonins Useful According to the Invention
  • As defined hereinabove, “opsonin” refers to naturally occurring and non-naturally occurring molecules which bind to both antigens and antigen presenting cells (APCs), such as, for example, phagocytic leukocytes (including monocytes and macrophages), dendritic cells (for example, Langerhans cells of the skin), B lymphocytes and, in humans, endothelial cells, or molecules which can be processed such that at least one product of the processing step or steps can bind to both antigens and antigen presenting cells (APCs), such as, for example, phagocytic leukocytes, dendritic cells, B lymphocytes, and, in humans, endothelial cells.
  • Without being bound to any one mechanism of action, it is believed that opsonin-enhanced cells provide a beneficial effect according to the invention because the opsonin portion acts as a link or coupling agent between the antigen and the APC to allow more efficient binding, engulfment, and internalization of the antigen. In addition, the opsonin itself can be internalized with the antigen. “Internalization” refers to the cellular uptake of a molecule such that it is brought into the cytoplasm or a compartment within the cytoplasm of the cell. Phagocytosis is a process by which a molecule is internalized by a cell.
  • Preferred opsonins are non-rodent opsonins, e.g., primate, e.g., human, opsonins. Opsonins useful according to the invention bind to receptors on APCs (e.g., phagocytic leukocytes, e.g., macrophages and other cells of the phagocytic system) such as receptors on cells which play a role in innate immunity, as described herein.
  • Some sets of opsonins can be regarded as structurally and functionally similar. For example, one family comprises fragments of complement components C3 and C4. These two components are highly structurally homologous, and each possesses an intramolecular thiolester bond that is broken when a peptide (C3a or C4a respectively) is proteolytically cleaved from the native molecule. Disruption of the thiolester makes available a chemical structure that can form an ester linkage with an antigen. The moiety of C3 on which this ester bond resides, i.e. the non-C3a moiety, is designated C3b, and C4b is the analogous product of C4 cleavage. C3b can be further proteolysed by proteins such as factor I to yield fragments such as C3bi and C3d, which also remain linked to the antigen via the ester bond.
  • There are four structurally unique proteins that are known to function as high affinity receptors for biologically active, membrane-bound fragments of C3 and/or C4. CR1 is the major receptor for the C3b fragment of C3 and C4b fragment of C4. It is expressed on monocytes and monocyte-derived APCs, among other cell types. CR2 is the major receptor for the fragment of C3 known as C3d, and is expressed on, e.g., mature B lymphocytes, but not on cells of monocytic lineage. The major role of CR2 on B lymphocytes is believed to be direct costimulation of B cells in concert with their cognate antigens.
  • CR3 is expressed primarily by neutrophils and monocytes and is also expressed on FDC, Kupffer cells, and NK cells. CR3 is a C3 fragment receptor with a primary specificity for C3bi. CR3 has been proposed as an important organizer of cytoskeletal events necessary for adhesive interactions and membrane reorganization during processes such as phagocytosis.
  • CR4 is a member of the beta2 integrin family, and its alpha chain is structurally similar to the alpha chain of CR3 and LFA-1. Its primary physiologic ligands are believed to be C3d and C3d,g;, however, its biologic activities are less well understood than CR3.
  • Another example of a family of innate opsonins is the collectins, a group of collagenous C-type lectins that comprises complement component C1q, mannose binding protein, surfactant proteins A and D, and conglutinin. Each molecule comprises a lectin domain that can bind to an antigen, and a collagenous domain that can bind to receptors on phagocytic mononuclear cells, including receptors that are wholly or partially identical to the C1q receptor (Nepomuceno et al, Immunity 6:11'9-29; Tenner et al, Immunity 3:485-93; Guan et al, J Immunol 152:4005-16; Geertsma et al, Am J Physiol 267:L578-84; Miyamura et al, Biochem J 300:237-42; Malhotra et al, J Exp Med 172:955-9; Malhotra et al, Biochem J 293:15-19). Most known collectins comprise multiple polypeptide chains, in some cases homomeric and in others heteromeric, that are assembled post-translationally, in part by covalent cross-linkage of hydroxyproline and hydroxylysine residues. Collectins are demonstrated to be opsonins in, for example, Pikaar et al, J Infect Dis 172:481-9; Alvarez-Dominguez et al, Infection & Immunity 61:3664-72; Kuhlman et al, J Exp Med 169:1733-45; and Geertsma et al, op cit.
  • Among the other innate opsonins useful according to the invention are C-reactive protein (CRP), alpha-2 macroglobulin, and fibronectin. CRP, a member of the pentraxin family of molecules, binds to receptors on cells of monocytic lineage and has been shown to be an opsonin (Tebo and Mortenson, J Immunol 144:231-8; Holzer et al, J Immunol 133:1424-30). Alpha-2 macroglobulin, like C3 and C4, comprises an internal thiolester bond that can be disrupted when the molecule is proteolysed. Such disruption allows covalent binding of the molecule to an antigen, and binding of alpha-2 macroglobulin to an APC can promote uptake of the conjugate. Fibronectin binds to the alpha 5 beta 1 integrin and can also bind to various antigens, allowing it to function as an opsonin (Cosio, J Lab Clin Med 103:613-9; Czop and Austen, J Immunol 129:2678-81).
  • Immunoglobulins (antibodies) can function as opsonins by binding antigens via their variable regions and APCs via their constant regions. Typically, an immunoglobulin comprises two heavy chains which are covalently bound to each other and each of which is bound to one light chain. These heterotetramers can further assemble into higher-order structures, such as the pentamers of IgM. Both heavy and light chain variable regions can contribute to the structure of the antigen binding site, whereas the APC binding site is located on the heavy chain constant region. Recombinant single-chain antibodies have also been described. APC receptors for immunoglobulins include Fc alpha, Fc gamma, Fc epsilon, and Fc mu receptors for IgA, IgG, IgE, and IgM, respectively.
  • Opsonins that are naturally expressed by multicellular eukaryotic organisms are secreted. The latter characteristic distinguishes opsonins from adhesion molecules. A non-naturally occurring molecule containing a naturally occurring APC-binding moiety shall be considered an opsonin if it contains a moiety through which it can be stably bound or attached to a cell such that the APC-binding moiety is located in the extracellular space, whether or not the molecule contains an antigen-binding moiety of a naturally occurring antigen. Moieties through which molecules can be stably bound to a cell include crosslinking moieties, transmembrane sequences, and lipid moieties. The preparation of proteins containing these sequences or moieties is well-known to one of skill in the art.
  • An “APC binding moiety of an opsonin” is a sequence or domain of an opsonin which when included in a chimeric molecule permits binding of the chimeric molecule to a receptor that is physiologically expressed on an APC with an affinity at least in the nanomolar range.
  • There are a number of examples of opsonin fragments that comprise APC binding moieties. Such a fragment may be any length so long as it retains an APC binding function; for example, it may be about 40 amino acids, 100 amino acids, 150 amino acids, 500 amino acids, 800 amino acids, or even as long as 3000 amino acids. For example, Las Holtet et al, 1994, FEBS Lett 344:242 describe a carboxy-terminal fragment of human α2m (val1299-ala1451) that binds with high affinity to the α2m receptor. Fragments comprising amino acids 1314-1451 of human α2m and the corresponding domain of rat α2m also bind to α2m receptors, albeit with 1-2% of the affinities of native α2m (Van Leuven et al, 1986, J Biol Chem 261:11369; Enghild et al, 1989, Biochemistry 28:1406; Salvesen et al, 1992, FEBS Lett 313:198; Sottrup-Jensen et al, 1986, FEBS Lett 205:20).
  • Becherer and Lambris, 1988, J Biol Chem 263:14586 describe fragments of C3b that bind to CR1, e.g., C3c, fragments of C3 generated by elastase treatment and comprising the N-terminal of the alpha′ chain of C3b, and a synthetic peptide comprising the 42 N-terminal amino acids of the C3b alpha′ chain. A binding sequence in C3 for CR3 has also been described (Wright et al, 1987, PNAS 84:4235).
  • “Collagen stalks” of C1q, which are N-terminal fragments obtained by pepsin digestion, bind to the C1q receptor (Reid, 1981, Methods Enzymol 80:16; Malhotra et al, 1993, Biochem J 293:15). Malhotra et al, ibid., also provide evidence that an APC binding moiety of conglutinin is comprised by its 55 N-terminal amino acids. Ezekowitz (U.S. Pat. No. 5,270,199) offers a putative APC binding site in human mannose binding protein consisting of nucleotides 370-438 of FIG. 2 in the '199 patent. In addition, by homology with conglutinin, exon 1 disclosed in the '199 patent may comprise an APC binding moiety.
  • An APC binding moiety of IgG comprises the CH2 domain and the lower hinge region, including residues 234-237, as described by Canfield and Morrison, 1991, J Exp Med 173:1483-91; Lund et al, 1991, J Immunol 147:2657-62; and Sarmay et al, 1992, Mol Immunol, 29:633-9.
  • Examples of opsonins which can be used in the compositions and methods of the invention include fibronectin (e.g., Genbank accessions X02761, K00799, K02273, X82402, X00307, X00739), CRP (e.g., Genbank accessions X17496, M11880, M11881, M11882), complement components such as C1q (e.g., Genbank accessions X66295, M22531, X03084, X58861, and Swiss-Prot accessions P02747, P02745), complement fragments such as C3b and C3d (e.g., Genbank accessions K02782, K02765), mannose binding protein (e.g., Genbank accessions S42292, S42294, X15422), conglutinin (e.g., Genbank accession X71774), alpha-2-macroglobulin (e.g., Genbank accessions M93264, M11313), and surfactant proteins A (e.g., Genbank accessions M68519, S48768) and D (e.g., Genbank accessions L40156, X65018, S38981), immunoglobulins, and their homologues among species.
    TABLE 2
    Exemplary Opsonin, APC binding moiety/APC receptor
    pairs useful according to the invention.
    Exemplary APC
    Opsonin Binding Moiety Receptor
    α-2 Val(1299)-Ala(1451) of α-2m receptor,
    macroglobulin human α-2m CD91
    C3b 42 N-terminal amino CR1
    acids of the α′
    chain of human C3b
    C3bi C3bi CR2, CR3
    C3d C3d CR2, CR4
    Clq Collagen stalks (Reid, Collectin receptor
    1981, Methods (Nepomuceno et al.,
    Enzymol. 80: 16) 1997, Immunity 6:
    119), CD93
    Conglutinin 55 N-terminal amino Collectin receptor
    acids of bovine
    conglutinin
    MBP 1. Polypeptide encoded Collectin receptor,
    by nt 370-438 of CD35, CD14
    FIG. 2,
    U.S. Pat. No. 5,270,199
    2. Polypeptide encoded
    by Econ . . . I of FIG. 2,
    U.S. Pat. No. 5,270,199
    CRP CRP CRP receptor, FcγRI,
    FcγRIIa (CD32)
    Fibronectin Fibronectin α5bl integrin
    IgG CH2 domain plus lower FcγRI, FcγRII,
    hinge including amino FcγRIII
    acids 234-237, as
    described by
    Lund et al., 1991, J.
    Immunol. 147: 2657
    Surfactant Surfactant Protein A Collectin receptor,
    Protein A Surfactant Protein D CD 14
    Surfactant
    Protein D
  • Determination of Opsonicity According to the Invention
  • A given naturally occurring opsonin is considered useful according to the invention if it is determined to possess opsonicity according to one or more of the following assays, and if it is a secreted molecule.
  • Assay 1
  • In one assay of opsonicity, as described by O'Rear and Ross in Current Protocols in Immunology, 1994, John Wiley & Sons, pp. 13.4.5-9, SRBC bound via a physiologically occurring linkage to the candidate opsonin molecule are obtained. APCs from the species to which the candidate opsonin is native are suspended at 4×106/ml in ice-cold HBSS with 1% (w/v) Cohn fraction of BSA. If the candidate opsonin is a fragment of C3, the APCs are freshly drawn, uncultivated peripheral blood monocytes. SRBC linked to the candidate opsonin or control SRBC (identical to the former but not linked to the candidate opsonin) are suspended in the same solution at 2×108/ml. 100 ul of SRBC suspension and 100 ul of APC suspension are mixed in a 10×75 mm plastic tube. The tube is rotated at 40 rpm at 37° C. for 2-20 min. A small drop of the suspension is placed on a slide, covered with a coverslip, and allowed to stand for 5-10 min. Excess fluid can be removed by pressure on the coverslip, and the coverslip can be sealed to the slide, e.g. with clear nail polish. The slide is examined microscopically, and the percentage of APCs visibly adherent to 4 or more SRBCs is determined. If the percentage is 50% or greater when there are up to 4×104 candidate opsonin molecules/SRBC′, the candidate opsonin can be an opsonin.
  • Assay 2 (For Protease-Activated Candidate Opsonin)
  • Candidate opsonin or radiolabeled Candidate opsonin is treated with a 1.5-3 fold molar excess of protease (0.05 M triethanolamine-0.1 M NaCl, pH 8.0, room temperature overnight). In this assay, the protease can serve as the antigen or an excess of another antigen can be added. Prior to binding studies, the candidate opsonin-antigen complex is dialyzed against HBSS (4° C.).
  • Candidate opsonin-antigen complex binding to monocytes is measured by incubating labeled ligand at a concentration up to 1.0 M with (1.5-4.0)×106 monocytes in 200 ml volume on ice. Nonspecific binding of radiolabeled ligands is determined in the presence of a 100-fold molar excess labeled candidate opsonin-antigen complex. The unbound ligand is separated from the cells and cell-bound ligand by rapid vacuum filtration on glass fiber filters. Studies are performed on ice to avoid potential complications due to endocytosis. Binding constarts and the number of sites per cell are determined by analysis and by nonlinear curve fit. If candidate opsonin-antigen complex affinity for a monocyte binding site is in at least the nanomolar range, the candidate opsonin is an opsonin.
  • Assay 3
  • Part I
  • To directly evaluate whether candidate opsonin is bound to the surface of P. carinii, immunoelectron microscopy is performed. P. carinii are isolated from bronchoaveolar lavage (BAL) of moribund infected rats using TBS with 1 mM calcium to preserve surface-bound candidate opsonin. Isolated organisms are fixed in periodate-lysine-paraformaldehyde buffer and embedded in Lowacryl mounting medium (Ted Pella, Inc., Redding, Calif.). Ultrathin sections are obtained, blocked with normal goat serum (2%) for 1 h, and incubated with either rabbit anti-candidate opsonin or nonimmune rabbit IgG (25 mg/ml) overnight. After washing, the sections are subsequently incubated with goat and rabbit IgG conjugated to 15 nM colloidal gold (Amersham Corp., Arlington Heights, Ill.). The sections are washed again and examined on a transmission electron microscope (model 6400:JEOL USA, Inc., Peabody, Mass.).
  • Part II
  • The attachment of P. carinii to cultured alveolar macrophages in the presence or absence of antibody to the candidate opsonin or with the addition of purified candidate is quantified as follows. Adherence of P. carinii to alveolar macrophages is assayed by 51Cr-labeling the organisms. P. carinii are isolated from infected rats with TBS containing 1 mM calcium to prevent loss of surface-bound candidate opsonin. The organisms are radiolabeled by incubation for 8 h at 37° C. in 2 ml of DME containing 20% FCS and 200 mCi of 51Cr-sodium chromate (New England Nuclear). Normal alveolar macrophages are lavaged from healthy rats and plated in tissue culture plates (1×105) cells/well) which are been precoated with normal rat IgG (100 mg/ml×60 min) in order to ensure firm adherence of the macrophages. After 1 h, the macrophages are gently washed with HBSS to remove nonadherent cells. >95% of macrophages are adherent after this wash. 51Cr-P. carinii (1×106) containing surface-associated candidate opsonin are added to the macrophages and incubated at 37° C. for an additional hour. Subsequently, nonadherent P. carinii are removed by washing. The macrophage monolayers containing adherent P. carinii are solubilized in 1 N NaOH and quantified. Adherence of P. carinii is defined as: percentage of adherence=(A/A+B)×100, where A=51Cr-P. carinii associated with the monolayer, and B=unattached 51Cr-P. carinii. To assess the effect of candidate opsonin on the attachment of P. carinii to alveolar macrophage lung cells in culture, P. carinii adherence assays are conducted in the presence or absence of a polyclonal rabbit antibody generated against the candidate opsonin (100 mg/ml).
  • If candidate opsonin binding to P. carinii is apparent in Part I and if, in Part II, % adherence is diminished in the presence of anti-candidate opsonin with statistical significance of P<0.05, the candidate opsonin is an opsonin.
  • Assay 4
  • Association of bacteria with adherent monocytes is measured as follows. Endotoxin level in the modified PBS and in all buffers used is below 50 pg/ml as determined by the Limulus assay. 5×103 monocytes in modified PBS are allowed to adhere to the wells of a Terasaki plate for 2 h at 37° C. After nonadherent cells are removed by three washes with PBS, 5×104 FITC-labeled bacteria in 0.5 ml buffer with or without 10-50 micrograms/ml of candidate opsonin are added. A bacteria-to-monocyte ratio of 10:1 to 50:1 is used. After 30 min of incubation at 37° C. in the dark, the nonadherent bacteria are removed by five washes with warm PBS. Assays are performed in quadruplicate; in each well, the number of bacteria associated with 3 100 monocytes is counted under a flourescence microscope using ×400 magnification. Results are expressed as the number of bacteria associated with 100 monocytes. If this number with candidate opsonin can be at least twice that without candidate opsonin, the candidate opsonin is an opsonin.
  • Assay 5
  • Part I
  • About 1×107 to 6×107 bacteria per ml are incubated (20 min, 0° C.) with 10 mcg/ml of 125I-candidate opsonin in a total volume of 0.7 ml. of PBS aliquots, 100 ml, of the reaction mixtures are layered over 150 ml of an oil cushion (60% dibutyl phthalate, 40% dioctyl phthalate [Eastman Kodak Co., Rochester, N.Y.]), and the mixtures are centrifuged (10,000×g, 60 s, 4° C.). The tip of the tube, containing the cell pellet, is cut with a Mozart razor blade, and the radioactivity is counted.
  • Part II
  • APCs are plated in 96-well tissue culture plates (Costar, Cambridge, Mass.) at 2×105 cells per ml the evening before use. 2×106 bacteria per well (0.1 ml per well) are added to the culture plates with or without 100 mcg/ml of candidate opsonin. The plates are then centrifuged at 1,000×g for 7 min. After 15 min at 37° C. to allow the uptake of bacteria, free bacteria are removed by several washes with cold PBS. They are then incubated (45 min, 37° C.) in RPMI 1640 plus an amount of antibiotic that, when present in the culture for 45 min, kills all extracellular bacteria. The end of this incubation period is considered time zero. Monolayers are washed three times with Hanks' balanced saline solution, and the same volume of RPMI 1640 (R0) is added. The cells are lysed by using several cycles of freezing and thawing. The number (CFU) of viable bacteria per well is determined by quantitative plate counts on blood agar plates (Columbia blood agar; Becton Dickinson, San Jose, Calif.) after 24 h of incubation. Each result is given as the mean of three determinations.
  • If, in Part I, candidate opsonin-treated bacterial pellet has >75 KCPM and this incorporation can be inhibited by unlabeled candidate opsonin, and if in Part II the CFU with candidate opsonin is greater than without (P<0.05), the candidate opsonin can be an opsonin.
  • Assay 6
  • 200 μl of GHBSS (Hanks Balanced Salt Solution)+0.1% of gelatin containing 10 m mol CaCl2) containing 107 bacteria is prepared. The bacteria are then incubated at 4° C. with 20-100 μg/ml of candidate opsonin. Binding assays are done in the presence or absence of a competitive inhibitor. After incubation for 30 minutes, the bacteria are washed five times in a GHBSS+10 mmol CaCl2 at room temperature in a microfuge at 1,300 g for 3 minutes. Thereafter, a 1:1,000 dilution of rabbit anti-candidate opsonin antiserum is incubated with the bacteria for 1 h in PBS+5% FCS and 10 mmol CaCl2 and then the bacteria are washed three times in GHBSS+10 mmol CaCl2 plus 0.05% Tween 20. Binding of anti-serum to bacteria is detected by a 1:1,000 dilution of goat anti-rabbit IgG conjugated to rhodamine (Fisher Pharmaceuticals, Orangeburg, N.Y.). After incubation, the bacteria are washed five times in GHBSS+10 mmol CaCl2 plus 0.05% Tween 20, smeared onto glass slides and allowed to air dry. Thereafter bacteria are fixed with 100% ice cold methanol for 5 minutes. Negative controls included the absence of candidate opsonin and no first step antibody. Numerous fields of triplicate assays are examined by fluorescence microscopy.
  • Part II Association of Radiolabeled Bacteria with Cells.
  • 107 radiolabeled bacteria are resuspended in 200 μl of GHBSS+10 mmol CaCl2 and are incubated with or without candidate opsonin ranging from 2 μg/ml to 40 μg/ml at 4° C. for 30 min. The bacteria are then washed three times in GHBSS+10 mmol CaCl2 for 3 min at room temperature in a microfuge at 1,300 g, resuspended in 50 μl of GHBSS and added to a 1-ml suspension containing on the order of 106 APCs (GHBSS). The bacteria and APCs are gently rocked at 37° C. for 20 min and thereafter the unattached bacteria are removed by five washes using differential centrifugation at 82 g in a microfuge. Before the last wash, an aliquot from each sample is plated on a Labtek slide and cells are adhered for 10 min, fixed in methanol, stained with Giemsa, and scored by light microscopy. To score the cells plated on the Labtek slides, at least 400 cells are counted. The phagocytic index represented the number of attached or ingested particles per 100 PMNs. The pellet from above containing cells and radiolabeled bacteria is then lysed in 100 μl PBS+0.5% Triton X-100 and the radioactivity is measured in a scintillation counter. If, in Part I, specific binding of candidate opsonin to bacteria is evident, and in Part II the specific uptake of bacteria, in cpm, is more than three times greater with candidate opsonin than without, the candidate opsonin can be an opsonin.
  • Assay 7
  • Part I
  • To investigate binding to L donovani promastigotes cultures are seeded at 5×105 parasites ml. At regular time points up to 9 days, a fraction of parasites are counted, washed, and resuspended in 1% BSA, 0.5 mM Ca2+. 0.05% NaN3, Tris-buffered saline (TBS), (10 mM Tris-HCl, 0.15 M NaCl, pH 8.0) (diluent) to 2×105 ml−1. Fifty microliters of this suspension are then added to 200-μl microfuge tubes containing 70 μl 5 μg/ml radiolabled candidate opsonin (0.12 μCi/μg) in diluent without EDTA, which had been layered over 150 μl of a dinonyl phthalate/dibutyl phthalate (40:60 v/v) oil mixture. Parasites are incubated for 1 h and centrifuged through the oil layer, the cell pellet is cut off, and associated candidate is detected by gamma counting. Each assay is performed in triplicate. The concentration dependency of candidate binding to promastigotes is also measured as above, using an activity of 0.045 μCi/μg and a twofold dilution series from 60 to 0.015 μg/ml candidate.
  • Part II
  • APCs are plated out at 1×106 cells/well on glass coverslips in a 24-well tissue culture plate. Cells are incubated in RPMI 1640 (Life Technologies) supplemented with 10% PCS, 1 mM glutamine, 200 U/ml penicillin and 200 μg/ml streptomycin in a humidified incubator at 37° C. After 24 h, nonadherent cells are removed and remaining cells are used after 6 days. Promastigotes are incubated with or without candidate at 30 μg/ml in RPMI 1640 for 1 h and then washed three times before adding to the APC cultures at 106/well. Promastigotes are allowed to infect APCs for 1 h, then cells are washed, fixed with methanol, and Geimsa stained (BDH, Poole, Dorset, U.K.) before counting. The percentage of APCs infected and the number of parasites/100 macrophages is determined from quadruplicate cultures.
  • If in Part I the affinity of candidate opsonin for parasites is at least in the nanomolar range and in Part II the number of parasites taken up/100 APCs is, with candidate opsonin, at least twice that without candidate opsonin, the candidate opsonin can be an opsonin.
  • Assay 8
  • Part I
  • Portions (0.5 ml) of [35S] methionine-labeled culture medium containing 5 percent fetal calf serum and the candidate opsonin are incubated for 30 minutes at room temperature with 0.1 ml or 0.2 ml of a 10 percent suspension of a microorganism). The microorganisms tested may include, for example, Salmonella typhimurium, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Saccharomyces cerevisiae. Bound proteins are released by boiling in buffer containing 2 percent SDS and 0.1 M dithiothreitol and are analyzed on a 5 percent SDS gel.
  • Part II
  • Fixed bacteria (0.1 ml; 10 percent by volume; 1010 organisms per millileter), labeled with [3H]thymidine, are incubated with 0.1 ml of serum with or without depletion of the candidate opsonin. After being washed with PBS, the bacteria are incubated with on the order of 1×107 APCs in a final volume of 0.9 ml PBS containing divalent cations. At intervals 0.2 ml is removed to ice-cold PBS with N-ethylmaleimide (2 mM) to block further endocytosis, and the cells are washed (at about 100 g for 10 seconds)
  • If in Part I a band corresponding to the candidate opsonin is apparent, and if in Part II the CPM after 6-10 min of incubation is at least three times greater for undepleted samples with serum than with depleted serum, the candidate opsonin can be an opsonin.
  • In lieu of results form Parts I of assays 3, 5, 6, 7, 8, a candidate opsonin that satisfies Part II of an assay can be an opsonin if it can bind to the antigen of the assay with an affinity in at least the nanomolar range.
  • Assay 9
  • SRBC coated with at least 1.2×104 molecules/cell of a fragment of C3 are prepared as described by O'Rear and Ross in Current Protocols in Immunology, 1994, John Wiley & Sons, pp. 13.4.5-9. 250 ul of monocytes at 2×105 cells/ml of RPMI with 10% fetal calf serum are added to each well of an 8-well glass tissue culture plate and incubated at 37° C., 5% CO2 for 3 h. The monocytes are washed twice with HBSS, and 50 ul of the SRBC at 1.5×108/ml of DVBS2+ are added to each well. The plate is centrifuged at 50 g for 5 min and then incubated at 37° C., 5% CO2 for 3 h. The walls are washed twice with HBSS, fixed with 0.5% glutaraldehyde, and stained with Giemsa stain. If >40% of the monocytes form rosettes with at least 1 SRBC as determined by light microscopy, the candidate can be an opsonin.
  • Heat Shock Proteins Useful in the Invention
  • Heat shock proteins (HSPs) are associated in cells with a broad spectrum of peptides, polypeptides, denatured proteins and antigens with which they form complexes. Such HSP-peptide complexes have been described as being useful in vaccines against cancers and infectious diseases by Srivastava et al., “Heat shock protein-peptide complexes in cancer immunotherapy” in Current Opinion in Immunology (1994), 6:728-732; Srivastava, “Peptide-Binding Heat Shock Proteins in the Endoplasmic Reticulum” in Advances in Cancer Research (1993), 62:153-177. The HSP-peptide complexes appear to work as vaccines, because they may function as antigen carrying and presentation molecules. The development of vaccines using such antigens has been described by Baltz, “Vaccines in the treatment of Cancer” in Am. J. Health-Syst. Pharm. (1995), 52:2574-2585. The antigenicity of heat shock proteins appears to derive not from the heat shock protein itself, but from the associated peptides, see Udono et al., “Heat Shock Protein 70-associated Peptides Elicit Specific Cancer Immunity” in J. Exp. Med. (1993), 178:1391-1396; Srivastava et al., “Heat shock proteins transfer peptides during antigen processing and CTL priming” in Immunogenetics (1994), 39:93-98; Srivastava, “A Critical Contemplation on the Roles of Heat Shock Proteins in Transfer of Antigenic Peptides During Antigen Presentation” in Behring Inst. Mitt. (1994), 94:37-47. HSPs appear to be part of the process by which peptides are transported to the Major Histocompatibility Complex (MHC) molecules for surface presentation.
  • A number of different HSPs have been shown to exhibit immunogenicity, and are useful in the present invention, including, but not limited to: gp96, hsp90, hsp100, hsp60, hsp 25 and hsp70, see Udono et al., supra. and Udono et al., “Comparison of Tumor-Specific Immunogenicities of Stress-Induced Proteins gp96, hsp90, and hsp 70” in Journal of Immunology (1994), 5398-5403; gp96 and grp94, Li et al., “Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation” in The EMBO Journal, Vol. 12, No. 8 (1993), 3143-3151; and gp96, hsp90 and hsp70, Blachere et al., “Heat Shock Protein Vaccines Against Cancer” in Journal Of Immunotherapy (1993), 14:352-356.
  • Heat shock proteins may be purified for use in the present invention using a procedure employing DE52 ionexchange chromatography followed by affinity chromatography on ATP-agarose, see Welch et al., “Rapid Purification of Mammalian 70,000-Dalton Stress Proteins: Affinity of the Proteins for Nucleotides” in Molecular and Cellular Biology (June 1985), 1229-1237.
  • Adhesion Molecules Useful in the Invention
  • Adhesion molecules useful in the present invention include any cell-surface protein which is involved in bediating the recognition and adhesion of cell sto their substrate and to other cells. Cellular adhesion molecules can be divided into two primary classes: Ca2+ dependent (cadherins) and Ca2+ independent.
  • There are over a dozen different types of Ca2+ dependent adhesion molecules called cadherins. Most cadherins are single-pass transmembrane glycoproteins composed of about 700-750 amino acid residues. The large extracellular part of the molecule is usually folded into five domains, each containing about 100 amino acid residues. Four of these domains contain presumptive Ca2+ binding sites. Cadherins are often present in the cell membrane as dimers.
  • Cadherens useful in the present invention include, but are not limited to cadherin E, cadherin N, cadherin BR, cadherin P, cadherin R, cadherin M, cadherin VE, cadherin T&H, cadherin OB, cadherin K, cadherin 7, cadherin 8, cadherin KSP, cadherin LI, cadherin 18, fibroblast 1, cadherin, fibroblast 2, cadherin, fibroblast 3, cadherin 23, desmocollin 1, desmocollin 2, desmoglein 1, desmoglein 2, desmoglein 3, and protocadherin 1, 2, 3, 7, 8, and 9.
  • The remaining adhesion molecules are Ca2+ independent, and, like the cadherins, may be used as ligands of a cell surface protein on an APC in the present invention. General classes of adhesion molecules as well as specific adhesion molecules useful in the present invention are shown below in Table 3.
    TABLE 3
    Selectins
    L-selectin; E-selectin; P-selectin
    Integrins
    α1β1; α2β1; α3β1; α4β1; α5β1; α6β1; α7β1; α8β1; α9β1;
    ανβ1; αLβ2; αMβ2; αXβ2; αIIbβ3; ανβ3; α6β4; ανβ5; ανβ6;
    ανβ7; αIELβ7; α11
    Immunoglobulin
    Superfamily
    Neural Specific: Adhesion molecule on glia (AMOG);
    L1CAM; Myelin-associated glycoprotein (MAG); Myelin-
    oligodendrocyte glycoprotein (MOG); NCAM-1 (CD-56);
    NrCAM; OBCAM; P0protein; PMP-22protein; Neurofascin;
    NgCAM
    Systemic IgCAMS: ALCAM; Basigin (CD147); BL-CAM
    (CD22); CD44; ICAM-1 (CD54); ICAM-3 (CD50); Lymphocyte
    function antigen-2 (LFA-2); LFA-3 (CD58; MHC molecules;
    MAdCAM-1; PECAM (CD31); T-cell receptor; VACM-1
    Other Adhesion
    Molecules
    Agrin; CD34; GlyCAM-1; Oligodendrocyte-myelin
    glycoprotein (OMGP)
  • Defensins Useful in the Invention
  • In one embodiment, the portion of the multifunctional molecule which is a ligand of a cell surface protein of an APC is a defensin. Defensins are a large family of broad-spectrum antimicrobial peptides, identified originally in leukocytes of rabbits and humans. Defensins, cationic, polar peptides (30-35 aa, 3-4 kDa), are distinguished by a conserved tri-disulfide and largely beta sheet structure. When expressed at the cell surface, defensins have been hypothesized to function as a biocheical barrier against microbial invection by inhibiting colonization of the epithelium by a wide range of pathogenic microorganisms. Defensins useful in the present invention include, but are not limited to human alpha defensins 1-6, human neutrophil peptides 1-4, human beta defensin 1 and 2, and rat beta defeinsin 1 and 2.
  • Counter-Receptors of T Cell Co-Stimulatory Molecules of the Invention
  • In one embodiment of the invention the portion of the multifunctional molecule which is a ligand of a cell surface protein of an APC is a counter-receptor of a T cell co-stimulatory molecule. Costimulation is defined as a signaling pathway that does more than simply augment antigen receptor-proximal activation events, but that intersects with antigen-specific signals synergistically to allow lymphocyte activation. Accordingly, a counter-receptor of a co-stimulatory molecule, useful in the present invention includes, but is not limited to a receptor for one or more of B7-1, B7-2, ICOS:B7h, PD-1:PD-L1/PD-L2, CD48, CD40 ligand, and OX40. Counter-receptors useful in the present invention include, but are not limited to CD28, CTLA-4, ICOS, PD-1, members of the TNF receptor family, CD40, the major B cell costimulatory molecule, as well as OX-40, 4-1BB, CD30, and CD27.
  • Peptide Linkers
  • In one embodiment, the multifunctional molecule is a fusion polypeptide which comprises one or more amino acids interposed between the first and second parts which bind to cells, e.g. a fusion polypeptide which comprises a first amino acid sequence which can bind to an antigen bearing target and a second amino acid sequence which can bind to a leukocyte, and which further comprises at least one amino acid interposed between the first and second parts. The interposed amino acids may comprise, e.g., a linker sequence intended to lessen steric hindrance or other undesirable interactions between the aforementioned first and second parts. For, example, one such type of sequence takes the form (GlyxSer)n, wherein n is an integer from between 1 and 15, and x is an integer betewen 1 and 10. Additional useful linkers include, but are not limited to (Arg-Ala-Arg-Asp-Pro-Arg-Val-Pro-Val-Ala-Thr)1-5 (Xu et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96: 151-156), (Gly-Ser), (Shao et al., 2000, Bioconjug. Chem. 11: 822-826), (Thr-Ser-Pro)n (Kroon et al., 2000, Eur. J. Biochem. 267: 6740-6752), (Gly-Gly-Gly), (Kluczyk et al., 2000, Peptides 21: 1411-1420), and (Glu-Lys)n (Klyczyk et al., 2000, supra), wherein n is 1 to 15 (each of the preceding references is also incorporated herein by reference). In another embodiment, no amino acids are interposed between the first and second parts.
  • Antigens Useful According to the Invention
  • 1. Viral Antigens
  • Examples of viral antigens include, but are not limited to, retroviral antigens such as retroviral antigens from the human immunodeficiency virus (HIV) antigens such as gene products of the gag, pol, and env genes, the Nef protein, reverse transcriptase, and other HIV components; hepatitis viral antigens such as the S. M, and L proteins of hepatitis B virus, the pre-S antigen of hepatitis B virus, and other hepatitis, e.g., hepatitis A, B. and C, viral components such as hepatitis C viral RNA; influenza viral antigens such as hemagglutinin and neuraminidase and other influenza viral components; measles viral antigens such as the measles virus fusion protein and other measles virus components; rubella viral antigens such as proteins E1 and E2 and other rubella virus components; rotaviral antigens such as VP7sc and other rotaviral components; cytomegaloviral antigens such as envelope glycoprotein B and other cytomegaloviral antigen components; respiratory syncytial viral antigens such as the RSV fusion protein, the M2 protein and other respiratory syncytial viral antigen components; herpes simplex viral antigens such as immediate early proteins, glycoprotein D, and other herpes simplex viral antigen components; varicella zoster viral antigens such as gpI, gpII, and other varicella zoster viral antigen components; Japanese encephalitis viral antigens such as proteins E, M-E, M-E-NS 1, NS 1, NS 1-NS2A, 80% E, and other Japanese encephalitis viral antigen components; rabies viral antigens such as rabies glycoprotein, rabies nucleoprotein and other rabies viral antigen components. See Fundamental Virology, Second Edition, e's. Fields, B. N. and Knipe, D. M. (Raven Press, New York, 1991) for additional examples of viral antigens.
  • 2. Bacterial Antigens
  • Bacterial antigens which can be used in the compositions and methods of the invention include, but are not limited to, pertussis bacterial antigens such as pertussis toxin, filamentous hemagglutinin, pertactin, FIM2, FIM3, adenylate cyclase and other pertussis bacterial antigen components; diptheria bacterial antigens such as diptheria toxin or toxoid and other diphtheria bacterial antigen components; tetanus bacterial antigens such as tetanus toxin or toxoid and other tetanus bacterial antigen components; streptococcal bacterial antigens such as M proteins and other streptococcal bacterial antigen components; grarn-negative bacilli bacterial antigens such as lipopolysaccharides and other gram-negative bacterial antigen components; Mycobacterium tuberculosis bacterial antigens such as mycolic acid, heat shock protein 65 (HSP65), the 30 kDa major secreted protein, antigen 85A and other mycobacterial antigen components; Helicobacter pylori bacterial antigen components; pneumococcal bacterial antigens such as pneumolysin, pneumococcal capsular polysaccharides and other pneumococcal bacterial antigen components; hemophilus influenza bacterial antigens such as capsular polysaccharides and other hemophilus influenza bacterial antigen components; anthrax bacterial antigens such as anthrax protective antigen and other anthrax bacterial antigen components; rickettsiae bacterial antigens such as romps and other rickettsiae bacterial antigen component. Also included with the bacterial antigens described herein are any other bacterial, mycobacterial, mycoplasmal, rickettsial, or chlamydial antigens.
  • 3. Fungal Antigens
  • Fungal antigens which can be used in the compositions and methods of the invention include, but are not limited to, candida fungal antigen components; histoplasma fungal antigens such as heat shock protein 60 (HSP60) and other histoplasma fungal antigen components; cryptococcal fungal antigens such as capsular polysaccharides and other cryptococcal fungal antigen components; coccidiodes fungal antigens such as spherule antigens and other coccidiodes fungal antigen components; and tinea fungal antigens such as trichophytin and other coccidiodes fungal antigen components.
  • 4. Parasite Antigens
  • Examples of protozoa and other parasitic antigens include, but are not limited to, plasmodium falciparum antigens such as merozoite surface antigens, sporozoite surface antigens, circumsporozoite antigens, gametocyte/gamete surface antigens, blood-stage antigen pf 1 55/RESA and other plasmodial antigen components; toxoplasma antigens such as SAG-1, p30 and other toxoplasma antigen components; schistosomae antigens such as glutathione-S-transferase, paramyosin, and other schistosomal antigen components; leishmania major and other leishmaniae antigens such as gp63, lipophosphoglycan and its associated protein and other leishmanial antigen components; and trypanosoma cruzi antigens such as the 75-77 kDa antigen, the 56 kDa antigen and other trypanosomal antigen components.
  • 5. Tumor Antigens.
  • Tumor antigens which can be used in the compositions and methods of the invention include, but are not limited to, telomerase components; multidrug resistance proteins such as P-glycoprotein; MAGE-1, alpha fetoprotein, carcinoembryonic antigen, mutant p53, immunoglobulins of B-cell derived malignancies, fusion polypeptides expressed from genes that have been juxtaposed by chromosomal translocations, human chorionic gonadotrpin, calcitonin, tyrosinase, papillomavirus antigens, gangliosides or other carbohydrate-containing components of melanoma or other tumor cells. It is contemplated by the invention that antigens from any type of tumor cell can be used in the compositions and methods described herein.
  • 6. Antigens Relating to Autoimmunity.
  • Antigens involved in autoimmune diseases, allergy, and graft rejection can be used in the compositions and methods of the invention. For example, an antigen involved in any one or more of the following autoimmune diseases or disorders can be used in the present invention: diabetes mellitus, arthritis (including rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, psoriatic arthritis), multiple sclerosis, myasthenia gravis, systemic lupus erythematosis, autoimmune thyroiditis, dermatitis (including atopic dermatitis and eczematous dermatitis), psoriasis, Sjogren's Syndrome, including keratoconjunctivitis sicca secondary to Sjogren's Syndrome, alopecia areata, allergic responses due to arthropod bite reactions, Crohn's disease, aphthous ulcer, iritis, conjunctivitis, keratoconjunctivitis, ulcerative colitis, asthma, allergic asthma, cutaneous lupus erythematosus, scleroderma, vaginitis, proctitis, drug eruptions, leprosy reversal reactions, erythema nodosum leprosum, autoimmune uveitis, allergic encephalomyelitis, acute necrotizing hemorrhagic encephalopathy, idiopathic bilateral progressive sensorineural hearing loss, aplastic anemia, pure red cell anemia, idiopathic thrombocytopenia, polychondritis, Wegener's granulomatosis, chronic active hepatitis, Stevens-Johnson syndrome, idiopathic sprue, lichen planus, Crohn's disease, Graves ophthalmopathy, sarcoidosis, primary biliary cirrhosis, uveitis posterior, and interstitial lung fibrosis. Examples of antigens involved in autoimmune disease include glutamic acid decarboxylase 65 (GAD 65), native DNA, myelin basic protein, myelin proteolipid protein, acetylcholine receptor components, thyroglobulin, and the thyroid stimulating hormone (TSH) reception. Examples of antigens involved in allergy include pollen antigens such as Japanese cedar pollen antigens, ragweed pollen antigens, rye grass pollen antigens, animal derived antigens such as dust mite antigens and feline antigens, histocompatiblity antigens, and penicillin and other therapeutic drugs. Examples of antigens involved in graft rejection include antigenic components of the graft to be transplanted into the graft recipient such as heart, lung, liver, pancreas, kidney, and neural graft components. An antigen can also be an altered peptide ligand useful in treating an autoimmune disease.
  • Examples of miscellaneous antigens which can be can be used in the compositions and methods of the invention include endogenous hormones such as luteinizing hormone, follicular stimulating hormone, testosterone, growth hormone, prolactin, and other hormones, drugs of addiction such as cocaine and heroin, and idiotypic fragments of antigen receptors such as Fab-containing portions of an anti-leptin receptor antibody.
  • Determination of Binding of a Multifunctional Molecule to a Antigen Bearing Target or APC
  • Multiple techniques are known to those of skill in the art for detecting protein-protein binding. That is, the binding of a multifunctional molecule of the invention to either or both of an antigen bearing target and an APC.
  • The association between the multifunctional molecule and an antigen bearing target and/or an APC may be measured for example by Fluorescent Resonance Energy Transfer (FRET), wherein one peptide (i.e., the multifunctional molecule) comprises a fluorescent label moiety, and the antigen bearing target or APC harbours a second such moiety, and where excitation at an appropriate wavelength may result in absorption of photons by one label, followed by FRET, and emission at a second wavelength characteristic of the second fluorophore, this emission being measured and corresponding to the amount of antigen bearing target or APC which is associated with the multifunctional molecule. Alternatively, this association may be measured in one of many other ways which are described more fully below.
  • A “fluorescent tag” or “fluorescent group” refers to either a fluorophore or a fluorescent protein or fluorescent fragment thereof, or refers to a fluorescent amino acid such as tryptophan which may be incorporated into a polypeptide. “Fluorescent protein” refers to any protein which fluoresces when excited with appropriate electromagnetic radiation. This includes proteins whose amino acid sequences are either natural or engineered.
  • It is additionally preferred that the fluorophores comprise fluorescein and tetramethylrhodamine or another suitable pair. In another preferred embodiment, the label comprises two different fluorescent proteins. It is preferred that fluorescent proteins comprise any protein selected from the group consisting of green fluorescent protein (GFP), blue fluorescent protein, red fluorescent protein and other engineered forms of GFP.
  • Preferably, the polypeptide comprises a cysteine amino acid through which the label is attached via a covalent bond. More preferably, the label may be attached via a primary amine group such as via a lysine residue. As will be apparent to a person skilled in the art, it is preferable to avoid using the same chemistry for both labelling and immobilising polypeptides of the invention. For example, if the polypeptide is immobilised via cysteine residues, the label is advantageously attached via lysine residues.
  • Preferably, the measuring is performed by fluorescent resonance energy transfer (FRET), fluorescence anisotropy or fluorescence correlation spectroscopy, or by measuring the binding of a fluorescent partner polypeptide to an immobilised polypeptide. Techniques for performing such measurements are well known to those of skill in the art.
  • It is preferred that the fluorescence emitting means comprise two different fluorophores, and particularly preferred that the fluorophores comprise fluorescein and tetramethylrhodamine or another suitable pair.
  • As used herein with regard to fluorescent labels for use in FRET, the term “appropriate combination” refers to a choice of reporter labels such that the emission wavelength spectrum of one (the “donor” moiety) is within the excitation wavelength spectrum of the other (the “acceptor” moiety).
  • Methods of detection without use of label are known in the art. These include detection using surface plasmon resonance to detect changes in the mass of, for example the multifunctional molecule, which would occur if binding of the partner polypeptide increased or decreased. Such measurements may be made for example using a BIACORE machine. In this embodiment, the multifunctional molecule is immobilized on a solid support prior to contacting the molecule with the antigen bearing moiety and/or APC.
  • In addition to the above methods, one technique for determing the binding of a multifunctional molecule of the invention to an antigen bearing moiety and/or and APC involves the use of antibodies specifically directed to the multifunctional molecule. Briefly, antigen bearing cells, for example, are incubated with the multifunctional molecule of the invention in RPMI 1640, or other suitable buffer, for 1-4 hours at 37° C. with shaking. The cells are then washed in PBS containing 2% FBS, or other cell culture serum. The antigen bearing cells are then incubated with, for example, an FITC labeled anti-multifunctional molecule antibody for 1 hour at 4° C. After additional washing in PBS, the cells are analyzed by flow cytometry, wherein the identification of labeled cells is indicative of the binding of the multifunctional molecule of the invention to the antigen bearing cell.
  • Preparation of a Cell Containing a Recombinant Nucleic Acid According to the Invention
  • In one embodiment of the present invention, a nucleic acid molecule encoding a multifunctional molecule of the present invention is introduced into a host cell capable of expressing the nucleic acid molecule so as to produce the multifunctional molecule. In one embodiment, the host cell is permitted to express the nucleic acid ex vivo. In an alternate embodiment, the host cell is transfected with the nucleic acid molecule encoding the multifunctional molecule, and then placed back into the host animal from which it was obtained, wherein the multifunctional polypeptide molecule is expressed in vivo in the host animal.
  • Host cells are transfected, as taught herein, via conventional methods well-known in the art. Suitable methods for transforming or transfecting host cells can be found in Sambrook et al. (Molecular Cloning: A Laboratory Manual, 2nd Edition, Cold Spring Harbor Laboratory press (1989)), and other laboratory manuals. Additional examples of methods of introducing nucleic acid molecules encoding multifunctional molecules are described below. The cells containing the introduced nucleic acid molecules encoding, for example, multifunctional molecule and/or an antigen, can themselves be administered to a subject (as the antigen) according to the methods of the invention, e.g., in a vaccine composition.
  • A. Introduction of Naked Nucleic Acid into Cells
  • 1. Transfection mediated by DEAE-dextran: Naked nucleic acid can be introduced into cells by forming a mixture of the nucleic acid and DEAE-dextran and incubating the mixture with the cells. A dimethylsulfoxide or chloroquine shock step can be added to increase the amount of nucleic acid uptake. DEAE-dextran transfection is only applicable to in vitro modification of cells and can be used to introduce nucleic acid transiently into cells but is not preferred for creating stably transfected cells. Thus, this method can be used for short term production of a gene product but is not a method of choice for long-term production of a gene product. Protocols for DEAE-dextran-mediated transfection can be found in Current Protocols in Molecular Biology, Ausubel, F. M. et al. (e's.) Greene Publishing Associates, (1989), Section 9.2 and in Molecular Cloning: A Laboratory Manual. 2nd Edition. Sambrook et al. Cold Spring Harbor Laboratory Press, (1989), Sections 16.41-16.46 or other standard laboratory manuals.
  • 2. Electroporation: Naked nucleic acid can also be introduced into cells by incubating the cells and the nucleic acid together in an appropriate buffer and subjecting the cells to a high-voltage electric pulse. The efficiency with which nucleic acid is introduced into cells by electroporation is influenced by the strength of the applied field, the length of the electric pulse, the temperature, the conformation and concentration of the nucleic acid and the ionic composition of the media. Electroporation can be used to stably (or transiently) transfect a wide variety of cell types and is only applicable to in vitro modification of cells. Protocols for electroporating cells can be found in Current Protocols in Molecular Biology, Ausubel, F. M. et al. (e's.) Greene Publishing Associates, (1989), Section 9.3 and in Molecular Cloning: A Laboratory Manual, 2nd Edition, Sambrook et al. Cold Spring Harbor Laboratory Press, (1989), Sections 16.54-16.55 or other standard laboratory manuals.
  • 3. Liposome-mediated transfection (“lipofection”): Naked nucleic acid can be introduced into cells by mixing the nucleic acid with a liposome suspension containing cationic lipids. The nucleic acid/liposome complex is then incubated with cells. Liposome mediated transfection can be used to stably (or transiently) transfect cells in culture in vitro. Protocols can be found in Current Protocols in Molecular Biology, Ausubel, F. M. et al. (e's.) Greene Publishing Associates, (1989), Section 9.4 and other standard laboratory manuals. Additionally, gene delivery in vivo has been accomplished using liposomes. See for example Nicolau et al. (1987) Meth. Enz. 149:157-176; Wang and Huang (1987) Proc. Natl. Acad. Sci. SA 84:7851-785S; Brigham et al. (1989) Am. J. Med. Sci. 298:278; and Gould-Fogerite et al. (1989) Gene 84:429-438.
  • 4. Direct Injection: Naked nucleic acid can be introduced into cells by directly injecting the nucleic acid into the cells. For an in vitro culture of cells, nucleic acid can be introduced by microinjection. Since each cell is microinjected individually, this approach is very labor intensive when modifying large numbers of cells. However, a situation wherein microinjection is a method of choice is in the production of transgenic animals (discussed in greater detail below). In this situation, the nucleic acid is stably introduced into a fertilized oocyte which is then allowed to develop into an animal. The resultant animal contains cells carrying the nucleic acid introduced into the oocyte. Direct injection has also been used to introduce naked nucleic acid into cells in vivo (see e.g., Acsadi et al. (1991) Nature 332: 815-818; Wolff et al. (1990) Science 247:1465-1468). A delivery apparatus (e.g., a “gene gun”) for injecting DNA into cells in vivo can be used. Such an apparatus is commercially available (e.g., from BioRad).
  • 5. Receptor-Mediated DNA Uptake: Naked nucleic acid can also be introduced into cells by complexing the nucleic acid to a cation, such as polylysine, which is coupled to a ligand for a cell-surface receptor (see for example Wu, G. and Wu, C. H. (1988) J. Biol. Chem 263:14621; Wilson et al. (1992) J. Biol. Chem. 267:963-967; and U.S. Pat. No. 5,166,320). Binding of the nucleic acid-ligand complex to the receptor facilitates uptake of the nucleic acid by receptor-mediated endocytosis. Receptors to which a nucleic acid-ligand complex have targeted include the transferrin receptor and the asialoglycoprotein receptor. A nucleic acid-ligand complex linked to adenovirus capsids which naturally disrupt endosomes, thereby releasing material into the cytoplasm can be used to avoid degradation of the complex by intracellular lysosomes (see for example Curiel et al. (1991) Proc. Natl. Acad. Sci. USA 88:8850; Cristiano et al. (1993) Proc. Natl. Acad. Sci USA 90:2122-2126). Receptor-mediated nucleic acid uptake can be used to introduce nucleic acid into cells either in vitro or in vivo and, additionally, has the added feature that nucleic acid can be selectively targeted to a particular cell type by use of a ligand which binds to a receptor selectively expressed on a target cell of interest.
  • Generally, when naked nucleic acid is introduced into cells in culture (e.g., by one of the transfection techniques described above) only a small fraction of cells (about 1 out of 105) typically integrate the transfected nucleic acid into their genomes (i.e., the nucleic acid is maintained in the cell episomally). Thus, in order to identify cells which have taken up exogenous nucleic acid, it is advantageous to transfect nucleic acid encoding a selectable marker into the cell along with the nucleic acid(s) of interest. Preferred selectable markers include those which confer resistance to drugs such as G418, hygromycin and methotrexate. Alternatively, a selectable marker maybe one which emits a detectable signal upon expression such as green fluorescen protein or blue fluorescent protein. Selectable markers may be introduced on the same plasmid as the gene(s) of interest or may be introduced on a separate plasmid.
  • B. Viral-Mediated Gene Transfer
  • A preferred approach for introducing nucleic acid encoding a gene product into a cell is by use of a viral vector containing nucleic acid, e.g. a cDNA, encoding the gene product. Infection of cells with a viral vector has the advantage that a large proportion of cells receive the nucleic acid, which can obviate the need for selection of cells which have received the nucleic acid. Additionally, molecules encoded within the viral vector, e.g., by a cDNA contained in the viral vector, are expressed efficiently in cells which have taken up viral vector nucleic acid and viral vector systems can be used either in vitro or in vivo.
  • 1. Retroviruses: Defective retroviruses are well characterized for use in gene transfer for gene therapy purposes (for a review see Miller, A. D. (1990) Blood 76:271). A recombinant retrovirus can be constructed having a nucleic acid encoding a gene product of interest inserted into the retroviral genome. Additionally, portions of the retroviral genome can be removed to render the retrovirus replication defective. The replication defective retrovirus is then packaged into virions which can be used to infect a target cell through the use of a helper virus by standard techniques. Protocols for producing recombinant retroviruses and for infecting cells in vitro or in vivo with such viruses can be found in Current Protocols in Molecular Biology, Ausubel, F. M. et al. (eds.) Greene Publishing Associates, (1989), Sections 9.10-9.14 and other standard laboratory manuals. Examples of suitable retroviruses include pLJ, pZIP, pWE and pEM which are well known to those skilled in the art. Examples of suitable packaging virus lines include φCrip, φCre, 2, and_Am. Retroviruses have been used to introduce a variety of genes into many different cell types, including epithelial cells, endothelial cells, lymphocytes, myoblasts, hepatocytes, bone marrow cells, in vitro and/or in vivo (see for example Eglitis, et al. (1985) Science 230:1395-1398; Danos and Mulligan (1988) Proc. Natl. Acad. Sci. USA 85:6460-6464; Wilson et al. (1988) Proc. Natl. Acad. Sci. USA 85:3014-3018; Armentano et al. (1990) Proc. Natl. Acad. Sci. USA 87:6141-6145; Huber et al. (1991) Proc. Natl. Acad. Sci. USA 88:8039-8043; Ferry et al. (1991) Proc. Natl. Acad. Sci. USA 88:8377-8381; Chowdhury et al. (1991) Science 254:1802-1805; van Beusechem et al. (1992) Proc. Natl. Acad. Sci. USA 89:7640-7644; Kay et al. (1992) Human Gene Therapy 3:641-647; Dai et al. (1992) Proc. Natl. Acad. Sci. USA 89:10892-10895; Hwu et al. (1993) J. Immunol. 150:4104-115; U.S. Pat. No. 4,868,116; U.S. Pat. No. 4,980,286; PCT Application WO 89/07136; PCT Application WO 89/02468; PCT Application WO 89/05345; and PCT Application WO 92/07573). Retroviral vectors require target cell division in order for the retroviral genome (and foreign nucleic acid inserted into it) to be integrated into the host genome to stably introduce nucleic acid into the cell. Thus, it may be necessary to stimulate replication of the target cell.
  • 2. Adenoviruses: The genome of an adenovirus can be manipulated such that it encodes and expresses a gene product of interest but is inactivated in terms of its ability to replicate in a normal lytic viral life cycle. See for example Berkner et al. (1988) BioTechniques 6:616; Rosenfeld et al. (1991) Science 252:431-434; and Rosenfeld et al. (1992) Cell 68:143-155. Suitable adenoviral vectors derived from the adenovirus strain Ad type 5 d1324 or other strains of adenovirus (e.g., Adz, Ad3, Ad7 etc.) are well known to those skilled in the art. Recombinant adenoviruses are advantageous in that they do not require dividing cells to be effective gene delivery vehicles and can be used to infect a wide variety of cell types, including airway epithelium (Rosenfeld et al. (1992) cited supra), endothelial cells (Lemarchand et al. (1992) Proc. Natl. Acad. Sci. USA 89:6482-6486), hepatocytes (Herz and Gerard (1993) Proc. Natl. Acad. Sci. USA 90:2812-2816) and muscle cells (Quantin et al. (1992) Proc. Natl. Acad. Sci. USA 89:2581-2584). Additionally, introduced adenoviral nucleic acid (and foreign DNA contained therein) is not integrated into the genome of a host cell but remains episomal, thereby avoiding potential problems that can occur as a result of insertional mutagenesis in situations where introduced nucleic acid becomes integrated into the host genome (e.g., retroviral DNA). Moreover, the carrying capacity of the adenoviral genome for foreign DNA is large (up to 8 kilobases) relative to other gene delivery vectors (Berkner et al. cited supra; Haj-Ahmand and Graham (1986) J. Virol. 57:267). Most replication-defective adenoviral vectors currently in use are deleted for all or parts of the viral E1 and E3 genes but retain as much as 80% of the adenoviral genetic material.
  • 3. Adeno-Associated Viruses: Adeno-associated virus (AAV) is a naturally occurring defective virus that requires another virus, such as an adenovirus or a herpes virus, as a helper virus for efficient replication and a productive life cycle. (For a review see Muzyczka et al. Curr. Topics in Micro. and Immunol. (1992) 158:97-129). It is also one of the few viruses that may integrate its DNA into non-dividing cells, and exhibits a high frequency of stable integration (see for example Flotte et al. (1992) Am. J. Respir. Cell. Mol. Biol. 7:349-356; Samulski et al. (1989) J. Virol. 63:3822-3828; and McLaughlin et al. (1989) J. Virol 62:1963-1973). Vectors containing as little as 300 base pairs of AAV can be packaged and can integrate. Space for exogenous nucleic acid is limited to about 4.5 kb. An AAV vector such as that described in Tratschin et al. (1985) Mol. Cell. Biol. 5:3251-3260 can be used to introduce nucleic acid into cells. A variety of nucleic acids have been introduced into different cell types using AAV vectors (see for example Hermonat et al. (1984) Proc. Natl. Acad. Sci. USA 81 :6466-6470; Tratschin et al. (1985) Mol. Cell. Biol. 4:2072-2081; Wondisford et al. (1988) Mol. Endocrinol. 2:32-39; Tratschin et al. (1984) J. Virol.51:611-619; and Flotte et al. (1993) J. Biol. Chem. 268:3781-3790).
  • The efficacy of a particular expression vector system and method of introducing nucleic acid into a cell can be assessed by standard approaches routinely used in the art. For example, nucleic acid introduced into a cell can be detected by a filter hybridization technique (e.g., Southern blotting) and RNA produced by transcription of introduced nucleic acid can be detected, for example, by Northern blotting, RNase protection or reverse transcriptase-polymerase chain reaction (RI-PCR). The gene product can be detected by an appropriate assay, for example by immunological detection of a produced protein, such as with a specific antibody, or by a functional assay to detect a functional activity of the gene product, such as an enzymatic assay. If the gene product of interest to be expressed by a cell is not readily assayable, an expression system can first be optimized using a reporter gene linked to the regulatory elements and vector to be used. The reporter gene encodes a gene product which is easily detectable and, thus, can be used to evaluate the efficacy of the system. Standard reporter genes used in the art include genes encoding beta-galactosidase, chloramphenicol acetyl transferase, luciferase and human growth hormone.
  • Cells Useful According to the Invention
  • The invention provides for host cells transfected with nucleic acid constructs encoding a multifunctional molecule of the invention. Host cells useful in the invention include but are not limited to the following.
  • A host cell can be any cell which is able to act as a carrier for an antigen according to the invention and thus may be a nucleated cell or a procaryotic cell into which nucleic acid can be artificially introduced. Procaryotic cells useful according to the invention include bacterial cells. Eucaryotic (nucleated) cells useful according to the invention include cells of a yeast, fungus, cells of a parasite and mammalian cells. Mammalian cells useful according to the invention include but are not limited to fibroblasts, including specialized mesenchymal cells such as a synoviocytes; keratinocytes, epithelial cells, endothelial cells, leukocytes and tumor cells.
  • Cell lines useful according to the invention include but are not limited to B16, CMS-5 fibrosarcoma cells, Cos1 cells and CHO cells, TS/A, Lewis lung carcinoma, RENCA, Dunning rat prostate carcinoma, and cell lines included in the catalogue of the American Type Culture Collection (Manassas, Va.).
  • Host cells comprising a nucleic acid molecule encoding a multifunctional molecule of the invention can be prepared from pathogenic cells according to the invention. Pathogenic cells include tumor cells (e.g. B16 cells, CMS-5 fibrosarcoma cells, and cells derived from the tumors included in the section entitled “Tumors for which the Invention is Useful”), and cells derived from pathogenic bacterium, pathogenic fungus, pathogenic virus, pathogenic parasite, or a pathogenic arthropod.
  • Methods of Detecting Expression From an Artificially Introduced Recombinant Nucleic Acid Sequence
  • The invention provides for methods of detecting a protein (e.g., a multifunctional molecule) that is expressed from a recombinant nucleic acid molecule that has been artificially introduced into a cell.
  • Preparation of Antibodies
  • Antibodies specific for a protein useful according to the invention (e.g., a multifunctional molecule) are useful for protein purification, and for the detection of expression of these proteins from cells into which a recombinant nucleic acid molecule expressing these proteins has been artificially introduced. By antibody, we include constructions using the binding (variable) region of such an antibody, and other antibody modifications. Thus, an antibody useful in the invention may comprise a whole antibody, an antibody fragment, a polyfunctional antibody aggregate, or in general a substance comprising one or more specific binding sites from an antibody. The antibody fragment may be a fragment such as an Fv, Fab or F(ab′)2 fragment or a derivative thereof, such as a single chain Fv fragment. The antibody or antibody fragment may be non-recombinant, recombinant or humanized. The antibody may be of an immunoglobulin isotype, e.g., IgG, IgM, and so forth. In addition, an aggregate, polymer, derivative and conjugate of an immunoglobulin or a fragment thereof can be used where appropriate.
  • Although a protein product (or fragment or oligopeptide thereof) of a protein according to the invention (e.g., a multifunctional molecule according to the invention) that is useful for the production of antibodies does not require biological activity, it must be antigenic. Antibodies may be directed to any portion of the multifunctional molecule of the invention. For example, an antibody may be directed to the lecting portion of the multifunctional molecule or to the ligand portion of the multifunctional molecule. Peptides used to induce specific antibodies may have an amino acid sequence consisting of at least five amino acids and preferably at least 10 amino acids. Preferably, they should be identical to a region of the natural protein and may contain the entire amino acid sequence of a small, naturally occurring molecule. Short stretches of amino acids corresponding to the protein product of a recombinant nucleic acid encoding a protein useful according to the invention (e.g., a multifunctional molecule according to the invention) may be fused with amino acids from another protein such as keyhole limpet hemocyanin or GST, and antibody will be produced against the chimeric molecule. Procedures well known in the art can be used for the production of antibodies to the protein products of recombinant nucleic acids of the invention.
  • For the production of antibodies, various hosts including goats, rabbits, rats, mice etc. may be immunized by injection with the protein products (or any portion, fragment, or oligonucleotide thereof which retains immunogenic properties) of the recombinant nucleic acid molecules encoding proteins useful according to the invention. Depending on the host species, various adjuvants may be used to increase the immunological response. Such adjuvants include but are not limited to Freund's, mineral gels such as aluminum hydroxide, and surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, and dinitrophenol. BCG (bacilli Calmette-Guerin) and Corynebacterium parvum are potentially useful human adjuvants.
  • I. Polyclonal Antibodies.
  • The antigen protein may be conjugated to a conventional carrier in order to increase its immunogenicity, and an antiserum to the peptide-carrier conjugate will be raised. Coupling of a peptide to a carrier protein and immunizations may be performed as described (Dymecki et al., 1992, J. Biol. Chem., 267: 4815). The serum can be titered against protein antigen by ELISA (below) or alternatively by dot or spot blotting (Boersma and Van Leeuwen, 1994, J. Neurosci. Methods, 51: 317). At the same time, the antiserum may be used in tissue sections prepared as described. A useful serum will react strongly with the appropriate peptides by ELISA, for example, following the procedures of Green et al., 1982, Cell, 28: 477.
  • 2. Monoclonal Antibodies.
  • Techniques for preparing monoclonal antibodies are well known, and monoclonal antibodies may be prepared using a candidate antigen (e.g., a mulispecific molecule or a lectin whose level is to be measured or which is to be either inactivated or affinity-purified, preferably bound to a carrier, as described by Arnheiter et al., 1981, Nature, 294;278.
  • Monoclonal antibodies are typically obtained from hybridoma tissue cultures or from ascites fluid obtained from animals into which the hybridoma tissue was introduced.
  • Monoclonal antibody-producing hybridomas (or polyclonal sera) can be screened for antibody binding to the target protein.
  • 3. Antibody Detection Methods
  • Particularly preferred immunological tests rely on the use of either monoclonal or polyclonal antibodies and include enzyme-linked immunoassays (ELISA), immunoblotting and immunoprecipitation (see Voller, 1978, Diagnostic Horizons, 2:1, Microbiological Associates Quarterly Publication, Walkersville, Md.; Voller et al., 1978, J. Clin. Pathol., 31: 507; U.S. Reissue Pat. No. 31,006; UK Patent 2,019,408; Butler, 1981, Methods Enzymol., 73: 482; Maggio, E. (ed.), 1980, Enzyme Immunoassay, CRC Press, Boca Raton, Fla.) or radioimmunoassays (RIA) (Weintraub, B., Principles of radioimmunoassays, Seventh Training Course on Radioligand Assay Techniques, The Endocrine Society, March 1986, pp. 1-5, 46-49 and 68-78). For analysing tissues for the presence or absence of a protein produced by a recombinant nucleic acid encoding a protein useful according to the invention (e.g., multifunctional molecule or portion thereof), immunohistochemistry techniques may be used. It will be apparent to one skilled in the art that the antibody molecule may have to be labelled to facilitate easy detection of a target protein. Techniques for labelling antibody molecules are well known to those skilled in the art (see Harlow and Lane, 1989, Antibodies, Cold Spring Harbor Laboratory).
  • Determining Whether an Immune Response is Modulated According to the Invention
  • The multifunctional molecules described herein are useful according to the invention to modulate an immune response in a mammalian, preferably a human, to an antigen or antigens contained in the antigen bearing target which is bound to the lectin portion of the multifunctional molecule. In one embodiment, a composition comprising a multifunctional molecule bound to an antigen bearing target is administered to an animal, preferably a human. The second portion of the multifunctional molecule comprising a ligand for a cell-surface molecule of an APC targets the composition to antigen presenting cells in the animal to which the composition has been administered. The antigen bearing target is taken up (i.e., ingested or phagocytosed) by antigen presenting cells. Alternatively, the multifunctional molecule/antigen bearing target complex is contacted with antigen presenting cells in vitro under conditions which allow phagocytosis, wherein the APCs are subsequently returned to the host organinsm from which they were derived.
  • The present invention thus provides a method for modulating an immune response in an mammal comprising administering to the mammal a composition comprising at least a multifunctional molecule as described herein. In one embodiment, the composition further comprises an antigen bearing target. In a further embodiment, the composition still further comprises an APC.
  • An “immune response” refers to stimulation/activation of a selected response involving the immune system, or suppression, elimination, or attenuation of a selected response. In a preferred embodiment, an immune response refers to stimulation/activation of a selected response involving the immune system by about at least 5%, or preferably between 5 and 50% or more preferably between 50 and 100% or at least 100% or greater, or suppression, elimination, or attenuation of a selected response by about at least 5%, or preferably between 5 and 50% or more preferably between 50 and 100% or at least 100% or greater, as compared to control cells that are not CD 40-ligand enhanced cells. Thus, to modulate an immune response means that the desired response is more efficient, more rapid, greater in magnitude, and/or more easily induced than when an antigen bearing target is contacted with an APC in the absence of a multifunctional molecule. Different immune responses in the subject may be modulated differentially, e.g., the cellular immune response may be selectively enhanced while the humoral response may be selectively attenuated, and vice versa.
  • The following in vitro and in vivo assays are useful for determining whether an immune response is modulated according to the invention. The assays described in detail below measure stimulation or suppression of cellular or humoral immune responses to an antigen. The antigens referred to in the following assays are representative. It will be apparent to one of skill in the art that an immune response to a selected antigen useful according to the invention may be measured using one or more of the following assays by adapting the assay to that antigen.
  • I. Detection of Increased Phagocytosis
  • The following assay may be used in order to determine whether opsonin-enhanced cells stimulate phagocytosis by antigen presenting cells.
  • Phagocytosis is examined using monocytes that have been adhered at 37° for 30 min in RPMI without added FCS. Sheep erythrocytes are incubated with an opsonin, or its precursor, under conditions such that there are no more than 300 of such molecules, on average, are deposited on each erythrocyte. If a precursor is used, coated erythrocytes are then processed to convert all precursors to the actual candidate molecule (e.g., See Carlo et al., J. Immunol. 123:523-8(1979)). Fresh monocytes are isolated from the subject, and 5×-1×105 of these cells suspended in 0.25-0.5 ml of RPMI medium with 1% BSA. This aliquot is placed in a tissue culture well and incubated for 30 min at 37° C. An excess of coated erythrocytes, suspended at 1.2×108 cells/ml, is overlain on the monocytes, the plate is centrifuged for 5 min at 50 g, and incubated for 30 min at 37° C. Non-ingested material is removed in two hypotonic lysis steps using ice-cold lysing buffer before fixing and staining the adherent cells, and examining the cells under light microscopy. Phagocytosis is quantified by determining the percentage of 100 monocytes ingesting one or more target cells, and the total number of ingested E/100 monocyptes (PI) is recorded. Stimulation of phagocytosis according to the invention is indicated by a phagocytic index of equal to or greater than 40.
  • Another assay for phagocytosis is as follows: Cells of the murine macrophage line are harvested and suspended in DMEM-10 at 4×105/ml. 2.0 ml of this suspension is aliquoted into individual 3.5 cm cell culture plates, and the dishes incubated at 37° C. in 5% CO2 overnight. Target cells, as well as control cells, are harvested on the same day as the macrophages, washed in PBS, and resuspended 2 min in PKH26 dye (a 2 μM solution in 1 ml of the supplied diluent) at 5×106 cells/ml. The fluorescent PKH26 dye emits in the red spectrum when excited, whereas the FITC label that is used for the phagocytes emits in the green spectrum. PKH26 is stable in the endosomal/lysosomal compartment of phagocytes. The dyed target cells are washed 3 times with PBS and cultured overnight to allow leaching of PKH26 out into the medium. This minimizes leakage of dye during the assay. The following day the target cells are harvested, washed 3 times with PBS, and resuspended in serum-free DMEM at 5×105/ml. The phagocytic cells are rinsed vigorously with PBS on the culture plates in order to remove serum, and 2 ml of target cells is added to each plate After 0, 2, 4, or 8 h, the plates are rinsed 3 times with PBS to remove all non-adhered cells and the remaining cells are incubated with 2 mM EDTA to release them from the plate. The released cells are washed with 1% FBS/PBS, and suspending in 100 μl of the same buffer. 2 μg anti-phagocyte (e.g. anti-CR3) antibody is added and the cells placed on ice for 25 min. The cells are washed 3 times with 1% FBS/PBS, resuspended in 100 μl of this solution, and stained with a 1:25 dilution of FITC-conjugated secondary IgG for 25 min on ice. Cells are washed 3 times and resuspended in 500 μl 1% FBS/PBS, then analyzed on a Becton Dickinson FACScan with CellQuest software.
  • FL-1 (green) fluorescence is used to gate phagocytes. The FL-2 (red) fluorescence of these cells, which reflects internalization of PKH26-labeled target cells, is then measured. Phagocytosis induced by, e.g., an opsonin is indicated by the difference between mean FL-2 fluorescence of macrophages incubated with opsonin-coated versus non-opsonin-coated target cells. Use of an opsonin will increase mean FL-2 fluorescence by, e.g. at least 10%., or enough to obtain ap value less than or equal to 0.05 by student t-test.
  • II. Amplification of the Immune Response Usually Involves Proliferation of Particular Subpopulations of Lymphoid Cells that are Normally in the Resting State.
  • Proliferative assays have the following applications in clinical studies: (1) Assessment of overall immunologic competence of T cells or B cells as manifested in their ability to respond to polyclonal proliferation signals such as mitogens or anti-CD3 antibodies. Defects in the proliferation may be indicative of fundamental cellular immunologic defect. Low proliferation is often found as a nonspecific secondary effect of chronic disease. (2) Assessment of an individual's response to specific antigens, where low responses are indicative of general or specific immunologic defect. (3) Determination of MHC compatibility by the mixed lymphocyte reaction (MLR).
  • In addition, proliferative assays are useful for estimating lymphokine production, investigating signal transduction, and assessing growth factor requirements (e.g., lymphokines) for T or B cells. The procedure outlined here measures incorporation of [3H]thymidine into DNA, which usually correlates well with cell growth as measured by changes in cell number. However, when the activation stimulus is toxic, as with chemical activators such as ionomycin plus phorbol myristate acetate (PMA), the burst of new DNA synthesis following activation may not be accompanied with a net increase in viable cells, and, in fact, a decline in cell number may be observed. In this instance, [3H]thymidine incorporation in DNA is more indicative of initial cell stimulation than estimation of cell number. In addition, [3H]thymidine incorporation provides information on cell populations, not on individual cells. Alternate methods, such as flow cytometry may be used for studies requiring that type of information.
  • Assay for Antigen-Induced T Cell Proliferation
  • This protocol is designed to test the proliferation of T cells in response to a specific antigen—tetanus toxoid. It can be modified to test T cell proliferation in response to any protein or polysaccharide antigen. Materials: (T cell suspension, autologous antigen-presenting cell suspension (non-T cells), Tetanus toxoid solution (Connaught or State Laboratory Institute of Massachusetts)). (1) Count T cells and adjust to 1×106 cells/ml with complete RPM1-10 AB. (2) Treat antigen-presenting cells with mitomycin C (or irradiate with 2500 rad) as in step 2 of one-way MLR protocol. Adjust concentration of antigen-presenting cells to 2×105 cells/ml. Antigen-presenting cells can consist of autologous non-T cells or autologous monocytes/macrophages. (3) Add 100 ul T cell suspension and 50 ul antigen-presenting cell population to wells; mix just before dispensing. (4) Add 50 ul tetanus toxoid solution to give final concentrations of 0, 1, 5, 10, and 20 ug/ml. Prepare three wells for each dilution. (5) Incubate 6 days in a humidified 37° C., 5% CO2 incubator. (6) Pulse with [3H]thymidine and harvest as described in support protocol.
  • Assay for Lymphokine-Dependent Cell Proliferation
  • This protocol assays the lymphokine-dependent proliferation of a lymphocyte population, in this case, the IL-4 dependent proliferation of B cells. Materials: (Tonsil B cell suspension, Anti-Img cross-linked to Sepharose beads (Bio-Rad), 10,000 U/ml human rIL-4 (Genzyme) in complete RPM1-10). (1) Count tonsil B cells and adjust concentration to 1×106 cells/ml with complete RPM1-10. (2) Dispense 100 ul of tonsil B cells into each well. Prepare three wells for each experimental condition. (3) Dilute 10,000 U/ml rIL-4 solution 1:10, 1:100, and 1:1000. Add 20 ul of the stock or dilution to appropriate wells to yield 1000 U/ml, 100 U/ml, 10 U/ml, and 1 U/ml. Include a control well with no rIL-4. (4) Pipet anti-IgM beads into appropriate wells.
  • Determine the optimal concentration of beads with pilot experiments. It is best to include several concentrations of beads in each experiment to “bracket” the optimal dose. Prepare wells with tonsil B cells and IL-4 dilutions alone, anti-IgM beads alone, culture medium alone, and all the combinations of IL-4 and anti-IgM bead dilutions. (5) Increase the volume of each well to 200 ul with complete RPM1-10 as necessary. (6) Culture 5 days in a humidified 37° C., 5% CO2 incubator. (7) Pulse with [3H]thymidine and harvest as described in support protocol.
  • [3H]Thymidine Pulse and Harvest of Cell Cultures
  • This protocol is used in conjunction with the preceding protocols to complete the [3H] thymidine incorporation assay. (1) Add 20 ul of 50 uCi/ml [3H]thymidine to each culture (1.0 uCi) at a fixed time before terminating the culture (usually 6 or 18 hr). (2) Harvest cell cultures using an automated multiwell harvester that aspirates cells, lyses cells, and transfers DNA onto filter paper, while allowing unincorporated [3H]thymidine to wash out. Fill and aspirate each row of the microtiter plate ten times to ensure complete cell transfer and complete removal of unincorporated thymidine. Wash each filter strip with 100% ethanol to facilitate drying. Transfer to scintillation vials. For semiautomated harvester, transfer filter dots for each well into scintillation counting vials. For manual transfer, dry filters under lamp and transfer to scintillation vial with forceps. Add scintillation fluid to each vial. (3) Count samples in scintillation counter until standard deviation is less than 2%. Calculate mean cpm for background cultures and for each experimental condition. There should be less than 20% variation in replicate cultures.
  • III. Induction and Measurement of In Vitro Antibody Responses
  • The capacity of the human immune system to mount an antibody response following in vivo immunization with a protein or polysaccharide antigen is a revealing indication of the overall integrity of both the B and T cell arms of the immune system. As such, in vivo immunization followed by measurement of the antibody response is an appropriate test of immune function in the various acquired and congenital immunodeficiencies and in a host of other conditions affecting the immune system. The following procedures are for in vivo immunization and for the measurement of the subsequent immune response using an ELISA technique.
  • Immuno-Enzymetric Assay for Cytokines Using NIP- and HRPO-Labeled Antibodies
  • This protocol describes an immunonoenzymetric assay for cytokines using a heterogeneous, noncompetitive immunoassay reaction in which the cytokine is immobilized by a coating antibody bound to a microtiter plate. Unbound material is washed free, and detection is carried out using a different anti-cytokine antibody labeled with the hapten nitroiodophenyl (NIP). This is in turn detected by a horseradish peroxidase (HRPO) conjugate of an anti-NIP antibody, which is revealed with the chromogenic substrate ABTS. In this noncompetitive immunoassay, the immunoassay signal (A405) increases as a direct function of the amount of cytokine present in the sample. Antibodies are prepared as described in Current Protocols in Immunology, 1995, 6.20.2-6.20.10.
  • Coat assay plate. (1) Using a multichannel pipettor, transfer 100 ul of an appropriate dilution of coating antibody into all wells of the assay plate that are to be used. (2) Seal plates with microtiter plate sealer or Parafilm and incubate 2 hr. At 37° C. Prepare samples and standards in preparation plate. (3) Dilute each sample (or aliquot of conditioned medium) to be assayed with an equal volume of immunoassay diluent. (4) Pipet less than or equal to 1 ml of each diluted sample to be assayed into the upper chamber of a separate Spin-X microfiltration device. Microcentifuge 5 min. At 10,000 rpm and save the filtrates that collect in the lower chambers. (5) Add 65 ul of each diluted sample to the appropriate well of a preparation plate (i.e., a separate 96-well microtiter plate). (6) Thaw an aliquot of cytokine standard at room temperature and make sure that it is well mixed. Pipet 130 ul into the well of the preparation plate representing the highest concentration on the standard curve. Transfer 65 ul from this well into the next, then continue performing serial 1:1 dilutions in immunoassay diluent so that 65 ul of each concentration represented on the standard curve is placed in appropriate well of the preparation plate. (7) Thaw an aliquot of calibrator at room temperature (if used). Dilute with an equal volume of immunoassay diluent, then pipet 65 ul of diluted calibrator into appropriate well or wells of preparation plate.
  • Incubate with coating antibody. (8) Remove coated assay plate from incubator. Dip in 2-liter beaker filled with 1× with buffer, then invert over sink and flick to remove liquid. Repeat two more times, then bang dry on paper towel. (9) Transfer 50 ul of solution from each well of preparation plate to corresponding well of the assay plate using multichannel pipettor. (10) Seal plate with microtiter plate sealer or Parafilm and incubate 2 hr. at room temperature.
  • Incubate with detecting antibody. (11) Dilute NIP-labeled detecting antibody specific to cytokine of interest to 1 ug/ml in detecting buffer. (12) Wash assay plate as in step 8. (13) Add 75 ul diluted detecting antibody from step 11 to all wells of assay plate, including unused outer walls. (14) Reseal plate with microtiter plate sealer or Parafilm and incubate 1 hr. at room temperature.
  • Incubate with HRPO-conjugated anti-NIP antibody. (15) Dilute HRPO-conjugated anti-NIP Mab 1:3000 in detecting buffer. (16) Wash assay plate as in step 8. (17) Add 75 ul of diluted HRPO-labeled anti-NIP antibody from step 15 to all wells of assay plate. (18) Reseal plate with microtiter plate sealer or Parafilm and incubate 1 hr. at room temperature.
  • Incubate with chromogenic substrate. (19) Wash assay plate as in step 8. (20) Add 100 ul ABTS substrate working solutions to all wells of assay plate. Cover plate and incubate at room temperature until color development reaches desired level (generally until A405 for wells containing the highest concentration of standard is between 1.5 and 2). This protocol usually produces an assay that can be read after 30 to 60 min.
  • Read plate and analyze data. (21) Using microtiter plate reader with computer interface, measure absorbance in all wells at 405 nm in single-wavelength mode or at 405 and 650 nm in dual-wavelength mode. (22) Fit standard data to a curve described by a first-degree (linear), second degree (quadratic), or four-parameter (nonlinear) mathematical function using curve-fitting software. (23) Interpolate absorbance data from unknown cytokine samples to fitted standard curve, and calculate cytokine concentrations.
  • IV. Induction of an In Vivo Antibody Response Provides an Approach to the Evaluation of the Overall Integrity of the Immune System.
  • In the protocols presented here, diptheria and tetanus toxoids are used as representative protein antigens and pneumococcal polysaccharides are used as representative polysaccharide antigens because of their safety and availability. It should be noted, however, that the responses elicited by these antigens are likely to be secondary responses because of past vaccination or natural exposure. To obtain a primary response, an unusual antigen such as keyhole limpet hemocyanin should be used.
  • When antigens are administered by the intramuscular or subcutaneous route, as they are here, a “systemic” immune response is induced and measurement of circulating antibody is most appropriate. It is, however, sometimes of interest to evaluate “local” or mucosal immune responses. In this case, the antigen is given either intranasally to stimulate respiratory lymphoid tissue or orally to stimulate gastrointestinal lymphoid tissue and bronchial washings or intestinal fluids, rather than blood, is assayed for antibody content; in addition, antigens are used that are more appropriate for stimulation of the local/mucosal response (i.e., influenza virus antigen for respiratory responses and cholera toxin for gastrointestinal responses).
  • In assaying the in vivo antibody response, it is important to determine responses to both protein and polysaccharide antigens because these antigens stimulate different components of the immune system. In this regard, the major antibody response to protein antigen is composed of IgG1 and IgG3 subclass antibodies, whereas the major antibody response to polysaccharide antigen is composed of IgG2 subclass antibody.
  • A variety of immunoassay techniques have been used to measure antibody responses in materials obtained after in vivo immunization. Of these, the ELISA assay is perhaps the most useful because it yields a stable, easily measurable, reproducible, and safe readout.
  • Induction of In Vivo Antibody Responses to Protein/Polysaccharide Antigens
  • In this protocol antigens are administered by the intramuscular or subcutaneous route and serum is collected for measurement of responses. (1) Draw preimmunized blood sample, allow blood to clot, and separate serum from clot by centrifugation. Store serum at −20° C. to −70° C. in appropriately labeled plastic tubes. (2) Inject 0.5 ml of toxoid mixture into an appropriately prepared intramuscular site (deltoid or thigh), taking care not to inject material intravenously. (3) Inject 0.5 ml polyvalent pneumococcal vaccine into an appropriately prepared subcutaneous site, taking care not to inject material intravenously. (4) Draw post-immunization blood samples at desired intervals, usually at 1, 2, and 3 weeks. Separate serum and store at −20° C. to −70° C. (5) After all serum samples are collected, assay samples for presence of antibodies using ELISA.
  • The ELISA offers a rapid, sensitive, reproducible, nonradioactive method for measuring in vivo antibody responses to a variety of antigens, including protein and polysaccharide antigens in sera obtained from individuals vaccinated with tetanus and diphtheria boosters and the polyvalent pneumococcal polysaccharide vaccine. Assays specific for tetanus, diphtheria and the pneumococcal polysaccharide types I, II, and III are detailed in Current Protocols in Immunology, 1995, Vols. 6 and 7.
  • Assay Using Tumor Rejection
  • In another assay for immunomodulation, an immunocompent animal is vaccinated with on the order of 104-108 irradiated cytokine-coated tumor cells, and challenged with on the order of 104-108 live wild-type tumor cells (in any temporal sequence). If survival or tumor onset in these animals differs from that of animal vaccinated, using identical parameters, with irradiated non-cytokine coated cells instead of opsonin-enhanced cells, immunomodulation has occurred. For example, if at least 10% of the animals in the test group survive 100% longer than mean survival in the control group, the test is positive. As another example, onset of tumors in 20% of the test animals might be 50% later than mean onset in the control animals.
  • Dosage and Administration
  • The invention encompasses methods of modulating an immune response in a mammal to a selected antigen, the method comprising administering to a mammal a therapeutic amount of a composition comprising a multifunctional molecule as described herein, or a composition comprising a multifunctional molecule of the invention and an antigen bearing target, or administering a composition comprising a therapeutic amount of APCs which have been contacted with a multifunctional molecule and antigen bearing target in vitro.
  • Compositions described herein may be prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for solution in or suspension in, liquid prior to infection can also be prepared. The preparation can also be emulsified, or encapsulated in liposomes. The active immunogenic ingredients are often mixed with carriers which are pharmaceutically acceptable and compatible with the active ingredient. The term “pharmaceutically acceptable carrier” refers to a carrier that does not cause an allergic reaction or other untoward effect in subjects to whom it is administered. As used herein, a “pharmaceutically acceptable carrier” does not include culture medium, or any solution containing about 0.2-2% serum or greater. Suitable pharmaceutically acceptable carriers include, for example, one or more of water, saline, phosphate buffered saline, dextrose, glycerol, ethanol, or the like and combinations thereof. In addition, if desired, the vaccine can contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents, and/or adjuvants which enhance the effectiveness of the vaccine. Examples of adjuvants which may be effective include but are not limited to: aluminum hydroxide, N-acetyl-muramyl-L-threonyl-D-isoglutamine (thr-MDP), N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine (CGP 11637, referred to as nor-MDP), N-acetylmuramyl-L-alanyl-D-isoglutaminyl-alanine-2-1′-2′-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy)-ethylamine (COP) 19835A, referred to as MTP-PE), and RIBI, which contains three components extracted from bacteria, monophosporyl lipid A, trehalose dimycolate and cell wall skeleton (MPL+TDM+CWS) in a 2% squalene/Tween 80 emulsion. Other examples of adjuvants include DDA (dimethyldioctadecylammonium bromide), Freund's complete and incomplete adjuvants and QuilA. In addition, immune modulating substances such as lymphokines (e.g., IFN-, IL-2 and IL-12) or synthetic IFN-inducers such as poly I:C can be used in combination with adjuvants described herein.
  • Compositions of the invention can be administered parenterally, by injection, for example, either subcutaneously or intramuscularly. Additional formulations which are suitable for other modes of administration include suppositories, and in some cases, oral formulations or formulations suitable for distribution as aerosols. In the case of the oral formulations, the manipulation of T-cell subsets employing adjuvants, antigen packaging, or the addition of individual cytokines to various formulations can result in improved oral vaccines with optimized immune responses. For suppositories, traditional binders and carriers may include, for example, polyalkylene glycols or triglycerides; such suppositories may be formed from mixtures containing the active ingredient in the range of 0.5% to 10%, preferably 1%-2%. Oral formulations include such normally employed excipients as, for example, pharmaceutical grades of mannitol, lactose, starch magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, and the like. These compositions take the form of solutions, suspensions, tablets, pills, capsules, sustained release formulations or powders and contain 10%-95% of active ingredient, preferably 25-70%.
  • The compositions of the invention can be formulated into the vaccine compositions as neutral or salt forms. Pharmaceutically acceptable salts include the acid addition salts (formed with free amino groups of the peptide) and which are formed with inorganic acids such as, for example, hydrochloric or phosphoric acids, or with organic acids such as acetic, oxalic, tartaric, maleic, and the like. Salts formed with the free carboxyl groups can also be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium, or ferric hydroides, and such organic bases as isopropylamine, trimethylamine, 2-ethylamino ethanol, histidine, procaine, and the like.
  • Any cellular component of such vaccine compositions can, in preparation for inclusion in such compositions, be subjected to treatments which involve attenuation or inactivation of the cells of the vaccine, including, for example, exposure to ionizing radiation, which can inhibit cell division, antiproliferative agents such as cyclophosphamide, cytochalasin D, or colchicine, or killing with or without fixation.
  • The compositions, including antigen bearing targets and APCs are administered in a manner compatible with the dosage formulation, and in such amount as will be prophylactically and/or therapeutically effective. The quantity to be administered depends on the subject to be treated, including, e.g., capacity of the subject's immune system to synthesize antibodies, and the degree of protection desired. Suitable dose ranges are on the order of several hundred micrograms active ingredient per vaccination with a preferred range from about 0.1 μg to 1000 μg, such as in the range from about 1 μg to 300 μg, and preferably in the range from about 10 μg to 50 μg. Suitable regiments for initial administration and booster shots are also variable but are typified by an initial administration followed by subsequent inoculations or other administrations. Precise amounts of active ingredient required to be administered depend on the judgment of the practitioner and may be peculiar to each subject. It will be apparent to those of skill in the art that the therapeutically effective amount of cells of this invention will depend, inter alia, upon the administration schedule, the unit dose of antigen administered, whether the cells are administered in combination with other therapeutic agents, the immune status and health of the recipient, and the therapeutic activity of the particular composition.
  • The compositions can be given in a single dose schedule, or preferably in a multiple dose schedule. A multiple dose schedule is one in which a primary course of vaccination can include 1-10 separate doses, followed by other doses given at subsequent time intervals required to maintain and or reinforce the immune response, for example, at 1-4 months for a second dose, and if needed, a subsequent dose(s) after several months. Periodic boosters at intervals of 1-5 years, usually 3 years, are preferable to maintain the desired levels of protective immunity. The course of the immunization can be followed by in vitro proliferation assays of peripheral blood lymphocytes (PBLs) co-cultured with ESAT6 or ST-CF, and by measuring the levels of IFN-released from the primed lymphocytes. The assays can be performed using conventional labels, such as radionucleotides, enzymes, fluorescent labels and the like. These techniques are known to one skilled in the art and can be found in U.S. Pat. Nos. 3,791,932, 4,174,384 and 3,949,064, which are hereby incorporated by reference.
  • Tumors for Which the Invention is Applicable
  • The invention contemplates treatment of tumors including but not limited to the following:
  • Melanomas, squamous cell tumors, basal cell carcinomas, astrocytomas, gliomas, glioblastoma multiforme, meningiomas, ependymomas, schwannomas, neuroblastomas, retinoblastomas, meningiomas, glomus tumors, sarcomas, including, e.g., osteosarcomas, Ewing's sarcomas, chondrosarcomas, myosarcomas, synovial cell sarcomas, fibrosarcomas, spindle cell tumors, angiosarcomas, primitive neuroectodermal cell tumors, and Kaposi's sarcomas, lymphomas, acute and chronic leukemias, tumors of the head and neck, nasopharyngeal carcinomas, carcinomas of the pharynx, laryngeal carcinomas, carcinomas of the thyroid, carcinomas of the parathyroids, thymomas, esophageal carcinomas, gastric carcinomas, tumors of the small bowel, carcinomas of the colon and rectum, mesotheliomas, lung carcinomas, including adenocarcinomas, squamous cell carcinomas, bronchoalveolar carcinomas, and small cell tumors, pancreatic carcinomas, islet cell and non-islet cell tumors, carcinomas of the breast, cardiac myxomas, pituitary tumors, carcinoid tumors, nepatomas, cholangiocarcinomas, hepatoblastomas, renal cell carcinomas, nephroblastomas, Wilms' tumors, adrenal carcinomas, pheochromocytomas, germ cell tumors, choriocarcinomas, ovarian carcinomas, testicular tumors, seminomas, endometrial tumors, carcinomas of the prostate, carcinomas of the seminal vesicles, vaginal tumors, carcinomas of the penis, hydatiform moles, carcinomas of the gall bladder, and carcinomas of the urinary bladder.
  • Subjects for Treatment According to the Invention
  • The present invention provides a method for reducing the size and/or number of metastases in a subject. The method comprises administering to the subject a vaccine composition comprising a multifunctional molecule of the invention. A “subject” as used herein, may refer to an organism of the Kingdom animalia, preferably a mammal, and still more preferably a human. A “subject”, according to the invention may also be an animal in need of anti-metastases therapy, e.g., a patient with malignant metastases to one or more organs or tissues, e.g., a human patient with lung or lymph node metastases. A “subject”, according to the invention may also be an animal model of metastases, in which the animal is manipulated, either genetically, or by injection of malignant cells, or by other methods known to those of skill in the art, to simulate the appearance of foci of malignant cells or infected cells which are observed in a similar animal with naturally occurring metastases. The generation of animal models of metastasis is well known in the art, and examples of such models may be found in, for example, Ryan M H et al., J. Immunol. 2001;167:4286-92; Specht J M et al., J Exp Med. 1997;186:1213-21; Nakanishi et al., Tumour Biol. 2003 24:70-6; Wang et al., Int J Gastrointest Cancer, 2001;29(1):37-46; Muralidharan et al., J Clin Laser Med Surg. 2003 21(2):75-83; Tanaka et al., Chest 2003, 123(4):1248-53; Huang et al., Clin Exp Metastasis 2002;19(4):359; and Irvine K R et al., J. Immunol. 1996;156:238-45. One of skill in the art would be able to readily adapt the animal models of metastasis known in the art to generate a metastasis model of interest for any given application.
  • Detection of Metastases
  • The present invention provides a method of reducing the number and/or size of metastases in a subject comprising administering to a subject, a multifunctional molecule as described herein. One of skill in the art will recognize that the detection and measurement of metastases is routine in the art and may be accomplished using well established methods. For example, metastases may be detected using gross examination of a subject, such as exploratory surgery (e.g., laparotomy). Alternatively, metastases may be detected, measure, and/or observed using less invasive techniques and methods such as thorascopy, mediastinoscopy, and laparoscopy. One of skill in the art may also detect the presence of metastases using imaging techniques known to those of skill in the art. Such techniques include, but are not limited to radiographic imaging, computerized tomography (CT scan), magnetic resonance imaging (MRI), positron emission tomography (PET scan), single photon excitation (SPECT), and radionuclide scintigraphy (e.g., bone scan). The sensitivity of many of the above imaging methods may be enhanced, as known by those of skill in the art by injection or IV administration of contrast agents (e.g., iodine or barium) to a subject to be imaged. Additional methods for assessing the presence of, or detecting, or measuring metastasis is through the use of gross or histological pathologic examination (i.e., in which a tissue sample is removed from a subject an examined at eaither or both of the gross anatomical level, or at the histological or ultrastructural level according to methods which are well known in the art). The above methods for the detection, measurement, and imaging of metastases are known to those of skill in the art and may be adapted according to the knowledge in the art to particular tissues, organs, or cells which one of skill in the art wishes to asses according to the methods of the invention. More detailed descriptions of such methods may be found in the art, for example, the Oxford Textbook of Oncology, 2nd Ed., New York, Oxford University Press, 2002.
  • According to the invention, metastasis is detected if any amount of metastasis is detected in a subject. That is, upon the detection of even a single foci in a subject, metastasis may be said to have been detected. Preferably, metastasis is detected as plural metastatic foci, in one or preferably one or more organs in a subject.
  • Transgenic Animals According to the Invention
  • A nucleic acid molecule encoding a multifunctional molecule as described herein can be used to produce nonhuman transgenic animals, and cells of such transgenic animals can be isolated and used in a vaccine formulation in animal or human vaccination.
  • For example, in one embodiment, a nucleic acid molecule is introduced into a fertilized oocyte or an embryonic stem cell. Such cells can then be used to create non-human transgenic animals in which exogenous nucleic acid molecules encoding the polypeptides of the invention have been introduced into their genome or homologous recombinant animals in which endogenous nucleic acid molecules have been altered. Such animals are useful for studying the function and/or activity of the molecules of the invention and for identifying and/or evaluating modulators of the activity of the molecules of the invention. As used herein, a “transgenic animal” is a non-human animal, prefers mammal, more preferably a mouse, in which one or more of the cells of the animal includes a transgene. A transgene is exogenous nucleic acid which is integrated into the genome of a cell from which a transgenic animal develops and which remains in the genome of the mature animal, thereby directing the expression of an encoded gene product in one or more cell types or tissues of the transgenic animal.
  • A transgenic animal of the invention can be created by introducing nucleic acid molecules encoding the polypeptides described herein (i.e., a multifunctional molecule) into the male pronuclei of a fertilized oocyte, e.g., by microinjection, and allowing the oocyte to develop in a pseudopregnant female foster animal. Intronic sequences and polyadenylation signals can also be included in the transgene to increase the efficiency of expression of the transgene. A tissue-specific regulatory sequence(s) can be operably linked to the transgene to direct expression of a polypeptide of the invention to particular cells. Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866 and 4,870,009, both by Leder et al., U.S. Pat. No. 4,873,191 by Wagner et al. and in Hogan, B., Manipulating the Mouse Embryo, (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1986). Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the nucleic acid molecule of the invention, e.g., the transgene in its genome and/or expression of the transgene mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene encoding polypeptides of the invention can further be bred to other transgenic animals carrying other transgenes.
  • The invention is further illustrated by the following exemplifications which should not be construed as being further limiting.
  • EXAMPLES Example 1 Cloning of a Murine GM-CSF Fused to the S. cerevesiae Gas1 GPI Modification Signal Sequence
  • The starting point for producing a yeast expression vector was the pUC 19-GM-CSF-mammalian GPI signal sequence plasmid (pUC19-GM-CSF-GPI). This plasmid encodes murine GM-CSF (upstream) fused in-frame to the human Thy-1 GPI modification signal sequence (downstream). The following two oligonucleotides were purchased from Midland Certified Reagent Company (Midland, Tex.):
    GTX-5
    5′pAATTCCGCGCCGGCACAGTGCTCAGAGACAAACTGGTCAAGTGTGAG
    GGCATCAGCCTGCTGGCTCAGAACACCTCGTGGCTGCTGCTGCTCCTGCT
    GTCCCTCTCCCTCCTCCAGGCCACGGATTTCATGTCCCTGTGACTGGGTA
    C3′

    GTX-5 comprises:
    • a. Sequences at the 5′ end suitable for ligating to an EcoRI site (bases 1-5)
    • b. An NgoM1 site for creating an in-frame chimeric coding sequence (bases 9-14)
    • c. The coding sequence for the GPI modification sequence of human Thy-1 (Genbank Accession No. M11749) (bases 15-137)
    • d. A termination codon (bases 138-140)
  • e. Sequences at the 3′ end for ligating to a KpnI site (bases 144-148)
    GTX-6
    5′pCCAGTCACAGGGACATGAAATCCGTGGCCTGGAGGAGGGAGAGGGAC
    AGCAGGAGCAGCAGCAGCCACGAGGTGTTCTGAGCCAGCAGGCTGATGCC
    CTCACACTTGACCAGTTTGTCTCTGAGCACTGTGCCGGCGCGG3′
  • This oligonucleotide is complementary to GTX-5, except for staggered ends.
  • GTX-5 and GTX-6 were dissolved in individual tubes in sterile water at a final concentration of 1 microgram/lambda. GTX-5 and GTX-6 were mixed at a final concentration of 100 ng/lambda and allowed to anneal for 60 minutes at room temperature.
  • The GTX-5:GTX-6 double stranded oligonucleotide was then cloned into the plasmid pUC19. Four micrograms of pUC19 DNA was digested with EcoRI and KpnI. After electrophoresis, the linear DNA was purified from a 0.7% agarose gel using a Qiagen (Santa Clarita, Calif.) gel purification kit according to instructions provided by the manufacturer. 100 ng of the GTX-5:GTX-6 oligonucleotide was ligated to 200 ng of the EcoRI-KpnI digested pUC19 in a final volume of 20 microliters at room temperature for 60 minutes.
  • The plasmid was transformed into competent AG-1 cells, which were purchased from Stratagene. Transformed E. coli were inoculated onto LB-amp plates. Bacterial colonies grown on LB plates containing ampicillin (100 micrograms/ml) were picked and inoculated into one ml of LB with amp and grown overnight at 37° with shaking.
  • Plasmid DNA was isolated using a standard alkaline lysis miniprep protocol and DNA was digested with EcoRI and KpnI. DNA was electrophoresed on 1.6% agarose gels stained with ethidium bromide, and colonies containing an EcoRI-KpnI fragment of approximately 148 bp were thus identified. Positive colonies were inoculated into 100 ml of LB with ampicillin and grown overnight. Plasmid DNA was again purified using kits purchased from Qiagen.
  • The nucleotide sequence of a Thy-GPI positive clone, designated pUC-GPI 21, was sequenced, confirming its identity.
  • The GM-CSF coding sequence was amplified by PCR from a mouse lung cDNA library purchased from Clontech. PCR was performed for 35 cycles using pfu polymerase and the following primers:
    Upstream
    5′CCGAATTCATGTGGCTGCAGAATTTACTTTTCCTGGGCATTGTGGTCT
    AC3′
    Downstream
    5′CAGCCGGCTTTTTGGACTGGTTTTTTGCATTCAAAGGGGATATCAGTC
    AG3′
  • PCR parameters were denaturation at 90° for 1 minute, annealing at 60° for 1 minute, and extension at 720 for 1 minute.
  • The GM-CSF chain PCR product was purified after electrophoresis through a 1% agarose gel. The DNA band was excised and the DNA fragment purified using a kit purchased from Qiagen.
  • The purified GM-CSF DNA fragment was digested with EcoRI and NgoM1. After digestion, the reaction mix was extracted with phenol:chloroform (1:1) followed by chloroform. The aqueous phase was adjusted to 0.3M sodium acetate pH 5.2 and the DNA was precipitated with 2 volumes of ethanol at −80° for 2 hours. The DNA was pelleted by centrifugation, ethanol was removed, and the pellet was rinsed with 70% ethanol. The pellet was dried under vacuum.
  • The GM-CSF DNA was resuspended in sterile water and ligated to pUC19-GPI 21 that had been digested with EcoRI-NgoM1. Ligation was for one hour at room temperature. PUC19 GPI 21 ligated to GM-CSF DNA was used to transform competent AG-1 cells. Transformed AG-1 cells were selected on LB plates with ampicillin. Plasmid DNA was isolated and analyzed as above. Restriction digests were performed to confirm the pUC 19 GPI-GM-CSF chimeric construct. The DNA from several positive clones was isolated and sequenced.
  • This plasmid was digested with NgoMIV and KpnI, and the larger resulting fragment isolated after electrophoresis through a 1% agarose gel.
  • The 280 bp GPI modification signal sequence from the yeast protein Gas1 was amplified by PCR from the yeast cosmid clone C9952 (ATCC). This PCR employed pfu polymerase and the primers:
    Upstream Primer
    5′GTAGCCGGCGCTAGCTCGGGGTCTTCTTCCAAGTCTA
    Downstream Primer
    5′TACGGTACCCCTAGGCCACAATGAAATAAGATACCATACC3′
  • These primers add a 5′ NgoMIV site and a 3′ KpnI site to the Gas I fragment.
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute
    Cycles 25
  • The PCR product was purified after electrophoresis through a 1% agarose gel and digested with NgoM IV and KpnI. The Gas1 GPI signal sequence was then ligated into the pUC19-GM-CSF-GPI plasmid prepared above so that the Gas1 signal sequence was fused in-frame downstream of the GM-CSF sequence, replacing the Thy-1 sequence. This vector is termed pUC19-GMCSF-Gas1.1. The resultant plasmid was then transformed into AG-1 competent E. coli (Stratagene) and plasmid clones were isolated by alkaline lysis mini-prep. Plamids were then screened for inserts by restriction digest. DNA from a positive clone was sequenced to confirm the identity of the GAS1 coding region.
  • A yeast expression plasmid for GPI-GM-CSF was then generated utilizing the pITY-4 vector, which was kindly provided by Dr. K. Dane Wittrup (University of Illinois). This plasmid stably integrates into the yeast genome and allows high-level expression of heterologous genes. Features of pITY-4 include: a delta sequence (LTR of Ty element) that enables multiple integration events by homologous recombination; a neo/kanamycin resistance gene that provides for selection in E. coli and tunable selection in yeast; the Gal1 promoter for high-level inducible transcription; a unique EagI cloning site; a synthetic Pre-Pro sequence optimized for efficient secretion of expressed genes; the alpha factor termination sequence; and an origin of replication for propagation in E. coli. In this system, yeast are grown in dextrose-containing media for 3 days, then are switched to media containing galactose to induce transcription of genes inserted downstream of the Gal1 promoter.
  • The GMCSF-Gas1 insert described above was amplified by PCR from pUC 19-GMCSF-Gas1.1 using pfu polymerase and the primers:
    Upstream
    5′TACGGCCGGCACCCACCCGCTCACCC3′
    Downstream
    5′TACGGCCGCCACAATGAAAATAAGATACCAT3′

    These primers add EagI sites at both ends for cloning into the pITY-4 plasmid.
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute
    Cycles 25
  • The PCR product was purified after electrophoresis through a 1% agarose gel and digested with EagI. The EagI-flanked GMCSF-Gas1 fragment was ligated into EagI-digested pITY-4 and used to transform E. coli AG1 cells. E. coli were then grown on kanamycin-containing LB plates (100 ug/ml). Plasmids from kanamycin resistant colonies were purified by mini-prep and mapped by restriction digests for presence and correct orientation of inserts. The identity of a positive clone was confirmed by sequencing. This plasmid is termed pITY-GMCSF-Gas1.1.
  • Example 2 Expression of Murine GM-CSF Fused to the Gas1 GPI Modification Signal Sequence in Yeast
  • A 50 ml culture of the E. coli clone containing pITY-GMCSF-Gas1.1 was grown in LB with 100 ug/ml kanamycin and the plasmid purified using a Midi-Prep Kit from Qiagen. The S. cerevesiae strain BJ5464 (ATCC) was then transformed with pITY-GMCSF-Gas 1.1 using a lithium acetate (LiAc) protocol. A 10 ml overnight culture of BJ5464 in YPD (Per liter: 20 g Bactotryptone, 10 g yeast extract, 20 g dextrose) was used to inoculate a 100 ml flask. Yeast were grown for 3 hours at 30° and then harvested by centrifugation at 12,000×g for 2 minutes at room temperature. Cells were washed with sterile water and centrifuged again. The cells were resuspended in 1.0 ml of 100 mM LiAc, transferred to a 1.5 ml microfuge tube and centrifuged in an Eppendorf microfuge at top speed for 15 seconds. The cells were then resuspended in 0.5 ml of 100 mM LiAc and 50 uL samples were aliquoted to individual tubes. The cells were pelleted. 240 uL of PEG (50% w/v), 36 uL 1.0M LiAc, 5 uL (10 mg/ml) boiled carrier DNA (salmon sperm DNA, Sigma), and 2 ug plasmid in 75 uL water, were then added in that order. After the addition of plasmid, the tube was vortexed, incubated at 30° for 30 minutes and heat-shocked at 42° for 15 minutes. The cells were then pelleted, resuspended in sterile water and plated on YPD plates containing 1 mg/ml G418.
  • Individual colonies of G418-resistant yeast were picked and grown in one ml of YPD with 1 mg/ml G418 for 3 days. The cells were then pelleted by centrifugation in a microfuge and the YPD (dextrose-containing, galactose-free) media was replaced with YPG (20 g bactotryptone, 10 g yeast extract, 20 g galactose per liter) with 1 mg/ml G418. Yeast were grown in YPG for 3 days to allow full induction of transcription from the Gal1 promoter. After induction, cells were pelleted, washed with TN (0.15M NaCl, 25 mM Tris pH 7.4) and lysed in TN containing 20 mM octyl glucopyranoside (OGP), 1 mM PMSF, and lug/ml each aprotinin, leupeptin and pepstatin. Yeast were lysed by vortexing with acid-washed glass beads (425-600 microns, Sigma). Insoluble material was pelleted and the supernatant assayed using a murine GM-CSF ELISA (Endogen). A colony expressing high levels of GPI-GM-CSF was identified. Based on standard curve of soluble GMCSF, we estimate expression to be approximately 25 ug/L, a significant improvement over mammalian expression and sufficient for in vivo experiments. This yeast clone is designated SC-GM-GPI.
  • One of the advantages of stably integrating vectors for expression in yeast is that, after the initial cloning and colony isolation, antibiotic maintenance is no longer required. To confirm this, cells were grown with and without G418 and tested for GPI-GM-CSF expression. We have seen no decrease in expression levels in the absence of G418 over 8 months.
  • To produce GPI-GM-CSF on a scale suitable for in vitro and in vivo functional characterization, 500 ml of YPD was inoculated with SC-GM-GPI and grown for three days at 300 with shaking. Cells were pelleted by centrifugation at 12,000×g for 2 minutes at room temperature and transferred to an equal volume of YPG for an additional three days of growth. Cells were then pelleted, washed with TN and lysed in 25 ml of TN containing 20 mM OGP, 1 mM PMSF, and lug/ml each aprotinin, leupeptin and pepstatin. Cells were then lysed by vortexing with acid washed glass beads, 20 g/500 ml culture, (425-600 microns, Sigma). Insoluble material was pelleted at 8,000×g for 10 minutes at room temperature and the soluble material was applied to an immunoaffinity column of anti-murine GMCSF monoclonal antibody (Endogen) linked to cyanogen bromide-activated Sepharose 4B (Sigma). Coupling of the monoclonal to the Sepharose was performed according to the manufacturer's instructions. Efficiency of coupling was monitored using OD280 and binding of murine GM-CSF to immobolized antibody was confirmed using commercially available, recombinant cytokine.
  • Soluble yeast-derived material was applied to the column and allowed to flow by gravity. The column was washed sequentially with: (a) 20 volumes of TN with 1% Triton X-100; (b) 5 volumes of 50 mM Tris pH 8.0, 1 mM OGP; (c) 20 volumes TN with 1 mM OGP. Bound material was then eluted with 10 volumes of 0.15M NaCl, 25 mM Tris pH 2.5 with 1 mM OGP. Eluted material was neutralized with {fraction (1/200)} volume of 1.5M Tris pH8.8. The purified material was concentrated using a Microsep 3K centrifugal device (Pall Gelman Laboratory). Yields of GPI-GM-CSF were determined by ELISA (Endogen) to be 25 ug/L of culture. Final concentration was adjusted to 40 ug/ml by addition of 0.15M NaCl, 25 mM Tris pH 7.4 with 1 mM OGP.
  • Purified GPI-GM-CSF was analyzed by stained gel and western blot. Approximately lug of purified GPI-GM-CSF or recombinant soluble murine GM-CSF per lane were electrophoresed. Gels were then stained with silver nitrate using the Sigma silver staining kit according to the manufacturer's directions (Sigma). For western blots, gels were transferred to Protran BA83 (Schleicher and Schuell) using an Owl Scientific electric transblotter and blocked with TBS (Tris Buffered Saline) containing 0.05% Tween 20 and 2% nonfat dry milk overnight at room temperature. The blot was then incubated with primary antibody (rat monoclonal anti-murine GMCSF, Endogen) at 1:5000 dilution in blocking buffer for 2 hours at room temperature. The blot was washed with TBS-0.05% Tween 20, and incubated with a secondary antibody, alkaline phosphatase conjugated goat anti-rat IgG (Sigma) at 1:10,000 for 1 hour at room temperature. After washing, color was developed with NBT-BCIP (Sigma). A single dominant band migrating at approximately the same rate as a recombinant soluble GM-CSF standard was clearly present on both the gel and the blot (the molecular weight of the GPI moiety is only approximately 1500 compared to approximately 14,000 for the protein moiety]. Given the immunoreactivity with anti-GM-CSF and the ability of this material to bind to tumor cell membranes, these bands appear to represent GPI-GM-CSF. While some high molecular weight material, possibly representing aggregates, is visible in the blot, this material is not visible in the less sensitive silver stain, indicating that it is present in lower amount than the dominant band.
  • Example 3 Attachment of Murine GM-CSF Fused to the Gas1 GPI Modification Signal Sequence to Cells
  • Wild type CMS-5 murine fibrosarcoma cells grown in DMEM, 10% FBS, Pen-Strep were harvested, washed twice with RPMI 1640 (Life Technologies) and resuspended in RPMI 1640 at a concentration of 5×105 cells/ml. 0.9 ml aliquots of the cell suspension were dispensed to Eppendorf siliconized microfuge tubes. Each aliquot received either 1 ug of purified GPI-GM-CSF prepared as in Example 2, 1 ug of soluble recombinant murine GM-CSF (Intergen, supplied as lyophilized powder and reconstituted at 40 ug/ml in the same buffer as GPI-GM-CSF), or media alone. Cells were then incubated for 3 hours at 37° C. with shaking and then washed 3 times with PBS containing 2% FBS.
  • For detection of GPI-GM-CSF by flow cytometry, cells were incubated with a rat anti-murine GM-CSF monoclonal antibody (Endogen) for one hour at 4° C. The cells were then washed 3 times with PBS containing 2% FBS, and incubated with FITC-labeled goat anti-rat IgG antibody (Sigma) for one hour at 4° C., and again washed 3 times with PBS containing 2% FBS. The cells were analyzed by flow cytometry on a Becton-Dickinson Facscalibur. Decoration with GPI-GM-CSF caused an approximately 10-fold increase in peak and mean FL-1 fluorescence relative to cells incubated with media alone. In contrast, cells incubated with soluble GM-CSF had virtually the same profile as the negative control cells. This data indicates that GPI-GM-CSF, but not soluble recombinant GM-CSF, can bind to tumor cells.
  • GPI-GM-CSF attached to CMS-5 cells was also detected and quantitated by ELISA. CMS-5 cells were harvested and washed as described above. 1×106 cells in 1 ml of RPMI 1640 were incubated with 1 ug of purified GPI-GM-CSF. After incubation for 2 hours at 37° C., the cells were washed 3 times with PBS containing 2% FBS. The cell pellet was lysed with 50 microliters of PBS containing 0.15% deoxycholate and the detergent subsequently diluted by the addition of 200 microliters of PBS. The material was serially diluted with PBS and amounts of GM-CSF determined using an ELISA kit (Endogen) against a soluble, recombinant GM-CSF standard provided by the manufacturer. Based on this data, the mean number of GPI-GM-CSF molecules incorporated/cell over five experiments was 37,000+/−33,000. The large standard deviation was due to one experiment in which the number of molecules/cell was 66,000. Excluding this experiment, the mean was 29,500+/−4,500.
  • “Decoration” of B16 murine melanoma cells with GPI-GM-CSF was also quantitated by ELISA. Decoration and ELISA were performed exactly as described for CMS-5 cells. The mean number of molecules/cell over three experiments was 21,000+/−11,500.
  • Example 4 Stability of Murine GM-CSF Fused to the Gas1 GPI Modification Signal Sequence on Cells
  • To study the stability of incorporated GPI-GM-CSF on cells, CMS-5 cells were harvested and decorated as described above in Example 3. After decoration, the cells were washed 3 times with PBS containing 2% FBS and then resuspended at 4×106 cells/ml in RPMI 1640. The cells were irradiated at 3500 rads from a 137CS source. The cells were then incubated at 37° C. in 5% CO2 and aliquots were removed at hourly intervals, washed three times, and lysed in 50 ul PBS with 0.15% deoxycholate. 200 ul of PBS was then added to dilute the deoxycholate. Cell-associated GM-CSF was measured by ELISA. Even at 6 hours, cells showed only about a 20% loss of cell-surface GPI-GM-CSF. After 6 hours, viability of irradiated cells (both decorated and non-decorated) as measured by microscopic inspection with trypan blue staining was significantly compromised. However, in vivo data (see below) indicates that both cell-surface retention of GPI-GM-CSF and post-irradiation cellular viability are sufficient to sustain a biological effect.
  • Example 5 Bioactivity of Murine GM-CSF Fused to the Gas I GPI Modification Signal Sequence to Cells
  • The bioactivity of GPI-GM-CSF was assayed by determining the molecule's ability to support the proliferation of the FDC-P1 cell line, a murine bone-marrow derived, GM-CSF dependent cell line. Proliferation of FDC cells was measured with the Biotrak Cell Proliferation ELISA (Amersham Pharmacia), an assay that utilizes the thymidine analogue 5-bromo-2′-deoxyuridine (BrdU). WEHI cells (ATCC) were grown in Iscove MEM, 10% FBS, Penicillin-streptomycin, as a source of conditioned media for FDC-P1 cells. FDC-P1 cells were grown in DMEM, 10% FBS, Penicillin-streptomycin with 25% WEHI conditioned media, harvested, and washed 3 times with DMEM, 10% FBS, Penicillin-streptomycin. The cells were resuspended at 1×105/ml in DMEM, 10% FBS, Penicillin-streptomycin and 100 uL was aliquoted to individual wells of a 96 well microtitre plate. Groups, done in triplicate, were as follows:
      • A. Media—No Cells
      • B. FDC-P1 Cells-Unstimulated
      • C. FDC-P1 Cells+10 ng soluble GM-CSF
      • D. FDC-P1 Cells+10 ng GM-CSF as GPI-GM-CSF (as determined by ELISA against GM-CSF standard)
      • E. FDC-P1 Cells+10 ng GPI-GM-CSF (as in “D”) denatured by extraction of the protein with chloroform:methanol (3:1) followed by acetone precipitation and resuspension.
        All protein solutions were diluted to 100 ng/ml in 0.15M NaCl, 25 mM Tris pH 7.4 with 1 mM OGP, so that the volume added to each well was 100 uL.
  • The non-isotopic proliferation assay was performed according to the manufacturer's instructions. The plated cells were grown for two days at 37° C. in 5% CO2. On day 3, 10 ul of the BrdU solution was added to individual wells and the cells incubated for 3 more hours. The plate was then centrifuged at 300×g for 10 minutes and the supernatant removed. The plate was dried by incubating at 60° C. for one hour. The plate was then fixed and blocked according to the manufacturer's instructions. The fixed cells were then incubated with peroxidase-labelled anti-BrdU for 90 minutes. The wells were then washed and color developed with TMB according to the manufacturer's instructions. In two experiments, GPI-GM-CSF consistently sustained proliferation at a level somewhat (about 25%) higher than did soluble recombinant GM-CSF, indicating that GPI-GM-CSF is suprabioactive. The effect of GPI-GM-CSF was not due to the GPI moiety alone, since denatured GPI-GM-CSF did not support proliferation. The GPI moiety remained linked to the protein after denaturation, since the protein was still able to decorate cells as demonstrated by ELISA, which recognizes linear epitopes on GM-CSF.
  • Example 6 Effective Immunization with Cells Admixed with GPI-GM-CSF
  • These experiments included mice vaccinated with:
    • (a) Wild-type cells (WT)
    • (b) Cells incubated with soluble GM-CSF—Unwashed (total GM-CSF in dose: 1 microgram)
    • (c) Cells decorated with GPI-GM-CSF—Unbound GPI-GM-CSF Washed off Following Incubation (total GPI-GM-CSF in dose: 0.74 nanograms by ELISA [mean of 2 experiments; 73 and 75 ng individually]
    • (d) Cells decorated with GPI-GM-CSF-Unwashed (total GM-CSF in dose: 1 microgram)
      GPI-GM-CSF mass and concentration values are expressed in terms of equivalence to GM-CSF as determined by ELISA against a soluble GM-CSF standard.
  • CMS-5 cells were grown to 70% confluence in DMEM, 10% FBS, Penicillin-streptomycin, harvested trypsinization, and washed 3 times with RPMI 1640. Viability was determined by trypan blue staining of an aliquot and the cells were then resuspended at a concentration of 4×106 cells/ml a 1 ul aliquots dispensed into siliconized microfuge tubes. The cells were incubated with 1 ug GPI-GM-CSF or 1 ug soluble recombinant murine GM-CSF per 106 cells for 3 hours at 37° C. “Washed” groups were then washed 3 times with PBS, 2% FBS and resuspended at 4×106 cells/ml in RPMI 1640. An aliquot of the washed GPI-GM-CSF decorated cells was removed and the amount of cell-associated GM-CSF measured by ELISA as described above. There were approximately 31,000 and 32,000 GPI-GM-CSF molecules/cell in the washed decorated groups in the two experiments, respectively.
  • The cells were irradiated at 3500 rads from a 137CS source. 8-10 week-old female Balb/c mice (which are syngeneic for CMS-5) were anesthetized by metofane inhalation and vaccinated subcutaneously in the left inguinal fold with 1×106 cells in 0.25 ml. Seven days later, wild-type CMS-5 cells at 70% confluence were harvested and washed 3 times in HBSS. Viability was determined by trypan blue staining of an aliquot and cells were adjusted to 4×106/ml in HBSS. The previously vaccinated mice were then injected subcutaneously behind the neck, under metofane anesthesia, with 2×106 live, wild-type CMS-5 cells in 0.5 ml HBSS.
  • Tumor development was assessed daily by palpation and visual inspection. “Onset” was defined as the first day on which a tumor mass was both palpable and visible. The observer was blinded to the vaccine received by each set of mice to ensure against bias. Mice were sacrificed by CO2 asphyxiation when tumors become unwieldy. Experiments were terminated 70 days after tumor challenge, as planned in advance.
  • Data is pooled from three experiments for GPI-GM-CSF unwashed, soluble GM-CSF, and wild-type vaccine groups. Data for these groups includes that from undepleted controls in a lymphocyte subset depletion experiment. Data for the GPI-GM-CSF washed group is pooled from two experiments, since this group was not included in the initial depletion experiment. The depletion experiment had 4 mice/group, and the other experiments had 5/group. In terms of total mouse numbers, n=14 for GPI-GM-CSF unwashed; 10 for GPI-GM-CSF washed; 14 for soluble GM-CSF unwashed; and 14 for WT. Approximate percentages of mice surviving tumor-free to day 70 after challenge were: WT, 15%; soluble GM-CSF, 50%; GPI-GM-CSF washed, 60%; GPI-GM-CSF unwashed, 85%. Thus, even though the GPI-GM-CSF washed vaccine contained over a thousand-fold less GM-CSF than the unwashed soluble, administration of cells decorated with GPI-GM-CSF was more effective. Furthermore, the GPI-GM-CSF unwashed vaccine, in which some molecules were not attached to a cell, was even more effective.
  • Example 7 Cloning and Expression of Human GM-CSF Fused to the Gas1 GPI Modification Signal Sequence
  • Human GM-CSF is amplified by PCR from a human T cell cDNA library (Clontech) using Pfu polymerase (Stratagene). The following primers are used:
    Upstream
    5′GCGAATCCCGGCCGGCACCCGCCCGCTCGCCCAGCCCC
    Downstream
    5′CAGCCGGCCTCCTGGACTGGCTCCCAGCAGTC
  • The upstream primer contains EcoR1 and Eag1 restriction sites immediately preceding the first amino acid found in the mature human GM-CSF protein. Since expression in S. cerevisiae utilizes a yeast leader sequence, cloning of the human GM-CSF begins at the N terminus of the mature protein. Each downstream primer omits the native stop codon to allow in-frame ligation to the sequence encoding the Gas1 GPI modification signal. The downstream primer contains an NgoM IV restriction site, consistent with restriction sites used in other constructs.
  • PCR parameters are denaturation at 97° C for 1 minute,
      • annealing at 56° C for 1 minute, and
      • extension at 72° C for 2 minutes.
        PCR is performed for the least number of cycles yielding a visible band on agarose gel electrophoresis. After amplification, the reaction mix is allowed to cool at 4° for 10 minutes.
  • The PCR product is isolated by electrophoresis through a 1% agarose gel and eluted from the excised agarose band using a commercially available kit (Qiagen). The purified hGM-CSF DNA fragment is digested with EcoR1 and NgoM IV and ligated to the (murine) pUC19 GM-CSF-GPI plasmid that has been digested with EcoR1 and NgoM IV. This replaces the murine GM-CSF with its human counterpart. The pUC19-hGM-CSF GPI plasmid is then transformed into competent AG-1 E. coli cells, 30 colonies are picked for mini-culture, and plasmid clones are isolated and purified using commercially available kits (Qiagen). Positive clones are identified by restriction enzyme test digest and agarose gel electrophoresis. Positive E. coli colonies are grown overnight in maxi-culture and their plasmids purified using Qiagen maxi-prep kits. Inserts are sequenced.
  • To clone GM-CSF GAS1g into the pITY-4 expression vector, PCR of this construct from the pUC19 vector is performed. The primers are:
    5′TACGGCCGGCACCCGCCCGCTCGCCCAGCCCC
    3′TACGGCCGCCACAATGAAAATAAGATACCAT

    The upstream primer has an EagI site immediately preceding the first codon of the mature GM-CSF. This removes the mammalian secretion signal and allows for in-frame ligation to the yeast signal sequence. The same restriction site can be used as for the mouse construct because it is absent in the human sequence. The downstream primer appends an EagI site at the 3′ end. PCR is performed using Pfu polymerase for 25 cycles. Conditions for PCR are: denaturation 90° one minute, annealing 60° one minute, extension 720 one minute. After amplification, the reaction mix is allowed to cool at 4° for 10 minutes.
  • The PCR product is isolated by electrophoresis through a 1% agarose gel and eluted from the excised agarose band using a commercially available kit (Qiagen). The purified GM-CSF GAS1g DNA fragment is digested with EagI, ligated to pITY-4, and transformed into AG-1 chemically competent bacteria (Stratagene). 30 colonies are picked for mini-culture and plasmid clones are isolated and purified using commercially available kits (Qiagen). Positive clones are identified by restriction enzyme test digest and agarose gel electrophoresis. Positive E. coli colonies are grown overnight in maxi-culture and their plasmids purified using Qiagen maxi-prep kits. Inserts are sequenced.
  • The GPI-human GM-CSF molecule is expressed in S. cerevesiae as described for the murine molecule in Example 2. Immunoaffinity purification is performed as described in Example 2, substituting an anti-human GM-CSF antibody for the anti-murine GM-CSF antibody. ELISA to detect and quantitate the molecule, whether in isolation or bound to an antigen bearing target, is performed using an anti-human GM-CSF monoclonal antibody, as is flow cytometry on cells decorated with the molecule.
  • Example 8 Cloning of GM-CSF/Influenza Hemagglutinin Chimeric Proteins
  • pUC19 GMCSF-K-GAS1.1
  • pUC19 GM-CSF-K-HA was cloned starting with pUC19 GM-CSF-K-Gas1.1, which we produced in our laboratory. This plasmid includes a sequence that encodes murine GM-CSF fused to a downstream glycosylphosphatidylinositol modification sequence derived from the yeast GAS 1 protein (the latter obtained from Dr. D. Wittrup, University of Illinois). A linker sequence is interposed between the GM-CSF and GAS 1 portions. To insert the linker sequence, the plasmid pUC19 GMCSF-Gas1.1, also previously produced in our lab, was digested with NgoM IV and NheI. These restriction enzymes cut at the 3′ end of the GM-CSF molecule and at the 5′ end of the Gas 1.1 sequence, respectively. The resulting plasmid was purified after electrophoresis through agarose gel using a kit manufactured by Qiagen. The following oligonucleotides were purchased:
    5′ CCGGCACTAGTGGCGGAGGGGGCTCCGGCGGCGGGGGCAGCG
    5′ CTAGCGCTGCCCCCGCCGCCGGCGCCCCCTCCGCCACTAGTG

    The synthetic oligonucleotides contain:
      • 1. 5′ overhang that anneals to NgoM IV digested plasmid DNA
      • 2. 3′ overhang that anneals to Nhe I digested plasmid DNA
      • 3. DNA sequence coding for the peptide GGGGSGGGGS where G stands for glycine and S stands for serine. This 10 amino acid sequence (G4S)2 is designed to insert a kink/spacer in the protein between the GMCSF and the Gas 0.1 moieties.
      • 4. SpeI site to allow confirmation of cloning of the small fragment and for further manipulations.
        The two oligonucleotides were mixed in equimolar concentrations, boiled for 2 minutes and allowed to anneal at room temperature. The oligonucelotide was ligated into the NgoM IV-Nhe I digested plasmid and the plasmid was used to transform the E. coli strain AG-1. Transformants were selected on LB plates containing 100 ug/ml ampicillin. Plasmid DNA was isolated, digested with Spe I, and electrophoresed on agarose gels to confirm the presence of the (G4S)2 sequence.
        pUC19 GM-CSF-K-hemagglutinin (HA)
  • The plasmid pUC19 GM-CSF-K-HA was produced, which encodes a chimeric protein containing (from amino terminal to carboxy terminal): (1) murine GM-CSF; (2) the (G4S)2 linker described above; and (3) the HA1 domain of the H1 HA from the A/PR/8/34 influenza A isolate. The HA1 sequence used (amino acids 18 to 344 of the HA precursor) omits the N-terminal leader sequence and the downstream HA2 domain. A termination codon was added after amino acid 344.
  • pUC 19 GM-CSF-K-Gas 1.1. was digested with Nhe I and Kpn L. Nhe I cuts at the 5′ end of the Gas 1.1 coding sequence and Kpn I cuts at the 3′ end of the Gas 1.1 coding sequence, respectively. The resulting plasmid with the GPI coding region removed, was purified after electrophoresis through agarose gel using a kit manufactured by Qiagen. The HA1 coding sequence was cloned by PCR from a plasmid encoding the HA gene of the A/PR/8/34 strain of influenza. The HA1 sequence used begins at amino acid 18, the start of the mature protein, i.e. lacking the secretion signal sequence. The 3′ end corresponds to amino acid 344, eliminating the transmembrane region and substituting a termination codon. Primers for PCR of the HA1 sequence were as follows:
    Upstream HA1 Primer
    5′ ATGCTAGCGACACAATATGTATAGGC
    Downstream HA1 Primer
    5′ ATGGTACCCGGCCGTTATCATCTGGATTGAATGGACGG
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute

    PCR was performed for 20 cycles using vent polymerase.
  • Following PCR, the product was electrophoresed through a 1.0% agarose gel and the HA1 cDNA was extracted from the gel using a Qiagen kit according to the manufacturer's instructions. The purified HA1 DNA fragment was digested with Nhe I and Kpn I. To make the fusion protein, the purified Nhe 1-Kpn I HA fragment was ligated into the pUC 19 GM-CSF-K-Gas1.1 vector that had been digested with Nhe I and Kpn I to remove the Gas1.1 coding region. The DNA was used to transform E. coli AG1 and transformants selected on LB-ampicillin plates. Plasmid DNA from individual colonies was isolated and digested with restriction enzymes. Restriction digests identified a pUC19 GM-CSF-K-HA plasmid.
  • The pUC19 GM-CSF-K-HA plasmid was purified according to the manufacturer's instructions using a kit purchased from Qiagen.
  • Example 9 Cloning of GM-CSF-K-HA into Yeast Expression Vector
  • PCR of pUC19 GM-CSF-K-HA was used to isolate a DNA fragment encoding GM-CSF-K-HA for cloning into a yeast expression vector. The PCR product contains Eag I cloning sites for in frame insertion into the yeast expression vector.
    Upstream Primer
    5′ TACGGCCGGCACCCACCCGCTCACCC
    Downstream Primer
    5′ ATGGTACCCGGCCGTTATCATCTGGATTGAATGGACGG
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute

    PCR was performed for 20 cycles using vent polymerase.
  • Following PCR, the product was electrophoresed through a 1.0% agarose gel and the GM-CSF-K-HA gene was extracted from the gel using a Qiagen kit according to the manufacturers instructions. The purified DNA fragment was digested with Fag I and ligated to the yeast expression vector ITK that had been digested with Eag I. The ITK vector is designed for (1) replication in E. coli and (2) expression of genes in the yeast Saccharomyces cerevisiae after stable integration using homologous recombination. The vector contains:
      • 1. Sequences for replication of the plasmid in E. coli
      • 2. Yeast Gal promoter for expression of heterologous genes in yeast grown in media containing galactose.
      • 3. PrePro—Synthetic DNA sequence, optimized for secretion and signal sequence cleavage of distal genes in yeast.
      • 4. Unique Eag I site for cloning genes to be expressed.
      • 5. Alpha terminator—DNA sequence for efficient termination of proximal genes.
      • 6. Delta sequence that allows for stable integration of the plasmid by recombination with endogenous delta sequences in the yeast chromosome.
      • 7. Antibiotic resistance gene allowing for selection in E. coli with kanamycin and selection in yeast with G418.
  • This plasmid was used to transform E. coli strain AG-1. Transformants were selected by growth on LB plates containing 100 ug/ml kanamycin. Individual colonies were grown in LB media containing kanamycin and plasmids were purified. Restriction digests determined orientation of inserts. The resulting plasmid ITK GM-CSF-K-HA was purified using a kit purchased from Qiagen according to the manufacturer's instructions.
  • Example 10 Expression of GM-CSF-K-HA in Yeast
  • The purified plasmid was linearized with Mfe 1 and used to transform the yeast strain Saccharomyces cerevisiae WDHY131 using lithium acetate (LiAc). A 10 ml culture of S. cerevisiae grown to saturation at 30° in YPD media (per liter/20 g Bactotryptone; 20 g dextrose: 10 g yeast extract) was used to inoculate 100 ml of YPD. The culture was grown at 300 with shaking for 3 hours. The yeast were harvested by centrifugation at 11,000×g for 2 minutes and resuspended in 25 ml of sterile water. The yeast were centrifuged as above and resuspended in 1.0 ml of 100 mM lithium acetate and transferred to a 1.5 ml microfuge tube. The yeast were pelleted by centrifugation at 12,000×g for 15 seconds and the supernatant removed. The cells were resuspended in 0.5 ml of 100 mM LiAc. 50 uL of cell suspension was added to individual microfuge tubes and centrifuged as above. Supernatant was removed.
  • Transformation mix added to the yeast pellet consisted of: 240 uL PEG (50% w/v); 36 uL 1.0 M LiAc; 5 uL single stranded DNA (10 mg/ml) and 1 ug of linearized ITK GM-CSF-K-HA in 75 uL of water. The mixture was vortexed to resuspend the cell pellet and incubated at 30° for 30 minutes. The cells were then shocked at 42° for 15 minutes, centrifuged to pellet cells and resuspended in 0.5 ml of YPD. Yeast were incubated in YPD media for 3 hours and plated on YPD plates containing 2 mg/ml G418. Plates were grown at 30° for 3 days until individual colonies appeared. To screen for expression of GM-CSF-K-HA, individual colonies were grown in 1 ml of YPD media at 300 for 2 days. The cells were centrifuged at 8,000×g for 2 minutes and the YPD media removed and replaced with 1 ml of YPG media (per liter/20 g Bactotryptone; 20 g galactose; 10 g yeast extract) for induction from the gal promoter. Yeast were grown in YPG media for 2 days. At this time, an aliquot was removed and cells were pelleted. The supernatant was tested for GM-CSF expression using an ELISA kit purchased from Endogen. Protocol was according to the manufacturer. A high-expressing yeast clone secreting the chimeric protein GM-CSF-K-HA was identified. Based on standard curve of soluble GMCSF, expression level was approximately 2.4 mg/L of GM-CSF moiety.
  • Example 11 Production of pUC 19 HA (hemagglutinin)-K-GM-CSF
  • The plasmid pUC19 HA-K-GM-CSF was also produced, which encodes a chimeric protein containing (from amino terminal to carboxy terminal): (1) an HA1 domain (2) K, the (G4S)2 linker described above, and (3) murine GM-CSF, The HA1 begins at the amino terminus of the mature protein, amino acid 18, eliminating the leader sequence. The 3′ end terminates at amino acid 344. The (G4S)2 has been added to supply a flexible linker. The GM-CSF begins at amino acid 18 of the GM-CSF protein, corresponding to the first amino acid of the mature protein.
  • The HA-K sequence was first cloned by PCR of the HA1 coding sequence from a plasmid encoding the HA gene of the A/PR/8134 strain of influenza.
    Upstream Primer
    5′ CTGAATTCCGGCCGGACACAATATGTATAGGC
    Downstream Primer
    5′ ATGGTACCGCTGCCCCCGCCGCCGGAGCCCCCTCCGCCACTTCTGGA
    TTGAATGGACGGAAT

    The oligonucleotides for PCR generate a nucleic acid with:
    • 1. A 5′ EcoRI site at the amino terminus of the mature HA
    • 2. The (G4S)2 linker at the carboxy terminus of the HA1 domain (amino acid 344 of the HA precursor)
    • 3. A Kpn I site distal to the end of the (G4S)2 sequence
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute

    PCR was performed for 20 cycles using vent polymerase.
  • Following PCR, the product was electrophoresed through a 1.0% agarose gel and the HA1-K DNA was extracted from the gel using a Qiagen kit according to the manufacturer's instructions. The purified HA-K DNA fragment was digested with EcoRI and Kpn I and the fragment was cloned into pUC19 that had been digested with EcoRI and KpnI. The plasmid was used to transform E. coli AG-1 to ampr. Individual colonies were picked and grown in LB-amp. The identity of plasmids with the correct insert was determined by restriction mapping. The resulting plasmid termed pUC19 HA-K was purified using a Qiagen kit according to the manufacturer's instructions.
    Upstream Primer
    5′ ACGGTACCGCACCCACCCGCTCACCCATC
    Downstream Primer
    5′ TAGGATCCCGGCCGTCATTTTTGGACTGGTTTTTTGCACG

    The PCR primers generate a GM-CSF fragment with
    • 1. 5′ KpnI site that allows in frame translation from the (G4S)2 portion of the HA-K molecule to the start of the mature GM-CSF molecule at amino acid 18.
    • 2. A termination codon at the 3′ end of the GM-CSF
    • 3. 3′ BamHI site
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute

    PCR was performed for 20 cycles using vent polymerase.
  • Following PCR, the product was electrophoresed through a 1.0% agarose gel and the GM-CSF gene was extracted from the gel using a Qiagen kit according to the manufacturer's instructions. The purified fragment was digested with Kpn I and BamHI and the fragment was ligated into pUC19 HA-K plasmid that had been digested with KpnI and BamHI. The plasmid was used to transform E. coli AG-1 to ampr. Individual colonies were picked and grown in LB-amp. The identity of plasmids with the correct insert was determined by restriction mapping. The resulting plasmid termed pUC19 HA-K-GM-CSF was purified using a Qiagen kit according to the manufacturer's instructions.
  • Example 12 Cloning of HA-K-GM-CSF into Yeast Expression Vector
  • PCR of pUC19 HA-K-GM-CSF was used to generate a DNA fragment encoding HA-K-GM-CSF for cloning into a yeast expression vector. The PCR product contains Eag I cloning sites for in-frame insertion into the yeast expression vector.
    Upstream Primer
    5′ CTGAATTCCGGCCGGACACAATATGTATAGGC
    Downstream Primer
    5′ TAGGATCCCGGCCGTCATTTTTGGACTGGTTTTTTGCACG
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute

    PCR was performed for 20 cycles using vent polymerase.
  • Following PCR, the product was electrophoresed through a 1.0% agarose gel and the HA-K-GM-CSF gene was extracted from the gel using a Qiagen kit according to the manufacturers instructions. The purified DNA fragment was digested with Eag I and ligated to the yeast expression vector ITK, that had been digested with Eag I. The ITK vector is designed for (1) replication in E. coli and (2) expression of genes in the yeast Saccharomyces cerevisiae after stable integration using homologous recombination. The vector contains:
      • 1. Sequences for replication of the plasmid in E. coli
      • 2. Yeast Gal promoter for expression of heterologous genes in media containing galactose.
      • 3. PrePro—Synthetic DNA sequence, optimized for secretion and signal sequence cleavage of distal genes in yeast.
      • 4. Unique Eag I site for cloning genes to be expressed.
      • 5. Alpha terminator—DNA sequence for efficient termination of proximal genes.
      • 6. Delta sequence that allows for stable integration of the plasmid by recombination with endogenous delta sequences in the yeast chromosome.
      • 7. Antibiotic resistance gene allowing for selection in E. coli with kanamycin and selection in yeast with G418.
  • This plasmid was used to transform E. coli strain AG-1. Transformants were selected by growth on LB plates containing 100 ug/ml kanamycin. Individual colonies were grown in LB media containing kanamycin and plasmids were purified. Restriction digests determined orientation of inserts. The resulting plasmid ITK HA-K-GM-CSF was purified using a kit purchased from Qiagen according to the manufacturer's instructions.
  • The purified plasmid was linearized with Mfe 1 and used to transform the yeast strain Saccharomyces cerevisiae WDHY131 using lithium acetate (LiAc). A 10 ml culture of S. cerevisiae grown to saturation at 30° C. in YPD media (per liter/20 g Bactotryptone; 20 g dextrose; 10 g yeast extract) was used to inoculate 100 ml of YPD. The culture was grown at 30° C. with shaking for 3 hours. The yeast were harvested by centrifugation at 11,000×g for 2 minutes and resuspended in 25 ml of sterile water. The yeast were centrifuged as above and resuspended in 1.0 ml of 100 mM lithium acetate and transferred to a 1.5 ml microfuge tube. The yeast were pelleted by centrifugation at 12,000×g for 15 seconds and the supernatant removed. The cells were resuspended in 0.5 ml of 100 mM LiAc. 50 uL of cell suspension was added to individual microfuge tubes and centrifuged as above. Supernatant was removed. Transformation mix added to the yeast pellet consisted of: 240 uL PEG (50% w/v); 36 uL 1.0 M LiAc; 5 uL single stranded DNA (10 mg/ml) and 1 ug of linearized ITK HA-K-GM-CSF in 75 uL of water. The mixture was vortexed to resuspend the cell pellet and incubated at 300 for 30 minutes. The cells were then shocked at 42° C. for 15 minutes, centrifuged to pellet cells and resuspended in 0.5 ml of YPD. Yeast were incubated in YPD media for 3 hours and plated on YPD plates containing 2 mg/ml G418. Plates were grown at 30° C. for 3 days until individual colonies appeared. To screen for expression of HA-K-GM-CSF, individual colonies were grown in 1 ml of YPD media at 30° C. for 2 days. The cells were centrifuged at 8,000×g for 2 minutes and the YPD media removed and replaced with 1 ml of YPG media (per liter/20 g Bactotryptone; 20 g galactose; 10 g yeast extract) for induction from the gal promoter. Yeast were grown in YPG media for 2 days. At this time, an aliquot was removed and cells were pelleted. The supernatant was tested for GM-CSF expression using an ELISA kit purchased from Endogen. The protocol was according to the manufacturer.
  • A colony expressing high levels of the chimeric protein was identified. Based on standard curve of soluble GMCSF, expression level is approximately 2.0 mg/L of soluble material. There is no decrease in expression levels in the absence of G418.
  • Example 13 Scale Up Purification of GM-CSF-K-HA
  • For scaled-up purification of the chimeric protein, yeast were inoculated into 500 ml of YPD and grown for three days at 30° C. Cells were pelleted by centrifugation at 12,000×g for 2 minutes and transferred to an equal volume of YPG for an additional three days of growth. The cells were then pelleted by centrifugation at 12,000×g for 2 minutes and the supernatant collected. The soluble material was applied to an immunoaffinity column of anti-murine GMCSF monoclonal antibody (Endogen) linked to cyanogen bromide-activated Sepharose 4B (Sigma). Coupling of the monoclonal to the Sepharose was performed according to the manufacturer. Efficiency of coupling was monitored using OD280 and of binding of GMCSF to immobolized antibody was tested using soluble, commercially available material.
  • Soluble yeast-derived material was applied to the column and allowed to flow by gravity. The column was washed with: (a) 20 volumes of 0.15M NaCl, 25 mM Tris pH 7.4 (TN) (b) 5 volumes of 50 mM Tris pH 8.0 (c) 20 volumes TN. Bound material was then eluted with 10 volumes of 0.15M NaCl, 25 mM Tris pH 2.5. Eluted material was neutralized with 1/200 volume of 1.5M Tris pH8.8. The purified material was concentrated using a Microsep 3K centrifugal devise (Pall Gelman Laboratory). Yields of chimeric protein were determined by ELISA (Endogen) according to the manufacturer's instructions.
  • Purified GM-CSF-K-HA
  • Purified GM-CSF-K-HA was analyzed by western blot. Approximately lug of GM-K-HA per lane was electrophoresed along with soluble GMCSF. For western blot, gels were transferred to Protran BA83 (Schleicher and Schuell), blocked with TBS (Tris Buffered Saline) containing 0.05% Tween 20 and 2% Nonfat Dry Milk. The blot was incubated with primary antibody (rat monoclonal anti-murine GMCSF, Endogen) at 1:5000 dilution in blocking buffer for 2 hours at room temperature. The blot was washed with TBS-0.05% Tween 20. Secondary antibody, alkaline phosphatase conjugated anti-rat IgG (Sigma) was incubated at 1:10,000 for 1 hour at room temperature.
  • Example 14 Decoration of Cells with GM-K-HA
  • Purified GM-CSF-K-HA was used to decorate CMS 5 murine fibrosarcoma cells. CMS 5 cells were grown in DMEM, 10% FBS, Penicillin-streptomycin, harvested by trypsinization and washed 3 times with RPMI 1640 (Gibco). Cells were diluted to 1×106/ml in RPMI 1640 and 0.9 ml were aliquoted to siliconized tubes. Cells were incubated for 2 hours at 37° C. with shaking and then washed 3 times with PBS containing 2% FBS. Primary antibody, rat anti-murine GMCSF monoclonal, was incubated for one hour at 4° C. Cells were washed as above, treated with FITC labeled anti-rat antibody (Sigma), and incubated for one hour at 4° C. After additional washing, the cells were analyzed by flow cytometry, which confirmed the presence of GM-CSF-K-HA on the surface of the tumor cells.
  • Example 15 Quantitation of GM-CSF-K-HA on the Cell Surface of CMS 5 Cells After Decoration
  • CMS 5 cells were harvested and washed as described above. 1×106 cells in 1 ml of RPMI 1640 were incubated with 1 ug of purified GM-K-HA. After incubation for 15 min, 30 min, 1 hour, or 2 hours at 4° C., room temperature, or 37° C., the cells were washed 3 times with PBS containing 2% FBS. The cell pellet was lysed with 50 microliters of PBS containing 0.15% deoxycholate and the detergent subsequently diluted by the addition of 200 microliters of PBS. The material was serially diluted with PBS and tested by ELISA (Endogen). Based on the amount of GM-CSF detected in the cell lysates, it was possible to quantitate the average number of GM-CSF molecules associated with each cell. For example, after a 15 min incubation at 4° C., 58,700 molecules were present per cell. After a 15 min incubation at room temperature, 25,700 molecules were present per cell. After a 15 min incubation at 37° C., 17,200 molecules were present per cell.
  • Example 16 Effective Immunization with Tumor Cells Admixed with GM-CSF/Hemagglutinin Fusion Polypeptides
  • CMS-5 murine fibrosarcoma cells were grown to 70% confluence in DMEM, 10% FBS, Penicillin-streptomycin, harvested by trypsinization, and washed 3 times with RPMI 1640. Viability was determined by trypan blue staining of an aliquot and the cells were then resuspended at a concentration of 4×106 cells/ml and 1 ml aliquots dispensed into siliconized microfuge tubes. The cells were incubated with 1 ug (microgram) murine GM-CSF-K-HA or 10 ng (nanograms) HA-K-murine GM-CSF per 106 cells for 3 hours at 37° C. Cells were then washed 3 times with RPMI 1640 and resuspended at 4×106 cells/ml in RPMI 1640. An aliquot of the cells was removed and the amount of cell-associated GM-CSF measured by ELISA as described above. There were approximately 20,240 and 18,000 molecules/cell in the GM-CSF-K-HA and HA-K-GM-CSF groups, respectively. Cells for a control vaccine, to be administered without a molecule of the invention (or any other immunomodulator), were prepared in parallel.
  • The cells were irradiated at 3500 rads from a 137Cs source. 8 week-old female Balb/c mice (which are syngeneic for CMS-5) were anesthetized by metofane inhalation and vaccinated subcutaneously in the left inguinal fold with 1×106 cells in 0.25 ml. Each mouse received cells from only one vaccine type. Seven days later, wild-type CMS-5 cells at 70% confluence were harvested and washed 3 times in HBSS. Viability was determined by trypan blue staining of an aliquot and cells were adjusted to 4×106/ml in HBSS. The previously vaccinated mice were then injected subcutaneously behind the neck, under metofane anesthesia, with 2×106 live, wild-type CMS-5 cells in 0.5 ml HBSS. The groups receiving the HA-K-GM-CSF and control vaccines each consisted of 5 mice, whereas the group receiving the GM-CSF-K-HA vaccine consisted of 4 mice because 1 mouse failed to awaken from anesthesia.
  • Tumor development was assessed daily by palpation and visual inspection. The observer was blinded to the vaccine received by each set of mice to ensure against bias. Mice were sacrificed by CO2 asphyxiation when tumors become unwieldy. All mice that had received the control vaccine developed tumors within 18 days after challenge with live tumor cells. In contrast, 100% of mice that had received the GM-CSF-K-HA vaccine and 60% of mice that had received the HA-K-GM-CSF vaccine remained tumor-free at the end of the experiment, 40 days after challenge. Thus, immunization with a composition comprising tumor cells and a molecule of the invention confers significantly longer tumor-free survival than immunization with a composition comprising tumor cells but not comprising a molecule of the invention.
  • Example 17 Cloning of Human GM-CSF-K-HA
  • pUC19 human GM-CSF-K-HA (hGM-CSF-K-HA) is cloned starting with pUC19 GM-CSF-K-HA. pUC19 GM-CSF-K-HA. is digested with EcoRI and NgoM IV. EcoRI cuts at the 5′ end of the murine GM-CSF coding sequence and Ngo M IV cuts at the 3′ end of the murine GM-CSF molecule. The resulting plasmid with the murine GM-CSF coding region removed is purified after electrophoresis through agarose gel using a kit manufactured by Qiagen. The human GM-CSF coding segment is generated by PCR from a commercially available human cDNA library (Clontech). The human sequence begins at amino acid 18, the start of the mature protein, i.e. lacking the secretory signal sequence. The 3′ end corresponds to amino acid 144, eliminating the endogenous termination codon.
    Upstream hGM-CSF Primer
    5′ GCGAATTCCGGCCGGCACCCGCCCGCTCGCCCAGC
    Downstream hGM-CSF Primer
    5′ TAGCCGGCCTCCTGGACTGGCTCCCAGCA
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute

    PCR is performed for 20 cycles using vent polymerase.
  • Following PCR, the product is electrophoresed through a 1.0% agarose gel and the hGM-CSF gene is extracted from the gel using a Qiagen kit according to the manufacturer's instructions. The purified hGM-CSF DNA fragment is digested with Eco RI and NgoM IV and ligated into the pUC 19 murine GM-CSF-K-HA vector that has been digested with EcoRI and NgoM IV to remove the murine GM-CSF sequence. The DNA is used to transform E. coli AG1 and transformants are selected on LB-ampicillin plates. Plasmid DNA from individual colonies is isolated and digested with restriction enzymes to identify clone harboring a pUC19 hGM-CSF-K-HA plasmid.
  • The pUC19 hGM-CSF-K-HA plasmid is purified according to the manufacturer's instructions using a kit purchased from Qiagen. PCR of pUC19 hGM-CSF-K-HA is used to generate a DNA fragment encoding hGM-CSF-K-HA for cloning into a yeast expression vector. The PCR product contains Eag I cloning sites for in frame insertion into the yeast expression vector.
    Upstream Primer
    5′ GCGAATTCCGGCCGGCACCCGCCCGCTCGCCCAGC
    Downstream Primer
    5′ ATGGTACCCGGCCGTTATCATCTGGATTGAATGGACGG
  • Conditions for PCR were:
    Denaturation 900 one minute
    Annealing 600 one minute
    Extension 720 one minute

    PCR is performed for 20 cycles using vent polymerase.
  • Following PCR the product is electrophoresed through a 1.0% agarose gel and the hGM-CSF-K-HA gene is extracted from the gel using a Qiagen kit according to the manufacturer's instructions. The purified DNA fragment is digested with Eag I and ligated to the yeast expression vector ITK that has been digested with Eag I. The ITK vector is designed for (1) replication in E. coli and (2) expression of genes in the yeast Saccharomyces cerevisiae after stable integration using homologous recombination. The vector contains:
      • 1. Sequences for replication of the plasmid in E. coli
      • 2. Yeast Gal promoter for expression of heterologous genes in yeast grown in media containing galactose.
      • 3. PrePro—Synthetic DNA sequence, optimized for secretion and signal sequence cleavage of distal genes in yeast.
      • 4. Unique Eag I site for cloning genes to be expressed.
      • 5. Alpha terminator—DNA sequence for efficient termination of proximal genes.
      • 6. Delta sequence that allows for stable integration of the plasmid by recombination with endogenous delta sequences in the yeast chromosome.
      • 7. Antibiotic resistance gene allowing for selection in E. coli with kanamycin and selection in yeast with G418.
  • This plasmid is used to transform E. coli strain AG-1. Transformants are selected by growth on LB plates containing 100 ug/ml kanamycin. Individual colonies are grown in LB media containing kanamycin and plasmids are purified. Restriction digests determine orientation of inserts. The resulting plasmid ITK hGM-CSF-K-HA is purified using a kit purchased from Qiagen according to the manufacturer's instructions.
  • The purified plasmid is linearized with Mfe 1 and used to transform the yeast strain Saccharomyces cerevisiae WDHY131 using lithium acetate (LiAc). A 10 ml culture of S. cerevisiae grown to saturation at 30° in YPD media (per liter/20 g Bactotryptone; 20 g dextrose; 10 g yeast extract) is used to inoculate 100 ml of YPD. The culture is grown at 30° with shaking for 3 hours. The yeast are harvested by centrifugation at 11,000×g for 2 minutes and resuspended in 25 ml of sterile water. The yeast are centrifuged as above and resuspended in 1.0 ml of 100 mM lithium acetate and transferred to a 1.5 ml microfuge tube. The yeast are pelleted by centrifugation at 12,000×g for 15 seconds and the supernatant removed. The cells are resuspended in 0.5 ml of 100 mM LiAc. 50 uL of cell suspension is added to individual microfuge tubes and centrifuged as above. Supernatant is removed. Transformation mix added to the yeast pellet consists of: 240 uL PEG (50% w/v); 36 uL 1.0 M LiAc; 5 uL single stranded DNA (10 mg/ml) and 1 ug of linearized ITK hGM-CSF-K-HA in 75 uL of water. The mixture is vortexed to resuspend the cell pellet and incubated at 30° for 30 minutes. The cells are then shocked at 42° for 15 minutes, centrifuged to pellet, and resuspended in 0.5 ml of YPD. Yeast are incubated in YPD media for 3 hours and plated on YPD plates containing 2 mg/ml G418. Plates are grown at 30° for 3 days until individual colonies appear.
  • To screen for expression of hGM-CSF-K-HA, individual colonies are grown in 1 ml of YPD media at 30° for 2 days. The cells are centrifuged at 8,000×g for 2 minutes and the YPD media removed and replaced with 1 ml of YPG media (per liter/20 g Bactotryptone; 20 g galactose; 10 g yeast extract) for induction from the gal promoter. Yeast are grown in YPG media for 2 day. An aliquot is then removed and the cells are pelleted. The supernatant is tested for hGM-CSF expression using an ELISA kit purchased from Endogen. Protocol is according to the manufacturer.
  • Example 18 Reduction of Metastases in a Mouse Model
  • B16F10 murine melanoma cells were harvested and washed three times in PBS. Cells were then suspended at 5×105 viable cells/ml in PBS, with viability determined by staining an aliquot of cells with Trypan blue. 100 ul of this suspension was injected into the tail veins of 8-10 week old female C57BL/6 mice. On day 1 or day 3 after tumor challenge, mice were immunized with 1×106 irradiated B16F10 cells subcutaneously in the left inguinal fold. Groups (3 mice each) received either cells alone, cells mixed with 1 ug soluble recombinant murine GM-CSF (Serologicals Corp.), or cells mixed with 1 ug of a multifunctional molecule of the invention comprising murine GM-CSF at the N terminus, a (Gly4Ser)2 flexible linker, and the HA1 domain of influenza A/PR/8/34 hemagglutinin at the C terminus. The latter composition comprised both free and cell-bound multifunctional molecule.
  • Mice were sacrificed on day 12, the thoracic cavity opened with dissecting scissors, and the lungs removed en bloc by tracheal transection. Metastases were enumerated with a hand lens. In the mice immunized 1 day after challenge, the average number of metastases/mouse was as follows:
    Cells alone: 30.00
    Cells + GM-CSF: 14.33
    Cells + multifunctional molecule: 0.67
  • In the mice immunized 3 days after challenge, the average number of metastases/mouse was as follows:
    Cells alone: 36.33
    Cells + GM-CSF: 10.33
    Cells + multifunctional molecule: 1.00
  • Thus, administration of the composition comprising a multifunctional molecule of the invention was able to effectively reduce metastases and treat disease.
  • Example 19 GM-CSF-HA1-Mediated Protection Against Tumor Challenge In Vivo
  • As an allogeneic tumor vaccine model, C57BL/6 mice (haplotype b) were immunized with C3H (haplotype k)-derived K1735 melanoma cells, followed by challenge with C57BL/6-derived B16F10 melanoma cells. K1735 cells were grown to 70% confluence in DMEM with 10% FBS and penicillin-streptomycin, harvested by trypsinization, and washed 3 times with RPMI 1640. Viability was determined by trypan blue staining of an aliquot and the cells were then resuspended at a concentration of 4×106 cells/ml for K1735. One ml aliquots were then dispensed into siliconized microfuge tubes. The cells were incubated with 1 ug mGM-CSF-HA1 (a fusion polypeptide consisting of murine GM-CSF at the N terminus, a (Gly4Ser)2 linker, and the HA1 domain of influenza AIPR/8/34) per 106 cells for 2 hours at 4° C. An aliquot of the cells was removed for measurement of cell-associated GM-CSF by ELISA. Mean cell-associated GM-CSF across two experiments was approximately 60,000. Cells that were not admixed with any polypeptide and, in one experiment, cells mixed with 1 ug soluble murine GM-CSF (Serologicals Corp.) were prepared in parallel as control vaccines.
  • The cells were irradiated at 3500 rads from a 137CS source. 8 week-old female C57BL/6 mice were anesthetized by metofane inhalation and vaccinated subcutaneously in the left inguinal fold with or 1×106 cells in 0.25 ml RPMI, along with a total of 1 ug GM-CSF-HA1 (including bound and free fusion polypeptide). Each mouse received cells from only one vaccine type. Seven days later, B16F10 cells, as appropriate, at 70% confluence were harvested and washed 3 times in HBSS. Viability was determined by trypan blue staining of an aliquot and cells were adjusted in HBSS to 1×105/ml. The previously vaccinated mice were then challenged subcutaneously behind the neck, under metofane anesthesia, with 0.5 ml of the B16F10 cell suspension.
  • Tumor development was assessed daily by palpation and visual inspection. “Onset” was defined as the first day on which a tumor mass was both palpable and visible. The observer was blinded to the vaccine received by each set of mice to ensure against bias. Mice were sacrificed by CO2 asphyxiation when tumors become unwieldy. Experiments were terminated 70 days after tumor challenge, as planned in advance.
  • In pooled results from two experiments, 70 days after challenge, 7/10 mice that had been vaccinated with cells admixed with fusion polypeptide remained tumor-free. In contrast, 10/10 mice that had been vaccinated with cells alone developed tumors, as did 4/5 mice vaccinated with cells admixed with soluble murine GM-CSF.
  • Other Embodiments
  • The foregoing examples demonstrate experiments performed and contemplated by the present inventors in making and carrying out the invention. It is believed that these examples include a disclosure of techniques which serve to both apprise the art of the practice of the invention and to demonstrate its usefulness. It will be appreciated by those of skill in the art that the techniques and embodiments disclosed herein are preferred embodiments only that in general numerous equivalent methods and techniques may be employed to achieve the same result.
  • All of the references identified hereinabove, are hereby expressly incorporated herein by reference to the extent that they describe, set forth, provide a basis for or enable compositions and/or methods which may be important to the practice of one or more embodiments of the present inventions.
  • Appendix I
    • 4: BC025704 Homo sapiens, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5, clone MGC:34418 IMAGE:5223581, mRNA, complete cds
      gi|19344005|gb|BC025704.1|[19344005]
    • 5: BC025713 Homo sapiens, T-cell receptor interacting molecule, clone MGC:34314 IMAGE:5227396, mRNA, complete cds
      gi|19343996|gb|BC025713.1|[19343996]
    • 6: BC025722 Homo sapiens, adenosine A2b receptor, clone MGC:34640 IMAGE:5198898, mRNA, complete cds
      gi|19343938|gb|BC025722.1|[19343938]
    • 7: BC025717 Homo sapiens, chemokine (C-C motif) receptor-like 2, clone MGC:34104 IMAGE:5228561, mRNA, complete cds
      gi|19343936|gb|BC025717.1|[19343936]
    • 8: BC025695 Homo sapiens, endothelial differentiation, lysophosphatidic acid
      G-protein-coupled receptor, 4, clone MGC:34227 IMAGE:5209267, mRNA, complete cds
      gi|19343926|gb|BC025695.1|[19343926]
    • 9: BC025727 Homo sapiens, Similar to T cell receptor alpha locus, clone MGC:34712 IMAGE:5201547, mRNA, complete cds
      gi|19343616|gb|BC025727.1|[19343616]
    • 10: BC025691 Homo sapiens, interleukin 2 receptor, beta, clone MGC:34584 IMAGE:5207833, mRNA, complete cds
      gi|19343610|gb|BC025691.1|[19343610]
    • 11: AF474992 Homo sapiens G protein-coupled receptor SNSR6 gene, complete cds
      gi|19338917|gb|AF474992.1|[19338917]
    • 12: AF474991 Homo sapiens G protein-coupled receptor SNSR5 gene, complete cds
      gi|19338915|gb|AF474991.1|[19338915]
    • 13: AF474990 Homo sapiens G protein-coupled receptor SNSR4 gene, complete cds
      gi|19338913|gb|AF474990.1|[19338913]
    • 14: AF474989 Homo sapiens G protein-coupled receptor SNSR3 gene, complete cds
      gi|19338911|gb|AF474989.1|[19338911]
    • 15: AF474988 Homo sapiens G protein-coupled receptor SNSR2 gene, complete cds
      gi|19338909|gb|AF474988.1|[19338909]
    • 71: AF453877 Homo sapiens neuronal nicotinic receptor beta 4 subunit precursor, gene, exon 1 and partial cds
      gi|18042122|gb|AF453877.1|[18042122]
    • 73: U62556 Homo sapiens chemokine receptor-like protein (TER1) gene, complete cds
      gi|1468978|gb|U62556.1|HSU62556[1468978]
    • 74: AF449218 Homo sapiens 43 kDa acetylcholine receptor-associated protein (RAPSN) mRNA, complete cds
      gi|19310212|gb|AF449218.1|[19310212]
    • 84: AJ437349 Homo sapiens partial mRNA for T-cell receptor beta chain (V14-D-J-C) (TCRB gene), clone 11
      gi|19262919|emb|AJ437349.1|HSA437349[19262919]
    • 85: AJ011371 Homo sapiens mRNA for serotonin 4 receptor, splice variant h5-HT4(e)
      gi|3646277|emb|AJ011371.1|HSAJ1371[3646277]
    • 88: BC025294 Homo sapiens, Similar to toll-like receptor 4, clone IMAGE:4868078, mRNA
      gi|19263693|gb|BC025294.1|[19263693]
    • 89: BM875542 ij54d02.y1 Human insulinoma Homo sapiens cDNA clone IMAGE:5634842 5′ similar to TR:O00559 O00559 RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS;, mRNA sequence
      gi|19243208|gb|BM875542.1|BM875542[19243208]
    • 99: AY059419 Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL1) mRNA, KIR3DL1*011 allele, partial cds
      gi|19224338|gb|AY059419.1|[19224338]
    • 100: AY059418 Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL2) mRNA, KIR3DL2*010 allele, partial cds
      gi|19224336|gb|AY059418.1|[19224336]
    • 101: AY059417 Homo sapiens killer-cell immunoglobulin-like receptor KIR3DL1/2v mRNA, partial cds
      gi|19224334|gb|AY059417.1|[19224334]
    • 102: AY059420 Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL2) mRNA, KIR3DL2*012 allele, partial cds
      gi|19224332|gb|AY059420.1|[19224332]
    • 103: AC079385 Homo sapiens 12q BAC RP11-482D24 (Roswell Park Cancer Institute Human BAC Library) complete sequence
      gi|14670063|gb|AC079385.18|[14670063]
    • 104: AC078889 Homo sapiens 12q BAC RP11-33512 (Roswell Park Cancer Institute Human BAC Library) complete sequence
      gi|11072039|gb|AC078889.20|[11072039]
    • 105: AC010168 Homo sapiens 12 p12-31.7-32.2 BAC RP11-174G6 (Rosewell Park Cancer Institute Human Bac Library) complete sequence
      gi|6855156|gb|AC010168.61[6855156]
    • 106: U14188 Homo sapiens LERK-4 (EPLG4) mRNA, complete cds
      gi|642834|gb|U14188.1|HSU14188[642834]
    • 107: U14187 Homo sapiens LERK-3 (EPLG3) mRNA, complete cds
      gi|642832|gb|U14187.1|HSU14187[642832]
    • 108: U15637 Homo sapiens CD40 binding protein (CD40BP) mRNA, complete cds
      gi|595910|gb|U15637.1|HSU15637[595910]
    • 109; AF262304 Homo sapiens clone 6 CC chemokine receptor 3-like mRNA, partial sequence, alternatively spliced
      gi|19171650|gb|AF262304.1|[19171650]
    • 110: AF262303 Homo sapiens clone 6 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171648|gb|AF262303.1|[19171648]
    • 111: AF262302 Homo sapiens clone 5 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171646|gb|AF262302.1|[19171646]
    • 112: AF262301 Homo sapiens clone 4 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171644|gb|AF262301.1|[19171644]
    • 113: AF262300 Homo sapiens clone 2 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171642|gb|AF262300.1|[19171642]
    • 114: AF262299 Homo sapiens clone 1 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171640|gb|AF262299.1|[19171640]
    • 118: AF247361 Homo sapiens CC chemokine receptor 3 (CCR3) gene, complete cds
      gi|19110542|gb|AF247361.1|[19110542]
    • 122: AF416619 Homo sapiens prolactin receptor short isoform 1a (PRLR) mRNA, complete cds, alternatively spliced
      gi|16506717|gb|AF416619.1|[16506717]
    • 123: AF416618 Homo sapiens prolactin receptor short isoform 1b (PRLR) mRNA, complete cds, alternatively spliced
      gi|16506715|gb|AF416618.1|[16506715]
    • 125: AJ303165 Homo sapiens partial gene for putative transmembrane receptor
      gi|13162199|emb|AJ303165.1|HSA303165[13162199]
    • 126: NM017451 Homo sapiens BA11-associated protein 2 (BAIAP2) transcript variant 2, mRNA
      gi|9257198|ref|NM017451.1|[9257198]
    • 127: NM017450 Homo sapiens BA11-associated protein 2 (BAIAP2) transcript variant 1, mRNA
      gi|9257196|ref|NM017450.1|[9257196]
    • 128: NM006340 Homo sapiens BA11-associated protein 2 (BAIAP2) transcript variant 3, mRNA
      gi|5453564|ref|NM006340.1|[5453564]
    • 131: AF350881 Homo sapiens channel kinase 2 (CHAK2) mRNA, complete cds
      gi|18860923|gb|AF350881.2|[18860923]
    • 132: AF022044 Homo sapiens natural killer cell receptor KIR3D51 variant mRNA, complete cds
      gi|2760894|gb|AF022044.1|[2760894]
    • 133: AF034773 Homo sapiens natural killer cell inhibitory receptor (KIR2DL4) mRNA, variant 3, complete cds
      gi|2739181|gb|AF034773.1|[2739181]
    • 134: AF034772 Homo sapiens natural killer cell inhibitory receptor (KIR2DL4) mRNA, variant 2, complete cds
      gi|2739179|gb|AF034772.1|[2739179]
    • 135: AF034771 Homo sapiens natural killer cell inhibitory receptor (KIR2DL4) mRNA, variant 1, complete cds
      gi|2739177|gb|AF034771.1|[2739177]
    • 136: AF022047 Homo sapiens natural killer cell inhibitory receptor KIR2D53 variant mRNA, complete cds
      gi|2738966|gb|AF022047.1|[2738966]
    • 137: AF022046 Homo sapiens natural killer cell inhibitory receptor KIR2D51 variant mRNA, complete cds
      gi|2738964|gb|AF022046.1|[2738964]
    • 138: AF022045 Homo sapiens natural killer cell receptor KIR2DL1 variant mRNA, complete cds
      gi|2738962|gb|AF022045.1|[2738962]
    • 139: U56255 Homo sapiens CW-1 mRNA, complete cds
      gi|1399688|gb|U56255.1|HSU56255[1399688]
    • 140: AJ422056 Homo sapiens partial GRM5 gene for metabotrophic glutamate receptor, exon 1A
      gi|19069804|emb|AJ422056.1|HSA422056[19069804]
    • 141: AY028912 Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 7 and complete cds, alternatively spliced
      gi|19067944|gb|AY028912.1|AY028906S7[19067944]
    • 142: AY028911 Homo sapiens ectodysplasin A receptor associated death domain (ED.hD)T ene, exon 6
      gi|19067943|gb|AY028911.1|AY028906S6[19067943]
    • 143: AY028910 Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 5
      gi|19067942|gb|AY028910.1|AY028906S5[19067942]
    • 144: AY028909 Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 4
      gi|19067941|gb|AY028909.1|AY028906S4[19067941]
    • 145: AY028908 Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 3
      gi|19067940|gb|AY028908.1|AY028906S3[19067940]
    • 146: AY028907 Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 2
      gi|19067939|gb|AY028907.1|AY028906S2[19067939]
    • 147: AY028906 Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 1
      gi|9067938|gb|AY028906.1|AY028906S1[19067938]
    • 148: AH010677 Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, complete cds, alternatively spliced
      gi|19067937|gb|AH010677.1|SEG_AY028906S[19067937]
    • 149: AY028913 Homo sapiens ectodysplasia A receptor associated death domain A (EDARADD) mRNA, complete cds; alternatively spliced
      gi|19067935|gb|AY028913.1|[19067935]
    • 150: BM735809 06E08 Canine Brain cDNA Library Canis familiaris cDNA 5′ similar to Homo sapiens glycine receptor, beta, mRNA sequence
      gi|19057142|gb|BM735809.1|BM735809[19057142]
    • 151: BM735756 06A09 Canine Brain cDNA Library Canis familiaris cDNA 5′ similar to Homo sapiens glycine receptor, beta subunit, mRNA sequence
      gi|19057089|gb|BM735756.1|BM735756[19057089]
    • 152: BM735711 10E11 Canine Brain cDNA Library Canis familiaris cDNA 5′ similar to Homo sapiens protein tyrosine phosphatase, receptor-type, Z polypeptide 1, mRNA sequence
      gi|19057044|gb|BM735711.1|BM735711[19057044]
    • 155: AC007165 Homo sapiens BAC clone RP11-451C2 from 2, complete sequence
      gi|19033999|gb|AC007165.4|[19033999]
    • 156: AF245699 Homo sapiens type 1 angiotensin II receptor (AGTR1) gene, complete cds
      gi|7862074|gb|AF245699.1|[7862074]
    • 157: BC024229 Homo sapiens, prostaglandin E receptor 3 (subtype EP3), clone MGC:27302 IMAGE:4660371, mRNA, complete cds
      gi|18999476|gb|BC024229.1|[18999476]
    • 176: AJ417555 Homo sapiens partial mRNA for killer cell immunoglobulin receptor (KIR2D54 gene), strain 4053
      gi|18958228|emb|AJ417555.1|HSA417555[18958228]
    • 177: AJ417554 Homo sapiens partial mRNA for killer cell immunoglobulin receptor (KIR2D54 gene), strain 3321
      gi|18958226|emb|AJ417554.1|HSA417554[18958226]
    • 179: NM003877 Homo sapiens STAT induced STAT inhibitor-2 (STAT12), mRNA
      gi|18921206|ref|NM003877.2|[18921206]
    • 180: NM017662 Homo sapiens transient receptor potential cation channel, subfamily M, member 6(TRPM6), mRNA
      gi|18921092|ref|NM017662.3|[18921092]
    • 191: NM016148 Homo sapiens SH3 and multiple ankyrin repeat domains 1 (SHANK1), mRNA
      gi|11968151|ref|NM016148.1|[11968151]
    • 193: NM017729 Homo sapiens epidermal growth factor receptor pathway substrate 8 related protein 1 (EPS8R1), mRNA
      gi|8923231|ref|NM017729.1|[8923231]
    • 195: M13824 Homo sapiens T cell receptor gamma chain variable region (TCRG) gene, partial cds
      gi|339169|gb|M13824.1|HUMTCGXL[339169]
    • 196: M12960 Homo sapiens T-cell receptor gamma-chain J1, partial cds
      gi|339144|gb|M12960.1|HUMTCGJB[339144]
    • 197: M13823 Homo sapiens T cell receptor gamma chain (TCRG) gene, partial cds
      gi|292736|gb|M13823.1|HUMTCGXK[292736]
    • 198: L12398 Homo sapiens dopamine receptor D4 (DRD4) mRNA, complete cds
      gi|291945|gb|L12398.1|HUMD4C[291945]
    • 199: M86383 Homo sapiens nicotinic acetylcholine receptor alpha 3 subunit precursor, mRNA, complete cds
      gi|177897|gb|M86383.1|HUMA3NARSP[177897]
    • 202: NM012245 Homo sapiens SKI-interacting protein (SNW1), mRNA
      gi|18860912|ref|NM012245.2|[18860912]
    • 203: NM006750 Homo sapiens syntrophin, beta 2 (dystrophin-associated protein A1, 59 kD, basiccomponent 2) (SNTB2), transcript variant 1, mRNA
      gi|18860911|ref|NM006750.2|[18860911]
    • 204: NM130845 Homo sapiens syntrophin, beta 2 (dystrophin-associated protein A1, 59 kD, basic component 2) (SNTB2), transcript variant 2, mRNA
      gi|18860909|ref|NM130845.1|[18860909]
    • 205: NM002846 Homo sapiens protein tyrosine phosphatase, receptor type, N (PTPRN), mRNA
      gi|18860905|ref|NM002846.2|[18860905]
    • 206: NM002845 Homo sapiens protein tyrosine phosphatase, receptor type, M (PTPRM), mRNA
      gi|18860903|ref|NM002845.2|[18860903]
    • 207: NM002844 Homo sapiens protein tyrosine phosphatase, receptor type, K (PTPRK), mRNA
      gi|18860901|ref|NM002844.2|[18860901]
    • 208: NM002843 Homo sapiens protein tyrosine phosphatase, receptor type, J (PTPRJ), mRNA
      gi|18860899|ref|NM002843.2|[18860899]
    • 209: NM002841 Homo sapiens protein tyrosine phosphatase, receptor type, G (PTPRG), mRNA
      gi|18860897|ref|NM002841.2|[18860897]
    • 210: NM130440 Homo sapiens protein tyrosine phosphatase, receptor type, F (PTPRF), transcript variant 2, mRNA
      gi|18860895|ref|NM130440.1|[18860895]
    • 211: NM130393 Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant 4, mRNA
      gi|18860893|ref|NM130393.1|[18860893]
    • 212: NM130392 Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant 3, mRNA
      gi|18860891|ref|NM130392.1|[18860891]
    • 213: NM130391 Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant 2, mRNA
      gi|18860889|ref|NM130391.1|[18860889]
    • 214: NM003682 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 4, mRNA
      gi|18860876|ref|NM003682.2|[18860876]
    • 215: NM130476 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 8, mRNA
      gi|18860874|ref|NM130476.1|[18860874]
    • 216: NM130475 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 7,
      mRNA
      gi|18860872|ref|NM130475.1|[18860872]
    • 217: NM002840 Homo sapiens protein tyrosine phosphatase, receptor type, F (PTPRF), transcript variant 1, mRNA
      gi|18860871|ref|NM002840.2|[18860871]
    • 218: NM130474 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 6, mRNA
      gi|18860869|ref|NM130474.1|[18860869]
    • 219: NM130473 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 5, mRNA
      gi|18860867|ref|NM130473.1|[18860867]
    • 220: NM130472 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 3, mRNA
      gi|18860865|ref|NM130472.1|[18860865]
    • 221: NM130471 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 2, mRNA
      gi|18860863|ref|NM130471.1|[18860863]
    • 222: NM130470 Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 1, mRNA
      gi|18860861|ref|NM130470.1|[18860861]
    • 223: NM006504 Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 1, mRNA
      gi|18860861|ref|NM006504.2|[18860860]
    • 224: NM130435 Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 2, mRNA
      gi|18860858|ref|NM130435.1|[18860858]
    • 225: AJ431177 Homo sapiens mRNA for WIRE protein
      gi|18857713|emb|AJ431177.1|HSA431177[18857713]
    • 226: NM006474 Homo sapiens lung type-I cell membrane-associated glycoprotein (T1A-2), mRNA
      gi|18767663|ref|NM006474.2|[18767663]
    • 228: NM006794 Homo sapiens G protein-coupled receptor 75 (GPR75), mRNA
      gi|5803024|ref|NM006794.1|[5803024]
    • 229: NM002842 Homo sapiens protein tyrosine phosphatase, receptor type, H (PTPRH), mRNA
      gi|4506312|ref|NM002842.1|[4506312]
    • 230: NM002839 Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant 1, mRNA
      gi|4506308|ref|NM002839.1|[4506308]
    • 231: BC024145 Homo sapiens, TNF receptor-associated factor 1, clone MGC:10353 IMAGE:3832475, mRNA, complete cds
      gi|18848176|gb|BC024145.1|[18848176]
    • 232: AF469756 Homo sapiens clone S9 interleukin-1 receptor type I (IL1R1) gene, partial sequence
      gi|18846656|gb|AF469756.1|[18846656]
    • 233: AF469755 Homo sapiens clone S8 interleukin-1 receptor type I (IL1R1) gene, partial sequence
      gi|18846655|gb|AF469755.1|[18846655]
    • 234: AF469754 Homo sapiens clone S7 interleukin-1 receptor type I (IL1R1) gene, partial
      sequence
      gi|18845036|gb|AF469754.1|[18845036]
    • 237: AF416711 Homo sapiens Fc-gamma receptor IIc5 mRNA, partial cds
      gi|18765992|gb|AF416711.1|[18765992]
    • 238: NM023068 Homo sapiens sialoadhesin (SN), mRNA
      gi|18765743|ref|NM023068.2|[18765743]
    • 239: NM004782 Homo sapiens synaptosomal-associated protein, 29 kD (SNAP29), mRNA
      gi|18765736|ref|NM004782.2|[18765736]
    • 240: NM130798 Homo sapiens synaptosomal-associated protein, 23 kD (SNAP23), transcript variant 2, mRNA
      gi|18765730|ref|NM130798.1|[18765730]
    • 241: NM003825 Homo sapiens synaptosomal-associated protein, 23 kD (SNAP23), transcript variant 1, mRNA
      gi|18765728|ref|NM003825.2|[18765728]
    • 245: AF439409 Homo sapiens G-protein-coupled receptor kinase 7 (GRK7) mRNA, GRK7-S allele, complete cds
      gi|17933258|gb|AF439409.1|[17933258]
    • 246: NM032211 Homo sapiens lysyl oxidase-like 4 (LOXL4), mRNA
      gi|16933522|ref|NM032211.4|[16933522]
    • 247: AF411122 Homo sapiens importin 4 mRNA, complete cds
      gi|18700634|gb|AF411122.1|[18700634]
    • 289: NM130441 Homo sapiens C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11 (CLECSF11), mRNA
      gi|18466805|ref|NM130441.1|[18466805]
    • 290: NM030876 Homo sapiens olfactory receptor, family 5, subfamily V, member 1 (OR5V1), mRNA
      gi|14495550|ref|NM030876.2|[14495550]
    • 291: NM032732 Homo sapiens hypothetical protein MGC10763 (IL17RL), mRNA
      gi|14249349|ref|NM032732.1|[14249349]
    • 292: NM030959 Homo sapiens olfactory receptor, family 12, subfamily D, member 3 (OR12D3), mRNA
      gi|13624334|ref|NM030959.1|[13624334]
    • 294: NM018844 Homo sapiens B-cell receptor-associated protein BAP29 (BAP29), mRNA
      gi|9994198|ref|NM018844.1|[9994198]
    • 295: NM002825 Homo sapiens pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) (PTN), mRNA
      gi|18656935|ref|NM002825.2|[18656935]
    • 299: NM016372 Homo sapiens seven transmembrane domain orphan receptor (TPRA40), mRNA
      gi|7705964|ref|NM016372.1|[7705964]
    • 300: NM014288 Homo sapiens integrin beta 3 binding protein (beta3-endonexin) (ITGB3BP), mRNA
      gi|7657205|ref|NM014288.1|[7657205]
    • 301: L43588 Homo sapiens T cell antigen receptor mRNA, partial cds
      gi|18654191|gb|L43588.1|HUMTCARF[18654191]
    • 318: U77589 Homo sapiens MHC class II HLA-DQ-alpha chain (HLA-DQA1) mRNA, HLA-DQA1*0104 allele, complete cds
      gi|1916744|gb|U77589.1|HSU77589[1916744]
    • 319: AF410465 Homo sapiens importin 9 mRNA, complete cds
      gi|15529702|gb|AF410465.1|[15529702]
    • 320: AF332759 Homo sapiens partially duplicated CHRNA7 gene, hybrid intron A/4 and partial exon 5
      gi|13345792|gb|AF332759.1|[13345792]
    • 321: AF332758 Homo sapiens alpha-7 nicotinic cholinergic receptor subunit (CHRNA7) gene, partial intron 4 and partial cds
      gi|13345790|gb|AF332758.1|[13345790]
    • 322: NM003744 Homo sapiens numb homolog (Drosophila) (NUMB), mRNA
      gi|18644887|ref|NM003744.2|[18644887]
    • 323: NM003681 Homo sapiens pyridoxal (pyridoxine, vitamin B6) kinase (PDXK), mRNA
      gi|18644884|ref|NM003681.2|[18644884]
    • 324: NM080706 Homo sapiens transient receptor potential cation channel, subfamily V, member 1(TRPV1), transcript variant 3, mRNA
      gi|18375670|ref|NM080706.1|[18375670]
    • 325: NM080705 Homo sapiens transient receptor potential cation channel, subfamily V, member 1(TRPV1), transcript variant 4, mRNA
      gi|18375668|ref|NM080705.1|[18375668]
    • 326: NM080704 Homo sapiens transient receptor potential cation channel, subfamily V, member 1(TRPV1), transcript variant 1, mRNA
      gi|18375666|ref|NM080704.1|[18375666]
    • 327: NM018727 Homo sapiens transient receptor potential cation channel, subfamily V, member 1(TRPV1), transcript variant 2, mRNA
      gi|18375664|ref|NM018727.3|[18375664]
    • 328: NM080819
      Homo sapiens G protein-coupled receptor 78 (GPR78), mRNA
      gi|18201873|ref|NM080819.1|[18201873]
    • 329: NM080738
      Homo sapiens EDAR-associated death domain (EDARADD), mRNA
      gi|18152768|ref|NM080738.1|[18152768]
    • 330: NM080491 Homo sapiens GRB2-associated binding protein 2 (GAB2), transcript variant 1, mRNA
      gi|18105041|ref|NM080491.1|[18105041]
    • 331: NM012296 Homo sapiens GRB2-associated binding protein 2 (GAB2), transcript variant 2, mRNA
      gi|18105040|ref|NM012296.2|[18105040]
    • 332: NM032027 Homo sapiens beta-amyloid binding protein precursor (BBP), mRNA
      gi|17738309|ref|NM032027.2|[17738309]
    • 333: NM057159 Homo sapiens endothelial differentiation, lysophosphatidic acid
      G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA
      gi|16950637|ref|NM057159.1|[16950637]
    • 334: NM001401 Homo sapiens endothelial differentiation, lysophosphatidic acid
      G-protein-coupled receptor, 2 (EDG2), transcript variant 1, mRNA
      gi|16950635|ref|NM001401.2|[16950635]
    • 335: NM007070 Homo sapiens FKBP-associated protein (FAP48), transcript variant 2, mRNA
      gi|16933538|ref|NM007070.2|[16933538]
    • 336: NM053274 Homo sapiens FKBP-associated protein (FAP48), transcript variant 1, mRNA
      gi|16933536|ref|NM053274.1|[16933536]
    • 337: NM003726 Homo sapiens src family associated phosphoprotein 1 (SCAP1), mRNA
      gi|16753209|ref|NM003726.2|[16753209]
    • 338: NM033632 Homo sapiens F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) (FBXW7), transcript variant 1, mRNA
      gi|16117780|ref|NM033632.1|[16117780]
    • 339: NM018315 Homo sapiens F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) (FBXW7), transcript variant 2, mRNA
      gi|16117778|ref|NM018315.2|[16117778]
    • 340: NM021203 Homo sapiens APMCF1 protein (APMCF1), mRNA
      gi|14917112|ref|NM021203.2|[14917112]
    • 341: NM002927 Homo sapiens regulator of G-protein signalling 13 (RGS13), mRNA
      gi|14589857|ref|NM002927.2|[14589857]
    • 344: NM020167 Homo sapiens neuromedin U receptor 2 (NMU2R), mRNA
      gi|9910461|ref|NM020167.1|[9910461]
    • 346: AF190052 Homo sapiens interleukin 1 receptor type I (IL1R1) gene, exon 1C sequence
      gi|9719300|gb|AF190052.1|[9719300]
    • 347: NM018965 Homo sapiens triggering receptor expressed on myeloid cells 2 (TREM2), mRNA
      gi|9507202|ref|NM018965.1|[9507202]
    • 348: NM018643 Homo sapiens triggering receptor expressed on myeloid cells 1 (TREM1), mRNA
      gi|8924261|ref|NM018643.1|[8924261]
    • 349: NM018647 Homo sapiens tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), mRNA
      gi|8924251|ref|NM018647.1|[8924251]
    • 350: NM018695 Homo sapiens erbb2 interacting protein (ERBB2IP), mRNA
      gi|8923908|ref|NM018695.1|[8923908]
    • 351: NM017636 Homo sapiens transient receptor potential cation channel, subfamily M, member 4(TRPM4), mRNA
      gi|8923048|ref|NM017636.1|[8923048]
    • 353: NM016559 Homo sapiens PXR2b protein (PXR2b), mRNA
      gi|7706670|ref|NM016559.1|[7706670]
    • 354: NM016382 Homo sapiens natural killer cell receptor 2B4 (CD244), mRNA
      gi|7706528|ref|NM016382.1|[7706528]
    • 357: NM015986 Homo sapiens cytokine receptor-like factor 3 (CRLF3), mRNA
      gi|7705331|ref|NM015986.1|[7705331]
    • 358: NM014815 Homo sapiens KIAA0130 gene product (KIAA0130), mRNA
      gi|7661929|ref|NM014815.1|[7661929]
    • 359: NM014053 Homo sapiens FLVCR protein (FLVCR), mRNA
      gi|7661707|ref|NM014053.1|[7661707]
    • 360: NM014478 Homo sapiens calcitonin gene-related peptide-receptor component protein
      (CGRP-RCP), mRNA
      gi|7656976|ref|NM014478.1|[7656976]
    • 361: NM012470 Homo sapiens transportin-SR (TRN-SR), mRNA
      gi|6912733|ref|NM012470.1|[6912733]
    • 362: NM007357 Homo sapiens low density lipoprotein receptor defect C complementing (LDLC), mRNA
      gi|6678675|ref|NM007357.1|[6678675]
    • 366: NM005162 Homo sapiens angiotensin receptor-like 2 (AGTRL2), mRNA
      gi|6031157|ref|NM005162.2|[6031157]
    • 367: NM005501 Homo sapiens integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b, mRNA
      gi|6006010|ref|NM005501.1|[6006010]
    • 370: NM007053 Homo sapiens natural killer cell receptor, immunoglobulin superfamily member (BY55), mRNA
      gi|5901909|ref|NM007053.1|[5901909]
    • 371: NM006653 Homo sapiens suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor) (SNT-2), mRNA
      gi|5730058|ref|NM006653.1|[5730058]
    • 374: NM005761 Homo sapiens plexin C1 (PLXNC1), mRNA
      gi|5032222|ref|NM005761.1|[5032222]
    • 375: NM005866 Homo sapiens sigma receptor (SR31747 binding protein 1) (SR-BP1), mRNA
      gi|5032116|ref|NM005866.1|[5032116]
    • 377: NM005506 Homo sapiens CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II) (CD36L2), mRNA
      gi|5031630|ref|NM005506.1|[5031630]
    • 379: NM004799 Homo sapiens MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor (MADHIP), transcript variant 3, mRNA
      gi|4759059|ref|NM004799.1|[4759059]
    • 380: NM004292 Homo sapiens ras inhibitor (RIN1), mRNA
      gi|4759039|ref|NM004292.1|[4759039]
    • 381: NM004828 Homo sapiens lymphocyte antigen 95 (activating NK-receptor; NK-p44) (LY95), mRNA
      gi|4758693|ref|NM004828.1|[4758693]
    • 382: NM004767 Homo sapiens endothelin type b receptor-like protein 2 (ET(B)R-LP-2), mRNA
      gi|4758309|ref|NM004767.1|[4758309]
    • 383: NM004440 Homo sapiens EphA7 (EPHA7), mRNA
      gi|4758281|ref|NM004440.1|[4758281]
    • 384: NM003999 Homo sapiens oncostatin M receptor (OSMR), mRNA
      gi|4557039|ref|NM003999.1|[4557039]
    • 386: NM003305 Homo sapiens transient receptor potential cation channel, subfamily C, member 3(TRPC3), mRNA
      gi|4507686|ref|NM003305.1|[4507686]
    • 388: NM003626 Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (PPFIA1), mRNA
      gi|4505982|ref|NM003626.1|[4505982]
    • 389: NM003876 Homo sapiens putative receptor protein (PMI), mRNA
      gi|4505900|ref|NM003876.1|[4505900]
    • 390: NM003559 Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type II, beta (PIP5K2B), mRNA
      gi|4505818|ref|NM003559.1|[4505818]
    • 391: NM003629 Homo sapiens phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3), mRNA
      gi|4505804|ref|NM003629.1|[4505804]
    • 392: NM003676 Homo sapiens degenerative spermatocyte homolog, lipid desaturase (Drosophila) (DEGS), mRNA
      gi|4505192|ref|NM003676.1|[4505192]
    • 393: NM002270 Homo sapiens karyopherin (importin) beta 2 (KPNB2), mRNA
      gi|4504906|ref|NM002270.1|[4504906]
    • 394: NM002204 Homo sapiens integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant a, mRNA
      gi|4504746|ref|NM002204.1|[4504746]
    • 395: NM001560 Homo sapiens interleukin 13 receptor, alpha 1 (IL13RA1), mRNA
      gi|4504646|ref|NM001560.1|[4504646]
    • 396: NM000842 Homo sapiens glutamate receptor, metabotropic 5 (GRM5), mRNA
      gi|4504142|ref|NM000842.1|[4504142]
    • 397: NM001883 Homo sapiens corticotropin releasing hormone receptor 2 (CRHR2), mRNA
      gi|4503044|ref|NM001883.1|[4503044]
    • 398: NM001873 Homo sapiens carboxypeptidase E (CPE), mRNA
      gi|4503008|ref|NM001873.1|[4503008]
    • 400: L29395 Homo sapiens v-erbB-related protein gene, partial cds
      gi|459807|gb|L29395.1|HUMERBB[459807]
    • 401: L08584 Homo sapiens T cell receptor beta chain (TCRB) mRNA, partial cds
      gi|307497|gb|L08584.1|HUMTCVB7A[307497]
    • 403: NM015638 Homo sapiens chromosome 20 open reading frame 188 (C20orf188), mRNA
      gi|18158415|ref|NM015638.1|[18158415]
    • 405: NM054032 Homo sapiens G protein-coupled receptor MRGX4 (MRGX4), mRNA
      gi|16876454|ref|NM054032.1|[16876454]
    • 406: NM054031 Homo sapiens G protein-coupled receptor MRGX3 (MRGX3), mRNA
      gi|16876452|ref|NM054031.1|[16876452]
    • 407: NM054030 Homo sapiens G protein-coupled receptor MRGX2 (MRGX2), mRNA
      gi|16876450|ref|NM054030.1|[16876450]
    • 408: NM052931 Homo sapiens activating NK receptor (KALI), mRNA
      gi|16418406|ref|NM052931.1|[16418406]
    • 409: NM032871 Homo sapiens tumor necrosis factor receptor superfamily, member 19-like (TNFRSF19L), mRNA
      gi|14249611|ref|NM032871.1|[14249611]
    • 410: NM032553 Homo sapiens putative purinergic receptor (FKSG79), mRNA
      gi|14211848|ref|NM032553.1|[14211848]
    • 411: NM025179 Homo sapiens plexin A2 (PLXNA2), mRNA
      gi|13378152|ref|NM025179.1|[13378152]
    • 413: NM021249 Homo sapiens sorting nexin 6 (SNX6), mRNA
      gi|13027619|ref|NM021249.1|[13027619]
    • 414: NM014045 Homo sapiens DKFZP564C1940 protein (DKFZP564C1940), mRNA
      gi|13027587|ref|NM014045.1|[13027587]
    • 415: NM080923 Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 4, mRNA
      gi|18641365|ref|NM080923.1|[18641365]
    • 416: NM080922 Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 3, mRNA
      gi|18641363|ref|NM080922.1|[18641363]
    • 417: NM080921 Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 2, mRNA
      gi|18641361|ref|NM080921.1|[18641361]
    • 418: NM130386 Homo sapiens collectin sub-family member 12 (COLEC12), transcript variant I, mRNA
      gi|18641359|ref|NM130386.1|[18641359]
    • 419: NM030781 Homo sapiens collectin sub-family member 12 (COLEC12), transcript variant II, mRNA
      gi|18641357|ref|NM030781.2|[18641357]
    • 420: NM002838 Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1, mRNA
      gi|18641346|ref|NM002838.2|[18641346]
    • 421: NM130770 Homo sapiens 5-hydroxytryptamine receptor 3 subunit C (HTR3C), mRNA gi|18640739|ref|NM130770.1|[18640739]
    • 430: BD010218 Novel hemopoietin receptor protein, NR12
      gi|18638591|dbj|BD010218.1|[18638591]
    • 431: BD010217 Novel hemopoietin receptor protein, NR12
      gi|18638590|dbj|BD010217.1|[18638590]
    • 432: BD010216 Novel hemopoietin receptor protein, NR12
      gi|18638589|dbj|BD010216.1|[18638589]
    • 433: BD010215 Novel hemopoietin receptor protein, NR12
      gi|18638588|dbj|BD010215.1|[18638588]
    • 434: BD010214 Novel hemopoietin receptor protein, NR12
      gi|18638587|dbj|BD010214.1|[18638587]
    • 435: BD010125 Peptide leukotriene receptor
      gi|18638498|dbj|BD010125.1|[18638498]
    • 436: BD010114 Novel receptor and gene encoding the same
      gi|18638487|dbj|BD010114.1|[18638487]
    • 437: BD010057 Novel G protein coupled receptor protein and its DNA
      gi|18638430|dbj|BD010057.1|[18638430]
    • 438: BD010056 Novel G protein coupled receptor protein and its DNA
      gi|18638429|dbj|BD010056.1|[18638429]
    • 439: BD010055 Novel G protein coupled receptor protein and its DNA
      gi|18638428|dbj|BD010055.1|[18638428]
    • 440: BD010054 Novel G protein coupled receptor protein and its DNA
      gi|18638427|dbj|BD010054.1|[18638427]
    • 441: BD010053 Novel G protein coupled receptor protein and its DNA
      gi|18638426|dbj|BD010053.1|[18638426]
    • 442: BD010052 Novel G protein coupled receptor protein and its DNA
      gi|18638425|dbj|BD010052.1|[18638425]
    • 443: BD010051 Novel G protein coupled receptor protein and its DNA
      gi|18638424|dbj|BD010051.1|[18638424]
    • 444: BD010050 Novel G protein coupled receptor protein and its DNA
      gi|18638423|dbj|BD010050.1[18638423]
    • 445: BD010049 Novel G protein coupled receptor protein and its DNA
      gi|18638422|dbj|BD010049.1|[18638422]
    • 446: BD010046 Novel G protein coupled receptor protein and its DNA
      gi|18638419|dbj|BD010046.1|[18638419]
    • 447: BD010035 Novel G protein coupled receptor protein and its DNA
      gi|18638408|dbj|BD010035.1|[18638408]
    • 448: BD010034 Novel G protein coupled receptor protein and its DNA
      gi|18638407|dbj|BD010034.1|[18638407]
    • 449: BD010028 Novel G protein coupled receptor protein and its DNA
      gi|18638401|dbj|BD010028.1|[18638401]
    • 450: BD010022 Novel G protein coupled receptor protein and its DNA
      gi|18638395|dbj|BD010022.1|[18638395]
    • 451: BD009263 GABAA receptor subunit epsilon-related protein
      gi|18637636|dbj|BD009263.1|[18637636]
    • 452: BD009262 GABAA receptor subunit epsilon-related protein
      gi|18637635|dbj|BD009262.1|[18637635]
    • 453: BD009261 GABAA receptor subunit epsilon-related protein
      gi|18637634|dbj|BD009261.1|[18637634]
    • 454: BD009260 GABAA receptor subunit epsilon-related protein
      gi|18637633|dbj|BD009260.1|[18637633]
    • 455: BD006753 Human G protein chemokine receptor HDGNR10
      gi|18635124|dbj|BD006753.1|[18635124]
    • 460: E51301 Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein
      gi|18633577|dbj|E51301.1|[18633577]
    • 461: E51300 Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein
      gi|18633576|dbj|E51300.1|[18633576]
    • 462: E51299 Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein gi|18633575|dbj|E51299.1|[18633575]
    • 463: E51298 Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein gi|18633574|dbj|E51298.1|[18633574]
    • 464: E51297 Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein gi|18633573|dbj|E51297.1|[18633573]
    • 465: E51296 Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein gi|18633572|dbj|E51296.1|[18633572]
    • 466: E50838 Novel G protein-coupled receptor
      gi|18633543|dbj|E50838.1|[18633543]
    • 467: E50837 Novel G protein-coupled receptor
      gi|18633542|dbj|E50837.1|[18633542]
    • 468: E50836 Novel G protein-coupled receptor
      gi|18633541|dbj|E50836.1|[18633541]
    • 469: E50835 Novel G protein-coupled receptor
      gi|18633540|dbj|E50835.1|[18633540]
    • 470: E50834 Novel G protein-coupled receptor
      gi|18633539|dbj|E50834.1|[18633539]
    • 471: E50833 Novel G protein-coupled receptor
      gi|18633538|dbj|E50833.1|[18633538]
    • 490: BD003056 Novel G protein-coupled receptor protein and DNA thereof
      gi|18631017|dbj|BD003056.1|[18631017]
    • 491: E55122 Novel G protein-coupled receptor and the G protein-coupled receptor gene gb|18629753|dbj|E55122.1|[18629753]
    • 492: E55121 Novel G protein-coupled receptor and the G protein-coupled receptor gene gi|18629752|dbj|E55121.1|[18629752]
    • 493: E55120 Novel G protein-coupled receptor and the G protein-coupled receptor gene gi|18629751|dbj|E55120.1|[18629751]
    • 494: E55119 Novel G protein-coupled receptor and the G protein-coupled receptor gene gi|18629750|dbj|E55119.1|[18629750]
    • 495: E55118 Novel G protein-coupled receptor and the G protein-coupled receptor gene gi|18629749|dbj|E55118.1|[18629749]
    • 496: E55117 Novel G protein-coupled receptor and the G protein-coupled receptor gene gi|18629748|dbj|E55117.1|[18629748]
    • 497: E49128 Novel G protein-conjugated receptor protein
      gi|18629265|dbj|E49128.1|[18629265]
    • 498: E49127 Novel G protein-conjugated receptor protein
      gi|18629264|dbj|E49127.1|[18629264]
    • 499: E49126 Novel G protein-conjugated receptor protein
      gi|18629263|dbj|E49126.1|[18629263]
    • 500: E49125 Novel G protein-conjugated receptor protein
      gi|18629262|dbj|E49125.1|[18629262]
    • 501: D21847
      Human mRNA for T cell receptor alpha chain TcHST2Va7, V segment, J segment and C region
      gi|431140|dbj|D21847.1|HUMTCHST24[431140]
    • 502: D21846
      Human mRNA for T cell receptor beta chain HPBL3xVb20, V segment, D segment, J segment and C region
      gi|431139|dbj|D21846.1|HUMHPBL3X3[431139]
    • 503: D21845
      Human mRNA for T cell receptor alpha chain HPBL3xVa7, V segment, J segment and C region
      gi|431138|dbj|D521845.1|HUMHPBL3X2[431138]
    • 504: D21844
      Human mRNA for T cell receptor alpha chain HPBL(−)Va7, V segment, J segment and
      C region
      gi|431137|dbj|D521844.1|HUMCHPBL1[431137]
    • 505: D13083
      Human mRNA for T-cell receptor beta-chain V region, partial cds, clone WBDM19C
      gi|407766|dbj|D13083.1|HUMVB73B[407766]
    • 506: D13085
      Human mRNA for T-cell receptor beta-chain V region, partial cds, clone WBDM28A
      gi|407764|dbj|D513085.1|HUMVB69B[407764]
    • 507: D13088
      Human TCRBV2.3a mRNA for T-cell receptor beta-chain V region, partial cds
      gi|407762|dbj|D13088.1|HUMVB23A[407762]
    • 508: D13087
      Human TCRBV2.1c mRNA for T-cell receptor beta-chain V region, partial cds
      gi|407760|dbj|D13087.1|HUMVB21C[407760]
    • 509: D13082
      Human mRNA for T-cell receptor beta-chain V region, partial cds, clone WBDM17A
      gi|407758|dbj|D13082.1|HUMVB21AA[407758]
    • 510: D13086
      Human TCRBV20.1a mRNA for T-cell receptor beta-chain V region, partial cds
      gi|407756|dbj|D13086.1HUMVB201A[407756]
    • 511: D13084
      Human TCRBV12.5a mRNA for T-cell receptor beta-chain V region, partial cds
      gi|407754|dbj|D513084.1|HUMVB125A[407754]
    • 512: D13073
      Human TCRAVN1 mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407752|dbj|D13073.1|HUMVAN1[407752]
    • 513: D13079
      Human TCRAV8.1a mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407750|dbj|D13079.1|HUMVA81A[407750]
    • 514: D13069
      Human TCRAV5.1a mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407748|dbj|D13069.1HUMVA51A[407748]
    • 515: D13078
      Human TCRAV2.5a mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407746|dbj|D13078.1|HUMVA25A[407746]
    • 516: D13072
      Human mRNA for T-cell receptor alpha-chain V-J-C, partial cds, clone WADM13D
      gi|407744|dbj|D13072.1|HUMVA221AJ[407744]
    • 517: D13076
      Human TCRAV21.1a mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407742|dbj|D13076.1|HUMVA211A[407742]
    • 518: D13071
      Human mRNA for T-cell receptor alpha-chain V region, partial cds, clone WADM11H
      gi|407740|dbj|D13071.1|HUMVA171A[407740]
    • 519: D13074
      Human TCRAV14.1a mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407738|dbj|D13074.1|HUMVA141A[407738]
    • 520: D13070
      Human TCRAV1.3a mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407736|dbj|D13070.1|HUMVA13A[407736]
    • 521: D13077
      Human TCRAV1.2a mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407734|dbj|D13077.1|HUMVA12A[407734]
    • 522: D13075
      Human TCRAV10.1a mRNA for T-cell receptor alpha-chain V region, partial cds
      gi|407732|dbj|D13075.1|HUMVA101A[407732]
    • 523: D13081
      Human mRNA for T-cell receptor alpha-chain J segment, partial cds, clone WADM36G
      gi|407730|dbj|D13081.1|HUMJAAC17[407730]
    • 524: D13080
      Human mRNA for T-cell receptor alpha-chain J segment, partial cds, clone WADM36A
      gi|407728|dbj|D13080.1|HUMJAAB19[407728]
    • 525: D16584
      Homo sapiens mRNA for T cell receptor beta chain, N-terminal
      gi|391732|dbj|D16584.1|HUMTCRB17[391732]
    • 526: D16586
      Homo sapiens mRNA for T cell receptor alpha chain, N-terminal
      gi|391731|dbj|D16586.1|HUMTCRB17[391731]
    • 527: D16585
      Homo sapiens mRNA for T cell receptor alpha chain, N-terminal
      gi|391730|dbj|D16585.1|HUMTCRA32[391730]
    • 528: NM003268
      Homo sapiens toll-like receptor 5 (TLR5), mRNA
      gi|19718736|ref|NM003268.3|[19718736]
    • 529: NM003265
      Homo sapiens toll-like receptor 3 (TLR3), mRNA
      gi|19718735|ref|NM003265.2|[19718735]
    • 530: NM003264
      Homo sapiens toll-like receptor 2 (TLR2), mRNA
      gi|19718733|ref|NM003264.2|[19718733]
    • 531: NM003263
      Homo sapiens toll-like receptor 1 (TLR1), mRNA
      gi|19718732|ref|NM003263.2|[19718732]
    • 534: NM020350
      Homo sapiens angiotensin II, type I receptor-associated protein (ATRAP), mRNA
      gi|19705427|ref|NM020350.2|[19705427]
    • 535: AY081843
      Homo sapiens GnRH receptor II 5TM mRNA, complete cds
      gi|19697895|gb|AY081843.1|[19697895]
    • 539: NM016511
      Homo sapiens C-type lectin-like receptor-1 (LOC51267), mRNA
      gi|7706062|ref|NM016511.1|[7706062]
    • 540: NM016509
      Homo sapiens C-type lectin-like receptor-2 (LOC51266), mRNA
      gi|7706060|ref|NM016509.1|[7706060]
    • 546: AL713657
      Homo sapiens mRNA; cDNA DKFZp547G1215 (from clone DKFZp547G1215)
      gi|19584339|emb|AL713657.1|HSM802985[19584339]
    • 547: AJ438313
      Homo sapiens partial mRNA for KIT protein
      gi|19571549|emb|AJ438313.1|HSA438313[19571549]
    • 575: AF390036
      Homo sapiens FCRLd mRNA, partial cds
      gi|16611715|gb|AF390036.1|[16611715]
    • 576: AF329495
      Homo sapiens FCRLe mRNA, complete cds
      gi|16506270|gb|AF329495.1|[16506270]
    • 577: AF329494
      Homo sapiens FCRLc1 mRNA, complete cds
      gi|16506268|gb|AF329494.1|[16506268]
    • 578: AF329493
      Homo sapiens FCRLb mRNA, complete cds
      gi|16506266|gb|AF329493.1|[16506266]
    • 579: AF329491
      Homo sapiens FCRLc2 mRNA, complete cds
      gi|16506262|gb|AF329491.1|[16506262]
    • 580: AF329489
      Homo sapiens FCRLa mRNA, complete cds
      gi|16506258|gb|AF329489.1|[16506258]
    • 582: AB060695
      Homo sapiens TLR5 mRNA for Toll-like receptor 5, complete cds
      gi|13810567|dbj|AB060695.1|[13810567]
    • 583: AJ276429
      Homo sapiens mRNA for 19A protein
      gi|12619176|emb|AJ276429.2|HSA276429[12619176]
    • 584: AL136801
      Homo sapiens mRNA; cDNA DKFZp434K0220 (from clone DKFZp434K0220); complete cds
      gi|12053114|emb|AL136801.1|HSM801769[12053114]
    • 585: AL136652
      Homo sapiens mRNA; cDNA DKFZp56401762 (from clone DKFZp56401762); complete cds
      gi|12052829|emb|AL136652.1|HSM801622[12052829]
    • 587: AB012911
      Homo sapiens mRNA for Frizzled-6, complete cds
      gi|3062802|dbj|AB012911.1|[3062802]
    • 589: AY071862
      Homo sapiens crinkled (CR) mRNA, complete cds
      gi|19568064|gb|AY071862.1|[19568064]
    • 596: NM133169
      Homo sapiens osteoclast-associated receptor (OSCAR), transcript variant 2, mRNA
      gi|19557667|ref|NM133169.1|[19557667]
    • 597: NM133168
      Homo sapiens osteoclast-associated receptor (OSCAR), transcript variant 3, mRNA
      gi|19557663|ref|NM133168.1|[19557663]
    • 598: NM130771
      Homo sapiens osteoclast-associated receptor (OSCAR), transcript variant 1, mRNA
      gi|19557659|ref|NM130771.1|[19557659]
    • 599: AF426461
      Homo sapiens FREB mRNA, complete cds
      gi|18056674|gb|AF426461.1|[18056674]
    • 600: AF428134
      Homo sapiens T-cell receptor beta-chain (TCRVb13.1-Jb1.5) mRNA, partial cds
      gi|16566700|gb|AF428134.1|[16566700]
    • 601: AF428133
      Homo sapiens T-cell receptor beta-chain (TCRVb13.1-Jb1.2) mRNA, partial cds
      gi|16566697|gb|AF428133.1|[16566697]
    • 602: AF428132
      Homo sapiens T-cell receptor beta-chain (TCRVb8.1-Jb2.3) mRNA, partial cds
      gi|16566694|gb|AF428132.1|[16566694]
    • 603: AF428131
      Homo sapiens T-cell receptor beta-chain (TCRVb8.2-Jb2.7) mRNA, partial cds
      gi|16566691|gb|AF428131.1|[16566691]
    • 604: AF428130
      Homo sapiens T-cell receptor beta-chain (TCRVb8.1-Jb2.3) mRNA, partial cds
      gi|16566688|gb|AF428130.1|[16566688]
    • 605: AF428129
      Homo sapiens T-cell receptor beta-chain (TCRVb7.1-Jb1.2) mRNA, partial cds
      gi|16566685|gb|AF428129.1|[16566685]
    • 606: AF428128
      Homo sapiens T-cell receptor beta-chain (TCRVb7.2-Jb1.6) mRNA, partial cds
      gi|16566682|gb|AF428128.1|[16566682]
    • 607: AF428127
      Homo sapiens T-cell receptor beta-chain (TCRVb7.1-Jb1.2) mRNA, partial cds
      gi|16566679|gb|AF428127.1|[16566679]
    • 608: AF428126
      Homo sapiens T-cell receptor beta-chain (TCRVb7.2-Jb1.2) mRNA, partial cds
      gi|16566676|gb|AF428126.1|[16566676]
    • 609: AF428125
      Homo sapiens T-cell receptor beta-chain (TCRVb7.1-Jb1.5) mRNA, partial cds
      gi|16566673|gb|AF428125.1|[16566673]
    • 611: AF242456
      Homo sapiens interleukin 13 receptor alpha 1-binding protein-1 mRNA, complete cds
      gi|19548138|gb|AF242456.1|[19548138]
    • 616: S57283
      Homo sapiens endothelin ET-B receptor mRNA, complete cds
      gi|298321|gb|S57283.1|[298321]
    • 617: L14854
      Homo sapiens T cell receptor TCR-beta D38 (TCRB) mRNA, partial cds
      gi|292794|gb|L14854.1|HUMTCRD38[292794]
    • 618: NM024080
      Homo sapiens transient receptor potential cation channel, subfamily M, member 8
      (TRPM8), mRNA
      gi|13129071|ref|NM024080.1|[13129071]
    • 619: AY069961
      Homo sapiens lymphocyte effector toxicity activation ligand (LETAL) mRNA, complete cds
      gi|19525539|gb|AY069961.1|[19525539]
    • 620: U43901
      Homo sapiens 37 kD laminin receptor precursor/p40 ribosome associated protein (LAMR1) gene, complete cds; and E2 small nuclear RNA gene, complete sequence
      gi|19483807|gb|U43901.2|HSU43901[19483807]
    • 621: NM021044
      Homo sapiens desert hedgehog homolog (Drosophila) (DHH), mRNA
      gi|19482157|ref|NM021044.1|[19482157]
    • 622: AC078860
      Homo sapiens 12q BAC RP11-186F10 (Roswell Park Cancer Institute Human BAC Library) complete sequence
      gi|13491193|gb|AC078860.19|[13491193]
    • 623: AC003683
      Homo sapiens x BAC RP1-147H15 (Roswell Park Cancer Institute Human BAC Library)
      complete sequence
      gi|13489135|gb|AC003683.2|[13489135]
    • 624: AC007397
      Homo sapiens 12 p13 BAC RPCI11-439G16 (Roswell Park Cancer Institute Human BAC Library) complete sequence
      gi|5685879|gb|AC007397.21|[5685879]
    • 625: AC007784
      Homo sapiens 12 p13 BAC RPCI11-1092P21 (Roswell Park Cancer Library Human BAC Library) complete sequence
      gi|5597031|gb|AC007784.7|[5597031]
    • 627: AF451730
      Homo sapiens isolate R5255 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401669|gb|AF451730.1|[19401669]
    • 628: AF451729
      Homo sapiens isolate Q5252 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401667|gb|AF451729.1|[19401667]
    • 629: AF451728
      Homo sapiens isolate P5739 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401665|gb|AF451728.1|[19401665]
    • 630: AF451727
      Homo sapiens isolate P5742 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401663|gb|AF451727.1|[19401663]
    • 631: AF451726
      Homo sapiens isolate P5738 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401661|gb|AF451726.1|[19401661]
    • 632: AF451725
      Homo sapiens isolate 0581 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401658|gb|AF451725.1|[19401658]
    • 633: AF451724
      Homo sapiens isolate N505 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401656|gb|AF451724.1|[19401656]
    • 634: AF451723
      Homo sapiens isolate N504 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401653|gb|AF451723.1|[19401653]
    • 635: AF451722
      Homo sapiens isolate P5729 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401650|gb|AF451722.1|[19401650]
    • 636: AF451721
      Homo sapiens isolate P5728 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401647|gb|AF451721.1|[19401647]
    • 637: AF451720
      Homo sapiens isolate 0268 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401645|gb|AF451720.1|[19401645]
    • 638: AF451719
      Homo sapiens isolate 038 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401642|gb|AF451719.1|[19401642]
    • 639: AF451718
      Homo sapiens isolate 037 T cell receptor delta chain (TRD@) mRNA, partial cds
      gi|19401640|gb|AF451718.1|[19401640]
    • 640: AF449218
      Homo sapiens 43 kDa acetylcholine receptor-associated protein (RAPSN) mRNA, complete cds
      gi|19310212|gb|AF449218.1|[19310212]
    • 644: BC025704
      Homo sapiens, leukocyte immunoglobulin-like receptor, subfamily B (with TM and
      ITIM domains), member 5, clone MGC:34418 IMAGE:5223581, mRNA, complete cds
      gi|19344005|gb|BC025704.1|[19344005]
    • 645: BC025713
      Homo sapiens, T-cell receptor interacting molecule, clone MGC:34314 IMAGE:5227396, mRNA, complete cds
      gi|19343996|gb|BC025713.1|[19343996]
    • 646: BC025722
      Homo sapiens, adenosine A2b receptor, clone MGC:34640 IMAGE:5198898, mRNA, complete cds
      gi|19343938|gb|BC025722.1|[19343938]
    • 647: BC025717
      Homo sapiens, chemokine (C-C motif) receptor-like 2, clone MGC:34104 IMAGE:5228561, mRNA, complete cds
      gi|19343936|gb|BC025717.1|[19343936]
    • 648: BC025695
      Homo sapiens, endothelial differentiation, lysophosphatidic acid
      G-protein-coupled receptor, 4, clone MGC:34227 IMAGE:5209267, mRNA, complete cds
      gi|19343926|gb|BC025695.1|[19343926]
    • 650: BC025691
      Homo sapiens, interleukin 2 receptor, beta, clone MGC:34584 IMAGE:5207833, mRNA,
      complete cds
      gi|19343610|gb|BC025691.1|[19343610]
    • 651: AF474992
      Homo sapiens G protein-coupled receptor SNSR6 gene, complete cds
      gi|19338917|gb|AF474992.1|[19338917]
    • 652: AF474991
      Homo sapiens G protein-coupled receptor SNSR5 gene, complete cds
      gi|19338915|gb|AF474991.1|[19338915]
    • 653: AF474990
      Homo sapiens G protein-coupled receptor SNSR4 gene, complete cds
      gi|19338913|gb|AF474990.1|[19338913]
    • 654: AF474989
      Homo sapiens G protein-coupled receptor SNSR3 gene, complete cds
      gi|19338911|gb|AF474989.1|[19338911]
    • 655: AF474988
      Homo sapiens G protein-coupled receptor SNSR2 gene, complete cds
      gi|19338909|gb|AF474988.1|[19338909]
    • 656: AF474987
      Homo sapiens G protein-coupled receptor SNSR1 gene, complete cds
      gi|19338907|gb|AF474987.1|[19338907]
    • 695: AF453877
      Homo sapiens neuronal nicotinic receptor beta 4 subunit precursor, gene, exon 1
      and partial cds
      gi|18042122|gb|AF453877.1|[18042122]
    • 697: U62556
      Homo sapiens chemokine receptor-like protein (TER1) gene, complete cds
      gi|1468978|gb|U62556.1|HSU62556[1468978]
    • 698: AJ011371
      Homo sapiens mRNA for serotonin 4 receptor, splice variant h5-HT4(e)
      gi|3646277|emb|AJ011371.1|HSAJ1371[3646277]
    • 712: AY059419
      Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL1) mRNA, KIR3DL1*011 allele, partial cds
      gi|19224338|gb|AY059419.1|[19224338]
    • 713: AY059418
      Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL2) mRNA, KIR3DL2*010 allele, partial cds
      gi|19224336|gb|AY059418.1|[19224336]
    • 714: AY059417
      Homo sapiens killer-cell immunoglobulin-like receptor KIR3DL1/2v mRNA, partial
      cds
      gi|19224334|gb|AY059417.1|[19224334]
    • 715: AY059420
      Homo sapiens killer-cell immunoglobulin-like receptor (KIR3DL2) mRNA, KIR3DL2*012 allele, partial cds
      gi|19224332|gb|AY059420.1|[19224332]
    • 716: AC079385
      Homo sapiens 12q BAC RP11-482D24 (Roswell Park Cancer Institute Human BAC Library) complete sequence
      gi|14670063|gb|AC079385.18|[14670063]
    • 717: AC078889
      Homo sapiens 12q BAC RP11-335112 (Roswell Park Cancer Institute Human BAC Library) complete sequence
      gi|11072039|gb|AC078889.20|[11072039]
    • 718: AC010168
      Homo sapiens 12 p12-31.7-32.2 BAC RP11-174G6 (Rosewell Park Cancer Institute Human Bac Library) complete sequence
      gi|6855156|gb|AC010168.6|[6855156]
    • 719: U14188
      Homo sapiens LERK-4 (EPLG4) mRNA, complete cds
      gi|642834|gb|U14188.1|HSU14188[642834]
    • 720: U14187
      Homo sapiens LERK-3 (EPLG3) mRNA, complete cds
      gi|642832|gb|U14187.1|HSU14187[642832]
    • 721: U15637
      Homo sapiens CD40 binding protein (CD40BP) mRNA, complete cds
      gi|595910 gb|U15637.1|HSU15637[595910]
    • 722: AF262304
      Homo sapiens clone 7 CC chemokine receptor 3-like mRNA, partial sequence, alternatively spliced
      gi|19171650|gb|AF262304.1|[19171650]
    • 723: AF262303
      Homo sapiens clone 6 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171648|gb|AF262303.1|[19171648]
    • 724: AF262302
      Homo sapiens clone 5 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171646|gb|AF262302.1|[19171646]
    • 725: AF262301
      Homo sapiens clone 4 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171644|gb|AF262301.1|[19171644]
    • 726: AF262300
      Homo sapiens clone 2 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171642|gb|AF262300.1|[19171642]
    • 727: AF262299
      Homo sapiens clone 1 CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|19171640|gb|AF262299.1|[19171640]
    • 729: AF247361
      Homo sapiens CC chemokine receptor 3 (CCR3) gene, complete cds
      gi|19110542|gb|AF247361.1|[19110542]
    • 730: AF247360
      Homo sapiens CC chemokine receptor 3 (CCR3) gene, promoter region and partial sequence
      gi|1911054|gb|AF247360.1|[19110541]
    • 731: AF247359
      Homo sapiens CC chemokine receptor 3 (CCR3) gene, promoter region and partial sequence
      gi|19110540|gb|AF247359.1|[19110540]
    • 733: AF416619
      Homo sapiens prolactin receptor short isoform 1a (PRLR) mRNA, complete cds, alternatively spliced
      gi|16506717|gb|AF416619.1|[16506717]
    • 734: AF416618
      Homo sapiens prolactin receptor short isoform 1b (PRLR) mRNA, complete cds, alternatively spliced
      gi|16506715|gb|AF416618.1[16506715]
    • 736: AJ303165
      Homo sapiens partial gene for putative transmembrane receptor
      gi|13162199|emb|AJ303165.1|HSA303165[13162199]
    • 738: AF350881
      Homo sapiens channel kinase 2 (CHAK2) mRNA, complete cds
      gi|18860923|gb|AF350881.2|[18860923]
    • 739: AF022044
      Homo sapiens natural killer cell receptor KIR3D51 variant mRNA, complete cds
      gi|2760894|gb|AF022044.1|[2760894]
    • 740: AF034773
      Homo sapiens natural killer cell inhibitory receptor (KIR2DL4) mRNA, variant 3, complete cds
      gi|2739181|gb|AF034773.1|[2739181]
    • 741: AF034772
      Homo sapiens natural killer cell inhibitory receptor (KIR2DL4) mRNA, variant 2,
      complete cds
      gi|2739179|gb|AF034772.1([2739179]
    • 742: AF034771
      Homo sapiens natural killer cell inhibitory receptor (KIR2DL4) mRNA, variant 1, complete cds
      gi|2739177|gb|AF034771.1|[2739177]
    • 743: AF022047
      Homo sapiens natural killer cell inhibitory receptor KIR2D53 variant mRNA, complete cds
      gi|2738966|gb|AF022047.1|[2738966]
    • 744: AF022046
      Homo sapiens natural killer cell inhibitory receptor KIR2D51 variant mRNA, complete cds
      gi|2738964|gb|AF022046.1|[2738964]
    • 745: AF022045
      Homo sapiens natural killer cell receptor KIR2DL1 variant mRNA, complete cds
      gi|2738962|gb|AF022045.1|[2738962]
    • 746: U56255
      Homo sapiens CW-1 mRNA, complete cds
      gi|1399688|gb|U56255.1|HSU56255[1399688]
    • 747: AJ422056
      Homo sapiens partial GRM5 gene for metabotrophic glutamate receptor, exon 1A
      gi|19069804|emb|AJ422056.1|HSA422056[19069804]
    • 748: AY028912
      Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 7 and complete cds, alternatively spliced
      gi|19067944|gb|AY028912.1|AY028906S7[19067944]
    • 749: AY028911
      Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 6
      gi|19067943|gb|AY028911.1|AY028906S6[19067943]
    • 750: AY028910
      Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 5
      gi|19067942|gb|AY028910.1|AY028906S5[19067942]
    • 751: AY028909
      Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 4
      gi|1906794|gb|AY028909.1|AY028906S4[19067941]
    • 752: AY028908
      Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 3
      gi|19067940|gb|AY028908.1|AY028906S3[19067940]
    • 753: AY028907
      Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 2
      gi|19067939|gb|AY028907.1|AY028906S2[19067939]
    • 754: AY028906
      Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, exon 1
      gi|19067938|gb|AY028906.1|AY028906S1[19067938]
    • 755: AH010677
      Homo sapiens ectodysplasin A receptor associated death domain (EDARADD) gene, complete cds, alternatively spliced
      gi|19067937|gb|AH010677.1|SEG_AY028906S[19067937]
    • 756: AY028913
      Homo sapiens ectodysplasia A receptor associated death domain A (EDARADD) mRNA,
      complete cds; alternatively spliced
      gi|9067935|gb|AY028913.1|[19067935]
    • 757: BM735809
      06E08 Canine Brain cDNA Library Canis familiaris cDNA 5′ similar to Homo sapiens
      glycine receptor, beta, mRNA sequence
      gi|19057142|gb|BM735809.1|BM735809[19057142]
    • 758: BM735756
      06A09 Canine Brain cDNA Library Canis familiaris cDNA 5; similar to Homo sapiens
      glycine receptor, beta subunit, mRNA sequence
      gi|19057089|gb|BM735756.1|BM735756[19057089]
    • 759: BM735711
      10E11 Canine Brain cDNA Library Canis familiaris cDNA 5′ similar to Homo sapiens
      protein tyrosine phosphatase, receptor-type, Z polypeptide 1, mRNA sequence
      gi|19057044|gb|BM735711.1|BM735711[19057044]
    • 762: AC007165
      Homo sapiens BAC clone RP11-451C2 from 2, complete sequence
      gi|19033999|gb|AC007165.4|[19033999]
    • 763: AF245699
      Homo sapiens type 1 angiotensin II receptor (AGTR1) gene, complete cds
      gi|7862074|gb|AF245699.1|[7862074]
    • 764: BC024229
      Homo sapiens, prostaglandin E receptor 3 (subtype EP3), clone MGC:27302 IMAGE:4660371, mRNA, complete cds
      gi|18999476|gb|BC024229.1|[18999476]
    • 783: AJ417555
      Homo sapiens partial mRNA for killer cell immunoglobulin receptor (KIR2D54 gene), strain 4053
      gi|18958228|emb|AJ417555.1|HSA417555[18958228]
    • 784: AJ417554
      Homo sapiens partial mRNA for killer cell immunoglobulin receptor (KIR2D54 gene), strain 3321
      gi|18958226|emb|AJ417554.1|HSA417554[18958226]
    • 786: NM003877
      Homo sapiens STAT induced STAT inhibitor-2 (STAT12), mRNA
      gi|18921206|ref|NM003877.2|[18921206]
    • 787: NM017662
      Homo sapiens transient receptor potential cation channel, subfamily M, member 6
      (TRPM6), mRNA
      gi|18921092|ref|NM017662.3|[18921092]
    • 788: NM133181
      Homo sapiens epidermal growth factor receptor pathway substrate 8 related protein 3 (EPS8R3), mRNA
      gi|18874727|ref|NM133181.1|[18874727]
    • 802: M13823
      Homo sapiens T cell receptor gamma chain (TCRG) gene, partial cds
      gi|292736|gb|M13823.1|HUMTCGXK[292736]
    • 803: L12398
      Homo sapiens dopamine receptor D4 (DRD4) mRNA, complete cds
      gi|291945|gb|L12398.1|HUMD4C[291945]
    • 804: M86383
      Homo sapiens nicotinic acetylcholine receptor alpha 3 subunit precursor, mRNA,
      complete cds
      gi|177897|gb|M86383.1|HUMA3NARSP[177897]
    • 805: NG000019
      Homo sapiens chorionic gonadotropin beta region (CGB@) on chromosome 19
      gi|18860921|ref|NG000019.2|[18860921]
    • 807: NM012245
      Homo sapiens SKI-interacting protein (SNW1), mRNA
      gi|18860912|ref|NM012245.2|[18860912]
    • 808: NM006750
      Homo sapiens syntrophin, beta 2 (dystrophin-associated protein A1, 59 kD, basic
      component 2) (SNTB2), transcript variant 1, mRNA
      gi|18860911|ref|NM006750.2|[18860911]
    • 809: NM130845
      Homo sapiens syntrophin, beta 2 (dystrophin-associated protein A1, 59 kD, basic
      component 2) (SNTB2), transcript variant 2, mRNA
      gi|18860909|ref|NM130845.1|[18860909]
    • 810: NM002846
      Homo sapiens protein tyrosine phosphatase, receptor type, N (PTPRN), mRNA
      gi|18860905|ref|NM002846.2|[18860905]
    • 811: NM002845
      Homo sapiens protein tyrosine phosphatase, receptor type, M (PTPRM), mRNA
      gi|18860903|ref|NM002845.2|[18860903]
    • 812: NM002844
      Homo sapiens protein tyrosine phosphatase, receptor type, K (PTPRK), mRNA
      gi|18860901|ref|NM002844.2|[18860901]
    • 813: NM002843
      Homo sapiens protein tyrosine phosphatase, receptor type, J (PTPRJ), mRNA
      gi|18860899|ref|NM002843.2|[18860899]
    • 814: NM002841
      Homo sapiens protein tyrosine phosphatase, receptor type, G (PTPRG), mRNA
      gi|18860897|ref|NM002841.2|[18860897]
    • 815: NM130440
      Homo sapiens protein tyrosine phosphatase, receptor type, F (PTPRF), transcript
      variant 2, mRNA
      gi|18860895|ref|NM130440.1|[18860895]
    • 816: NM130393
      Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript
      variant 4, mRNA
      gi|18860893|ref|NM130393.1|[18860893]
    • 817: NM130392
      Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript
      variant 3, mRNA
      gi|18860891|ref|NM130392.1|[18860891]
    • 818: NM130391
      Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript
      variant 2, mRNA
      gi|18860889|ref|NM130391.1|[18860889]
    • 819: NM003682
      Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 4, mRNA
      gi|18860876|ref|NM003682.2|[18860876]
    • 820: NM130476
      Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 8, mRNA
      gi|18860874|ref|NM130476.1|[18860874]
    • 821: NM130475
      Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 7, mRNA
      gi|18860872|ref|NM130475.1|[18860872]
    • 822: NM002840
      Homo sapiens protein tyrosine phosphatase, receptor type, F (PTPRF), transcript
      variant 1, mRNA
      gi|18860871|ref|NM002840.2|[18860871]
    • 823: NM130474
      Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 6, mRNA
      gi|18860869|ref|NM130474.2|[18860869]
    • 824: NM130473
      Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 5, mRNA
      gi|18860867|ref|NM130473.1|[18860867]
    • 825: NM130472
      Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 3, mRNA
      gi|18860865|ref|NM130472.1|[18860865]
    • 826: NM130471
      Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 2, mRNA
      gi|18860863|ref|NM130471.1|[18860863]
    • 827: NM130470
      Homo sapiens MAP-kinase activating death domain (MADD), transcript variant 1, mRNA
      gi|18860861|ref|NM130470.1|[18860861]
    • 828: NM006504
      Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript
      variant 1, mRNA
      gi|18860860|ref|NM006504.2|[18860860]
    • 829: NM130435
      Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript
      variant 2, mRNA
      gi|18860858|ref|NM130435.1|[18860858]
    • 830: AJ431177
      Homo sapiens mRNA for WIRE protein
      gi|18857713|emb|AJ431177.1|HSA431177[18857713]
    • 831: NM006474
      Homo sapiens lung type-I cell membrane-associated glycoprotein (T1A-2), mRNA
      gi|18767663|ref|NM006474.2|[18767663]
    • 833: NM006794
      Homo sapiens G protein-coupled receptor 75 (GPR75), mRNA
      gi|5803024|ref|NM006794.1|[5803024]
    • 834: NM002842
      Homo sapiens protein tyrosine phosphatase, receptor type, H (PTPRH), mRNA
      gi|4506312|ref|NM002842.1|[4506312]
    • 835: NM002839
      Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript
      variant 1, mRNA
      gi|4506308|ref|NM002839.1|[4506308]
    • 836: BC024145
      Homo sapiens, TNF receptor-associated factor 1, clone MGC:10353 IMAGE:3832475, mRNA, complete cds
      gi|18848176|gb|BC024145.1|[18848176]
    • 837: AF469756
      Homo sapiens clone S9 interleukin-1 receptor type I (IL1R1) gene, partial sequence
      gi|18846656|gb|AF469756.1|[18846656]
    • 838: AF469755
      Homo sapiens clone S8 interleukin-1 receptor type I (IL1R1) gene, partial sequence
      gi|18846655|gb|AF469755.1|[18846655]
    • 839: AF469754
      Homo sapiens clone S7 interleukin-1 receptor type I (IL1R1) gene, partial sequence
      gi|18845036|gb|AF469754.1|[18845036]
    • 841: BM565570
      ih27b03.x1 Human insulinoma Homo sapiens cDNA clone IMAGE: 3′ similar to SW:FCEG_HUMAN P30273 HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR GAMMA-SUBUNIT
      PRECURSOR; mRNA sequence
      gi|18825852|gb|BM565570.1|BM565570[18825852]
    • 842: AF416711
      Homo sapiens Fc-gamma receptor IIc5 mRNA, partial cds
      gi|18765992|gb|AF416711.1|[18765992]
    • 843: NM023068
      Homo sapiens sialoadhesin (SN), mRNA
      gi|18765743|ref|NM023068.2|[18765743]
    • 844: NM004782
      Homo sapiens synaptosomal-associated protein, 29 kD (SNAP29), mRNA
      gi|18765736|ref|NM004782.2|[18765736]
    • 845: NM130798
      Homo sapiens synaptosomal-associated protein, 23 kD (SNAP23), transcript variant
      2, mRNA
      gi|18765730|ref|NM130798.1|[18765730]
    • 846: NM003825
      Homo sapiens synaptosomal-associated protein, 23 kD (SNAP23), transcript variant
      1, mRNA
      gi|18765728|ref|NM003825.2|[18765728]
    • 850: AF439409
      Homo sapiens G-protein-coupled receptor kinase 7 (GRK7) mRNA, GRK7-S allele,
      complete cds
      gi|17933258|gb|AF439409.1|[17933258]
    • 851: NM032211
      Homo sapiens lysyl oxidase-like 4 (LOXL4), mRNA
      gi|16933522|ref|NM032211.4|[16933522]
    • 852: AF411122
      Homo sapiens importin 4 mRNA, complete cds
      gi|18700634|gb|AF411122.1|[18700634]
    • 894: NM130441
      Homo sapiens C-type (calcium dependent, carbohydrate-recognition domain) lectin,
      superfamily member 11 (CLECSF11), mRNA
      gi|18466805|ref|NM130441.1|[18466805]
    • 895: NM030876
      Homo sapiens olfactory receptor, family 5, subfamily V, member 1 (OR5V1), mRNA
      gi|14495550|ref|NM030876.2|[14495550]
    • 896: NM032732
      Homo sapiens hypothetical protein MGC10763 (IL17RL), mRNA
      gi|14249349|ref|NM032732.1|[14249349]
    • 897: NM030959
      Homo sapiens olfactory receptor, family 12, subfamily D, member 3 (OR12D3), mRNA
      gi|13624334|ref|NM030959.1|[13624334]
    • 898: NM018842
      Homo sapiens insulin receptor tyrosine kinase substrate (LOC55971), mRNA
      gi|10047119|ref|NM018842.1|[10047119]
    • 899: NM018844
      Homo sapiens B-cell receptor-associated protein BAP29 (BAP29), mRNA
      gi|9994198|ref|NM018844.1|[9994198]
    • 900: NM002825
      Homo sapiens pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) (PTN), mRNA
      gi|18656935|ref|NM002825.2|[18656935]
    • 904: NM016372
      Homo sapiens seven transmembrane domain orphan receptor (TPRA40), mRNA
      gi|7705964|ref|NM016372.1|[7705964]
    • 905: NM014288
      Homo sapiens integrin beta 3 binding protein (beta3-endonexin) (ITGB3BP), mRNA
      gi|7657205|ref|NM014288.1|[7657205]
    • 906: L43588
      Homo sapiens T cell antigen receptor mRNA, partial cds
      gi|18654191|gb|L43588.1|HUMTCARF[18654191]
    • 907: AB050954
      Homo sapiens irs-2 gene for insulin receptor substrate-2, partial cds
      gi|18652856|dbj|AB050954.1|[18652856]
    • 923: U77589
      Homo sapiens MHC class II HLA-DQ-alpha chain (HLA-DQA1) mRNA, HLA-DQA1*0104 allele, complete cds
      gi|1916744|gb|U77589.1|HSU77589[1916744]
    • 924: AF410465
      Homo sapiens importin 9 mRNA, complete cds
      gi|15529702|gb|AF410465.1|[15529702]
    • 925: AF332759
      Homo sapiens partially duplicated CHRNA7 gene, hybrid intron A/4 and partial exon 5
      gi|13345792|gb|AF332759.1|[13345792]
    • 926: AF332758
      Homo sapiens alpha-7 nicotinic cholinergic receptor subunit (CHRNA7) gene, partial intron 4 and partial cds
      gi|13345790|gb|AF332750.1|[13345790]
    • 927: NM003744
      Homo sapiens numb homolog (Drosophila) (NUMB), mRNA
      gi|18644887|ref|NM003744.2|[18644887]
    • 928: NM003681
      Homo sapiens pyridoxal (pyridoxine, vitamin B6) kinase (PDXK), mRNA
      gi|18644884|ref|NM003681.2|[18644884]
    • 929: NM080706
      Homo sapiens transient receptor potential cation channel, subfamily V, member 1
      (TRPV1), transcript variant 3, mRNA
      gi|18375670|ref|NM080706.1|[18375670]
    • 930: NM080705
      Homo sapiens transient receptor potential cation channel, subfamily V, member 1
      (TRPV1), transcript variant 4, mRNA
      gi|18375668|ref|NM080705.1|[18375668]
    • 931: NM080704
      Homo sapiens transient receptor potential cation channel, subfamily V, member 1
      (TRPV1), transcript variant 1, mRNA
      gi|18375666|ref|NM080704.1|[18375666]
    • 932: NM018727
      Homo sapiens transient receptor potential cation channel, subfamily V, member 1
      (TRPV1), transcript variant 2, mRNA
      gi|18375664|ref|NM018727.3|[18375664]
    • 933: NM080819
      Homo sapiens G protein-coupled receptor 78 (GPR78), mRNA
      gi|18201873|ref|NM080819.1|[18201873]
    • 934: NM080738
      Homo sapiens EDAR-associated death domain (EDARADD), mRNA
      gi|18152768|ref|NM080738.1|[18152768]
    • 935: NM080491 Homo sapiens GRB2-associated binding protein 2 (GAB2), transcript variant 1, mRNA gi|18105041|ref|NM080491.1|[18105041]
    • 936: NM012296 Homo sapiens GRB2-associated binding protein 2 (GAB2), transcript variant 2, mRNA gi|18105040|ref|NM012296.2|[18105040]
    • 937: NM032027 Homo sapiens beta-amyloid binding protein precursor (BBP), mRNA gi|17738309|ref|NM032027.2|[17738309]
    • 938: NM057159 Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 2, mRNA
      gi|16950637|ref|NM057159.1|[16950637]
    • 939: NM001401 Homo sapiens endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 (EDG2), transcript variant 1, mRNA
      gi|16950635|ref|NM001401.2|[16950635]
    • 940: NM007070 Homo sapiens FKBP-associated protein (FAP48), transcript variant 2, mRNA gi|16933538|ref|NM007070.2|[16933538]
    • 941: NM053274 Homo sapiens FKBP-associated protein (FAP48), transcript variant 1, mRNA gi|16933536|ref|NM053274.1|[16933536]
    • 942: NM003726 Homo sapiens src family associated phosphoprotein 1 (SCAP1), mRNA gi|16753209|ref|NM003726.2|[16753209]
    • 943: NM033632 Homo sapiens F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) (FBXW7), transcript variant 1, mRNA
      gi|16117780|ref|NM033632.1|[16117780]
    • 944: NM018315 Homo sapiens F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) (FBXW7), transcript variant 2, mRNA
      gi|16117778|ref|NM018315.2|[16117778]
    • 945: NM021203 Homo sapiens APMCF1 protein (APMCF1), mRNA
      gi|14917112|ref|NM021203.2|[14917112]
    • 946: NM002927 Homo sapiens regulator of G-protein signalling 13 (RGS13), mRNA gi|14589857|ref|NM002927.2|[14589857]
    • 949: NM020167 Homo sapiens neuromedin U receptor 2 (NMU2R), mRNA
      gi|9910461|ref|NM020167.1|[9910461]
    • 950: NM020149 Homo sapiens Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) (MEIS2), mRNA
      gi|9910355|ref|NM020149.1|[9910355]
    • 951: AF190052 Homo sapiens interleukin 1 receptor type I (IL1R1) gene, exon 1C sequence gi|9719300|gb|AF190052.1|[9719300]
    • 952: NM018965 Homo sapiens triggering receptor expressed on myeloid cells 2 (TREM2), mRNA gi|9507202|ref|NM018965.1|[9507202]
    • 953: NM018643 Homo sapiens triggering receptor expressed on myeloid cells 1 (TREM1), mRNA gi|8924261|ref|NM018643.1|[8924261]
    • 954: NM018647 Homo sapiens tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), mRNA gi|8924251|ref|NM018647.1|[8924251]
    • 955: NM018695 Homo sapiens erbb2 interacting protein (ERBB2IP), mRNA
      gi|8923908|ref|NM018695.1|[8923908]
    • 956: NM017636 Homo sapiens transient receptor potential cation channel, subfamily M, member 4(TRPM4), mRNA gi|8923048|ref|NM017636.1|[8923048]
    • 958: NM016559 Homo sapiens PXR2b protein (PXR2b), mRNA
      gi|7706670|ref|NM016559.1|[7706670]
    • 959: NM016382 Homo sapiens natural killer cell receptor 2B4 (CD244), mRNA
      gi|7706528|ref|NM016382.1|[7706528]
    • 962: NM015986 Homo sapiens cytokine receptor-like factor 3 (CRLF3), mRNA
      gi|7705331|ref|NM015986.1|[7705331]
    • 963: NM014815 Homo sapiens KIAA0130 gene product (KIAA0130), mRNA
      gi|7661929|ref|NM014815.1|[7661929]
    • 964: NM014053 Homo sapiens FLVCR protein (FLVCR), mRNA
      gi|7661707|ref|NM014053.1|[7661707]
    • 965: NM014478 Homo sapiens calcitonin gene-related peptide-receptor component protein (CGRP-RCP), mRNA gi|7656976|ref|NM014478.1|[7656976]
    • 966: NM012470
      Homo sapiens transportin-SR (TRN-SR), mRNA
      gi|6912733|ref|NM012470.1|[6912733]
    • 967: NM007357 Homo sapiens low density lipoprotein receptor defect C complementing (LDLC), mRNA gi|6678675|ref|NM007357.1|[6678675]
    • 969: NM007324 Homo sapiens MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor (MADHIP), transcript variant 1, mRNA gi|6552338|ref|NM007324.1|[6552338]
    • 970: NM007323 Homo sapiens MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor (MADHIP), transcript variant 2, mRNA gi|6552336|ref|NM007323.1|[6552336]
    • 971: NM005162 Homo sapiens angiotensin receptor-like 2 (AGTRL2), mRNA
      gi|6031157|ref|NM005162.21[6031157]
    • 972: NM005501 Homo sapiens integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b, mRNA
      gi|6006010|ref|NM005501.1|[6006010]
    • 975: NM007053 Homo sapiens natural killer cell receptor, immunoglobulin superfamily member (BY55), mRNA gi|5901909|ref|NM007053.1|[5901909]
    • 978: NM006254 Homo sapiens protein kinase C, delta (PRKCD), mRNA
      gi|5453969|ref|NM006254.1|[5453969]
    • 979: NM005761 Homo sapiens plexin C1 (PLXNC1), mRNA
      gi|5032222|ref|NM005761.1|[5032222]
    • 980: NM005866 Homo sapiens sigma receptor (SR31747 binding protein 1) (SR-BP1), mRNA gi|5032116|ref|NM005866.1|[5032116]
    • 982: NM005506 Homo sapiens CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II) (CD36L2), mRNA gi|5031630|ref|NM005506.1|[5031630]
    • 984: NM004799 Homo sapiens MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor (MADHIP), transcript variant 3, mRNA gi|4759059|ref|NM004799.1|[4759059]
    • 985: NM004292 Homo sapiens ras inhibitor (RIN1), mRNA
      gi|4759039|ref|NM004292.1|[4759039]
    • 986: NM004828 Homo sapiens lymphocyte antigen 95 (activating NK-receptor; NK-p44) (LY95), mRNA gi|4758693|ref|NM004828.1|[4758693]
    • 987: NM004767 Homo sapiens endothelin type b receptor-like protein 2 (ET(B)R-LP-2), mRNA gi|4758309|ref|NM004767.1|[4758309]
    • 988: NM004440 Homo sapiens EphA7 (EPHA7), mRNA
      gi|4758281|ref|NM004440.1|[4758281]
    • 989: NM003999 Homo sapiens oncostatin M receptor (OSMR), mRNA
      gi|4557039|ref|NM003999.1|[4557039]
    • 990: NM003904 Homo sapiens zinc finger protein 259 (ZNF259), mRNA
      gi|4508020|ref|NM003904.1|[4508020]
    • 991: NM003305 Homo sapiens transient receptor potential cation channel, subfamily C, member 3(TRPC3), mRNA gi|4507686|ref|NM003305.1|[4507686]
    • 992: NM003804 Homo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mRNA gi|4506538|ref|NM003804.1|[4506538]
    • 993: NM003626 Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 (PPFIA1), mRNA
      gi|4505982|ref|NM003626.1|[4505982]
    • 994: NM003876 Homo sapiens putative receptor protein (PMI), mRNA
      gi|4505900|ref|NM003876.1|[4505900]
    • 995: NM003559 Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type II, beta (PIP5K2B), mRNA gi|4505818|ref|NM003559.1|[4505818]
    • 996: NM003629 Homo sapiens phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) (PIK3R3), mRNA gi|4505804|ref|NM003629.1|[4505804]
    • 997: NM003676 Homo sapiens degenerative spermatocyte homolog, lipid desaturase (Drosophila) (DEGS), mRNA gi|4505192|ref|NM003676.1|[4505192]
    • 998: NM002270 Homo sapiens karyopherin (importin) beta 2 (KPNB2), mRNA
      gi|4504906|ref|NM002270.1|[4504906]
    • 999: NM002204 Homo sapiens integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant a, mRNA
      gi|4504746|ref|NM002204.1|[4504746]
    • 1000: NM001560 Homo sapiens interleukin 13 receptor, alpha 1 (IL13RA1), mRNA
      gi|4504646|ref|NM001560.1|[4504646]
      sapiens AND receptor NOT similar NOT non-receptor NOT nuclear NOT receptor-associated NOT “thyroid hormone” NOT “steroid receptor”
    • 779: NM000842
      Homo sapiens glutamate receptor, metabotropic 5 (GRM5), mRNA
      gi|4504142|ref|NM000842.1|[4504142]
    • 780: NM001883
      Homo sapiens corticotropin releasing hormone receptor 2 (CRHR2), mRNA
      gi|4503044|ref|NM001883.1|[4503044]
    • 781: NM001873
      Homo sapiens carboxypeptidase E (CPE), mRNA
      gi|4503008|ref|NM001873.1|[4503008]
    • 783: L29395
      Homo sapiens v-erbB-related protein gene, partial cds
      gi|459807|gb|L29395.1|HUMERBB[459807]
    • 784: L08584
      Homo sapiens T cell receptor beta chain (TCRB) mRNA, partial cds
      gi|307497|gb|L08584.1|HUMTCVB7A[307497]
    • 786: NM015638
      Homo sapiens chromosome 20 open reading frame 188 (C20orf188), mRNA
      gi|18158415|ref|NM015638.1|[18158415]
    • 787: NM058167
      Homo sapiens ubiquitin conjugating enzyme 6 (Ubc6p), mRNA
      gi|17157996|ref|NM058167.1|[17157996]
    • 788: NM054032
      Homo sapiens G protein-coupled receptor MRGX4 (MRGX4), mRNA
      gi|16876454|ref|NM054032.1|[16876454]
    • 789: NM054031
      Homo sapiens G protein-coupled receptor MRGX3 (MRGX3), mRNA
      gi|16876452|ref|NM054031.1|[16876452]
    • 790: NM054030
      Homo sapiens G protein-coupled receptor MRGX2 (MRGX2), mRNA
      gi|16876450|ref|NM054030.1|[16876450]
    • 791: NM052931
      Homo sapiens activating NK receptor (KALI), mRNA
      gi|16418406|ref|NM052931.1|[16418406]
    • 792: NM032871
      Homo sapiens tumor necrosis factor receptor superfamily, member 19-like (TNFRSF19L), mRNA
      gi|14249611|ref|NM032871.1|[14249611]
    • 793: NM032553
      Homo sapiens putative purinergic receptor (FKSG79), mRNA
      gi|14211848|ref|NM032553.1|[14211848]
    • 794: NM025179
      Homo sapiens plexin A2 (PLXNA2), mRNA
      gi|13378152|ref|NM025179.1|[13378152]
    • 795: NM024419
      Homo sapiens Phosphatidylglycerophosphate Synthase (PGS1), mRNA
      gi|13259369|ref|NM024419.1|[13259369]
    • 796: NM021249
      Homo sapiens sorting nexin 6 (SNX6), mRNA
      gi|13027619|ref|NM021249.1|[13027619]
    • 797: NM014045
      Homo sapiens DKFZP564C1940 protein (DKFZP564C1940), mRNA
      gi|13027587|ref|NM014045.1|[13027587]
    • 798: NM080923
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript
      variant 4, mRNA
      gi|18641365|ref|NM080923.1|[18641365]
    • 799: NM080922
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript
      variant 3, mRNA
      gi|18641363|ref|NM080922.1|[18641363]
    • 800: NM080921
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript
      variant 2, mRNA
      gi|18641361|ref|NM080921.1|[18641361]
    • 801: NM130386
      Homo sapiens collectin sub-family member 12 (COLEC12), transcript variant I, mRNA
      gi|18641359|ref|NM130386.1|[18641359]
    • 802: NM030781
      Homo sapiens collectin sub-family member 12 (COLEC12), transcript variant II, mRNA
      gi|18641357|ref|NM030781.2|[18641357]
    • 803: NM002838
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript
      variant 1, mRNA
      gi|18641346|ref|NM002838.2|[18641346]
    • 804: NM130770
      Homo sapiens 5-hydroxytryptamine receptor 3 subunit C (HTR3C), mRNA
      gi|18640739|ref|NM130770.1|[18640739]
    • 813: BD010218
      Novel hemopoietin receptor protein, NR12
      gi|18638591|dbj|BD010218.1|[18638591]
    • 814: BD010217
      Novel hemopoietin receptor protein, NR12
      gi|18638590|dbj|BD010217.1|[18638590]
    • 815: BD010216
      Novel hemopoietin receptor protein, NR12
      gi|18638589|dbj|BD010216.1|[18638589]
    • 816: BD010215
      Novel hemopoietin receptor protein, NR12
      gi|18638588|dbj|BD010215.1|[18638588]
    • 817: BD010214
      Novel hemopoietin receptor protein, NR12
      gi|18638587|dbj|BD010214.1|[18638587]
    • 818: BD010125
      Peptide leukotrien receptor
      gi|18638498|dbj|BD010125.1|[18638498]
    • 819: BD010114
      Novel receptor and gene encoding the same
      gi|18638487|dbj|BD010114.1|[18638487]
    • 820: BD010057
      Novel G protein coupled receptor protein and its DNA
      gi|18638430|dbj|BD010057.1|[18638430]
    • 821: BD010056
      Novel G protein coupled receptor protein and its DNA
      gi|18638429|dbj|BD010056.1|[18638429]
    • 822: BD010055
      Novel G protein coupled receptor protein and its DNA
      gi|18638428|dbj|BD010055.1|[18638428]
    • 823: BD010054
      Novel G protein coupled receptor protein and its DNA
      gi|18638427|dbj|BD010054.1|[18638427]
    • 824: BD010053
      Novel G protein coupled receptor protein and its DNA
      gi|18638426|dbj|BD010053.1|[18638426]
    • 825: BD010052
      Novel G protein coupled receptor protein and its DNA
      gi|18638425|dbj|BD010052.1|[18638425]
    • 826: BD010051
      Novel G protein coupled receptor protein and its DNA
      gi|18638424|dbj|BD010051.1|[18638424]
    • 827: BD010050
      Novel G protein coupled receptor protein and its DNA
      gi|18638423|dbj|BD010050.1|[18638423]
    • 828: BD010049
      Novel G protein coupled receptor protein and its DNA
      gi|18638422|dbj|BD010049.1|[18638422]
    • 829: BD010046
      Novel G protein coupled receptor protein and its DNA
      gi|18638419|dbj|BD010046.1|[18638419]
    • 830: BD010035
      Novel G protein coupled receptor protein and its DNA
      gi|18638408|dbj|BD010035.1|[18638408]
    • 831: BD010034
      Novel G protein coupled receptor protein and its DNA
      gi|18638407|dbj|BD010034.1|[18638407]
    • 832: BD010028
      Novel G protein coupled receptor protein and its DNA
      gi|18638401|dbj|BD010028.1|[18638401]
    • 833: BD010022
      Novel G protein coupled receptor protein and its DNA
      gi|18638395|dbj|BD010022.1|[18638395]
    • 834: BD009263
      GABAA receptor subunit epsilon-related protein
      gi|18637636|dbj|BD009263.1|[18637636]
    • 835: BD009262
      GABAA receptor subunit epsilon-related protein
      gi|18637635|dbj|BD009262.1|[18637635]
    • 836: BD009261
      GABAA receptor subunit epsilon-related protein
      gi|18637634|dbj|BD009261.1|[18637634]
    • 837: BD009260
      GABAA receptor subunit epsilon-related protein
      gi|18637633|dbj|BD009260.1|[18637633]
    • 838: BD006753
      Human G protein chemokine receptor HDGNR10
      gi|18635124|dbj|BD006753.1|[18635124]
    • 843: E51301
      Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein
      gi|18633577|dbj|E51301.1|[18633577]
    • 844: E51300
      Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein
      gi|18633576|dbj|E51300.1|[18633576]
    • 845: E51299
      Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein
      gi|18633575|dbj|E51299.1|[18633575]
    • 846: E51298
      Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein
      gi|18633574|dbj|E51298.1|[18633574]
    • 847: E51297
      Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein
      gi|18633573|dbj|E51297.1|[18633573]
    • 848: E51296
      Novel G protein-coupled receptor protein and gene of said G protein-coupled receptor protein
      gi|18633572|dbj|E51296.1|[18633572]
    • 849: E50838
      Novel G protein-coupled receptor
      gi|18633543|dbj|E50838.1|[18633543]
    • 850: E50837
      Novel G protein-coupled receptor
      gi|18633542|dbj|E50837.1|[18633542]
    • 851: E50836
      Novel G protein-coupled receptor
      gi|18633541|dbj|E50836.1|[18633541]
    • 852: E50835
      Novel G protein-coupled receptor
      gi|18633540|dbj|E50835.1|[18633540]
    • 853: E50834
      Novel G protein-coupled receptor
      gi|18633539|dbj|E50834.1|[18633539]
    • 854: E50833
      Novel G protein-coupled receptor
      gi|18633538|dbj|E50833.1|[18633538]
    • 873: BD003056
      Novel G protein-coupled receptor protein and DNA thereof
      gi|18631017|dbj|BD003056.1|[18631017]
    • 874: E55122
      Novel G protein-coupled receptor and the G protein-coupled receptor gene
      gi|18629753|dbj|E55122.1|[18629753]
    • 875: E55121
      Novel G protein-coupled receptor and the G protein-coupled receptor gene
      gi|18629752|dbj|E55121.1|[18629752]
    • 876: E55120
      Novel G protein-coupled receptor and the G protein-coupled receptor gene
      gi|18629751|dbj|E55120.1|[18629751]
    • 877: E55119
      Novel G protein-coupled receptor and the G protein-coupled receptor gene
      gi|18629750|dbj|E55119.1|[18629750]
    • 878: E55118
      Novel G protein-coupled receptor and the G protein-coupled receptor gene
      gi|18629749|dbj|E55118.1|[18629749]
    • 879: E55117
      Novel G protein-coupled receptor and the G protein-coupled receptor gene
      gi|18629748|dbj|E55117.1|[18629748]
    • 880: E49128
      Novel G protein-conjugated receptor protein
      gi|18629265|dbj|E49128.1|[18629265]
    • 881: E49127
      Novel G protein-conjugated receptor protein
      gi|18629264|dbj|E49127.1|[18629264]
    • 882: E49126
      Novel G protein-conjugated receptor protein
      gi|18629263|dbj|E49126.1|[18629263]
    • 883: E49125
      Novel G protein-conjugated receptor protein
      gi|18629262|dbj|E49125.1|[18629262]
    • 884: E49124
      Novel G protein-conjugated receptor protein
      gi|18629261|dbj|E49124.1|[18629261]
    • 885: E49123
      Novel G protein-conjugated receptor protein
      gi|18629260|dbj|E49123.1|[18629260]
    • 887: E58499
      Novel G protein-coupled receptor protein, DNA and utilization thereof
      gi|18628416|dbj|E58499.1|[18628416]
    • 888: E58495
      Novel G protein-coupled receptor protein, DNA and utilization thereof
      gi|18628412|dbj|E58495.1|[18628412]
    • 889: E58494
      Novel G protein-coupled receptor protein, DNA and utilization thereof
      gi|18628411|dbj|E58494.1|[18628411]
    • 890: E58488
      Novel G protein-coupled receptor protein, DNA and utilization thereof
      gi|18628405|dbj|E58488.1|[18628405]
    • 891: E58485
      Novel G protein-coupled receptor protein, DNA and utilization thereof
      gi|18628402|dbj|E58485.1|[18628402]
    • 892: E58484
      Novel G protein-coupled receptor protein, DNA and utilization thereof
      gi|18628401|dbj|E58484.1|[18628401]
    • 893: E58479
      Novel G protein-coupled receptor protein, DNA and utilization thereof
      gi|18628396|dbj|E58479.1|[18628396]
    • 902: E43451
      Novel protein G-coupled receptor protein and DNA thereof
      gi|18627717|dbj|E43451.1|[18627717]
    • 903: E43450
      Novel protein G-coupled receptor protein and DNA thereof
      gi|18627716|dbj|E43450.1|[18627716]
    • 904: E41270
      Novel G protein-conjugate receptor protein and its DNA
      gi|18627502|dbj|E41270.1|[18627502]
    • 905: E41269
      Novel G protein-conjugate receptor protein and its DNA
      gi|18627501|dbj|E41269.1|[18627501]
    • 906: E41268
      Novel G protein-conjugate receptor protein and its DNA
      gi|18627500|dbj|E41268.1|[18627500]
    • 907: E40003
      Novel G protein-conjugate receptor protein and its DNA
      gi|18627119|dbj|E40003.1|[18627119]
    • 908: E40000
      Novel G protein-conjugate receptor protein and its DNA
      gi|18627116|dbj|E40000.1|[18627116]
    • 909: E39999
      Novel G protein-conjugate receptor protein and its DNA
      gi|18627115|dbj|E39999.1|[18627115]
    • 910: E39824
      Novel guanosine triphospate (GTP)-binding protein-conjugate receptor protein
      gi|18627105|dbj|E39824.1|[18627105]
    • 911: E39817
      Novel guanosine triphospate (GTP)-binding protein-conjugate receptor protein
      gi|18627098|dbj|E39817.1|[18627098]
    • 912: E39816
      Novel guanosine triphospate (GTP)-binding protein-conjugate receptor protein
      gi|18627097|dbj|E39816.1|[18627097]
    • 913: E39815
      Novel guanosine triphospate (GTP)-binding protein-conjugate receptor protein
      gi|18627096|dbj|E39815.1|[18627096]
    • 929: E34464
      Novel Toll-like receptor and gene thereof
      gi|18624350|dbj|E34464.1|[18624350]
    • 930: E33807
      Human splice mutant CXCR4B of CXCR4 chemokine receptor
      gi|18624164|dbj|E33807.1|[18624164]
    • 931: E33806
      Human splice mutant CXCR4B of CXCR4 chemokine receptor
      gi|18624163|dbj|E33806.1)[18624163]
    • 941: E63757
      Human nurse cell receptor gene
      gi|18622844|dbj|E63757.1|[18622844]
    • 942: E63756
      Human nurse cell receptor gene
      gi|18622843|dbj|E63756.1|[18622843]
    • 943: E63754
      Human nurse cell receptor gene
      gi|18622841|dbj|E63754.1|[18622841]
    • 944: E49275
      Novel G protein-conjugated receptor protein and DNA thereof
      gi|18622037|dbj|E49275.1|[18622037]
    • 945: E44151
      Novel G protein-coupled receptor protein and DNA thereof
      gi|18622012|dbj|E44151.1|[18622012]
    • 946: E44032
      Novel G protein-coupled receptor protein and DNA and ligand of the same
      gi|18621998|dbj|E44032.1|[18621998]
    • 947: AX350990
      Sequence 24 from Patent WO0190358
      gi|18616366|emb|AX350990.1|[18616366]
    • 948: AX350988
      Sequence 22 from Patent WO0190358
      gi|18616364|emb|AX350988.1|[18616364]
    • 949: AX350984
      Sequence 18 from Patent WO0190358
      gi|18616360|emb|AX350984.1|[18616360]
    • 950: AX350982
      Sequence 16 from Patent WO0190358
      gi|18616358|emb|AX350982.1|[18616358]
    • 951: AX350981
      Sequence 15 from Patent WO0190358
      gi|18616357|emb|AX350981.1|[18616357]
    • 952: AX350979
      Sequence 13 from Patent WO0190358
      gi|18616355|emb|AX350979.1|[18616355]
    • 953: AX350975
      Sequence 9 from Patent WO0190358-
      gi|18616351|emb|AX350975.1|[18616351]
    • 954: AX350973
      Sequence 7 from Patent WO0190358
      gi|18616349|emb|AX350973.1|[18616349]
    • 955: AX350969
      Sequence 3 from Patent WO0190358
      gi|18616345|emb|AX350969.1|[18616345]
    • 956: AX350967
      Sequence 1 from Patent WO0190358
      gi|18616343|emb|AX350967.1|[18616343]
    • 957: NM005608
      Homo sapiens protein tyrosine phosphatase, receptor type, C-associated protein
      (PTPRCAP), mRNA
      gi|5032004|ref|NM005608.1|[5032004]
    • 958: XM012097
      Homo sapiens olfactory receptor, family 6, subfamily A, member 1 (OR6A1), mRNA
      gi|18605332|ref|XM012097.3|[18605332]
    • 959: XM090173
      Homo sapiens olfactory receptor, family 5, subfamily L, member 2 (OR5L2), mRNA
      gi|1860518|ref|XM090173.1|[18605181]
    • 960: XM055369
      Homo sapiens pro-oncosis receptor inducing membrane injury gene (PORIMIN), mRNA
      gi|18604484|ref|XM055369.2|[18604484]
    • 961: XM041961
      Homo sapiens PYK2 N-terminal domain-interacting receptor 1 (NIR1), mRNA
      gi|18604126|ref|XM041961.2|[18604126]
    • 962: XM040037
      Homo sapiens adrenergic, beta, receptor kinase 1 (ADRBK1), mRNA
      gi|18604053|ref|XM040037.3|[18604053]
    • 963: XM045532
      Homo sapiens olfactory receptor, family 51, subfamily E, member 2 (OR51E2), mRNA
      gi|18603788|ref|XM045532.2|[18603788]
    • 964: XM091465
      Homo sapiens olfactory receptor, family 4, subfamily D, member 1 (OR4D1), mRNA
      gi|18603196|ref|XM091465.1|[18603196]
    • 965: XM036784
      Homo sapiens phosphatidylserine receptor (KIAA0585), mRNA
      gi|18603024|ref|XM036784.3|[18603024]
    • 966: XM036728
      Homo sapiens ryanodine receptor 3 (RYR3), mRNA
      gi|18602746|ref|XM036728.3|[18602746]
    • 967: XM084025
      Homo sapiens complement component 5 receptor 1 (C5a ligand) (C5R1), mRNA
      gi|18601827|ref|XM084025.1|[18601827]
    • 968: XM009107
      Homo sapiens KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 (KDELR1), mRNA
      gi|18601740|ref|XM009107.6|[18601740]
    • 969: XM027883
      Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),
      interacting protein (liprin), alpha 3 (PPFIA3), mRNA
      gi|18601690|ref|XM027883.2|[18601690]
    • 970: XM027904
      Homo sapiens Fc fragment of IgG, receptor, transporter, alpha (FCGRT), mRNA
      gi|18601656|ref|XM027904.4|[18601656]
    • 971: XM049229
      Homo sapiens dopamine receptor interacting protein (DRIP78), mRNA
      gi|18601498|ref|XM049229.3|[18601498]
    • 972: XM040709
      Homo sapiens prostaglandin F2 receptor negative regulator (PTGFRN), mRNA
      gi|186011300ref|XM040709.2|[18601130]
    • 973: XM003091
      Homo sapiens G protein-coupled receptor 105 (GPR105), mRNA
      gi|18600688|ref|XM003091.5|[18600688]
    • 975: XM010533
      Homo sapiens interleukin 12 receptor, beta 2 (IL12RB2), mRNA
      gi|18600602|ref |XM010533.4|[18600602]
    • 976: NT006318
      Homo sapiens chromosome 4 working draft sequence segment
      gi|18600353|ref|NT006318.7|Hs46475[18600353]
    • 977: XM039145
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 3 (CHRNA3), mRNA
      gi|18597785|ref|XM039145.3|[18597785]
    • 978: XM039151
      Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 4 (CHRNB4), mRNA
      gi|18597777|ref|XM039151.2|[18597777]
    • 979: XM007392
      Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA
      gi|8597722|ref|XM007392.4|[18597722]
    • 980: XM007315
      Homo sapiens receptor-interacting serine-threonine kinase 3 (RIPK3), mRNA
      gi|18597625|ref|XM007315.2|[18597625]
    • 981: NT024675
      Homo sapiens chromosome 15 working draft sequence segment
      gi|18597616|ref|NT024675.7|Hs1524831[18597616]
    • 982: XM051711
      Homo sapiens prostaglandin D2 receptor (DP) (PTGDR), mRNA
      gi|18597012|ref|XM051711.2|[18597012]
    • 983: XM007337
      Homo sapiens kinectin 1 (kinesin receptor) (KTN1), mRNA
      gi|18596970|ref|XM007337.7|[18596970]
    • 984: XM096782
      Homo sapiens putative leukocyte platelet-activating factor receptor (HUMNPIIY20), mRNA
      gi|18596920|ref|XM096782.1|[18596920]
    • 985: XM055898
      Homo sapiens nerve growth factor receptor (TNFRSF16) associated protein 1 (NGFRAP1), mRNA
      gi|18596422|ref|XM055898.3|[18596422]
    • 986: XM018505
      Homo sapiens G protein-coupled receptor 23 (GPR23), mRNA
      gi|18594906|ref|XM018505.3|[18594906]
    • 987: XM096288
      Homo sapiens G protein-coupled receptor 64 (GPR64), mRNA
      gi|18594854|ref|XM096288.1|[18594854]
    • 988: XM096154
      Homo sapiens angiotensin receptor-like 2 (AGTRL2), mRNA
      gi|18593950|ref|XM096154.1|[18593950]
    • 989: XM015620
      Homo sapiens nogo receptor (NOGOR), mRNA
      gi|18593698|ref|XM015620.5|[18593698]
    • 990: XM048563
      Homo sapiens interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2), mRNA
      gi|18593096|ref|XM048563.2|[18593096]
    • 991: XM086754
      Homo sapiens coxsackie virus and adenovirus receptor (CXADR), mRNA
      gi|18592977|ref|XM086754.1|[18592977]
    • 992: XM056242
      Homo sapiens protein C receptor, endothelial (EPCR) (PROCR), mRNA
      gi|18592822|ref|XM056242.3|[18592822]
    • 993: XM097415
      Homo sapiens leukocyte receptor cluster (LRC) member 8 (LENG8), mRNA
      gi|18591238|ref|XM097415.1|[18591238]
    • 994: XM044314
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4 (ILT7), mRNA
      gi|18591234|ref|XM044314.4|[18591234]
    • 995: XM092068
      Homo sapiens olfactory receptor, family 7, subfamily C, member 1 (OR7C1), mRNA
      gi|18591224|ref|XM092068.1|[18591224]
    • 996: XM084042
      Homo sapiens egf-like module containing, mucin-like, hormone receptor-like sequence 2 (EMR2), mRNA
      gi|18591222|ref|XM084042.1|[18591222]
    • 997: XM012893
      Homo sapiens endothelial differentiation, lysophosphatidic acid
      G-protein-coupled receptor, 4 (EDG4), mRNA
      gi|18591032|ref|XM012893.5|[18591032]
    • 998: XM103288
      Homo sapiens polycythemia rubra vera 1; cell surface receptor (PRV1), mRNA
      gi|18590882|ref|XM103288.1|[18590882]
    • 999: XM046103
      Homo sapiens protein tyrosine phosphatase, receptor type, S (PTPRS), mRNA
      gi|18590850|ref|XM046103.3|[18590850]
    • 1000: XM047633
      Homo sapiens thromboxane A2 receptor (TBXA2R), mRNA
      gi|18590817|ref|XM047633.2|[18590817]
    • 1001: XM030637
      Homo sapiens G protein-coupled receptor kinase 7 (GPRK7), mRNA
      gi|18590749|ref|XM030637.3|[18590749]
    • 1002: XM086017
      Homo sapiens plasminogen activator, urokinase receptor (PLAUR), mRNA
      gi|18590707|ref|XM086017.1|[18590707]
    • 1003: XM029455
      Homo sapiens ryanodine receptor 1 (skeletal) (RYR1), mRNA
      gi|18590460|ref|XM029455.2|[18590460]
    • 1004: XM085976
      Homo sapiens leukocyte receptor cluster (LRC) member 3 (LENG3), mRNA
      gi|18590428|ref|XM085976.1|[18590428]
    • 1005: XM084028
      Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (KIR3DL1), mRNA
      gi|18590419|ref|XM084028.1|[18590419]
    • 1006: XM097304
      Homo sapiens leukocyte receptor cluster (LRC) member 1 (LENG1), mRNA
      gi|18590235|ref|XM097304.1|[18590235]
    • 1007: XM050582
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM, domains), member 3 (LILRB3), mRNA
      gi|18590233|ref|XM050582.3|[18590233]
    • 1008: XM041258
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 (LILRB2), mRNA
      gi|18590231|ref|XM041258.3|[18590231]
    • 1009: XM050236
      Homo sapiens leukocyte receptor cluster (LRC) member 4 (LENG4), mRNA
      gi|18590224|ref|XM050236.3|[18590224]
    • 1010: XM048346
      Homo sapiens insulin receptor (INSR), mRNA
      gi|18590185|ref|XM048346.3|[18590185]
    • 1011: XM044591
      Homo sapiens G protein-coupled receptor 108 (GPR108), mRNA
      gi|18590160|ref|XM044591.3|[18590160]
    • 1012: XM085864
      Homo sapiens endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 (EDG8), mRNA
      gi|18589990|ref|XM085864.1|[18589990]
    • 1013: XM044320
      Homo sapiens poliovirus receptor-related 2 (herpesvirus entry mediator B) (PVRL2), mRNA
      gi|18589873|ref|XM044320.4|[18589873]
    • 1014: XM012671
      Homo sapiens olfactory receptor, family 1, subfamily E, member 2 (OR1E2), mRNA
      gi|18588331|ref|XM012671.5|[18588331]
    • 1015: XM085745
      Homo sapiens somatostatin receptor 2 (SSTR2), mRNA
      gi|18588314|ref|XM085745.1|[18588314]
    • 1016: XM008646
      Homo sapiens cytokine receptor-like factor 3 (CRLF3), mRNA
      gi|18588105|ref|XM008646.5|[18588105]
    • 1017: XM008509
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 5 (P2RX5), mRNA
      gi|18587692|ref|XM008509.6|[18587692]
    • 1018: XM030851
      Homo sapiens G protein-coupled receptor kinase-interactor 1 (GIT1), mRNA
      gi|18587652|ref|XM030851.2|[18587652]
    • 1019: XM048233
      Homo sapiens autocrine motility factor receptor (AMFR), mRNA
      gi|18585872|ref|XM048233.3|[18585872]
    • 1020: NT010280
      Homo sapiens chromosome 15 working draft sequence segment
      gi|18584150|ref|NT010280.8|Hs1510437[18584150]
    • 1021: XM039208
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 3 (GABRG3), mRNA
      gi|18584141|ref|XM039208.5|[18584141]
    • 1022: XM030709
      Homo sapiens transient receptor potential cation channel, subfamily M, member 7
      (TRPM7), mRNA
      gi|18583756|ref|XM030709.3|[18583756]
    • 1023: XM085103
      Homo sapiens G protein-coupled receptor (G2A), mRNA
      gi|18583332|ref|XM085103.1|[18583332]
    • 1024: XM040854
      Homo sapiens bradykinin receptor B2 (BDKRB2), mRNA
      gi|18582977|ref|XM040854.2|[18582977]
    • 1025: XM007275
      Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA
      gi|18582976|ref|XM007275.4|[18582976]
    • 1027: XM083897
      Homo sapiens Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) (EBI2), mRNA
      gi|18581588|ref|XM083897.1|[18581588]
    • 1029: XM062656
      Homo sapiens C-type lectin-like receptor (CLEC-6), mRNA
      gi|18580484|ref|XM062656.2|[18580484]
    • 1031: XM084785
      Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),
      interacting protein (liprin), alpha 2 (PPFIA2), mRNA
      gi|18579245|ref|XM084785.1|[18579245]
    • 1032: XM043322
      Homo sapiens peroxisome receptor 1 (PXR1), mRNA
      gi|18579222|ref|XM043322.3|[18579222]
    • 1033: XM090117
      Homo sapiens olfactory receptor, family 8, subfamily G, member 2 (OR8G2), mRNA
      gi|18578560|ref|XM090117.1|[18578560]
    • 1034: XM090109
      Homo sapiens olfactory receptor, family 8, subfamily G, member 1 (OR8G1), mRNA
      gi|18578546|ref|XM090109.1[18578546]
    • 1035: XM035095
      Homo sapiens cortical thymocyte receptor (X. laevis CTX) like (CTXL), mRNA
      gi|18578508|ref|XM035095.4|[18578508]
    • 1036: XM084690
      Homo sapiens olfactory receptor, family 8, subfamily B, member 8 (OR8B8), mRNA
      gi|18578501|ref|XM084690.1|[18578501]
    • 1037: XM012064
      Homo sapiens glutamate receptor, ionotropic, kainate 4 (GRIK4), mRNA
      gi|18578454|ref|XM012064.6|[18578454]
    • 1039: XM031348
      Homo sapiens glutamate receptor, metabotropic 5 (GRM5), mRNA
      gi|18577875|ref|XM031348.2|[18577875]
    • 1040: XM089965
      Homo sapiens olfactory receptor, family 10, subfamily A, member 3 (OR10A3), mRNA
      gi|18577828|ref|XM089965.1|[18577828]
    • 1041: NT030791
      Homo sapiens chromosome 11 working draft sequence segment
      gi|18577645|ref|NT030791.2|Hs1131047[18577645]
    • 1042: XM006549
      Homo sapiens G protein-coupled receptor 48 (GPR48), mRNA
      gi|18577644|ref|XM006549.5|[18577644]
    • 1043: XM054215
      Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 (P2RY2), mRNA
      gi|18577261|ref|XM054215.4|[18577261]
    • 1044: XM038024
      Homo sapiens protein tyrosine phosphatase, receptor type, J (PTPRJ), mRNA
      gi|18577179|ref|XM038024.4|[18577179]
    • 1045: XM049296
      Homo sapiens GDNF family receptor alpha 1 (GFRA1), mRNA
      gi|18576832|ref|XM049296.4|[18576832]
    • 1046: XM005781
      Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), mRNA
      gi|18576581|ref|XM005781.5|[18576581]
    • 1047: XM011904
      Homo sapiens cubilin (intrinsic factor-cobalamin receptor) (CUBN), mRNA
      gi|18576082|ref|XM011904.6|[18576082]
    • 1048: XM005969
      Homo sapiens G protein-coupled receptor kinase 5 (GPRK5), mRNA
      gi|18575440|ref|XM005969.6|[18575440]
    • 1049: XM089569
      Homo sapiens VPS10 domain receptor protein SORCS1 (SORCS1), mRNA
      gi|18574995|ref|XM089569.1|[18574995]
    • 1050: XM005830
      Homo sapiens mannose receptor, C type 1 (MRC1), mRNA
      gi|18574297|ref|XM005830.7|[18574297]
    • 1051: XM005747
      Homo sapiens tachykinin receptor 2 (TACR2), mRNA
      gi|18574167|ref |XM005747.5|[18574167]
    • 1052: XM043613
      Homo sapiens glutamate receptor, ionotropic, delta 1 (GRID1), mRNA
      gi|18574031|ref|XM043613.4|[18574031]
    • 1053: XM028830
      Homo sapiens transient receptor potential cation channel, subfamily M, member 6
      (TRPM6), mRNA
      gi|18573768|ref|XM028830.3|[18573768]
    • 1054: XM095961
      Homo sapiens olfactory receptor, family 2, subfamily K, member 2 (OR2K2), mRNA
      gi|18573486|ref|XM095961.1|[18573486]
    • 1055: XM096286
      Homo sapiens receptor tyrosine kinase-like orphan receptor 2 (ROR2), mRNA
      gi|18573067|ref|XM096286.1|[18573067]
    • 1056: XM095815
      Homo sapiens olfactory receptor, family 1, subfamily J, member 5 (OR1J5), mRNA
      gi|18572435|ref|XM095815.1|[18572435]
    • 1057: XM095814
      Homo sapiens olfactory receptor, family 1, subfamily J, member 4 (OR1J4), mRNA
      gi|18572433|ref|XM095814.1|[18572433]
    • 1059: XM011695
      Homo sapiens leptin receptor overlapping transcript-like 1 (LEPROTL1), mRNA
      gi|18570296|ref|XM011695.3|[18570296]
    • 1061: XM088035
      Homo sapiens transient receptor potential cation channel, subfamily V, member 6
      (TRPV6), mRNA
      gi|18565882|ref|XM088035.1|[18565882]
    • 1062: XM004696
      Homo sapiens EphB6 (EPHB6), mRNA
      gi|18565881|ref|XM004696.5|[18565881]
    • 1063: XM096245
      Homo sapiens olfactory receptor, family 2, subfamily H, member 3 (OR2H3), mRNA
      gi|18564780|ref|XM096245.1|[18564780]
    • 1064: XM084200
      Homo sapiens olfactory receptor, family 11, subfamily A, member 1 (OR11A1), mRNA
      gi|18563692|ref|XM084200.1|[18563692]
    • 1065: XM084190
      Homo sapiens olfactory receptor, family 2, subfamily A, member 4 (OR2A4), mRNA
      gi|18563106|ref|XM084190.1|[18563106]
    • 1066: XM004341
      Homo sapiens opioid receptor, mu 1 (OPRM1), mRNA
      gi|18562969|ref|XM004341.6|[18562969]
    • 1067: XM084185
      Homo sapiens dopamine receptor D1 (DRD1), mRNA
      gi|18561988|ref|XM084185.1|[18561988]
    • 1069: XM049570
      Homo sapiens dioxin receptor repressor (AHRR), mRNA
      gi|18560847|ref|XM049570.4|[18560847]
    • 1070: XM084176
      Homo sapiens coagulation factor II (thrombin) receptor-like 1 (F2RL1), mRNA
      gi|18560787|ref|XM084176.1|[18560787]
    • 1071: NT029289
      Homo sapiens chromosome 5 working draft sequence segment
      gi|18560495|ref|NT029289.4|Hs529448[18560495]
    • 1072: XR000069
      Homo sapiens neuropeptide Y receptor Y6 (psuedogene) (NPY6R), misc RNA
      gi|18560235|ref|XR000069.1|[18560235]
    • 1073: NT025716
      Homo sapiens chromosome 5 working draft sequence segment
      gi|18560224|ref|NT025716.6|Hs525872[18560224]
    • 1074: XM094306
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), mRNA
      gi|18560222|ref|XM094306.1|[18560222]
    • 1075: XM096226
      Homo sapiens interleukin 7 receptor (IL7R), mRNA
      gi|18560176|ref|XM096226.1|[18560176]
    • 1076: XM031131
      Homo sapiens leukemia inhibitory factor receptor (LIFR), mRNA
      gi|18559952|ref|XM031131.2|[18559952]
    • 1077: XM011222
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2), mRNA
      gi|18559788|ref|XM011222.6|[18559788]
    • 1078: XM003519
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA
      gi|18558473|ref|XM003519.3|[18558473]
    • 1079: XM038446
      Homo sapiens melatonin receptor 1A (MTNR1A), mRNA
      gi|18558343|ref|XM038446.2|[18558343]
    • 1080: XM084160
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 2 (GABRA2), mRNA
      gi|18558328|ref|XM084160.1|[18558328]
    • 1081: XM011169
      Homo sapiens neuropeptide Y receptor Y2 (NPY2R), mRNA
      gi|18558281|ref|XM011169.3|[18558281]
    • 1082: XM044120
      Homo sapiens fibroblast growth factor receptor 3 (achondroplasia, thanatophoric
      dwarfism) (FGFR3), mRNA
      gi|18558241|ref|XM044120.2|[18558241]
    • 1083: NT030654
      Homo sapiens chromosome 4 working draft sequence segment
      gi|18557828|ref|NT030654.2|Hs430910[18557828]
    • 1084: NT030650
      Homo sapiens chromosome 4 working draft sequence segment
      gi|18557822|ref|NT030650.2|Hs430906[18557822]
    • 1085: XM011173
      Homo sapiens glutamate receptor, ionotropic, delta 2 (GRID2), mRNA
      gi|18557816|ref|XM011173.4|[18557816]
    • 1086: NT029955
      Homo sapiens chromosome 4 working draft sequence segment
      gi|18557687|ref|NT029955.3|Hs430210[18557687]
    • 1087: NT025693
      Homo sapiens chromosome 4 working draft sequence segment
      gi|18557505|ref|NT025693.3|Hs425849[18557505]
    • 1088: NM019841
      Homo sapiens transient receptor potential nation channel, subfamily V, member 5
      (TRPV5), mRNA
      gi|17505199|ref|NM019841.2|[17505199]
    • 1089: NT030778
      Homo sapiens chromosome 10 working draft sequence segment
      gi|17489667|ref|NT030778.1|Hs1031034[17489667]
    • 1090: NT010591
      Homo sapiens chromosome 16 working draft sequence segment
      gi|17487829|ref|NT010591.6|Hs1610748[17487829]
    • 1091: NT030889
      Homo sapiens chromosome X working draft sequence segment
      gi|17486981|ref|NT030889.1|HsX31145[17486981]
    • 1092: XM066104
      Homo sapiens G protein-coupled receptor 73-like 1 (GPR73L1), mA
      gi|17484462|ref|XM066104.1|[17484462]
    • 1093: XM056414
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4), mRNA
      gi|17483039|ref|XM056414.2|[17483039]
    • 1094: XM053166
      Homo sapiens somatostatin receptor-interacting protein (SSTRIP), mRNA
      gi|17482811|ref|XM053166.3|[17482811]
    • 1096: XM008489
      Homo sapiens acetyl LDL receptor; SREC=scavenger receptor expressed by endothelial cells (SREC), mRNA
      gi|17481055|ref|XM008489.7|[17481055]
    • 1097: XM044091
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 7 (CHRNA7), mRNA
      gi|17477913|ref|XM044091.2|[17477913]
    • 1098: NT010258
      Homo sapiens chromosome 15 working draft sequence segment
      gi|17477780|ref|NT010258.7|Hs1510415[17477780]
    • 1099: XM038336
      Homo sapiens neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), mRNA
      gi|17477779|ref|XM038336.2|[17477779]
    • 1101: XM027181
      Homo sapiens transient receptor potential cation channel, subfamily V, member 4
      (TRPV4), mRNA
      gi|17475007|ref|XM027181.2|[17475007]
    • 1102: XM047362
      Homo sapiens Glutamate receptor interacting protein (GRIP1), mRNA
      gi|17474492|ref|XM047362.3|[17474492]
    • 1104: XM006372
      Homo sapiens aryl hydrocarbon receptor interacting protein (AIP), mRNA
      gi|17472888|ref|XM006372.4|[17472888]
    • 1105: XM004893
      Homo sapiens receptor (calcitonin) activity modifying protein 3 (RAMP3), mRNA
      gi|17464777|ref|XM004893.4|[17464777]
    • 1107: XM004559
      Homo sapiens discoidin domain receptor family, member 1 (DDR1), mRNA
      gi|17464405|ref|XM004559.5|[17464405]
    • 1108: XM004237
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R), mRNA
      gi|17463326|ref|XM004237.4|[17463326]
    • 1109: XM051214
      Homo sapiens type 1 tumor necrosis factor receptor shedding aminopeptidase regulator (ARTS-1), mRNA
      gi|17462792|ref|XM051214.2|[17462792]
    • 1110: XM059645
      Homo sapiens neuropeptide Y receptor Y1 (NPY1R), mRNA
      gi|17462720|ref|XM059645.1|[17462720]
    • 1111: XM044493
      Homo sapiens cholecystokinin B receptor (CCKBR), mRNA
      gi|17461537|ref|XM044493.2|[17461537]
    • 1112: XM048562
      Homo sapiens interferon (alpha, beta and omega) receptor 1 (IFNAR1), mRNA
      gi|17460140|ref|XM048562.3|[17460140]
    • 1113: XM040307
      Homo sapiens low density lipoprotein receptor defect B complementing (LDLB), mRNA
      gi|17459160|ref|XM040307.2|[17459160]
    • 1114: XM046949
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2C (GRIN2C),
      mRNA
      gi|17457940|ref|XM046949.3|[17457940]
    • 1115: XM050937
      Homo sapiens galanin receptor 1 (GALR1), mRNA
      gi|17457665|ref|XM050937.2|[17457665]
    • 1116: XM058224
      Homo sapiens protein tyrosine phosphatase, receptor type, M (PTPRM), mRNA
      gi|17457059|ref|XM058224.1|[17457059]
    • 1117: XM059877
      Homo sapiens scavenger receptor cysteine rich domain containing, group B (4 domains) (SRCRB4D), mRNA
      gi|17452620|ref|XM059877.1|[17452620]
    • 1118: XM030074
      Homo sapiens corticotropin releasing hormone receptor 2 (CRHR2), mRNA
      gi|17451624|ref|XM030074.2|[17451624]
    • 1119: XM036899
      Homo sapiens paired immunoglobulin-like receptor alpha (PILR(ALPHA)), mRNA
      gi|17450024|ref|XM036899.2|[17450024]
    • 1120: XM040292
      Homo sapiens glutamate receptor, ionotropic, AMPA 1 (GRIA1), mRNA
      gi|17447971|ref|XM040292.3|[17447971]
    • 1121: XM003913
      Homo sapiens integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2), mRNA
      gi|17447767|ref|XM003913.5|[17447767]
    • 1122: XM052621
      Homo sapiens VPS10 domain receptor protein (SORCS2), mRNA
      gi|17447359|ref|XM052621.2|[17447359]
    • 1123: XM011186
      Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA
      gi|17446713|ref|XM011186.5|[17446713]
    • 1124: XM037260
      Homo sapiens coagulation factor II (thrombin) receptor (F2R), mRNA
      gi|17446698|ref|XM037260.3|[17446698]
    • 1125: XM068231
      Homo sapiens G protein-coupled receptor 78 (GPR78), mRNA
      gi|17446518|ref|XM068231.1|[17446518]
    • 1126: XM003896
      Homo sapiens growth hormone receptor (GHR), mRNA
      gi|17446516|ref|XM003896.5|[17446516]
    • 1127: XM003883
      Homo sapiens prolactin receptor (PRLR), mRNA
      gi|17446302|ref|XM003883.4|[17446302]
    • 1128: XM003423
      Homo sapiens toll-like receptor 6 (TLR6), mRNA
      gi|17443462|ref|XM003423.5|[17443462]
    • 1129: XM050674
      Homo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase)
      (KDR), mRNA
      gi|17443063|ref|XM050674.2|[17443063]
    • 1130: XM016537
      Homo sapiens low density lipoprotein receptor-related protein 8, apolipoprotein
      e receptor (LRP8), mRNA
      gi|17438001|ref|XM016537.4|[17438001]
    • 1131: XM050512
      Homo sapiens activin A receptor, type I (ACVR1), mRNA
      gi|17437640|ref|XM050512.3|[17437640]
    • 1132: XM011248
      Homo sapiens adrenergic, alpha-1B-, receptor (ADRA1B), mRNA
      gi|17437111|ref|XM011248.5|[17437111]
    • 1133: XM057299
      Homo sapiens very large G protein-coupled receptor 1 (VLGR1), mRNA
      gi|17436651|ref|XM057299.2|[17436651]
    • 1134: XM042825
      Homo sapiens luteinizing hormone/choriogonadotropin receptor (LHCGR), mRNA
      gi|17433844|ref|XM042825.3|[17433844]
    • 1135: XM039993
      Homo sapiens fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), mRNA
      gi|16188964|ref|XM039993.2|[16188964]
    • 1136: XM028642
      Homo sapiens integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5), mRNA
      gi|16186750|ref|XM028642.2|[16186750]
    • 1137: XM057337
      Homo sapiens cholinergic receptor, muscarinic 1 (CHRM1), mRNA
      gi|16184321|ref|XM057337.1|[16184321]
    • 1138: XM006447
      Homo sapiens interleukin 10 receptor, alpha (IL10RA), mRNA
      gi|16183626|ref|XM006447.5|[16183626]
    • 1139: XM057984
      Homo sapiens G protein-coupled receptor 51 (GPR51), mRNA
      gi|16181083|ref|XM057984.1|[16181083]
    • 1140: XM057452
      Homo sapiens toll-like receptor 4 (TLR4), mRNA
      gi|16179752|ref|XM057452.1|[16179752]
    • 1141: XM051505
      Homo sapiens opioid receptor, kappa 1 (OPRK1), mRNA
      gi|16179331|ref|XM051505.2|[16179331]
    • 1142: XM027651
      Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B),
      mRNA
      gi|16178146|ref|XM027651.2|[16178146]
    • 1144: XM028141
      Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 (KIR3DL2), mRNA
      gi|16176785|ref|XM028141.2|[16176785]
    • 1145: XM004872
      Homo sapiens atrophin-1 interacting protein 1; activin receptor interacting protein 1 (KIAA0705), mRNA
      gi|16175845|ref|XM004872.6|[16175845]
    • 1146: XM057372
      Homo sapiens tumor necrosis factor receptor superfamily, member 5 (TNFRSF5), mRNA
      gi|16174074|ref|XM057372.1|[16174074]
    • 1147: XM056391
      Homo sapiens BAFF receptor (BAFFR), mRNA
      gi|16168558|ref|XM056391.1|[16168558]
    • 1148: XM054949
      Homo sapiens transient receptor potential cation channel, subfamily V, member 2
      (TRPV2), mRNA
      gi|16165271|ref|XM054949.1|[16165271]
    • 1149: XM009219
      Homo sapiens endothelial differentiation, G-protein-coupled receptor 6 (EDG6),
      mRNA
      gi|16163259|ref|XM009219.5|[16163259]
    • 1150: XM057188
      Homo sapiens transient receptor potential cation channel, subfamily M, member 4
      (TRPM4), mRNA
      gi|16162857|ref|XM057188.1|[16162857]
    • 1151: XM033762
      Homo sapiens growth factor receptor-bound protein 10 (GRB10), mRNA
      gi|16162156|ref|XM033762.2|[16162156]
    • 1152: XM037256
      Homo sapiens protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2), mRNA
      gi|16162004|ref|XM037256.2|[16162004]
    • 1153: XM007662
      Homo sapiens transient receptor potential cation channel, subfamily M, member 1
      (TRPM1), mRNA
      gi|16161643|ref|XM007662.6|[16161643]
    • 1154: XM011327
      Homo sapiens hepatitis A virus cellular receptor 1 (HAVCR-1), mRNA
      gi|16159892|ref|XM011327.4|[16159892]
    • 1155: XM034331
      Homo sapiens endothelin receptor type A (EDNRA), mRNA
      gi|16158485|ref|XM034331.2|[16158485]
    • 1156: XM002212
      Homo sapiens follicle stimulating hormone receptor (FSHR), mRNA
      gi|16158251|ref|XM002212.4|[16158251]
    • 1157: XM003736
      Homo sapiens G protein-coupled receptor kinase 6 (GPRK6), mRNA
      gi|16157601|ref|XM003736.4|[16157601]
    • 1158: XM038350
      Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB),
      mRNA
      gi|16157449|ref|XM038350.21[16157449]
    • 1159: XM003789
      Homo sapiens colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog (CSF1R), mRNA
      gi|16157447|ref|XM003789.4|[16157447]
    • 1160: XM054659
      Homo sapiens olfactory receptor, family 3, subfamily A, member 3 (OR3A3), mRNA
      gi|15314104|ref|XM054659.1|[15314104]
    • 1161: XM054658
      Homo sapiens olfactory receptor, family 1, subfamily E, member 1 (OR1E1), mRNA
      gi|15314100|ref|XM054658.1|[15314100]
    • 1162: XM006275
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 1 (MS4A2), mRNA
      gi|15311761|ref|XM006275.4|[15311761]
    • 1163: XM012695
      Homo sapiens growth factor receptor-bound protein 7 (GRB7), mRNA
      gi|15310219|ref|XM012695.4|[15310219]
    • 1164: XM045812
      Homo sapiens G protein-coupled receptor 72 (GPR72), mRNA
      gi|15308293|ref|XM045812.2|[15308293]
    • 1165: XM033995
      Homo sapiens histamine H4 receptor (HRH4), mRNA
      gi|15305825|ref|XM033995.2|[15305825]
    • 1166: XM036978
      Homo sapiens tumor necrosis factor receptor superfamily, member 11a, activator
      of NFKB (TNFRSF11A), mRNA
      gi|15305343|ref|XM036978.2|[15305343]
    • 1167: XM015355
      Homo sapiens protein tyrosine phosphatase, receptor type, R (PTPRR), mRNA
      gi|15304370|ref|XM015355.2|[15304370]
    • 1168: XM006738
      Homo sapiens CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1 (CD36L1), mRNA
      gi|15303296|ref|XM006738.5|[15303296]
    • 1169: XM049255
      Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23A) (FCER2),
      mRNA
      gi|15302967|ref|XM049255.2|[15302967]
    • 1170: XM008930
      Homo sapiens coagulation factor II (thrombin) receptor-like 3 (F2RL3), mRNA
      gi|15302724|ref|XM008930.4|[15302724]
    • 1171: NT029418
      Homo sapiens chromosome 12 working draft sequence segment
      gi|15302021|ref|NT029418.1|Hs1229577[15302021]
    • 1173: XM054004
      Homo sapiens glutamate receptor, metabotropic 1 (GRM1), mRNA
      gi|15299786|ref|XM054004.1|[15299786]
    • 1174: XM046588
      Homo sapiens G protein-coupled receptor slt (SLT), mRNA
      gi|15299770|ref|XM046588.2|[15299770]
    • 1175: XM032592
      Homo sapiens VPS10 domain receptor protein SORCS 3 (SORCS3), mRNA
      gi|15299687|ref|XM032592.2|[15299687]
    • 1176: XM054157
      Homo sapiens G protein-coupled receptor 35 (GPR35), mRNA
      gi|15298180|ref|XM054157.1|[15298180]
    • 1177: XM042907
      Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), mRNA
      gi|15296528|ref|XM042907.2|[15296528]
    • 1178: XM033031
      Homo sapiens peroxisome proliferative activated receptor, gamma, coactivator 1
      (PPARGC1), mRNA
      gi|15295682|ref|XM033031.2|[15295682]
    • 1179: XM003708
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, pi (GABRP), mRNA
      gi|15294866|ref|XM003708.5|[15294866]
    • 1180: XM008189
      Homo sapiens CMRF35 leukocyte immunoglobulin-like receptor (CMRF35), mRNA
      gi|14785569|ref|XM008189.4|[14785569]
    • 1182: XM033305
      Homo sapiens lymphotoxin beta receptor (TNFR superfamily, member 3) (LTBR), mRNA
      gi|14784387|ref|XM033305.1|[14784387]
    • 1183: XM004350
      Homo sapiens cannabinoid receptor 1 (brain) (CNR1), mRNA
      gi|14783266|ref|XM004350.4|[14783266]
    • 1184: XM004285
      Homo sapiens peroxisome proliferative activated receptor, delta (PPARD), mRNA
      gi|14782955|ref|XM004285.4|[14782955]
    • 1185: XM042636
      Homo sapiens inositol 1,4,5-triphosphate receptor, type 3 (ITPR3), mRNA
      gi|14782869|ref|XM042636.1|[14782869]
    • 1187: XM050142
      Homo sapiens integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide) (ITGAM), mRNA
      gi|14779440|ref|XM050142.1|[14779440]
    • 1188: XM037826
      Homo sapiens adrenergic, beta, receptor kinase 2 (ADRBK2), mRNA
      gi|14777914|ref|XM037826.1|[14777914]
    • 1189: XM036497
      Homo sapiens olfactory receptor, family 1, subfamily F, member 2 (OR1F2), mRNA
      gi|14777865|ref|XM036497.1|[14777865]
    • 1190: XM036891
      Homo sapiens purinergic receptor P2X-like 1, orphan receptor (P2RXL1), mRNA
      gi|14777537|ref|XM036891.1|[14777537]
    • 1191: XM007986
      Homo sapiens apolipoprotein B48 receptor (APOB48R), mRNA
      gi|14777420|ref|XM007986.4|[14777420]
    • 1192: XM047456
      Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R), mRNA
      gi|14776693|ref|XM047456.1|[14776693]
    • 1193: XM030214
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A),
      mRNA
      gi|14776459|ref|XM030214.1|[14776459]
    • 1194: XM049959
      Homo sapiens chemokine (C-C motif) receptor 7 (CCR7), mRNA
      gi|14775963|ref|XM049959.1|[14775963]
    • 1196: XM048049
      Homo sapiens G protein-coupled receptor 56 (GPR56), mRNA
      gi|14775189|ref|XM048049.1|[14775189]
    • 1197: XM046488
      Homo sapiens glucagon receptor (GCGR), mRNA
      gi|14775175|ref|XM046488.1|[14775175]
    • 1198: XM040635
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 (P2RX1), mRNA
      gi|14774341|ref|XM040635.1|[14774341]
    • 1199: XM018451
      Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) (CHRNB1), mRNA
      gi|14773487|ref|XM018451.2|[14773487]
    • 1201: XM008432
  • Homo sapiens integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), mRNA
  • gi|14773206|ref|XM008432.4|[14773206]
    • 1202: XM047339
      Homo sapiens opiate receptor-like 1 (OPRL1), mRNA
      gi|14772199|ref|XM047339.1|[14772199]
    • 1203: XM006349
      Homo sapiens angiotensin receptor-like 1 (AGTRL1), mRNA
      gi|14771894|ref|XM006349.2|[14771894]
    • 1204: XM046182
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 3 (P2RX3), mRNA
      gi|14771633|ref|XM046182.1|[14771633]
    • 1205: XM006312
      Homo sapiens sortilin-related receptor, L (DLR class) A repeats-containing (SORL1), mRNA
      gi|14771251|ref|XM006312.4|[14771251]
    • 1206: XM012936
      Homo sapiens protein tyrosine phosphatase, receptor type, T (PTPRT), mRNA
      gi|14770881|ref|XM012936.3|[14770881]
    • 1207: XM040842
      Homo sapiens cullin 5 (CUL5), mRNA
      gi|14770334|ref|XM040842.1|[14770334]
    • 1208: XM045103
      Homo sapiens G protein coupled receptor interacting protein, complement-c1q tumor necrosis factor-related (ZSIG37), mRNA
      gi|14770190|ref|XM045103.1|[14770190]
    • 1209: XM040699
      Homo sapiens transient receptor potential cation channel, subfamily C, member 6
      (TRPC6), mRNA
      gi|14770156|ref|XM040699.1|[14770156]
    • 1210: XM040922
      Homo sapiens interleukin 13 receptor, alpha 2 (IL13RA2), mRNA
      gi|14769890|ref|XM040922.1|[14769890]
    • 1211: XM028854
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 4 (CHRNA4), mRNA
      gi|14769881|ref|XM028854.1|[14769881]
    • 1212: XM028783
      Homo sapiens opioid growth factor receptor (OGFR), mRNA
      gi|14769761|ref|XM028783.1|[14769761]
    • 1213: XM050577
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 7 (ILT11), mRNA
      gi|14769454|ref|XM050577.1|[14769454]
    • 1215: XM045929
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 4 (P2RX4), mRNA
      gi|14768232|ref|XM045929.1|[14768232]
    • 1216: XM006929
      Homo sapiens complement component 3a receptor 1 (C3AR1), mRNA
      gi|14765892|ref|XM006929.2|[14765892]
    • 1217: XM030897
      Homo sapiens angiotensin receptor 2 (AGTR2), mRNA
      gi|14765825|ref|XM030897.1|[14765825]
    • 1218: XM037563
      Homo sapiens G protein-coupled receptor 54 (GPR54), mRNA
      gi|14765555|ref|XM037563.1|[14765555]
    • 1219: XM045549
      Homo sapiens FGF receptor activating protein 1 (FRAG1), mRNA
      gi|4765112|ref|XM045549.1|[14765112]
    • 1220: XM045706
      Homo sapiens toll-like receptor 8 (TLR8), mRNA
      gi|14764423|ref|XM045706.1|[14764423]
    • 1221: XM013100
      Homo sapiens G protein-coupled receptor 34 (GPR34), mRNA
      gi|14764061|ref|XM013100.3|[14764061]
    • 1222: XM012862
      Homo sapiens cargo selection protein (mannose 6 phosphate receptor binding protein) (TIP47), mRNA
      gi|14764025|ref|XM012862.3|[14764025]
    • 1223: XM035037
      Homo sapiens low density lipoprotein receptor-related protein 4 (LRP4), mRNA
      gi|14763920|ref|XM035037.1|[14763920]
    • 1224: XM050707
      Homo sapiens activin A receptor type II-like 1 (ACVRL1), mRNA
      gi|14763806|ref|XM050707.1|[14763806]
    • 1225: XM036573
      Homo sapiens low density lipoprotein receptor-related protein 3 (LRP3), mRNA
      gi|14763070|ref|XM036573.1|[14763070]
    • 1226: XM012843
      Homo sapiens protein tyrosine phosphatase, receptor type, H (PTPRH), mRNA
      gi|14762603|ref|XM012843.3|[14762603]
    • 1227: XM006789
      Homo sapiens protein tyrosine phosphatase, receptor type, B (PTPRB), mRNA
      gi|14762249|ref|XM006789.4|[14762249]
    • 1229: XM034808
      Homo sapiens interleukin 1 receptor accessory protein-like 2 (IL1RAPL2), mRNA
      gi|14760985|ref|XM034808.1|[14760985]
    • 1230: XM006747
      Homo sapiens inositol 1,4,5-triphosphate receptor, type 2 (ITPR2), mRNA
      gi|14760648|ref|XM006747.4|[14760648]
    • 1231: XM015921
      Homo sapiens putative chemokine receptor; GTP-binding protein (HM74), mRNA
      gi|14760439|ref|XM015921.2|[14760439]
    • 1232: XM009008
      Homo sapiens egf-like module containing, mucin-like, hormone receptor-like sequence 1 (EMR1), mRNA
      gi|14759169|ref|XM009008.4|[14759169]
    • 1233: XM028274
      Homo sapiens prostaglandin 12 (prostacyclin) receptor (IP) (PTGIR), mRNA
      gi|14758807|ref|XM028274.1|[14758807]
    • 1234: XM007123
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A), mRNA
      gi|14757796|ref|XM007123.4|[14757796]
    • 1235: XM049518
      Homo sapiens intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
      (ICAM1), mRNA
      gi|14756651|ref|XM049518.1|[14756651]
    • 1236: XM049496
      Homo sapiens purinergic receptor P2Y, G-protein coupled, 11 (P2RY11), mRNA
      gi|14756601|ref|XM049496.1|[14756601]
    • 1237: XM007577
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 5 (CHRNA5), mRNA
      gi|14756537|ref|XM007577.2|[14756537]
    • 1238: XM006636
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B),
      mRNA
      gi|14756111|ref|XM006636.4|[14756111]
    • 1239: XM044309
      Homo sapiens poliovirus receptor (PVR), mRNA
      gi|14755769|ref|XM044309.1|[14755769]
    • 1240: XM004134
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1E (HTR1E), mRNA
      gi|14755675|ref|XM004134.4|[14755675]
    • 1241: XM033838
      Homo sapiens chemokine (C-C motif) receptor 6 (CCR6), mRNA
      gi|14755122|ref|XM033838.1|[14755122]
    • 1242: XM031082
      Homo sapiens formyl peptide receptor-like 1 (FPRL1), mRNA
      gi|14754918|ref|XM031082.1|[14754918]
    • 1243: XM028205
      Homo sapiens glucagon-like peptide 1 receptor (GLP1R), mRNA
      gi|14754205|ref|XM028205.1|[14754205]
    • 1244: XM051710
      Homo sapiens prostaglandin E receptor 2 (subtype EP2), 53 kD (PTGER2), mRNA
      gi|14753577|ref|XM051710.1|[14753577]
    • 1245: XM048918
      Homo sapiens met proto-oncogene (hepatocyte growth factor receptor) (MET), mRNA
      gi|14753543|ref|XM048918.1|[14753543]
    • 1246: XM045352
      Homo sapiens receptor-interacting serine-threonine kinase 2 (RIPK2), mRNA
      gi|14751723|ref|XM045352.1|[14751723]
    • 1247: XM049463
      Homo sapiens fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2,
      Pfeiffer syndrome) (FGFR1), mRNA
      gi|14750712|ref|XM049463.1|[14750712]
    • 1248: XM033240
      Homo sapiens leukotriene b4 receptor (chemokine receptor-like 1) (LTB4R), mRNA
      gi|14750696|ref|XM033240.1|[14750696]
    • 1249: XM046720
      Homo sapiens gamma-aminobutyric acid (GABA) receptor, rho 1 (GABRR1), mRNA
      gi|14750531|ref|XM046720.1|[14750531]
    • 1250: XM050434
      Homo sapiens interferon gamma receptor 1 (IFNGR1), mRNA
      gi|14750131|ref|XM050434.1|[14750131]
    • 1251: XM035832
      Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 3 (CHRNB3), mRNA
      gi|14749978|ref|XM035832.1|[14749978]
    • 1252: XM034142
      Homo sapiens CD36 antigen (collagen type I receptor, thrombospondin receptor) (CD36), mRNA
      gi|14749875|ref|XM034142.1|[14749875]
    • 1253: XM030066
      Homo sapiens growth hormone releasing hormone receptor (GHRHR), mRNA
      gi|14749610|ref|XM030066.1|[14749610]
    • 1254: XM007383
      Homo sapiens G protein-coupled receptor 68 (GPR68), mRNA
      gi|14748827|ref|XM007383.2|[14748827]
    • 1255: XM004117
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B), mRNA
      gi|14747779|ref|XM004117.2|[14747779]
    • 1256: XM036123
      Homo sapiens transient receptor potential cation channel, subfamily M, member 3
      (TRPM3), mRNA
      gi|14743665|ref|XM036123.1|[14743665]
    • 1257: XM011817
      Homo sapiens muscle, skeletal, receptor tyrosine kinase (MUSK), mRNA
      gi|14742818|ref|XM011817.3|[14742818]
    • 1258: XM044653
      Homo sapiens epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), mRNA
      gi|14741797|ref|XM044653.1|[14741797]
    • 1259: XM033529
      Homo sapiens G protein-coupled receptor 85 (GPR85), mRNA
      gi|14741568|ref|XM033529.1|[14741568]
    • 1260: XM011916
      Homo sapiens pancreatic polypeptide receptor 1 (PPYR1), mRNA
      gi|14740172|ref|XM011916.2|[14740172]
    • 1261: XM005486
      Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), mRNA
      gi|14740022|ref|XM005486.4|[14740022]
    • 1262: XM042740
      Homo sapiens region containing Sulfonylurea receptor; KIAA1674 (LOC142781), mRNA
      gi|14739341|ref|XM042740.1|[14739341]
    • 1263: XM045386
      Homo sapiens very low density lipoprotein receptor (VLDLR), mRNA
      gi|14736403|ref|XM045386.1|[14736403]
    • 1264: XM004002
      Homo sapiens hyaluronan-mediated motility receptor (RHAMM) (HMMR), mRNA
      gi|14734503|ref|XM004002.4|[14734503]
    • 1265: XM034451
      Homo sapiens olfactory receptor, family 7, subfamily A, member 120 (OR7E120), mRNA
      gi|14733406|ref|XM034451.1|[14733406]
    • 1266: XM029284
      Homo sapiens cholecystokinin A receptor (CCKAR), mRNA
      gi|14733138|ref|XM029284.1|[14733138]
    • 1267: XM052171
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 4 (HTR4), mRNA
      gi|14732310|ref|XM052171.1|[14732310]
    • 1268: XM042695
      Homo sapiens fibroblast growth factor receptor-like 1 (FGFRL1), mRNA
      gi|14728655|ref|XM042695.1|[14728655]
    • 1269: XM041933
      Homo sapiens Ig superfamily receptor LNIR (LNIR), mRNA
      gi|14723974|ref|XM041933.1|[14723974]
    • 1270: XM032738
      Homo sapiens glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man
      syndrome) (GLRA1), mRNA
      gi|14722750|ref|XM032738.1|[14722750]
    • 1271: XM032682
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 6 (GABRA6), mRNA
      gi|14722636|ref|XM032682.1|[14722636]
    • 1272: XM017228
      Homo sapiens low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) (LRP1), mRNA
      gi|13654580|ref|XM017228.1|[13654580]
    • 1273: XM008538
      Homo sapiens aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), mRNA
      gi|13653245|ref|XM008538.3|[13653245]
    • 1274: XM007046
      Homo sapiens vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR), mRNA
      gi|13653215|ref|XM007046.3|[13653215]
    • 1275: XM007751
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 3 (GABRB3), mRNA
      gi|13653090|ref|XM007751.3|[13653090]
    • 1276: XM007719
      Homo sapiens paired basic amino acid cleaving enzyme (furin, membrane associated
      receptor protein) (PACE), mRNA
      gi|1365250|ref|XM007719.2|[13652501]
    • 1277: XM010296
      Homo sapiens transient receptor potential cation channel, subfamily C, member 5
      (TRPC5), mRNA
      gi|13652451|ref|XM010296.2|[13652451]
    • 1278: XM006950
      Homo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A),
      mRNA
      gi|13652420|ref|XM006950.3|[13652420]
    • 1279: XM008206
      Homo sapiens receptor (calcitonin) activity modifying protein 2 (RAMP2), mRNA
      gi|13652390|ref|XM008206.3|[13652390]
    • 1280: XM013114
      Homo sapiens interleukin 1 receptor accessory protein-like 1 (IL1RAPL1), mRNA
      gi|13652318|ref|XM013114.2|[13652318]
    • 1281: XM015989
      Homo sapiens interleukin 9 receptor (IL9R), mRNA
      gi|13652206|ref|XM015989.1|[13652206]
    • 1282: XM006934
      Homo sapiens arginine vasopressin receptor 1A (AVPR1A), mRNA
      gi|13652044|ref|XM006934.3|[13652044]
    • 1283: XM012441
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 5 (GABRA5), mRNA
      gi|13651536|ref|XM012441.2|[13651536]
    • 1284: XM008193
      Homo sapiens putative receptor protein (PMI), mRNA
      gi|13650873|ref|XM008193.2|[13650873]
    • 1285: XM009108
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2D (GRIN2D),
      mRNA
      gi|13650682|ref|XM009108.3|[13650682]
    • 1286: XM015505
      Homo sapiens AXL receptor tyrosine kinase (AXL), mRNA
      gi|13650099|ref|XM015505.1|[13650099]
    • 1287: XM006145
      Homo sapiens dopamine receptor D4 (DRD4), mRNA
      gi|13647063|ref|XM006145.2|[13647063]
    • 1288: XM009803
      Homo sapiens transient receptor potential cation channel, subfamily M, member 2
      (TRPM2), mRNA
      gi|13646881|ref|XM009803.3|[13646881]
    • 1289: XM004030
      Homo sapiens adrenergic, beta-2-, receptor, surface (ADRB2), mRNA
      gi|13645597|ref|XM004030.2|[13645597]
    • 1290: XM011703
      Homo sapiens tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A),
      mRNA
      gi|13644652|ref|XM011703.2|[13644652]
    • 1291: XM003986
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), mRNA
      gi|13643024|ref|XM003986.2|[13643024]
    • 1292: XM004253
      Homo sapiens gamma-aminobutyric acid (GABA) receptor, rho 2 (GABRR2), mRNA
      gi|13642452|ref|XM004253.2|[13642452]
    • 1293: XM006233
      Homo sapiens glutamate receptor, ionotrophic, AMPA 4 (GRIA4), mRNA
      gi|13639643|ref|XM006233.3|[13639643]
    • 1294: XM005384
      Homo sapiens RAR-related orphan receptor B (RORB), mRNA
      gi|13639481|ref|XM005384.3|[13639481]
    • 1295: XM004988
      Homo sapiens aryl hydrocarbon receptor (AHR), mRNA
      gi|13631520|ref|XM004988.2|[13631520]
    • 1296: XM011364
      Homo sapiens lymphocyte antigen 95 (activating NK-receptor; NK-p44) (LY95), mRNA
      gi|3630600|ref|XM011364.2|[13630600]
    • 1297: XM009612
      Homo sapiens neurotensin receptor 1 (high affinity) (NTSR1), mRNA
      gi|13630500|ref|XM009612.2|[13630500]
    • 1298: XM003417
      Homo sapiens CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II) (CD36L2), mRNA
      gi|13630130|ref|XM003417.3|[13630130]
    • 1299: XM007817
      Homo sapiens tumor necrosis factor receptor superfamily, member 17 (TNFRSF17),
      mRNA
      gi|13627219|ref|XM007817.3|[13627219]
    • 1300: XM012949
      Homo sapiens complement component 1, q subcomponent, receptor 1 (C1QR1), mRNA
      gi|12742414|ref|XM012949.1|[12742414]
    • 1301: XM009594
      Homo sapiens somatostatin receptor 4 (SSTR4), mRNA
      gi|12742412|ref|XM009594.2|[12742412]
    • 1302: XM008512
      Homo sapiens vanilloid receptor subtype 1 (VR1), mRNA
      gi|12740624|ref|XM008512.2|[12740624]
    • 1303: XM006931
      Homo sapiens oxidised low density lipoprotein (lectin-like) receptor 1 (OLR1),
      mRNA
      gi|12737735|ref|XM006931.2|[12737735]
    • 1304: XM006933
      Homo sapiens C-type lectin-like receptor-1 (LOC51267), mRNA
      gi|12737731|ref|XM006933.2|[12737731]
    • 1305: XM004438
      Homo sapiens interleukin 20 receptor, alpha (IL20RA), mRNA
      gi|12732139|ref|XM004438.2|[12732139]
    • 1306: XM003692
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A (HTR1A), mRNA
      gi|12731011|ref|XM003692.2|[12731011]
    • 1307: XM010228
      Homo sapiens G protein-coupled receptor 50 (GPR50), mRNA
      gi|12719157|ref|XM010228.2|[12719157]
    • 1308: XM009082
      Homo sapiens low density lipoprotein receptor (familial hypercholesterolemia) (LDLR), mRNA
      gi|1525992|ref|XM009082.1|[11525992]
    • 1309: XM006296
      Homo sapiens cholinergic receptor, muscarinic 4 (CHRM4), mRNA
      gi|11437838|ref|XM006296.1|[11437838]
    • 1310: NT009784
      Homo sapiens chromosome 12 working draft sequence segment
      gi|11436706|ref|NT009784.1|Hs129941[11436706] 131I: XM003386
      Homo sapiens gonadotropin-releasing hormone receptor (GNRHR), mRNA
      gi|11435615|ref|XM003386.1|[11435615]
    • 1312: NT024131
      Homo sapiens chromosome 10 working draft sequence segment
      gi|11430625|ref|NT024131.1|Hs1024287[11430625]
    • 1313: XM009373
      Homo sapiens formyl peptide receptor-like 2 (FPRL2), mRNA
      gi|11426996|ref|XM009373.1|[11426996]
    • 1314: XM008520
      Homo sapiens cholinergic receptor, nicotinic, epsilon polypeptide (CHRNE), mRNA
      gi|11426945|ref|XM008520.1|[11426945]
    • 1315: XM009140
      Homo sapiens G protein-coupled receptor 4 (GPR4), mRNA
      gi|11425489|ref|XM009140.1|[11425489]
    • 1316: XM008279
      Homo sapiens adenosine A2b receptor (ADORA2B), mRNA
      gi|11425432|ref|XM008279.1|[11425432]
    • 1317: XM010321
      Homo sapiens glycine receptor, alpha 2 (GLRA2), mRNA
      gi|11421007|ref|XM010321.1|[11421007]
    • 1318: XM004808
      Homo sapiens taste receptor, type 2, member 4 (TAS2R4), mRNA
      gi|11420322|ref|XM004808.1|[11420322]
    • 1319: XM004807
      Homo sapiens taste receptor, type 2, member 5 (TAS2R5), mRNA
      gi|11420320|ref|XM004807.1|[11420320]
    • 1320: XM011092
      Homo sapiens glycine receptor, alpha 3 (GLRA3), mRNA
      gi|18556859|ref|XM011092.4|[18556859]
    • 1321: XM003324
      Homo sapiens transient receptor potential cation channel, subfamily C, member 3
      (TRPC3), mRNA
      gi|18556760|ref|XM003324.5|[18556760]
    • 1322: XM011068
      Homo sapiens macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
      (MST1R), mRNA
      gi|18556611|ref|XM011068.4|[18556611]
    • 1323: XM011064
      Homo sapiens protein tyrosine phosphatase, receptor type, G (PTPRG), mRNA
      gi|18556526|ref|XM011064.7|[18556526]
    • 1324: XM003207
      Homo sapiens glutamate receptor, metabotropic 2 (GRM2), mRNA
      gi|18556346|ref|XM003207.5|[18556346]
    • 1325: XM036436
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP), mRNA
      gi|18555803|ref|XM036436.4|[18555803]
    • 1326: XM031246
      Homo sapiens roundabout, axon guidance receptor, homolog 2 (Drosophila) (ROBO2),
      mRNA
      gi|18555796|ref|XM031246.2|[18555796]
    • 1327: XM003226
      Homo sapiens vasoactive intestinal peptide receptor 1 (VIPR1), mRNA
      gi|18555693|ref|XM003226.7|[18555693]
    • 1328: NT005824
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18555677|ref|NT005824.7|Hs35981[18555677]
    • 1329: XM093692
      Homo sapiens RYK receptor-like tyrosine kinase (RYK), mRNA
      gi|18555675|ref|XM093692.1|[18555675]
    • 1332: NT005564
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18555104|ref|NT005564.8|Hs35721[18555104]
    • 1333: XM010943
      Homo sapiens inositol 1,4,5-triphosphate receptor, type 1 (ITPR1), mRNA
      gi|18554594|ref|XM010943.7|[18554594]
    • 1334: XM052730
      Homo sapiens transferrin receptor (p90, CD71) (TFRC), mRNA
      gi|18553906|ref|XM052730.3|[18553906]
    • 1335: XM032666
      Homo sapiens calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) (CASR), mRNA
      gi|18553576|ref|XM032666.3|[18553576]
    • 1336: XM002686
      Homo sapiens interleukin 1 receptor, type I (IL1R1), mRNA
      gi|18553052|ref|XM002686.6|[18553052]
    • 1337: XM002596
      Homo sapiens protein tyrosine phosphatase, receptor type, N (PTPRN), mRNA
      gi|18552617|ref|XM002596.6|[18552617]
    • 1338: XM087110
      Homo sapiens macrophage receptor with collagenous structure (MARCO), mRNA
      gi|18552038|ref|XM087110.1|[18552038]
    • 1340: XM087047
      Homo sapiens G protein-coupled receptor 66 (GPR66), mRNA
      gi|18551251|ref|XM087047.1|[18551251]
    • 1341: XM086954
      Homo sapiens G protein-coupled receptor 45 (GPR45), mRNA
      gi|18549982|ref|XM086954.1|[18549982]
    • 1342: XM029434
      Homo sapiens toll-like receptor 5 (TLR5), mRNA
      gi|18549454|ref|XM029434.2|[18549454]
    • 1344: XM089355
      Homo sapiens LDL receptor adaptor protein (ARH), mRNA
      gi|18549097|ref|XM089355.1|[18549097]
    • 1346: XM086483
      Homo sapiens Fc fragment of IgG, low affinity IIa, receptor for (CD32) (FCGR2A),
      mRNA
      gi|18548731|ref|XM086483.1|[18548731]
    • 1347: XM046751
      Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),
      interacting protein (liprin), alpha 4 (PPFIA4), mRNA
      gi|18548679|ref|XM046751.3|[18548679]
    • 1348: XM001821
      Homo sapiens glutamate receptor, ionotropic, kainate 3 (GRIK3), mRNA
      gi|18548332|ref|XM001821.7|[18548332]
    • 1349: XM002205
      Homo sapiens colony stimulating factor 3 receptor (granulocyte) (CSF3R), mRNA
      gi|18548330|ref|XM002205.2|[18548330]
    • 1350: XM033690
      Homo sapiens protein tyrosine phosphatase, receptor type, U (PTPRU), mRNA
      gi|18548204|ref|XM033690.2|[18548204]
    • 1351: XM001795
      Homo sapiens lamin B receptor (LBR), mRNA
      gi|18548051|ref|XM001795.6|[18548051]
    • 1352: XM058179
      Homo sapiens natural killer cell receptor 2B4 (CD244), mRNA
      gi|18547600|ref|XM058179.3|[18547600]
    • 1353: XM086356
      Homo sapiens cannabinoid receptor 2 (macrophage) (CNR2), mRNA
      gi|18547399|ref|XM086356.1|[18547399]
    • 1354: XM001499
      Homo sapiens endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 (EDG1), mRNA
      gi|18547249|ref|XM001499.1|[18547249]
    • 1355: NT031737
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18547126|ref|NT031737.1|Hs131908[18547126]
    • 1356: XM010608
      Homo sapiens G-protein coupled receptor 88 (GPR88), mRNA
      gi|18547116|ref|XM010608.6|[18547116]
    • 1357: XM089029
      Homo sapiens olfactory receptor, family 2, subfamily L, member 2 (OR2L2), mRNA
      gi|18547000|ref|XM089029.1|[18547000]
    • 1358: XM089028
      Homo sapiens olfactory receptor, family 2, subfamily L, member 1 (OR2L1), mRNA
      gi|18546996|ref|XM089028.1|[18546996]
    • 1359: XM089016
      Homo sapiens olfactory receptor, family 1, subfamily C, member 1 (OR1C1), mRNA
      gi|18546895|ref|XM089016.1|[18546895]
    • 1360: XM001289
      Homo sapiens xenotropic and polytropic retrovirus receptor (XPR1), mRNA
      gi|18546688|ref|XM001289.7|[18546688]
    • 1361: XM049849
      Homo sapiens tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) (TNFRSF14), mRNA
      gi|18546661|ref|XM049849.3|[18546661]
    • 1362: XM001667
      Homo sapiens natural killer cell receptor, immunoglobulin superfamily member (BY55), mRNA
      gi|18546631|ref|XM001667.5|[18546631]
    • 1364: XM086285
      Homo sapiens leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6),
      mRNA
      gi|18546477|ref|XM086285.1|[18546477]
    • 1365: XM016748
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), mRNA
      gi|18546353|ref|XM016748.4|[18546353]
    • 1366: XM088942
      Homo sapiens olfactory receptor, family 2, subfamily M, member 4 (OR2M4), mRNA
      gi|18546222|ref|XM088942.1|[18546222]
    • 1367: XM086242
      Homo sapiens receptor tyrosine kinase-like orphan receptor 1 (ROR1), mRNA
      gi|18546174|ref|XM086242.1|[18546174]
    • 1368: XM086232
      Homo sapiens G protein-coupled receptor 61 (GPR61), mRNA
      gi|18546070|ref|XM086232.1|[18546070]
    • 1369: XM042739
      Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog,
      Drosophila) (CELSR2), mRNA
      gi|18546045|ref|XM042739.2|[18546045]
    • 1370: XM002008
      Homo sapiens complement component (3d/Epstein Barr virus) receptor 2 (CR2), mRNA
      gi|18545768|ref|XM002008.6|[18545768]
    • 1371: XM052013
      Homo sapiens polymeric immunoglobulin receptor (PIGR), mRNA
      gi|18545758|ref|XM052013.2|[18545758]
    • 1372: XM001320
      Homo sapiens low density lipoprotein receptor defect C complementing (LDLC), mRNA
      gi|18545223|ref|XM001320.4|[18545223]
    • 1373: NT030585
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18544898|ref|NT030585.2|Hs130841[18544898]
    • 1374: XM084053
      Homo sapiens complement component (3b/4b) receptor 1, including Knops blood group system (CR1), mRNA
      gi|18544845|ref|XM084053.1|[18544845]
    • 1376: XM039685
      Homo sapiens putative G-protein coupled receptor (SH120), mRNA
      gi|17488963|ref|XM039685.3|[17488963]
    • 1377: XM001687
      Homo sapiens adenosine A1 receptor (ADORA1), mRNA
      gi|17488879|ref|XM001687.5|[17488879]
    • 1378: XM002700
      Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 like (COX7A2L), mRNA
      gi|17462137|ref|XM002700.3|[17462137]
    • 1379: XM002673
      Homo sapiens calcitonin receptor-like (CALCRL), mRNA
      gi|17447546|ref|XM002673.5|[17447546]
    • 1380: XM001924
      Homo sapiens transforming growth factor, beta receptor III (betaglycan, 300 kD)
      (TGFBR3), mRNA
      gi|17446897|ref|XM001924.6|[17446897]
    • 1381: XM001744
      Homo sapiens tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), mRNA
      gi|17444362|ref|XM001744.6|[17444362]
    • 1382: XM054837
      Homo sapiens tumor necrosis factor receptor superfamily, member 1B, (TNFRSF1B),
      mRNA
      gi|17444359|ref|XM054837.2|[17444359]
    • 1383: XM037011
      Homo sapiens T-cell receptor interacting molecule (TRIM), mRNA
      gi|17438759|ref|XM037011.2|[17438759]
    • 1384: NT022773
      Homo sapiens chromosome 4 working draft sequence segment
      gi|17438611|ref|NT022773.6|Hs422929[17438611]
    • 1385: XM051522
      Homo sapiens G protein-coupled receptor (RDC1), mRNA
      gi|17437231|ref|XM051522.2|[17437231]
    • 1386: NT029249
      Homo sapiens chromosome 2 working draft sequence segment
      gi|17436701|ref|NT029249.2|Hs229408[17436701]
    • 1387: XM050043
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 4 (GABRA4), mRNA
      gi|17436698|ref|XM050043.2|[17436698]
    • 1388: XM001857
      Homo sapiens platelet-activating factor receptor (PTAFR), mRNA
      gi|17435918|ref|XM001857.3|[17435918]
    • 1389: XM001630
      Homo sapiens prostaglandin F receptor (FP) (PTGFR), mRNA
      gi|17434349|ref|XM001630.5|[17434349]
    • 1390: XM058183
      Homo sapiens activating NK receptor (KALI), mRNA
      gi|16165765|ref|XM058183.1|[16165765]
    • 1391: XM003177
      Homo sapiens oxytocin receptor (OXTR), mRNA
      gi|16164840|ref|XM003177.5|[16164840]
    • 1392: XM001778
      Homo sapiens ryanodine receptor 2 (cardiac) (RYR2), mRNA
      gi|16161568|ref|XM001778.6|[16161568]
    • 1393: XM039118
      Homo sapiens phospholipase A2 receptor 1, 180 kD (PLA2R1), mRNA
      gi|16160858|ref|XM039118.2|[16160858]
    • 1394: NT005791
      Homo sapiens chromosome 3 working draft sequence segment
      gi|16159942|ref|NT005791.5|Hs35948[16159942]
    • 1395: NT029941
      Homo sapiens chromosome 3 working draft sequence segment
      gi|16158541|ref|NT029941.1|Hs330196[16158541]
    • 1396: XM056760
      Homo sapiens tumor necrosis factor receptor superfamily, member 9 (TNFRSF9), mRNA
      gi|16158007|ref|XM056760.1|[16158007]
    • 1397: XM010871
      Homo sapiens adrenergic, alpha-2B-, receptor (ADRA2B), mRNA
      gi|16157882|ref|XM010871.5|[16157882]
    • 1398: XM055737
      Homo sapiens interleukin 6 receptor (IL6R), mRNA
      gi|16157271|ref|XM055737.1|[16157271]
    • 1399: XM043563
      Homo sapiens insulin receptor-related receptor (INSRR), mRNA
      gi|15299156|ref|XM043563.2|[15299156]
    • 1400: XM001466
      Homo sapiens protein tyrosine phosphatase, receptor type, F (PTPRF), mRNA
      gi|15299050|ref|XM001466.5|[15299050]
    • 1401: XM002888
      Homo sapiens activin A receptor, type IIB (ACVR2B), mRNA
      gi|15298060|ref|XM002888.3|[15298060]
    • 1402: XM049427
      Homo sapiens interleukin 5 receptor, alpha (IL5RA), mRNA
      gi|15297287|ref|XM049427.2|[15297287]
    • 1404: XM047502
      Homo sapiens chemokine (C-X3-C) receptor 1 (CX3CR1), mRNA
      gi|15295593|ref|XM047502.2|[15295593]
    • 1405: XM041048
      Homo sapiens chemokine (C-C motif) receptor 8 (CCR8), mRNA
      gi|15295589|ref|XM041048.2|[15295589]
    • 1406: XM052155
      Homo sapiens adenosine A3 receptor (ADORA3), mRNA
      gi|14739381|ref|XM052155.1|[14739381]
    • 1407: XM002926
      Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA
      gi|14736663|ref|XM002926.3|[14736663]
    • 1408: XM030397
      Homo sapiens chemokine (C-C motif) receptor 5 (CCR5), mRNA
      gi|14736645|ref|XM030397.1|[14736645]
    • 1409: XM040605
      Homo sapiens interleukin 17B receptor (IL17BR), mRNA
      gi|14735848|ref|XM040605.1|[14735848]
    • 1410: XM033199
      Homo sapiens growth hormone secretagogue receptor (GHSR), mRNA
      gi|14735283|ref|XM003199.4|[14735283]
    • 1411: XM041399
      Homo sapiens glutamate receptor, metabotropic 7 (GRM7), mRNA
      gi|14734683|ref|XM041399.1|[14734683]
    • 1412: XM039011
      Homo sapiens integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4), mRNA
      gi|14733147|ref|XM039011.1|[14733147]
    • 1413: XM033709
      Homo sapiens opioid receptor, delta 1 (OPRD1), mRNA
      gi|14732044|ref|XM033709.1|[14732044]
    • 1414: XM033469
      Homo sapiens transforming growth factor, beta receptor II (70-80 kD) (TGFBR2), mRNA
      gi|14732004|ref|XM033469.1|[14732004]
    • 1415: XM017782
      Homo sapiens ectodysplasin 1, anhidrotic receptor (EDAR), mRNA
      gi|14731094|ref|XM017782.2|[14731094]
    • 1416: XM002475
      Homo sapiens insulin receptor substrate 1 (IRS1), mRNA
      gi|14730385|ref|XM002475.4|[14730385]
    • 1417: XM051470
      Homo sapiens angiotensin receptor 1 (AGTR1), mRNA
      gi|14729512|ref|XM051470.1|[14729512]
    • 1418: XM001542
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D (HTR1D), mRNA
      gi|14726872|ref|XM001542.4|[14726872]
    • 1419: XM052382
      Homo sapiens histamine receptor H1 (HRH1), mRNA
      gi|14726259|ref|XM052382.1|[14726259]
    • 1420: XM032349
      Homo sapiens interleukin 22 receptor (IL22R), mRNA
      gi|14725224|ref|XM032349.1|[14725224]
    • 1421: XM002792
      Homo sapiens APMCF1 protein (APMCF1), mRNA
      gi|14720925|ref|XM002792.4|[14720925]
    • 1422: XM045070
      Homo sapiens immunoglobulin superfamily receptor translocation associated 2 (IRTA2), mRNA
      gi|14720460|ref|XM045070.1|[14720460]
    • 1423: XM045067
      Homo sapiens immunoglobulin superfamily receptor translocation associated 1 (IRTA1), mRNA
      gi|14720452|ref|XM045067.1|[14720452]
    • 1425: XM002685
      Homo sapiens interleukin 1 receptor-like 2 (IL1RL2), mRNA
      gi|12728885|ref|XM002685.2|[12728885]
    • 1426: XM002624
      Homo sapiens G protein-coupled receptor 75 (GPR75), mRNA
      gi|11430331|ref|XM002624.1|[11430331]
    • 1427: XM001907
      Homo sapiens G protein-coupled receptor 25 (GPR25), mRNA
      gi|11425714|ref|XM001907.1|[11425714]
    • 1428: XM001543
      Homo sapiens G protein-coupled receptor 52 (GPR52), mRNA
      gi|11423045|ref|XM001543.1|[11423045]
    • 1429: NM016113
      Homo sapiens transient receptor potential cation channel, subfamily V, member 2
      (TRPV2), mRNA
      gi|7706766|ref|NM016113.1|[7706766]
    • 1430: NM002837
      Homo sapiens protein tyrosine phosphatase, receptor type, B (PTPRB), mRNA
      gi|18491009|ref|NM002837.2|[18491009]
    • 1431: NM017625
      Homo sapiens intelectin (ITLN), mRNA
      gi|8923027|ref|NM017625.1|[8923027]
    • 1432: NM000651
      Homo sapiens complement component (3b/4b) receptor 1, including Knops blood group system (CR1), transcript variant S, mRNA
      gi|18490997|ref|NM000651.2|[18490997]
    • 1433: NM000573
      Homo sapiens complement component (3b/4b) receptor 1, including Knops blood group system (CR1), transcript variant F, mRNA
      gi|18490996|ref|NM000573.2|[18490996]
    • 1435: BC022501
      Homo sapiens, neurotensin receptor 2, clone MGC:26447 IMAGE:4792730, mRNA, complete cds
      gi|18490911|gb|BC022501.1)[18490911]
    • 1436: BC022447
      Homo sapiens, angiotensin receptor 1, clone MGC:25987 IMAGE:4799755, mRNA, complete cds
      gi|18490885|gb|BC022447.1|[18490885]
    • 1437: BC022317
      Homo sapiens, T cell receptor delta diversity 3, clone MGC:22624 IMAGE:4732634, mRNA, complete cds
      gi|18490613|gb|BC022317.1|[18490613]
    • 1438: BC022304
      Homo sapiens, receptor (calcitonin) activity modifying protein 3, clone MGC:22548 IMAGE:4717934, mRNA, complete cds
      gi|18490610|gb|BC022304.1|[18490610]
    • 1439: BC022496
      Homo sapiens, glutamate receptor, metabotropic 3, clone MGC:26392 IMAGE:4792430,
      mRNA, complete cds
      gi|18490393|gb|BC022496.1|[18490393]
    • 1440: BC022511
      Homo sapiens, endothelin receptor type A, clone MGC:26548 IMAGE:4812050, mRNA,
      complete cds
      gi|18490297|gb|BC022511.1|[18490297]
    • 1441: BC022502
      Homo sapiens, glycine receptor, beta, clone IMAGE:4792516, mRNA
      gi|18490294|gb|BC022502.1|[18490294]
    • 1442: BC022449
      Homo sapiens, gamma-aminobutyric acid (GABA) A receptor, beta 1, clone MGC:25991
      IMAGE:4797401, mRNA, complete cds
      gi|18490266|gb|BC022449.1|[18490266]
    • 1443: BC022295
      Homo sapiens, oxidised low density lipoprotein (lectin-like) receptor 1, clone
      MGC:22491 IMAGE:4722086, mRNA, complete cds
      gi|18490152|gb|BC022295.1|[18490152]
    • 1444: BC022279
      Homo sapiens, CMRF35 leukocyte immunoglobulin-like receptor, clone MGC:22395 IMAGE:4692025, mRNA, complete cds
      gi|18490142|gb|BC022279.1|[18490142]
    • 1448: AH011463
      Homo sapiens chromosome 7 map 7q22
      gi|18483169|gb|AH011463.1|SEG_AF461188S[18483169]
    • 1449: AF453828
      Homo sapiens G protein-coupled receptor affecting testicular descent (GREAT) mRNA, complete cds
      gi|18483167|gb|AF453828.1|[18483167]
    • 1450: AY072912
      Homo sapiens coxsackie-adenovirus-receptor isoform CAR4/7 (CXADR) mRNA, complete
      cds; alternatively spliced
      gi|18482481|gb|AY072912.1|[18482481]
    • 1451: AY072911
      Homo sapiens coxsackie-adenovirus-receptor isoform CAR3/7 (CXADR) mRNA, complete
      cds; alternatively spliced
      gi|18482479|gb|AY072911.1|[18482479]
    • 1452: AY072910
      Homo sapiens soluble coxsackie-adenovirus-receptor isoform CAR2/7 (CXADR) mRNA,
      complete cds; alternatively spliced
      gi|18482477|gb|AY072910.1|[18482477]
    • 1453: NM020399
      Homo sapiens PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10 (PIST), mRNA
      gi|9966876|ref|NM020399.1|[9966876]
    • 1454: NM017935
      Homo sapiens hypothetical protein FLJ20706 (BANK), mRNA
      gi|8923635|ref|NM017935.1|[8923635]
    • 1455: NM002438
      Homo sapiens mannose receptor, C type 1 (MRC1), mRNA
      gi|4505244|ref|NM002438.1|[4505244]
    • 1456: AF321913
      Homo sapiens histamine H3 receptor isoform 4 (HRH3) mRNA, complete cds, alternatively spliced
      gi|18461386|gb|AF321913.1|[18461386]
    • 1457: AF321912
      Homo sapiens histamine H3 receptor isoform 3 (HRH3) mRNA, complete cds, alternatively spliced
      gi|18461384|gb|AF321912.1|[18461384]
    • 1458: AF321911
      Homo sapiens histamine H3 receptor isoform 2 (HRH3) mRNA, complete cds, alternatively spliced
      gi|18461382|gb|AF321911.1|[18461382]
    • 1459: AF321910
      Homo sapiens histamine H3 receptor isoform 1 (HRH3) mRNA, complete cds, alternatively spliced
      gi|18461380|gb|AF321910.1|[18461380]
    • 1460: NM080841
      Homo sapiens protein tyrosine phosphatase, receptor type, A (PTPRA), transcript
      variant 3, mRNA
      gi|18450370|ref|NM080841.1|[18450370]
    • 1461: NM080840
      Homo sapiens protein tyrosine phosphatase, receptor type, A (PTPRA), transcript
      variant 2, mRNA
      gi|18450368|ref|NM080840.1|[18450368]
    • 1462: NM002836
      Homo sapiens protein tyrosine phosphatase, receptor type, A (PTPRA), transcript
      variant 1, mRNA
      gi|18450367|ref|NM002836.2|[18450367]
    • 1463: NM023915
      Homo sapiens G protein-coupled receptor 87 (GPR87), mRNA
      gi|13236505|ref|NM023915.1|[13236505]
    • 1464: NM003029
      Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), mRNA
      gi|10835030|ref|NM003029.1|[10835030]
    • 1465: NM018490
      Homo sapiens G protein-coupled receptor 48 (GPR48), mRNA
      gi|8923700|ref|NM018490.1|[8923700]
    • 1466: NM006065
      Homo sapiens signal-regulatory protein beta 1 (SIRPB1), mRNA
      gi|5174678|ref|NM006065.1|[5174678]
    • 1467: NM003667
      Homo sapiens G protein-coupled receptor 49 (GPR49), mRNA
      gi|4504378|ref|NM003667.1|[4504378]
    • 1468: NM080816
      Homo sapiens signal-regulatory protein beta 2 (SIRPB2), transcript variant 2, mRNA
      gi|18426908|ref|NM080816.1|[18426908]
    • 1469: NM018556
      Homo sapiens signal-regulatory protein beta 2 (SIRPB2), transcript variant 1, mRNA
      gi|18426907|ref|NM018556.2|[18426907]
    • 1470: NM080914
      Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant 3, mRNA
      gi|18426876|ref|NM080914.1|[18426876]
    • 1471: NM080913
      Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant 2, mRNA
      gi|18426874|ref|NM080913.1|[18426874]
    • 1472: NM080912
      Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant H2′, mRNA
      gi|18426872|ref|NM080912.1|[18426872]
    • 1473: NM001181
      Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant 1, mRNA
      gi|18426871|ref|NM001181.2|[18426871]
    • 1474: NM001671
      Homo sapiens asialoglycoprotein receptor 1 (ASGR1), mRNA
      gi|18426870|ref|NM001671.2|[18426870]
    • 1475: NM014978
      Homo sapiens VPS10 domain receptor protein SORCS 3 (SORCS3), mRNA
      gi|18379345|ref|NM014978.1|[18379345]
    • 1476: NM021625
      Homo sapiens transient receptor potential cation channel, subfamily V, member 4
      (TRPV4), mRNA
      gi|13699862|ref|NM021625.2|[13699862]
    • 1477: NM020960
      Homo sapiens G protein-coupled receptor 107 (GPR107), mRNA
      gi|13470087|ref|NM020960.1|[13470087]
    • 1478: NM021634
      Homo sapiens leucine-rich repeat-containing G protein-coupled receptor 7 (LGR7),
      mRNA
      gi|11056007|ref|NM021634.1|[11056007]
    • 1479: NM016179
      Homo sapiens transient receptor potential cation channel, subfamily C, member 4
      (TRPC4), mRNA
      gi|7706746|ref|NM016179.1|[7706746]
    • 1480: NM004621
      Homo sapiens transient receptor potential cation channel, subfamily C, member 6
      (TRPC6), mRNA
      gi|5730101|ref|NM004621.21[5730101]
    • 1481: NM003304
      Homo sapiens transient receptor potential cation channel, subfamily C, member 1
      (TRPC1), mRNA
      gi|4507684|ref|NM003304.1|[4507684]
    • 1485: NM016235
      Homo sapiens G protein-coupled receptor, family C, group 1, member B (GPRC5B),
      mRNA
      gi|7706450|ref|NM016235.1|[7706450]
    • 1487: AF024642
      Homo sapiens luteinizing hormone receptor gene, exon 1 and partial cds
      gi|2655113|gb|AF024642.1|AF024642[2655113]
    • 1488: NM007128
      Homo sapiens pre-B lymphocyte gene 1 (VPREB1), mRNA
      gi|18379350|ref|NM007128.2|[18379350]
    • 1489: NM020777
      Homo sapiens VPS10 domain receptor protein (SORCS2), mRNA
      gi|18379343|ref|NM020777.1|[18379343]
    • 1490: NM052918
      Homo sapiens VPS10 domain receptor protein SORCS 1 (SORCS1), mRNA
      gi|8379341|ref|NM052918.2|[18379341]
    • 1491: AF391164
      Homo sapiens osteoclast-associated receptor hOSCAR-M3 (OSCAR) mRNA, complete cds
      gi|18376830|gb|AF391164.1|AF391164[18376830]
    • 1492: AF391163
      Homo sapiens osteoclast-associated receptor hOSCAR-M2 (OSCAR) mRNA, complete cds
      gi|18376828|gb|AF391163.1|AF391163[18376828]
    • 1493: AF391162
      Homo sapiens osteoclast-associated receptor hOSCAR-M1 (OSCAR) mRNA, complete cds
      gi|18376826|gb|AF391162.1|AF391162[18376826]
    • 1494: AJ421783
      Homo sapiens mRNA for short transient receptor potential channel 7 (TRP7 gene)
      gi|18376628|emb|AJ421783.1|HSA421783[18376628]
    • 1497: AF410902
      Homo sapiens neurotrophin receptor tyrosine kinase type 2 (NTRK2) gene, promoter
      region and partial cds; alternatively spliced
      gi|18369868|gb|AF410902.1|AF410902[18369868]
    • 1498: AF410901
      Homo sapiens neurotrophin receptor tyrosine kinase type 2 truncated isoform (NTRK2) mRNA, complete cds; alternatively spliced
      gi|18369866|gb|AF410901.1|AF410901[18369866]
    • 1499: AF410900
      Homo sapiens neurotrophin receptor tyrosine kinase type 2 truncated isoform (NTRK2) mRNA, complete cds; alternatively spliced
      gi|18369864|gb|AF410900.1|AF410900[18369864]
    • 1500: AF410899
      Homo sapiens neurotrophin receptor tyrosine kinase type 2 (NTRK2) mRNA, complete
      cds; alternatively spliced
      gi|18369862|gb|AF410899.1|AF410899[18369862]
    • 1501: AF410898
      Homo sapiens clone DKFZp547L014 neurotrophin receptor tyrosine kinase type 2 truncated isoform (NTRK2) mRNA, partial cds; alternatively spliced
      gi|18369860|gb|AF410898.1|AF410898[18369860]
    • 1502: AY071830
      Homo sapiens interleukin 9 receptor (IL9R) gene, complete cds
      gi|18071671|gb|AY071830.1|[18071671]
    • 1503: AF421362
      Homo sapiens transient receptor potential channel 4 zeta splice variant (TRPC4)
      mRNA, complete cds; alternatively spliced
      gi|16517177|gb|AF421362.1|AF421362[16517177]
    • 1504: AF421361
      Homo sapiens transient receptor potential channel 4 eta splice variant (TRPC4)
      mRNA, complete cds; alternatively spliced
      gi|16517175|gb|AF421361.1|AF421361[16517175]
    • 1505: AF421360
      Homo sapiens transient receptor potential channel 4 epsilon splice variant (TRPC4) mRNA, complete cds; alternatively spliced
      gi|16517173|gb|AF421360.1|AF421360[16517173]
    • 1506: AF421359
      Homo sapiens transient receptor potential channel 4 beta splice variant (TRPC4)
      mRNA, complete cds; alternatively spliced
      gi|16517171|gb|AF421359.1|AF421359[16517171]
    • 1507: AF421358
      Homo sapiens transient receptor potential channel 4 alpha splice variant (TRPC4)
      mRNA, complete cds; alternatively spliced
      gi|16517169|gb|AF421358.1|AF421358[16517169]
    • 1508: AF359246
      Homo sapiens fibroblast growth factor receptor 4 variant mRNA, complete cds
      gi|13991617|gb|AF359246.1|AF359246[13991617]
    • 1509: NM022349
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 6A (MS4A6A), mRNA
      gi|11641258|ref|NM022349.1|[11641258]
    • 1510: NM006055
      Homo sapiens LanC lantibiotic synthetase component C-like 1 (bacterial) (LANCL1), mRNA
      gi|5174444|ref|NM006055.1|[5174444]
    • 1511: NM005716
      Homo sapiens regulator of G-protein signalling 19 interacting protein 1 (RGS19IP1), mRNA
      gi|5031714|ref|NM005716.1|[5031714]
    • 1512: NM003307
      Homo sapiens transient receptor potential cation channel, subfamily M, member 2
      (TRPM2), mRNA
      gi|4507688|ref|NM003307.1|[4507688]
    • 1513: NM003807
      Homo sapiens tumor necrosis factor (ligand) superfamily, member 14 (TNFSF14), mRNA
      gi|4507600|ref|NM003807.1|[4507600]
    • 1514: NM002984
      Homo sapiens small inducible cytokine A4 (SCYA4), mRNA
      gi|4506844|ref|NM002984.1|[4506844]
    • 1515: NM021181
      Homo sapiens 19A24 protein (CRACC), mRNA
      gi|12711663|ref|NM021181.2|[12711663]
    • 1516: BC021892
      Homo sapiens, CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II), clone MGC:9392 IMAGE:3872778, mRNA, complete cds
      gi|18257311|gb|BC021892.1|BC021892[18257311]
    • 1517: AF459285
      Homo sapiens 5-hydroxytryptamine receptor 3 subunit C (HTR3C) mRNA, complete cds
      gi|18251965|gb|AF459285.1|AF459285[18251965]
    • 1518: BC021553
      Homo sapiens, G protein coupled receptor interacting protein, complement-c1q tumor necrosis factor-related, clone MGC:31795 IMAGE:4622952, mRNA, complete cds
      gi|18204860|gb|BC021553.1|BC021553[18204860]
    • 1519: BC021195
      Homo sapiens, dopamine receptor D2, clone MGC:10521 IMAGE:3939741, mRNA, complete cds
      gi|18203702|gb|BC021195.1|BC021195[18203702]
    • 1520: BC020752
      Homo sapiens, Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor), clone MGC:22599 IMAGE:4722289, mRNA, complete cds
      gi|18089130|gb|BC020752.1|BC020752[18089130]
    • 1521: BC020614
      Homo sapiens, G protein-coupled receptor 84, clone MGC:22224 IMAGE:4279185, mRNA, complete cds
      gi|18089044|gb|BC020614.1|BC020614[18089044]
    • 1522: BC021104
      Homo sapiens, apelin; peptide ligand for APJ receptor, clone MGC:31846 IMAGE:4586949, mRNA, complete cds
      gi|18088893|gb|BC021104.1|BC021104[18088893]
    • 1523: BC020805
      Homo sapiens, leukocyte receptor cluster (LRC) member 5, clone MGC:23828 IMAGE:4277870, mRNA, complete cds
      gi|18088780|gb|BC020805.1|BC020805[18088780]
    • 1524: BC020742
      Homo sapiens, complement component 3a receptor 1, clone MGC:22570 IMAGE:4690283,
      mRNA, complete cds
      gi|18088764|gb|BC020742.1|BC020742[18088764]
    • 1525: BC020815
      Homo sapiens, putative receptor protein, clone MGC:23860 IMAGE:4296149, mRNA, complete cds
      gi|18088747|gb|BC020815.1|BC020815[18088747]
    • 1526: BC020768
      Homo sapiens, olfactory receptor, family 51, subfamily E, member 2, clone MGC:22638 IMAGE:4249775, mRNA, complete cds
      gi|18088468|gb|BC020768.1|BC020768[18088468]
    • 1527: BC020739
      Homo sapiens, interleukin 13 receptor, alpha 2, clone MGC:22566 IMAGE:4807603,
      mRNA, complete cds
      gi|18088440|gb|BC020739.1|BC020739[18088440]
    • 1528: BC020678
      Homo sapiens, G protein-coupled receptor 34, clone MGC:22389 IMAGE:4770479, mRNA, complete cds
      gi|18088371|gb|BC020678.1|BC020678[18088371]
    • 1529: BC020669
      Homo sapiens, advanced glycosylation end product-specific receptor, clone MGC:22357 IMAGE:4718076, mRNA, complete cds
      gi|18088362|gb|BC020669.1|BC020669[18088362]
    • 1530: BC020968
      Homo sapiens, chemokine (C-X-C motif), receptor 4 (fusin), clone MGC:9199 IMAGE:3846345, mRNA, complete cds
      gi|18088082|gb|BC020968.1|BC020968[18088082]
    • 1531: BC019610
      Homo sapiens, somatostatin receptor 2, clone MGC:24950 IMAGE:3875163, mRNA, complete cds
      gi|18043108|gb|BC019610.1|BC019610[18043108]
    • 1532: BC020079
      Homo sapiens, lamin B receptor, clone MGC:9041 IMAGE:3925138, mRNA, complete cds
      gi|18042833|gb|BC020079.1|BC020079[18042833]
    • 1715: NM001364
      Homo sapiens discs, large homolog 2, chapsyn-110 (Drosophila) (DLG2), mRNA
      gi|4557526|ref|NM001364.1|[4557526]
    • 1716: NM080744
      Homo sapiens scavenger receptor cysteine rich domain containing, group B (4 domains) (SRCRB4D), mRNA
      gi|18152778|ref|NM080744.1|[18152778]
    • 1717: AB063170
      Homo sapiens mRNA for BANK, complete cds
      gi|17646091|dbj|AB063170.1|AB063170[17646091]
    • 1718: NM022760
      Homo sapiens chromosome 20 open reading frame 81 (C20orf81), mRNA
      gi|16163672|ref|NM022760.2|[16163672]
    • 1719: NM032554
      Homo sapiens G protein-coupled receptor 81 (GPR81), mRNA
      gi|14211850|ref|NM032554.1|[14211850]
    • 1720: AB054004
      Homo sapiens DR5 gene for death receptor 5, promoter and partial cds
      gi|13429873|dbj|AB054004.1|AB054004[13429873]
    • 1721: NM000668
      Homo sapiens alcohol dehydrogenase IB (class I), beta polypeptide (ADH1B), mRNA
      gi|11496887|ref|NM000668.2|[11496887]
    • 1722: NM018697
      Homo sapiens LanC lantibiotic synthetase component C-like 2 (bacterial) (LANCL2), mRNA
      gi|8923910|ref|NM018697.1|[8923910]
    • 1723: NM016610
      Homo sapiens toll-like receptor 8 (TLR8), mRNA
      gi|7706147|ref|NM016610.1|[7706147]
    • 1725: NM015833
      Homo sapiens adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) (ADARB1),
      transcript variant DRABA2b, mRNA
      gi|7669476|ref|NM015833.1|[7669476]
    • 1727: NM007184
      Homo sapiens nischarin (NISCH), mRNA
      gi|6005787|ref|NM007184.1|[6005787]
    • 1728: NM000139
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 1 (MS4A2), mRNA
      gi|4503676|ref|NM000139.1|[4503676]
    • 1730: NM080681
      Homo sapiens collagen, type XI, alpha 2 (COL11A2), transcript variant 2, mRNA
      gi|18201918|ref|NM080681.1|[18201918]
    • 1731: NM080680
      Homo sapiens collagen, type XI, alpha 2 (COL11A2), transcript variant 1, mRNA
      gi|18201916|ref|NM080680.1|[18201916]
    • 1732: NM080679
      Homo sapiens collagen, type XI, alpha 2 (COL11A2), transcript variant 3, mRNA
      gi|18201914|ref|NM080679.1|[18201914]
    • 1733: NM006115
      Homo sapiens preferentially expressed antigen in melanoma (PRAME), mRNA
      gi|18201906|ref|NM006115.2|[18201906]
    • 1734: NM020526
      Homo sapiens EphA8 (EPHA8), mRNA
      gi|18201903|ref|NM020526.2|[18201903]
    • 1735: NM080818
      Homo sapiens G protein-coupled receptor 80 (GPR80), mRNA
      gi|18201871|ref|NM080818.1[18201871]
    • 1736: NM080817
      Homo sapiens G protein-coupled receptor 82 (GPR82), mRNA
      gi|18201869|ref|NM080817.1|[18201869]
    • 1737: AF400075
      Homo sapiens coagulation factor II (thrombin) receptor-like 1 (F2RL1) gene, complete cds
      gi|15021772|gb|AF400075.1|AF400075[15021772]
    • 1738: NM024021
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), mRNA
      gi|13430865|ref|NM024021.1|[13430865]
    • 1739: A1B066218
      Homo sapiens RYR1 gene for ryanodine receptor type1, partial cds, clone: 4-101
      gi|18181961|dbj|AB066218.1|AB066218[18181961]
    • 1740: AB066217
      Homo sapiens RYR1 gene for ryanodine receptor type1, partial cds, clone: 4-96
      gi|18181959|dbj|AB066217.1|AB066217[18181959]
    • 1741: NM021950
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of
      IgE, high affinity I, receptor for; beta polypeptide) (MS4A1), mRNA
      gi|11386186|ref|NM021950.1|[11386186]
    • 1742: NM012323
      Homo sapiens v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (MAFF), mRNA
      gi|6912489|ref|NM012323.1|[6912489]
    • 1743: AJ298292
      Homo sapiens mRNA for histamine receptor H4 (HRH4 gene)
      gi|18152452|emb|AJ298292.1|HSA298292[18152452]
    • 1744: AB070621
      Homo sapiens HTR4 gene for 5-hydroxytryptamine 4 receptor, promoter and exon 1
      gi|18149171|dbj|AB070621.1|AB070621[18149171]
    • 1745: AB070620
      Homo sapiens HTR4 mRNA for 5-hydroxytryptamine 4 receptor, partial cds
      gi|18149169|dbj|AB070620.1|AB070620[18149169]
    • 1746: AB050774
      Homo sapiens N27C7-4 gene, complete cds
      gi|8147104|dbj|AB050774.1|AB050774[18147104]
    • 1747: AB048946
      Homo sapiens PrRPR gene for prolactin releasing peptide receptor, complete cds
      gi|18147078|dbj|AB048946.1|AB048946[18147078]
    • 1748: NM030760
      Homo sapiens endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 (EDG8), mRNA
      gi|18141314|ref|NM030760.2|[18141314]
    • 1749: NM032556
      Homo sapiens interleukin-1 HY2 (IL1HY2), mRNA
      gi|18141307|ref|NM032556.2|[18141307]
    • 1750: AF459634
      Homo sapiens immunoglobulin superfamily receptor translocation associated 5 mRNA, complete cds
      gi|18140080|gb|AF459634.1|AF459634[18140080]
    • 1751: AF459633
      Homo sapiens immunoglobulin superfamily receptor translocation associated 4 mRNA, complete cds
      gi|18140078|gb|AF459633.1|AF459633[18140078]
    • 1752: AY046529
      Homo sapiens melanocortin 1 receptor mutant V122M (MC1R) gene, complete cds
      gi|1813824|gb|AY046529.1|[18138241]
    • 1753: AY046528
      Homo sapiens melanocortin 1 receptor mutant 140T (MC1R) gene, complete cds
      gi|18138239|gb|AY046528.1|[18138239]
    • 1754: AX338549
      Sequence 1 from Patent WO0185790
      gi|18128949|emb|AX338549.1|AX338549[18128949]
    • 1755: NM001745
      Homo sapiens calcium modulating ligand (CAMLG), mRNA
      gi|18105008|ref|NM001745.2|[18105008]
    • 1756: NM001128
      Homo sapiens adaptor-related protein complex 1, gamma 1 subunit (AP1G1), mRNA
      gi|18104997|ref|NM001128.2|[18104997]
    • 1757: NM080545
      Homo sapiens adaptor-related protein complex 1, gamma 2 subunit (AP1G2), transcript variant 2, mRNA
      gi|18104995|ref|NM080545.1|[18104995]
    • 1758: NM003917
      Homo sapiens adaptor-related protein complex 1, gamma 2 subunit (AP1G2), transcript variant 1, mRNA
      gi|18104994|ref|NM003917.2|[18104994]
    • 1759: AF459027
      Homo sapiens immunoglobulin superfamily receptor translocation associated protein 3 mRNA, complete cds
      gi|18092654|gb|AF459027.1|AF459027[18092654]
    • 1760: AY069943
      Homo sapiens TCP11b protein mRNA, complete cds
      gi|18091790|gb|AY069943.1|[18091790]
    • 1761: AY063126
      Homo sapiens Fc alpha/mu receptor mRNA, partial cds; alternatively spliced
      gi|18032043|gb|AY063126.1[18032043]
    • 1762: AY063125
      Homo sapiens Fc alpha/mu receptor mRNA, complete cds; alternatively spliced
      gi|18032041|gb|AY063125.1|[18032041]
    • 1763: AF395264
      Homo sapiens clone EIII48 bpVNTR55 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063763|gb|AF395264.1|AF395264[17063763]
    • 1764: AF395263
      Homo sapiens clone EIII48 bpVNTR54 dopamine receptor D4 (DRD4) gene, partial cds
      gi|1706376|gb|AF395263.1|AF395263[17063761]
    • 1765: AF395262
      Homo sapiens clone EIII48 bpVNTR53 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063759|gb|AF395262.1|AF395262[17063759]
    • 1766: AF395261
      Homo sapiens clone EIII48 bpVNTR52 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063757|gb|AF395261.1|AF395261[17063757]
    • 1767: AF395260
      Homo sapiens clone EIII48 bpVNTR51 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063755|gb|AF395260.1|AF395260[17063755]
    • 1768: AF395259
      Homo sapiens clone EIII48 bpVNTR50 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063753|gb|AF395259.1|AF395259[17063753]
    • 1769: AF395258
      Homo sapiens clone EIII48 bpVNTR49 dopamine receptor D4 (DRD4) gene, partial cds
      gi|1706375|gb|AF395258.1|AF395258[17063751]
    • 1770: AF395257
      Homo sapiens clone EIII48 bpVNTR48 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063749|gb|AF395257.1|AF395257[17063749]
    • 1771: AF395256
      Homo sapiens clone EIII48 bpVNTR47 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063747|gb|AF395256.1|AF395256[17063747]
    • 1772: AF395255
      Homo sapiens clone EIII48 bpVNTR46 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063745|gb|AF395255.1|AF395255[17063745]
    • 1773: AF395254
      Homo sapiens clone EIII48 bpVNTR45 dopamine receptor D4 (DRD4) gene, partial cds
      gi|7063743|gb|AF395254.1|AF395254[17063743]
    • 1774: AF395253
      Homo sapiens clone EIII48 bpVNTR44 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063741|gb|AF395253.1|AF395253[17063741]
    • 1775: AF395252
      Homo sapiens clone EIII48 bpVNTR43 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063739|gb|AF395252.1|AF395252[17063739]
    • 1776: AF395251
      Homo sapiens clone EIII48 bpVNTR42 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063737|gb|AF395251.1|AF395251[17063737]
    • 1777: AF395250
      Homo sapiens clone EIII48 bpVNTR41 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063735|gb|AF395250.1|AF395250[17063735]
    • 1778: AF395249
      Homo sapiens clone EIII48 bpVNTR40 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063733|gb|AF395249.1|AF395249[17063733]
    • 1779: AF395248
      Homo sapiens clone EIII48 bpVNTR39 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063731|gb|AF395248.1|AF395248[17063731]
    • 1780: AF395247
      Homo sapiens clone EIII48 bpVNTR38 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063729|gb|AF395247.1|AF395247[17063729]
    • 1781: AF395246
      Homo sapiens clone EIII48 bpVNTR37 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063727|gb|AF395246.1|AF395246[17063727]
    • 1782: AF395245
      Homo sapiens clone EIII48 bpVNTR36 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063725|gb|AF395245.1|AF395245[17063725]
    • 1783: AF395244
      Homo sapiens clone EIII48 bpVNTR35 dopamine receptor D4 (DRD4) gene, partial cds
      gi|7063723|gb|AF395244.1|AF395244[17063723]
    • 1784: AF395243
      Homo sapiens clone EIII48 bpVNTR34 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063721|gb|AF395243.1|AF395243[17063721]
    • 1785: AF395242
      Homo sapiens clone EIII48 bpVNTR33 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063719|gb|AF395242.1|AF395242[17063719]
    • 1786: AF395241
      Homo sapiens clone EIII48 bpVNTR32 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063717|gb|AF395241.1|AF395241[17063717]
    • 1787: AF395240
      Homo sapiens clone EIII48 bpVNTR31 dopamine receptor D4 (DRD4) gene, partial cds
      gi|7063715|gb|AF395240.1|AF395240[17063715]
    • 1788: AF395239
      Homo sapiens clone EIII48 bpVNTR30 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063713|gb|AF395239.1|AF395239[17063713]
    • 1789: AF395238
      Homo sapiens clone EIII48 bpVNTR29 dopamine receptor D4 (DRD4) gene, partial cds
      gi|1706371|gb|AF395238.1|AF395238[17063711]
    • 1790: AF395237
      Homo sapiens clone EIII48 bpVNTR28 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063709|gb|AF395237.1|AF395237[17063709]
    • 1791: AF395236
      Homo sapiens clone EIII48 bpVNTR27 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063707|gb|AF395236.1|AF395236[17063707]
    • 1792: AF395235
      Homo sapiens clone EIII48 bpVNTR26 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063705|gb|AF395235.1|AF395235[17063705]
    • 1793: AF395234
      Homo sapiens clone EIII48 bpVNTR25 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063703|gb|AF395234.1|AF395234[17063703]
    • 1794: AF395233
      Homo sapiens clone EIII48 bpVNTR24 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063701|gb|AF395233.1|AF395233[17063701]
    • 1795: AF395232
      Homo sapiens clone EIII48 bpVNTR23 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063699|gb|AF395232.1|AF395232[17063699]
    • 1796: AF395231
      Homo sapiens clone EIII48 bpVNTR22 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063697|gb|AF395231.1|AF395231[17063697]
    • 1797: AF395230
      Homo sapiens clone EIII48 bpVNTR21 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063695|gb|AF395230.1|AF395230[17063695]
    • 1798: AF395229
      Homo sapiens clone EIII48 bpVNTR20 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063693|gb|AF395229.1|AF395229[17063693]
    • 1799: AF395228
      Homo sapiens clone EIII48 bpVNTR19 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063691|gb|AF395228.1|AF395228[17063691]
    • 1800: AF395227
      Homo sapiens clone EIII48 bpVNTR18 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063689|gb|AF395227.1|AF395227[170636891]
    • 1801: AF395226
      Homo sapiens clone EIII48 bpVNTR17 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063687|gb|AF395226.1|AF395226[17063687]
    • 1802: AF395225
      Homo sapiens clone EIII48 bpVNTR16 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063685|gb|AF395225.1|AF395225[17063685]
    • 1803: AF395224
      Homo sapiens clone EIII48 bpVNTR15 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063683|gb|AF395224.1|AF395224[17063683]
    • 1804: AF395223
      Homo sapiens clone EIII48 bpVNTR14 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063681|gb|AF395223.1|AF395223[17063681]
    • 1805: AF395222
      Homo sapiens clone EIII48 bpVNTR13 dopamine receptor D4 (DRD4) gene, partial cds
      gi|7063679|gb|AF395222.1|AF395222[17063679]
    • 1806: AF395221
      Homo sapiens clone EIII48 bpVNTR12 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063677|gb|AF395221.1|AF395221[17063677]
    • 1807: AF395220
      Homo sapiens clone EIII48 bpVNTR11 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063675|gb|AF395220.1|AF395220[17063675]
    • 1808: AF395219
      Homo sapiens clone EIII48 bpVNTR10 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063673|gb|AF395219.1|AF395219[17063673]
    • 1809: AF395218
      Homo sapiens clone EIII48 bpVNTR9 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063671|gb|AF395218.1|AF395218[17063671]
    • 1810: AF395217
      Homo sapiens clone EIII48 bpVNTR8 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063669|gb|AF395217.1|AF395217[17063669]
    • 1811: AF395216
      Homo sapiens clone EIII48 bpVNTR7 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063667|gb|AF395216.1|AF395216[17063667]
    • 1812: AF395215
      Homo sapiens clone EIII48 bpVNTR6 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063665|gb|AF395215.1|AF395215[17063665]
    • 1813: AF395214
      Homo sapiens clone EIII48 bpVNTR5 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063663|gb|AF395214.1|AF395214[17063663]
    • 1814: AF395213
      Homo sapiens clone EIII48 bpVNTR4 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063661|gb|AF395213.1|AF395213[17063661]
    • 1815: AF395212
      Homo sapiens clone EIII48 bpVNTR3 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063659|gb|AF395212.1|AF395212[17063659]
    • 1816: AF395211
      Homo sapiens clone EIII48 bpVNTR2 dopamine receptor D4 (DRD4) gene, partial cds
      gi|17063657|gb|AF395211.1|AF395211[17063657]
    • 1817: AF395210
      Homo sapiens clone EIII48 bpVNTR1 dopamine receptor D4 (DRD4) gene, partial cds
      gi|7063655|gb|AF395210.1|AF395210[17063655]
    • 1818: AF258342
      Homo sapiens biogenic amine receptor-like protein mRNA, complete cds
      gi|15428321|gb|AF258342.1|AF258342[15428321]
    • 1819: AJ278982
      Homo sapiens mRNA for 5-hydroxytryptamine4 receptor (HTR4 gene), splice variant
      h5-HT4(n)
      gi|12274905|emb|AJ278982.1|HSA278982[12274905]
    • 1820: AJ278981
      Homo sapiens mRNA for 5-hydroxytryptamine4 receptor (HTR4 gene), splice variant
      h5-HT4(g)
      gi|12274903|emb|AJ278981.1|HSA278981[12274903]
    • 1821: AJ278980
      Homo sapiens mRNA for 5-hydroxytryptamine4 receptor (HTR4 gene), splice variant
      h5-HT4(b)
      gi|12274901|emb|AJ278980.1|HSA278980[12274901]
    • 1822: AJ278979
      Homo sapiens mRNA for 5-hydroxytryptamine4 receptor (HTR4 gene), splice variant
      h5-HT4(a)
      gi|12274899|emb|AJ278979.1|HSA278979[12274899]
    • 1823: NM014555
      Homo sapiens transient receptor potential cation channel, subfamily M, member 5
      (TRPM5), mA
      gi|11225265|ref|NM014555.1|[11225265]
    • 1824: AF200627
      Homo sapiens putative catecholamine receptor gene, complete cds
      gi|10441576|gb|AF200627.1|AF200627[10441576]
    • 1825: AF257789
      Homo sapiens urokinase-type plasminogen activator receptor mRNA, partial cds
      gi|8050814|gb|AF257789.1|AF257789[8050814]
    • 1826: NM002335
      Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5), mRNA
      gi|4505018|ref|NM002335.1|[4505018]
    • 1827: Y00508
      H. sapiens M1 gene for muscarinic acetylcholine receptor
      gi|297405|emb|Y00508.1|HSMIMAR[297405]
    • 1828: AF457599
      Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) gene, KIR3DL1-NKB1-like allele, promoter region and exon 1
      gi|18087432|gb|AF457599.1|AF457599[18087432]
    • 1829: AF457598
      Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) gene, KIR3DL1-NKB1-like allele, promoter region and exon 1
      gi|18087431|gb|AF457598.1|AF457598[18087431]
    • 1830: AF457597
      Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) gene, KIR3DL1-NKAT3-like allele, promoter region and exon 1
      gi|18087430|gb|AF457597.1|AF457597[18087430]
    • 1831: AJ312755
      Homo sapiens mRNA for scavenger receptor cysteine-rich protein SRCRB-S4D, (SRCRB-S4D gene)
      gi|18073905|emb|AJ312755.1|HSA312755[18073905]
    • 1832: AF331842
      Homo sapiens SPPR-2 mRNA, complete cds, alternatively spliced
      gi|18033260|gb|AF331842.1|AF331842[18033260]
    • 1833: AF331841
      Homo sapiens SPPR-1 mRNA, complete cds, alternatively spliced
      gi|18033258|gb|AF331841.1|AF331841[18033258]
    • 1834: AF331840
      Homo sapiens SPPR mRNA, complete cds, alternatively spliced
      gi|18033256|gb|AF331840.1|AF331840[18033256]
    • 1835: AF284756
      Homo sapiens VPS10 domain receptor S or CS mRNA, complete cds
      gi|18032274|gb|AF284756.1|AF284756[18032274]
    • 1836: AF328684
      Homo sapiens Fc-epsilon receptor III mRNA, complete cds
      gi|8028292|gb|AF328684.1|AF328684[18028292]
    • 1837: AY029413
      Homo sapiens interleukin-1 receptor antagonist-like FIL1 theta (FIL1-theta) mRNA, complete cds
      gi|18025343|gb|AY029413.1|[18025343]
    • 1838: AF126470
      Homo sapiens KOR-3D (KOR-3) mRNA, complete cds
      gi|18000078|gb|AF126470.1|AF126470[18000078]
    • 1839: AF435925
      Homo sapiens very large G protein-coupled receptor 1b (VLGR1) mRNA, complete cds
      gi|16904207|gb|AF435925.1|AF435925[16904207]
    • 1840: G67431
      D7S3125 GRB10 Homo sapiens STS genomic, sequence tagged site
      gi|12025489|gb|G67431.1|G67431[12025489]
    • 1841: AF260136
      Homo sapiens NK cell receptor D (NKG2-D) mRNA, NKG2-D*03 allele, complete cds
      gi|9295444|gb|AF260136.1|AF260136[9295444]
    • 1842: AF260135
      Homo sapiens NK cell receptor D (NKG2-D) mRNA, NKG2-D*02 allele, complete cds
      gi|9295442|gb|AF260135.1|AF260135[9295442]
    • 1843: AF260134
      Homo sapiens NK cell receptor C (NKG2-C) mRNA, NKG2-C*02 allele, complete cds
      gi|9295440|gb|AF260134.1|AF260134[9295440]
    • 1844: NM015891
      Homo sapiens pre-mRNA splicing factor 17 (PRP17), mRNA
      gi|7706656|ref|NM015891.1|[7706656]
    • 1845: L12397
      Homo sapiens Dopamine D4 receptor (DRD4) gene, partial cds
      gi|291947|gb|L12397.1|HUMD4G[291947]
    • 1846: NM019888
      Homo sapiens melanocortin 3 receptor (MC3R), mRNA
      gi|17986278|ref|NM019888.2|[17986278]
    • 1847: NM000795
      Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA
      gi|17986271|ref|NM000795.2|[17986271]
    • 1848: NM016574
      Homo sapiens dopamine receptor D2 (DRD2), transcript variant 2, mRNA
      gi|17986269|ref|NM016574.2|[17986269]
    • 1849: AY070269
      Homo sapiens hypocretin receptor 1 (HCRTR1) gene, complete cds
      gi|17979217|gb|AY070269.1|[17979217]
    • 1850: NM052945
      Homo sapiens BAFF receptor (BAFFR), mRNA
      gi|17978517|ref|NM052945.2|[17978517]
    • 1851: NM054026
      Homo sapiens CCR4—NOT transcription complex, subunit 7 (CNOT7), transcript variant 2, mRNA
      gi|17978499|ref|NM054026.1|[17978499]
    • 1852: NM013354
      Homo sapiens CCR4—NOT transcription complex, subunit 7 (CNOT7), transcript variant 1, mRNA
      gi|17978498|ref|NM013354.3|[17978498]
    • 1853: NM004444
      Homo sapiens EphB4 (EPHB4), mRNA
      gi|17975769|ref|NM004444.2|[17975769]
    • 1854: NM004443
      Homo sapiens EphB3 (EPHB3), mRNA
      gi|17975767|ref|NM004443.2|[17975767]
    • 1855: NM004442
      Homo sapiens EphB2 (EPHB2), transcript variant 1, mRNA
      gi|17975766|ref|NM004442.2|[17975766]
    • 1856: NM017449
      Homo sapiens EphB2 (EPHB2), transcript variant 2, mRNA
      gi|17975764|ref|NM017449.1|[17975764]
    • 1857: BC019278
      Homo sapiens, cargo selection protein (mannose 6 phosphate receptor binding protein), clone MGC:3816 IMAGE:2905275, mRNA, complete cds
      gi|17939468|gb|BC019278.1|BC019278[17939468]
    • 1858: NM080387
      Homo sapiens C-type lectin-like receptor (CLEC-6), mRNA
      gi|17933769|ref|NM080387.1|[17933769]
    • 1859: NM007200
      Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13), mRNA
      gi|17933491|ref|NM007200.1|[17933491]
    • 1861: AF373878
      Homo sapiens herpesvirus entry mediator (TNFRSF14) mRNA, TNFRSF14-V241I allele,
      complete cds
      gi|17901872|gb|AF373878.1|AF373878[17901872]
    • 1862: AF373877
      Homo sapiens herpesvirus entry mediator (TNFRSF14) mRNA, TNFRSF14-R17K allele,
      complete cds
      gi|17901869|gb|AF373877.1|AF373877[17901869]
    • 1863: AF373876
      Homo sapiens nectin-1 (PVRL1) gene, PVRL1-R199W allele, partial cds
      gi|17901866|gb|AF373876.1|AF373876[17901866]
    • 1864: AY065844
      Homo sapiens truncated receptor tyrosine kinase TrkC mRNA, partial cds
      gi|17887448|gb|AY065844.1|[17887448]
    • 1865: AY062295
      Homo sapiens prolactin receptor (PRLR) mRNA, partial cds; alternatively spliced
      gi|7887307|gb|AY062295.1|[17887307]
    • 1866: NM078474
      Homo sapiens BBP-like protein 2 (BLP2), transcript variant 1, mRNA
      gi|17865799|ref|NM078474.1|[17865799]
    • 1867: NM025141
      Homo sapiens BBP-like protein 2 (BLP2), transcript variant 2, mRNA
      gi|17865798|ref|NM025141.2|[17865798]
    • 1868: NM078473
      Homo sapiens BBP-like protein 1 (BLP1), transcript variant 1, mRNA
      gi|17865796|ref|NM078473.1|[17865796]
    • 1869: NM020749
      Homo sapiens AT2 receptor-interacting protein 1 (ATIP1), mRNA
      gi|17865631|ref|NM020749.1|[17865631]
    • 1870: NM002088
      Homo sapiens glutamate receptor, ionotropic, kainate 5 (GRIK5), mRNA
      gi|17864085|ref|NM002088.2|[17864085]
    • 1871: AY064474
      Homo sapiens interleukin 21 receptor (IL21R) gene, complete cds
      gi|17863086|gb|AY064474.1|[17863086]
    • 1872: AY036093
      Homo sapiens lysyl oxidase-like 4 mRNA, complete cds
      gi|1786137|gb|AY036093.1|[17861371]
    • 1873: AF369653
      Homo sapiens corticotropin releasing hormone receptor variant 1 g (CRHR1) mRNA,
      partial cds, alternatively spliced
      gi|17834100|gb|AF369653.1|AF369653[17834100]
    • 1874: AF369652
      Homo sapiens corticotropin releasing hormone receptor variant lf (CRHR1) mRNA,
      partial cds, alternatively spliced
      gi|17834097|gb|AF369652.1|AF369652[17834097]
    • 1875: AF369651
      Homo sapiens corticotropin releasing hormone receptor variant le (CRHRL) mRNA,
      partial cds, alternatively spliced
      gi|17834094|gb|AF369651.1|AF369651[17834094]
    • 1876: NM001239
      Homo sapiens cyclin H(CCNH), mRNA
      gi|17738313|ref|NM001239.2|[17738313]
    • 1877: NM014286
      Homo sapiens frequenin homolog (Drosophila) (FREQ), mRNA
      gi|17738307|ref|NM014286.2|[17738307]
    • 1878: NM006650
      Homo sapiens complexin 2 (CPLX2), mRNA
      gi|17738306|ref|NM006650.2|[17738306]
    • 1879: NM006651
      Homo sapiens complexin 1 (CPLX1), mRNA
      gi|17738305|ref|NM006651.2|[17738305]
    • 1880: AF416558
      Homo sapiens N-methyl-D-aspartate receptor 3A (GRIN3A) mRNA, complete cds
      gi|17530176|gb|AF416558.1|AF416558[17530176]
    • 1882: BC018926
      Homo sapiens, vanilloid receptor-like protein, clone MGC:12549 IMAGE:4298484, mRNA, complete cds
      gi|17511937|gb|BC018926.1|BC018926[17511937]
    • 1883: BC018778
      Homo sapiens, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1, clone MGC:32075 IMAGE:4870476, mRNA, complete cds
      gi|17511855|gb|BC018778.1|BC018778[17511855]
    • 1884: NM004625
      Homo sapiens wingless-type MMTV integration site family, member 7A (WNT7A), mRNA
      gi|17505190|ref|NM004625.2|[17505190]
    • 1885: L78805
      Homo sapiens G protein-coupled receptor gene, partial cds
      gi|17466993|gb|L78805.1|HUMGPCRE[17466993]
    • 1886: NM003602
      Homo sapiens FK506 binding protein 6 (36 kD) (FKBP6), mRNA
      gi|17149848|ref|NM003602.2|[17149848]
    • 1887: NM000801
      Homo sapiens FK506 binding protein 1A (12 kD) (FKBP1A), transcript variant 12B,
      mRNA
      gi|17149837|ref|NM000801.2|[17149837]
    • 1888: NM054014
      Homo sapiens FK506 binding protein 1A (12 kD) (FKBP1A), transcript variant 12A,
      mRNA
      gi|17149835|ref|NM054014.1|[17149835]
    • 1889: AF411044
      Homo sapiens DnaJ protein Tid-1 mRNA, complete cds
      gi|17066574|gb|AF411044.1|AF411044[17066574]
    • 1890: NM003728
      Homo sapiens unc-5 homolog B (C. elegans) (UNC5C), mRNA
      gi|16933524|ref|NM003728.2|[16933524]
    • 1891: NM005633
      Homo sapiens son of sevenless homolog 1 (Drosophila) (SOS1), mRNA
      gi|15529995|ref|NM005633.2|[15529995]
    • 1892: AJ308539
      Homo sapiens partial mRNA for T-cell receptor beta chain V-D-J region (TCRBV7BJ2S4 gene)
      gi|4787781|emb|AJ308539.1|HSA308539[14787781]
    • 1893: AJ308538
      Homo sapiens partial mRNA for T-cell receptor beta chain V-D-J region (TCRBV14BJ1S1 gene)
      gi|14787779|emb|AJ308538.1|HSA308538[14787779]
    • 1894: AJ308537
      Homo sapiens partial mRNA for T-cell receptor beta chain V-D-J region (TCRBV17BJ2S7 gene)
      gi|14787777|emb|AJ308537.1|HSA308537[14787777]
    • 1895: AJ308536
      Homo sapiens partial mRNA for T-cell receptor beta chain V-D-J region (TCRBV23BJ2S2 gene)
      gi|14787775|emb|AJ308536.1|HSA308536[14787775]
    • 1896: AJ308535
      Homo sapiens partial mRNA for T-cell receptor beta chain V-D-J region (TCRBV12BJ1S5 gene)
      gi|14787773|emb|AJ308535.1|HSA308535[14787773]
    • 1897: AJ308534
      Homo sapiens partial mRNA for T-cell receptor beta chain, V-D-J region (TCRBV1BJ2S1 gene)
      gi|14787771|emb|AJ308534.1|HSA308534[14787771]
    • 1898: AJ308533
      Homo sapiens partial mRNA for T-cell receptor beta chain, V-D-J region (TCRBV25BJ2S7 gene)
      gi|14787769|emb|AJ308533.1|HSA308533[14787769]
    • 1899: AJ308532
      Homo sapiens partial mRNA for T-cell receptor beta chain, V-D-J region (TCRBV22BJ2S7 gene)
      gi|14787767|emb|AJ308532.1|HSA308532[14787767]
    • 1900: NM014459
      Homo sapiens protocadherin 17 (PCDH17), mRNA
      gi|14589926|ref|NM014459.2|[14589926]
    • 1901: NM032961
      Homo sapiens protocadherin 10 (PCDH10), transcript variant 1, mRNA
      gi|14589915|ref|NM032961.1|[14589915]
    • 1902: NM020815
      Homo sapiens protocadherin 10 (PCDH10), transcript variant 2, mRNA
      gi|14589913|ref|NM020815.1|[14589913]
    • 1903: NM032966
      Homo sapiens Burkitt lymphoma receptor 1, GTP binding protein (BLR1), transcript
      variant 2, mRNA
      gi|145
    • 2001: AF011513
      Homo sapiens isolate MwCCR5-1553 CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305143|gb|AF011513.1|AF011513[2305143]
    • 2002: AF011512
      Homo sapiens isolate MwCCR5-107 CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305141|gb|AF011512.1|AF011512[2305141]
    • 2003: AF011511
      Homo sapiens isolate KeCCR5-3b CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305139|gb|AF011511.1|AF011511[2305139]
    • 2004: AF011510
      Homo sapiens isolate KeCCR5-3a CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305137|gb|AF011510.1|AF011510[2305137]
    • 2005: AF011509
      Homo sapiens isolate KeCCR5-116 CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305135|gb|AF011509.1|AF011509[2305135]
    • 2006: AF011508
      Homo sapiens isolate KeCCR5-111 CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305133|gb|AF011508.1|AF011508[2305133]
    • 2007: AF011507
      Homo sapiens isolate InCCR5-72a CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305131|gb|AF011507.1|AF011507[2305131]
    • 2008: AF011506
      Homo sapiens isolate InCCR5-71b CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305129|gb|AF011506.1|AF011506[2305129]
    • 2009: AF011505
      Homo sapiens isolate InCCR5-71a CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305127|gb|AF0115050.1|AF011505[2305127]
    • 2010: AF011504
      Homo sapiens isolate InCCR5-46 CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305125|gb|AF011504.1|AF011504[2305125]
    • 2011: AF011503
      Homo sapiens isolate InCCR5-467 CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305123|gb|AF011503.1|AF011503[2305123]
    • 2012: AF011502
      Homo sapiens isolate InCCR5-463 CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305121|gb|AF011502.1|AF011502[2305121]
    • 2013: AF011501
      Homo sapiens isolate InCCR5-45c CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305119|gb|AF011501.1|AF011501[2305119]
    • 2014: AF011500
      Homo sapiens isolate HtCCR5-104 CCR5 receptor (CCR5) mRNA, partial cds
      gi|2305117|gb|AF011500.1|AF011500[2305117]
    • 2015: U77732
      Homo sapiens glycine receptor alpha 1 subunit gene, partial cds
      gi|1718390|gb|U77732.1|HSU77732[1718390]
    • 2016: NM033519
      Homo sapiens olfactory receptor sdolf (sdolf), mRNA
      gi|15723373|ref|NM033519.1|[15723373]
    • 2017: NM032192
      Homo sapiens hypothetical protein FLJ20940 (FLJ20940), mRNA
      gi|14149882|ref|NM032192.1|[14149882]
    • 2018: NM032152
      Homo sapiens PRAM-1 protein (PRAM-1), mRNA
      gi|14149826|ref|NM032152.1|[14149826]
    • 2019: NM032142
      Homo sapiens hypothetical protein FLJ10352 (FLJ10352), mRNA
      gi|14149808|ref|NM032142.1|[14149808]
    • 2020: NM004801
      Homo sapiens neurexin 1 (NRXN1), mRNA
      gi|14149612|ref|NM004801.1|[14149612]
    • 2021: NM031936
      Homo sapiens G protein-coupled receptor 61 (GPR61), mRNA
      gi|13994319|ref|NM031936.1|[13994319]
    • 2022: NM030901
      Homo sapiens olfactory receptor, family 7, subfamily A, member 17 (OR7A17), mRNA
      gi|13775161|ref|NM030901.1|[13775161]
    • 2023: NM024681
      Homo sapiens hypothetical protein FLJ12242 (FLJ12242), mRNA
      gi|13489098|ref|NM024681.1|[13489098]
    • 2024: NM022571
      Homo sapiens putative leukocyte platelet-activating factor receptor (HUMNPIIY20), mRNA
      gi|12007653|ref|NM022571.1|[12007653]
    • 2025: NM022065
      Homo sapiens hypothetical protein FLJ21877 (FLJ21877), mRNA
      gi|11545774|ref|NM022065.1|[11545774]
    • 2026: NM020806
      Homo sapiens gephyrin (GPHN), mRNA
      gi|10880982|ref|NM020806.1|[10880982]
    • 2027: NM021258
      Homo sapiens interleukin 22 receptor (IL22R), mRNA
      gi|10864066|ref|NM021258.1|[10864066]
    • 2029: NM020400
      Homo sapiens G protein-coupled receptor 92 (GPR92), mRNA
      gi|9966878|ref|NM020400.1|[9966878]
    • 2030: NM000888
      Homo sapiens integrin, beta 6 (ITGB6), mRNA
      gi|9966771|ref|NM000888.31[9966771]
    • 2032: NM018113
      Homo sapiens lipocalin-interacting membrane receptor (LIMR), mRNA
      gi|8922462|ref|NM018113.1|[8922462]
    • 2033: NM018423
      Homo sapiens hypothetical protein DKFZp761P1010 (DKFZp761P1010), mRNA
      gi|8922178|ref|NM018423.1|[8922178]
    • 2034: AF257182
      Homo sapiens G-protein-coupled receptor 48 (GPR48) mRNA, complete cds
      gi|7739736|gb|AF257182.1|AF257182[7739736]
    • 2035: NM016442
      Homo sapiens type 1 tumor necrosis factor receptor shedding aminopeptidase regulator (ARTS-1), mRNA
      gi|7706544|ref|NM016442.1|[7706544]
    • 2036: NM015364
      Homo sapiens MD-2 protein (MD-2), mRNA
      gi|7702503|ref|NM015364.1|[7702503]
    • 2037: NM014380
      Homo sapiens nerve growth factor receptor (TNFRSF16) associated protein 1 (NGFRAP1), mRNA
      gi|7657043|ref|NM014380.1|[7657043]
    • 2038: NM013308
      Homo sapiens platelet activating receptor homolog (H963), mRNA
      gi|7019400|ref|NM013308.1|[7019400]
    • 2039: NM013333
      Homo sapiens EH domain-binding mitotic phosphoprotein (EPSIN), mRNA
      gi|7019368|ref|NM013333.1|[7019368]
    • 2040: NM007369
      Homo sapiens G-protein coupled receptor (RE2), mRNA
      gi|6677700|ref|NM007369.1|[6677700]
    • 2041: NM002673
      Homo sapiens plexin B1 (PLXNB1), mRNA
      gi|6631105|ref|NM002673.1|[6631105]
    • 2042: NM007115
      Homo sapiens tumor necrosis factor, alpha-induced protein 6 (TNFAIP6), mRNA
      gi|6005905|ref|NM007115.1|[6005905]
    • 2044: NM007223
      Homo sapiens putative G protein coupled receptor (GPR), mRNA
      gi|6005771|ref|NM007223.1|[6005771]
    • 2045: NM006748
      Homo sapiens Src-like-adaptor (SLA), mRNA
      gi|5803170|ref|NM006748.1|[5803170]
    • 2046: NM006681
      Homo sapiens neuromedin U (NMU), mRNA
      gi|5729946|ref|NM006681.1|[5729946]
    • 2047: NM006068
      Homo sapiens toll-like receptor 6 (TLR6), mRNA
      gi|5174720|ref|NM006068.1|[5174720]
    • 2048: NM006018
      Homo sapiens putative chemokine receptor; GTP-binding protein (HM74), mRNA
      gi|5174460|ref|NM006018.1|[5174460]
    • 2049: NM006098
      Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1), mRNA
      gi|5174446|ref|NM006098.1|[5174446]
    • 2050: NM005879
      Homo sapiens TRAF interacting protein (TRIP), mRNA
      gi|5032194|ref|NM005879.1|[5032194]
    • 2051: NM005843
      Homo sapiens signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
      (STAM2), mRNA
      gi|5032126|ref|NM005843.1|[5032126]
    • 2052: NM005505
      Homo sapiens CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1 (CD36L1), mRNA
      gi|5031628|ref|NM005505.1|[5031628]
    • 2053: NM005795
      Homo sapiens calcitonin receptor-like (CALCRL), mRNA
      gi|5031620|ref|NM005795.1|[5031620]
    • 2054: NM005400
      Homo sapiens protein kinase C, epsilon (PRKCE), mRNA
      gi|4885562|ref|NM005400.1|[4885562]
    • 2057: NM004488
      Homo sapiens glycoprotein V (platelet) (GP5), mRNA
      gi|4758459|ref|NM004488.1|[4758459]
    • 2058: NM004122
      Homo sapiens growth hormone secretagogue receptor (GHSR), mRNA
      gi|4758433|ref|NM004122.1|[4758433]
    • 2059: NM004438
      Homo sapiens EphA4 (EPHA4), mRNA
      gi|4758279|ref|NM004438.1|[4758279]
    • 2060: NM004198
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 6 (CHRNA6), mRNA
      gi|4757981|ref|NM004198.1|[4757981]
    • 2061: NM004054
      Homo sapiens complement component 3a receptor 1 (C3AR1). mRNA
      gi|4757887|ref|NM004054.1|[4757887]
    • 2062: NM003955
      Homo sapiens STAT induced STAT inhibitor 3 (SSI-3), mRNA
      gi|4507234|ref|NM003955.1|[4507234]
    • 2063: NM003693
      Homo sapiens acetyl LDL receptor; SREC=scavenger receptor expressed by endothelial cells (SREC), mRNA
      gi|4507202|ref|NM003693.1|[4507202]
    • 2064: NM003625
      Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),
      interacting protein (liprin), alpha 2 (PPFIA2), mRNA
      gi|4505984|ref|NM003625.1|[4505984]
    • 2065: NM000286
      Homo sapiens peroxisomal biogenesis factor 12 (PEX12), mRNA
      gi|4505720|ref|NM000286.1|[4505720]
    • 2066: NM002563
      Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 (P2RY1), mRNA
      gi|4505556|ref|NM002563.1|[4505556]
    • 2067: NM000913
      Homo sapiens opiate receptor-like 1 (OPRL1), mRNA
      gi|4505512|ref|NM000913.1|[4505512]
    • 2068: NM002333
      Homo sapiens low density lipoprotein receptor-related protein 3 (LRP3), mRNA
      gi|4505014|ref|NM002333.1|[4505014]
    • 2069: NM001957
      Homo sapiens endothelin receptor type A (EDNRA), mRNA
      gi|4503464|ref|NM001957.1|[4503464]
    • 2070: L34726
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100206|gb|L34726.1|HUMTCRBZ[1100206]
    • 2071: L34725
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A1, 24; B7, 8; DR 1, 3), partial cds
      gi|1100204|gb|L34725.1|HUMTCRBY[1100204]
    • 2072: L34724
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100202|gb|L34724.1|HUMTCRBU[1100202]
    • 2073: L34723
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100200|gb|L34723.1|HUMTCRBT[1100200]
    • 2074: L34722
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A1, 24; B7, 8; DR 1, 3), partial cds
      gi|1100198|gb|L34722.1|HUMTCRBS[1100198]
    • 2075: L34721
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR 2, 7). partial cds
      gi|1100196|gb|L34721.1|HUMTCRBQ[1100196]
    • 2076: L34719
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A1, 24; B7, 8; DR 1, 3), partial cds
      gi|1100192|gb|L34719.1|H1MTCRBO[1100192]
    • 2077: L34737
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR2, 7), partial cds
      gi|1100188|gb|L34737.1|HUMTCRBAO[1100188]
    • 2078: L34736
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR2, 7), partial cds
      gi|1100186|gb|L34736.1|HUMTCRBAN[1100186]
    • 2079: L34735
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A1, 24; B7, 8; DR 1, 3), partial cds
      gi|1100184|gb|L34735.1|HUMTCRBAM[1100184]
    • 2080: L34733
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1001179|gb|L34733.1|HUMTCRBAK[1100179]
    • 2081: L34732
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29: B7, 44; DR 2, 7), partial cds
      gi|1100177|gb|L34732.1|HUMTCRBAJ[1100177]
    • 2082: L34731
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100175|gb|L34731.1|HUMTCRBAI[1100175]
    • 2083: L34730
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A1, 24; B7, 8; DR 1, 3), partial cds
      gi|1100173|gb|L34730.1|HUMTCRBAH[1100173]
    • 2084: L34728
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100169|gb|L34728.1|HUMTCRBAF[1100169]
    • 2085: L34727
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100167|gb|L34727.1|HUMTCRBAE[1100167]
    • 2086: L34703
      Homo sapiens T-cell receptor alpha chain (TCRA) mRNA (HLA-A1, 24; B7, 8; DR 1,
      3), complete cds
      gi|110065|gb|L34703.1|HUMTCRAZ[1100165]
    • 2087: L34702
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100163|gb|L34702.1|HUMTCRAY[1100163]
    • 2088: L34701
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100161|gb|L34701.1|HUMTCRAV[1100161]
    • 2089: L34700
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1001159|gb|L34700.1|HUMTCRAU[1100159]
    • 2090: L34699
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A1, 24; B7, 8; C7; DR 1, 3),
      partial cds
      gi|1001157|gb|L34699.1|HUMTCRAT[1100157]
    • 2091: L34698
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), complete cds
      gi|1100155|gb|L34698.1|HUMTCRAQ[1100155]
    • 2092: L34695
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR2, 7), partial cds
      gi|1001153|gb|L34695.1|HUMTCRAP[1100153]
    • 2093: L34694
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A1, 24; B7, 8; C7; DR 1, 3),
      partial cds
      gi|1100151|gb|L34694.1|HUMTCRAO[1100151]
    • 2094: L34738
      Homo sapiens T-cell receptor beta (TCRB) mRNA (HLA-A1, 24; B7, 8; C7; DR 1, 3),
      partial cds
      gi|1100149|gb|L34738.1|HUMTCRAAX[1100149]
    • 2095: L34718
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100147|gb|L34718.1|HUMTCRAAW[1100147]
    • 2096: L34717
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|100145|gb|L34717.1|HUMTCRAAV[1100145]
    • 2097: L34716
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A1, 24; B7, 8; DR 1, 3), partial cds
      gi|100143|gb|L34716.1|HUMTCRAAU[1100143]
    • 2098: L34715
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A1, 24; B7, 8; DR 1, 3), partial cds
      gi|1100141|gb|L34715.1|HUMTCRAAT[1100141]
    • 2099: L34714
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A1, 24; B7, 8; DR 1, 3), partial cds
      gi|1100139|gb|L34714.1|HUMTCRAAT[1100139]
    • 2100: L34713
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100137|gb|L34713.1|HUMTCRAAR[1100137]
    • 2101: L34712
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100135|gb|L34712.1|HUMTCRAAQ[1100135]
    • 2102: L34711
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100133|gb|L34711.1|HUMTCRAAP[1100133]
    • 2103: L34710
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100131|gb|L34710.1|HUMTCRAAO[1100131]
    • 2104: L34709
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100129|gb|L34709.1|HUMTCRAAN[1100129]
    • 2105: L34708
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A1, 24; B7, 8; DR1, 3), partial cds
      gi|1100127|gb|L34708.1|HUMTCRAAM[1100127]
    • 2106: L34707
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100125|gb|L34707.1|HUMTCRAAL[1100125]
    • 2107: L34706
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100123|gb|L34706.1HUMTCRAAK[1100123]
    • 2108: L34705
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100121|gb|L34705.1|HUMTCRAAJ[1100121]
    • 2109: L34704
      Homo sapiens T-cell receptor alpha (TCRA) mRNA (HLA-A3, 29; B7, 44; DR 2, 7), partial cds
      gi|1100119|gb|L34704.1|HUMTCRAAI[1100119]
    • 2110: L29037
      Human T-cell antigen receptor mRNA
      gi|517066|gb|L29037.1|HUMTCRBW[517066]
    • 2111: L29038
      Human T-cell antigen receptor mRNA
      gi|456432|gb|L29038.1|HUMTCRBX[456432]
    • 2112: L29036
      Human T-cell antigen receptor mRNA
      gi|456431|gb|L29036.1|HUMTCRAX[456431]
    • 2113: L29035
      Human T-cell antigen receptor mRNA
      gi|456430|gb|L29035.1|HUMTCRAW[456430]
    • 2114: AF106913
      Homo sapiens CRL3 protein (CRL3) mRNA, complete cds
      gi|7221662|gb|AF106913.1|AF106913[17221662]
    • 2115: AB055881
      Homo sapiens NKp30 mRNA for natural killer cell receptor, complete cds
      gi|17221621|dbj|AB055881.1|AB055881[17221621]
    • 2116: AJ417149
      Homo sapiens partial mRNA for T cell receptor beta chain (TCRB gene), clone 21
      gi|17154680|emb|AJ417149.1|HSA417149[17154680]
    • 2117: AJ417148
      Homo sapiens partial mRNA for T cell receptor beta chain (TCRB gene), clone 17
      gi|17148484|emb|AJ417148.1|HSA417148[17148484]
    • 2118: NM054021
      Homo sapiens G protein-coupled receptor 101 (GPR101), mRNA
      gi|16876434|ref|NM054021.1|[16876434]
    • 2119: NM052939
      Homo sapiens Fc receptor-like protein 3 (FCRH3), mRNA
      gi|16418420|ref|NM052939.1|[16418420]
    • 2120: NM052938
      Homo sapiens Fc receptor-like protein 1 (FCRH1), mRNA
      gi|16418418|ref|NM052938.1|[16418418]
    • 2121: NM003823
      Homo sapiens tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), transcript variant M68E, mRNA
      gi|14790166|ref|NM003823.2|[14790166]
    • 2122: NM006470
      Homo sapiens tripartite motif-containing 16 (TRIM16), mRNA
      gi|14577927|ref|NM006470.2|[14577927]
    • 2123: NM031918
      Homo sapiens Kruppel-like factor 16 (KLF16), mRNA
      gi|13994286|ref|NM031918.1|[13994286]
    • 2124: NM023945
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 5 (MS4A5), mRNA
      gi|12965204|ref|NM023945.1|[12965204]
    • 2125: NM018485
      Homo sapiens G protein-coupled receptor C5L2 (LOC55868), mRNA
      gi|8923872|ref|NM018485.1|[8923872]
    • 2126: NM016562
      Homo sapiens toll-like receptor 7 (TLR7), mRNA
      gi|7706092|ref|NM016562.1|[7706092]
    • 2130: NM006138
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) (MS4A3), mRNA
      gi|5453608|ref|NM006138.1|[5453608]
    • 2131: AF447176
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exon 20 and complete cds
      gi|17432420|gb|AF447176.1|F447157S11[17432420]
    • 2132: AF447175
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exon 19
      gi|17432419|gb|AF447175.1|F447157S10[17432419]
    • 2133: AF447174
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exon 18
      gi|17432418|gb|AF447174.1|F447157S09[17432418]
    • 2134: AF447173
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exon 17
      gi|17432417|gb|AF447173.1|F447157S08[17432417]
    • 2135: AF447171
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exons 15 and 16
      gi|17432416|gb|AF447171.1|F447157S07[17432416]
    • 2136: AF447170
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exon 14
      gi|174324155gb|AF447170.1|F447157S06[17432415]
    • 2137: AF447167
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exons 11, 12, and 13
      gi|17432414|gb|AF447167.1|F447157S05[17432414]
    • 2138: AF447164
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exons 8, 9, and 10
      gi|17432413|gb|AF447164.1|F447157S04[17432413]
    • 2139: AF447162
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exons 6 and 7
      gi|17432412|gb|AF447162.1|F447157S03[17432412]
    • 2140: AF447158
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exons 2, 3, 4, and 5
      gi|17432411|gb|AF447158.1F447157S02[17432411]
    • 2141: AF447157
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, exon 1
      gi|17432410|gb|AF447157.1|F447157S01[17432410]
    • 2142: AH011239
      Homo sapiens protein tyrosine kinase-7 (PTK7) gene, complete cds
      gi|17432409|gb|AH011239.1|SEG_F447157S[17432409]
    • 2143: AF374231
      Homo sapiens corticotropin releasing hormone receptor variant 1 h mRNA, partial
      cds, alternatively spliced
      gi|17432316|gb|AF374231.1|AF374231[17432316]
    • 2145: AY013309
      Homo sapiens clone FM1-3.3.12A immunoglobulin heavy chain variable region gene,
      partial cdc
      gi|17220530|gb|AY013309.1|[17220530]
    • 2146: AY013308
      Homo sapiens clone FL1-2.4.2G immunoglobulin heavy chain variable region gene,
      partial cds
      gi|17220528|gb|AY013308.1|[17220528]
    • 2147: AY013307
      Homo sapiens clone FL1-2.4.12A immunoglobulin heavy chain variable region gene,
      partial cds
      gi|17220526|gb|AY013307.1|[17220526]
    • 2148: AY013306
      Homo sapiens clone FL3-3.4.4G immunoglobulin heavy chain variable region gene,
      partial cds
      gi|17220524|gb|AY013306.1|[17220524]
    • 2149: AB062787
      Homo sapiens mRNA for triggering receptor TREM-2V, complete cds
      gi|17425161|dbj|AB062787.1|AB062787[17425161]
    • 2150: NM003392
      Homo sapiens wingless-type MMTV integration site family, member 5A (WNT5A), mRNA
      gi|17402917|ref|NM003392.2|[17402917]
    • 2152: AJ421518
      Homo sapiens mRNA for tumor necrosis factor-stimulated gene 6 (TSG-6) protein,
      G431 allele
      gi|17402491|emb|A1|AJ421518.1|HSA421518[17402491]
    • 2153: NM053049
      Homo sapiens stresscopin (SPC), mRNA
      gi|16596691|ref|NM053049.1|[16596691]
    • 2154: AF430697
      Homo sapiens T cell receptor beta variable region, Vbeta 13S3-KRGAYETQYF-Jbeta
      2.5 mRNA, partial cds
      gi|16566919|gb|AF430697.1|AF430697[16566919]
    • 2155: AF430696
      Homo sapiens T cell receptor beta variable region, Vbeta 13S2A1T-SEVRETQYF-Jbeta
      2.5 mRNA, partial cds
      gi|16566916|gb|AF430696.1|AF430696[16566916]
    • 2156: AF430695
      Homo sapiens T cell receptor beta variable region, Vbeta 13S3-EKVTGGETQYF-Jbeta
      2.5 mRNA, partial cds
      gi|16566913|gb|AF430695.1|AF430695[16566913]
    • 2157: AF430694
      Homo sapiens T cell receptor beta variable region, Vbeta
      13S2A1T-QGRTSVIETQYF-Jbeta 2.5 mRNA, partial cds
      gi|16566910|gb|AF430694.1|AF430694[16566910]
    • 2158: AF430693
      Homo sapiens T cell receptor beta variable region, Vbeta
      13S2A1T-RSDRRKTRYF-Jbeta2.5 mRNA, partial cds
      gi|16566907|gb|AF430693.1|AF430693[16566907]
    • 2159: AF430692
      Homo sapiens T cell receptor beta variable region, Vbeta 13S3-GRGAQETQYF-Jbeta
      2.5 mRNA, partial cds
      gi|16566904|gb|AF430692.1|AF430692[16566904]
    • 2160: AF430691
      Homo sapiens T cell receptor beta variable region, Vbeta 13S2A1T-GGQTYF-Jbeta 2.5 mRNA, partial cds
      gi|1656690|gb|AF430691.1|AF430691[16566901]
    • 2161: AF430690
      Homo sapiens T cell receptor beta variable region, Vbeta 1S1A1N1-SGLTPNTGELFF-Jbeta 2.2 mRNA, partial cds
      gi|16566898|gb|AF430690.1|AF430690[16566898]
    • 2162: AF430689
      Homo sapiens T cell receptor beta variable region, Vbeta 13S6A1N1-TSPVPIGTDTQYF-Jbeta 2.3 mRNA, partial cds
      gi|16566895|gb|AF430689.1|AF430689[16566895]
    • 2163: AF430688
      Homo sapiens T cell receptor beta variable region, Vbeta 13S3-MFGGSTGELFF-Jbeta
      2.2 mRNA, partial cds
      gi|16566892|gb|AF430688.1|AF430688[16566892]
    • 2164: AF430687
      Homo sapiens T cell receptor beta variable region, Vbeta 13S3-AQGKGTQYF-Jbeta 2.5 mRNA, partial cds
      gi|16566889|gb|AF430687.1|AF430687[16566889]
    • 2165: AF430686
      Homo sapiens T cell receptor beta variable region, Vbeta 13 S3-EQGLLSTDTQYF-Jbeta 2.3 mRNA, partial cds
      gi|16566886|gb|AF430686.1|AF430686[16566886]
    • 2166: AF430685
      Homo sapiens T cell receptor beta variable region, Vbeta 13S5-ETPGQGAGELFF-Jbeta
      2.2 mRNA, partial cds
      gi|16566883|gb|AF430685.1|AF430685[16566883]
    • 2167: AF430684
      Homo sapiens T cell receptor beta variable region, Vbeta 13S5-RLAGASYNEQYF-Jbeta
      2.1 mRNA, partial cds
      gi|16566880|gb|AF430684.1|AF430684[16566880]
    • 2168: AF430683
      Homo sapiens T cell receptor beta variable region, Vbeta 13S5-DTAGSTDTQYF-Jbeta
      2.3 mRNA, partial cds
      gi|16566877|gb|AF430683.1|AF430683[16566877]
    • 2169: AF430682
      Homo sapiens T cell receptor beta variable region, Vbeta 13S5-EVASGTDTQYF-Jbeta
      2.3 mRNA, partial cds
      gi|16566874|gb|AF430682.1|AF430682[16566874]
    • 2170: AF430681
      Homo sapiens T cell receptor beta variable region, Vbeta S6A3N2T-ASSGGYEQYF-Jbeta 2.7 mRNA, partial cds
      gi|16566871|gb|AF430681.1|AF430681[16566871]
    • 2171: AF430680
      Homo sapiens T cell receptor beta variable region, Vbeta 5 S3A1T/S1A1T-RRSDTQYF-Jbeta 2.3 mRNA, partial cds
      gi|16566868|gb|AF430680.1|AF430680[16566868]
    • 2172: AF430679
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-FGGEDTDTQYF-Jbeta 2.3 mRNA, partial cds
      gi|16566865|gb|AF430679.1|AF430679[16566865]
    • 2173: AF430678
      Homo sapiens T cell receptor beta variable region, Vbeta 5 S2-FGTRGNEQFF-Jbeta
      2.7 mRNA, partial cds
      gi|16566862|gb|AF430678.1|AF430678[16566862]
    • 2174: AF430677
      Homo sapiens T cell receptor beta variable region, Vbeta 5-FQGARETQYF-Jbeta 2.5
      mRNA, partial cds
      gi|16566859|gb|AF430677.1|AF430677[16566859]
    • 2175: AF430676
      Homo sapiens T cell receptor beta variable region, Vbeta 5S6A3N2T-FTGTGIYGYTF-Jbeta 1.2 mRNA, partial cds
      gi|16566856|gb|AF430676.1|AF430676[16566856]
    • 2176: AF430675
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-APLTGDSGNTIYF-Jbeta 1.3 mRNA, partial cds
      gi|16566853|gb|AF430675.1|AF430675[16566853]
    • 2177: AF430674
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1TSDLSGANVLTF-Jbeta
      2.6 mRNA, partial cds
      gi|16566850|gb|AF430674.1|AF430674[16566850]
    • 2178: AF430673
      Homo sapiens T cell receptor beta variable region, Vbeta 5S6A3N2T-GQGKGTF-Jbeta
      1.2 mRNA, partial cds
      gi|16566847|gb|AF430673.1|AF430673[16566847]
    • 2179: AF430672
      Homo sapiens T cell receptor beta variable region, Vbeta 5S6A3N2T-YTGGVWRNQYF-Jbeta 2.5 mRNA, partial cds
      gi|16566844|gb|AF430672.1|AF430672[16566844]
    • 2180: AF430671
      Homo sapiens T cell receptor beta variable region, Vbeta 5S2-FSGGAHTQYF-Jbeta 2.3 mRNA, partial cds
      gi|16566841|gb|AF430671.1|AF430671[16566841]
    • 2181: AF430670
      Homo sapiens T cell receptor beta variable region, Vbeta 5S2/S6A3N2T-SGQGKTEAFF-Jbeta 1.1 mRNA, partial cds
      gi|16566838|gb|AF430670.1|AF430670[16566838]
    • 2182: AF430669
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-FSKGVTEAFF-Jbeta
      1.1 mRNA, partial cds
      gi|16566835|gb|AF430669.1|AF430669[16566835]
    • 2183: AF430668
      Homo sapiens T cell receptor beta variable region, Vbeta 5S2-SSPTGRSGNTIYF-Jbeta
      1.3 mRNA, partial cds
      gi|16566832|gb|AF430668.1|AF430668[16566832]
    • 2184: AF430667
      Homo sapiens T cell receptor beta variable region, Vbeta 5S4A2T-PLLGQGRDEQFF-Jbeta 2.1 mRNA, partial cds
      gi|16566829|gb|AF430667.1|AF430667[16566829]
    • 2185: AF430666
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-FDFPGELFF-Jbeta
      2.2 mRNA, partial cds
      gi|16566827|gb|AF430666.1|AF430666[16566827]
    • 2186: AF430665
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-DPSGGYNEQFF-Jbeta 2.1 mRNA, partial cds
      gi|16566824|gb|AF430665.1|AF430665[16566824]
    • 2187: AF430664
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-DATGNLNEQYF-Jbeta 2.7 mRNA, partial cds
      gi|16566821|gb|AF430664.1|AF430664[16566821]
    • 2188: AF430663
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-SGQVTGELFF-Jbeta
      2.2 mRNA, partial cds
      gi|16566818|gb|AF430663.1|AF430663[16566818]
    • 2189: AF430662
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-AWWGAGYEGYF-Jbeta 2.7 mRNA, partial cds
      gi|16566815|gb|AF430662.1|AF430662[16566815]
    • 2190: AF430661
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-RRLAGVYNEQFF-Jbeta 2.1 mRNA, partial cds
      gi|16566812|gb|AF430661.1|AF430661[16566812]
    • 2191: AF430660
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-EFQAPYGYTF-Jbeta 1.2 mRNA, partial cds
      gi|6566809|gb|AF430660.1|AF430660[16566809]
    • 2192: AF430659
      Homo sapiens T cell receptor beta variable region, Vbeta 5S6A3N2T-TGTESPDTQYF-Jbeta 2.3 mRNA, partial cds
      gi|16566806|gb|AF430659.1|AF430659[16566806]
    • 2193: AF430658
      Homo sapiens T cell receptor beta variable region, Vbeta 5S6A3N2T-TFGTPTYNEQFF-Jbeta 2.1 mRNA, partial cds
      gi|16566803|gb|AF430658.1|AF430658[16566803]
    • 2194: AF430657
      Homo sapiens T cell receptor beta variable region, Vbeta 5-SGPSTDTQYF-Jbeta 2.3
      mRNA, partial cds
      gi|16566800|gb|AP430657.1|AF430657[16566800]
    • 2195: AF430656
      Homo sapiens T cell receptor beta variable region, Vbeta 5S2-NPGGNYGYTF-Jbeta 1.2 mRNA, partial cds
      gi|16566797|gb|AF430656.1|AF430656[16566797]
    • 2196: AF430655
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-VIGTYEQYF-Jbeta
      2.7 mRNA, partial cds
      gi|6566794|gb|AF430655.1|AF430655[16566794]
    • 2197: AF430654
      Homo sapiens T cell receptor beta variable region, Vbeta 5S2-AGGETQYF-J beta
      2.5
      mRNA, partial cds
      gi|16566791|gb|AF430654.1|AF430654[16566791]
    • 2198: AF430653
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-VSGRGSYEQYF-Jbeta 2.7 mRNA, partial cds
      gi|16566788|gb|AF430653.1|AF430653[16566788]
    • 2199: AF430652
      Homo sapiens T cell receptor beta variable region, Vbeta 5S2-VRSEAFF-JBeta 1.1
      mRNA, partial cds
      gi|16566785|gb|AF430652.1|AF430653[16566785]
    • 2200: AF430651
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-RTRTGETNTGELFF-JBeta2.2 mRNA, partial cds
      gi|16566782|gb|AF430651.1|AF430651[16566782]
    • 2201: AF430650
      Homo sapiens T cell receptor beta variable region, Vbeta 5S6A3N2T-GAGPSGELFF-JBeta 2.2 mRNA, partial cds
      gi|16566779|gb|AF430650.1|AF430650[16566779]
    • 2202: AF430649
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1A1T-GGGTGELFF-Jbeta2.2 mRNA, partial cds
      gi|16566776(gb|AF430649.1|AF430649[16566776]
    • 2203: AF430648
      Homo sapiens T cell receptor beta variable region, Vbeta 5S1AT-PGQGAYEQYF-2.7 mRNA, partial cds
      gi|16566773|gb|AF430648.1|AF430648[16566773]
    • 2204: AF430647
      Homo sapiens T cell receptor beta variable region, Vbeta 5S2-RPDSGYTF-Jeta1.2 mRNA, partial cds
      gi|6566770|gb|AF430647.1|AF430647[16566770]
    • 2205: AF411117
      Homo sapiens G protein-coupled receptor (GPR103) mRNA, complete cds
      gi|16566346|gb|AF411117.1|AF411117[16566346]
    • 2206: AF411116
      Homo sapiens G protein-coupled receptor (GPR102) gene, complete cds
      gi|16566343|gb|AF411116.1|AF411116[16566343]
    • 2207: AF411115
      Homo sapiens G protein-coupled receptor (GPR101) gene, complete cds
      gi|16566340|gb|AF411115.1|AF411115[16566340]
    • 2208: AF411114
      Homo sapiens G protein-coupled receptor (GPR95) mRNA, complete cds
      gi|16566337|gb|AF411114.1|AF411114[16566337]
    • 2209: AF411113
      Homo sapiens G protein-coupled receptor (GPR94) gene, complete cds
      gi|16566334|gb|AF411113.1|AF411113[16566334]
    • 2210: AF411112
      Homo sapiens G protein-coupled receptor (GPR93) gene, complete cds
      gi|16566331|gb|AF411112.1|AF411112[16566331]
    • 2211: AF411111
      Homo sapiens G protein-coupled receptor (GPR82) gene, complete cds
      gi|16566328|gb|AF411111.1|AF411111[16566328]
    • 2212: AF411110
      Homo sapiens G protein-coupled receptor (GPR81) gene, complete cds
      gi|16566325|gb|AF411110.1|AF411110[16566325]
    • 2213: AF411109
      Homo sapiens G protein-coupled receptor (GPR80) gene, complete cds
      gi|16566322|gb|AF411109.1|AF411109[16566322]
    • 2215: AF411107
      Homo sapiens G protein-coupled receptor (GPR78) mRNA, complete cds
      gi|1656631B|gb|AF411107.1|AF411107[16566318]
    • 2216: AF406692
      Homo sapiens G protein-coupled receptor GPR86 mRNA, complete cds
      gi|5487985|gb|AF406692.1|AF406692[15487985]
    • 2217: NM019035
      Homo sapiens protocadherin 18 (PCDH18), mRNA
      gi|14589928|ref|NM019035.1|[14589928]
    • 2218: AF214012
      Homo sapiens prolactin receptor gene, exon 11 and partial sequence
      gi|14328908|gb|AF214012.1|AF214012[14328908]
    • 2219: NM030943
      Homo sapiens amnionless protein (AMN), mRNA
      gi|13569914|ref|NM030943.1|[13569914]
    • 2220: NM023922
      Homo sapiens taste receptor, type 2, member 14 (TAS2R14), mRNA
      gi|12965181|ref|NM023922.1|[12965181]
    • 2221: NM023921
      Homo sapiens taste receptor, type 2, member 10 (TAS2R10), mRNA
      gi|12965179|ref|NM023921.1|[12965179]
    • 2222: NM023920
      Homo sapiens taste receptor, type 2, member 13 (TAS2R13), mRNA
      gi|12965177|ref|NM023920.1|[12965177]
    • 2223: NM023919
      Homo sapiens taste receptor, type 2, member 7 (TAS2R7), mRNA
      gi|12965175|ref|NM023919.1|[12965175]
    • 2224: NM023918
      Homo sapiens taste receptor, type 2, member 8 (TAS2R8), mRNA
      gi|12965173|ref|NM023918.1|[12965173]
    • 2225: NM023917
      Homo sapiens taste receptor, type 2, member 9 (TAS2R9), mRNA
      gi|12965171|ref|NM023917.1|[12965171]
    • 2226: AF206696
      Homo sapiens interleukin-1 epsilon (IL1E) mRNA, complete cds
      gi|11493847|gb|AF206696.1|AF206696[11493847]
    • 2227: AF230377
      Homo sapiens interleukin-1 delta mRNA, complete cds
      gi|9651788|gb|AF230377.1|AF230377[9651788]
    • 2228: BC018284
      Homo sapiens, triggering receptor expressed on myeloid cells 2, clone IMAGE:4151400, mRNA
      gi|17390669|gb|BC018284.1|BC018284[17390669]
    • 2229: BC018130
      Homo sapiens, coagulation factor II (thrombin) receptor-like 1, clone MGC:9298
      IMAGE:3895653, mRNA, complete cds
      gi|17390291|gb|BC018130.1|BC018130[17390291]
    • 2230: BC017898
      Homo sapiens, Purinergic receptor P2Y, G protein-coupled, 12, clone MGC:23802 IMAGE:4251263, mRNA, complete cds
      gi|17389766|gb|BC017898.1|BC017898[17389766]
    • 2231: BC017865
      Homo sapiens, Fc fragment of IgG, low affinity 111a, receptor for (CD16), clone
      MGC:22630 IMAGE:4690249, mRNA, complete cds
      gi|17389687|gb|BC017865.1|BC017865[17389687]
    • 2232: BC017852
      Homo sapiens, tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain, clone IMAGE:4700855, mRNA
      gi|17389657|gb|BC017852.1|BC017852[17389657]
    • 2233: BC017784
      Homo sapiens, killer cell lectin-like receptor subfamily C, member 4, clone MGC:22279 IMAGE:4619154, mRNA, complete cds
      gi|17389488|gb|BC017784.1|BC017784[17389488]
    • 2234: BC017773
      Homo sapiens, triggering receptor expressed on myeloid cells 1, clone MGC:22242
      IMAGE:4692680, mRNA, complete cds
      gi|17389458|gb|BC017773.1|BC017773[17389458]
    • 2235: BC017730
      Homo sapiens, tumor necrosis factor receptor superfamily, member 21, clone MGC:21476 IMAGE:3847246, mRNA, complete cds
      gi|17389378|gb|BC017730.1|BC017730[17389378]
    • 2237: AJ252246
      Homo sapiens mRNA for kainate receptor subunit (GRIK2 gene)
      gi|17384623|emb|AJ252246.1|HSA252246[17384623]
    • 2238: AJ249210
      Homo sapiens mRNA for glutamate/kainate receptor subtype GluR7 (GRIK3 gene)
      gi|17384612|emb|AJ249210.1|HSA249210[17384612]
    • 2239: AJ249209
      Homo sapiens mRNA for glutamate/kainate receptor subunit KA2a (GRIK5 gene)
      gi|17384610|emb|AJ249209.1|HSA249209[17384610]
    • 2240: AJ249208
      Homo sapiens mRNA for glutamate receptor subunit GluR5 (GRIK1 gene)
      gi|17384608|emb|AJ249208.1|HSA249208[17384608]
    • 2241: AJ415410
      Homo sapiens partial IGVK1-O14 gene for immunoglobulin kappa chain variable region, donor MF, cell24
      gi|17384019|emb|AJ415410.2|HSA415410[17384019]
    • 2242: AJ415291
      Homo sapiens partial IGVH3-33 gene for immunoglobulin heavy chain variable region, donor TG, cell46
      gi|17384018|emb|AJ415291.2|HSA415291[17384018]
    • 2243: AJ414840
      Homo sapiens partial IGVKA30 gene for immunoglobulin kappa chain variable region, donor MF, cell2
      gi|17384017|emb|AJ414840.2|HSA414840[17384017]
    • 2244: NM000623
      Homo sapiens bradykinin receptor B2 (BDKRB2), mRNA
      gi|17352499|ref|NM000623.2|[17352499]
    • 2246: AJ347709
      Homo sapiens mRNA for FKBP-associated protein
      gi|15620770|emb|AJ347709.1|HSA347709[15620770]
    • 2247: AF356518
      Homo sapiens junctional adhesion molecule 3 precursor, mRNA, complete cds
      gi|13448824|gb|AF356518.1|AF356518[13448824]
    • 2248: NM021201
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 7 (MS4A7), mRNA
      gi|11139298|ref|NM021201.1|[11139298]
    • 2249: NM015344
      Homo sapiens leptin receptor overlapping transcript-like 1 (LEPROTL1), mRNA
      gi|7662509|ref|NM015344.1|[7662509]
    • 2250: AF411850
      Homo sapiens C-type lectin-like receptor CLEC-6 mRNA, complete cds
      gi|17226267|gb|AF411850.1|AF411850[17226267]
    • 2251: AF325460
      Homo sapiens dendritic lectin b isoform (CLECSF11) mRNA, complete cds, alternatively spliced
      gi|17225338|gb|AF325460.1|AF325460[17225338]
    • 2252: AF325459
      Homo sapiens dendritic lectin (CLECSF11) mRNA, complete cds, alternatively spliced
      gi|17225336|gb|AF325459.1|AF325459[17225336]
    • 2253: AF293357
      Homo sapiens AT2 receptor-interacting protein 1 mRNA, complete cds
      gi|17224595|gb|AF293357.1|AF293357[17224595]
    • 2254: AF283988
      Homo sapiens leukocyte immunoglobulin-like receptor-5 (LILRB5) mRNA, LILRB5-v1
      allele, complete cds
      gi|17224473|gb|AF283988.1|AF283988[17224473]
    • 2255: AF283987
      Homo sapiens leukocyte immunoglobulin-like receptor-2 (LILRB2) mRNA, LILRB2-v2
      allele, complete cds
      gi|17224471|gb|AF283987.1|AF283987[17224471]
    • 2256: AF283986
      Homo sapiens leukocyte immunoglobulin-like receptor-2 (LILRB2) mRNA, LILRB2-v1
      allele, complete cds
      gi|17224469|gb|AF283986.1|AF283986[17224469]
    • 2257: AF283985
      Homo sapiens leukocyte immunoglobulin-like receptor-1 (LILRB1) mRNA, LILRB1-v2
      allele, complete cds
      gi|17224467|gb|AF283985.1|AF283985[17224467]
    • 2258: AF283984
      Homo sapiens leukocyte immunoglobulin-like receptor-1 (LILRB1) mRNA, LILRB1-v1
      allele, complete cds
      gi|17224465|gb|AF283984.1|AF283984[17224465]
    • 2259: NM057170
      Homo sapiens G protein-coupled receptor kinase-interactor 2 (GIT2), transcript
      variant 2, mRNA
      gi|17149831|ref|NM057170.1|[17149831]
    • 2260: NM057169
      Homo sapiens G protein-coupled receptor kinase-interactor 2 (GIT2), transcript
      variant 1, mRNA
      gi|17149829|ref|NM057169.1|[17149829]
    • 2261: AJ417151
      Homo sapiens partial mRNA for T cell receptor beta chain (TCRB gene), clone 25
      gi|17148488|emb|AJ417151.1|HSA417151[17148488]
    • 2262: AJ417150
      Homo sapiens partial mRNA for T cell receptor beta chain (TCRB gene), clone 27
      gi|17148486|emb|AJ417150.1|HSA417150[17148486]
    • 2263: NM014776
      Homo sapiens G protein-coupled receptor kinase-interactor 2 (GIT2), transcript
      variant 3, mRNA
      gi|7661943|ref|NM014776.1|[7661943]
    • 2264: AJ239326
      Homo sapiens chromosome 21 clone cosmid LLNLc116 32E2 map 21q22.3, *** SEQUENCING IN PROGRESS ***, 4 ordered pieces
      gi|6982097|emb|AJ239326.3|HSS171M[6982097]
    • 2265: NM000675
      Homo sapiens adenosine A2a receptor (ADORA2A), mRNA
      gi|17136146|ref|NM000675.3|[17136146]
    • 2266: AF035374
      Homo sapiens Cys-rich protein (RAMP) mRNA, complete cds
      gi|2665702|gb|AF035374.1|AF035374[2665702]
    • 2267: AF282269
      Homo sapiens G protein-coupled receptor kinase 7 mRNA, complete cds
      gi|17026317|gb|AF282269.1|AF282269[17026317]
    • 2268: AF437510
      Homo sapiens T-cell receptor beta-chain mRNA, partial cds
      gi|16974744|gb|AF437510.1|AF437510[16974744]
    • 2269: AX286800
      Sequence 35 from Patent WO0178796
      gi|17048833|emb|AX286800.1|AX286800[17048833]
    • 2270: AX286799
      Sequence 34 from Patent WO0178796
      gi|17048832|emb|AX286799.1|AX286799[17048832]
    • 2271: AB005145
      Homo sapiens CL-P1 mRNA for collectin placenta 1, complete cds
      gi|17026100|dbj|AB005145.1|AB005145[17026100]
    • 2272: SEG_HUMIL3RA
      Homo sapiens gene for interleukin 3 receptor alpha subunit
      gi|1345401|dbj||SEG_HUMIL3RA[1345401]
    • 2273: L34720
      Homo sapiens T-cell receptor beta (TCRB) mRNA, partial cds
      gi|1100194|gb|L34720.1|HUMTCRBP[1100194]
    • 2274: L34734
      Homo sapiens T-cell receptor beta (TCRB) mRNA, complete cds
      gi|1100181|gb|L34734.1|HUMTCRBAL[1100181]
    • 2275: L34729
      Homo sapiens T-cell receptor beta (TCRB) mRNA, partial cds
      gi|110017|gb|L34729.1|HUMTCRBAG[1100171]
    • 2276: D49412
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 11
      gi|684969|dbj|D49412.1|HUMIL3RA11[684969]
    • 2277: D49410
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 12 and partial
      cds
      gi|684968|dbj|D49410.1|HUMIL3RA12[684968]
    • 2278: D49408
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 10
      gi|684967|dbj|D49408.1|HUMIL3RA10[684967]
    • 2279: D49409
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 6
      gi|684966|dbj|D549409.1|HUMIL3RA06[684966]
    • 2280: D49407
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 4
      gi|684965|dbj|D549407.1|HUMIL3RA04[684965]
    • 2281: D49406
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 2
      gi|684964|dbj|D549406.1|HUMIL3RA02[684964]
    • 2282: D49404
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 7
      gi|684963|dbj|D549404.1|HUMIL3RA07[684963]
    • 2283: D49403
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 5
      gi|684962|dbj|D549403.1|HUMIL3RA05[684962]
    • 2284: D49402
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 3
      gi|684961|dbj|D549402.1|HUMIL3RA03[684961]
    • 2285: D49401
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 1
      gi|684960|dbj|D549401.1|HUMIL3RA01[684960]
    • 2286: D49411
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 9
      gi|684959|dbj|D549411.1|HUMIL3RA09[684959]
    • 2287: D49405
      Homo sapiens gene for interleukin 3 receptor alpha subunit, exon 8
      gi|684958|dbj|D49405.1|HUMIL3RA08[684958]
    • 2288: SEG_HUMGRAS
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit
      gi|522101|dbj||SEG_HUMGRAS[522101]
    • 2289: D26625
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 10
      gi|467508|dbj|D526625.1|HUMGRAS10[467508]
    • 2290: D26624
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 9
      gi|467507|dbj|D526624.1|HUMGRAS09[467507]
    • 2291: D26623
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 8
      gi|467506|dbj|D526623.1|HUMGRAS08[467506]
    • 2292: D26622
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 7
      gi|467505|dbj|D526622.1|HUMGRAS07[467505]
    • 2293: D26621
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 6
      gi|467504|dbj|D526621.1|HUMGRAS06[467504]
    • 2294: D26628
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 13 and partial cds
      gi|456594|dbj|D526628.1|HUMGRAS13[456594]
    • 2295: D26627
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 12
      gi|456593|dbj|D526627.1|HUMGRAS12[456593]
    • 2296: D26626
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 11
      gi|456592|dbj|D526626.1|HUMGRAS11[456592]
    • 2297: D26620
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 5
      gi|456591|dbj|D526620.1|HUMGRAS05[456591]
    • 2298: D26619
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 4
      gi|456590|dbj|D526619.1|HUMGRAS04[456590]
    • 2299: D26618
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 3
      gi|456589|dbj|D526618.1|HUMGRAS03[456589]
    • 2300: D26617
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 2
      gi|456588|dbj|D526617.1|HUMGRAS02[456588]
    • 2301: D26616
      Homo sapiens gene for granulocyte-macrophage colony stimulating factor (GM-CSF)
      receptor alpha subunit, exon 1
      gi|456587|dbj|D526616.1|HUMGRAS01[456587]
    • 2307; AF324499
      Homo sapiens olfactory-like receptor mRNA, complete cds
      gi|17016397|gb|AF324499.1|AF324499[17016397]
    • 2308: AF308814
      Homo sapiens olfactory receptor-like protein (JCG10) mRNA, partial cds
      gi|17016395|gb|AF308814.1|AF308814[17016395]
    • 2309: AF238488
      Homo sapiens olfactory-like receptor JCG8 (JCG8) mRNA, complete cds
      gi|17016318|gb|AF238488.1JAF238488[17016318]
    • 2310: AF238487
      Homo sapiens olfactory-like receptor PJCG2 (PJCG2) mRNA, partial cds
      gi|17016316|gb|AF238487.1|AF238487[17016316]
    • 2311: AF220494
      Homo sapiens olfactory receptor-like protein JCG4 (JCG4) mRNA, partial cds
      gi|17016314|gb|AF220494.1|AF220494[17016314]
    • 2312: AF220493
      Homo sapiens olfactory receptor-like protein PJCG1 (PJCG1) mRNA, partial cds
      gi|17016312|gb|AF220493.1|AF220493[17016312]
    • 2313: AF209507
      Homo sapiens olfactory receptor-like protein mRNA, complete sequence
      gi|17016311|gb|AF209507.1|AF209507[17016311]
    • 2314: AF403014
      Homo sapiens type II gonadotropin-releasing hormone receptor gene, partial cds
      gi|16589055|gb|AF403014.1|AF403014[16589055]
    • 2316: AF403012
      Homo sapiens ribonucleoprotein RBM8 gene, complete cds
      gi|1658905|gb|AF403012.1|AF403012[16589051]
    • 2317: AY011601
      Homo sapiens cannabinoid receptor 1 (CNR1) gene, partial cds
      gi|12699807|gb|AY011601.1|[12699807]
    • 2318: AY011231
      Homo sapiens adenosine A3 receptor (ADORA3) gene, partial cds
      gi|12699245|gb|AY011231.1|[12699245]
    • 2319: AF400602
      Homo sapiens beta-glucan receptor isoform H (BGR) mRNA, complete cds, alternatively spliced
      gi|15986713|gb|AF400602.1|AF400602[15986713]
    • 2320: AF400601
      Homo sapiens beta-glucan receptor isoform G (BGR) mRNA, complete cds, alternatively spliced
      gi|15986711|gb|AF400601.1|AF400601[15986711]
    • 2321: AF400600
      Homo sapiens beta-glucan receptor isoform F (BGR) mRNA, complete cds, alternatively spliced
      gi|15986709|gb|AF400600.1|AF400600[15986709]
    • 2322: AF400599
      Homo sapiens beta-glucan receptor isoform E (BGR) mRNA, complete cds, alternatively spliced
      gi|15986707|gb|AF400599.1|AF400599[15986707]
    • 2323: AF400598
      Homo sapiens beta-glucan receptor isoform D (BGR) mRNA, complete cds, alternatively spliced
      gi|15986705|gb|AF400598.1|AF400598[15986705]
    • 2324: AF400597
      Homo sapiens beta-glucan receptor isoform C (BGR) mRNA, complete cds, alternatively spliced
      gi|15986703|gb|AF400597.1|AF400597[15986703]
    • 2325: AF400596
      Homo sapiens beta-glucan receptor isoform B (BGR) mRNA, complete cds, alternatively spliced
      gi|15986701|gb|AF400596.1|AF400596[15986701]
    • 2326: AF400595
      Homo sapiens beta-glucan receptor isoform A (BGR) mRNA, complete cds, alternatively spliced
      gi|15986699|gb|AF400595.1|AF400595[15986699]
    • 2329: AF162669
      Homo sapiens olfactory receptor-like protein JCG2 (JCG2) gene, complete cds
      gi|12002783|gb|AF162669.1|AF162669[12002783]
    • 2330: NM004895
      Homo sapiens cold autoinflammatory syndrome 1 (CIAS1), mRNA
      gi|4757727|ref|NM004895.1|[4757727]
    • 2331: AF409103
      Homo sapiens T-cell receptor VB3 CDR3 region mRNA, partial cds
      gi|15425973|gb|AF409103.1|AF409103[15425973]
    • 2332: NM033181
      Homo sapiens cannabinoid receptor 1 (brain) (CNR1), transcript variant 3, mRNA
      gi|15208647|ref|NM033181.1|[15208647]
    • 2333: AF373846
      Homo sapiens BAFF receptor mRNA, complete cds
      gi|15208474|gb|AF373846.1|AF373846[15208474]
    • 2334: AF361108
      Homo sapiens CRHF2 receptor beta-isoform mRNA, partial sequence, aberrantly spliced
      gi|14586959|gb|AF361108.1|AF361108[14586959]
    • 2335: NM005755
      Homo sapiens Epstein-Barr virus induced gene 3 (EBI3), mRNA
      gi|14577916|ref|NM005755.2|[14577916]
    • 2336: AF369794
      Homo sapiens B cell crosslinked IgM-activating sequence protein (BXMAS1) mRNA,
      complete cds
      gi|14278718|gb|AF369794.2|AF369794[14278718]
    • 2337: AF376725
      Homo sapiens lung seven transmembrane receptor 1 (LUSTR1) mRNA, complete cds
      gi|14248996|gb|AF376725.1|AF376725[14248996]
    • 2343: AF352324
      Homo sapiens killer cell Ig-like receptor KIR3DL7 (KIRC1) mRNA, complete cds
      gi|13560903|gb|AF352324.1|AF352324[13560903]
    • 2344: AJ249131
      Homo sapiens partiel mPR gene for progesterone membrane binding protein
      gi|6688178|emb|AJ249131.1|HSA249131[6688178]
    • 2345: S73474
      Homo sapiens folate receptor alpha isoform mRNA, partial cds
      gi|688233|gb|S73474.1|S73490S2[688233]
    • 2346: S73490
      Homo sapiens folate receptor alpha isoform mRNA, partial cds
      gi|688232|gb|S73490.1|S73490S1[688232]
    • 2347: S69142
      Homo sapiens T-cell receptor alpha-chain (TcR V alpha) mRNA, partial cds
      gi|545977|gb|S69142.1|S69142[545977]
    • 2348: S67401
      Homo sapiens T-cell receptor beta chain VDJ region (TCR Vbeta 7.1 Jbeta 2.3) mRNA, partial cds
      gi|455870gb|S67401.1|S67401[455870]
    • 2349: S62797
      Homo sapiens T cell receptor beta chain VDJ region (TcrVbeta 6) mRNA, TcrVbeta
      6.7a allele, partial cds
      gi|385951|gb|S62797.1|S62797[385951]
    • 2350: AF310685
      Homo sapiens ADP-glucose receptor gene, complete cds
      gi|16973448|gb|AF310685.1|AF310685[16973448]
    • 2351: NM057160
      Homo sapiens artemin (ARTN), transcript variant 3, mRNA
      gi|16950644|ref|NM057160.1|[16950644]
    • 2352: NM057091
      Homo sapiens artemin (ARTN), transcript variant 2, mRNA
      gi|16950642|ref|NM057091.1|[16950642]
    • 2353: NM057090
      Homo sapiens artemin (ARTN), transcript variant 4, mRNA
      gi|16950640|ref|NM057090.1|[16950640]
    • 2354: NM003976
      Homo sapiens artemin (ARTN), transcript variant 1, mRNA
      gi|16950639|ref|NM003976.2|[16950639]
    • 2355: NM053032
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 8, mRNA
      gi|16950624|ref|NM053032.1|[16950624]
    • 2356: NM053031
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 7, mRNA
      gi|16950622|ref|NM053031.1|[16950622]
    • 2357: NM053030
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 5, mRNA
      gi|16950620|ref|NM053030.1|[16950620]
    • 2358: NM053029
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 4, mRNA
      gi|16950618|ref|NM053029.1|[16950618]
    • 2359: NM053028
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 3B, mRNA
      gi|16950616|ref|NM053028.1|[16950616]
    • 2360: NM053027
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 3A, mRNA
      gi|16950614|ref|NM053027.1|[16950614]
    • 2361: NM053026
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 2, mRNA
      gi|16950612|ref|NM053026.1|[16950612]
    • 2362: NM053025
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 1, mRNA
      gi|16950610|ref|NM053025.1|[16950610]
    • 2363: NM005965
      Homo sapiens myosin, light polypeptide kinase (MYLK), transcript variant 6, mRNA
      gi|16950600|ref|NM005965.2|[16950600]
    • 2364: AF106202
      Homo sapiens endothelial cell protein C receptor precursor (EPCR) gene, promoter
      region and complete cds
      gi|16950557|gb|AF106202.2|AF106202[16950557]
    • 2365: AY033942
      Homo sapiens prostate-specific G protein-coupled receptor (PSGR) mRNA, complete
      cds
      gi|16943640|gb|AY033942.1|[16943640]
    • 2366: AF369708
      Homo sapiens prostate-specific G-protein coupled receptor mRNA, complete cds
      gi|13752563|gb|AF369708.1|AF369708[13752563]
    • 2368: AJ276204
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-C-8
      gi|9968287|emb|AJ276204.1|HSA276204[9968287]
    • 2369: AJ276203
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-C-7
      gi|9968285|emb|AJ276203.1|HSA276203[9968285]
    • 2370: AJ276202
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-C-6
      gi|9968266|emb|AJ276202.1|HSA276202[9968266]
    • 2371: AJ276201
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-C-5
      gi|9968264|emb|AJ276201.1|HSA276201[9968264]
    • 2372: AJ276200
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-C-4
      gi|9968262|emb|AJ276200.1|HSA276200[9968262]
    • 2373: AJ276199
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-C-3
      gi|9968260|emb|AJ276199.1|HSA276199[9968260]
    • 2374: AJ276198
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-C-2
      gi|9968258|emb|AJ276198.1|HSA276198[9968258]
    • 2375: AJ276197
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-C-1
      gi|9968256|emb|AJ276197.1|HSA276197[9968256]
    • 2376: AJ276196
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Gel-C
      gi|9968254|emb|AJ276196.1|HSA276196[9968254]
    • 2377: AJ276195
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-11
      gi|9968252|emb|AJ276195.1|HSA276195[9968252]
    • 2378: AJ276194
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-10
      gi|9968250|emb|AJ276194.1|HSA276194[9968250]
    • 2379: AJ276193
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-9
      gi|9968248|emb|AJ276193.1|HSA276193[9968248]
    • 2380: AJ276192
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-8
      gi|9968246|emb|AJ276192.1|HSA276192[9968246]
    • 2381: AJ276191
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-7
      gi|9968244|emb|AJ276191.1|HSA276191[9968244]
    • 2382: AJ276190
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-6
      gi|9968242|emb|AJ276190.1|HSA276190[9968242]
    • 2383: AJ276189
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-5
      gi|9968240|emb|AJ276189.1|HSA276189[9968240]
    • 2384: AJ276188
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-4
      gi|9968238|emb|AJ276188.1|HSA276188[9968238]
    • 2385: AJ276187
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-3
      gi|9968236|emb|AJ276187.1|HSA276187[9968236]
    • 2386: AJ276186
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-2
      gi|9968234|emb|AJ276186.1|HSA276186[9968234]
    • 2387: AJ276185
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Plasmid-B-1
      gi|9968232|emb|AJ276185.1|HSA276185[9968232]
    • 2388: AJ276184
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Gel-A2
      gi|9968230|emb|AJ276184.1|HSA276184[9968230]
    • 2389: AJ276183
      Homo sapiens partial mRNA for T-cell receptor beta-chain (TCRB gene) Gel-A1
      gi|9968228|emb|AJ276183.1|HSA276183[9968228]
    • 2390: NM005086
      Homo sapiens sarcospan (Kras oncogene-associated gene) (SSPN), mRNA
      gi|16933560|ref|NM005086.3|[16933560]
    • 2391: NM018153
      Homo sapiens tumor endothelial marker 8 (TEM8), transcript variant 3, mRNA
      gi|16933552|ref|NM018153.2|[16933552]
    • 2392: NM053034
      Homo sapiens tumor endothelial marker 8 (TEM8), transcript variant 2, mRNA
      gi|16933550|ref|NM053034.1|[16933550]
    • 2393: NM005929
      Homo sapiens antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 (MFI2), transcript variant 1, mRNA
      gi|16933549|ref|NM005929.3|[16933549]
    • 2394: NM033316
      Homo sapiens antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 (MFI2), transcript variant 2, mRNA
      gi|16933548|ref|NM033316.2|[16933548]
    • 2395: AF361473
      Homo sapiens magic roundabout mRNA, complete cds
      gi|16930357|gb|AF361473.1|AF361473[16930357]
    • 2396: NM032208
      Homo sapiens tumor endothelial marker 8 (TEM8), transcript variant 1, mRNA
      gi|14149903|ref|NM032208.1|[14149903]
    • 2397: NM007346
      Homo sapiens opioid growth factor receptor (OGFR), mRNA
      gi|6671492|ref|NM007346.1|[6671492]
    • 2398: BC017412
      Homo sapiens, leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2, clone MGC:27265 IMAGE:4618777, mRNA, complete cds
      gi|16924270|gb|BC017412.1|BC017412[16924270]
    • 2401: AF435588
      Homo sapiens melatonin receptor Me11a (MTNR1A) mRNA, partial cds
      gi|16904202|gb|AF435588.1|AF435588[16904202]
    • 2402: AF421380
      Homo sapiens anthrax toxin receptor mRNA, complete cds
      gi|16566412|gb|AF421380.1|AF421380[16566412]
    • 2403: AF291815
      Homo sapiens NK cell receptor (CS1) mRNA, complete cds
      gi|113021809 gb|AF291815.1|AF291815[13021809]
    • 2404: AF117899
      Homo sapiens LDLR-FUT fusion protein (LDLR-FUT) mRNA, complete cds
      gi|6739499|gb|AF117899.1|AF117899[6739499]
    • 2405: AF054013
      Homo sapiens lipoxin A4 receptor mRNA, complete cds
      gi|3047268|gb|AF054013.1|AF054013[3047268]
    • 2406: AF013250
      Homo sapiens leukocyte-associated Ig-like receptor-2 (LAIR-2) mRNA, complete cds
      gi|2352942|gb|AF013250.1|AF013250[2352942]
    • 2407: AF013249
      Homo sapiens leukocyte-associated Ig-like receptor-1 (LAIR-1) mRNA, complete cds
      gi|2352940gb|AF013249.1|AF013249[2352940]
    • 2409: AF326353
      Homo sapiens Src-like adapter protein-2 mRNA, complete cds
      gi|16797891|gb|AF326353.1|AF326353[16797891]
    • 2411: BC017065
      Homo sapiens, tumor necrosis factor receptor superfamily, member 6b, decoy, clone MGC:9587 IMAGE:3886635, mRNA, complete cds
      gi|16877637|gb|BC017065.1|BC017065[16877637]
    • 2412: BC016938
      Homo sapiens, neuromedin U receptor 2, clone MGC:21396 IMAGE:3852151, mRNA, complete cds
      gi|16877376|gb|BC016938.1|BC016938[16877376]
    • 2413: BC016860
      Homo sapiens, G protein-coupled receptor, family C, group 5, member C, clone MGC:17384 IMAGE:3904655, mRNA, complete cds
      gi|16877192|gb|BC016860.1|BC016860[16877192]
    • 2414: BC016692
      Homo sapiens, progesterone receptor membrane component 2, clone MGC:22407 IMAGE:4067832, mRNA, complete cds
      gi|16876813|gb|BC016692.1|BC016692[16876813]
    • 2415: AY026949
      Homo sapiens stresscopin mRNA, complete cds
      gi|15026913|gb|AY026949.1|[15026913]
    • 2416: AF285092
      Homo sapiens Bcl-2-like protein 10 mRNA, complete cds
      gi|9837265|gb|AF285092.1|AF285092[9837265]
    • 2417: D78579
      Homo sapiens NOR-1 mRNA for neuron derived orphan receptor, complete cds
      gi|1651190|dbj|D78579.1|D78579[1651190]
    • 2418: D38044
      Homo sapiens gene for Ah-receptor, partial cds, exons 7-9
      gi|532672|dbj|D538044.1|HUMAHRA[532672]
    • 2419: NM053278
      Homo sapiens G protein-coupled receptor 102 (GPR102), mRNA
      gi|16751916|ref|NM053278.1|[16751916]
    • 2420: NM030916
      Homo sapiens Ig superfamily receptor LNIR (LNIR), mRNA
      gi|16716338|ref|NM030916.1|[16716338]
    • 2421: AF403479
      Homo sapiens EWS/FLI1 activated transcript 2 protein mRNA, complete cds
      gi|16611777|gb|AF403479.1|AF403479[16611777]
    • 2422: NM053036
      Homo sapiens G protein-coupled receptor 74 (GPR74), mRNA
      gi|16604257|gb|BC053036.1|BC016004[16604257]
    • 2431: BC016004
      Homo sapiens, macrophage receptor with collagenous structure, clone MGC:27263 IMAGE:4618447, mRNA, complete cds
      gi|16359078|gb|BC016004.1|BC016004[16359078]
    • 2432: BC013827
      Homo sapiens, laminin receptor 1 (67 kD, ribosomal protein SA), clone MGC:17122
      IMAGE:3446816, mRNA, complete cds
      gi|16307601|gb|BC013827.1|BC013827[16307601]
    • 2433: BC001590
      Homo sapiens, cargo selection protein (mannose 6 phosphate receptor binding protein), clone MGC:2012 IMAGE:2987965, mRNA, complete cds
      gi|16306788|gb|BC001590.1|BC001590[16306788]
    • 2434: BC001492
      Homo sapiens, ciliary neurotrophic factor receptor, clone MGC:1774 IMAGE:3510004, mRNA, complete cds
      gi|16306633|gb|BC001492.1|BC001492[16306633]
    • 2435: BC015768
      Homo sapiens, interleukin 13 receptor, alpha 1, clone MGC:23204 IMAGE:4868206,
      mRNA, complete cds
      gi|16041774|gb|BC015768.1|BC015768[16041774]
    • 2436: BC015731
      Homo sapiens, leukocyte immunoglobulin-like receptor, subfamily B (with TM and
      ITIM domains), member 1, clone MGC:22968 IMAGE:4878915, mRNA, complete cds
      gi|16041710|gb|BC015731.1|BC015731[16041710]
    • 2437: BC015542
      Homo sapiens, poliovirus receptor, clone MGC:9603 IMAGE:3902226, mRNA, complete
      cds
      gi|15930222|gb|BC015542.1|BC015542[15930222]
    • 2439: BC015195
      Homo sapiens, Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, clone MGC:14717 IMAGE:4251469, mRNA, complete cds
      gi|15929529|gb|BC015195.1|BC015195[15929529]
    • 2440: BC014972
      Homo sapiens, interleukin 2 receptor, gamma (severe combined immunodeficiency),
      clone MGC:23116 IMAGE:4878734, mRNA, complete cds
      gi|15929027|gb|BC014972.1|BC014972[15929027]
    • 2441: BC014962
      Homo sapiens, GDNF family receptor alpha 1, clone MGC:23045 IMAGE:4874042, mRNA,
      complete cds
      gi|15929001|gb|BC014962.1|BC014962[15929001]
    • 2442: BC014960
      Homo sapiens, low density lipoprotein receptor defect C complementing, clone MGC:23019 IMAGE:4876271, mRNA, complete cds
      gi|15928995|gb|BC014960.1|BC014960[15928995]
    • 2443: BC013816
      Homo sapiens, platelet-activating factor receptor, clone MGC:17210 IMAGE:4343214, mRNA, complete cds
      gi|15489458|gb|BC013816.1|BC013816[15489458]
    • 2444: BC013780
      Homo sapiens, adenosine A2a receptor, clone MGC:21342 IMAGE:4385637, mRNA, complete cds
      gi|15489369|gb|BC013780.1|BC013780[15489369]
    • 2445: NM032551
      Homo sapiens G protein-coupled receptor 54 (GPR54), mRNA
      gi|14211846|ref|NM032551.1|[14211846]
    • 2446: AF329490
      Homo sapiens IFGP2 mRNA, complete cds
      gi|16506260|gb|AF329490.1|AF329490[16506260]
    • 2447: AF329488
      Homo sapiens IFGP1 mRNA, complete cds
      gi|16506256|gb|AF329488.1|AF329488[16506256]
    • 2448: NM000798
      Homo sapiens dopamine receptor D5 (DRD5), mRNA
      gi|16445405|ref|NM000798.2|[16445405]
    • 2449: NM000794
      Homo sapiens dopamine receptor D1 (DRD1), mRNA
      gi|16445404|ref|NM000794.2|[16445404]
    • 2450: NM000796
      Homo sapiens dopamine receptor D3 (DRD3), transcript variant a, mRNA
      gi|16445403|ref|NM000796.2|[16445403]
    • 2451: NM033663
      Homo sapiens dopamine receptor D3 (DRD3), transcript variant e, mRNA
      gi|16445401|ref|NM033663.1|[16445401]
    • 2452: NM033660
      Homo sapiens dopamine receptor D3 (DRD3), transcript variant d, mRNA
      gi|16445399|ref|NM033660.1|[16445399]
    • 2453: NM033659
      Homo sapiens dopamine receptor D3 (DRD3), transcript variant c, mRNA
      gi|16445397|ref|NM033659.1|[16445397]
    • 2454: NM033658
      Homo sapiens dopamine receptor D3 (DRD3), transcript variant b, mRNA
      gi|16445395|ref|NM033658.1|[16445395]
    • 2455: AJ298918
      Homo sapiens t(8;22) (p11;q11) translocation breakpoint, BCR/FGFR gene
      gi|16444915|emb|AJ298918.1|HSA298918[16444915]
    • 2456: AJ298917
      Homo sapiens partial mRNA for FGFR1/BCR chimaeric fusion peptide
      gi|16444913|emb|AJ298917.1|HSA298917[16444913]
    • 2457: AJ298916
      Homo sapiens partial mRNA for BCR/FGFR1 chimaeric fusion protein
      gi|16444911|emb|AJ298916.1|HSA298916[16444911]
    • 2458: AF325925
      Homo sapiens tandem motif downstream of INSRR gene, allele 2
      gi|13374363|gb|AF325925.1|AF325925[13374363]
    • 2459: AF325924
      Homo sapiens tandem motif downstream of INSRR gene, allele 1
      gi|13374362|gb|AF325924.1|AF325924[13374362]
    • 2460: NM014879
      Homo sapiens G protein-coupled receptor 105 (GPR105), mRNA
      gi|7661847|ref|NM014879.1|[7661847]
    • 2461: NM000797
      Homo sapiens dopamine receptor D4 (DRD4), mRNA
      gi|4503388|ref|NM000797.1|[4503388]
    • 2462: NM052962
      Homo sapiens class II cytokine receptor (IL22RA2), mRNA
      gi|16418458|ref|NM052962.1|[16418458]
    • 2463: NM052932
      Homo sapiens pro-oncosis receptor inducing membrane injury gene (PORIMIN), mRNA
      gi|16418408|ref|NM052932.1|[16418408]
    • 2464: NM052887
      Homo sapiens Toll-interleukin 1 receptor (TIR) domain-containing adapter protein
      (TIRAP), mRNA
      gi|16418398|ref|NM052887.1|[16418398]
    • 2465: NM018835
      Homo sapiens olfactory receptor, family 1, subfamily K, member 1 (OR1K1), mRNA
      gi|9256536|ref|NM018835.1|[9256536]
    • 2466: BC016141
      Homo sapiens, interleukin 1 receptor accessory protein, clone IMAGE:3920152, mRNA
      gi|16359373|gb|BC016141.1|BC016141[16359373]
    • 2467: AF177765
      Homo sapiens toll-like receptor 4 (TLR4) gene, TLR4A allele, complete cds
      gi|6175872|gb|AF177765.1|AF177765[6175872]
    • 2468: U11813
      Homo sapiens hepatocyte growth factor receptor precursor, mRNA, partial cds; alternatively spliced
      gi|530799|gb|U11813.1|HSU11813[530799]
    • 2469: BC009540
      Homo sapiens, G protein-coupled receptor 87, clone MGC:10065 IMAGE:3894333, mRNA, complete cds
      gi|16306940 gb|BC009540.1|BC009540[16306940]
    • 2474: AJ313162
      Homo sapiens mRNA for soluble cytokine class II receptor, long isoform (CRF2-S1
      gene)
      gi|16304592|emb|AJ313162.1|HSA313162[16304592]
    • 2475: AJ313161
      Homo sapiens mRNA for soluble cytokine class II receptor, short isoform (CRF2-S1
      gene)
      gi|16304590|emb|AJ313161.1|HSA313161[16304590]
    • 2476: AY048757
      Homo sapiens ATP-binding cassette transporter G1 (ABCG1) mRNA, complete cds, alternatively spliced
      gi|16304310|gb|AY048757.1|[16304310]
    • 2501: AJ313161
      Homo sapiens mRNA for soluble cytokine class II receptor, short isoform (CRF2-S1 gene)
      gi|16304590|emb|AJ313161.1|HSA313161[16304590]
    • 2502: AY048757
      Homo sapiens ATP-binding cassette transporter G1 (ABCG1) mRNA, complete cds, alternatively spliced
      gi|16304310|gb|AY048757.1|[16304310]
    • 2626: NM012068
      Homo sapiens activating transcription factor 5 (ATF5), mRNA
      gi|12597624|ref|NM012068.2|[12597624]
    • 2627: AF055084
      Homo sapiens very large G-protein coupled receptor-1 (VLGR1) mRNA, complete cds
      gi|5902965|gb|AF055084.1|AF055084[5902965]
    • 2629: AJ414821
      Homo sapiens partial IGVKL12 gene for immunoglobulin kappa chain variable region, donor TG, cell84
      gi|16215495|emb|AJ414821.2|HSA414821[16215495]
    • 2630: AY056048
      Homo sapiens receptor protein tyrosine kinase variant EphB4v1 (EPHB4) mRNA, complete cds, alternatively spliced
      gi|16209619|gb|AY056048.1|[16209619]
    • 2631: AY056047
      Homo sapiens receptor protein tyrosine kinase EphB4 (EPHB4) gene, complete cds,
      alternatively spliced
      gi|16209617|gb|AY056047.1|[16209617]
    • 2632: AY052490
      Homo sapiens NK cell receptor (KIR2DL4) mRNA, KIR2DL4-10A allele, partial cds
      gi|16209550|gb|AY052498.1|[16209550]
    • 2633: AY052497
      Homo sapiens NK cell receptor (KIR2DL4) mRNA, KIR2DL4-9A allele, partial cds
      gi|16209510|gb|AY052497.1|[16209510]
    • 2634: AY052496
      Homo sapiens truncated NK cell receptor (KIR2DL4) mRNA, KIR2DL4-9A allele, partial cds
      gi|16209507|gb|AY052496.1|[16209507]
    • 2635: AF267245
      Homo sapiens killer cell lectin-like receptor KLRF1-S3 (KLRF1) mRNA, complete cds., alternatively spliced
      gi|16151842|gb|AF267245.1|AF267245[16151842]
    • 2636: AF267244
      Homo sapiens killer cell lectin-like receptor KLRF1-S2 (KLRF1) mRNA, complete cds., alternatively spliced
      gi|16151840|gb|AF267244.1|AF267244[16151840]
    • 2637: NM033637
      Homo sapiens beta-transducin repeat containing (BTRC), transcript variant 1, mRNA
      gi|16117782|ref|NM033637.1|[16117782]
    • 3563: NM033050
      Homo sapiens G protein-coupled receptor 91 (GPR91), mRNA
      gi|14780893|ref|NM033050.1|[14780893]
    • 3564: NM023914
      Homo sapiens G protein-coupled receptor 86 (GPR86), mRNA
      gi|13194202|ref|NM023914.1|[13194202]
    • 3565: NM020402
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 10 (CHRNA10), mRNA
      gi|11138122|ref|NM020402.2|[11138122]
    • 3566: NM020370
      Homo sapiens G protein-coupled receptor 84 (GPR84), mRNA
      gi|9966838|ref|NM020370.1|[9966838]
    • 3567: NM012301
      Homo sapiens atrophin-1 interacting protein 1; activin receptor interacting protein 1 (KIAA0705), mRNA
      gi|6912461|ref|NM012301.1|[6912461]
    • 3568: AF208541
      Homo sapiens V1-vascular vasopressin receptor AVPRLA gene, promoter region and
      partial cds
      gi|658112|gb|AF208541.1|AF208541[6581121]
    • 3569: NM005756
      Homo sapiens G protein-coupled receptor 64 (GPR64), mRNA
      gi|5031732|ref|NM005756.1|[5031732]
    • 3570: NM003939
      Homo sapiens beta-transducin repeat containing (BTRC), transcript variant 2, mRNA
      gi|4502476|ref|NM003939.1|[4502476]
    • 3571: AH003597
      Homo sapiens A3 adenosine receptor (ADORA3) gene
      gi|1387984|gb|AH003597.1|SEG_HUMADOR0[1387984]
    • 3572: L77730
      Homo sapiens A3 adenosine receptor (ADORA3) gene, exon 2
      gi|387983|gb|L77730.1[HUMADOR02[1387983]
    • 3573: L77729
      Homo sapiens A3 adenosine receptor (ADORA3) gene, exon 1
      gi|1387982|gb|L77729.1|HUMADOR01[1387982]
    • 3574: AF000381
      Homo sapiens folate binding protein mRNA, partial cds
      gi|16041647|gb|AF000381.2|AF000381[16041647]
    • 3583: AY054974
      Homo sapiens RAE-1-like transcript 4 mRNA, complete cds
      gi|15990603|gb|AY054974.1|[15990603]
    • 3584: AF421855
      Homo sapiens interleukin 4 receptor (IL4R) gene, complete cds
      gi|15987825|gb|AF421855.1|AF421855[15987825]
    • 3585: AF359241
      Homo sapiens soluble truncated fibroblast growth factor receptor 4 (FGFR4) mRNA,
      complete cds
      gi|3877134|gb|AF359241.1|AF359241[13877134]
    • 3586: NM022148
      Homo sapiens cytokine receptor-like factor 2 (CRLF2), mRNA
      gi|13375623|ref|NM022148.1|[13375623]
    • 3587: AF179770
      Homo sapiens olfactory receptor (HSA8) gene, partial cds
      gi|7211542|gb|AF179770.1|AF179770[7211542]
    • 3590: AF179767
      Homo sapiens olfactory receptor (HSA5) gene, partial cds
      gi|7211538|gb|AF179767.1|AF179767[7211538]
    • 3591: AF179766
      Homo sapiens olfactory receptor (HSA3) gene, partial cds
      gi|7211536|gb|AF179766.1|AF179766[7211536]
    • 3596: AF179761
      Homo sapiens olfactory receptor (HSA12) gene, partial cds
      gi|7211530|gb|AF179761.1|AF179761[7211530]
    • 3597: AF179760
      Homo sapiens olfactory receptor (HSA10) gene, partial cds
      gi|7211528|gb|AF179760.1|AF179760[7211528]
    • 3598: AF179759
      Homo sapiens olfactory receptor (HSA1) gene, partial cds
      gi|7211526|gb|AF179759.1|AF179759[7211526]
    • 3599: D86962
      Human mRNA for KIAA0207 gene, complete cds
      gi|1503997|dbj|D86962.1D86962[1503997]
    • 3600: D13626
      Human mRNA for KIAA0001 gene, complete cds
      gi|285994|dbj|D13626.1|HUMRSC338[285994]
    • 3601: AY026770
      Homo sapiens lectin-like receptor 1B (DECTIN1) mRNA, complete cds, alternatively
      spliced
      gi|15967098|gb|AY026770.2|[15967098]
    • 3602: AY026769
      Homo sapiens lectin-like receptor 1 (DECTIN1) mRNA, complete cds
      gi|15967096|gb|AY026769.2|[15967096]
    • 3605: AJ344142
      Homo sapiens mRNA for putative MCP-1 chemokine receptor (CCR11 gene)
      gi|15919090|emb|AJ344142.1|HSA344142[15919090]
    • 3606: AY029770
      Homo sapiens CCK-B/gastrin receptor variant mRNA, complete cds, alternatively spliced
      gi|15911832|gb|AY029770.1|[15911832]
    • 3607: NM002821
      Homo sapiens PTK7 protein tyrosine kinase 7 (PTK7), mRNA
      gi|15826839|ref|NM002821.2|[15826839]
    • 3608: AF303576
      Homo sapiens G protein-coupled receptor 75 (GPR75) gene, exon 1
      gi|15824419|gb|AF303576.1|AF303576[15824419]
    • 3609: AB032427
      Homo sapiens VRL-2 mRNA for vanilloid receptor like channel-2, complete cds
      gi|15822824|dbj|AB032427.1|AB032427[15822824]
    • 3610: AY008280
      Homo sapiens histamine receptor H4 (H4) mRNA, complete cds
      gi|15822540|gb|AY008280.1|[15822540]
    • 3611: U40271
      Homo sapiens transmembrane receptor precursor (PTK7) mRNA, complete cds
      gi|15808058|gb|U40271.2|HSU40271[15808058]
    • 3612: NM000575
      Homo sapiens interleukin 1, alpha (IL1A), mRNA
      gi|13236493|ref|NM000575.1|[13236493]
    • 3615: NM014312
      Homo sapiens cortical thymocyte receptor (X. laevis CTX) like (CTXL), mRNA
      gi|7657000|ref|NM014312.1|[7657000]
    • 3616: AB032738
      Homo sapiens gene for chemokine receptor CXCR3, partial cds
      gi|7209698|dbj|AB032738.1|AB032738[7209698]
    • 3617: AB032737
      Homo sapiens gene for chemokine receptor CXCR3, partial cds
      gi|7209696|dbj|AB032737.1|AB032737[7209696]
    • 3618: AB032736
      Homo sapiens gene for chemokine receptor CXCR3, partial cds
      gi|7209694|dbj|AB032736.1|AB032736[7209694]
    • 3619: AB032735
      Homo sapiens gene for chemokine receptor CXCR3, partial cds
      gi|7209692|dbj|AB032735.1|AB032735[7209692]
    • 3620: AB032734
      Homo sapiens CXCR2 gene for IL-8 receptor type B, partial cds
      gi|7209690|dbj|AB032734.1|AB032734[7209690]
    • 3621: AB032733
      Homo sapiens CXCR2 gene for IL-8 receptor type B, partial cds
      gi|7209688|dbj|AB032733.1|AB032733[7209688]
    • 3622: AB032732
      Homo sapiens CXCR1 gene for IL-8 receptor type A, partial cds
      gi|7209686|dbj|AB032732.1|AB032732[7209686]
    • 3623: AB032731
      Homo sapiens CXCR1 gene for IL-8 receptor type A, partial cds
      gi|7209684|dbj|AB032731.1|AB032731[7209684]
    • 3624: AB032730
      Homo sapiens CXCR1 gene for IL-8 receptor type A, partial cds
      gi|7209682|dbj|AB032730.1|AB032730[7209682]
    • 3625: AB032729
      Homo sapiens CXCR1 gene for IL-8 receptor type A, partial cds
      gi|7209680|dbj|AB032729.1|AB032729[7209680]
    • 3626: AB032728
      Homo sapiens CXCR1 gene for IL-8 receptor type A, partial cds
      gi|7209678|dbj|AB032728.1|A]B032728[7209678]
    • 3628: AB030952
      Homo sapiens TNFR2 gene for tumor necrosis factor receptor 2, partial cds
      gi|6683135|dbj|AB030952.1|AB030952[6683135]
    • 3629: AB030951
      Homo sapiens TNFR2 gene for tumor necrosis factor receptor 2, partial cds
      gi|6683133|dbj|AB030951.1|AB030951[6683133]
    • 3630: AB030950
      Homo sapiens TNFR2 gene for tumor necrosis factor receptor 2, partial cds
      gi|6683131|dbj|AB030950.1|AB030950[6683131]
    • 3631: AB030949
      Homo sapiens TNFR2 gene for tumor necrosis factor receptor 2, partial cds
      gi|6683129|dbj|AB030949.1|AB030949[6683129]
    • 3632: AB023892
      Homo sapiens gene for b-chemokine receptor CCR4, complete cds
      gi|6467142|dbj|AB023892.1|AB023892[6467142]
    • 3633: AB023891
      Homo sapiens gene for b-chemokine receptor CCR4, complete cds
      gi|6467140|dbj|AB023891.1|AB023891[6467140]
    • 3634: AB023890
      Homo sapiens gene for b-chemokine receptor CCR4, complete cds
      gi|6467138|dbj|AB023890.1|AB023890[6467138]
    • 3635: AB023889
      Homo sapiens gene for b-chemokine receptor CCR4, complete cds
      gi|6467136|dbj|AB023889.1|AB023889[6467136]
    • 3636: AB023888
      Homo sapiens gene for b-chemokine receptor CCR4, complete cds
      gi|6467134|dbj|AB023888.1|AB023888[6467134]
    • 3637: AB023887
      Homo sapiens gene for b-chemokine receptor CCR3, complete cds
      gi|6467132|dbj|AB023887.1|AB023887[6467132]
    • 3638: AH008153
      Homo sapiens IL-1RI gene, complete sequence
      gi|5823144|gb|AH008153.1|SEG_HSAIL1R[5823144]
    • 3639: AF146427
      Homo sapiens interleukin-1 receptor type I (IL1R1) gene, exon 1c
      gi|5823143|gb|AF146427.1|HSAIL1R2[5823143]
    • 3640: AF146426
      Homo sapiens interleukin-1 receptor type I (IL1R1) gene, exon 1b and intron 1b
      gi|5823142|gb|AF146426.1|HSAIL1R1[5823142]
    • 3641: NM006691
      Homo sapiens extracellular link domain-containing 1 (XLKD1), mRNA
      gi|5729910|ref|NM006691.1|[5729910]
    • 3642: Z99761
      Homo sapiens gonadotrophin-releasing hormone receptor gene exon 2
      gi|5514748|emb|Z99761.2|HSGRHRX2[5514748]
    • 3643: Z99760
      Homo sapiens gonadotropin-releasing hormone receptor gene exon 1 variant 1
      gi|5514747|emb|Z99760.2|HSGRHRX1[5514747]
    • 3644: NM001250
      Homo sapiens tumor necrosis factor receptor superfamily, member 5 (TNFRSF5), mRNA
      gi|4507580|ref|NM001250.1|[4507580]
    • 3645: NM000406
      Homo sapiens gonadotropin-releasing hormone receptor (GNRHR), mRNA
      gi|4504058|ref|NM000406.1|[4504058]
    • 3646: Z99995
      Homo sapiens partial gonadotropin releasing hormone receptor gene
      gi|3334762|emb|Z99995.1|HSZ99995[3334762]
    • 3647: G16069
      928H1R CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 928H1 right arm, sequence tagged site
      gi|1825444|gb|G16069.1|G16069[1825444]
    • 3648: G16077
      817D6L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 817D6 left arm, sequence tagged site
      gi|1592357|gb|G16077.1|G16077[1592357]
    • 3649: G16076
      807B6L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 807B6 left arm, sequence tagged site
      gi|1592356|gb|G16076.1|G16076[1592356]
    • 3650: G16075
      940H12L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 940H12 left arm, sequence tagged site
      gi|1592355|gb|G16075.1|G16075[1592355]
    • 3651: G16074
      706A2L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 706A2 left arm, sequence tagged site
      gi|1592354|gb|G16074.1G16074[1592354]
    • 3652: G16073
      967A10L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 967A10 left arm, sequence tagged site
      gi|1592353|gb|G16073.1|G16073[1592353]
    • 3653: G16072
      816C10L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 816C10 left arm, sequence tagged site
      gi|1592352|gb|G16072.1G16072[1592352]
    • 3654: G16071
      765B8R CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 765B8 right arm, sequence tagged site
      gi|1592351|gb|G16071.1G16071[1592351]
    • 3655: G16070
      622F2R CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 622F2 right arm, sequence tagged site
      gi|1592350|gb|G16070.1|G16070[1592350]
    • 3656: G16068
      868H11L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 868H11 left arm, sequence tagged site
      gi|1592349|gb|G16068.1|G16068[1592349]
    • 3657: G16067
      662F2L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 662F2 left arm, sequence tagged site
      gi|1592348|gb|G16067.1|G16067[1592348]
    • 3658: G16066
      918D7R CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 918D7 right arm, sequence tagged site
      gi|1592347|gb|G16066.1|G16066[1592347]
    • 3659: G16065
      758C4R CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 758C4 right arm, sequence tagged site
      gi|1592346|gb|G16065.1|G16065[1592346]
    • 3660: G16064
      677D7L CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 677D7 left arm, sequence tagged site
      gi|1592345|gb|G16064.1|G16064[1592345]
    • 3663: L11238
      Homo sapiens platelet membrane glycoprotein V mRNA; complete cds
      gi|388759|gb|L11238.1|HUMGLYCOPR[388759]
    • 3665: AF406652
      Homo sapiens MyD88 adapter-like protein mRNA, complete cds
      gi|15528826|gb|AF406652.1|AF406652[15528826]
    • 4053: NM022059
      Homo sapiens chemokine (C-X-C motif) ligand 16 (CXCL16), mRNA
      gi|11545764|ref|NM022059.1|[11545764]
    • 4054: NM030956
      Homo sapiens toll-like receptor 10 (TLR10), mRNA
      gi|13569929|ref|NM030956.1|[13569929]
    • 4055: NM033358
      Homo sapiens caspase 8, apoptosis-related cysteine protease (CASP8), transcript
      variant E, mRNA
      gi|15718711|ref|NM033358.1|[15718711]
    • 4056: NM033357
      Homo sapiens caspase 8, apoptosis-related cysteine protease (CASP8), transcript
      variant D, mRNA
      gi|15718709|ref|NM033357.1|[15718709]
    • 4057: NM033356
      Homo sapiens caspase 8, apoptosis-related cysteine protease (CASP8), transcript
      variant C, mRNA
      gi|15718707|ref|NM033356.1|[15718707]
    • 4058: NM033355
      Homo sapiens caspase 8, apoptosis-related cysteine protease (CASP8), transcript
      variant B, mRNA
      gi|15718705|ref|NM033355.1|[15718705]
    • 4059: NM001228
      Homo sapiens caspase 8, apoptosis-related cysteine protease (CASP8), transcript
      variant A, mRNA
      gi|15718703|ref|NM001228.2|[15718703]
    • 4061: NM000024
      Homo sapiens adrenergic, beta-2-, receptor, surface (ADRB2), mRNA
      gi|15718673|ref|NM000024.3|[15718673]
    • 4062: NM000683
      Homo sapiens adrenergic, alpha-2C—, receptor (ADRA2C), mRNA
      gi|15718672|ref|NM000683.2|[15718672]
    • 4063: NM000682
      Homo sapiens adrenergic, alpha-2B-, receptor (ADRA2B), mRNA
      gi|5718671|ref|NM000682.2|[15718671]
    • 4064: NM000681
      Homo sapiens adrenergic, alpha-2A-, receptor (ADRA2A), mRNA
      gi|15718669|ref|NM000681.2|[15718669]
    • 4065: NM006179
      Homo sapiens neurotrophin 5 (neurotrophin 4/5) (NTF5), mRNA
      gi|15718666|ref|NM006179.2|[15718666]
    • 4066: L26458
      Homo sapiens T-cell receptor mRNA, partial sequence
      gi|432477|gb|L26458.1|HUMEBSH[432477]
    • 4067: L26457
      Homo sapiens T-cell receptor mRNA, partial sequence
      gi|432476|gb|L26457.1|HUMEBSG[432476]
    • 4068: L26456
      Homo sapiens T-cell receptor mRNA, partial sequence
      gi|432475|gb|L26456.1|HUMEBSF[432475]
    • 4069: L26455
      Homo sapiens T-cell receptor mRNA, partial sequence
      gi|432474|gb|L26455.1|HUMEBSE[432474]
    • 4070: L26454
      Homo sapiens T-cell receptor mRNA, partial sequence
      gi|432473|gb|L26454.1|HUMEBSD[432473]
    • 4071: L26453
      Homo sapiens T-cell receptor mRNA, partial sequence
      gi|432472|gb|L26453.1|HUMEBSC[432472]
    • 4072: L26452
      Homo sapiens T-cell receptor mRNA, partial sequence
      gi|432471|gb|L26452.1|HUMEBSB[432471]
    • 4073: L26451
      Homo sapiens T-cell receptor mRNA, partial sequence
      gi|432470|gb|L26451.1|HUMEBSA[432470]
    • 4074: AH009839
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      partial cds, alternatively spliced
      gi|15706245|gb|AH009839.2|[15706245]
    • 4075: AJ301610
      Homo sapiens mRNA for GluR6 kainate receptor (GRIK2 gene), isoform-b
      gi|15485591|emb|AJ301610.1|HSA301610[15485591]
    • 4076: AJ301609
      Homo sapiens partial mRNA for GluR6 kainate receptor (GRIK2 gene), exons 10, and 13
      gi|15485589|emb|AJ301609.1|HSA301609[15485589]
    • 4077: AJ301608
      Homo sapiens partial mRNA for GluR6 kainate receptor (GRIK2 gene), exons 11, and 14
      gi|15485587|emb|AJ301608.1|HSA301608[15485587]
    • 4078: AF196774
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      exon 8 and partial cds, alternatively spliced
      gi|10312084|gb|AF196774.1|AH009839S8[10312084]
    • 4079: AF196773
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      exon 7
      gi|10312083|gb|AF196773.1|AH009839S7[10312083]
    • 4080: AF196772
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      exon 6
      gi|10312082|gb|AF196772.1|AH009839S6[10312082]
    • 4081: AF252867
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      exon 6A and partial cds, alternatively spliced
      gi|10312081|gb|AF252867.1|AH009839S5[10312081]
    • 4082: AF196771
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      exon 5
      gi|10312080|gb|AF196771.1|AH009839S4[10312080]
    • 4083: AF196770
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      exon 4
      gi|10312079|gb|AF196770.1|AH009839S3[10312079]
    • 4084: AF196769
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      exon 3
      gi|10312078|gb|AF196769.1|AH009839S2[10312078]
    • 4085: AF196768
      Homo sapiens HVEC cell-cell adhesion molecule/herpesvirus receptor (HVEC) gene,
      exon 2
      gi|10312077|gb|AF196768.1|AH009839S1[10312077]
    • 4086: AF399937
      Homo sapiens melanin-concentrating hormone receptor MCH-R2 mRNA, complete cds
      gi|15667842|gb|AF399937.1|AF399937[15667842]
    • 4087: NM032405
      Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant D,
      mRNA
      gi|14602456|ref|NM032405.1|[14602456]
    • 4088: NM032404
      Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant C,
      mRNA
      gi|14602454|ref|NM032404.1|[14602454]
    • 4089: NM032401
      Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant B,
      mRNA
      gi|14602452|ref|NM032401.1|[14602452]
    • 4090: NM024022
      Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant A,
      mRNA
      gi|13173470|ref|NM024022.1|[13173470]
    • 4091: AY046418
      Homo sapiens brain immunoglobulin receptor precursor, mRNA, complete cds
      gi|15636797|gb|AY046418.1|[15636797]
    • 4092: AF069333
      Homo sapiens insulin-like growth factor II receptor (IGF2R) gene, partial cds
      gi|15628184|gb|AF069333.2|AF069333115628184]
    • 4093: AY029541
      Homo sapiens putative G protein-coupled receptor mRNA, complete cds
      gi|15626067|gb|AY029541.1|[15626067]
    • 4094: AF117819
      Homo sapiens bradykinin B1 receptor mRNA, partial cds and 3′-untranslated region
      gi|4325046|gb|AF117819.1|AF117819[4325046]
    • 4095: NM004624
      Homo sapiens vasoactive intestinal peptide receptor 1 (VIPR1), mRNA
      gi|15619005|ref|NM004624.2|[15619005]
    • 4096: AY042216
      Homo sapiens G protein-coupled receptor (MRGX4) gene, complete cds
      gi|15546067|gb|AY042216.1|[15546067]
    • 4097: AY042215
      Homo sapiens G protein-coupled receptor (MRGX3) gene, complete cds
      gi|15546065|gb|AY042215.1|[15546065]
    • 4098: AY042214
      Homo sapiens G protein-coupled receptor (MRGX2) gene, complete cds
      gi|15546063|gb|AY042214.1|[15546063]
    • 4099: AY042213
      Homo sapiens G protein-coupled receptor (MRGX1) gene, complete cds
      gi|1554606|gb|AY042213.1|[15546061]
    • 4100: Y11395
      Homo sapiens mRNA for lanthionine synthetase C-like protein 1 (LANCL1 gene)
      gi|2894085|emb|Y11395.1|HSRNAP40[2894085]
    • 4101: BC014108
      Homo sapiens, Fc fragment of IgE, low affinity II, receptor for (CD23A), clone
      MGC:20696 IMAGE:4309266, mRNA, complete cds
      gi|15559484|gb|BC014108.1|BC014108[15559484]
    • 4102: AF306329
      Homo sapiens neuronal nicotinic acetylcholine receptor beta 4 subunit (CHRNB4)
      gene, exon 6 and complete cds
      gi|15558964|gb|AF306329.1|AF306325S5[15558964]
    • 4103: AF306328
      Homo sapiens neuronal nicotinic acetylcholine receptor beta 4 subunit (CHRNB4)
      gene, exon 5
      gi|15558963|gb|AF306328.1|AF306325S4[15558963]
    • 4104: AF306327
      Homo sapiens neuronal nicotinic acetylcholine receptor beta 4 subunit (CHRNB4)
      gene, exons 3, 4, and 4a, alternatively spliced
      gi|15558962|gb|AF306327.1|AF306325S3[15558962]
    • 4105: AF306326
      Homo sapiens neuronal nicotinic acetylcholine receptor beta 4 subunit (CHRNB4)
      gene, exon 2
      gi|15558961|gb|AF306326.1|AF306325S2[15558961]
    • 4106: AF306325
      Homo sapiens neuronal nicotinic acetylcholine receptor beta 4 subunit (CHRNB4)
      gene, exon 1
      gi|15558960|gb|AF306325.1|AF306325S1[15558960]
    • 4107: AH011061
      Homo sapiens neuronal nicotinic acetylcholine receptor beta 4 subunit (CHRNB4)
      gene, complete cds
      gi|15558959|gb|AH011061.1|SEG_AF306325S[15558959]
    • 4108: AJ316282
      Homo sapiens partial TCRB gene for T cell receptor beta chain, allele TCRBV1J2S3, isolate P15SF, clone 9
      gi|15558855|emb|AJ316282.1|HSA316282[15558855]
    • 4109: AJ316281
      Homo sapiens partial TCRB gene for T cell receptor beta chain, allele TCRBV1J2S3, patient P22SF, clone 3
      gi|5558853|emb|AJ316281.1|HSA316281[15558853]
    • 4110: AJ316280
      Homo sapiens partial TCRB gene for T cell receptor beta chain, allele TCRBV1J2S3, patient P14SF, clone 1
      gi|15558851|emb|AJ316280.1|HSA316280[15558851]
    • 4111: NM001954
      Homo sapiens discoidin domain receptor family, member 1 (DDR1), transcript variant 2, mRNA
      gi|7669486|ref|NM001954.21[7669486]
    • 4112: NM013994
      Homo sapiens discoidin domain receptor family, member 1 (DDR1), transcript variant 3, mRNA
      gi|7669484|ref|NM013994.1|[7669484]
    • 4113: NM013993
      Homo sapiens discoidin domain receptor family, member 1 (DDR1), transcript variant 1, mRNA
      gi|7669482|ref|NM013993.1|[7669482]
    • 4114: AF325356
      Homo sapiens histamine receptor H4 (AXOR35) mRNA, complete cds
      gi|15553202|gb|AF325356.1|AF325356[15553202]
    • 4115: AF349574
      Homo sapiens interleukin 12 receptor beta 2 (IL12RB2) gene, partial sequence
      gi|15088551|gb|AF349574.1|AF349574[15088551]
    • 4116: NM014395
      Homo sapiens dual adaptor of phosphotyrosine and 3-phosphoinositides (DAPP1), mRNA
      gi|7657006|ref|NM014395.1|[7657006]
    • 4117: AY043466
      Homo sapiens Fc receptor-like protein 3 (FCRH3) mRNA, complete cds
      gi|15528834|gb|AY043466.1|[15528834]
    • 4118: AY043465
      Homo sapiens Fc receptor-like protein 2 (FCRH2) mRNA, complete cds
      gi|15528832|gb|AY043465.1|[15528832]
    • 4119: AY043464
      Homo sapiens Fc receptor-like protein 1 (FCRH1) mRNA, complete cds
      gi|15528830|gb|AY043464.1|[15528830]
    • 4120: AJ344350
      Homo sapiens partial IGDH3-9 gene segment, isolate case6-cell520
      gi|15528515|emb|AJ344350.1|HSA344350[15528515]
    • 4121: AJ344349
      Homo sapiens partial IGDH3-9 gene segment, isolate case5-cell49
      gi|15528514|emb|AJ344349.1|HSA344349[15528514]
    • 4122: AJ344348
      Homo sapiens partial IGDH6-25 gene segment, isolate case4-cell89
      gi|15528513|emb|AJ344348.1|HSA344348[15528513]
    • 4125: NM033135
      Homo sapiens spinal cord-derived growth factor-B (SCDGF-B), transcript variant
      2, mRNA
      gi|15451920|ref|NM033135.1|[15451920]
    • 4126: NM025208
      Homo sapiens spinal cord-derived growth factor-B (SCDGF-B), transcript variant
      1, mRNA
      gi|15451919|ref|NM025208.2|[15451919]
    • 4127: NM033346
      Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2), transcript variant 2, mRNA
      gi|15451917|ref|NM033346.1|[15451917]
    • 4128: NM001204
      Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2), transcript variant 1, mRNA
      gi|15451915|ref|NM001204.3|[15451915]
    • 4129: NM003933
      Homo sapiens BA11-associated protein 3 (BAIAP3), mRNA
      gi|15451913|ref|NM003933.3|[15451913]
    • 4130: NM002006
      Homo sapiens fibroblast growth factor 2 (basic) (FGF2), mRNA
      gi|15451897|ref|NM002006.2|[15451897]
    • 4131: NM000647
      Homo sapiens chemokine (C-C motif) receptor 2 (CCR2), transcript variant A, mRNA
      gi|15451896|ref|NM000647.2|[15451896]
    • 4132: NM004631
      Homo sapiens low density lipoprotein receptor-related protein 8, apolipoprotein
      e receptor (LRP8), transcript variant 1, mRNA
      gi|15451869|ref|NM004631.2|[15451869]
    • 4133: NM033300
      Homo sapiens low density lipoprotein receptor-related protein 8, apolipoprotein
      e receptor (LRP8), transcript variant 2, mRNA
      gi|15451867|ref|NM033300.1|[15451867]
    • 4134: NM017522
      Homo sapiens low density lipoprotein receptor-related protein 8, apolipoprotein
      e receptor (LRP8), transcript variant 3, mRNA
      gi|15451865|ref|NM017522.2|[15451865]
    • 4135: NM033337
      Homo sapiens caveolin 3 (CAV3), transcript variant 1, mRNA
      gi|15451859|ref|NM033337.1|[15451859]
    • 4136: NM001234
      Homo sapiens caveolin 3 (CAV3), transcript variant 2, mRNA
      gi|15451858|ref|NM001234.3|[15451858]
    • 4137: NM002609
      Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB),
      mRNA
      gi|15451788|ref|NM002609.2|[15451788]
    • 4138: NM006206
      Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA
      gi|15451787|ref|NM006206.2|[15451787]
    • 4139: NM000679
      Homo sapiens adrenergic, alpha-1B-, receptor (ADRA1B), mRNA
      gi|15451783|ref|NM000679.2|[15451783]
    • 4140: AY026771
      Homo sapiens lectin-like receptor 1C (DECTIN1) mRNA, complete cds, alternatively
      spliced
      gi|14278822|gb|AY026771.1|[14278822]
    • 4142: NM000648
      Homo sapiens chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, mRNA
      gi|4757937|ref|NM000648.1|[4757937]
    • 4143: AB041403
      Homo sapiens HTR1A gene for serotonin receptor 1A, complete cds
      gi|7592996|dbj|AB041403.1|AB041403[7592996]
    • 4144: NM015722
      Homo sapiens calcyon; D1 dopamine receptor-interacting protein (CALCYON), mRNA
      gi|9257200|ref|NM015722.2|[9257200]
    • 4145: AY044429
      Homo sapiens class II cytokine receptor (IL22RA2) mRNA, complete cds
      gi|15419022|gb|AY044429.1|[15419022]
    • 4148: AJ306388
      Homo sapiens mRNA for NTB-A receptor (KALI b gene)
      gi|15384842|emb|AJ306388.1|HSA306388[15384842]
    • 4149: AJ277141
      Homo sapiens mRNA for activating NK receptor (KALI gene)
      gi|15384840|emb|AJ277141.1|HSA277141[15384840]
    • 4150: NM033199
      Homo sapiens stresscopin-related peptide (SRP), mRNA
      gi|15082239|ref|NM033199.1|[15082239]
    • 4151: AB052684
      Homo sapiens mRNA for G1-coupled ADP receptor HORK3, complete cds
      gi|14422409|dbj|AB052684.1|AB052684[14422409]
    • 4152: AF227732
      Homo sapiens nicotinic acetylcholine receptor alpha 9 subunit mRNA, partial cds
      gi|7407124|gb|AF227732.1|AF227732[7407124]
    • 4153: NM005849
      Homo sapiens immunoglobulin superfamily, member 6 (IGSF6), mRNA
      gi|5031672|ref|NM005849.1|[5031672]
    • 4154: AF317654
      Homo sapiens G protein-coupled receptor (GPR63) gene, complete cds
      gi|15321723|gb|AF317654.2|AF317654[15321723]
    • 4155: AF399637
      Homo sapiens clone OR5B16 olfactory receptor gene, partial cds
      gi|15293858|gb|AF399637.1|AF399637[15293858]
    • 4156: AF399636
      Homo sapiens clone OR5B2 olfactory receptor gene, partial cds
      gi|15293856|gb|AF399636.1|AF399636[15293856]
    • 4157: AF399635
      Homo sapiens clone OR5AU1 olfactory receptor gene, partial cds
      gi|15293854|gb|AF399635.1|AF399635[15293854]
    • 4158: AF399634
      Homo sapiens clone OR10A3 olfactory receptor gene, partial cds
      gi|15293852|gb|AF399634.1|AF399634[15293852]
    • 4159: AF399633
      Homo sapiens clone OR13H1 olfactory receptor gene, partial cds
      gi|15293850|gb|AF399633.1|AF399633[15293850]
    • 4160: AF399632
      Homo sapiens clone OR2B3 olfactory receptor gene, partial cds
      gi|15293848|gb|AF399632.1|AF399632[15293848]
    • 4161: AF399631
      Homo sapiens clone OR2H2 olfactory receptor gene, partial cds
      gi|15293846|gb|AF399631.1|AF399631[15293846]
    • 4162: AF399630
      Homo sapiens clone OR2J3 olfactory receptor gene, partial cds
      gi|15293844|gb|AF399630.1|AF399630[15293844]
    • 4163: AF399629
      Homo sapiens clone OR2Y1 olfactory receptor gene, partial cds
      gi|15293842|gb|AF399629.1|AF399629[15293842]
    • 4164: AF399628
      Homo sapiens clone OR2W1 olfactory receptor gene, partial cds
      gi|15293840 gb|AF399628.1|AF399628[15293840]
    • 4165: AF399627
      Homo sapiens clone OR10C2 olfactory receptor gene, partial cds
      gi|5293838|gb|AF399627.1|AF399627[15293838]
    • 4166: AF399626
      Homo sapiens clone OR10A7 olfactory receptor gene, partial cds
      gi|15293836|gb|AF399626.1|AF399626[15293836]
    • 4167: AF399625
      Homo sapiens clone OR10A4 olfactory receptor gene, partial cds
      gi|15293834|gb|AF399625.1|AF399625[15293834]
    • 4168: AF399624
      Homo sapiens clone OR10A1 olfactory receptor gene, partial cds
      gi|15293832|gb|AF399624.1|AF399624[15293832]
    • 4169: AF399623
      Homo sapiens clone OR10A5 olfactory receptor gene, partial cds
      gi|15293830 gb|AF399623.1|AF399623[15293830]
    • 4170: AF399622
      Homo sapiens clone OR1K1 olfactory receptor gene, partial cds
      gi|15293828|gb|AF399622.1|AF399622[15293828]
    • 4171: AF399621
      Homo sapiens clone OR3A4 olfactory receptor gene, partial cds
      gi|5293826|gb|AF399621.1|AF399621[15293826]
    • 4172: AF399620
      Homo sapiens clone OR3A3 olfactory receptor gene, partial cds
      gi|15293824|gb|AF399620.1|AF399620[15293824]
    • 4173: AF399619
      Homo sapiens clone OR2Z2 olfactory receptor gene, partial cds
      gi|5293822|gb|AF399619.1|AF399619[15293822]
    • 4174: AF399618
      Homo sapiens clone OR2AG1 olfactory receptor gene, partial cds
      gi|15293820|gb|AF399618.1|AF399618[15293820]
    • 4175: AF399617
      Homo sapiens clone OR2M4 olfactory receptor gene, partial cds
      gi|5293818|gb|AF399617.1|AF399617[15293818]
    • 4176: AF399616
      Homo sapiens clone OR2M2 olfactory receptor gene, partial cds
      gi|15293816|gb|AF399616.1|AF399616[15293816]
    • 4177: AF399615
      Homo sapiens clone OR2M2 olfactory receptor gene, partial cds
      gi|15293814|gb|AF399615.1|AF399615[15293814]
    • 4178: AF399614
      Homo sapiens clone OR2V2 olfactory receptor gene, partial cds
      gi|15293812|gb|AF399614.1|AF399614[15293812]
    • 4179: AF399613
      Homo sapiens clone OR2T1 olfactory receptor gene, partial cds
      gi|15293810|gb|AF399613.1|AF399613[15293810]
    • 4180: AF399612
      Homo sapiens clone OR2T3 olfactory receptor gene, partial cds
      gi|15293808|gb|AF399612.1|AF399612[15293808]
    • 4181: AF399611
      Homo sapiens clone OR11H1 olfactory receptor gene, partial cds
      gi|5293806|gb|AF399611.1|AF399611[15293806]
    • 4182: AF399610
      Homo sapiens clone OR11G2 olfactory receptor gene, partial cds
      gi|15293804|gb|AF399610.1|AF399610[15293804]
    • 4183: AF399609
      Homo sapiens clone OR6Q1 olfactory receptor gene, partial cds
      gi|15293802|gb|AF399609.1|AF399609[15293802]
    • 4184: AF399608
      Homo sapiens clone OR6N1 olfactory receptor gene, partial cds
      gi|5293800|gb|AF399608.1|AF399608[15293800]
    • 4185: AF399607
      Homo sapiens clone OR6W1 olfactory receptor gene, partial cds
      gi|15293798|gb|AF399607.1|AF399607[15293798]
    • 4186: AF399606
      Homo sapiens clone OR6M1 olfactory receptor gene, partial cds
      gi|15293796|gb|AF399606.1|AF399606[15293796]
    • 4187: AF399605
      Homo sapiens clone OR6B1 olfactory receptor gene, partial cds
      gi|5293794|gb|AF399605.1|AF399605[15293794]
    • 4188: AF399604
      Homo sapiens clone OR6F1 olfactory receptor gene, partial cds
      gi|15293792|gb|AF399604.1|AF399604[15293792]
    • 4189: AF399603
      Homo sapiens clone OR13J1 olfactory receptor gene, partial cds
      gi|15293790|gb|AF399603.1|AF399603[15293790]
    • 4190: AF399602
      Homo sapiens clone OR13C4 olfactory receptor gene, partial cds
      gi|15293788|gb|AF399602.1|AF399602[15293788]
    • 4191: AF399601
      Homo sapiens clone OR2S2 olfactory receptor gene, partial cds
      gi|15293786|gb|AF399601.1|AF399601[15293786]
    • 4192: AF399600
      Homo sapiens clone OR13C7 olfactory receptor gene, partial cds
      gi|15293784|gb|AF399600.1|AF399600[15293784]
    • 4193: AF399599
      Homo sapiens clone OR13C8 olfactory receptor gene, partial cds
      gi|15293782|gb|AF399599.1|AF399599[15293782]
    • 4194: AF399598
      Homo sapiens clone OR2A7 olfactory receptor gene, partial cds
      gi|15293780|gb|AF399598.1|AF399598[15293780]
    • 4195: AF399597
      Homo sapiens clone OR2A1 olfactory receptor gene, partial cds
      gi|15293778|gb|AF399597.1|AF399597[15293778]
    • 4196: AF399596
      Homo sapiens clone OR2A6 olfactory receptor gene, partial cds
      gi|15293776|gb|AF399596.1|AF399596[15293776]
    • 4197: AF399595
      Homo sapiens clone OR2A5 olfactory receptor gene, partial cds
      gi|15293774|gb|AF399595.1|AF399595[15293774]
    • 4198: AF399594
      Homo sapiens clone OR2F1 olfactory receptor gene, partial cds
      gi|15293772|gb|AF399594.1|AF399594[15293772]
    • 4199: AF399593
      Homo sapiens clone OR10V1 olfactory receptor gene, partial cds
      gi|15293770|gb|AF399593.1|AF399593[15293770]
    • 4200: AF399592
      Homo sapiens clone OR2D3 olfactory receptor gene, partial cds
      gi|15293768|gb|AF399592.1|AF399592[15293768]
    • 4201: AF399591
      Homo sapiens clone OR2D2 olfactory receptor gene, partial cds
      gi|15293766|gb|AF399591.1|AF399591[15293766]
    • 4202: AF399590
      Homo sapiens clone OR5AY1 olfactory receptor gene, partial cds
      gi|15293764|gb|AF399590.1|AF399590[15293764]
    • 4203: AF399589
      Homo sapiens clone OR5AX1 olfactory receptor gene, partial cds
      gi|15293762|gb|AF399589.1|AF399589[15293762]
    • 4204: AF399588
      Homo sapiens clone OR10J6 olfactory receptor gene, partial cds
      gi|15293760|gb|AF399588.1|AF399588[15293760]
    • 4205: AF399587
      Homo sapiens clone OR10J1 olfactory receptor gene, partial cds
      gi|15293758|gb|AF399587.1|AF399587[15293758]
    • 4206: AF399586
      Homo sapiens clone OR10H4 olfactory receptor gene, partial cds
      gi|15293756|gb|AF399586.1|AF399586[15293756]
    • 4207: AF399585
      Homo sapiens clone OR10H2 olfactory receptor gene, partial cds
      gi|15293754|gb|AF399585.1|AF399585[15293754]
    • 4208: AF399584
      Homo sapiens clone OR10H1 olfactory receptor gene, partial cds
      gi|15293752|gb|AF399584.1|AF399584[15293752]
    • 4209: AF399583
      Homo sapiens clone OR10H5 olfactory receptor gene, partial cds
      gi|15293750|gb|AF399583.1|AF399583[15293750]
    • 4210: AF399582
      Homo sapiens clone OR10R2 olfactory receptor gene, partial cds
      gi|15293748|gb|AF399582.1|AF399582[15293748]
    • 4211: AF399581
      Homo sapiens clone OR4E2 olfactory receptor gene, partial cds
      gi|15293746|gb|AF399581.1|AF399581[15293746]
    • 4212: AF399580
      Homo sapiens clone OR4X2 olfactory receptor gene, partial cds
      gi|15293744|gb|AF399580.1|AF399580[15293744]
    • 4213: AF399579
      Homo sapiens clone OR4B1 olfactory receptor gene, partial cds
      gi|5293742|gb|AF399579.1|AF399579[15293742]
    • 4214: AF399578
      Homo sapiens clone OR4A15 olfactory receptor gene, partial cds
      gi|15293740|gb|AF399578.1|AF399578[15293740]
    • 4215: AF399577
      Homo sapiens clone OR4A4 olfactory receptor gene, partial cds
      gi|15293738|gb|AF399577.1|AF399577[15293738]
    • 4216: AF399576
      Homo sapiens clone OR4C12 olfactory receptor gene, partial cds
      gi|15293736|gb|AF399576.1|AF399576[15293736]
    • 4217: AF399575
      Homo sapiens clone OR4C13 olfactory receptor gene, partial cds
      gi|15293734|gb|AF399575.1|AF399575[15293734]
    • 4218: AF399574
      Homo sapiens clone OR4F4 olfactory receptor gene, partial cds
      gi|15293732|gb|AF399574.1|AF399574[15293732]
    • 4219: AF399573
      Homo sapiens clone OR4F15 olfactory receptor gene, partial cds
      gi|15293730|gb|AF399573.1|AF399573[15293730]
    • 4220: AF399572
      Homo sapiens clone OR4K14 olfactory receptor gene, partial cds
      gi|5293728|gb|AF399572.1|AF399572[15293728]
    • 4221: AF399571
      Homo sapiens clone OR4K3 olfactory receptor gene, partial cds
      gi|15293726|gb|AF399571.1|AF399571[15293726]
    • 4222: AF399570
      Homo sapiens clone OR4K1 olfactory receptor gene, partial cds
      gi|15293724|gb|AF399570.1|AF399570[15293724]
    • 4223: AF399569
      Homo sapiens clone OR4D6 olfactory receptor gene, partial cds
      gi|15293722|gb|AF399569.1|AF399569[15293722]
    • 4224: AF399568
      Homo sapiens clone OR4D2 olfactory receptor gene, partial cds
      gi|15293720|gb|AF399568.1|AF399568[15293720]
    • 4225: AF399567
      Homo sapiens clone OR4D1 olfactory receptor gene, partial cds
      gi|15293718|gb|AF399567.1|AF399567[15293718]
    • 4226: AF399566
      Homo sapiens clone OR10G3 olfactory receptor gene, partial cds
      gi|15293716|gb|AF399566.1|AF399566[15293716]
    • 4227: AF399565
      Homo sapiens clone OR10S1 olfactory receptor gene, partial cds
      gi|15293714|gb|AF399565.1|AF399565[15293714]
    • 4228: AF399564
      Homo sapiens clone OR1L8 olfactory receptor gene, partial cds
      gi|5293712|gb|AF399564.1|AF399564[15293712]
    • 4229: AF399563
      Homo sapiens clone OR1L6 olfactory receptor gene, partial cds
      gi|15293710|gb|AF399563.1|AF399563[15293710]
    • 4230: AF399562
      Homo sapiens clone OR1L4 olfactory receptor gene, partial cds
      gi|15293708|gb|AF399562.1|AF399562[15293708]
    • 4231: AF399561
      Homo sapiens clone ORIQI olfactory receptor gene, partial cds
      gi|15293706|gb|AF399561.1|AF399561[15293706]
    • 4232: AF399560
      Homo sapiens clone OR1C1 olfactory receptor gene, partial cds
      gi|15293704|gb|AF399560.1|AF399560[15293704]
    • 4233: AF399559
      Homo sapiens clone OR1F1 olfactory receptor gene, partial cds
      gi|15293702|gb|AF399559.1|AF399559[15293702]
    • 4234: AF399558
      Homo sapiens clone OR1F2 olfactory receptor gene, partial cds
      gi|15293700|gb|AF399558.1|AF399558[15293700]
    • 4235: AF399557
      Homo sapiens clone OR1S2 olfactory receptor gene, partial cds
      gi|15293698|gb|AF399557.1|AF399557[15293698]
    • 4236: AF399556
      Homo sapiens clone OR1A2 olfactory receptor gene, partial cds
      gi|15293696|gb|AF399556.1|AF399556[15293696]
    • 4237: AF399555
      Homo sapiens clone OR1A1 olfactory receptor gene, partial cds
      gi|15293694|gb|AF399555.1|AF399555[15293694]
    • 4238: AF399554
      Homo sapiens clone OR1J1 olfactory receptor gene, partial cds
      gi|15293692|gb|AF399554.1|AF399554[15293692]
    • 4239: AF399553
      Homo sapiens clone OR1J4 olfactory receptor gene, partial cds
      gi|5293690|gb|AF399553.1|AF399553[15293690]
    • 4240: AF399552
      Homo sapiens clone OR1J2 olfactory receptor gene, partial cds
      gi|15293688|gb|AF399552.1|AF399552[15293688]
    • 4241: AF399551
      Homo sapiens clone OR1E2 olfactory receptor gene, partial cds
      gi|15293686|gb|AF399551.1|AF399551[15293686]
    • 4242: AF399550
      Homo sapiens clone OR1E1 olfactory receptor gene, partial cds
      gi|15293684|gb|AF399550.1|AF399550[15293684]
    • 4243: AF399549
      Homo sapiens clone OR1M1 olfactory receptor gene, partial cds
      gi|15293682|gb|AF399549.1|AF399549[15293682]
    • 4244: AF399548
      Homo sapiens clone OR1I1 olfactory receptor gene, partial cds
      gi|5293680|gb|AF399548.1|AF399548[15293680]
    • 4245: AF399547
      Homo sapiens clone OR1N3 olfactory receptor gene, partial cds
      gi|15293678|gb|AF399547.1|AF399547[15293678]
    • 4246: AF399546
      Homo sapiens clone OR7C1 olfactory receptor gene, partial cds
      gi|15293676|gb|AF399546.1|AF399546[15293676]
    • 4247: AF399545
      Homo sapiens clone OR7C2 olfactory receptor gene, partial cds
      gi|15293674|gb|AF399545.1|AF399545[15293674]
    • 4248: AF399544
      Homo sapiens clone OR7A2 olfactory receptor gene, partial cds
      gi|15293672|gb|AF399544.1|AF399544[15293672]
    • 4249: AF399543
      Homo sapiens clone OR7A5 olfactory receptor gene, partial cds
      gi|15293670|gb|AF399543.1|AF399543[15293670]
    • 4250: AF399542
      Homo sapiens clone OR7A10 olfactory receptor gene, partial cds
      gi|15293668|gb|AF399542.1|AF399542[15293668]
    • 4251: AF399541
      Homo sapiens clone OR7A17 olfactory receptor gene, partial cds
      gi|15293666|gb|AF399541.1|AF399541[15293666]
    • 4252: AF399540
      Homo sapiens clone OR7G3 olfactory receptor gene, partial cds
      gi|15293664|gb|AF399540.1|AF399540[15293664]
    • 4253: AF399539
      Homo sapiens clone OR7G2 olfactory receptor gene, partial cds
      gi|15293662|gb|AF399539.1|AF399539[15293662]
    • 4254: AF399538
      Homo sapiens clone OR7G1 olfactory receptor gene, partial cds
      gi|15293660|gb|AF399538.1|AF399538[15293660]
    • 4255: AF399537
      Homo sapiens clone OR7D2 olfactory receptor gene, partial cds
      gi|15293658|gb|AF399537.1|AF399537[15293658]
    • 4256: AF399536
      Homo sapiens clone OR1N2 olfactory receptor gene, partial cds
      gi|15293656|gb|AF399536.1|AF399536[15293656]
    • 4257: AF399535
      Homo sapiens clone OR1D2 olfactory receptor gene, partial cds
      gi|15293654|gb|AF399535.1|AF399535[15293654]
    • 4258: AF399534
      Homo sapiens clone OR1D4 olfactory receptor gene, partial cds
      gi|15293652|gb|AF399534.1|AF399534[15293652]
    • 4259: AF399533
      Homo sapiens clone OR1D5 olfactory receptor gene, partial cds
      gi|15293650|gb|AF399533.1|AF399533[15293650]
    • 4260: AF399532
      Homo sapiens clone OR9Q1 olfactory receptor gene, partial cds
      gi|15293648|gb|AF399532.1|AF399532[15293648]
    • 4261: AF399531
      Homo sapiens clone OR9I1 olfactory receptor gene, partial cds
      gi|15293646|gb|AF399531.1|AF399531[15293646]
    • 4262: AF399530
      Homo sapiens clone OR9G4 olfactory receptor gene, partial cds
      gi|15293644|gb|AF399530.1|AF399530[15293644]
    • 4263: AF399529
      Homo sapiens clone OR5A2 olfactory receptor gene, partial cds
      gi|15293642|gb|AF399529.1|AF399529[15293642]
    • 4264: AF399528
      Homo sapiens clone OR5A1 olfactory receptor gene, partial cds
      gi|15293640|gb|AF399528.1|AF399528[15293640]
    • 4265: AF399527
      Homo sapiens clone OR5F1 olfactory receptor gene, partial cds
      gi|15293638|gb|AF399527.1|AF399527[15293638]
    • 4266: AF399526
      Homo sapiens clone OR5L2 olfactory receptor gene, partial cds
      gi|15293636|gb|AF399526.1|AF399526[15293636]
    • 4267: AF399525
      Homo sapiens clone OR5D18 olfactory receptor gene, partial cds
      gi|15293634|gb|AF399525.1|AF399525[15293634]
    • 4268: AF399524
      Homo sapiens clone OR5D16 olfactory receptor gene, partial cds
      gi|15293632|gb|AF399524.1|AF399524[15293632]
    • 4269: AF399523
      Homo sapiens clone OR5D14 olfactory receptor gene, partial cds
      gi|15293630|gb|AF399523.1|AF399523[15293630]
    • 4270: AF399522
      Homo sapiens clone OR5M1 olfactory receptor gene, partial cds
      gi|15293628|gb|AF399522.1|AF399522[15293628]
    • 4271: AF399521
      Homo sapiens clone OR5M11 olfactory receptor gene, partial cds
      gi|15293626|gb|AF399521.1|AF399521[15293626]
    • 4272: AF399520
      Homo sapiens clone OR5 MB olfactory receptor gene, partial cds
      gi|15293624|gb|AF399520.1|AF399520[15293624]
    • 4273: AF399519
      Homo sapiens clone OR5M9 olfactory receptor gene, partial cds
      gi|15293622|gb|AF399519.1|AF399519[15293622]
    • 4274: AF399518
      Homo sapiens clone OR5M3 olfactory receptor gene, partial cds
      gi|15293620|gb|AF399518.1|AF399518[15293620]
    • 4275: AF399517
      Homo sapiens clone OR8K1 olfactory receptor gene, partial cds
      gi|15293618|gb|AF399517.1|AF399517[15293618]
    • 4276: AF399516
      Homo sapiens clone OR8J3 olfactory receptor gene, partial cds
      gi|15293616|gb|AF399516.1|AF399516[15293616]
    • 4277: AF399515
      Homo sapiens clone OR8J1 olfactory receptor gene, partial cds
      gi|15293614|gb|AF399515.1|AF399515[15293614]
    • 4278: AF399514
      Homo sapiens clone OR5C1 olfactory receptor gene, partial cds
      gi|15293612|gb|AF399514.1|AF399514[15293612]
    • 4279: AF399513
      Homo sapiens clone OR8I2 olfactory receptor gene, partial cds
      gi|15293610|gb|AF399513.1|AF399513[15293610]
    • 4280: AF399512
      Homo sapiens clone OR8A1 olfactory receptor gene, partial cds
      gi|15293608|gb|AF399512.1|AF399512[15293608]
    • 4281: AF399511
      Homo sapiens clone OR8B12 olfactory receptor gene, partial cds
      gi|15293606|gb|AF399511.1|AF399511[15293606]
    • 4282: AF399510
      Homo sapiens clone OR8B8 olfactory receptor gene, partial cds
      gi|15293604|gb|AF399510.1|AF399510[15293604]
    • 4283: AF399509
      Homo sapiens clone OR8B4 olfactory receptor gene, partial cds
      gi|15293602|gb|AF399509.1|AF399509[15293602]
    • 4284: AF399508
      Homo sapiens clone OR8B2 olfactory receptor gene, partial cds
      gi|15293600|gb|AF399508.1|AF399508[15293600]
    • 4285: AF399507
      Homo sapiens clone OR8G1 olfactory receptor gene, partial cds
      gi|15293598|gb|AF399507.1|AF399507[15293598]
    • 4286: AF399506
      Homo sapiens clone OR6C1 olfactory receptor gene, partial cds
      gi|15293596|gb|AF399506.1|AF399506[15293596]
    • 4287: AF399505
      Homo sapiens clone OR52B2 olfactory receptor gene, partial cds
      gi|15293594|gb|AF399505.1|AF399505[15293594]
    • 4288: AF399504
      Homo sapiens clone OR52E6 olfactory receptor gene, partial cds
      gi|15293592|gb|AF399504.1|AF399504[15293592]
    • 4289: AF399503
      Homo sapiens clone OR51B2 olfactory receptor gene, partial cds
      gi|15293590|gb|AF399503.1|AF399503[15293590]
    • 4290: AF244813
      Homo sapiens platelet-derived growth factor C mRNA, complete cds
      gi|8886883|gb|AF244813.1|AF244813[8886883]
    • 4291: AF169650
      Homo sapiens high mobility group 1 protein (HMG1) gene, exon 5
      gi|14522864|gb|AF169650.1|AF169650[14522864]
    • 4451: AF330055
      Homo sapiens neuropeptide NPVF receptor mRNA, complete cds
      gi|15281399|gb|AF330055.1|AF330055[15281399]
    • 4452: AF330053
      Homo sapiens neuropeptide NPFF receptor mRNA, complete cds
      gi|15281395|gb|AF330053.1|AF330053[15281395]
    • 4453: AF402318
      Homo sapiens differentiation-related DIF14 long form (DIF14) mRNA, complete cds,
      alternatively spliced
      gi|15278166|gb|AF402318.1|AF402318[15278166]
    • 4454: AF397453
      Homo sapiens Fc receptor-like protein 5 (FCRH5) mRNA, complete cds
      gi|15277745|gb|AF397453.1|AF397453[15277745]
    • 4455: AF397452
      Homo sapiens Fc receptor-like protein 4 (FCRH4) mRNA, complete cds
      gi|15277740|gb|AF397452.1|AF397452[15277740]
    • 4456: AF400441
      Homo sapiens neurotrophic tyrosine kinase receptor type 2 (NTRK2) mRNA, complete
      cds
      gi|15217076|gb|AF400441.1|AF400441[15217076]
    • 4462: NM020535
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5 (KIR2DL5), mRNA
      gi|11968153|ref|NM020535.1|[11968153]
    • 4463: AP000511
      Homo sapiens genomic DNA, chromosome 6p21.3, HLA Class I region, section 10/20
      gi|5926698|dbj|AP000511.1|AP000511[5926698]
    • 4465: L20295
      Homo sapiens vasoactive intestinal peptide receptor mRNA, partial cds
      gi|403461|gb|L20295.1|HUMVAIPR[403461]
    • 4466: AY040568
      Homo sapiens interleukin 22-binding protein CRF2-10S (IL22BP) mRNA, complete cds, alternatively spliced
      gi|5212829|gb|AY040568.1|[15212829]
    • 4467: AY040567
      Homo sapiens interleukin 22-binding protein CRF2-10L (IL22BP) mRNA, complete cds, alternatively spliced
      gi|15212827|gb|AY040567.1|[15212827]
    • 4468: AY040566
      Homo sapiens interleukin 22-binding protein CRF2-10 (IL22BP) mRNA, complete cds
      gi|15212825|gb|AY040566.1|[15212825]
    • 4471: AX193708
      Sequence 30 from Patent WO0136467
      gi|15211557|emb|AX193708.1|AX193708[15211557]
    • 4472: AX193705
      Sequence 27 from Patent WO0136467
      gi|15211554|emb|AX193705.1|AX193705[15211554]
    • 4473: AX193702
      Sequence 24 from Patent WO0136467
      gi|15211551|emb|AX193702.1|AX193702[15211551]
    • 4474: AX193682
      Sequence 4 from Patent WO0136467
      gi|15211548|emb|AX193682.1|AX193682[15211548]
    • 4475: AX193679
      Sequence 1 from Patent WO0136467
      gi|15211545|emb|AX193679.1|AX193679[15211545]
    • 4476: NM005675
      Homo sapiens DiGeorge syndrome critical region gene 6 (DGCR6), mRNA
      gi|15208653|ref|NM005675.2|[15208653]
    • 4477: NM016083
      Homo sapiens cannabinoid receptor 1 (brain) (CNR1), transcript variant 2, mRNA
      gi|15208646|ref|NM016083.2|[15208646]
    • 4478: NM016205
      Homo sapiens platelet derived growth factor C (PDGFC), mRNA
      gi|9994186|ref|NM016205.1|[9994186]
    • 4479: AF159056
      Homo sapiens T-cell gamma receptor locus, complete sequence
      gi|5566238|gb|AF159056.1|AF159056[5566238]
    • 4480: NM006207
      Homo sapiens platelet-derived growth factor receptor-like (PDGFRL), mRNA
      gi|5453871|ref|NM006207.1|[5453871]
    • 4481: NM004986
      Homo sapiens kinectin 1 (kinesin receptor) (KTN1), mRNA
      gi|4826813|ref|NM004986.1|[4826813]
    • 4482: NM001840
      Homo sapiens cannabinoid receptor 1 (brain) (CNR1), transcript variant 1, mRNA
      gi|4502926|ref|NM001840.1|[4502926]
    • 4483: NM033223
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 3 (GABRG3), mRNA
      gi|15193297|ref|NM033223.1|[15193297]
    • 4484: AY008283
      Homo sapiens porimin mRNA, complete cds
      gi|15192138|gb|AY008283.1|[15192138]
    • 4485: NM015906
      Homo sapiens tripartite motif-containing 33 (TRIM33), transcript variant alpha,
      mRNA
      gi|14971412|ref|NM015906.2|[14971412]
    • 4486: NM033020
      Homo sapiens tripartite motif-containing 33 (TRIM33), transcript variant beta,
      mRNA
      gi|14971410|ref|NM033020.1|[14971410]
    • 4487: AH006431
      Homo sapiens glycine receptor alpha 2 subunit, complete cds
      gi|3598700|gb|AH006431.1|SEG_HSGLRA2G[3598700]
    • 4488: AF053495
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exon 9 and complete
      cds
      gi|3598699|gb|AF053495.1|HSGLRA2G9[3598699]
    • 4489: AF053494
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exon 8
      gi|3598698|gb|AF053494.1|HSGLRA2G8[3598698]
    • 4490: AF053493
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exon 7
      gi|3598697|gb|AF053493.1|HSGLRA2G7[3598697]
    • 4491: AF053492
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exon 6
      gi|3598696|gb|AF053492.1|HSGLRA2G6[3598696]
    • 4492: AF053491
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exon 5
      gi|3598695|gb|AF053491.1|HSGLRA2G5[3598695]
    • 4493: AF053490
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exon 4
      gi|3598694|gb|AF053490.1|HSGLRA2G4[3598694]
    • 4494: AF053489
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exons 3a and 3b
      gi|3598693|gb|AF053489.1|HSGLRA2G3[3598693]
    • 4495: AF053488
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exon 2
      gi|3598692|gb|AF053488.1|HSGLRA2G2[3598692]
    • 4496: AF053487
      Homo sapiens glycine receptor alpha 2 subunit (GLRA2) gene, exon 1
      gi|3598691|gb|AF053487.1|HSGLRA2G1[3598691]
    • 4499: AF344654
      Homo sapiens growth hormone receptor variant gene, partial cds
      gi|15186845|gb|AF344654.1|[15186845]
    • 4501: AF179680
      Homo sapiens apelin gene, complete cds
      gi|6708145|gb|AF179680.1|AF179680[6708145]
    • 4502: AJ296652
      Homo sapiens HRH3 gene for histamine h3 receptor, exons 1-3
      gi|15149878|emb|AJ296652.1|HSA296652[15149878]
    • 4503: NM006707
      Homo sapiens butyrophilin-like 3 (BTNL3), mRNA
      gi|5729747|ref|NM006707.1|[5729747]
    • 4504: NM002009
      Homo sapiens fibroblast growth factor 7 (keratinocyte growth factor) (FGF7), mRNA
      gi|15147344|ref|NM002009.2|[15147344]
    • 4505: AF190501
      Homo sapiens leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6)
      mRNA, partial cds
      gi|10441731|gb|AF190501.1|AF190501[10441731]
    • 4506: AF190500
      Homo sapiens leucine-rich repeat-containing G protein-coupled receptor 7 (LGR7)
      mRNA, complete cds
      gi|10441729|gb|AF190500.1|AF190500[10441729]
    • 4507: NM016543
      Homo sapiens sialic acid binding Ig-like lectin 7 (SIGLEC7), mRNA
      gi|7706570|ref|NM016543.1|[7706570]
    • 4508: NM014385
      Homo sapiens sialic acid binding Ig-like lectin 7 (SIGLEC7), mRNA
      gi|7657569|ref|NM014385.1|[7657569]
    • 4509: AC005153
      Homo sapiens PAC clone RP4-537P9 from 7p11.2-p12, complete sequence
      gi|3242766|gb|AC005153.1|AC005153[3242766]
    • 4528: AJ309020
      Homo sapiens mRNA for G protein-coupled receptor (AXOR12 gene)
      gi|14330412|emb|AJ309020.1|HSA309020[14330412]
    • 4529: AJ243297
      Homo sapiens partial RET gene, exons 2 to 20
      gi|5419752|emb|AJ243297.1|HSA243297[5419752]
    • 4530: X57019
      H. sapiens mRNA for tyrosine kinase receptor
      gi|37592|emb|X57019.1|HSUF025[37592]
    • 4585: AF166361
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 9 and complete cds
      gi|10086249|gb|AF166361.1|AF165901S9[10086249]
    • 4586: AF166360
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 8
      gi|10086248|gb|AF166360.1|AF165901S8[10086248]
    • 4587: AF166359
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 7
      gi|10086247|gb|AF166359.1|AF165901S7[10086247]
    • 4588: AF165906
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 6
      gi|10086246|gb|AF165906.1|AF165901S6[10086246]
    • 4589: AF165905
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 5
      gi|10086245|gb|AF165905.1|AF165901S5[10086245]
    • 4590: AF165904
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 4
      gi|10086244|gb|AF165904.1|AF165901S4[10086244]
    • 4591: AF165903
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 3
      gi|0086243|gb|AF165903.1|AF165901S3[10086243]
    • 4592: AF165902
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 2
      gi|10086242|gb|AF165902.1|AF165901S2[10086242]
    • 4593: AF165901
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, exon 1
      gi|10086241|gb|AF165901.1|AF165901S1[10086241]
    • 4594: AH009803
      Homo sapiens GABA receptor subunit alpha 3 (GABRA3) gene, complete cds
      gi|10086240|gb|AH009803.1|SEG_AF165901S[10086240]
    • 4595: AF167332
      Homo sapiens glutamate receptor subunit 3 flip and flop isoforms (GRIA3) gene,
      exon 16 and partial cds, alternatively spliced
      gi|9738978|gb|AF167332.1|F166362S15[9738978]
    • 4596: AF166375
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 15
      gi|9738977|gb|AF166375.1|F166362S14[9738977]
    • 4597: AF166374
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 14
      gi|9738976|gb|AF166374.1|F166362S13[9738976]
    • 4598: AF166373
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 13
      gi|9738975|gb|AF166373.1F166362S12[9738975]
    • 4599: AF166372
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 12
      gi|9738974|gb|AF166372.1|F166362S11[9738974]
    • 4600: AF166371
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 11
      gi|9738973|gb|AF166371.1|F166362S10[9738973]
    • 4601: AF166370
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 10
      gi|9738972|gb|AF166370.1|F166362S09[9738972]
    • 4602: AF166369
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 9
      gi|9738971|gb|AF166369.1F166362S08[9738971]
    • 4603: AF166368
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 8
      gi|9738970|gb|AF166368.1|F166362S07[9738970]
    • 4604: AF166367
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 7
      gi|9738969|gb|AF166367.1|F166362S06[9738969]
    • 4605: AF166366
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 6
      gi|9738968|gb|AF166366.1|F166362S05[9738968]
    • 4606: AF166365
      Homo sapiens glutamate receptor subunit 3 flip and flop isoforms (GRIA3) gene,
      exon 4 and partial cds
      gi|9738967|gb|AF166365.1|F166362S04[9738967]
    • 4607: AF166364
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 3
      gi|9738966|gb|AF166364.1|F166362S03[9738966]
    • 4608: AF166363
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 2
      gi|9738965|gb|AF166363.1|F166362S02[9738965]
    • 4609: AF166362
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 1
      gi|9738964|gb|AF166362.1|F166362S01[9738964]
    • 4610: AH009704
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, partial cds; and glutamate receptor subunit 3 (GRIA3) gene, partial cds, alternatively spliced
      gi|9738963|gb|AH009704.1|SEG_F166362S[9738963]
    • 4611: AF272389
      Homo sapiens natural killer cell immunoglobulin-like receptor (KIR2D55) mRNA, partial cds
      gi|15080894|gb|AF272389.1|AF272389[15080894]
    • 4612: BC011847
      Homo sapiens, fibroblast growth factor receptor 4, clone MGC:20292 IMAGE:4121396, mRNA, complete cds
      gi|15080147|gb|BC011847.1|BC011847[15080147]
    • 4613: BC011787
      Homo sapiens, nogo receptor, clone MGC:19831 IMAGE:4040540, mRNA, complete cds
      gi|15080004|gb|BC011787.1|BC011787[15080004]
    • 4614: AF353942
      Homo sapiens lantibiotic synthetase C-like protein 2 (LANCL2) mRNA, complete cds
      gi|15077638|gb|AF353942.1|AF353942[15077638]
    • 4615: AF343725
      Homo sapiens G-protein-coupled receptor GPR54 (GPR54) mRNA, complete cds
      gi|15077535|gb|AF343725.1|AF343725[15077535]
    • 4617: AJ272063
      Homo sapiens mRNA for vanilloid receptor 1 (VR1 gene)
      gi|15028818|emb|AJ272063.2|HSA272063[15028818]
    • 4618: AF133266
      Homo sapiens cysteinyl leukotriene receptor mRNA, complete cds
      gi|5359717|gb|AF133266.1|AF133266[5359717]
    • 4619: NM033130
      Homo sapiens sialic acid binding Ig-like lectin 10 (SIGLEC10), mRNA
      gi|15055512|ref|NM033130.1|[15055512]
    • 4620: NM033180
      Homo sapiens olfactory receptor, family 51, subfamily B, member 2 (OR51B2), mRNA
      gi|15042966|ref|NM033180.1|[15042966]
    • 4621: NM033179
      Homo sapiens olfactory receptor, family 51, subfamily B, member 4 (OR51B4), mRNA
      gi|15042964|ref|NM033179.1|[15042964]
    • 4622: AF380193
      Homo sapiens trace amine receptor 5 (TA5) gene, complete cds
      gi|14600089|gb|AF380193.1|AF380193[14600089]
    • 4623: AF380192
      Homo sapiens trace amine receptor 4 (TA4) gene, complete cds
      gi|14600087|gb|AF380192.1|AF380192[14600087]
    • 4624: AF380189
      Homo sapiens trace amine receptor 3 (TA3) gene, complete cds
      gi|14600081|gb|AF380189.1|AF380189[14600081]
    • 4625: AF380185
      Homo sapiens trace amine receptor 1 (TA1) gene, complete cds
      gi|14600073|gb|AF380185.1|AF380185[14600073]
    • 4626: AF313468
      Homo sapiens dendritic cell-associated C-type lectin-1 mRNA, complete cds
      gi|13649707|gb|AF313468.1|AF313468[13649707]
    • 4627: NM007096
      Homo sapiens clathrin, light polypeptide (Lca) (CLTA), transcript variant brain-specific, mRNA
      gi|6005992|ref|NM007096.1|[6005992]
    • 4628: NM001833
      Homo sapiens clathrin, light polypeptide (Lca) (CLTA), transcript variant nonbrain, mRNA
      gi|4502898|ref|NM001833.1|[4502898]
    • 4629: NM005292
      Homo sapiens G protein-coupled receptor 18 (GPR18), mRNA
      gi|15029527|ref|NM005292.1|[15029527]
    • 4630: NM012276
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4 (ILT7), mRNA
      gi|15029521|ref|NM012276.1|[15029521]
    • 4631: AJ299451
      Homo sapiens mRNA for glutamate receptor 7 (GRIK3 gene)
      gi|5028906|emb|AJ299451.1|HSA299451[15028906]
    • 4632: AY033606
      Homo sapiens fused in glioblastoma mRNA, complete cds
      gi|14289128|gb|AY033606.1|[14289128]
    • 4633: AF190696
      Homo sapiens bile salt export pump (ABCB11) gene, promoter region and partial sequence
      gi|14280234|gb|AF190696.1|AF190696[14280234]
    • 4634: NM018558
      Homo sapiens gamma-aminobutyric acid (GABA) receptor, theta (GABRQ), mRNA
      gi|8924257|ref|NM018558.1|[8924257]
    • 4635: NM014452
      Homo sapiens tumor necrosis factor receptor superfamily, member 21 (TNFRSF21),
      mRNA
      gi|7657038|ref|NM014452.1|[7657038]
    • 4637: AF320560
      Homo sapiens stresscopin-related protein mRNA, complete cds
      gi|14029393|gb|AF320560.1|AF320560[14029393]
    • 4638: NM007368
      Homo sapiens RAS p21 protein activator (GTPase activating protein) 3 (Ins(1,3,4,5)P4-binding protein) (GAP1IP4BP), mRNA
      gi|12545409|ref|NM007368.1|[12545409]
    • 4639: NM016109
      Homo sapiens angiopoietin-like 4 (ANGPTL4), mRNA
      gi|7705828|ref|NM016109.1|[7705828]
    • 4640: NM006667
      Homo sapiens progesterone receptor membrane component 1 (PGRMC1), mRNA
      gi|6857798|ref|NM006667.2|[6857798]
    • 4641: NM006320
      Homo sapiens progesterone receptor membrane component 2 (PGRMC2), mRNA
      gi|5453915|ref|NM006320.1|[5453915]
    • 4662: AF319553
      Homo sapiens TNFRSF19L mRNA, complete cds
      gi|15011026|gb|AF319553.1|AF319553[15011026]
    • 4663: AF395806
      Homo sapiens adrenergic receptor alpha-1a (ADRA1A) mRNA, complete cds
      gi|15004693|gb|AF395806.1|AF395806[15004693]
    • 4664: AF388194
      Homo sapiens PML/RARA fusion mRNA, partial sequence
      gi|15004544|gb|AF388194.1|AF388194[15004544]
    • 4665: AF388193
      Homo sapiens PML/RARA fusion mRNA, partial sequence
      gi|15004543|gb|AF388193.1|AF388193[15004543]
    • 4666: AF334818
      Homo sapiens sodium-dependent neutral amino acid transporter type 2 truncated isoform (ASCT2) mRNA, partial cds
      gi|15004316|gb|AF334818.1|AF334818[15004316]
    • 4667: NM022788
      Homo sapiens Purinergic receptor P2Y, G protein-coupled, 12 (P2RY12), mRNA
      gi|12232482|ref|NM022788.1|[12232482]
    • 4668: NM016523
      Homo sapiens killer cell lectin-like receptor subfamily F, member 1 (KLRF1), mRNA
      gi|7705573|ref|NM016523.1|[7705573]
    • 4669: NM002558
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 1 (P2RX1), mRNA
      gi|4505544|ref|NM002558.1|[4505544]
    • 4670: AF391809
      Homo sapiens coagulation factor II (thrombin) receptor (F2R) gene, complete cds
      gi|14971463|gb|AF391809.2|AF391809[14971463]
    • 4671: NM016930
      Homo sapiens syntaxin 18 (STX18), mRNA
      gi|8394375|ref|NM016930.1|[8394375]
    • 4672: NM032957
      Homo sapiens tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), transcript variant 1, mRNA
      gi|14790173|ref|NM032957.1|[14790173]
    • 4673: NM032945
      Homo sapiens tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), transcript variant M68C, mRNA
      gi|14790169|ref|NM032945.1|[14790169]
    • 4674: NM015647
      Homo sapiens tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), transcript variant 3, mRNA
      gi|14790156|ref|NM015647.2|[14790156]
    • 4675: NM005409
      Homo sapiens small inducible cytokine subfamily B (Cys-X-Cys), member 11 (SCYB11), mRNA
      gi|14790145|ref|NM005409.3|[14790145]
    • 4676: NM001305
      Homo sapiens claudin 4 (CLDN4), mRNA
      gi|14790131|ref|NM001305.2|[14790131]
    • 4677: NM004346
      Homo sapiens caspase 3, apoptosis-related cysteine protease (CASP3), transcript
      variant alpha, mRNA
      gi|14790118|ref|NM004346.2|[14790118]
    • 4678: NM032991
      Homo sapiens caspase 3, apoptosis-related cysteine protease (CASP3), transcript
      variant beta, mRNA
      gi|14790114|ref|NM032991.1|[14790114]
    • 4679: NM033057
      Homo sapiens olfactory receptor, family 2, subfamily B, member 2 (OR2B2), mRNA
      gi|14780899|ref|NM033057.1|[14780899]
    • 4680: NM020137
      Homo sapiens GRIP-associated protein 1 (GRASP1), mRNA
      gi|14719405|ref|NM020137.1|[14719405]
    • 4681: NM032503
      Homo sapiens G protein-coupled receptor slt (SLT), mRNA
      gi|14210483|ref|NM032503.1|[14210483]
    • 4682: AF260738
      Homo sapiens platelet-derived growth factor C (PDGFC) mRNA, complete cds
      gi|14009503|gb|AF260738.1|AF260738[14009503]
    • 4683: AF326275
      Homo sapiens melanocortin 1 receptor (MC1R) gene, complete cds
      gi|12658397|gb|AF326275.1|AF326275[12658397]
    • 4684: NM016434
      Homo sapiens tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), transcript variant 2, mRNA
      gi|7706540|ref|NM016434.1|[7706540]
    • 4685: NM013314
      Homo sapiens B-cell linker (BLNK), mRNA
      gi|7019534|ref|NM013314.1|[7019534]
    • 4686: NM005817
      Homo sapiens cargo selection protein (mannose 6 phosphate receptor binding protein) (TIP47), mRNA
      gi|5032182|ref|NM005817.1|[5032182]
    • 4687: NM003110
      Homo sapiens Sp2 transcription factor (SP2), mRNA
      gi|4507166|ref|NM003110.1|[4507166]
    • 4688: NM002704
      Homo sapiens pro-platelet basic protein (includes platelet basic protein, beta-thromboglobulin, connective tissue-activating peptide III, neutrophil-activating peptide-2) (PPBP), mRNA
      gi|4505980|ref|NM002704.1|[4505980]
    • 4689: AF064083
      Homo sapiens T-cell receptor beta chain variable region (TCRBV28) mRNA, TCRBV28*S2 allele, partial cds
      gi|3859856|gb|AF064083.1|AF064083[3859856]
    • 4690: BC010641
      Homo sapiens, gamma-aminobutyric acid (GABA) A receptor, beta 3, clone MGC:9051
      IMAGE:3871111, mRNA, complete cds
      gi|14714964|gb|BC010641.1|BC010641[14714964]
    • 4691: BC010574
      Homo sapiens, glutamate receptor, ionotropic, AMPA2 (alpha 2), clone MGC:17079
      IMAGE:4215347, mRNA, complete cds
      gi|14714845|gb|BC010574.1|BC010574[14714845]
    • 4692: BC010536
      Homo sapiens, coxsackie virus and adenovirus receptor, clone MGC:17118 IMAGE:3456544, mRNA, complete cds
      gi|14714774|gb|BC010536.1|BC010536[14714774]
    • 4693: BC010423
      Homo sapiens, Ig superfamily receptor LNIR, clone MGC:15117 IMAGE:3610849, mRNA,
      complete cds
      gi|14714573|gb|BC010423.1|BC010423[14714573]
    • 4694: BC010418
      Homo sapiens, laminin receptor 1 (67 kD, ribosomal protein SA), clone MGC:16557
      IMAGE:4079845, mRNA, complete cds
      gi|14714563|gb|BC010418.1|BC010418[14714563]
    • 4695: NM020168
      Homo sapiens p21(CDKN1A)-activated kinase 6 (PAK6), mRNA
      gi|14670348|ref|NM020168.2|[14670348]
    • 4696: BC010140
      Homo sapiens, tumor necrosis factor receptor superfamily, member 1A, clone MGC:19588 IMAGE:4131360, mRNA, complete cds
      gi|14603367|gb|BC010140.1|BC010140[14603367]
    • 4697: BC010054
      Homo sapiens, laminin receptor 1 (67 kD, ribosomal protein SA), clone MGC:19795
      IMAGE:3845335, mRNA, complete cds
      gi|14603183|gb|BC010054.1|BC010054[14603183]
    • 4698: BC009974
      Homo sapiens, laminin receptor 1 (67 kD, ribosomal protein SA), clone MGC:16607
      IMAGE:4110990, mRNA, complete cds
      gi|14602973|gb|BC009974.1|BC009974[14602973]
    • 4699: BC009960
      Homo sapiens, interleukin 13 receptor, alpha 1, clone MGC:15228 IMAGE:4300487, mRNA, complete cds
      gi|14602931|gb|BC009960.1|BC009960[14602931]
    • 4701: BC009877
      Homo sapiens, purinergic receptor P2Y, G-protein coupled, 11, clone MGC:16468 IMAGE:3953307, mRNA, complete cds
      gi|14602717|gb|BC009877.1|BC009877[14602717]
    • 4702: BC009861
      Homo sapiens, super conserved receptor expressed in brain 3, clone MGC:16375 IMAGE:3936037, mRNA, complete cds
      gi|14602675|gb|BC009861.1|BC009861[14602675]
    • 4703: BC009748
      Homo sapiens, dopamine receptor D5, clone MGC:10601 IMAGE:3928370, mRNA, complete cds
      gi|14602484|gb|BC009748.1|BC009748[14602484]
    • 4705: BC009391
      Homo sapiens, pyrimidinergic receptor P2Y, G-protein coupled, 6, clone MGC:15335
      IMAGE:4128941, mRNA, complete cds
      gi|14424757|gb|BC009391.1|BC009391[14424757]
    • 4707: BC009237
      Homo sapiens, thyroid stimulating hormone receptor, clone MGC:2216 IMAGE:2989823, mRNA, complete cds
      gi|14328043|gb|3BC009237.1|BC009237[14328043]
    • 4708: BC008982
      Homo sapiens, complement component 5 receptor 1 (C5a ligand), clone MGC:17119 IMAGE:4177114, mRNA, complete cds
      gi|14290435|gb|BC008982.1|BC008982[14290435]
    • 4709: BC008867
      Homo sapiens, laminin receptor 1 (67 kD, ribosomal protein SA), clone MGC:16750
      IMAGE:4130936, mRNA, complete cds
      gi|14250793|gb|BC008867.1|BC008867[14250793]
    • 4710: BC008786
      Homo sapiens, integrin, alpha 5 (fibronectin receptor, alpha polypeptide), clone
      MGC:3697 IMAGE:3629647, mRNA, complete cds
      gi|14250643|gb|BC008786.1|BC008786[14250643]
    • 4711: BC008770
      Homo sapiens, G protein-coupled receptor 56, clone MGC:1409 IMAGE:3139174, mRNA,
      complete cds
      gi|14250619|gb|BC008770.1|BC008770[14250619]
    • 4712: BC008734
      Homo sapiens, Fc fragment of IgG, receptor, transporter, alpha, clone MGC:1506
      IMAGE:3163446, mRNA, complete cds
      gi|14250560|gb|BC008734.1|BC008734[14250560]
    • 4714: BC008716
      Homo sapiens, discoidin domain receptor family, member 1, clone MGC:8681 IMAGE:2964574, mRNA, complete cds
      gi|14250529|gb|BC008716.1|BC008716[14250529]
    • 4715: BC008406
      Homo sapiens, CD36 antigen (collagen type I receptor, thrombospondin receptor),
      clone MGC:14530 IMAGE:4244251, mRNA, complete cds
      gi|14250019|gb|BC008406.1|BC008406[14250019]
    • 4716: NM032571
      Homo sapiens EGF-like module-containing mucin-like receptor EMR3 (EMR3), mRNA
      gi|14211882|ref|NM032571.1|[14211882]
    • 4717: AF345568
      Homo sapiens putative chemokine receptor (FKSG80) mRNA, complete cds
      gi|13517963|gb|AF345568.1|AF345568[13517963]
    • 4718: AF345567
      Homo sapiens putative purinergic receptor (FKSG79) mRNA, complete cds
      gi|13517961|gb|AF345567.1|AF345567[13517961]
    • 4719: AF345566
      Homo sapiens putative G-protein-coupled receptor FKSG78 (FKSG78) mRNA, complete
      cds
      gi|3517959|gb|AF345566.1|AF345566[13517959]
    • 4720: AF345565
      Homo sapiens putative G-protein-coupled receptor FKSG77 (FKSG77) mRNA, complete
      cds
      gi|13517957|gb|AF345565.1|AF345565[13517957]
    • 4722: NM013447
      Homo sapiens egf-like module containing, mucin-like, hormone receptor-like sequence 2 (EMR2), mRNA
      gi|7305024|ref|NM013447.1|[7305024]
    • 4724: BC007720
      Homo sapiens, 5-hydroxytryptamine (serotonin) receptor 1D, clone MGC:12645 IMAGE:4299633, mRNA, complete cds
      gi|14043458|gb|BC007720.1|BC007720[14043458]
    • 4725: BC007713
      Homo sapiens, protein tyrosine phosphatase, receptor type, N, clone MGC:12646 IMAGE:4130827, mRNA, complete cds
      gi|14043446|gb|BC007713.1|BC007713[14043446]
    • 4727: BC007566
      Homo sapiens, cargo selection protein (mannose 6 phosphate receptor binding protein), clone MGC:15516 IMAGE:3028104, mRNA, complete cds
      gi|14043156|gb|BC007566.1|BC007566[14043156]
    • 4728: BC007408
      Homo sapiens, low density lipoprotein receptor-related protein 3, clone MGC:2428
      IMAGE:3009711, mRNA, complete cds
      gi|13938518|gb|BC007408.1|BC007408[13938518]
    • 4729: BC006196
      Homo sapiens, tumor necrosis factor receptor superfamily, member 9, clone MGC:2172 IMAGE:2924109, mRNA, complete cds
      gi|13623200|gb|BC006196.1|BC006196[13623200]
    • 4730: BC005912
      Homo sapiens, Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, clone MGC:14507 IMAGE:4294467, mRNA, complete cds
      gi|13543505|gb|BC005912.1|BC005912[13543505]
    • 4731: BC005818
      Homo sapiens, cargo selection protein (mannose 6 phosphate receptor binding protein), clone MGC:11117 IMAGE:3833411, mRNA, complete cds
      gi|13543306|gb|BC005818.1|BC005818[13543306]
    • 4732: BC005391
      Homo sapiens, laminin receptor 1 (67 kD, ribosomal protein SA), clone MGC:12521
      IMAGE:3997019, mRNA, complete cds
      gi|13529268|gb|BC005391.1|BC005391[13529268]
    • 4733: BC005333
      Homo sapiens, interferon gamma receptor 1, clone MGC:12420 IMAGE:3950528, mRNA,
      complete cds
      gi|13529118|gb|BC005333.1|BC005333[13529118]
    • 4734: BC005315
      Homo sapiens, formyl peptide receptor 1, clone MGC:12392 IMAGE:3829614, mRNA, complete cds
      gi|13529064|gb|BC005315.1|BC005315[13529064]
    • 4735: BC005268
      Homo sapiens, putative receptor protein, clone MGC:12310 IMAGE:4051155, mRNA, complete cds
      gi|13528953|gb|BC005268.1|BC005268[13528953]
    • 4737: BC004555
      Homo sapiens, G protein-coupled receptor, clone MGC:10314 IMAGE:4054377, mRNA,
      complete cds
      gi|13528716|gb|BC004555.1|BC004555[13528716]
    • 4738: BC004553
      Homo sapiens, receptor-interacting serine-threonine kinase 2, clone MGC:10684 IMAGE:4026156, mRNA, complete cds
      gi|13528713|gb|BC004553.1|BC004553[13528713]
    • 4739: BC004545
      Homo sapiens, leukotriene b4 receptor (chemokine receptor-like 1), clone MGC:10388 IMAGE:3946189, mRNA, complete cds
      gi|13528695|gb|BC004545.1|BC004545[13528695]
    • 4740: BC004899
      Homo sapiens, sigma receptor (SR31747 binding protein 1), clone MGC:3851 IMAGE:3529352, mRNA, complete cds
      gi|13436169|gb|BC004899.1|BC004899[13436169]
    • 4741: BC004348
      Homo sapiens, interleukin 21 receptor, clone MGC:10967 IMAGE:3634520, mRNA, complete cds
      gi|13279298|gb|BC004348.1|BC004348[13279298]
    • 4742: BC003684
      Homo sapiens, coxsackie virus and adenovirus receptor, clone MGC:5086 IMAGE:3463613, mRNA, complete cds
      gi|13277551|gb|BC003684.1|BC003684[13277551]
    • 4743: BC003624
      Homo sapiens, interferon gamma receptor 2 (interferon gamma transducer 1), clone
      MGC:2193 IMAGE:2967074, mRNA, complete cds
      gi|13177681|gb|BC003624.1|BC003624[13177681]
    • 4744: BC003187
      Homo sapiens, putative G-protein coupled receptor, clone MGC:688 IMAGE:3537949, mRNA, complete cds
      gi|13112026|gb|BC003187.1|BC003187[13112026]
    • 4745: BC003142
      Homo sapiens, vesicle-associated soluble NSF attachment protein receptor (v-SNARE; homolog of S. cerevisiae VTI1), clone MGC:3767 IMAGE:2958320, mRNA, complete cds
      gi|13111940|gb|BC003142.1|BC003142[13111940]
    • 4746: BC003110
      Homo sapiens, interleukin 11 receptor, alpha, clone MGC:2146 IMAGE:3502059, mRNA, complete cds
      gi|13111884|gb|BC003110.1|BC003110[13111884]
    • 4747: BC003091
      Homo sapiens, poliovirus receptor-related 2 (herpesvirus entry mediator B), clone MGC:1349 IMAGE:3503222, mRNA, complete cds
      gi|13111848|gb|BC003091.1|BC003091[13111848]
    • 4748: BC000181
      Homo sapiens, putative G protein-coupled receptor, clone MGC:5003 IMAGE:3048193,
      mRNA, complete cds
      gi|13111815|gb|BC000181.2|BC000181[13111815]
    • 4751: BC003005
      Homo sapiens, unactive progesterone receptor, 23 kD, clone MGC:4004 IMAGE:2821965, mRNA, complete cds
      gi|12804292|gb|BC003005.1|BC003005[12804292]
    • 4752: BC002996
      Homo sapiens, cholinergic receptor, nicotinic, alpha polypeptide 3, clone MGC:3862 IMAGE:2822768, mRNA, complete cds
      gi|12804274|gb|BC002996.1|BC002996[12804274]
    • 4753: BC002947
      Homo sapiens, folate receptor 1 (adult), clone MGC:10473 IMAGE:3956659, mRNA, complete cds
      gi|12804178|gb|BC002947.1|BC002947[12804178]
    • 4754: BC002819
      Homo sapiens, putative receptor protein, clone MGC:3676 IMAGE:3636199, mRNA, complete cds
      gi|12803944|gb|BC002819.1|BC002819[12803944]
    • 4755: BC002794
      Homo sapiens, tumor necrosis factor receptor superfamily, member 14 (herpesvirus
      entry mediator), clone MGC:3753 IMAGE:3614650, mRNA, complete cds
      gi|12803894|gb|BC002794.1|BC002794[12803894]
    • 4756: BC002793
      Homo sapiens, interferon (alpha, beta and omega) receptor 2, clone MGC:3873 IMAGE:3626374, mRNA, complete cds
      gi|12803892|gb|BC002793.1|BC002793[12803892]
    • 4757: BC002788
      Homo sapiens, plasminogen activator, urokinase receptor, clone MGC:3905 IMAGE:3617894, mRNA, complete cds
      gi|12803884|gb|BC002788.1|BC002788[12803884]
    • 4758: BC002635
      Homo sapiens, colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage), clone MGC:3848 IMAGE:3606186, mRNA, complete cds
      gi|12803600|gb|BC002635.1|BC002635[12803600]
    • 4759: BC002537
      Homo sapiens, fibroblast growth factor receptor-like 1, clone IMAGE:3140874, mRNA
      gi|12803426|gb|BC002537.1|BC002537[12803426]
    • 4760: BC002464
      Homo sapiens, coagulation factor II (thrombin) receptor, clone MGC:1197 IMAGE:3343051, mRNA, complete cds
      gi|12803296|gb|BC002464.1|BC002464[12803296]
    • 4761: BC002443
      Homo sapiens, putative T1/ST2 receptor binding protein, clone MGC:1270 IMAGE:3346273, mRNA, complete cds
      gi|12803256|gb|BC002443.1|BC002443[12803256]
    • 4762: BC002354
      Homo sapiens, 5-hydroxytryptamine (serotonin) receptor 3A, clone MGC:8469 IMAGE:2821710, mRNA, complete cds
      gi|12803100|gb|BC002354.1|BC002354[12803100]
    • 4763: BC001379
      Homo sapiens, G protein-coupled receptor kinase-interactor 2, clone MGC:760 IMAGE:3051069, mRNA, complete cds
      gi|12655058|gb|BC001379.1|BC001379[12655058]
    • 4764: BC001281
      Homo sapiens, tumor necrosis factor receptor superfamily, member lob, clone MGC:5144 IMAGE:3458466, mRNA, complete cds
      gi|12654874|gb|BC001281.1|BC001281[12654874]
    • 4766: BC001188
      Homo sapiens, transferrin receptor (p90, CD71), clone MGC:3151 IMAGE:3354176, mRNA, complete cds
      gi|12654696|gb|BC001188.1|BC001188[12654696]
    • 4769: BC001110
      Homo sapiens, benzodiazapine receptor (peripheral), clone MGC:1184 IMAGE:2989070, mRNA, complete cds
      gi|12654552|gb|BC001110.1|BC001110[12654552]
    • 4770: BC000740
      Homo sapiens, cholecystokinin B receptor, clone MGC:2199 IMAGE:3504160, mRNA, complete cds
      gi|12653894|gb|BC000740.1|BC000740[12653894]
    • 4772: BC000571
      Homo sapiens, pyrimidinergic receptor P2Y, G-protein coupled, 6, clone MGC:2067
      IMAGE:3162734, mRNA, complete cds
      gi|12653590|gb|BC000571.1|BC000571[12653590]
    • 4773: BC000548
      Homo sapiens, receptor (calcitonin) activity modifying protein 1, clone MGC:1996
      IMAGE:3163522, mRNA, complete cds
      gi|12653550|gb|BC000548.1|BC000548[12653550]
    • 4774: BC000513
      Homo sapiens, cholinergic receptor, nicotinic, alpha polypeptide 3, clone MGC:8545 IMAGE:2822768, mRNA, complete cds
      gi|12653482|gb|BC000513.1|BC000513[12653482]
    • 4776: BC000254
      Homo sapiens, activin A receptor, type IB, clone MGC:2177 IMAGE:3352720, mRNA,
      complete cds
      gi|12652986|gb|BC000254.1|BC000254[12652986]
    • 4780: AF037351
      Homo sapiens macrophage scavenger receptor type III (SR-A) mRNA, complete cds
      gi|3004959|gb|AF037351.1|AF037351[3004959]
    • 4781: BC009277
      Homo sapiens, G protein-coupled receptor kinase 6, clone IMAGE:4053197, mRNA
      gi|14627273|gb1BC009277.1|BC009277[14627273]
    • 4782: AF369786
      Homo sapiens growth hormone secretagogue receptor gene, complete cds, alternatively spliced
      gi|14625865|gb|AF369786.1|AF369786[14625865]
    • 4784: U35877
      Homo sapiens (−) genotype B2 bradykinin receptor gene, exon 1
      gi|1353393|gb|U35877.1|HSU35877[1353393]
    • 4785: U35876
      Homo sapiens (+) genotype B2 bradykinin receptor gene, exon 1
      gi|1353392|gb|U35876.1|HSU35876[1353392]
    • 4786: NM005656
      Homo sapiens transmembrane protease, serine 2 (TMPRSS2), mRNA
      gi|14602458|ref|NM005656.2|[14602458]
    • 4787: NM004167
      Homo sapiens small inducible cytokine subfamily A (Cys-Cys), member 15 (SCYA15),
      transcript variant 2, mRNA
      gi|14602450|ref|NM004167.2|[14602450]
    • 4788: NM032965
      Homo sapiens small inducible cytokine subfamily A (Cys-Cys), member 15 (SCYA15),
      transcript variant 3, mRNA
      gi|14602448|ref|NM032965.1|[14602448]
    • 4789: NM032964
      Homo sapiens small inducible cytokine subfamily A (Cys-Cys), member 15 (SCYA15),
      transcript variant 1, mRNA
      gi|14602446|ref|NM032964.1|[14602446]
    • 4790: AJ312373
      Homo sapiens mRNA for DECTIN-1 receptor, splice variant 2
      gi|14599395|emb|AJ312373.1|HSA312373[14599395]
    • 4791: AJ312372
      Homo sapiens mRNA for DECTIN-1 receptor, splice variant 1
      gi|14599393|emb|AJ312372.1|HSA312372[14599393]
    • 4792: AJ307885
      Homo sapiens mRNA for T-cell receptor beta chain, clone 83
      gi|14595016|emb|AJ307885.1|HSA307885[14595016]
    • 4793: NM001987
      Homo sapiens ets variant gene 6 (TEL oncogene) (ETV6), mRNA
      gi|14589947|ref|NM001987.2|[14589947]
    • 4794: NM020403
      Homo sapiens protocadherin 9 (PCDH9), mRNA
      gi|14589940|ref|NM020403.2|[14589940]
    • 4795: NM022843
      Homo sapiens protocadherin 20 (PCDH20), mRNA
      gi|14589938|ref|NM022843.1|[14589938]
    • 4797: NM020164
      Homo sapiens aspartate beta-hydroxylase (ASPH), transcript variant 5, mRNA
      gi|14589858|ref|NM020164.2|[14589858]
    • 4798: AF361107
      Homo sapiens CRHF2 receptor beta-isoform mRNA, partial sequence, aberrantly spliced
      gi|14586958|gb|AF361107.1|AF361107[14586958]
    • 4799: AF361106
      Homo sapiens CRHF2 receptor beta-isoform mRNA, partial sequence, aberrantly spliced
      gi|14586957|gb|AF361106.1|AF361106[14586957]
    • 4800: AF284768
      Homo sapiens laminin receptor-like protein LAMRL5 mRNA, complete cds
      gi|14583013|gb|AF284768.1|AF284768[14583013]
    • 4801: AF343090
      Homo sapiens HSF-27 protein mRNA, complete cds
      gi|14582809|gb|AF343090.1|AF343090[14582809]
    • 4802: AF286696
      Homo sapiens olfactory receptor sdolf mRNA, complete cds
      gi|14582606|gb|AF286696.1|AF286696[14582606]
    • 4803: AF279673
      Homo sapiens vanilloid receptor-like protein 2 (VRL2) mRNA, complete cds
      gi|14582397|gb|AF279673.1|AF279673[14582397]
    • 4804: AF279611
      Homo sapiens cysteinyl leukotriene receptor type 2 (CYSLT2) gene, complete cds
      gi|14582393|gb|AF2796711.1|AF279611[14582393]
    • 4806: NM005111
      Homo sapiens crystallin, zeta (quinone reductase)-like 1 (CRYZL1), mRNA
      gi|14577924|ref|NM005111.2|[14577924]
    • 4807: NM000592
      Homo sapiens complement component 4B (C4B), mRNA
      gi|14577920|ref|NM000592.3|[14577920]
    • 4809: NM016557
      Homo sapiens orphan seven-transmembrane receptor, chemokine related (VSHK1), mRNA
      gi|7706768|ref|NM016557.1|[7706768]
    • 4810: NM006850
      Homo sapiens interleukin 24 (IL24), mRNA
      gi|5803085|ref|NM006850.1|[5803085]
    • 4811: NM000029
      Homo sapiens angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A
      (alpha-1 antiproteinase, antitrypsin), member 8) (AGT), mRNA
      gi|4557286|ref|NM000029.1|[4557286]
    • 4812: AF385591
      Homo sapiens m5 muscarinic cholinergic receptor (CHRM5) mRNA, complete cds
      gi|14573544|gb|AF385591.1|AF385591[14573544]
    • 4813: AF385590
      Homo sapiens m4 muscarinic cholinergic receptor (CHRM4) mRNA, complete cds
      gi|14573542|gb|AF385590.1|AF385590[14573542]
    • 4814: AF385589
      Homo sapiens m3 muscarinic cholinergic receptor (CHRM3) mRNA, partial cds
      gi|14573540|gb|AF385589.1|AF385589[14573540]
    • 4815: AF385588
      Homo sapiens m2 muscarinic cholinergic receptor (CHRM2) mRNA, complete cds
      gi|14573538|gb|AF385588.1|AF385588[14573538]
    • 4816: AF385587
      Homo sapiens ml muscarinic cholinergic receptor (CHRM1) mRNA, complete cds
      gi|14573536|gb|AF385587.1|AF385587[14573536]
    • 4817: AF385585
      Homo sapiens nicotinic cholinergic receptor alpha 7 (CHRNA7) mRNA, complete cds
      gi|14573533|gb|AF385585.1|AF385585[14573533]
    • 4818: AF385584
      Homo sapiens nicotinic cholinergic receptor alpha 3 (CHRNA3) mRNA, partial cds
      gi|4573531|gb|AF385584.1|AF385584[14573531]
    • 4819: AF361943
      Homo sapiens urocortin III (UCNIII) gene, complete cds
      gi|14571921|gb|AF361943.1|AF361943[14571921]
    • 4825: NM031282
      Homo sapiens immunoglobulin superfamily receptor translocation associated 1 (IRTA1), mRNA
      gi|14550415|ref|NM031282.1|[14550415]
    • 4826: NM031281
      Homo sapiens immunoglobulin superfamily receptor translocation associated 2 (IRTA2), mRNA
      gi|14550413|ref|NM031281.1|[14550413]
    • 4827: NM020404
      Homo sapiens tumor endothelial marker 1 precursor (TEM1), mRNA
      gi|9966884|ref|NM020404.1|[9966884]
    • 4830: AF338733
      Homo sapiens thymic stromal lymphopoietin protein receptor TSLPR mRNA, complete
      cds
      gi|14335439|gb|AF338733.1|AF338733[14335439]
    • 4831: AF338732
      Homo sapiens thymic stromal lymphopoietin protein TSLP mRNA, complete cds
      gi|14335437|gb|AF338732.1|AF338732[14335437]
    • 4832: AJ272324
      Homo sapiens mRNA for PRAM-1 protein
      gi|11558108|emb|AJ272324.1|HSA272324[11558108]
    • 4833: AF281043
      Homo sapiens high mobility group 1 protein (HMG1) gene, promoter and partial cds
      gi|14522873|gb|AF281043.1|AF281043[14522873]
    • 4834: NM024298
      Homo sapiens malignant cell expression-enhanced gene/tumor progression-enhance (LENG4), mRNA
      gi|13236521|ref|NM024298.1|[13236521]
    • 4835: AB051580
      Homo sapiens gene for IgG receptor IIIB, complete cds
      gi|11344590|dbj|AB051580.1|AB051580[11344590]
    • 4836: NM006134
      Homo sapiens chromosome 21 open reading frame 4 (C21orf4), mRNA
      gi|8659558|ref|NM006134.2|[8659558]
    • 4837: NM015927
      Homo sapiens transforming growth factor beta 1 induced transcript 1 (TGFB1I1),
      mRNA
      gi|7706249|ref|NM015927.1|[7706249]
    • 4838: NM000956
      Homo sapiens prostaglandin E receptor 2 (subtype EP2), 53 kD (PTGER2), mRNA
      gi|4506254|ref|NM000956.1|[4506254]
    • 4839: AF019381
      Homo sapiens corticotropin releasing hormone receptor type 2 gamma isoform (CRH2R) mRNA, complete cds
      gi|2738888|gb|AF019381.1|AF019381[2738888]
    • 4840: AB043702
      Homo sapiens FZD5 mRNA for seven-transmembrane receptor Frizzled-5, complete cds
      gi|14495150|dbj|AB043702.1|AB043702[14495150]
    • 4841: AF384819
      Homo sapiens coagulation factor II receptor-like 3 (F2RL3) gene, complete cds
      gi|14488403|gb|AF384819.2|AF384819[14488403]
    • 4842: AF343666
      Homo sapiens translocation associated fusion protein IRTA1/IGA1 (IRTA1/IGHA1) mRNA, complete cds
      gi|13591717|gb|AF343666.1|AF343666[13591717]
    • 4843: AF343665
      Homo sapiens immunoglobulin superfamily receptor translocation associated protein 2d (IRTA2) mRNA, partial cds, alternatively spliced
      gi|13591715|gb|AF343665.1|AF343665[13591715]
    • 4844: AF343664
      Homo sapiens immunoglobulin superfamily receptor translocation associated protein 2c (IRTA2) mRNA, complete cds, alternatively spliced
      gi|13591713|gb|AF343664.1|AF343664[13591713]
    • 4845: AF343663
      Homo sapiens immunoglobulin superfamily receptor translocation associated protein 2b (IRTA2) mRNA, complete cds, alternatively spliced
      gi|13591711|gb|AF343663.1|AF343663[13591711]
    • 4846: AF343662
      Homo sapiens immunoglobulin superfamily receptor translocation associated protein 2a (IRTA2) mRNA, complete cds, alternatively spliced
      gi|13591709|gb|AF343662.1|AF343662[13591709]
    • 4847: AF343661
      Homo sapiens immunoglobulin superfamily receptor translocation associated protein 1a (IRTA1) mRNA, complete cds, alternatively spliced
      gi|13591707|gb|AF343661.1|AF343661[13591707]
    • 4848: AF343660
      Homo sapiens immunoglobulin superfamily receptor translocation associated protein 1b (IRTA1) mRNA, complete cds, alternatively spliced
      gi|13591705|gb|AF343660.1|AF343660[13591705]
    • 4849: AF343659
      Homo sapiens immunoglobulin superfamily receptor translocation associated protein 1c (IRTA1) mRNA, complete cds, alternatively spliced
      gi|13591703|gb|AF343659.1|AF343659[13591703]
    • 4850: AF321237
      Homo sapiens chromosome 11p15.4 clone RPC11-610i20 P2-containing olfactory receptor gene cluster, complete sequence
      gi|12007433|gb|AF321237.1|AF321237[12007433]
    • 4851: NM005567
      Homo sapiens lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP),
      mRNA
      gi|6006016|ref|NM005567.21[6006016]
    • 4852: AF351620
      Homo sapiens lipocalin-1 interacting membrane receptor (LIMR) gene, complete cds
      gi|14485746|gb|AF351620.1|AF351620[14485746]
    • 4853: AF366519
    • 4890: AB063174
      Homo sapiens SLC-1 mRNA for somatostatin receptor-like protein, complete cds
      gi|14475646|dbj|AB063174.1|AB063174[14475646]
    • 4891: AF238470
      Homo sapiens natural killer cell receptor NKG2F gene, partial cds
      gi|11023178|gb|AF238470.1|AF238470[11023178]
    • 4892: AF238469
      Homo sapiens natural killer cell receptor NKG2E gene, partial cds
      gi|11023176|gb|AF238469.1|AF238469[11023176]
    • 4893: AF238468
      Homo sapiens natural killer cell receptor NKG2C gene, partial cds
      gi|11023174|gb|AF238468.1|AF238468[11023174]
    • 4894: AE000662
      Homo sapiens T-cell receptor alpha delta locus from bases 1000498 to 1071650 (section 5 of 5) of the Complete Nucleotide Sequence
      gi|2358068|gb|AE000662.1|HUAE000662[2358068]
    • 4895: AE000661
      Homo sapiens T-cell receptor alpha delta locus from bases 752679 to 1000555 (section 4 of 5) of the Complete Nucleotide Sequence
      gi|2358060|gb|AE000661.1|HUAE000661[2358060]
    • 4896: AE000660
      Homo sapiens T-cell receptor alpha delta locus from bases 501613 to 752736 (section 3 of 5) of the Complete Nucleotide Sequence
      gi|2358042|gb|AE000660.1|HUAE000660[2358042]
    • 4897: AE000659
      Homo sapiens T-cell receptor alpha delta locus from bases 250472 to 501670 (section 2 of 5) of the Complete Nucleotide Sequence
      gi|2358025|gb|AE000659.1|HUAE000659[2358025]
    • 4898: AE000658
      Homo sapiens T-cell receptor alpha delta locus from bases 1 to 250529 (section 1 of 5) of the Complete Nucleotide Sequence
      gi|2358019|gb|AE000658.1|HUAE000658[2358019]
    • 4899: AF364129
      Homo sapiens tandem repeat region 76.3 kb upstream of BMPR1A exon 1
      gi|14423333|gb|AF364129.1|AF364129[14423333]
    • 4900: AF364128
      Homo sapiens tandem repeat region 49.4 kb upstream of BMPR1A exon 1
      gi|14423332|gb|AF364128.1|AF364128[14423332]
    • 4901: AF261083
      Homo sapiens polymeric immunoglobulin receptor (PIGR) gene, partial cds
      gi|8099662|gb|AF261083.1|AF261083[8099662]
    • 4902: AF243129
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 67 and partial cds
      gi|14388671|gb|AF243129.1|F243081S49[14388671]
    • 4903: AF243128
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 66
      gi|14388670 gb|AF243128.1|F243081S48[14388670]
    • 4904: AF243127
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 65
      gi|14388669|gb|AF243127.1|F243081S47[14388669]
    • 4905: AF243126
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 63 and
      gi|14388668|gb|AF243126.1|F243081S46[14388668]
    • 4906: AF243125
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 61 and
      gi|14388667|gb|AF243125.1|F243081S45[14388667]
    • 4907: AF243124
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 60
      gi|14388666|gb|AF243124.1|F243081S44[14388666]
    • 4908: AF243123
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 59
      gi|14388665|gb|AF243123.1|F243081S43[14388665]
    • 4909: AF243122
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 58
      gi|14388664|gb|AF243122.1|F243081S42[14388664]
    • 4910: AF243121
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 57
      gi|14388663|gb|AF243121.1|F243081S41[14388663]
    • 4911: AF243120
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 56
      gi|14388662|gb|AF243120.1|F243081S40[14388662]
    • 4912: AF243119
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 55
      gi|4388661|gb|AF243119.1F243081S39[14388661]
    • 4913: AF243118
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 54
      gi|14388660|gb|AF243118.1F243081S38[14388660]
    • 4914: AF243117
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 52 and
      gi|14388659|gb|AF243117.1|F243081S37[14388659]
    • 4915: AF243116
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 51
      gi|14388658|gb|AF243116.1|F243081S36[14388658]
    • 4916: AF243115
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 49 and
      gi|14388657|gb|AF243115.1|F243081S35[14388657]
    • 4917: AF243114
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 48
      gi|14388656|gb|AF243114.1|F243081S34[14388656]
    • 4918: AF243113
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 47
      gi|14388655|gb|AF243113.1F243081S33[14388655]
    • 4919: AF243112
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 46
      gi|14388654|gb|AF243112.1F243081S32[14388654]
    • 4920: AF243111
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 45
      gi|4388653|gb|AF243111.1F243081S31[14388653]
    • 4921: AF243110
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 44
      gi|14388652|gb|AF243110.1|F243081S30[14388652]
    • 4922: AF243109
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 42 and
      gi|14388651|gb|AF243109.1|F243081S29[14388651]
    • 4923: AF243108
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 41
      gi|14388650|gb|AF243108.1|F243081S28[14388650]
    • 4924: AF243107
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 40
      gi|14388649|gb|AF243107.1F243081S27[14388649]
    • 4925: AF243106
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 39
      gi|4388648|gb|AF243106.1F243081S26[14388648]
    • 4926: AF243105
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 37 and
      gi|14388647|gb|AF243105.1|F243081S25[14388647]
    • 4927: AF243104
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 35 and
      gi|14388646|gb|AF243104.1|F243081S24[14388646]
    • 4928: AF243103
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 34
      gi|14388645|gb|AF243103.1F243081S23[14388645]
    • 4929: AF243102
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 33
      gi|14388644|gb|AF243102.1F243081S22[14388644]
    • 4930: AF243101
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 32
      gi|14388643|gb|AF243101.1F243081S21[14388643]
    • 4931: AF243100
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 31
      gi|14388642|gb|AF243100.1F243081S20[14388642]
    • 4932: AF243099
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 30
      gi|1438864|gb|AF243099.1F243081S19[14388641]
    • 4933: AF243098
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 29
      gi|14388640|gb|AF243098.1F243081S18[14388640]
    • 4934: AF243097
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 28
      gi|14388639|gb|AF243097.1F243081S17[14388639]
    • 4935: AF243096
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 27
      gi|14388638|gb|AF243096.1F243081S16[14388638]
    • 4936: AF243095
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 26
      gi|14388637|gb|AF243095.1|F243081S15[14388637]
    • 4937: AF243094
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 23, 24, and 25
      gi|14388636|gb|AF243094.1|F243081S14[14388636]
    • 4938: AF243093
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 22
      gi|14388635|gb|AF243093.1|F243081S13[14388635]
    • 4939: AF243092
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 20 and
      gi|14388634|gb|AF243092.1|F243081S12[14388634]
    • 4940: AF243091
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 18 and
      gi|4388633|gb|AF243091.1|F243081S11[14388633]
    • 4941: AF243090
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 16 and
      gi|14388632|gb|AF243090.1|F243081S10[14388632]
    • 4942: AF243089
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 15
      gi|14388631|gb|AF243089.1|F243081S09[14388631]
    • 4943: AF243088
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 14
      gi|14388630|gb|AF243088.1|F243081S08[14388630]
    • 4944: AF243087
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 11, 12, and 13
      gi|14388629|gb|AF243087.1|F243081S07[14388629]
    • 4945: AF243086
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 9 and
      gi|14388628|gb|AF243086.1|F243081S06[14388628]
    • 4946: AF243085
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 8
      gi|14388627|gb|AF243085.1|F243081S05[14388627]
    • 4947: AF243084
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 7
      gi|14388626|gb|AF243084.1|F243081S04[14388626]
    • 4948: AF243083
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 5 and 6
      gi|14388625|gb|AF243083.1|F243081S03[14388625]
    • 4949: AF243082
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exon 3 and partial cds
      gi|14388624|gb|AF243082.1|F243081S02[14388624]
    • 4950: AF243081
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) gene, exons 1 and 2
      gi|14388623|gb|AF243081.1|F243081S01[14388623]
    • 4951: AH010855
      Homo sapiens intrinsic factor-vitamin B12 receptor (CUBN) and intrinsic factor-vitamin B12 receptor (CUBN) genes, partial cds
      gi|14388622|gb|AH010855.1|SEG_F243081S[14388622]
    • 4952: AY029596
      Homo sapiens melanin-concentrating hormone 2 receptor mRNA, complete cds
      gi|14388165|gb|AY029596.1|[14388165]
    • 4953: AF233349
      Homo sapiens neuronal phosphoprotein DARPP-32 mRNA, partial cds
      gi|7243754|gb|AF233349.1|AF233349[7243754]
    • 4954: AF208690
      Homo sapiens clone 24 p70 killer cell inhibitory receptor mRNA, partial cds
      gi|6851353|gb|AF208690.1|AF208690[6851353]
    • 4955: AF208689
      Homo sapiens clone 22 p70 killer cell inhibitory receptor mRNA, partial cds
      gi|6851351|gb|AF208689.1|AF208689[6851351]
    • 4956: AF208688
      Homo sapiens clone 3 p70 killer cell inhibitory receptor mRNA, partial cds
      gi|6851349|gb|AF208688.1|AF208688[6851349]
    • 4957: AF208687
      Homo sapiens clone 25 p70 killer cell inhibitory receptor mRNA, partial cds
      gi|6851347|gb|AF208687.1|AF208687[6851347]
    • 4958: AF208686
      Homo sapiens clone 23 p70 killer cell inhibitory receptor mRNA, partial cds
      gi|6851345|gb|AF208686.1|AF208686[6851345]
    • 4959: AF208685
      Homo sapiens clone 21 p70 killer cell inhibitory receptor mRNA, partial cds
      gi|6851343|gb|AF208685.1|AF208685[6851343]
    • 4960: AF208684
      Homo sapiens clone 6 p70 killer cell inhibitory receptor mRNA, partial cds
      gi|6851341|gb|AF208684.1|AF208684[6851341]
    • 4961: AF208683
      Homo sapiens clone 1 p70 killer cell inhibitory receptor mRNA, partial cds
      gi|6851339|gb|AF208683.1|AF208683[6851339]
    • 4962: AB052639
      Homo sapiens mRNA for IL-XR, complete cds
      gi|14349288|dbj|AB052639.1|AB052639[14349288]
    • 4963: AF366364
      Homo sapiens interleukin-1 receptor type 1 (IL1R1) gene, exon 1A, partial sequence
      gi|1434887|gb|AF366364.1|AF366364[14348871]
    • 4967: AF260728
      Homo sapiens lipocalin-interacting protein mRNA, complete cds
      gi|14335227|gb|AF260728.1|AF260728[14335227]
    • 4968: AJ308526
      Homo sapiens partial GRIK3 gene for glutamate receptor 7, exon 18
      gi|14329723|emb|AJ308526.1|HSA308526[14329723]
    • 4969: AJ308525
      Homo sapiens partial GRIK3 gene for glutamate receptor 7, exon 16
      gi|14329720|emb|AJ308525.1|HSA308525[14329720]
    • 4970: AF165124
      Homo sapiens chromosome 5q31.1-q33.1 clone BAC djn082c10 containing GABRG2 gene,
      complete sequence
      gi|5738137|gb|AF165124.1|AF165124[5738137]
    • 4971: AF353733
      Homo sapiens leukocyte immunoglobulin-like receptor A3 (LILRA3) gene, exon 3 and
      partial cds
      gi|4280086|gb|AF353733.1|AF353733[14280086]
    • 4972: AF236083
      Homo sapiens G-protein-coupled receptor 74 (GPR74) mRNA, complete cds
      gi|14279164|gb|AF236083.1|AF236083[14279164]
    • 4973: AF375468
      Homo sapiens endothelial protein C receptor (PROCR) gene, complete cds
      gi|1427871|gb|AF375468.2|AF375468[14278711]
    • 4974: AF374726
      Homo sapiens coagulation factor II receptor-like 2 (F2RL2) gene, complete cds
      gi|14278710|gb|AF374726.2|AF374726[14278710]
    • 4975: AF378542
      Homo sapiens bradykinin receptor B2 (BDKRB2) gene, complete cds
      gi|14278705|gb|AF378542.2|AF378542[14278705]
    • 4976: AB051065
      Homo sapiens hot7t175 mRNA for G protein-coupled receptor, complete cds
      gi|14041797|dbj|AB051065.1|AB051065[14041797]
    • 4977: AF347063
      Homo sapiens G protein-coupled receptor MCH2 mRNA, complete cds
      gi|13604341|gb|AF347063.1|AF347063[13604341]
    • 4978: AJ278250
      Homo sapiens HRH3 gene for histamine H3 receptor, exons 1-3
      gi|14270360|emb|AJ278250.1|HSA278250[14270360]
    • 4979: AF297616
      Homo sapiens natural killer cell receptor 2B4 gene, partial cds
      gi|14268841|gb|AF297616.1|AF297616[14268841]
    • 4980: AJ271068
      Homo sapiens mRNA for transient receptor potential channel 6, variant delta377-431 (TRP6 gene)
      gi|9716912|emb|AJ271068.1|HSA271068[9716912]
    • 4981: AJ271067
      Homo sapiens mRNA for transient receptor potential channel 6, variant delta316-431 (TRP6 gene)
      gi|9716910|emb|AJ271067.1|HSA271067[9716910]
    • 4982: AJ271066
      Homo sapiens mRNA for transient receptor potential channel 6 (TRP6 gene)
      gi|9716908|emb|AJ271066.1|HSA271066[9716908]
    • 4983: X91852
      H. sapiens P2Y4 gene
      gi|1124904|emb|X91852.1|HSP2Y4[1124904]
    • 4984: NM032565
      Homo sapiens emopamil binding related protein, delta8-delta7 sterol isomerase related protein (EBRP), mRNA
      gi|4211872|ref|NM032565.1|[14211872]
    • 4986: AY029539
      Homo sapiens soluble nectin1 gamma mRNA, complete cds
      gi|1419622|gb|AY029539.1|[14196221]
    • 4987: NM006986
      Homo sapiens melanoma antigen, family D, 1 (MAGED1), mRNA
      gi|14195633|ref|NM006986.2|[14195633]
    • 4988: AF351784
      Homo sapiens dopamine receptor interacting protein mRNA, partial cds
      gi|14194056|gb|AF351784.1|AF351784[14194056]
    • 4989: AF336376
      Homo sapiens platelet-derived growth factor D (PDGFD) mRNA, complete cds
      gi|14193795|gb|AF336376.1|AF336376[14193795]
    • 4992: AH010778
      Homo sapiens CHRNA3 gene, partial sequence
      gi|14190789|gb|AH010778.1|SEG_AY027913S[14190789]
    • 4995: AH010779
      Homo sapiens CHRNB4 gene, partial sequence
      gi|14190786|gb|AH010779.1|SEG_AY027915S[14190786]
    • 4996: AF310234
      Homo sapiens sialic acid binding immunoglobulin-like lectin 8 (SIGLEC8) mRNA, complete cds, alternatively spliced
      gi|14164614|gb|AF310234.1|AF310234[14164614]
    • 4997: AF310233
      Homo sapiens sialic acid binding immunoglobulin-like lectin 10 (SIGLEC10) mRNA,
      complete cds
      gi|14164612|gb|AF310233.1|AF310233[14164612]
    • 4998: AB060151
      Homo sapiens slt mRNA for G protein-coupled receptor, complete cds
      gi|14164382|dbj|AB060151.1|AB060151[14164382]
    • 4999: AF239764
      Homo sapiens EGF-like module-containing mucin-like receptor EMR3 mRNA, complete
      cds
      gi|13183148|gb|AF239764.1|AF239764[13183148]
    • 5000: AF199235
      Homo sapiens nicotinic acetylcholine receptor subunit alpha 10 mRNA, complete cds
      gi|11128455|gb|AF199235.2|AF199235[11128455]
    • 5001: AF054176
      Homo sapiens angiotensin/vasopressin receptor AII/AVP mRNA, complete cds
      gi|3341995|gb|AF054176.1|AF054176[3341995]
    • 5002: AF369213
      Homo sapiens fibroblast growth factor receptor 3 IIIc isoform (FGFR3) mRNA, partial cds
      gi|14161391|gb|AF369213.1|AF369213[14161391]
    • 5003: AF369212
      Homo sapiens fibroblast growth factor receptor 3 IIIc isoform (FGFR3) mRNA, partial cds
      gi|14161389|gb|AF369212.1|AF369212[14161389]
    • 5004: AF369211
      Homo sapiens fibroblast growth factor receptor 3 IIIc isoform (FGFR3) mRNA, partial cds
      gi|14161387|gb|AF369211.1|AF369211[14161387]
    • 5005: AF274714
      Homo sapiens oxysterol-binding protein-related protein (ORP1) mRNA, complete cds
      gi|13183326|gb|AF274714.1|AF274714[13183326]
    • 5034: NM005959
      Homo sapiens melatonin receptor 1B (MTNR1B), mRNA
      gi|14141172|ref|NM005959.2|[14141172]
    • 5035: NM005958
      Homo sapiens melatonin receptor 1A (MTNR1A), mRNA
      gi|14141171|ref|NM005958.2|[14141171]
    • 5036: AF366903
      Homo sapiens MER receptor tyrosine kinase gene, exon 1 and partial cds
      gi|14133725|gb|AF366903.1|AF366903[14133725]
    • 5037: NM002226
      Homo sapiens jagged 2 (JAG2), mRNA
      gi|4504800|ref|NM002226.1|[4504800]
    • 5039: NM009585
      Homo sapiens angiotensin receptor 1 (AGTR1), transcript variant 2, mRNA
      gi|14043067|ref|NM009585.2|[14043067]
    • 5040: NM032049
      Homo sapiens angiotensin receptor 1 (AGTR1), transcript variant 5, mRNA
      gi|14043065|ref|NM032049.1|[14043065]
    • 5041: NM031850
      Homo sapiens angiotensin receptor 1 (AGTR1), transcript variant 4, mRNA
      gi|14043063|ref|NM031850.1|[14043063]
    • 5042: NM004835
      Homo sapiens angiotensin receptor 1 (AGTR1), transcript variant 3, mRNA
      gi|14043061|ref|NM004835.2|[14043061]
    • 5043: NM000685
      Homo sapiens angiotensin receptor 1 (AGTR1), transcript variant 1, mRNA
      gi|14043060|ref|NM000685.3|[14043060]
    • 5044: NM003965
      Homo sapiens chemokine (C-C motif) receptor-like 2 (CCRL2), mRNA
      gi|14043058|ref|NM003965.2|[14043058]
    • 5045: AJ298334
      Homo sapiens mRNA for P2Y11 receptor (P2Y11 gene)
      gi|12964589|emb|AJ298334.1|HSA298334[12964589]
    • 5046: NM000323
      Homo sapiens ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) (RET), transcript variant 1, mRNA
      gi|10862704|ref|NM000323.1|[10862704]
    • 5047: NM020975
      Homo sapiens ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) (RET), transcript variant 2, mRNA
      gi|10862702|ref|NM020975.1|[10862702]
    • 5048: NM020630
      Homo sapiens ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) (RET), transcript variant 4, mRNA
      gi|10862700|ref|NM020630.1|[10862700]
    • 5049: NM020629
      Homo sapiens ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) (RET), transcript variant 3, mRNA
      gi|10862698|ref|NM020629.1|[10862698]
    • 5050: NM002342
      Homo sapiens lymphotoxin beta receptor (TNFR superfamily, member 3) (LTBR), mRNA
      gi|4505038|ref|NM002342.1|[4505038]
    • 5051: AY032736
      Homo sapiens alpha-2A adrenergic receptor (ADR2AR) gene, complete cds
      gi|14029162|gb|AY032736.1|[14029162]
    • 5052: AF322014
      Homo sapiens growth hormone receptor gene, partial sequence
      gi|14028657|gb|AF322014.1|AF322014S1[14028657]
    • 5053: AF283321
      Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5) gene, exons 10 through 23 and complete cds
      gi|14028617|gb|AF283321.1|AF283320S2[14028617]
    • 5054: AF283320
      Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5) gene, exons 1 through 9
      gi|14028616|gb|AF283320.1|AF283320S1[14028616]
    • 5055: AH010745
      Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5) gene, complete cds
      gi|14028615|gb|AH010745.1|SEG_AF283320S[14028615]
    • 5056: NM017934
      Homo sapiens pleckstrin homology domain interacting protein (PHIP), mRNA
      gi|8923633|ref|NM017934.1|[8923633]
    • 5057: AF203386
      Homo sapiens beta-2 adrenergic receptor (ADRB2) gene, complete cds
      gi|6636495|gb|AF203386.1|AF203386[6636495]
    • 5058: AF202305
      Homo sapiens beta-2 andrenergic receptor gene, complete cds
      gi|6573152|gb|AF202305.1|AF202305[6573152]
    • 5059: AF169225
      Homo sapiens beta-2-adrenergic receptor gene, complete cds
      gi|5714687|gb|AF169225.1|AF169225[5714687]
    • 5060: AF063657
      Homo sapiens vascular endothelial growth factor receptor (FLT1) mRNA, complete
      cds
      gi|3132830|gb|AF063657.1|AF063657[3132830]
    • 5061: AF022049
      Homo sapiens natural killer cell inhibitory receptor KIR3DL1 variant mRNA, complete cds
      gi|2760898|gb|AF022049.1|AF022049[2760898]
    • 5062: AF022048
      Homo sapiens natural killer cell inhibitory receptor KIR2DL3 variant mRNA, complete cds
      gi|2760896|gb|AF022048.1|AF022048[2760896]
    • 5066: AF361880
      Homo sapiens neurokinin-2 receptor gene, partial cds
      gi|1400294|gb|AF361880.1|AF361880[14010294]
    • 5068: AF209923
      Homo sapiens orphan G-protein coupled receptor (GPRC5D) mRNA, complete cds
      gi|8118039|gb|AF209923.1|AF209923[8118039]
    • 5069: AF207989
      Homo sapiens orphan G-protein coupled receptor (GPRC5C) mRNA, complete cds
      gi|8118031|gb|AF207989.1|AF207989[8118031]
    • 5070: AB018076
      Homo sapiens hedgehog gene, exon 3 and complete cds
      gi|13990993|dbj|AB018076.2|AB010092S3[13990993]
    • 5071: SEG_AB010092S
      Homo sapiens hedgehog gene
      gi|13990992|dbj|SEG_AB010092S[13990992]
    • 5072: NM018980
      Homo sapiens taste receptor, type 2, member 5 (TAS2R5), mRNA
      gi|9507172|ref|NM018980.1|[9507172]
    • 5073: NM016945
      Homo sapiens taste receptor, type 2, member 16 (TAS2R16), mRNA
      gi|8394394|ref|NM016945.1|[8394394]
    • 5074: AB018075
      Homo sapiens hedgehog gene, exon 2
      gi|3702725|dbj|AB018075.1|AB010092S2[3702725]
    • 5075: AB010092
      Homo sapiens hedgehog gene, exon 1
      gi|2810977|dbj|AB010092.1|AB010092S1[2810977]
    • 5076: AF130867
      Homo sapiens smoothened mRNA, partial cds
      gi|4732138|gb|AF130867.1|AF130867[4732138]
    • 5077: AF363791
      Homo sapiens histamine receptor H3S(HRH3) mRNA, complete cds
      gi|13937081|gb|AF363791.1|AF363791[13937081]
    • 5078: AF363452
      Homo sapiens NK cell type I receptor protein 2B4 (CD244) mRNA, partial cds, alternatively spliced
      gi|13937022|gb|AF363452.1|AF363452[13937022]
    • 5079: AY029486
      Homo sapiens G protein gamma subunit 13 mRNA, complete cds
      gi|13936268|gb|AY029486.1|[13936268]
    • 5080: AF224497
      Homo sapiens CC chemokine receptor 3 (CCR3) gene, exon 2 and partial cds
      gi|13924486|gb|AF224497.1|AF224496S2[13924486]
    • 5081: AF224496
      Homo sapiens CC chemokine receptor 3 (CCR3) gene, exon 1
      gi|13924485|gb|AF224496.1|AF224496S1[13924485]
    • 5082: AH010691
      Homo sapiens CC chemokine receptor 3 (CCR3) gene, partial cds
      gi|13924484|gb|AH010691.1|SEG_AF224496S[13924484]
    • 5083: AF224495
      Homo sapiens CC chemokine receptor 3 (CCR3) mRNA, partial cds
      gi|13924481|gb|AF224495.1|AF224495[13924481]
    • 5084: AF251120
      Homo sapiens interleukin-1-related protein short isoform mRNA, complete cds; alternatively spliced
      gi|10185739|gb|AF251120.1|AF251120[10185739]
    • 5085: AF251119
      Homo sapiens interleukin-1-related protein long isoform mRNA, complete cds; alternatively spliced
      gi|10185737|gb|AF251119.1|AF251119[10185737]
    • 5086: AF251118
      Homo sapiens interleukin-1-related protein long isoform a mRNA, complete cds; alternatively spliced
      gi|10185735|gb|AF251118.1|AF251118[10185735]
    • 5087: AF103013
      Homo sapiens JME clone 4 KIR3DL1-like natural killer cell receptor mRNA, complete cds
      gi|3983423|gb|AF103013.1|AF103013[3983423]
    • 5088: AF103012
      Homo sapiens JME clone 3 KIR3DL1-like natural killer cell receptor mRNA, complete cds
      gi|3983421|gb|AF103012.1|AF103012[3983421]
    • 5089: AF103011
      Homo sapiens JME clone 2 KIR3DL1-like natural killer cell receptor mRNA, complete cds
      gi|3983419|gb|AF103011.1|AF103011[3983419]
    • 5090: AF103010
      Homo sapiens JME clone 1 KIR3DL1-like natural killer cell receptor mRNA, complete cds
      gi|3983417|gb|AF103010.1|AF103010[3983417]
    • 5091: AF353183
      Homo sapiens discoidin domain receptor DDR1e (DDR1) mRNA, partial cds, alternatively spliced
      gi|13898644|gb|AF353183.1|AF353183[13898644]
    • 5092: AF353182
      Homo sapiens discoidin domain receptor DDR1d (DDR1) mRNA, partial cds, alternatively spliced
      gi|13898642|gb|AF353182.1|AF353182[13898642]
    • 5096: AF014112
      Homo sapiens phenol UDP-glucuronosyltransferase (UGT1A6) gene, partial cds
      gi|2645490|gb|AF014112.1|AF014112[2645490]
    • 5097: AJ293654
      Homo sapiens partial IL4RA gene for interleukin-4 receptor alfa chain, exon 11,
      ARSPRV allele
      gi|12054061|emb|AJ293654.1|HSA293654[12054061]
    • 5098: AJ293653
      Homo sapiens partial IL4RA gene for interleukin-4 receptor alfa chain, exon 11,
      ACSPRV allele
      gi|12054059|emb|AJ293653.1|HSA293653[12054059]
    • 5099: AJ293652
      Homo sapiens partial IL4RA gene for interleukin-4 receptor alfa chain, exon 11,
      ACSSRI allele
      gi|12054057|emb|AJ293652.1|HSA293652[12054057]
    • 5100: AJ293651
      Homo sapiens partial IL4RA gene for interleukin-4 receptor alfa chain, exon 11,
      ECLPRV allele
      gi|12054055|emb|AJ293651.1|HSA293651[12054055]
    • 5101: AJ293650
      Homo sapiens partial IL4RA gene for interleukin-4 receptor alfa chain, exon 11,
      ECSPRV allele
      gi|12054053|emb|AJ293650.1|HSA293650[12054053]
    • 5102: AJ293649
      Homo sapiens partial IL4RA gene for interleukin-4 receptor alfa chain, exon 11,
      ECSSRV allele
      gi|12054051|emb|AJ293649.1|HSA293649[12054051]
    • 5103: AJ293648
      Homo sapiens partial IL4RA gene for interleukin-4 receptor alfa chain, exon 11,
      ECSPQV allele
      gi|12054049|emb|AJ293648.1|HSA293648[12054049]
    • 5104: AJ293647
      Homo sapiens partial IL4RA gene for interleukin-4 receptor alfa chain, exon 11,
      ECSSQV allele
      gi|12054047|emb|AJ293647.1|HSA293647[12054047]
    • 5105: AF329449
      Homo sapiens histamine receptor H4 mRNA, complete cds
      gi|13876643|gb|AF329449.1|AF329449[13876643]
    • 5106: AF276893
      Homo sapiens p21-activated protein kinase 6 (PAK6) mRNA, complete cds
      gi|9082305|gb|AF276893.1|AF276893[9082305]
    • 5107: AY029324
      Homo sapiens mRNA sequence
      gi|13752242|gb|AY029324.1|[13752242]
    • 5108: AF307337
      Homo sapiens ALPP, ALPPL2, ALPI, XCE, CHRND, and CHRNG genes, complete sequence
      gi|10732831|gb|AF307337.1|AF307337[10732831]
    • 5109: Z75190
      H. sapiens mRNA for apolipoprotein E receptor 2
      gi|1834533|emb|Z75190.1|HSZ75190[1834533]
    • 5110: NM004523
      Homo sapiens kinesin-like 1 (KNSL1), mRNA
      gi|13699823|ref|NM004523.2|[13699823]
    • 5111: NM006646
      Homo sapiens WAS protein family, member 3 (WASF3), mRNA
      gi|13699802|ref|NM006646.2|[13699802]
    • 5112: NM030667
      Homo sapiens protein tyrosine phosphatase, receptor type, O (PTPRO), transcript
      variant 1, mRNA
      gi|13677213|ref|NM030667.1|[13677213]
    • 5113: NM002848
      Homo sapiens protein tyrosine phosphatase, receptor type, O (PTPRO), transcript
      variant 2, mRNA
      gi|13677212|ref|NM002848.2|[13677212]
    • 5114: NM006990
      Homo sapiens WAS protein family, member 2 (WASF2), mRNA
      gi|11386182|ref|NM006990.1|[11386182]
    • 5115: AF250309
      Homo sapiens putative cytokine receptor CRL4 precusor mRNA, complete cds
      gi|13649476|gb|AF250309.1|AF250309[13649476]
    • 5116: AY029180
      Homo sapiens soluble urokinase plasminogen activator receptor precursor (SUPAR)
      mRNA, complete cds
      gi|13641308|gb|AY029180.1|[13641308]
    • 5117: AF346711
      Homo sapiens G-protein couple receptor (GPR48) gene, exons 3 through 18, and complete cds
      gi|13569576|gb|AF346711.1|AF346709S3[13569576]
    • 5118: AF346710
      Homo sapiens G-protein couple receptor (GPR48) gene, exon 2
      gi|13569575|gb|AF346710.1|AF346709S2[13569575]
    • 5119: AF346709
      Homo sapiens G-protein couple receptor (GPR48) gene, exon 1
      gi|13569574|gb|AF346709.1|AF346709S1[13569574]
    • 5120: AH010608
      Homo sapiens G-protein couple receptor (GPR48) gene, complete cds
      gi|13569573|gb|AH010608.1|SEG_AF346709S[13569573]
    • 5121: AF251059
      Homo sapiens FGF receptor 4b mRNA, complete cds
      gi|13625179|gb|AF251059.1|AF251059[13625179]
    • 5122: AF251055
      Homo sapiens 5-HT receptor mRNA, complete cds
      gi|1362517|gb|AF251055.1|AF251055[13625171]
    • 5123: NM030905
      Homo sapiens olfactory receptor, family 2, subfamily J, member 2 (OR2J2), mRNA
      gi|13624330|ref|NM030905.1|[13624330]
    • 5124: NM012377
      Homo sapiens olfactory receptor, family 7, subfamily C, member 2 (OR7C2), mRNA
      gi|13624324|ref|NM012377.1|[13624324]
    • 5125: AB043703
      Homo sapiens FZD8 mRNA for seven-transmembrane receptor Frizzled-8, complete cds
      gi|13623798|dbj|AB043703.1|AB043703[13623798]
    • 5126: AB051851
      Homo sapiens DR3 gene for death receptor 3, complete cds, mutant DR3 sequnce
      gi|13537362|dbj|AB051851.1|AB051851[13537362]
    • 5127: AB051850
      Homo sapiens DR3 gene for death receptor 3, complete cds
      gi|13537360|dbj|AB051850.1|AB051850[13537360]
    • 5128: AF349939
      Homo sapiens prolactin receptor isoform delta S1 precursor, mRNA, complete cds
      gi|13605397|gb|AF349939.1|AF349939[13605397]
    • 5130: AF346629
      Homo sapiens channel-kinase 1 (CHAK1) mRNA, complete cds
      gi|13562152|gb|AP346629.2|AF346629[13562152]
    • 5131: NM012373
      Homo sapiens olfactory receptor, family 3, subfamily A, member 3 (OR3A3), mRNA
      gi|13562103|ref|NM012373.1|[13562103]
    • 5132: AF056979
      Homo sapiens clone YAN1 interferon-gamma receptor mRNA, complete cds
      gi|13562048|gb|AF056979.1|AF056979[13562048]
    • 5133: NM017506
      Homo sapiens olfactory receptor family 7, subfamily C, member 1 (OR7C1), mRNA
      gi|9506798|ref|NM017506.1|[9506798]
    • 5134: AF222689
      Homo sapiens protein arginine N-methyltransferase 1 (HRMT1L2) gene, complete cds, alternatively spliced
      gi|7453574|gb|AF222689.1|AF222689[7453574]
    • 5135: NM005137
      Homo sapiens DiGeorge syndrome critical region gene 2 (DGCR2), mRNA
      gi|4826693|ref|NM005137.1|[4826693]
    • 5136: AC002533
      Homo sapiens clone SCb-24C13 from 7q31.3, complete sequence
      gi|2388587|gb|AC002533.1|AC002533[2388587]
    • 5139: AF263617
      Homo sapiens killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) mRNA, KIR3DL2*00901 allele, complete cds
      gi|13560454|gb|AF263617.1|AF263617[13560454]
    • 5140: AF262974
      Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL1*00801 allele, complete cds
      gi|13560452|gb|AF262974.1|AF262974[13560452]
    • 5141: AF262973
      Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL1*00701 allele, complete cds
      gi|13560450|gb|AF262973.1|AF262973[13560450]
    • 5142: AF262972
      Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL1*00601 allele, partial cds
      gi|13560448|gb|AF262972.1|AF262972[13560448]
    • 5143: AF262971
      Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL1*00501 allele, partial cds
      gi|13560446|gb|AF262971.1|AF262971[13560446]
    • 5144: AF262970
      Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL1*00402 allele, partial cds
      gi|13560444|gb|AF262970.1|AF262970[13560444]
    • 5145: AF262969
      Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL1*00401 allele, partial cds
      gi|13560442|gb|AF262969.1|AF262969[13560442]
    • 5146: AF262968
      Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL1*00102 allele, partial cds
      gi|13560440|gb|AF262968.1|AF262968[13560440]
    • 5147: AF262967
      Homo sapiens killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) mRNA, KIR3DL2*00801 allele, complete cds
      gi|13560438|gb|AF262967.1|AF262967[13560438]
    • 5148: AF262966
      Homo sapiens killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) mRNA, KIR3DL2*00601 allele, partial cds
      gi|13560436|gb|AF262966.1|AF262966[13560436]
    • 5149: AF262965
      Homo sapiens killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) mRNA, KIR3DL2*00701 allele, partial cds
      gi|13560434|gb|AF262965.1|AF262965[13560434]
    • 5150: AF348491
      Homo sapiens chemokine receptor CXCR4 mRNA, complete cds
      gi|13549089|gb|AF348491.1|AF348491[13549089]
    • 5151: AF295368
      Homo sapiens G-protein coupled receptor GPR86 (GPR86) mRNA, complete cds
      gi|12711484|gb|AF295368.1|AF295368[12711484]
    • 5152: AF237763
      Homo sapiens orphan G protein-coupled receptor 87 (GPR87) mRNA, complete cds
      gi|12711472|gb|AF237763.1|AF237763[12711472]
    • 5153: AF237762
      Homo sapiens orphan G protein-coupled receptor 84 (GPR84) mRNA, complete cds
      gi|12711470|gb|AF237762.1|AF237762[12711470]
    • 5154: NM004248
      Homo sapiens G protein-coupled receptor 10 (GPR10), mRNA
      gi|4758473|ref|NM004248.1|[4758473]
    • 5155: AC000099
      Homo sapiens chromosome 7 map 7q31.3 cosmid g0771a003, complete sequence
      gi|1764159|emb|AC99.1|HSAC000099[1764159]
    • 5156: NM030784
      Homo sapiens brain expressed G-protein-coupled receptor PSP24 beta (PSP24B), mRNA
      gi|13540556|ref|NM030784.1|[13540556]
    • 5157: NM030774
      Homo sapiens prostate specific G-protein coupled receptor (PSGR), mRNA
      gi|13540538|ref|NM030774.1|[13540538]
    • 5158: NM030764
      Homo sapiens SH2 domain-containing phosphatase anchor protein 1 (SPAP1), mRNA
      gi|13540524|ref|NM030764.1)[13540524]
    • 5160: AJ249921
      Homo sapiens intergenic region between apoE and apoCI genes
      gi|6006507|emb|AJ249921.1|HSA249921[6006507]
    • 5161: AF050737
      Homo sapiens dopamine D2 receptor (DRD2) gene, complete cds
      gi|382049|gb|AF050737.1|AF050737[3820491]
    • 5162: NM004987
      Homo sapiens LIM and senescent cell antigen-like domains 1 (LIMS1), mRNA
      gi|13518025|ref|NM004987.2|[13518025]
    • 5163: AF348078
      Homo sapiens G-protein coupled receptor 91 (GPR91) mRNA, complete cds
      gi|13517982|gb|AF348078.1|AF348078[13517982]
    • 5164: AJ276125
      Homo sapiens mRNA for inhibitory NK receptor (kir3d gene)
      gi|13516222|emb|AJ276125.1|HSA276125[13516222]
    • 5165: AF246999
      Homo sapiens TRADEbeta mRNA, complete cds
      gi|13506909|gb|AF246999.1|AF246999[13506909]
    • 5166: AF246998
      Homo sapiens TRADEalpha mRNA, complete cds
      gi|13506907|gb|AF246998.1|AF246998[13506907]
    • 5167: AF263450
      Homo sapiens dopamine D3 receptor (DRD3) gene, exon 2 and partial cds
      gi|13506728|gb|AF263450.1|AF148807S2[13506728]
    • 5168: AF148807
      Homo sapiens dopamine D3 receptor (DRD3) gene, exon 1
      gi|13506727|gb|AF148807.1|AF148807S1[13506727]
    • 5169: AH010591
      Homo sapiens dopamine D3 receptor (DRD3) gene, partial cds
      gi|13506726|gb|AH010591.1|SEG_AF148807S[13506726]
    • 5170: Y18388
      Homo sapiens CD163 gene, exon 1 and joined CDS
      gi|5107944|emb|Y18388.1|HSA118388[5107944]
    • 5171: NM002183
      Homo sapiens interleukin 3 receptor, alpha (low affinity) (IL3RA), mRNA
      gi|13324709|ref|NM002183.1|[13324709]
    • 5172: AF142570
      Homo sapiens cytokine receptor CRL2 precusor (CRL2) mRNA, complete cds
      gi|11055018|gb|AF142570.1|AF142570[11055018]
    • 5173: NM006140
      Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (CSF2RA), mRNA
      gi|5453626|ref|NM006140.1|[5453626]
    • 5174: NM002186
      Homo sapiens interleukin 9 receptor (IL9R), mRNA
      gi|4504684|ref|NM002186.1|[4504684]
    • 5175: AF296673
      Homo sapiens toll-like receptor 10 mRNA, complete cds
      gi|13447752|gb|AF296673.1|AF296673[13447752]
    • 5176: AF284095
      Homo sapiens alpha-2A adrenergic receptor mRNA, complete cds
      gi|13447750|gb|AF284095.1|AF284095[13447750]
    • 5177: AF279689
      Homo sapiens fibroblast growth factor receptor 5 (FGFR5) mRNA, complete cds
      gi|13447748|gb|AF279689.1|AF279689[13447748]
    • 5178: NM000861
      Homo sapiens histamine receptor H1 (HRH1), mRNA
      gi|13435403|ref|NM000861.2|[13435403]
    • 5179: NM001514
      Homo sapiens general transcription factor IIB (GTF2B), mRNA
      gi|13435384|ref|NM001514.2|[13435384]
    • 5180: NM022845
      Homo sapiens core-binding factor, beta subunit (CBFB), transcript variant 1, mRNA
      gi|13124880|ref|NM022845.1|[13124880]
    • 5181: AF213460
      Homo sapiens ephrin receptor EPHA3 secreted form (EPHA3) mRNA, complete cds
      gi|12003436|gb|AF213460.1|AF213460[12003436]
    • 5182: AF213459
      Homo sapiens ephrin receptor EPHA3 complete form (EPHA3) mRNA, complete cds
      gi|12003434|gb|AF213459.1|AF213459[12003434]
    • 5183: NM019599
      Homo sapiens taste receptor, type 2, member 1 (TAS2R1), mRNA
      gi|9625042|ref|NM019599.1|[9625042]
    • 5184: NM017579
      Homo sapiens deleted in malignant brain tumors 1 (DMBT1), transcript variant 3,
      mRNA
      gi|8923739|ref|NM017579.1|[8923739]
    • 5185: AJ306481
      Homo sapiens partial CHRNA5 gene for neuronal nicotinic acetylcholine receptor
      alpha-5 subunit, exon 1 and joined CDS
      gi|13400975|emb|AJ306481.1|HSA306481[13400975]
    • 5186: AJ306454
      Homo sapiens partial CHRNB4 gene for neuronal nicotinic acetylcholine receptor
      beta-4 subunit, exon 1 and joined CDS
      gi|13400963|emb|AJ306454.1|HSA306454[13400963]
    • 5187: NM024317
      Homo sapiens immunoglobulin-like transcript 10 (ILT10), mRNA
      gi|13399319|ref|NM024317.1|[13399319]
    • 5188: NM020070
      Homo sapiens immunoglobulin lambda-like polypeptide 1 (IGLL1), mRNA
      gi|13399297|ref|NM020070.1|[13399297]
    • 5189: NM002383
      Homo sapiens MYC-associated zinc finger protein (purine-binding transcription factor) (MAZ), mRNA
      gi|13399295|ref|NM002383.1|[13399295]
    • 5190: AJ306486
      Homo sapiens partial CHRNA5 gene for neuronal nicotinic acetylcholine receptor
      alpha-5 subunit, exon 6
      gi|13399189|emb|AJ306486.1|HSA306486[13399189]
    • 5191: AJ306485
      Homo sapiens partial CHRNA5 gene for neuronal nicotinic acetylcholine receptor
      alpha-5 subunit, exon 5
      gi|13399188|emb|AJ306485.1|HSA306485[13399188]
    • 5192: AJ306484
      Homo sapiens partial CHRNA5 gene for neuronal nicotinic acetylcholine receptor
      alpha-5 subunit, exon 4
      gi|13399187|emb|AJ306484.1|HSA306484[13399187]
    • 5193: AJ306483
      Homo sapiens partial CHRNA5 gene for neuronal nicotinic acetylcholine receptor
      alpha-5 subunit, exon 3
      gi|13399186|emb|AJ306483.1|HSA306483[13399186]
    • 5194: AJ306482
      Homo sapiens partial CHRNA5 gene for neuronal nicotinic acetylcholine receptor
      alpha-5 subunit, exon 2
      gi|13399185|emb|AJ306482.1|HSA306482[13399185]
    • 5195: AJ306459
      Homo sapiens partial CHRNB4 gene for neuronal nicotinic acetylcholine receptor
      beta-4 subunit, exon 6
      gi|13399184|emb|AJ306459.1|HSA306459[13399184]
    • 5196: AJ306458
      Homo sapiens partial CHRNB4 gene for neuronal nicotinic acetylcholine receptor
      beta-4 subunit, exon 5
      gi|13399183|emb|AJ306458.1|HSA306458[13399183]
    • 5197: AJ306457
      Homo sapiens partial CHRNB4 gene for neuronal nicotinic acetylcholine receptor
      beta-4 subunit, exon 4
      gi|13399182|emb|AJ306457.1|HSA306457[13399182]
    • 5198: AJ306456
      Homo sapiens partial CHRNB4 gene for neuronal nicotinic acetylcholine receptor
      beta-4 subunit, exon 3
      gi|13399181|emb|AJ306456.1|HSA306456[13399181]
    • 5199: AJ306455
      Homo sapiens partial CHRNB4 gene for neuronal nicotinic acetylcholine receptor
      beta-4 subunit, exon 2
      gi|13399180|emb|AJ306455.1|HSA306455[13399180]
    • 5200: AJ291675
      Homo sapiens mRNA for putative GDNF family receptor alpha 4, secreted isoform c
      (GFRA4 gene)
      gi|12038960|emb|AJ291675.1|HSA291675[12038960]
    • 5201: AJ291674
      Homo sapiens mRNA for putative GDNF family receptor alpha 4, GPI anchored isoform b (GFRA4 gene)
      gi|12038958|emb|AJ291674.1|HSA291674[12038958]
    • 5202: AJ291673
      Homo sapiens mRNA for GDNF family receptor alpha 4, GPI anchored isoform (GFRA4 gene)
      gi|12038956|emb|AJ291673.1|HSA291673[12038956]
    • 5203: AF245704
      Homo sapiens toll-like receptor 9 (TLR9) mRNA, complete cds
      gi|8575528|gb|AF245704.1|AF245704[8575528]
    • 5204: AF245703
      Homo sapiens toll-like receptor 8 (TLR8) mRNA, complete cds
      gi|8575526|gb|AF245703.1|AF245703[8575526]
    • 5205: AF245702
      Homo sapiens toll-like receptor 7 (TLR7) mRNA, complete cds
      gi|8575524|gb|AF245702.1|AF245702[8575524]
    • 5206: NM016944
      Homo sapiens taste receptor, type 2, member 4 (TAS2R4), mRNA
      gi|8394401|ref|NM016944.1|[8394401]
    • 5207: NM016943
      Homo sapiens taste receptor, type 2, member 3 (TAS2R3), mRNA
      gi|8394397|ref|NM016943.1|[8394397]
    • 5209: AF307776
      Homo sapiens beta-1 adrenergic receptor gene, 5′ UTR and partial cds
      gi|11837864|gb|AF307776.1|AF307776[11837864]
    • 5210: AB026043
      Homo sapiens mRNA for MS4A7, complete cds
      gi|11559249|dbj|AB026043.1|AB026043[11559249]
    • 5211: AB013104
      Homo sapiens mRNA for MS4A6, complete cds
      gi|11559215|dbj|AB013104.1|AB013104[11559215]
    • 5212: AB013103
      Homo sapiens mRNA for MS4A5, complete cds
      gi|11559213|dbj|AB013103.1|AB013103[11559213]
    • 5213: AB013102
      Homo sapiens mRNA for MS4A4, complete cds
      gi|11559211|dbj|AB013102.1|AB013102[11559211]
    • 5215: NM003789
      Homo sapiens TNFRSF1A-associated via death domain (TRADD), mRNA
      gi|13378136|ref|NM003789.1|[13378136]
    • 5216: NM025218
      Homo sapiens UL16-binding protein 1 (ULBP1), mRNA
      gi|13376825|ref|NM025218.1|[13376825]
    • 5217: NM025217
      Homo sapiens UL16-binding protein 2 (ULBP2), mRNA
      gi|13376823|ref|NM025217.1|[13376823]
    • 5218: NM024518
      Homo sapiens UL16-binding protein 3 (ULBP3), mRNA
      gi|13375655|ref|NM024518.1|[13375655]
    • 5220: AB052103
      Homo sapiens SRCL mRNA for scavenger receptor with C-type lectin type II, complete cds
      gi|13365552|dbj|AB052103.1|AB052103[13365552]
    • 5221: AB038518
      Homo sapiens SRCL mRNA for scavenger receptor with C-type lectin type I, complete cds
      gi|13365514|dbj|AB038518.1|AB038518[13365514]
    • 5222: NM021708
      Homo sapiens leukocyte-associated Ig-like receptor 1 (LAIR1), transcript variant
      d, mRNA
      gi|11231178|ref|NM021708.1|[11231178]
    • 5223: NM021706
      Homo sapiens leukocyte-associated Ig-like receptor 1 (LAIR1), transcript variant
      b, mRNA
      gi|11231176|ref|NM021706.1|[11231176]
    • 5224: NM002287
      Homo sapiens leukocyte-associated Ig-like receptor 1 (LAIR1), transcript variant
      a, mRNA
      gi|11231175|ref|NM002287.2|[11231175]
    • 5225: AB038237
      Homo sapiens mRNA for G protein-coupled receptor C5L2, complete cds
      gi|7707800|dbj|AB038237.1|AB038237[7707800]
    • 5226: S82756
      Homo sapiens T cell receptor (Vbeta8.2-N1DbetaN2-Jbeta1.6) mRNA, partial cds
      gi|1835847|gb|S82756.1|S82756[1835847]
    • 5227: S82754
      Homo sapiens T cell receptor mRNA, partial cds
      gi|1835843|gb|S82754.1|S82754[1835843]
    • 5233: NM024318
      Homo sapiens immunoglobulin-like transcript 8 (ILT8), mRNA
      gi|13324689|ref|NM024318.1|[13324689]
    • 5234: AF178982
      Homo sapiens putative G protein-coupled receptor GPCR1 precursor, mRNA, complete
      cds
      gi|13324450|gb|AF178982.1|AF178982[13324450]
    • 5236: NM021956
      Homo sapiens glutamate receptor, ionotropic, kainate 2 (GRIK2), mRNA
      gi|11386136|ref|NM021956.1|[11386136]
    • 5237: NM018724
      Homo sapiens interleukin 20 (IL20), mRNA
      gi|11036633|ref|NM018724.1|[11036633]
    • 5238: AJ295846
      Homo sapiens mRNA for endosialin protein
      gi|13277300|emb|AJ295846.1|HSA295846[13277300]
    • 5242: AF310249
      Homo sapiens peroxisome proliferator activated receptor gamma 2 gene, upstream
      sequence
      gi|13274397|gb|AF310249.1|AF310249[13274397]
    • 5243: AF321815
      Homo sapiens G-protein coupled receptor SP1999 mRNA, complete cds
      gi|12656597|gb|AF321815.1|AF321815[12656597]
    • 5244: AL136818
      Homo sapiens mRNA; cDNA DKFZp434F1726 (from clone DKFZp434F1726)
      gi|12053146|emb|AL136818.1|HSM801786[12053146]
    • 5245: AF285440
      Homo sapiens clone KIR2D54v1 killer-cell Ig-like receptor mRNA, complete cds
      gi|11385699|gb|AF285440.1|AF285440[11385699]
    • 5246: AF285439
      Homo sapiens clone KIR2D52v2 killer-cell Ig-like receptor mRNA, complete cds
      gi|11385697|gb|AF285439.1|AF285439[11385697]
    • 5247: AF285438
      Homo sapiens clone KIR2D52v1 killer-cell Ig-like receptor mRNA, partial cds
      gi|11385695|gb|AF285438.1|AF285438[11385695]
    • 5248: AF285437
      Homo sapiens clone KIR2DS1v2 killer-cell Ig-like receptor mRNA, partial cds
      gi|11385693|gb|AF285437.1|AF285437[11385693]
    • 5249: AF285436
      Homo sapiens clone KIR2DL4v4 killer-cell Ig-like receptor mRNA, complete cds
      gi|11385691|gb|AF285436.1|AF285436[11385691]
    • 5250: AF285435
      Homo sapiens clone KIR2DL3v2 killer-cell Ig-like receptor mRNA, partial cds
      gi|11385689|gb|AF285435.1|AF285435[11385689]
    • 5251: AF285434
      Homo sapiens clone KIR2DL2v2 killer-cell Ig-like receptor mRNA, partial cds
      gi|11385687|gb|AF285434.1|AF285434[11385687]
    • 5252: AF285433
      Homo sapiens clone KIR2DL2v1 killer-cell Ig-like receptor mRNA, partial cds
      gi|11385685|gb|AF285433.1|AF285433[11385685]
    • 5253: AF285432
      Homo sapiens clone KIR2DL1v3 killer-cell Ig-like receptor mRNA, partial cds
      gi|11385683|gb|AF285432.1|AF285432[11385683]
    • 5254: AF285431
      Homo sapiens clone KIR2DL1v2 killer-cell Ig-like receptor mRNA, complete cds
      gi|11385681|gb|AF285431.1|AF285431[11385681]
    • 5255: AJ245872
      Homo sapiens mRNA for putative truncated metabotropic glutamatereceptor 6 form
      b, partial (tr-mGluR6 b)
      gi|6688173|emb|AJ245872.1|HSA245872[6688173]
    • 5256: AJ245871
      Homo sapiens mRNA for putative truncated metabotropic glutamatereceptor 6 form
      a, partial (tr-mGluR6 a)
      gi|6688171|emb|AJ245871.1|HSA245871[6688171]
    • 5258: AL050262
      Homo sapiens mRNA; cDNA DKFZp56410682 (from clone DKFZp56410682); complete cds
      gi|4886482|emb|AL050262.1|HSM800268[4886482]
    • 5259: AF308820
      Homo sapiens adrenocorticotropin receptor gene, upstream sequence
      gi|13272368|gb|AF308820.1|AF308820[13272368]
    • 5260: NM014432
      Homo sapiens interleukin 20 receptor, alpha (IL20RA), mRNA
      gi|7657690|ref|NM014432.1|[7657690]
    • 5261: NM004967
      Homo sapiens integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein
      II) (IBSP), mRNA
      gi|13259536|ref|NM004967.2|[13259536]
    • 5270: AF348323
      Homo sapiens nociceptin receptor (ORL1) mRNA, complete cds
      gi|13022242|gb|AF348323.1|AF348323[13022242]
    • 5272: S79217
      Homo sapiens Ca(2+)-sensing receptor mRNA, partial cds
      gi|1050985|gb|S79217.1|S79217[1050985]
    • 5273: S78723
      Homo sapiens serotonin 5-HT2A receptor (5-HT2A R) gene, partial cds
      gi|1042173|gb|S78723.1|S78723[1042173]
    • 5274: S78505
      Homo sapiens prolactin receptor mRNA, partial cds
      gi|999114|gb|S78505.1S78505[999114]
    • 5277: S77555
      Homo sapiens corticotropin receptor/ACTH receptor gene, partial cds
      gi|957294|gb|S77555.1|S77555[957294]
    • 5278: NM024012
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 5A (HTR5A), mRNA
      gi|13236496|ref|NM024012.1|[13236496]
    • 5279: NM021904
      Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript
      variant 3, mRNA
      gi|11497613|ref|NM021904.1|[11497613]
    • 5280: NM021903
      Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript
      variant 2, mRNA
      gi|11497611|ref|NM021903.1|[11497611]
    • 5281: NM001470
      Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript
      variant 1, mRNA
      gi|10835014|ref|NM001470.1|[10835014]
    • 5282: NM007329
      Homo sapiens deleted in malignant brain tumors 1 (DMBT1), transcript variant 2,
      mRNA
      gi|6633800|ref|NM007329.1|[6633800]
    • 5283: S71404
      Homo sapiens interleukin-9 receptor mRNA, partial cds
      gi|551356|gb|S71404.1|S71404[551356]
    • 5356: NM023031
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      13, mRNA
      gi|13186272|ref|NM023031.1|[13186272]
    • 5357: NM023030
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      12, mRNA
      gi|13186270|ref|NM023030.1|[13186270]
    • 5358: NM023028
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      10, mRNA
      gi|13186268|ref|NM023028.1|[13186268]
    • 5359: NM022976
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      9, mRNA
      gi|13186266|ref|NM022976.1|[13186266]
    • 5360: NM022975
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      8, mRNA
      gi|13186264|ref|NM022975.1|[13186264]
    • 5361: NM022974
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      7, mRNA
      gi|13186262|ref|NM022974.1|[13186262]
    • 5362: NM022973
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      6, mRNA
      gi|13186260|ref|NM022973.1|[13186260]
    • 5363: NM022972
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      5, mRNA
      gi|13186258|ref|NM022972.1|[13186258]
    • 5364: NM022971
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      4, mRNA
      gi|13186256|ref|NM022971.1|[13186256]
    • 5365: NM022970
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      3, mRNA
      gi|13186254|ref|NM022970.1|[13186254]
    • 5366: NM022969
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      2, mRNA
      gi|13186252|ref|NM022969.1|[13186252]
    • 5367: NM023029
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      11, mRNA
      gi|13186242|ref|NM023029.1|[13186242]
    • 5368: NM000141
      Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2), transcript variant
      1, mRNA
      gi|13186239|ref|NM000141.2|[13186239]
    • 5369: AF312678
      Homo sapiens FGF homologous factor receptor (FHFR) mRNA, complete cds
      gi|13183617|gb|AF312678.1|AF312678[13183617]
    • 5370: AF243385
      Homo sapiens beta-2 syntrophin mRNA, complete cds, alternatively spliced
      gi|13183299|gb|AF243385.1|AF243385[13183299]
    • 5371: M97191
      Homo sapiens Sp3 protein mRNA, partial cds
      gi|13162672|gb|M97191.2|HUMSP3A[13162672]
    • 5474: NM024075
      Homo sapiens LENG5 protein (LENG5), mRNA
      gi|13129061|ref|NM024075.1|[13129061]
    • 5475: AF304379
      Homo sapiens ULBP3 protein mRNA, complete cds
      gi|13128926|gb|AF304379.1|AF304379[13128926]
    • 5476: AF304378
      Homo sapiens ULBP2 protein mRNA, complete cds
      gi|13128924|gb|AF304378.1|AF304378[13128924]
    • 5477: AF304377
      Homo sapiens ULBP1 protein mRNA, complete cds
      gi|13128922|gb|AF304377.1|AF304377[13128922]
    • 5481: AF000549
      AF000549 Human Homo sapiens genomic clone P1 clone DMPC-HFF#1-1075-D9, genomic
      survey sequence
      gi|2232072|gb|AF000549.1|AF000549[2232072]
    • 5482: NM001755
      Homo sapiens core-binding factor, beta subunit (CBFB), transcript variant 2, mRNA
      gi|13124872|ref|NM001755.1|[13124872]
    • 5483: AF172398
      Homo sapiens junctional adhesion molecule-1 mRNA, complete cds
      gi|13124448|gb|AF172398.2|AF172398[13124448]
    • 5484: AF317655
      Homo sapiens G protein-coupled receptor (GPR77) gene, complete cds
      gi|13122466|gb|AF317655.1|AF317655[13122466]
    • 5485: AF317653
      Homo sapiens G protein-coupled receptor (GPR62) gene, complete cds
      gi|13122462|gb|AF317653.1|AF317653[13122462]
    • 5486: AF317652
      Homo sapiens G protein-coupled receptor (GPR61) mRNA, complete cds
      gi|13122460|gb|AF317652.1|AF317652[13122460]
    • 5487: NM022036
      Homo sapiens G protein-coupled receptor, family C, group 5, member C (GPRC5C),
      transcript variant 1, mRNA
      gi|13112058|ref|NM022036.1|[13112058]
    • 5488: NM018653
      Homo sapiens G protein-coupled receptor, family C, group 5, member C (GPRC5C),
      transcript variant 2, mRNA
      gi|13112056|ref|NM018653.2|[13112056]
    • 5489: NM000707
      Homo sapiens arginine vasopressin receptor 1B (AVPR1B), mRNA
      gi|13112055|ref|NM000707.2|[13112055]
    • 5490: NM000706
      Homo sapiens arginine vasopressin receptor 1A (AVPR1A), mRNA
      gi|13112054|ref|NM000706.2|[13112054]
    • 5491: NM021923
      Homo sapiens fibroblast growth factor receptor-like 1 (FGFRL1), mRNA
      gi|13112053|ref|NM021923.2|[13112053]
    • 5492: NM002011
      Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 1,
      mRNA
      gi|13112051|ref|NM002011.2|[13112051]
    • 5493: NM022963
      Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 2,
      mRNA
      gi|13112049|ref|NM022963.1|[13112049]
    • 5494: NM022965
      Homo sapiens fibroblast growth factor receptor 3 (achondroplasia, thanatophoric
      dwarfism) (FGFR3), transcript variant 2, mRNA
      gi|13112047|ref|NM022965.1|[13112047]
    • 5495: NM000142
      Homo sapiens fibroblast growth factor receptor 3 (achondroplasia, thanatophoric
      dwarfism) (FGFR3), transcript variant 1, mRNA
      gi|13112046|ref|NM000142.2|[13112046]
    • 5496: NM022336
      Homo sapiens ectodysplasin 1, anhidrotic receptor (EDAR), mRNA
      gi|11641230|ref|NM022336.1|[11641230]
    • 5497: NM018654
      Homo sapiens G protein-coupled receptor, family C, group 5, member D (GPRC5D),
      mRNA
      gi|8923704|ref|NM018654.1|[8923704]
    • 5498: AF312230
      Homo sapiens histamine receptor H4 subtype mRNA, complete cds
      gi|13094918|gb|AF312230.1|AF312230[13094918]
    • 5504: AY016370
      Homo sapiens hnRNPA1 pseudogene, complete sequence; and CC chemokine receptor 8
      (CCR8) and CX3C chemokine receptor 1 (CX3CR1) genes, complete cds
      gi|13027668|gb|AY016370.1|[13027668]
    • 5505: E32517
      Scavenger receptor-like protein
      gi|13026764|dbj|E32517.1E32517[13026764]
    • 5506: E32511
      Scavenger receptor-like protein
      gi|13026758|dbj|E32511.1|E32511[13026758]
    • 5507: E32510
      Scavenger receptor-like protein
      gi|3026757|dbj|E32510.1|E32510[13026757]
    • 5508: E32509
      Scavenger receptor-like protein
      gi|13026756|dbj|E32509.1|E32509[13026756]
    • 5509: E32504
      Scavenger receptor-like protein
      gi|13026751|dbj|E32504.1|E32504[13026751]
    • 5510: E32503
      Scavenger receptor-like protein
      gi|13026750|dbj|E32503.1|E32503[13026750]
    • 5511: E60222
      Melatonin receptor expressing cell and utilization thereof
      gi|13025812|dbj|E60222.1|E60222[13025812]
    • 5512: E36078
      cDNA clone HNEAA81 encoding human seven-pass transmembrane receptor
      gi|13022480|dbj|E36078.1|E36078[13022480]
    • 5522: AJ309545
      Homo sapiens mRNA for T-cell receptor alpha chain, clone 57LSK10 (Va2, Ja45)
      gi|13016702|emb|AJ309545.1|HSA309545[13016702]
    • 5523: AF323176
      Homo sapiens death receptor-interacting protein mRNA, complete cds
      gi|12964787|gb|AF323176.1|AF323176[12964787]
    • 5524: AF329496
      Homo sapiens immunoglobulin kappa light chain gene, partial cds
      gi|12963392|gb|AF329496.1|AF329496[12963392]
    • 5529: NM015717
      Homo sapiens Langerhans cell specific c-type lectin (LANGERIN), mRNA
      gi|7657290|ref|NM015717.1|[7657290]
    • 5530: NM012329
      Homo sapiens monocyte to macrophage differentiation-associated (MMD), mRNA
      gi|6912507|ref|NM012329.1|[6912507]
    • 5571: AH009956
      Homo sapiens chromosome 12 clone pacHRARg map 12q13
      gi|12746591|gb|AH009956.2|SEG_AF311283S[12746591]
    • 5573: AF230330
      Homo sapiens angiopoietin-related protein 5 (ARP5) mRNA, complete cds
      gi|12743935|gb|AF230330.1|AF230330[12743935]
    • 5574: AF316895
      Homo sapiens alpha 2B adrenergic receptor (ADRA2B) gene, complete cds
      gi|12698669|gb|AF316895.1|AF316895[12698669]
    • 5575: NM021905
      Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript
      variant 4, mRNA
      gi|11497615|ref|NM021905.1|[11497615]
    • 5578: NM016730
      Homo sapiens folate receptor 1 (adult) (FOLR1), transcript variant 3, mRNA
      gi|9257214|ref|NM016730.1|[9257214]
    • 5579: NM016729
      Homo sapiens folate receptor 1 (adult) (FOLR1), transcript variant 4, mRNA
      gi|9257212|ref|NM016729.1|[9257212]
    • 5580: NM016725
      Homo sapiens folate receptor 1 (adult) (FOLR1), transcript variant 1, mRNA
      gi|9257206|ref|NM016725.1|[9257206]
    • 5581: NM016724
      Homo sapiens folate receptor 1 (adult) (FOLR1), transcript variant 7, mRNA
      gi|9257204|ref|NM016724.1|[9257204]
    • 5582: NM004406
      Homo sapiens deleted in malignant brain tumors 1 (DMBT1), transcript variant 1,
      mRNA
      gi|4758169|ref|NM004406.1|[4758169]
    • 5583: L27609
      Homo sapiens T-cell receptor beta gene, partial cds
      gi|457265|gb|L27609.1|HUMTCRBD[457265]
    • 5584: U65905
      U65905 Human Homo sapiens genomic, genomic survey sequence
      gi|1743863|gb|U65905.1|U65905[1743863]
    • 5585: U65904
      U65904 Human Homo sapiens genomic, genomic survey sequence
      gi|1743862|gb|U65904.1|U65904[1743862]
    • 5586: U65903
      U65903 Human Homo sapiens genomic, genomic survey sequence
      gi|1743861|gb|U65903.1|U65903[1743861]
    • 5587: NM016731
      Homo sapiens folate receptor 1 (adult) (FOLR1), transcript variant 8, mRNA
      gi|12719454|ref|NM016731.2|[12719454]
    • 5588: AF316870
      Homo sapiens T cell receptor beta chain variable region mRNA, partial cds
      gi|12711595|gb|AF316870.1|AF316870[12711595]
    • 5589: AX074315
      Sequence 29 from Patent WO0104310
      gi|12710501|emb|AX074315.1|AX074315[12710501]
    • 5590: AX074314
      Sequence 28 from Patent WO0104310
      gi|12710500|emb|AX074314.1|AX074314[12710500]
    • 5591: NM022113
      Homo sapiens kinesin family member 13A (KIF13A), mRNA
      gi|11545828|ref|NM022113.1|[11545828]
    • 5592: AF283296
      Homo sapiens interleukin-15 receptor alpha gene, 5′ regulatory region and exon
      1, partial sequence
      gi|9965299|gb|AF283296.1|AF283296[9965299]
    • 5593: NM014688
      Homo sapiens related to the N terminus of tre (RNTRE), mRNA
      gi|7661863|ref|NM014688.1|[7661863]
    • 5594: NM000916
      Homo sapiens oxytocin receptor (OXTR), mRNA
      gi|12707575|ref|NM000916.2|[12707575]
    • 5595: NM000915
      Homo sapiens oxytocin, prepro-(neurophysin I) (OXT), mRNA
      gi|12707574|ref|NM000915.2|[12707574]
    • 5596: NM004961
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, epsilon (GABRE), transcript variant 1, mRNA
      gi|12707559|ref|NM004961.2|[12707559]
    • 5597: NM021990
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, epsilon (GABRE), transcript variant 4, mRNA
      gi|12707557|ref|NM021990.1|[12707557]
    • 5598: NM021987
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, epsilon (GABRE), transcript variant 3, mRNA
      gi|12707555|ref|NM021987.1|[12707555]
    • 5599: NM021984
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, epsilon (GABRE), transcript variant 2, mRNA
      gi|12707553|ref|NM021984.1|[12707553]
    • 5600: AY011291
      Homo sapiens beta-2 adrenergic receptor (ADRB2) gene, partial cds
      gi|12699005|gb|AY011291.1|[12699005]
    • 5601: AF316894
      Homo sapiens alpha 2A adrenergic receptor (ADRA2A) gene, complete cds
      gi|12698667|gb|AF316894.1|AF316894[12698667]
    • 5602: AJ300340
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 1 and joined complete CDS
      gi|11878410|emb|AJ300340.1|HSA300340[11878410]
    • 5603: AF063605
      Homo sapiens brain my047 protein mRNA, complete cds
      gi|4071360|gb|AF063605.1|AF063605[4071360]
    • 5604: AF319440
      Homo sapiens SH2 domain-containing phosphatase anchor protein 1c (SPAP1) mRNA,
      complete cds, alternatively spliced
      gi|12667355|gb|AF319440.1|AF319440[12667355]
    • 5605: AF319439
      Homo sapiens SH2 domain-containing phosphatase anchor protein 1b (SPAP1) mRNA,
      complete cds, alternatively spliced
      gi|12667353|gb|AF319439.1|AF319439[12667353]
    • 5606: AF319438
      Homo sapiens SH2 domain-containing phosphatase anchor protein 1a (SPAP1) mRNA,
      complete cds, alternatively spliced
      gi|12667351|gb|AF319438.1|AF319438[12667351]
    • 5607: NM021912
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 3 (GABRB3), transcript variant 2, mRNA
      gi|12548787|ref|NM021912.1|[12548787]
    • 5608: NM021911
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2), transcript variant 1, mRNA
      gi|12548784|ref|NM021911.1|[12548784]
    • 5609: NM000814
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 3 (GABRB3), transcript variant 1, mRNA
      gi|12548782|ref|NM000814.2|[12548782]
    • 5610: NM000812
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA
      gi|12548775|ref|NM000812.2|[12548775]
    • 5611: NM006786
      Homo sapiens urotensin 2 (UTS2), transcript variant 2, mRNA
      gi|12056480|ref|NM006786.2|[12056480]
    • 5612: NM021995
      Homo sapiens urotensin 2 (UTS2), transcript variant 1, mRNA
      gi|12056478|ref|NM021995.1|[12056478]
    • 5613: AJ300444
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 105
      gi|1863669|emb|AJ300444.1|HSA300444[11863669]
    • 5614: AJ300443
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 104
      gi|11863668|emb|AJ300443.1|HSA300443[11863668]
    • 5615: AJ300442
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 103
      gi|11863667|emb|AJ300442.1|HSA300442[11863667]
    • 5616: AJ300441
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 102
      gi|11863666|emb|AJ300441.1|HSA300441[11863666]
    • 5617: AJ300440
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 101
      gi|11863665|emb|AJ300440.1|HSA300440[11863665]
    • 5618: AJ300439
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 100
      gi|11863664|emb|AJ300439.1|HSA300439[11863664]
    • 5619: AJ300438
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 99
      gi|11863663|emb|AJ300438.1|HSA300438[11863663]
    • 5620: AJ300437
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 98
      gi|11863662|emb|AJ300437.1|HSA300437[11863662]
    • 5621: AJ300436
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 97
      gi|11863661|emb|AJ300436.1|HSA300436[11863661]
    • 5622: AJ300435
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 96
      gi|11863660|emb|AJ300435.1|HSA300435[11863660]
    • 5623: AJ300434
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 95
      gi|11863659|emb|AJ300434.1|HSA300434[11863659]
    • 5624: AJ300433
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 94
      gi|11863658|emb|AJ300433.1|HSA300433[11863658]
    • 5625: AJ300432
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 93
      gi|11863657|emb|AJ300432.1|HSA300432[11863657]
    • 5626: AJ300431
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 92
      gi|11863656|emb|AJ300431.1|HSA300431[11863656]
    • 5627: AJ300430
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 91
      gi|11863655|emb|AJ300430.1|HSA300430[11863655]
    • 5628: AJ300429
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 90
      gi|11863654|emb|AJ300429.1|HSA300429[11863654]
    • 5629: AJ300428
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 89
      gi|11863653|emb|AJ300428.1|HSA300428[11863653]
    • 5630: AJ300427
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 88
      gi|11863652|emb|AJ300427.1|HSA300427[11863652]
    • 5631: AJ300426
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 87
      gi|11863651|emb|AJ300426.1|HSA300426[11863651]
    • 5632: AJ300425
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 86
      gi|11863650|emb|AJ300425.1|HSA300425[11863650]
    • 5633: AJ300424
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 85
      gi|11863649|emb|AJ300424.1|HSA300424[11863649]
    • 5634: AJ300423
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 84
      gi|11863648|emb|AJ300423.1|HSA300423[11863648]
    • 5635: AJ300422
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 83
      gi|11863647|emb|AJ300422.1|HSA300422[11863647]
    • 5636: AJ300421
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 82
      gi|11863646|emb|AJ300421.1|HSA300421[11863646]
    • 5637: AJ300420
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 81
      gi|11863645|emb|AJ300420.1|HSA300420[11863645]
    • 5638: AJ300419
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 80
      gi|11863644|emb|AJ300419.1|HSA300419[11863644]
    • 5639: AJ300418
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 79
      gi|11863643|emb|AJ300418.1|HSA300418[11863643]
    • 5640: AJ300417
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 78
      gi|11863642|emb|AJ300417.1|HSA300417[11863642]
    • 5641: AJ300416
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 77
      gi|11863641|emb|AJ300416.1|HSA300416[11863641]
    • 5642: AJ300415
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 76
      gi|1863640|emb|AJ300415.1|HSA300415[11863640]
    • 5643: AJ300414
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 75
      gi|11863639|emb|AJ300414.1|HSA300414[11863639]
    • 5644: AJ300413
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 74
      gi|11863638|emb|AJ300413.1|HSA300413[11863638]
    • 5645: AJ300412
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 73
      gi|11863637|emb|AJ300412.1|HSA300412[11863637]
    • 5646: AJ300411
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 72
      gi|11863636|emb|AJ300411.1|HSA300411[11863636]
    • 5647: AJ300410
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 71
      gi|11863635|emb|AJ300410.1|HSA300410[11863635]
    • 5648: AJ300409
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 70
      gi|11863634|emb|AJ300409.1|HSA300409[11863634]
    • 5649: AJ300408
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 69
      gi|11863633|emb|AJ300408.1|HSA300408[11863633]
    • 5650: AJ300407
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 68
      gi|11863632|emb|AJ300407.1|HSA300407[11863632]
    • 5651: AJ300406
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 67
      gi|11863631|emb|AJ300406.1|HSA300406[11863631]
    • 5652: AJ300405
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 66
      gi|11863630|emb|AJ300405.1|HSA300405[11863630]
    • 5653: AJ300404
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 65
      gi|11863629|emb|AJ300404.1|HSA300404[11863629]
    • 5654: AJ300403
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 64
      gi|11863628|emb|AJ300403.1|HSA300403[11863628]
    • 5655: AJ300402
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 63
      gi|11863627|emb|AJ300402.1|HSA300402[11863627]
    • 5656: AJ300401
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 62
      gi|11863626|emb|AJ300401.1|HSA300401[11863626]
    • 5657: AJ300400
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 61
      gi|11863625|emb|AJ300400.1|HSA300400[11863625]
    • 5658: AJ300399
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 60
      gi|11863624|emb|AJ300399.1|HSA300399[11863624]
    • 5659: AJ300398
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 59
      gi|11863623|emb|AJ300398.1|HSA300398[11863623]
    • 5660: AJ300397
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 58
      gi|11863622|emb|AJ300397.1|HSA300397[11863622]
    • 5661: AJ300396
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 57
      gi|11863621|emb|AJ300396.1|HSA300396[11863621]
    • 5662: AJ300395
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 56
      gi|11863620|emb|AJ300395.1|HSA300395[11863620]
    • 5663: AJ300394
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 55
      gi|11863619|emb|AJ300394.1|HSA300394[11863619]
    • 5664: AJ300393
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 54
      gi|11863618|emb|AJ300393.1|HSA300393[11863618]
    • 5665: AJ300392
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 53
      gi|11863617|emb|AJ300392.1|HSA300392[11863617]
    • 5666: AJ300391
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 52
      gi|11863616|emb|AJ300391.1|HSA300391[11863616]
    • 5667: AJ300390
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 51
      gi|11863615|emb|AJ300390.1|HSA300390[11863615]
    • 5668: AJ300389
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 50
      gi|11863614|emb|AJ300389.1|HSA300389[11863614]
    • 5669: AJ300388
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 49
      gi|11863613|emb|AJ300388.1|HSA300388[11863613]
    • 5670: AJ300387
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 48
      gi|11863612|emb|AJ300387.1|HSA300387[11863612]
    • 5671: AJ300386
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 47
      gi|11863611|emb|AJ300386.1|HSA300386[11863611]
    • 5672: AJ300385
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 46
      gi|11863610|emb|AJ300385.1|HSA300385[11863610]
    • 5673: AJ300384
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 45
      gi|11863609|emb|AJ300384.1HSA300384[11863609]
    • 5674: AJ300383
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 44
      gi|11863608|emb|AJ300383.1|HSA300383[11863608]
    • 5675: AJ300382
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 43
      gi|11863607|emb|AJ300382.1|HSA300382[11863607]
    • 5676: AJ300381
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 42
      gi|11863606|emb|AJ300381.1|HSA300381[11863606]
    • 5677: AJ300380
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 41
      gi|11863605|emb|AJ300380.1|HSA300380[11863605]
    • 5678: AJ300379
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 40
      gi|11863604|emb|AJ300379.1|HSA300379[11863604]
    • 5679: AJ300378
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 39
      gi|1863603|emb|AJ300378.1|HSA300378[11863603]
    • 5680: AJ300377
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 38
      gi|11863602|emb|AJ300377.1|HSA300377[11863602]
    • 5681: AJ300376
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 37
      gi|1863601|emb|AJ300376.1|HSA300376[11863601]
    • 5682: AJ300375
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 36
      gi|1863600|emb|AJ300375.1|HSA300375[11863600]
    • 5683: AJ300374
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 35
      gi|11863599|emb|AJ300374.1|HSA300374[11863599]
    • 5684: AJ300373
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 34
      gi|11863598|emb|AJ300373.1|HSA300373[11863598]
    • 5685: AJ300372
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 33
      gi|11863597|emb|AJ300372.1|HSA300372[11863597]
    • 5686: AJ300371
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 32
      gi|11863596|emb|AJ300371.1|HSA300371[11863596]
    • 5687: AJ300370
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 31
      gi|11863595|emb|AJ300370.1|HSA300370[11863595]
    • 5688: AJ300369
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 30
      gi|11863594|emb|AJ300369.1|HSA300369[11863594]
    • 5689: AJ300368
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 29
      gi|11863593|emb|AJ300368.1|HSA300368[11863593]
    • 5690: AJ300367
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 28
      gi|11863592|emb|AJ300367.1|HSA300367[11863592]
    • 5691: AJ300366
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 27
      gi|11863591|emb|AJ300366.1|HSA300366[11863591]
    • 5692: AJ300365
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 26
      gi|11863590|emb|AJ300365.1|HSA300365[11863590]
    • 5693: AJ300364
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 25
      gi|11863589|emb|AJ300364.1|HSA300364[11863589]
    • 5694: AJ300363
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 24
      gi|11863588|emb|AJ300363.1|HSA300363[11863588]
    • 5695: AJ300362
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 23
      gi|11863587|emb|AJ300362.1|HSA300362[11863587]
    • 5696: AJ300361
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 22
      gi|11863586|emb|AJ300361.1|HSA300361[11863586]
    • 5697: AJ300360
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 21
      gi|11863585|emb|AJ300360.1|HSA300360[11863585]
    • 5698: AJ300359
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 20
      gi|11863584|emb|AJ300359.1|HSA300359[11863584]
    • 5699: AJ300358
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 19
      gi|11863583|emb|AJ300358.1|HSA300358[11863583]
    • 5700: AJ300357
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 18
      gi|11863582|emb|AJ300357.1|HSA300357[11863582]
    • 5701: AJ300356
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 17
      gi|11863581|emb|AJ300356.1|HSA300356[11863581]
    • 5702: AJ300355
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 16
      gi|11863580|emb|AJ300355.1|HSA300355[11863580]
    • 5703: AJ300354
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 15
      gi|11863579|emb|AJ300354.1|HSA300354[11863579]
    • 5704: AJ300353
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 14
      gi|11863578|emb|AJ300353.1|HSA300353[11863578]
    • 5705: AJ300352
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 13
      gi|11863577|emb|AJ300352.1|HSA300352[11863577]
    • 5706: AJ300351
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 12
      gi|11863576|emb|AJ300351.1|HSA300351[11863576]
    • 5707: AJ300350
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 11
      gi|11863575|emb|AJ300350.1|HSA300350[11863575]
    • 5708: AJ300349
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 10
      gi|11863574|emb|AJ300349.1|HSA300349[11863574]
    • 5709: AJ300348
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 9
      gi|11863573|emb|AJ300348.1|HSA300348[11863573]
    • 5710: AJ300347
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 8
      gi|11863572|emb|AJ300347.1|HSA300347[11863572]
    • 5711: AJ300346
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 7
      gi|11863571|emb|AJ300346.1|HSA300346[11863571]
    • 5712: AJ300345
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 6
      gi|11863570|emb|AJ300345.1|HSA300345[11863570]
    • 5713: AJ300344
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 5
      gi|11863569|emb|AJ300344.1|HSA300344[11863569]
    • 5714: AJ300343
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 4
      gi|11863568|emb|AJ300343.1|HSA300343[11863568]
    • 5715: AJ300342
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 3
      gi|11863567|emb|AJ300342.1|HSA300342[11863567]
    • 5716: AJ300341
      Homo sapiens partial RYR2 gene for ryanodine receptor 2, exon 2
      gi|11863566|emb|AJ300341.1|HSA300341[11863566]
    • 5717: NM000832
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), transcript variant NR1-1, mRNA
      gi|11496970|ref|NM000832.4|[11496970]
    • 5718: NM021709
      Homo sapiens CD27-binding (Siva) protein (SIVA), transcript variant 2, mRNA
    • 5719: NM006427
      Homo sapiens CD27-binding (Siva) protein (SIVA), transcript variant 1, mRNA
      gi|11277467|ref|NM006427.2|[11277467]
    • 5720: NM016232
      Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), mRNA
      gi|11136631|ref|NM016232.2|[11136631]
    • 5721: AF202091
      Homo sapiens hypocretin receptor-2 (HCRTR2) gene, exon 7 and complete cds
      gi|11055242|gb|AF202091.1|F202078S14[11055242]
    • 5722: AF202090
      Homo sapiens hypocretin receptor-2 (HCRTR2) gene, exon 6
      gi|11055241|gb|AF202090.1|F202078S13[11055241]
    • 5723: AF202089
      Homo sapiens hypocretin receptor-2 (HCRTR2) gene, exon 5
      gi|110552400gb|AF202089.1|F202078S12[11055240]
    • 5724: AF202088
      Homo sapiens hypocretin receptor-2 (HCRTR2) gene, exon 4
      gi|11055239|gb|AF202088.1|F202078S11[11055239]
    • 5725: AF202087
      Homo sapiens hypocretin receptor-2 (HCRTR2) gene, exon 3
      gi|11055238|gb|AF202087.1|F202078S10[11055238]
    • 5726: AF202086
      Homo sapiens hypocretin receptor-2 (HCRTR2) gene, exon 2
      gi|11055237|gb|AF202086.1|F202078S09[11055237]
    • 5727: AF202085
      Homo sapiens hypocretin receptor-2 (HCRTR2) gene, exon 1
      gi|11055236|gb|AF202085.1|F202078S08[11055236]
    • 5728: AF202084
      Homo sapiens hypocretin receptor-1 (HCRTR1) gene, exon 7 and complete cds
      gi|11055235|gb|AF202084.1|F202078S07[11055235]
    • 5729: AF202083
      Homo sapiens hypocretin receptor-1 (HCRTR1) gene, exon 6
      gi|11055234|gb|AF202083.1|F202078S06[11055234]
    • 5730: AF202082
      Homo sapiens hypocretin receptor-1 (HCRTR1) gene, exon 5
      gi|11055233|gb|AF202082.1|F202078S05[11055233]
    • 5731: AF202081
      Homo sapiens hypocretin receptor-1 (HCRTR1) gene, exon 4
      gi|11055232|gb|AF202081.1|F202078S04[11055232]
    • 5732: AF202080
      Homo sapiens hypocretin receptor-1 (HCRTR1) gene, exon 3
      gi|11055231|gb|AF202080.1|F202078S03[11055231]
    • 5733: AF202079
      Homo sapiens hypocretin receptor-1 (HCRTR1) gene, exon 2
      gi|110552300gb|AF202079.1|F202078S02[11055230]
    • 5734: AF202078
      Homo sapiens hypocretin receptor-1 (HCRTR1) gene, exon 1
      gi|11055229|gb|AF202078.1|F202078S01[11055229]
    • 5735: AH009943
      Homo sapiens hypocretin receptor-1 (HCRTR1) and hypocretin receptor-2 (HCRTR2)
      genes, complete cds
      gi|11055228|gb|AH009943.1|SEG_F202078S[11055228]
    • 5736: NM021602
      Homo sapiens CD79B antigen (immunoglobulin-associated beta) (CD79B), transcript
      variant 2, mRNA
      gi|11038675|ref|NM021602.1|[11038675]
    • 5737: NM000626
      Homo sapiens CD79B antigen (immunoglobulin-associated beta) (CD79B), transcript
      variant 1, mRNA
      gi|11038673|ref|NM000626.1|[11038673]
    • 5738: NM021601
      Homo sapiens CD79A antigen (immunoglobulin-associated alpha) (CD79A), transcript
      variant 2, mRNA
      gi|11038671|ref|NM021601.1|[11038671]
    • 5739: NM007327
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), transcript variant NR1-3, mRNA
      gi|11038636|ref|NM007327.1|[11038636]
    • 5740: NM021569
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), transcript variant NR1-2, mRNA
      gi|11038634|ref|NM021569.1|[11038634]
    • 5743: NM021270
      Homo sapiens leukocyte-associated Ig-like receptor 2 (LAIR2), transcript variant
      2, mRNA
      gi|10947102|ref|NM021270.1|[10947102]
    • 5744: NM002288
      Homo sapiens leukocyte-associated Ig-like receptor 2 (LAIR2), transcript variant
      1, mRNA
      gi|10947100|ref|NM002288.2|[10947100]
    • 5745: NM004041
      Homo sapiens arrestin, beta 1 (ARRB1), transcript variant 1, mRNA
      gi|10880135|ref|NM004041.2|[10880135]
    • 5746: NM020251
      Homo sapiens arrestin, beta 1 (ARRB1), transcript variant 2, mRNA
      gi|10880133|ref|NM020251.1|[10880133]
    • 5747: NM000872
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) (HTR7), transcript variant a, mRNA
      gi|10880132|ref|NM000872.2|[10880132]
    • 5748: NM019860
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) (HTR7), transcript variant b, mRNA
      gi|10880130|ref|NM019860.1|[10880130]
    • 5749: NM019859
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) (HTR7), transcript variant d, mRNA
      gi|10880128|ref|NM019859.1|[10880128]
    • 5750: NM004302
      Homo sapiens activin A receptor, type IB (ACVR1B), transcript variant 1, mRNA
      gi|10862695|ref|NM004302.2|[10862695]
    • 5751: NM020328
      Homo sapiens activin A receptor, type IB (ACVR1B), transcript variant 3, mRNA
      gi|10862693|ref|NM020328.1|[10862693]
    • 5752: NM020327
      Homo sapiens activin A receptor, type IB (ACVR1B), transcript variant 2, mRNA
      gi|10862691|ref|NM020327.1|[10862691]
    • 5753: NM020525
      Homo sapiens interleukin 22 (IL22), mRNA
      gi|10092624|ref|NM020525.1|[10092624]
    • 5754: NM000407
      Homo sapiens glycoprotein Ib (platelet), beta polypeptide (GP1BB), mRNA
      gi|9945387|ref|NM000407.31[9945387]
    • 5755: NM018971
      Homo sapiens G protein-coupled receptor 27 (GPR27), mRNA
      gi|9506746|ref|NM018971.1|[9506746]
    • 5756: NM017455
      Homo sapiens stromal cell derived factor receptor 1 (SDFR1), transcript variant
      alpha, mRNA
      gi|9257239|ref|NM017455.1|[9257239]
    • 5757: NM002197
      Homo sapiens aconitase 1, soluble (ACO1), mRNA
      gi|8659554|ref|NM002197.1|[8659554]
    • 5758: NM005242
      Homo sapiens coagulation factor II (thrombin) receptor-like 1 (F2RL1), mRNA
      gi|8051581|ref|NM005242.2|[8051581]
    • 5759: NM016388
      Homo sapiens T-cell receptor interacting molecule (TRIM), mRNA
      gi|7706744|ref|NM016388.1|[7706744]
    • 5760: NM016334
      Homo sapiens putative G-protein coupled receptor (SH120), mRNA
      gi|7706703|ref|NM016334.1|[7706703]
    • 5761: NM016318
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 2 (P2RX2), mRNA
      gi|7706628|ref|NM016318.1|[7706628]
    • 5762: NM016602
      Homo sapiens G protein-coupled receptor 2 (GPR2), mRNA
      gi|7705315|ref|NM016602.1|[7705315]
    • 5763: NM013964
      Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-alpha, mRNA
      gi|7669525|ref|NM013964.1|[7669525]
    • 5764: NM013962
      Homo sapiens neuregulin 1 (NRG1), transcript variant GGF2, mRNA
      gi|7669523|ref|NM013962.1|[7669523]
    • 5765: NM013961
      Homo sapiens neuregulin 1 (NRG1), transcript variant GGF, mRNA
      gi|7669521|ref|NM013961.1|[7669521]
    • 5766: NM013960
      Homo sapiens neuregulin 1 (NRG1), transcript variant ndf43, mRNA
      gi|7669519|ref|NM013960.1|[7669519]
    • 5767: NM013959
      Homo sapiens neuregulin 1 (NRG1), transcript variant SMDF, mRNA
      gi|7669517|ref|NM013959.1|[7669517]
    • 5768: NM013958
      Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-beta3, mRNA
      gi|7669515|ref|NM013958.1|[7669515]
    • 5769: NM013957
      Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-beta2, mRNA
      gi|7669513|ref|NM013957.1|[7669513]
    • 5770: NM013956
      Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-beta1, mRNA
      gi|7669511|ref|NM013956.1|[7669511]
    • 5771: NM007334
      Homo sapiens killer cell lectin-like receptor subfamily D, member 1 (KLRD1), transcript variant 2, mRNA
      gi|7669498|ref|NM007334.1|[7669498]
    • 5772: NM002262
      Homo sapiens killer cell lectin-like receptor subfamily D, member 1 (KLRD1), transcript variant 1, mRNA
      gi|7669497|ref|NM002262.21[7669497]
    • 5773: NM007319
      Homo sapiens presenilin 1 (Alzheimer disease 3) (PSEN1), transcript variant I-374., mRNA
      gi|7549814|ref|NM007319.1|[7549814]
    • 5774: NM007318
      Homo sapiens presenilin 1 (Alzheimer disease 3) (PSEN1), transcript variant I-463, mRNA
      gi|7549812|ref|NM007318.1|[7549812]
    • 5775: NM007333
      Homo sapiens killer cell lectin-like receptor subfamily C, member 3 (KLRC3), transcript variant NKG2-H, mRNA
      gi|7262385|ref|NM007333.1|[7262385]
    • 5776: NM007328
      Homo sapiens killer cell lectin-like receptor subfamily C, member 1 (KLRC1), transcript variant NKG2-B, mRNA
      gi|7262383|ref|NM007328.1|[7262383]
    • 5777: NM002259
      Homo sapiens killer cell lectin-like receptor subfamily C, member 1 (KLRC1), transcript variant NKG2-A, mRNA
      gi|7262382|ref|NM002259.2|[7262382]
    • 5778: NM006350
      Homo sapiens follistatin (FST), transcript variant FST317, mRNA
      gi|7242223|ref|NM006350.2|[7242223]
    • 5779: NM013409
      Homo sapiens follistatin (FST), transcript variant FST344, mRNA
      gi|7242221|ref|NM013409.1|[7242221]
    • 5780: NM012486
      Homo sapiens presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2,
      mRNA
      gi|7108359|ref|NM012486.1|[7108359]
    • 5781: NM012485
      Homo sapiens hyaluronan-mediated motility receptor (RHAMM) (HMMR), transcript variant 2, mRNA
      gi|7108350|ref|NM012485.1|[7108350]
    • 5782: NM012484
      Homo sapiens hyaluronan-mediated motility receptor (RHAMM) (HMMR), transcript variant 1, mRNA
      gi|7108348|ref|NM012484.1|[7108348]
    • 5783: NM012428
      Homo sapiens stromal cell derived factor receptor 1 (SDFR1), transcript variant
      beta, mRNA
      gi|6912645|ref|NM012428.1|[6912645]
    • 5784: NM012226
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 2 (P2RX2), mRNA
      gi|6912565|ref|NM012226.1|[6912565]
    • 5785: NM012369
      Homo sapiens olfactory receptor, family 2, subfamily F, member 1 (OR2F1), mRNA
      gi|6912557|ref|NM012369.1|[6912557]
    • 5786: NM007325
      Homo sapiens glutamate receptor, ionotrophic, AMPA 3 (GRIA3), transcript variant
      flip, mRNA
      gi|6598324|ref|NM007325.1|[6598324]
    • 5787: NM000632
      Homo sapiens integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide) (ITGAM), mRNA
      gi|6006013|ref|NM000632.21[6006013]
    • 5788: NM007097
      Homo sapiens clathrin, light polypeptide (Lcb) (CLTB), mRNA
      gi|6005994|ref|NM007097.1|[6005994]
    • 5789: NM000655
      Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL), mRNA
      gi|5713320|ref|NM000655.2|[5713320]
    • 5790: NM005751
      Homo sapiens A kinase (PRKA) anchor protein (yotiao) 9 (AKAP9), mRNA
      gi|5032230|ref|NM005751.1|[5032230]
    • 5791: NM005691
      Homo sapiens ATP-binding cassette, sub-family C(CFTR/MRP), member 9 (ABCC9), transcript variant SUR2A, mRNA
      gi|5032134|ref|NM005691.1|[5032134]
    • 5792: NM005534
      Homo sapiens interferon gamma receptor 2 (interferon gamma transducer 1) (IFNCR2), mRNA
      gi|5031782|ref|NM005534.1|[5031782]
    • 5793: NM005682
      Homo sapiens G protein-coupled receptor 56 (GPR56), mRNA
      gi|5031724|ref|NM005682.1|[5031724]
    • 5794: NM005446
      Homo sapiens purinergic receptor P2X-like 1, orphan receptor (P2RXL1), mRNA
      gi|4885534|ref|NM005446.1|[4885534]
    • 5795: NM004958
      Homo sapiens FK506 binding protein 12-rapamycin associated protein 1 (FRAP1), mRNA
      gi|4826729|ref|NM004958.1|[4826729]
    • 5796: NM004495
      Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-gamma, mRNA
      gi|4758525|ref|NM004495.1|[4758525]
    • 5797: NM003995
      Homo sapiens natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (NPR2), mRNA
      gi|4580421|ref|NM003995.2|[4580421]
    • 5798: NM003994
      Homo sapiens KIT ligand (KITLG), mRNA
      gi|4580419|ref|NM003994.2|[4580419]
    • 5799: NM000115
      Homo sapiens endothelin receptor type B (EDNRB), transcript variant 1, mRNA
      gi|4557546|ref|NM000115.1|[4557546]
    • 5800: NM000734
      Homo sapiens CD3Z antigen, zeta polypeptide (TiT3 complex) (CD3Z), mRNA
      gi|4557430|ref|NM000734.1|[4557430]
    • 5801: NM003856
      Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), mRNA
      gi|4507244|ref|NM003856.1|[4507244]
    • 5802: NM002980
      Homo sapiens secretin receptor (SCTR), mRNA
      gi|4506824|ref|NM002980.1|[4506824]
    • 5803: NM000447
      Homo sapiens presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1,
      mRNA
      gi|4506164|ref|NM000447.1|[4506164]
    • 5804: NM000021
      Homo sapiens presenilin 1 (Alzheimer disease 3) (PSEN1), transcript variant I-467, mRNA
      gi|4506162|ref|NM000021.1|[4506162]
    • 5805: NM000907
      Homo sapiens natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (NPR2), mRNA
      gi|4505436|ref|NM000907.1|[4505436]
    • 5806: NM000899
      Homo sapiens KIT ligand (KITLG), mRNA
      gi|4505174|ref|NM000899.1|[4505174]
    • 5807: NM002353
      Homo sapiens tumor-associated calcium signal transducer 2 (TACSTD2), mRNA
      gi|4505056|ref|NM002353.1|[4505056]
    • 5808: NM002261
      Homo sapiens killer cell lectin-like receptor subfamily C, member 3 (KLRC3), transcript variant NKG2-E, mRNA
      gi|4504884|ref|NM002261.1|[4504884]
    • 5809: NM000836
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2D (GRIN2D),
      mRNA
      gi|4504130|ref|NM000836.1|[4504130]
    • 5810: NM000828
      Homo sapiens glutamate receptor, ionotrophic, AMPA 3 (GRIA3), transcript variant
      flop, mRNA
      gi|4504114|ref|NM000828.1|[4504114]
    • 5811: NM000813
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2), transcript variant 2, mRNA
      gi|4503864|ref|NM000813.1|[4503864]
    • 5812: NM003991
      Homo sapiens endothelin receptor type B (EDNRB), transcript variant 2, mRNA
      gi|4503466|ref|NM003991.1|[4503466]
    • 5813: NM001337
      Homo sapiens chemokine (C-X3-C) receptor 1 (CX3CR1), mRNA
      gi|4503170|ref|NM001337.1|[4503170]
    • 5814: NM001834
      Homo sapiens clathrin, light polypeptide (Lcb) (CLTB), transcript variant nonbrain, mRNA
      gi|4502900|ref|NM001834.1|[4502900]
    • 5815: NM001783
      Homo sapiens CD79A antigen (immunoglobulin-associated alpha) (CD79A), transcript
      variant 1, mRNA
      gi|4502684|ref|NM001783.1|[4502684]
    • 5816: AF277897
      Homo sapiens truncated epidermal growth factor receptor (EGFR) mRNA, partial cds; alternatively spliced
      gi|12658300|gb|AF277897.1|AF277897[12658300]
    • 5817: AF192403
      Homo sapiens ETL protein (ETL) mRNA, complete cds
      gi|11225482|gb|AF192403.1|AF192403[11225482]
    • 5818: AF259263
      Homo sapiens toll-like receptor 9 form B (TLR9) mRNA, complete cds; alternatively spliced
      gi|8099653|gb|AF259263.1|AF259263[8099653]
    • 5819: AF259262
      Homo sapiens toll-like receptor 9 form A (TLR9) mRNA, complete cds; alternatively spliced
      gi|8099651|gb|AF259262.1|AF259262[8099651]
    • 5820: AF246971
      Homo sapiens Toll-like receptor 8 (TLR8) mRNA, complete cds
      gi|7576932|gb|AF246971.1|AF246971[7576932]
    • 5821: AF240467
      Homo sapiens toll-like receptor 7 (TLR7) mRNA, complete cds
      gi|7330280|gb|AF240467.1|AF240467[7330280]
    • 5822: AF230073
      Homo sapiens sialoadhesin mRNA, complete cds
      gi|12656129|gb|AF230073.1|AF230073[12656129]
    • 5823: BC000783
      Homo sapiens, calcitonin gene-related peptide-receptor component protein, clone
      MGC:804, mRNA, complete cds
      gi|12653974|gb|BC000783.1|BC000783[12653974]
    • 5824: NM016184
      Homo sapiens C-type (calcium dependent, carbohydrate-recognition domain) lectin,
      superfamily member 6 (CLECSF6), mRNA
      gi|7705337|ref|NM016184.1|[7705337]
    • 5825: AF242540
      Homo sapiens NK cell type I receptor protein 2B4 (2B4) mRNA, complete cds, alternatively spliced
      gi|12642415|gb|AF242540.1|AF242540[12642415]
    • 5826: NM020979
      Homo sapiens adaptor protein with pleckstrin homology and src homology 2 domains
      (APS), mRNA
      gi|10280625|ref|NM020979.1|[10280625]
    • 5827: NM018557
      Homo sapiens low density lipoprotein-related protein 1B (deleted in tumors) (LRP1B), mRNA
      gi|9055269|ref|NM018557.1|[9055269]
    • 5828: NM012452
      Homo sapiens transmembrane activator and CAML interactor (TACI), mRNA
      gi|6912693|ref|NM012452.1|[6912693]
    • 5829: NM005338
      Homo sapiens huntingtin interacting protein 1 (HIP1), mRNA
      gi|12545385|ref|NM005338.3|[12545385]
    • 5830: AF321238
      Homo sapiens T-cell receptor variable beta-chain 15 mRNA, partial cds
      gi|2484115|gb|AF321238.1|AF321238[12484115]
    • 5831: AF125253
      Homo sapiens truncated epidermal growth factor receptor precursor (EGFR) mRNA,
      complete cds
      gi|1200221|gb|AF125253.1|AF125253[12002211]
    • 5832: NM014211
      Homo sapiens gamma aminobutyric acid (GABA) A receptor, pi (GABRP), mRNA
      gi|7657105|ref|NM014211.1|[7657105]
    • 5833: AF283463
      Homo sapiens Nogo receptor mRNA, complete cds
      gi|12407652|gb|AF283463.1|AF283463[12407652]
    • 5834: AF224266
      Homo sapiens four alpha helix cytokine (ZCYTO10) mRNA, ZCYTO10-1 allele,
      complete cds
      gi|7109206|gb|AF224266.1|AF224266[7109206]
    • 5837: AB045370
      Homo sapiens mRNA for histamine H4 receptor HH4R, complete cds
      gi|12248411|dbj|AB045370.1|AB045370[12248411]
    • 5838: AB045369
      Homo sapiens mRNA for histamine H3 receptor HH3R, complete cds
      gi|12248409|dbj|AB045369.1|AB045369[12248409]
    • 5840: NM016363
      Homo sapiens glycoprotein VI (platelet) (GP6), mRNA
      gi|7705956|ref|NM016363.1|[7705956]
    • 5841: NM022139
      Homo sapiens GDNF family receptor alpha 4 (GFRA4), mRNA
      gi|11545874|ref|NM022139.1|[11545874]
    • 5842: NM004403
      Homo sapiens deafness, autosomal dominant 5 (DFNA5), mRNA
      gi|4758153|ref|NM004403.1|[4758153]
    • 5847: AF308156
      Homo sapiens HERV-E LTR/leader long terminal repeat, complete sequence; and endothelin B receptor mRNA, partial cds
      gi|12239519|gb|AF308156.1|AF308156[12239519]
    • 5850: NM022789
      Homo sapiens interleukin 17E (IL17E), mRNA
      gi|12232484|ref|NM022789.1|[12232484]
    • 5851: AX054991
      Sequence 3 from Patent WO0073451
      gi|12228357|emb|AX054991.1|AX054991[12228357]
    • 5852: AX054989
      Sequence 1 from Patent WO0073451
      gi|12228355|emb|AX054989.1|AX054989[12228355]
    • 5853: AJ278581
      Homo sapiens DREV gene and IGSF6 gene for immunoglobulin superfamily 6 protein
      gi|12053852|emb|AJ278581.1|HSA278581[12053852]
    • 5854: AJ302556
      Homo sapiens 6M1-3*02 gene for olfactory receptor, cell line OLGA olfactory receptor
      gi|12140483|emb|AJ302556.1|HSA302556[12140483]
    • 5855: AJ302555
      Homo sapiens 6M1-3*02 gene for olfactory receptor, cell line SA olfactory receptor
      gi|12140479|emb|AJ302555.1|HSA302555[12140479]
    • 5856: AJ302554
      Homo sapiens 6M1-3*02 gene for olfactory receptor, cell line KR3598 olfactory receptor
      gi|12140476|emb|AJ302554.1|HSA302554[12140476]
    • 5857: AJ302553
      Homo sapiens 6M1-3*02 gene for olfactory receptor, cell line BM19.7 olfactory receptor
      gi|12140472|emb|AJ302553.1|HSA302553[12140472]
    • 5858: AJ302552
      Homo sapiens 6M1-3*02 gene for olfactory receptor, cell line BM28.7 olfactory receptor
      gi|12140468|emb|AJ302552.1|HSA302552[12140468]
    • 5859: AF209481
      Homo sapiens probable mannose binding C-type lectin DC-SIGNR gene, exons 3-8, and complete cds
      gi|12084794|gb|AF209481.2|AF209480S2[12084794]
    • 5860: AH009824
      Homo sapiens chromosome 19 probable mannose binding C-type lectin DC-SIGNR (abc)
      gene, complete cds
      gi|12084793|gb|AH009824.2|SEG_AF209480S[12084793]
    • 5861: AF313449
      Homo sapiens P2Y12 platelet ADP receptor mRNA, complete cds
      gi|1208390|gb|AF313449.1|AF313449[12083901]
    • 5884: AH009659
      Homo sapiens RON gene, partial sequence
      gi|9621821|gb|AH009659.1|SEG_HSRONPO[9621821]
    • 5885: NM002351
      Homo sapiens SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) (SH2D1A), mRNA
      gi|4506922|ref|NM002351.1|[4506922]
    • 5886: NM000171
      Homo sapiens glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man
      syndrome) (GLRA1), mRNA
      gi|4504018|ref|NM000171.1|[4504018]
    • 5887: NM000569
      Homo sapiens Fc fragment of IgG, low affinity 111a, receptor for (CD16) (FCGR3A), mRNA
      gi|12056966|ref|NM000569.2|[12056966]
    • 5888: NM000802
      Homo sapiens folate receptor 1 (adult) (FOLR1), transcript variant 2, mRNA
      gi|12056965|ref|NM000802.2|[12056965]
    • 5889: NM003979
      Homo sapiens retinoic acid induced 3 (RA13), mRNA
      gi|12056470|ref|NM003979.2|[12056470]
    • 5900: AJ302633
      Homo sapiens 6M1-02P*02 gene for olfactory receptor, cell line BM28.7
      gi|12054481|emb|AJ302633.1|HSA302633[12054481]
    • 5910: AJ302623
      Homo sapiens 6M1-18*02 gene for olfactory receptor, cell line KR3598
      gi|12054470|emb|AJ302623.1|HSA302623[12054470]
    • 5911: AJ302622
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line AMAI
      gi|12054468|emb|AJ302622.1|HSA302622[12054468]
    • 5912: AJ302621
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line OLGA
      gi|12054466|emb|AJ302621.1|HSA302621[12054466]
    • 5913: AJ302620
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line YAR
      gi|12054464|emb|AJ302620.1|HSA302620[12054464]
    • 5914: AJ302619
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line SA
      gi|2054462|emb|AJ302619.1|HSA302619[12054462]
    • 5915: AJ302618
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line WT51
      gi|12054460|emb|AJ302618.1|HSA302618[12054460]
    • 5916: AJ302617
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line H2LCL
      gi|12054458|emb|AJ302617.1|HSA302617[12054458]
    • 5917: AJ302616
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line LG2
      gi|2054456|emb|AJ302616.1|HSA302616[12054456]
    • 5918: AJ302615
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line BM19.7
      gi|12054454|emb|AJ302615.1|HSA302615[12054454]
    • 5919: AJ302614
      Homo sapiens 6M1-18*01 gene for olfactory receptor, cell line BM28.7
      gi|12054452|emb|AJ302614.1|HSA302614[12054452]
    • 5920: AJ302613
      Homo sapiens 6M1-16*03 gene for olfactory receptor, cell line AMAI
      gi|12054450|emb|AJ302613.1|HSA302613[12054450]
    • 5921: AJ302612
      Homo sapiens 6M1-16*03 gene for olfactory receptor, cell line BM19.7
      gi|12054448|emb|AJ302612.1|HSA302612[12054448]
    • 5922: AJ302611
      Homo sapiens 6M1-16*02 gene for olfactory receptor, cell line BM28.7
      gi|12054446|emb|AJ302611.1|HSA302611[12054446]
    • 5923: AJ302610
      Homo sapiens 6M1-16*01 gene for olfactory receptor, cell line OLGA
      gi|12054444|emb|AJ302610.1|HSA302610[12054444]
    • 5924: AJ302609
      Homo sapiens 6M1-16*01 gene for olfactory receptor, cell line YAR
      gi|12054442|emb|AJ302609.1|HSA302609[12054442]
    • 5925: AJ302608
      Homo sapiens 6M1-16*01 gene for olfactory receptor, cell line SA
      gi|12054440|emb|AJ302608.1|HSA302608[12054440]
    • 5926: AJ302607
      Homo sapiens 6M1-16*01 gene for olfactory receptor, cell line WT51
      gi|12054438|emb|AJ302607.1|HSA302607[12054438]
    • 5927: AJ302606
      Homo sapiens 6M1-16*01 gene for olfactory receptor, cell line H2LCL
      gi|12054436|emb|AJ302606.1|HSA302606[12054436]
    • 5928: AJ302605
      Homo sapiens 6M1-16*01 gene for olfactory receptor, cell line KR3598
      gi|12054434|emb|AJ302605.1|HSA302605[12054434]
    • 5929: AJ302604
      Homo sapiens 6M1-16*01 gene for olfactory receptor, cell line LG2
      gi|2054432|emb|AJ302604.1|HSA302604[12054432]
    • 5930: AJ302603
      Homo sapiens 6M1-15*03 gene for olfactory receptor, cell line AMAI
      gi|12054430|emb|AJ302603.1|HSA302603[12054430]
    • 5931: AJ302602
      Homo sapiens 6M1-15*02 gene for olfactory receptor, cell line WT51
      gi|12054428|emb|AJ302602.1|HSA302602[12054428]
    • 5932: AJ302601
      Homo sapiens 6M1-15*01 gene for olfactory receptor, cell line OLGA
      gi|12054426|emb|AJ302601.1|HSA302601[12054426]
    • 5933: AJ302600
      Homo sapiens 6M1-15*01 gene for olfactory receptor, cell line YAR
      gi|12054424|emb|AJ302600.1|HSA302600[12054424]
    • 5934: AJ302599
      Homo sapiens 6M1-15*01 gene for olfactory receptor, cell line SA
      gi|12054422|emb|AJ302599.1|HSA302599[12054422]
    • 5935: AJ302598
      Homo sapiens 6M1-15*01 gene for olfactory receptor, cell line H2LCL
      gi|12054420|emb|AJ302598.1|HSA302598[12054420]
    • 5936: AJ302597
      Homo sapiens 6M1-15*01 gene for olfactory receptor, cell line KR3598
      gi|12054418|emb|AJ302597.1|HSA302597[12054418]
    • 5937: AJ302596
      Homo sapiens 6M1-15*01 gene for olfactory receptor, cell line LG2
      gi|12054416|emb|AJ302596.1|HSA302596[12054416]
    • 5938: AJ302595
      Homo sapiens 6M1-15*01 gene for olfactory receptor, cell line BM19.7
      gi|12054414|emb|AJ302595.1|HSA302595[12054414]
    • 5939: AJ302594
      Homo sapiens 6M1-15*01 gene for olfactory receptor, cell line BM28.7
      gi|12054412|emb|AJ302594.1|HSA302594[12054412]
    • 5940: AJ302593
      Homo sapiens 6M1-10*02 gene for olfactory receptor, cell line KR3598
      gi|12054410|emb|AJ302593.1|HSA302593[12054410]
    • 5941: AJ302592
      Homo sapiens 6M1-10*01 gene for olfactory receptor, cell line AMAI
      gi|12054408|emb|AJ302592.1|HSA302592[12054408]
    • 5942: AJ302591
      Homo sapiens 6M1-10*01 gene for olfactory receptor, cell line OLGA
      gi|12054406|emb|AJ302591.1|HSA302591[12054406]
    • 5943: AJ302590
      Homo sapiens 6M1-10*01 gene for olfactory receptor, cell line YAR
      gi|12054404|emb|AJ302590.1|HSA302590[12054404]
    • 5944: AJ302589
      Homo sapiens 6M1-10*01 gene for olfactory receptor, cell line SA
      gi|12054402|emb|AJ302589.1|HSA302589[12054402]
    • 5945: AJ302588
      Homo sapiens 6M-10*01 gene for olfactory receptor, cell line WT51
      gi|12054400|emb|AJ302588.1|HSA302588[12054400]
    • 5946: AJ302587
      Homo sapiens 6M1-10*01 gene for olfactory receptor, cell line H2LCL
      gi|12054398|emb|AJ302587.1|HSA302587[12054398]
    • 5947: AJ302586
      Homo sapiens 6M1-10*01 gene for olfactory receptor, cell line LG2
      gi|12054396|emb|AJ302586.1|HSA302586[12054396]
    • 5948: AJ302585
      Homo sapiens 6M1-10*01 gene for olfactory receptor, cell line BM19.7
      gi|12054394|emb|AJ302585.1|HSA302585[12054394]
    • 5949: AJ302584
      Homo sapiens 6M1-10*01 gene for olfactory receptor, cell line BM28.7
      gi|12054392|emb|AJ302584.1|HSA302584[12054392]
    • 5950: AJ302583
      Homo sapiens 6M1-6*03 gene for olfactory receptor, cell line WT51
      gi|12054390|emb|AJ302583.1|HSA302583[12054390]
    • 5951: AJ302582
      Homo sapiens 6M1-6*02 gene for olfactory receptor, cell line OLGA
      gi|12054388|emb|AJ302582.1|HSA302582[12054388]
    • 5952: AJ302581
      Homo sapiens 6M1-6*02 gene for olfactory receptor, cell line KR3598
      gi|12054386|emb|AJ3025810.1HSA302581[12054386]
    • 5953: AJ302580
      Homo sapiens 6M1-6*02 gene for olfactory receptor, cell line SA
      gi|12054384|emb|AJ302580.1|HSA302580[12054384]
    • 5954: AJ302579
      Homo sapiens 6M1-6*02 gene for olfactory receptor, cell line AMAI
      gi|12054382|emb|AJ302579.1|HSA302579[12054382]
    • 5955: AJ302578
      Homo sapiens 6M1-6*02 gene for olfactory receptor, cell line BM28.7
      gi|12054380|emb|AJ302578.1|HSA302578[12054380]
    • 5956: AJ302577
      Homo sapiens 6M1-6*02 gene for olfactory receptor, cell line BM19.7
      gi|112054378|emb|AJ302577.1|HSA302577[12054378]
    • 5957: AJ302576
      Homo sapiens 6M1-6*01 gene for olfactory receptor, cell line OLGA
      gi|12054376|emb|AJ302576.1|HSA302576[12054376]
    • 5958: AJ302575
      Homo sapiens 6M1-6*01 gene for olfactory receptor, cell line YAR
      gi|2054374|emb|AJ302575.1|HSA302575[12054374]
    • 5959: AJ302574
      Homo sapiens 6M1-6*01 gene for olfactory receptor, cell line SA
      gi|12054372|emb|AJ302574.1|HSA302574[12054372]
    • 5960: AJ302573
      Homo sapiens 6M1-6*01 gene for olfactory receptor, cell line H2LCL
      gi|12054370|emb|AJ302573.1|HSA302573[12054370]
    • 5961: AJ302572
      Homo sapiens 6M1-6*01 gene for olfactory receptor, cell line KR3598
      gi|12054368|emb|AJ302572.1|HSA302572[12054368]
    • 5962: AJ302571
      Homo sapiens 6M1-6*01 gene for olfactory receptor, cell line LG2
      gi|12054366|emb|AJ302571.1|HSA302571[12054366]
    • 5963: AJ302570
      Homo sapiens 6M1-4P*05 gene for olfactory receptor, cell line BM19.7
      gi|12054364|emb|AJ302570.1|HSA302570[12054364]
    • 5964: AJ302569
      Homo sapiens 6M1-4P*05 gene for olfactory receptor, cell line BM28.7
      gi|12054362|emb|AJ302569.1|HSA302569[12054362]
    • 5965: AJ302568
      Homo sapiens 6M1-4P*04 gene for olfactory receptor, cell line AMAI
      gi|12054360|emb|AJ302568.1|HSA302568[12054360]
    • 5966: AJ302567
      Homo sapiens 6M1-4P*03 gene for olfactory receptor, cell line WT51
      gi|12054358|emb|AJ302567.1|HSA302567[12054358]
    • 5967: AJ302566
      Homo sapiens 6M1-4P*02 gene for olfactory receptor, cell line OLGA
      gi|2054356|emb|AJ302566.1|HSA302566[12054356]
    • 5968: AJ302565
      Homo sapiens 6M1-4P*02 gene for olfactory receptor, cell line KR3598
      gi|12054354|emb|AJ302565.1|HSA302565[12054354]
    • 5975: AJ302558
      Homo sapiens 6M1-3*04 gene for olfactory receptor, cell line AMAI
      gi|12054346|emb|AJ302558.1|HSA302558[12054346]
    • 5976: AJ302557
      Homo sapiens 6M1-3*03 gene for olfactory receptor, cell line WT51
      gi|12054344|emb|AJ302557.1|HSA302557[12054344]
    • 5977: AJ302551
      Homo sapiens 6M1-3*01 gene for olfactory receptor, cell line OLGA
      gi|12054342|emb|AJ302551.1|HSA302551[12054342]
    • 5978: AJ302550
      Homo sapiens 6M1-3*01 gene for olfactory receptor, cell line YAR
      gi|12054340|emb|AJ302550.1|HSA302550[12054340]
    • 5979: AJ302549
      Homo sapiens 6M1-3*01 gene for olfactory receptor, cell line SA
      gi|12054338|emb|AJ302549.1|HSA302549[12054338]
    • 5980: AJ302548
      Homo sapiens 6M1-3*01 gene for olfactory receptor, cell line H2LCL
      gi|12054336|emb|AJ302548.1|HSA302548[12054336]
    • 5981: AJ302547
      Homo sapiens 6M1-3*01 gene for olfactory receptor, cell line LG2
      gi|2054334|emb|AJ302547.1|HSA302547[12054334]
    • 5982: AJ302546
      Homo sapiens 6M1-1*02 gene for olfactory receptor, cell line BM19.7
      gi|12054332|emb|AJ302546.1|HSA302546[12054332]
    • 5983: AJ302545
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line KR3598
      gi|12054330|emb|AJ302545.1|HSA302545[12054330]
    • 5984: AJ302544
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line YAR
      gi|12054328|emb|AJ302544.1|HSA302544[12054328]
    • 5985: AJ302543
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line OLGA
      gi|12054326|emb|AJ302543.1|HSA302543[12054326]
    • 5986: AJ302542
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line SA
      gi|12054324|emb|AJ302542.1|HSA302542[12054324]
    • 5987: AJ302541
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line AMAI
      gi|12054322|emb|AJ302541.1|HSA302541[12054322]
    • 5988: AJ302540
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line WT51
      gi|12054320|emb|AJ302540.1|HSA302540[12054320]
    • 5989: AJ302539
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line H2LCL
      gi|12054318|emb|AJ302539.1|HSA302539[12054318]
    • 5990: AJ302538
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line BM28.7
      gi|12054316|emb|AJ302538.1|HSA302538[12054316]
    • 5991: AJ302537
      Homo sapiens 6M1-1*01 gene for olfactory receptor, cell line LG2
      gi|12054314|emb|AJ302537.1|HSA302537[12054314]
    • 5993: AJ131724
      Homo sapiens mRNA for serotonin receptor 5-HT4 (splice variant h5-HT4(b))
      gi|12053629|emb|AJ131724.1|HSA131724[12053629]
    • 5994: AF305200
      Homo sapiens interleukin 17E (IL17E) mRNA, complete cds
      gi|11878209|gb|AF305200.1|AF305200[11878209]
    • 5995: AH003378
      Homo sapiens ciliary neurotrophic factor alpha receptor gene
      gi|608655|gb|AH003378.1|SEG_HUMCNFAR0[608655]
    • 5996: L38025
      Homo sapiens ciliary neurotrophic factor alpha receptor gene, exons 8-10, complete cds
      gi|608654|gb|L38025.1|HUMCNFAR06[608654]
    • 5997: L38024
      Homo sapiens ciliary neurotrophic factor alpha receptor gene, exons 5-7
      gi|608653|gb|L38024.1|HUMCNFAR05[608653]
    • 5998: L38023
      Homo sapiens ciliary neurotrophic factor alpha receptor gene, exon 4
      gi|608652|gb|L38023.1|HUMCNFAR04[608652]
    • 5999: L38022
      Homo sapiens ciliary neurotrophic factor alpha receptor gene, exon 3
      gi|608651|gb|L380220.1HUMCNFAR03[608651]
    • 6000: L38021
      Homo Sapiens ciliary neurutrophic factor alpha receptor gene, exon 2
      gi|608650|gb|L38021.1|HUMCNFAR02[608650]
    • 6001: L38020
      Homo sapiens ciliary neurotrophic factor alpha receptor gene, exon 1
      gi|608649|gb|L380200.1HUMCNFAR01[608649]
    • 6050: NM012152
      Homo sapiens endothelial differentiation, lysophosphatidic acid
      G-protein-coupled receptor, 7 (EDG7), mRNA
      gi|6912347|ref|NM012152.1|[6912347]
    • 6051: NM007360
      Homo sapiens DNA segment on chromosome 12 (unique) 2489 expressed sequence (D12S2489E), mRNA
      gi|6679051|ref|NM007360.1|[6679051]
    • 6054: AF263029
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 14
      and complete cds
      gi|12043771|gb|AF263029.1|F263016S14[12043771]
    • 6055: AF263028
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 13
      gi|12043770|gb|AF263028.1|F263016S13[12043770]
    • 6056: AF263027
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 12
      gi|12043769|gb|AF263027.1|F263016S12[12043769]
    • 6057: AF263026
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 11----
      gi|12043768|gb|AF263026.1|F263016S11[12043768]
    • 6058: AF263025
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 10
      gi|12043767|gb|AF263025.1|F263016S10[12043767]
    • 6059: AF263024
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 9
      gi|12043766|gb|AF263024.1|F263016S09[12043766]
    • 6060: AF263023
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 8
      gi|12043765|gb|AF263023.1|F263016S08[12043765]
    • 6061: AF263022
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 7
      gi|12043764|gb|AF263022.1|F263016S07[12043764]
    • 6062: AF263021
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 6
      gi|12043763|gb|AF263021.1F263016S06[12043763]
    • 6063: AF263020
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 5
      gi|12043762|gb|AF263020.1|F263016S05[12043762]
    • 6064: AF263019
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon
      gi|12043761|gb|AF263019.1|F263016S04[12043761]
    • 6065: AF263018
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 3
      gi|12043760|gb|AF263018.1|F263016S03[12043760]
    • 6066: AF263017
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 2
      gi|12043759|gb|AF263017.1|F263016S02[12043759]
    • 6067: AF263016
      Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR) gene, exon 1
      gi|12043758|gb|AF263016.1|F263016S01[12043758]
    • 6068: AH010208
      Homo sapiens chromosome 12 map 12q15
      gi|12043757|gb|AH010208.1|SEG_F263016S[12043757]
    • 6069: AF310676
      Homo sapiens E3 ubiquitin ligase SMURF2 mRNA, complete cds
      gi|112018150gb|AF310676.1|AF310676[12018150]
    • 6070: AF310250
      Homo sapiens IRS-1 PH domain binding protein PHIP mRNA, complete cds
      gi|12007333|gb|AF310250.1|AF310250[12007333]
    • 6071: AF276292
      Homo sapiens killer cell immunoglobulin-like receptor KIR2DL4 mRNA, complete cds
      gi|12006296|gb|AF276292.1|AF276292[12006296]
    • 6072: AF272157
      Homo sapiens killer cell immunoglobulin-like receptor precursor (KIR2DLX) gene,
      complete cds
      gi|12006228|gb|AF272157.1|AF272157[12006228]
    • 6073: AF271608
      Homo sapiens clone 3 killer cell immunoglobulin-like receptor KIR2DLX (KIR2DLX)
      mRNA, complete cds
      gi|12006190|gb|AF271608.1|AF271608[12006190]
    • 6074: AF271607
      Homo sapiens clone 13 killer cell immunoglobulin-like receptor KIR2DLX (KIR2DLX)
      mRNA, complete cds
      gi|2006188|gb|AF271607.1|AF271607[12006188]
    • 6075: AF223941
      Homo sapiens complement receptor 2 (CR2) gene, promoter region and partial sequence
      gi|12004993|gb|AF223941.1|AF223941[12004993]
    • 6076: AF196176
      Homo sapiens capsaicin receptor variant mRNA, complete cds
      gi|12003147|gb|AF196176.1|AF196176[12003147]
    • 6077: AF196175
      Homo sapiens capsaicin receptor mRNA, complete cds
      gi|12003145|gb|AF196175.1|AF196175[12003145]
    • 6078: AF125539
      Homo sapiens epidermal growth factor receptor (EGFR) gene, alternative exons, exons 16 and 17 and partial cds, alternatively spliced
      gi|12002219|gb|AF125539.1|AF125538S2[12002219]
    • 6079: AF125538
      Homo sapiens epidermal growth factor receptor (EGFR) gene, exon 15
      gi|2002218|gb|AF125538.1|AF125538S1[12002218]
    • 6080: AH010139
      Homo sapiens epidermal growth factor receptor (EGFR) gene, partial cds, alternatively spliced
      gi|12002217|gb|AH010139.1|SEG_AF125538S[12002217]
    • 6081: AF308571
      Homo sapiens hepatointestinal leukotriene B4 receptor mRNA, complete cds
      gi|11878227|gb|AF308571.1|AF308571[11878227]
    • 6082: AF275260
      Homo sapiens SRPSOX (SRPSOX) mRNA, complete cds
      gi|11139543|gb|AF275260.1|AF275260[11139543]
    • 6083: NM007161
      Homo sapiens DNA segment on chromosome 6 (unique) 49 expressed sequence, NK cell
      triggering receptor, p30 (D6S49E), mRNA
      gi|6005740|ref|NM007161.1|[6005740]
    • 6090: AF289204
      Homo sapiens odorant receptor HOR3′beta4 and odorant receptor HOR3′beta5 genes,
      complete cds
      gi|1991862|gb|AF289204.1|AF289203S2[11991862]
    • 6091: AF289203
      Homo sapiens odorant receptor HOR3′beta1, odorant receptor HOR3′beta2, and odorant receptor HOR3′beta3 genes, complete cds
      gi|11991861|gb|AF289203.1|AF289203S1[11991861]
    • 6092: AH010109
      Homo sapiens odorant receptor HOR3′beta1, odorant receptor HOR3′beta4, odorant
      receptor HOR3′beta2, odorant receptor HOR3′beta5, and odorant receptor HOR3′beta3 genes, complete cds
      gi|11991860|gb|AH010109.1|SEG_AF289203S[11991860]
    • 6093: AF217689
      Homo sapiens nociceptin receptor ORL1 (ORL1) gene, exons 1b and 2, and partial
      cds, alternatively spliced
      gi|11991833|gb|AF217689.1|AF217688S2[11991833]
    • 6094: AF217688
      Homo sapiens G alpha interacting protein (GAIP) gene, partial cds, alternatively
      spliced; and nociceptin receptor ORL1 (ORL1) gene, exon 1a
      gi|11991832|gb|AF217688.1|AF217688S1[11991832]
    • 6095: AH010108
      Homo sapiens G alpha interacting protein (GAIP) and nociceptin receptor ORL1 (ORL1) genes, partial cds
      gi|1199183|gb|AH010108.1|SEG_AF217688S[11991831]
    • 6096: AB045011
      Homo sapiens hmGluR2 gene for metabotropic glutamate receptor type 2, complete
      cds
      gi|11990938|dbj|AB045011.1|AB045011[11990938]
    • 6097: AF281074
      Homo sapiens neuropilin 2 (NRP2) gene, complete cds, alternatively spliced
      gi|11934947|gb|AF281074.1|AF281074[11934947]
    • 6098: AJ400846
      Homo sapiens mRNA for immunoglobulin-like cell surface receptor FDFACT1, activating counterpart allele 1
      gi|11932154|emb|AJ400846.1|HSA400846[11932154]
    • 6099: AJ400845
      Homo sapiens mRNA for immunoglobulin-like cell surface receptor FDFACT2, activating counterpart allele 2
      gi|11932151|emb|AJ400845.1|HSA400845[11932151]
    • 6100: AB024327
      Homo sapiens pt-wd mRNA for WD-40 repeat protein, complete cds
      gi|4519416|dbj|AB024327.1|AB024327[4519416]
    • 6102: AF280547
      Homo sapiens neuropilin-1 soluble isoform 11 (NRP1) mRNA, complete cds, alternatively spliced
      gi|11907931|gb|AF280547.1|AF280547[11907931]
    • 6103: AF280546
      Homo sapiens neuropilin-2 soluble isoform 9 (NRP2) mRNA, complete cds, alternatively spliced
      gi|11907929|gb|AF280546.1|AF280546[11907929]
    • 6104: AF280545
      Homo sapiens neuropilin-2b(5) (NRP2) mRNA, complete cds, alternatively spliced
      gi|11907927|gb|AF280545.1|AF280545[11907927]
    • 6105: AF280544
      Homo sapiens neuropilin-2b(O) (NRP2) mRNA, complete cds, alternatively spliced
      gi|11907925|gb|AF280544.1|AF280544[11907925]
    • 6106: AF268899
      Homo sapiens neuropeptide FF receptor 2 (NPFF2) mRNA, complete cds
      gi|11907914|gb|AF268899.1|AF268899[11907914]
    • 6107: AF268898
      Homo sapiens neuropeptide FF receptor 1 (NPFF1) mRNA, complete cds
      gi|11907912|gb|AF268898.1|AF268898[11907912]
    • 6111: Y19228
      Homo sapiens partial GIR gene for glucocorticoid induced receptor, exons and joined CDS
      gi|11878425|emb|Y19228.1|HSY19228[11878425]
    • 6118: Y19231
      Homo sapiens partial GIR gene for glucocorticoid induced receptor, exon 4
      gi|11877264|emb|Y19231.1|HSY19231[11877264]
    • 6119: Y19230
      Homo sapiens partial GIR gene for glucocorticoid induced receptor, exon 3
      gi|11877263|emb|Y19230.1|HSY19230[11877263]
    • 6120: Y19229
      Homo sapiens partial GIR gene for glucocorticoid induced receptor, exon 2
      gi|11877262|emb|Y19229.1|HSY19229[11877262]
    • 6121: AX047952
      Sequence 19 from Patent WO0070045
      gi|11876875|emb|AX047952.1|AX047952[11876875]
    • 6122: AX047940
      Sequence 7 from Patent WO0070045
      gi|11876863|emb|AX047940.1|AX047940[11876863]
    • 6123: AX047936
      Sequence 3 from Patent WO0070045
      gi|11876859|emb|AX047936.1|AX047936[11876859]
    • 6124: AJ272207
      Homo sapiens mRNA for putative G protein-coupled receptor 92 (GPR92 gene)
      gi|9843745|emb|AJ272207.1|HSA272207[9843745]
    • 6125: AF311306
      Homo sapiens prostate specific G-protein coupled receptor gene, complete cds
      gi|11875777|gb|AF311306.1|AF311306[11875777]
    • 6126: NM022146
      Homo sapiens neuropeptide FF 1; RFamide-related peptide receptor (OT7T022), mRNA
      gi|11545886|ref|NM022146.1|[11545886]
    • 6127: NM004885
      Homo sapiens neuropeptide G protein-coupled receptor; neuropeptide FF 2 (NPGPR),
      mRNA
      gi|4758819|ref|NM004885.1|[4758819]
    • 6128: NM002958
      Homo sapiens RYK receptor-like tyrosine kinase (RYK), mRNA
      gi|11863158|ref|NM002958.1|[11863158]
    • 6129: AF217485
      Homo sapiens KIR3D51 gene, partial sequence; and killer cell Ig-like receptor KIR2DL5.1 (KIR2DL5.1) gene, complete cds
      gi|1761705|gb|AF217485.1|AF217485[11761705]
    • 6130: NM005856
      Homo sapiens receptor (calcitonin) activity modifying protein 3 (RAMP3), mRNA
      gi|5032022|ref|NM005856.1|[5032022]
    • 6131: NM005854
      Homo sapiens receptor (calcitonin) activity modifying protein 2 (RAMP2), mRNA
      gi|5032020|ref|NM005854.1|[5032020]
    • 6132: NM005855
      Homo sapiens receptor (calcitonin) activity modifying protein 1 (RAMP1), mRNA
      gi|5032018|ref|NM005855.1|[5032018]
    • 6133: NM000025
      Homo sapiens adrenergic, beta-3-, receptor (ADRB3), mRNA
      gi|4557266|ref|NM000025.1|[4557266]
    • 6134: AF245390
      Homo sapiens GREB1c (GREB1) mRNA, complete cds, alternatively spliced
      gi|11611737|gb|AF245390.1|AF245390[11611737]
    • 6135: AF245389
      Homo sapiens GREB1b (GREB1) mRNA, complete cds, alternatively spliced
      gi|11611735|gb|AF245389.1|AF245389[11611735]
    • 6136: AF245388
      Homo sapiens GREB1a (GREB1) mRNA, partial cds, alternatively spliced
      gi|11611733|gb|AF245388.1|AF245388[11611733]
    • 6137: AF292402
      Homo sapiens neuromedin U receptor-type 2 mRNA, complete cds
      gi|9944989|gb|AF292402.1|AF292402[9944989]
    • 6138: NM002855
      Homo sapiens poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin) (PVRL1), mRNA
      gi|11602905|ref|NM002855.2|[11602905]
    • 6143: AH010043
      Homo sapiens
      gi|1155957|gb|AH010043.1|SEG_AF260138S[11559571]
    • 6144: AF260137
      Homo sapiens killer-cell immunoglobulin-like receptor KIR2DL5.3 (KIR2DL5) gene,
      exon 1 and partial cds
      gi|11559569|gb|AF260137.1|AF260137[11559569]
    • 6145: X76400
      Homo sapiens mRNA for nectin 1 (PRR1 gene)
      gi|11558774|emb|X76400.2|HSPRR[11558774]
    • 6147: NM022159
      Homo sapiens ETL protein (ETL), mRNA
      gi|11545907|ref|NM022159.1|[11545907]
    • 6148: NM022150
      Homo sapiens RFamide-related peptide precursor (RFRP), mRNA
      gi|11545893|ref|NM022150.1|[11545893]
    • 6149: NM022049
      Homo sapiens G-protein coupled receptor 88 (GPR88), mRNA
      gi|11545752|ref|NM022049.1|[11545752]
    • 6219: AF281308
      Homo sapiens alpha 2A adrenergic receptor (ADRA2A) gene, complete cds
      gi|9652209|gb|AF281308.1|AF281308[9652209]
    • 6241: AF217487
      Homo sapiens killer cell Ig-like receptor KIR2DL5.3 (KIR2DL5.3) mRNA, complete
      cds
      gi|11528059|gb|AF217487.1|AF217487[11528059]
    • 6242: NM003553
      Homo sapiens olfactory receptor, family 1, subfamily E, member 1 (OR1E1), mRNA
      gi|11496274|ref|NM003553.1|[11496274]
    • 6243: AF208054
      Homo sapiens non-inhibitory killer-cell Ig-like receptor KIR (KIR2D55) mRNA, complete cds
      gi|11493968|gb|AF208054.1|AF208054[11493968]
    • 6244: NM018690
      Homo sapiens apolipoprotein B48 receptor (APOB48R), mRNA
      gi|8922078|ref|NM018690.1|[8922078]
    • 6245: AB044934
      Homo sapiens H4R mRNA for histamine H4 receptor, complete cds
      gi|10241846|dbj|AB044934.1|AB044934[10241846]
    • 6246: NM003555
      Homo sapiens olfactory receptor, family 1, subfamily G, member 1 (OR1G1), mRNA
      gi|11415033|ref|NM003555.1|[11415033]
    • 6247: NM003552
      Homo sapiens olfactory receptor, family 1, subfamily D, member 4 (OR1D4), mRNA
      gi|11415031|ref|NM003552.1|[11415031]
    • 6248: NM003554
      Homo sapiens olfactory receptor, family 1, subfamily E, member 2 (OR1E2), mRNA
      gi|11386152|ref|NM003554.1|[11386152]
    • 6390: AF264014
      Homo sapiens scavenger receptor cysteine-rich type 1 protein M160 precursor, mRNA, complete cds, alternatively spliced
      gi|9652086|gb|AF264014.1|AF264014[9652086]
    • 6391: AF169007
      Homo sapiens beta-1-adrenergic receptor (ADRB1) gene, complete cds
      gi|5833816|gb|AF169007.1|AF169007[5833816]
    • 6392: AF169006
      Homo sapiens beta-1-adrenergic receptor (ADRB1) gene, complete cds
      gi|5833814|gb|AF169006.1|AF169006[5833814]
    • 6393: AF159854
      Homo sapiens cytokine signaling suppressor (SOCS3) mRNA, complete cds
      gi|5353755|gb|AF159854.1|AF159854[5353755]
    • 6394: AF032124
      Homo sapiens RET proto-oncogene (RET) gene, 5′ flanking region and partial cds
      gi|2795879|gb|AF032124.1|AF032124[2795879]
    • 6395: NM002644
      Homo sapiens polymeric immunoglobulin receptor (PIGR), mRNA
      gi|11342673|ref|NM002644.1|[11342673]
    • 6396: AJ249248
      Homo sapiens mRNA for putative G protein-coupled Receptor
      gi|5834594|emb|AJ249248.1|HSA249248[5834594]
    • 6397: AJ277028
      Homo sapiens mRNA for vanilloid receptor 1 (VR1 gene)
      gi|8977865|emb|AJ277028.1|HSA277028[8977865]
    • 6398: AF072872
      Homo sapiens frizzled 1 mRNA, complete cds
      gi|5305406|gb|AF072872.1|AF072872[5305406]
    • 6399: AF073727
      Homo sapiens EH domain-binding mitotic phosphoprotein (EPSIN) mRNA, complete cds
      gi|5051635|gb|AF073727.1|AF073727[5051635]
    • 6400: NM002551
      Homo sapiens olfactory receptor, family 3, subfamily A, member 2 (OR3A2), mRNA
      gi|11321568|ref|NM002551.1|[11321568]
    • 6401: NM000870
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 4 (HTR4), mRNA
      gi|11321562|ref|NM000870.1|[11321562]
    • 6419: AB042411
      Homo sapiens strg gene for striatum-specific G potein-coupled receptor, complete
      cds
      gi|11275369|dbj|AB042411.1|AB042411[11275369]
    • 6420: AB042410
      Homo sapiens strg mRNA for striatum-specific G protein-coupled receptor, complete cds
      gi|1275367|dbj|AB042410.1|AB042410[11275367]
    • 6434: AJ289159
      Homo sapiens CD30 gene for cytokine receptor CD30, exons 1-8
      gi|11230634|emb|AJ289159.1|HSA289159[11230634]
    • 6435: AF279762
      Homo sapiens ROR2 (ROR2) gene, exon 9 and partial cds
      gi|11228720|gb|AF279762.1|AF279755S8[11228720]
    • 6436: AF279761
      Homo sapiens ROR2 (ROR2) gene, exon 8
      gi|11228719|gb|AF279761.1|AF279755S7[11228719]
    • 6437: AF279760
      Homo sapiens ROR2 (ROR2) gene, exon 7
      gi|11228718|gb|AF279760.1|AF279755S6[11228718]
    • 6438: AF279759
      Homo sapiens ROR2 (ROR2) gene, exon 6
      gi|11228717|gb|AF279759.1|AF279755S5[11228717]
    • 6439: AF279758
      Homo sapiens ROR2 (ROR2) gene, exon 5
      gi|11228716|gb|AF279758.1|AF279755S4[11228716]
    • 6440: AF279757
      Homo sapiens ROR2 (ROR2) gene, exon 4
      gi|11228715|gb|AF279757.1|AF279755S3[11228715]
    • 6441: AF279756
      Homo sapiens ROR2 (ROR2) gene, exon 3
      gi|11228714|gb|AF279756.1|AF279755S2[11228714]
    • 6442: AF279755
      Homo sapiens ROR2 (ROR2) gene, exon 2
      gi|11228713|gb|AF279755.1|AF279755S1[11228713]
    • 6443: AH010002
      Homo sapiens ROR2 (ROR2) gene, partial cds
      gi|11228712|gb|AH010002.1|SEG AF279755S[11228712]
    • 6444: AF260529
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 19 and partial cds
      gi|11228705|gb|AF260529.1|F260514S16[11228705]
    • 6445: AF260528
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exons 17 and 18
      gi|11228704|gb|AF260528.1|F260514S15[11228704]
    • 6446: AF260527
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 16
      gi|11228703|gb|AF260527.1|F260514S14[11228703]
    • 6447: AF260526
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 15
      gi|11228702|gb|AF260526.1|F260514S13[11228702]
    • 6448: AF260525
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 14
      gi|11228701|gb|AF260525.1|F260514S12[11228701]
    • 6449: AF260524
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exons 12 and 13
      gi|11228700|gb|AF260524.1|F260514S11[11228700]
    • 6450: AF260523
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 11
      gi|11228699|gb|AF260523.1|F260514S10[11228699]
    • 6451: AF260522
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 10
      gi|11228698|gb|AF260522.1|F260514S09[11228698]
    • 6452: AF260521
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 9
    • 6453: AF260520
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 8
      gi|11228696|gb|AF260520.1|F260514S07[11228696]
    • 6454: AF260519
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 7
      gi|11228695|gb|AF260519.1|F260514S06[11228695]
    • 6455: AF260518
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 6
      gi|11228694|gb|AF260518.1|F260514S05[11228694]
    • 6456: AF260517
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 5
      gi|11228693|gb|AF260517.1|F260514S04[11228693]
    • 6457: AF260516
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 4
      gi|11228692|gb|AF260516.1|F260514S03[11228692]
    • 6458: AF260515
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 3
      gi|11228691|gb|AF260515.1|F260514S02[11228691]
    • 6459: AF260514
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, exon 2
      gi|11228690|gb|AF260514.1|F260514S01[11228690]
    • 6460: AH010001
      Homo sapiens MER receptor tyrosine kinase (MERTK) gene, partial cds
      gi|11228689|gb|AH010001.1|SEG_F260514S[11228689]
    • 6461: AF175406
      Homo sapiens transient receptor potential 4 (TRP4) mRNA, complete cds
      gi|5802614|gb|AF175406.1|AF175406[5802614]
    • 6462: NM017416
      Homo sapiens interleukin 1 receptor accessory protein-like 2 (IL1RAPL2), mRNA
      gi|11225606|ref|NM017416.1|[11225606]
    • 6463: AJ295237
      Homo sapiens mRNA for neuronal nicotinic acetylcholine receptor subunit alpha 10
      (NACHR alpha 10 gene)
      gi|11182127|emb|AJ295237.1|HSA295237[11182127]
    • 6464: NM004720
      Homo sapiens endothelial differentiation, lysophosphatidic acid
      G-protein-coupled receptor, 4 (EDG4), mRNA
      gi|11038657|ref|NM004720.3|[11038657]
    • 6465: AF298770
      Homo sapiens Smac/DIABLO-S protein mRNA, complete cds
      gi|107196531|gb|AF298770.1|AF298770[10719653]
    • 6562: NM005226
      Homo sapiens endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 (EDG3), mRNA
      gi|4885194|ref|NM005226.1|[4885194]
    • 6563: NM021803
      Homo sapiens interleukin 21 (IL21), mRNA
      gi|11141874|ref|NM021803.1|[11141874]
    • 6564: NM021798
      Homo sapiens interleukin 21 receptor (IL21R), mRNA
      gi|11141868|ref|NM021798.1|[11141868]
    • 6565: AF307973
      Homo sapiens histamine H4 receptor mRNA, complete cds
      gi|11141732|gb|AF307973.1|AF307973[11141732]
    • 6566: X06026
      Homo sapiens partial CD3G gene, exon 1 (and joined CDS)
      gi|36809|emb|X06026.1|HSTCR3G1[36809]
    • 6567: AF200220
      Homo sapiens FcRn alpha chain (FCGRT) gene, exons 5, 6, 7, and complete cds
      gi|11138512|gb|AF200220.1|AF200219S2[11138512]
    • 6568: AF200219
      Homo sapiens FcRn alpha chain (FCGRT) gene, exons 1 through 4
      gi|11138511|gb|AF200219.1|AF200219S1[1113851l]
    • 6569: AH009974
      Homo sapiens FcRn alpha chain (FCGRT) gene, exons 1 through 4
      gi|11138510|gb|AH009974.1|SEG_AF200219S[11138510]
    • 6570: NM017581
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 9 (CHRNA9), mRNA
      gi|8923741|ref|NM017581.1|[8923741]
    • 6571: AB040290
      Homo sapiens RFRP mRNA for RFamide-related peptide precursor, complete cds
      gi|11125707|dbj|AB040290.1|AB040290[11125707]
    • 6572: AB040104
      Homo sapiens OT7T022 mRNA for RFamide-related peptide receptor, complete cds
      gi|11125701|dbj|AB040104.1|AB040104[11125701]
    • 6598: AF308542
      Homo sapiens clone ST1L_G11 immunoglobulin heavy chain mRNA, partial cds
      gi|11119124|gb|AF308542.1|AF308542[11119124]
    • 6599: AJ271338
      Homo sapiens IL1L1 gene for interleukin-1 like protein 1, exons 1-6
      gi|6729586|emb|AJ271338.1|HSA271338[6729586]
    • 6600: AJ242738
      Homo sapiens mRNA for interleukin-1-like protein 1 (IL1L1 gene) transcript 2
      gi|6165335|emb|AJ242738.1|HSA242738[6165335]
    • 6601: AJ242737
      Homo sapiens mRNA for interleukin-1-like protein-1 (IL1L gene), transcript 1
      gi|6165333|emb|AJ242737.1|HSA242737[6165333]
    • 6602: NM005508
      Homo sapiens chemokine (C-C motif) receptor 4 (CCR4), mRNA
      gi|5031626|ref|NM005508.1|[5031626]
    • 6603: NM005283
      Homo sapiens chemokine (C motif) XC receptor 1 (CCXCR1), mRNA
      gi|4885338|ref|NM005283.1|[4885338]
    • 6604: AJ238419
      Homo sapiens mRNA for HIV-specific T-cell receptor beta chain, clone R1, partial
      gi|4691321|emb|AJ238419.1|HSA238419[4691321]
    • 6605: AJ238418
      Homo sapiens mRNA for HIV-specific T-cell receptor beta chain, clone MA, partial
      gi|4691319|emb|AJ238418.1|HSA238418[4691319]
    • 6606: AJ238417
      Homo sapiens mRNA for HIV-specific T-cell receptor beta chain, clone HA, partial
      gi|4691317|emb|AJ238417.1|HSA238417[4691317]
    • 6607: AJ238416
      Homo sapiens mRNA for HIV-specific T-cell receptor alpha chain, clone R1, partial
      gi|4691315|emb|AJ238416.1|HSA238416[4691315]
    • 6608: AJ238415
      Homo sapiens mRNA for HIV-specific T-cell receptor alpha chain, clone MA, partial
      gi|4691313|emb|AJ238415.1|HSA238415[4691313]
    • 6609: AJ238414
      Homo sapiens mRNA for HIV-specific T-cell receptor alpha chain, clone HA, partial
      gi|4691311|emb|AJ238414.1|HSA238414[4691311]
    • 6610: AF074042
      AF074042 Human Homo sapiens genomic clone pTWB15.69 T7, genomic survey sequence
      gi|3342086|gb|AF074042.1|AF074042[3342086]
    • 6611: AF074041
      AF074041 Human Homo sapiens genomic clone pTWB15.69 SP6, genomic survey sequence
      gi|3342085|gb|AF074041.1|AF074041[3342085]
    • 6612: AF074040
      AF074040 Human Homo sapiens genomic clone pTWB15.53 T7, genomic survey sequence
      gi|3342084|gb|AF074040.1|AF074040[3342084]
    • 6613: AF074039
      AF074039 Human Homo sapiens genomic clone pTWB15.53 SP6, genomic survey sequence
      gi|3342083|gb|AF074039.1|AF074039[3342083]
    • 6614: AF074038
      AF074038 Human Homo sapiens genomic clone pTWB15.43 T7, genomic survey sequence
      gi|3342082|gb|AF074038.1|AF074038[3342082]
    • 6615: AF074037
      AF074037 Human Homo sapiens genomic clone pTWB15.43 SP6, genomic survey sequence
      gi|3342081|gb|AF074037.1|AF074037[3342081]
    • 6616: AF074036
      AF074036 Human Homo sapiens genomic clone pTWB15.42, genomic survey sequence
      gi|3342080|gb|AF074036.1|AF074036[3342080]
    • 6617: AF074034
      AF074034 Human Homo sapiens genomic clone pTWB15.32 T7, genomic survey sequence
      gi|3342079|gb|AF074034.1|AF074034[3342079]
    • 6618: AF074033
      AF074033 Human Homo sapiens genomic clone pTWB15.32 SP6, genomic survey sequence
      gi|3342078|gb|AF074033.1|AF074033[3342078]
    • 6619: AF074032
      AF074032 Human Homo sapiens genomic clone pTWB15.31 T7, genomic survey sequence
      gi|3342077|gb|AF074032.1|AF074032[3342077]
    • 6620: AF074031
      AF074031 Human Homo sapiens genomic clone pTWB15.31 SP6, genomic survey sequence
      gi|3342076|gb|AF074031.1|AF074031[3342076]
    • 6621: AF074030
      AF074030 Human Homo sapiens genomic clone pTWB15.28 T7, genomic survey sequence
      gi|3342075|gb|AF074030.1|AF074030[3342075]
    • 6622: AF074028
      AF074028 Human Homo sapiens genomic clone pTWB15.21, genomic survey sequence
      gi|3342074|gb|AF074028.1|AF074028[3342074]
    • 6623: AF074027
      AF074027 Human Homo sapiens genomic clone pTWB15.12, genomic survey sequence
      gi|3342073|gb|AF074027.1|AF074027[3342073]
    • 6624: AF074026
      AF074026 Human Homo sapiens genomic clone pTWB15.09, genomic survey sequence
      gi|3342072|gb|AF074026.1|AF074026[3342072]
    • 6625: AF074025
      AF074025 Human Homo sapiens genomic clone pTWB15.08, genomic survey sequence
      gi|3342071|gb|AF074025.1|AF074025[3342071]
    • 6626: AF074024
      AF074024 Human Homo sapiens genomic clone pTWB15.07, genomic survey sequence
      gi|3342070|gb|AF074024.1|AF074024[3342070]
    • 6627: AF074023
      AF074023 Human Homo sapiens genomic clone pTWB15.04, genomic survey sequence
      gi|3342069|gb|AF074023.1|AF074023[3342069]
    • 6628: AF074022
      AF074022 Human Homo sapiens genomic clone pTWB15.04 SP6, genomic survey sequence
      gi|3342068|gb|AF074022.1|AF074022[3342068]
    • 6629: NM000450
      Homo sapiens selectin E (endothelial adhesion molecule 1) (SELE), mRNA
      gi|4506870|ref|NM000450.1|[4506870]
    • 6630: AF254069
      Homo sapiens interleukin 21 (IL21) mRNA, complete cds
      gi|11093535|gb|AF254069.1|AF254069[11093535]
    • 6631: AF254067
      Homo sapiens interleukin 21 receptor (IL21R) mRNA, complete cds
      gi|1093531|gb|AF254067.1|AF254067[11093531]
    • 6632: AF251510
      Homo sapiens leukocyte-associated Ig-like receptor 1D isoform mRNA, complete cds
      gi|1090865|gb|AF251510.2|AF251510[11090865]
    • 6633: AF251509
      Homo sapiens leukocyte-associated Ig-like receptor 1C isoform mRNA, complete cds
      gi|11090859|gb|AF251509.2|AF251509[11090859]
    • 6634: AB3043943
      Homo sapiens GPVI gene for platelet glycoprotein VI, partial cds
      gi|9955915|dbj|AB043943.1|AB043943[9955915]
    • 6635: AB043821
      Homo sapiens GPVI mRNA for platelet glycoprotein VI-3, complete cds
      gi|9955913|dbj|AB3043821.1|AB043821[9955913]
    • 6636: AB043820
      Homo sapiens GPVI mRNA for platelet glycoprotein VI-2, complete cds
      gi|9955911|dbj|AB043820.1|AB043820[9955911]
    • 6637: AB043819
      Homo sapiens GPVI mRNA for platelet glycoprotein VI-1, complete cds
      gi|9955909|dbj|AB043819.1|AB043819[9955909]
    • 6638: NM000527
      Homo sapiens low density lipoprotein receptor (familial hypercholesterolemia) (LDLR), mRNA
      gi|8051613|ref|NM000527.2|[8051613]
    • 6639: NM012407
      Homo sapiens protein kinase C, alpha binding protein (PRKCABP), mRNA
      gi|7110696|ref|NM012407.1|[7110696]
    • 6640: NM005232
      Homo sapiens EphA1 (EPHA1), mRNA
      gi|4885208|ref|NM005232.1|[4885208]
    • 6641: NM000214
      Homo sapiens jagged 1 (Alagille syndrome) (JAG1), mRNA
      gi|4557678|ref|NM000214.1|[4557678]
    • 6642: NM000875
      Homo sapiens insulin-like growth factor 1 receptor (IGF1R), mRNA
      gi|11068002|ref|NM000875.2|[11068002]
    • 6643: AF298812
      Homo sapiens X-linked ectodysplasin-A2 receptor (XEDAR) mRNA, complete cds
      gi|11066914|gb|AF298812.1|AF298812[11066914]
    • 6644: AF197929
      Homo sapiens short form lysophosphatidic acid receptor EDG4 (EDG4) mRNA, complete cds
      gi|11066253|gb|AF197929.1|AF197929[11066253]
    • 6645: NM021642
      Homo sapiens Fc fragment of IgG, low affinity IIa, receptor for (CD32) (FCGR2A),
      mRNA
      gi|11056051|ref|NM021642.1|[11056051]
    • 6646: AF280400
      Homo sapiens alpha 2C adrenergic receptor variant (ADRA2C) gene, complete cds
      gi|11055420|gb|AF280400.1|AF280400[11055420]
    • 6647: AF280399
      Homo sapiens alpha 2C adrenergic receptor (ADRA2C) gene, complete cds
      gi|11055418|gb|AF280399.1|AF280399[11055418]
    • 6648: AF263523
      Homo sapiens vanilloid receptor-related osmotically activated channel (VROAC) mRNA, complete cds
      gi|11055321|gb|AF263523.1|AF263523[11055321]
    • 6649: NM001117
      Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) (ADCYAP1),
      mRNA
      gi|10947062|ref|NM001117.2|[10947062]
    • 6650: NM002355
      Homo sapiens mannose-6-phosphate receptor (cation dependent) (M6PR), mRNA
      gi|10947032|ref|NM002355.2|[10947032]
    • 6651: NM000541
      Homo sapiens S-antigen; retina and pineal gland (arrestin) (SAG), mRNA
      gi|10880124|ref|NM000541.2|[10880124]
    • 6652: NM021130
      Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA), mRNA
      gi|10863926|ref|NM021130.1|[10863926]
    • 6653: NM001106
      Homo sapiens activin A receptor, type IIB (ACVR2B), mRNA
      gi|10862697|ref|NM001106.2|[10862697]
    • 6654: NM001616
      Homo sapiens activin A receptor, type II (ACVR2), mRNA
      gi|10862696|ref|NM001616.2|[10862696]
    • 6655: NM001105
      Homo sapiens activin A receptor, type I (ACVR1), mRNA
      gi|10862690|ref|NM001105.2|[10862690]
    • 6656: NM001136
      Homo sapiens advanced glycosylation end product-specific receptor (AGER), mRNA
      gi|10835202|ref|NM001136.1|[10835202]
    • 6657: NM000866
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1F (HTR1F), mRNA
      gi|10835196|ref|NM000866.1|[10835196]
    • 6658: NM000629
      Homo sapiens interferon (alpha, beta and omega) receptor 1 (IFNAR1), mRNA
      gi|10835182|ref|NM000629.1|[10835182]
    • 6659: NM000621
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A), mRNA
      gi|10835174|ref|NM000621.1|[10835174]
    • 6660: NM000610
      Homo sapiens CD44 antigen (homing function and Indian blood group system) (CD44), mRNA
      gi|10835162|ref|NM000610.1|[10835162]
    • 6661: NM000585
      Homo sapiens interleukin 15 (IL15), mRNA
      gi|10835152|ref|NM000585.1|[10835152]
    • 6662: NM000586
      Homo sapiens interleukin 2 (IL2), mRNA
      gi|10835148|ref|NM000586.1|[10835148]
    • 6663: NM000577
      Homo sapiens interleukin 1 receptor antagonist (IL1RN), mRNA
      gi|10835146|ref|NM000577.1|[10835146]
    • 6664: NM000576
      Homo sapiens interleukin 1, beta (IL1B), mRNA
      gi|10835144|ref|NM000576.1|[10835144]
    • 6665: NM000570
      Homo sapiens Fc fragment of IgG, low affinity 111b, receptor for (CD16) (FCGR3B), mRNA
      gi|10835138|ref|NM000570.1|[10835138]
    • 6666: NM000566
      Homo sapiens Fc fragment of IgG, high affinity Ia, receptor for (CD64) (FCGR1A),
      mRNA
      gi|10835132|ref|NM000566.1|[10835132]
    • 6667: NM000564
      Homo sapiens interleukin 5 receptor, alpha (IL5RA), mRNA
      gi|10835130|ref|NM000564.1|[10835130]
    • 6668: NM000525
      Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11
      gi|10835116|ref|NM000525.1|[10835116]
    • 6669: NM003841
      Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C), mRNA
      gi|10835042|ref|NM003841.1|[10835042]
    • 6672: NM001307
      Homo sapiens claudin 7 (CLDN7), mRNA
      gi|10835007|ref|NM001307.1[10835007]
    • 6673: NM000640
      Homo sapiens interleukin 13 receptor, alpha 2 (IL13RA2), mRNA
      gi|10834991|ref|NM000640.1|[10834991]
    • 6674: NM001993
      Homo sapiens coagulation factor III (thromboplastin, tissue factor) (F3), mRNA
      gi|10518499|ref|NM001993.2|[10518499]
    • 6675: NM013252
      Homo sapiens C-type (calcium dependent, carbohydrate-recognition domain) lectin,
      superfamily member 5 (CLECSF5), mRNA
      gi|10281668|ref|NM013252.1|[10281668]
    • 6676: NM020547
      Homo sapiens anti-Mullerian hormone receptor, type II (AMHR2), mRNA
      gi|10198655|ref|NM020547.1|[10198655]
    • 6677: NM018970
      Homo sapiens G protein-coupled receptor 85 (GPR85), mRNA
      gi|10190654|ref|NM018970.2|[10190654]
    • 6678: NM014292
      Homo sapiens chromobox homolog 6 (CBX6), mRNA
      gi|10140848|ref|NM014292.1|[10140848]
    • 6679: NM019897
      Homo sapiens olfactory receptor, family 2, subfamily S, member 2 (OR2S2), mRNA
      gi|10092668|ref|NM019897.1|[10092668]
    • 6680: NM014499
      Homo sapiens putative purinergic receptor (P2Y10), mRNA
      gi|10092632|ref|NM014499.1|[10092632]
    • 6681: NM017572
      Homo sapiens G protein-coupled receptor kinase 7 (GPRK7), mRNA
      gi|9994196|ref|NM017572.1|[9994196]
    • 6682: NM020406
      Homo sapiens polycythemia rubra vera 1; cell surface receptor (PRV1), mRNA
      gi|9966888|ref|NM020406.1|[9966888]
    • 6683: NM020377
      Homo sapiens cysteinyl leukotriene CysLT2 receptor; cDNA: PSEC0146 from clone PLACE1006979 (LOC57105), mRNA
      gi|9966850|ref|NM020377.1|[9966850]
    • 6686: NM002295
      Homo sapiens laminin receptor 1 (67 kD, ribosomal protein SA) (LAMR1), mRNA
      gi|9845501|ref|NM002295.2|[9845501]
    • 6687: NM019839
      Homo sapiens seven transmembrane receptor BLTR2; leukotriene B4 receptor BLT2 (BLTR2), mRNA
      gi|9789896|ref|NM019839.1|[9789896]
    • 6688: NM018969
      Homo sapiens super conserved receptor expressed in brain 3 (SREB3), mRNA
      gi|9507142|ref|NM018969.1|[9507142]
    • 6689: NM018949
      Homo sapiens G protein-coupled receptor 14 (GPR14), mRNA
      gi|9506744|ref|NM018949.1|[9506744]
    • 6690: NM000804
      Homo sapiens folate receptor 3 (gamma) (FOLR3), mRNA
      gi|9257219|ref|NM000804.2|[9257219]
    • 6691: NM000803
      Homo sapiens folate receptor 2 (fetal) (FOLR2), mRNA
      gi|9257218|ref|NM000803.2|[9257218]
    • 6692: NM017526
      Homo sapiens leptin receptor gene-related protein (HSOBRGRP), mRNA
      gi|8923784|ref|NM017526.1|[8923784]
    • 6693: NM017532
      Homo sapiens p65 protein (HSAJ2425), mRNA
      gi|8923776|ref|NM017532.1|[8923776]
    • 6694: NM017442
      Homo sapiens toll-like receptor 9 (TLR9), mRNA
      gi|8394455|ref|NM017442.1|[8394455]
    • 6695: NM016946
      Homo sapiens junctional adhesion molecule (JAM), mRNA
      gi|8393637|ref|NM016946.1|[8393637]
    • 6697: NM013280
      Homo sapiens fibronectin leucine rich transmembrane protein 1 (FLRT1), mRNA
      gi|8051591|ref|NM013280.2|[8051591]
    • 6698: NM013431
      Homo sapiens killer cell lectin-like receptor subfamily C, member 4 (KLRC4), mRNA
      gi|7710123|ref|NM013431.1|[7710123]
    • 6699: NM016568
      Homo sapiens G-protein coupled receptor SALPR; somatostatin and angiotensin-like
      peptide receptor (LOC51289), mRNA
      gi|7706102|ref|NM016568.1|[7706102]
    • 6700: NM015863
      Homo sapiens surfactant protein B (LOC51041), mRNA
      gi|7705659|ref|NM015863.1|[7705659]
    • 6702: NM015868
      Homo sapiens NK-receptor (KIR-023 GB), mRNA
      gi|7705567|ref|NM015868.1|[7705567]
    • 6703: NM016540
      Homo sapiens G protein-coupled receptor 72 (GPR72), mRNA
      gi|7705384|ref|NM016540.1|[7705384]
    • 6704: NM001059
      Homo sapiens tachykinin receptor 3 (TACR3), mRNA
      gi|7669547|ref|NM001059.1|[7669547]
    • 6705: NM014030
      Homo sapiens G protein-coupled receptor kinase-interactor 1 (GIT1), mRNA
      gi|7661711|ref|NM014030.1|[7661711]
    • 6706: NM014521
      Homo sapiens SH3-domain binding protein 4 (SH3BP4), mRNA
      gi|7657561|ref|NM014521.1|[7657561]
    • 6707: NM014285
      Homo sapiens homolog of Yeast RRP4 (ribosomal RNA processing 4), 3′-5′-exoribonuclease (RRP4), mRNA
      gi|7657527|ref|NM014285.1|[7657527]
    • 6708: NM014566
      Homo sapiens olfactory receptor, family 1, subfamily D, member 5 (OR1D5), mRNA
      gi|7657422|ref|NM014566.1|[7657422]
    • 6709: NM014565
      Homo sapiens olfactory receptor, family 1, subfamily A, member 1 (OR1A1), mRNA
      gi|7657420|ref|NM014565.1|[7657420]
    • 6710: NM014221
      Homo sapiens mature T-cell proliferation 1 (MTCP1), mRNA
      gi|7657348|ref|NM014221.1|[7657348]
    • 6711: NM014387
      Homo sapiens linker for activation of T cells (LAT), mRNA
      gi|7657292|ref|NM014387.1|[7657292]
    • 6712: NM014514
      Homo sapiens killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 (KIR3D51), mRNA
      gi|7657280|ref|NM014514.1|[7657280]
    • 6713: NM014513
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 (KIR2D55), mRNA
      gi|7657278|ref|NM014513.1|[7657278]
    • 6714: NM014512
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 (KIR2D51), mRNA
      gi|7657276|ref|NM014512.1|[7657276]
    • 6715: NM014511
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 (KIR2DL3), mRNA
      gi|7657274|ref|NM014511.1|[7657274]
    • 6716: NM014219
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 (KIR2DL2), mRNA
      gi|7657272|ref|NM014219.1|[7657272]
    • 6717: NM014218
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 (KIR2DL1), mRNA
      gi|7657270|ref|NM014218.1|[7657270]
    • 6718: NM014271
      Homo sapiens interleukin 1 receptor accessory protein-like 1 (IL1RAPL1), mRNA
      gi|7657231|ref|NM014271.1|[7657231]
    • 6719: NM014339
      Homo sapiens interleukin 17 receptor (IL17R), mRNA
      gi|7657229|ref|NM014339.1|[7657229]
    • 6720: NM014619
      Homo sapiens glutamate receptor, ionotropic, kainate 4 (GRIK4), mRNA
      gi|7657143|ref|NM014619.1|[7657143]
    • 6721: NM014626
      Homo sapiens G protein-coupled receptor 58 (GPR58), mRNA
      gi|7657141|ref|NM014626.1|[7657141]
    • 6722: NM014627
      Homo sapiens G protein-coupled receptor 57 (GPR57), mRNA
      gi|7657139|ref|NM014627.1|[7657139]
    • 6723: NM014373
      Homo sapiens putative G protein-coupled receptor (GPCR150), mRNA
      gi|7657135|ref|NM014373.1|[7657135]
    • 6724: NM005529
      Homo sapiens heparan sulfate proteoglycan 2 (perlecan) (HSPG2), mRNA
      gi|7427516|ref|NM005529.2|[7427516]
    • 6727: NM005415
      Homo sapiens solute carrier family 20 (phosphate transporter), member 1 (SLC20A1), mRNA
      gi|7382462|ref|NM005415.2|[7382462]
    • 6728: NM005199
      Homo sapiens cholinergic receptor, nicotinic, gamma polypeptide (CHRNG), mRNA
      gi|7382453|ref|NM005199.3|[7382453]
    • 6729: NM013940
      Homo sapiens olfactory receptor, family 10, subfamily H, member 1 (OR10H1), mRNA
      gi|7363438|ref|NM013940.1|[7363438]
    • 6730: NM013440
      Homo sapiens paired immunoglobulin-like receptor beta (PILR(BETA)), mRNA
      gi|7305386|ref|NM013440.1|[7305386]
    • 6731: NM013439
      Homo sapiens paired immunoglobulin-like receptor alpha (PILR(ALPHA)), mRNA
      gi|7305384|ref|NM013439.1|[7305384]
    • 6732: NM002260
      Homo sapiens killer cell lectin-like receptor subfamily C, member 2 (KLRC2), mRNA
      gi|7108353|ref|NM002260.2|[7108353]
    • 6733: NM012125
      Homo sapiens cholinergic receptor, muscarinic 5 (CHRM5), mRNA
      gi|7108335|ref|NM012125.1|[7108335]
    • 6734: NM013378
      Homo sapiens pre-B lymphocyte gene 3 (VPREB3), mRNA
      gi|7019566|ref|NM013378.1|[7019566]
    • 6735: NM013261
      Homo sapiens peroxisome proliferative activated receptor, gamma, coactivator (PPARGC1), mRNA
      gi|7019498|ref|NM013261.1|[7019498]
    • 6736: NM013269
      Homo sapiens lectin-like NK cell receptor (LLT1), mRNA
      gi|7019446|ref|NM013269.1|[7019446]
    • 6737: NM013289
      Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (KIR3DL1), mRNA
      gi|7019440|ref|NM013289.1|[7019440]
    • 6738: NM013281
      Homo sapiens fibronectin leucine rich transmembrane protein 3 (FLRT3), mRNA
      gi|7019382|ref|NM013281.1|[7019382]
    • 6739: NM013231
      Homo sapiens fibronectin leucine rich transmembrane protein 2 (FLRT2), mRNA
      gi|7019380|ref|NM013231.1|[7019380]
    • 6740: NM012410
      Homo sapiens type I transmembrane receptor (seizure-related protein) (PSK-1), mRNA
      gi|6912611|ref|NM012410.1|[6912611]
    • 6741: NM012391
      Homo sapiens prostate epithelium-specific Ets transcription factor (PDEF), mRNA
      gi|6912579|ref|NM012391.1|[6912579]
    • 6742: NM012375
      Homo sapiens olfactory receptor, family 52, subfamily A, member 1 (OR52A1), mRNA
      gi|6912559|ref|NM012375.1|[6912559]
    • 6743: NM012368
      Homo sapiens olfactory receptor, family 2, subfamily C, member 1 (OR2C1), mRNA
      gi|6912555|ref|NM012368.1|[6912555]
    • 6744: NM012360
      Homo sapiens olfactory receptor, family 1, subfamily F, member 8 (OR1F8), mRNA
      gi|6912553|ref|NM012360.1|[6912553]
    • 6745: NM012352
      Homo sapiens olfactory receptor, family 1, subfamily A, member 2 (OR1A2), mRNA
      gi|6912551|ref|NM012352.1|[6912551]
    • 6746: NM012351
      Homo sapiens olfactory receptor, family 10, subfamily J, member 1 (OR10J1), mRNA
      gi|6912549|ref|NM012351.1|[6912549]
    • 6747: NM012344
      Homo sapiens neurotensin receptor 2 (NTSR2), mRNA
      gi|6912537|ref|NM012344.1|[6912537]
    • 6748: NM012314
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 (KIR2D54), mRNA
      gi|6912475|ref|NM012314.1|[6912475]
    • 6749: NM012313
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2D53), mRNA
      gi|6912473|ref|NM012313.1|[6912473]
    • 6750: NM012312
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 (KIR2D52), mRNA
      gi|6912471|ref|NM012312.1|[6912471]
    • 6751: NM012211
      Homo sapiens integrin, alpha 11 (ITGA11), mRNA
      gi|6912435|ref|NM012211.1|[6912435]
    • 6752: NM012275
      Homo sapiens interleukin-1 receptor antagonist homolog 1 (IL1HY1), mRNA
      gi|6912431|ref|NM012275.1|[6912431]
    • 6753: NM004525
      Homo sapiens low density lipoprotein-related protein 2 (LRP2), mRNA
      gi|6806918|ref|NM004525.1|[6806918]
    • 6754: NM004304
      Homo sapiens anaplastic lymphoma kinase (Ki-1) (ALK), mRNA
      gi|6715586|ref|NM004304.2|[6715586]
    • 6755: NM000686
      Homo sapiens angiotensin receptor 2 (AGTR2), mRNA
      gi|6715584|ref|NM000686.2|[6715584]
    • 6756: NM007366
      Homo sapiens phospholipase A2 receptor 1, 180 kD (PLA2R1), mRNA
      gi|6679370|ref|NM007366.1|[6679370]
    • 6757: NM005385
      Homo sapiens natural killer-tumor recognition sequence (NKTR), mRNA
      gi|6631099|ref|NM005385.2|[6631099]
    • 6758: NM005266
      Homo sapiens gap junction protein, alpha 5, 40 kD (connexin 40) (GJA5), mRNA
      gi|6631082|ref|NM005266.2|[6631082]
    • 6759: NM000827
      Homo sapiens glutamate receptor, ionotropic, AMPA 1 (GRIA1), mRNA
      gi|6552333|ref|NM000827.21[6552333]
    • 6760: NM001619
      Homo sapiens adrenergic, beta, receptor kinase 1 (ADRBK1), mRNA
      gi|6138971|ref|NM001619.2|[6138971]
    • 6761: NM000810
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 5 (GABRA5), mRNA
      gi|6031207|ref|NM000810.2|[6031207]
    • 6762: NM003006
      Homo sapiens selectin P ligand (SELPLG), mRNA
      gi|6031197|ref|NM003006.2|[6031197]
    • 6763: NM001480
      Homo sapiens galanin receptor 1 (GALR1), mRNA
      gi|6031165|ref|NM001480.21[6031165]
    • 6764: NM001992
      Homo sapiens coagulation factor II (thrombin) receptor (F2R), mRNA
      gi|6031164|ref|NM001992.2|[6031164]
    • 6765: NM000677
      Homo sapiens adenosine A3 receptor (ADORA3), mRNA
      gi|6031156|ref|NM000677.21[6031156]
    • 6766: NM001526
      Homo sapiens hypocretin (orexin) receptor 2 (HCRTR2), mRNA
      gi|6006037|ref|NM001526.2|[6006037]
    • 6767: NM000885
      Homo sapiens integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4), mRNA
      gi|6006032|ref|NM000885.2|[6006032]
    • 6768: NM002377
      Homo sapiens MAS1 oncogene (MAS1), mRNA
      gi|6006022|ref|NM002377.21[6006022]
    • 6769: NM000887
      Homo sapiens integrin, alpha X (antigen CD11C (p150), alpha polypeptide) (ITGAX), mRNA
      gi|6006014|ref|NM000887.2|[6006014]
    • 6770: NM000419
      Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex,
      antigen CD41B) (ITGA2B), mRNA
      gi|6006009|ref|NM000419.2|[6006009]
    • 6771: NM002203
      Homo sapiens integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2), mRNA
      gi|6006008|ref|NM002203.21[6006008]
    • 6772: NM000843
      Homo sapiens glutamate receptor, metabotropic 6 (GRM6), mRNA
      gi|6006006|ref|NM000843.2|[6006006]
    • 6773: NM000838
      Homo sapiens glutamate receptor, metabotropic 1 (GRM1), mRNA
      gi|6006005|ref|NM000838.2|[6006005]
    • 6774: NM000835
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2C (GRIN2C),
      mRNA
      gi|6006004|ref|NM000835.2|[6006004]
    • 6775: NM000834
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B),
      mRNA
      gi|6006003|ref|NM000834.2|[6006003]
    • 6776: NM000833
      Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A),
      mRNA
      gi|6006002|ref|NM000833.2|[6006002]
    • 6777: NM007155
      Homo sapiens zona pellucida glycoprotein 3A (sperm receptor) (ZP3A), mRNA
      gi|6005983|ref|NM007155.1|[6005983]
    • 6778: NM007124
      Homo sapiens utrophin (homologous to dystrophin) (UTRN), mRNA
      gi|6005937|ref|NM007124.1|[6005937]
    • 6779: NM007114
      Homo sapiens TATA element modulatory factor 1 (TMF1), mRNA
      gi|6005903|ref|NM007114.1|[6005903]
    • 6780: NM007273
      Homo sapiens B-cell associated protein (REA), mRNA
      gi|6005853|ref|NM007273.1|[6005853]
    • 6781: NM007160
      Homo sapiens olfactory receptor, family 2, subfamily H, mer-er 3 (OR2H3), mRNA
      gi|6005821|ref|NM007160.1|[6005821]
    • 6782: NM007227
      Homo sapiens G protein-coupled receptor 45 (GPR45), mRNA
      gi|6005769|ref|NM007227.1|[6005769]
    • 6783: NM006934
      Homo sapiens solute carrier family 6 (neurotransmitter transporter, glycine), member 9 (SLC6A9), mRNA
      gi|5902093|ref|NM006934.1|[5902093]
    • 6785: NM007011
      Homo sapiens putative transmembrane protein (HS1-2), mRNA
      gi|5901977|ref|NM007011.1|[5901977]
    • 6786: NM007045
      Homo sapiens FGFR1 oncogene partner (FOP), mRNA
      gi|5901953|ref|NM007045.1|[5901953]
    • 6787: NM006889
      Homo sapiens CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) (CD86), mRNA
      gi|5901919|ref|NM006889.1|[5901919]
    • 6788: NM006749
      Homo sapiens solute carrier family 20 (phosphate transporter), member 2 (SLC20A2), mRNA
      gi|5803172|ref|NM006749.1|[5803172]
    • 6789: NM006770
      Homo sapiens macrophage receptor with collagenous structure (MARCO), mRNA
      gi|5803079|ref|NM006770.1|[5803079]
    • 6790: NM006840
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 (LILRB5), mRNA
      gi|5803069|ref|NM006840.1|[5803069]
    • 6791: NM006866
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 (LILRA2), mRNA
      gi|5803067|ref|NM006866.1|[5803067]
    • 6792: NM006863
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 (LILRA1), mRNA
      gi|5803065|ref|NM006863.1|[583065]
    • 6793: NM006847
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 (LILRB4), mRNA
      gi|5803063|ref|NM006847.1|[5803063]
    • 6794: NM006865
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 (LILRA3), mRNA
      gi|5803061|ref|NM006865.1|[5803061]
    • 6795: NM006864
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (LILRB3), mRNA
      gi|5803059|ref|NM006864.1|[5803059]
    • 6796: NM006738
      Homo sapiens lymphoid blast crisis oncogene (LBC), mRNA
      gi|5803057|ref|NM006738.1|[5803057]
    • 6797: NM006737
      Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 (KIR3DL2), mRNA
      gi|5803051|ref|NM006737.1|[5803051]
    • 6799: NM006564
      Homo sapiens G protein-coupled receptor (TYMSTR), mRNA
      gi|5730105|ref|NM006564.1|[5730105]
    • 6800: NM001561
      Homo sapiens tumor necrosis factor receptor superfamily, member 9 (TNFRSF9), mRNA
      gi|5730094|ref|NM001561.2|[5730094]
    • 6801: NM006664
      Homo sapiens small inducible cytokine subfamily A (Cys-Cys), member 27 (SCYA27),
      mRNA
      gi|5730034|ref|NM006664.1|[5730034]
    • 6802: NM006583
      Homo sapiens retinal pigment epithelium-derived rhodopsin homolog (RRH), mRNA
      gi|5730018|ref|NM006583.1|[5730018]
    • 6803: NM006505
      Homo sapiens poliovirus receptor (PVR), mRNA
      gi|5729994ref|NM006505.1|[5729994]
    • 6804: NM006637
      Homo sapiens olfactory receptor, family 5, subfamily I, member 1 (OR5I1), mRNA
      gi|5729959|ref|NM006637.1|[5729959]
    • 6805: NM006669
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (LILRB1), mRNA
      gi|5729926|ref|NM006669.1|[5729926]
    • 6806: NM006611
      Homo sapiens killer cell lectin-like receptor subfamily A, member 1 (KLRA1), mRNA
      gi|5729898|ref|NM006611.1|[5729898]
    • 6807: NM006496
      Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 (GNA13), mRNA
      gi|5729849|ref|NM006496.1|[5729849]
    • 6808: NM006529
      Homo sapiens glycine receptor, alpha 3 (GLRA3), mRNA
      gi|5729843|ref|NM006529.1|[5729843]
    • 6809: NM006639
      Homo sapiens cysteinyl leukotriene receptor 1 (CYSLT1), mRNA
      gi|5729797|ref|NM006639.1|[5729797]
    • 6810: NM006293
      Homo sapiens TYRO3 protein tyrosine kinase (TYRO3), mRNA
      gi|5454141|ref|NM006293.1|[5454141]
    • 6813: NM006238
      Homo sapiens peroxisome proliferative activated receptor, delta (PPARD), mRNA
      gi|5453939|ref|NM006238.1|[5453939]
    • 6814: NM006189
      Homo sapiens olfactory marker protein (OMP), mRNA
      gi|5453827|ref|NM006189.1|[5453827]
    • 6815: NM006182
      Homo sapiens discoidin domain receptor family, member 2 (DDR2), mRNA
      gi|5453813|ref|NM006182.1|[5453813]
    • 6816: NM006180
      Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), mRNA
      gi|5453811|ref|NM006180.1|[5453811]
    • 6817: NM006403
      Homo sapiens enhancer of filamentation 1 (cas-like docking; Crk-associated substrate related) (HEF1), mRNA
      gi|5453679|ref|NM006403.1|[5453679]
    • 6818: NM006143
      Homo sapiens G protein-coupled receptor 19 (GPR19), mRNA
      gi|5453665|ref|NM006143.1|[5453665]
    • 6819: NM006404
      Homo sapiens protein C receptor, endothelial (EPCR) (PROCR), mRNA
      gi|5453645|ref|NM006404.1|[5453645]
    • 6820: NM006419
      Homo sapiens small inducible cytokine B subfamily (Cys-X-Cys motif), member (B-cell chemoattractant) (SCYB13), mRNA
      gi|5453576|ref|NM006419.1|[5453576]
    • 6821: NM005954
      Homo sapiens metallothionein 3 (growth inhibitory factor (neurotrophic)) (MT3),
      mRNA
      gi|5174761|ref|NM005954.1|[5174761]
    • 6822: NM006006
      Homo sapiens zinc finger protein 145 (Kruppel-like, expressed in promyelocytic
      leukemia) (ZNF145), mRNA
      gi|5174752|ref|NM006006.1|[5174752]
    • 6823: NM006072
      Homo sapiens small inducible cytokine subfamily A (Cys-Cys), member 26 (SCYA26),
      mRNA
      gi|5174670|ref|NM006072.1|[5174670]
    • 6824: NM005972
      Homo sapiens pancreatic polypeptide receptor 1 (PPYR1), mRNA
      gi|5174638|ref|NM005972.1|[5174638]
    • 6825: NM005913
      Homo sapiens melanocortin 5 receptor (MC5R), mRNA
      gi|5174534|ref|NM005913.1|[5174534]
    • 6826: NM005912
      Homo sapiens melanocortin 4 receptor (MC4R), mRNA
      gi|5174532|ref|NM005912.1|[5174532]
    • 6827: NM006028
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3B (HTR3B), mRNA
      gi|5174468|ref|NM006028.1|[5174468]
    • 6828: NM005628
      Homo sapiens solute carrier family 1 (neutral amino acid transporter), member 5
      (SLC1A5), mRNA
      gi|5032092|ref|NM005628.1|[5032092]
    • 6829: NM005767
      Homo sapiens purinergic receptor (family A group 5) (P2Y5), mRNA
      gi|5031968|ref|NM005767.1|[5031968]
    • 6830: NM005592
      Homo sapiens muscle, skeletal, receptor tyrosine kinase (MUSK), mRNA
      gi|5031926|ref|NM005592.1|[5031926]
    • 6831: NM005874
      Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 (LILRB2), mRNA
      gi|5031910|ref|NM005874.1|[5031910]
    • 6832: NM005810
      Homo sapiens killer cell lectin-like receptor subfamily G, member 1 (KLRG1), mRNA
      gi|5031900|ref|NM005810.1|[5031900]
    • 6833: NM005544
      Homo sapiens insulin receptor substrate 1 (IRS1), mRNA
      gi|5031804|ref|NM005544.1|[5031804]
    • 6834: NM005535
      Homo sapiens interleukin 12 receptor, beta 1 (IL12RB1), mRNA
      gi|5031784|ref|NM005535.1|[5031784]
    • 6835: NM005683
      Homo sapiens G protein-coupled receptor 55 (GPR55), mRNA
      gi|5031722|ref|NM005683.1|[5031722]
    • 6836: NM005684
      Homo sapiens G protein-coupled receptor 52 (GPR52), mRNA
      gi|5031720|ref|NM005684.1|[5031720]
    • 6837: NM001621
      Homo sapiens aryl hydrocarbon receptor (AHR), mRNA
      gi|5016091|ref|NM001621.2|[5016091]
    • 6838: NM005429
      Homo sapiens vascular endothelial growth factor C (VEGFC), mRNA
      gi|4885652|ref|NM005429.1|[4885652]
    • 6839: NM005424
      Homo sapiens tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (TIE), mRNA
      gi|4885630|ref|NM005424.1|[4885630]
    • 6840: NM005408
      Homo sapiens small inducible cytokine subfamily A (Cys-Cys), member 13 (SCYA13),
      mRNA
      gi|4885586|ref|NM005408.1|[4885586]
    • 6841: NM005328
      Homo sapiens hyaluronan synthase 2 (HAS2), mRNA
      gi|4885390|ref|NM005328.1|[4885390]
    • 6842: NM005314
      Homo sapiens gastrin-releasing peptide receptor (GRPR), mRNA
      gi|4885360|ref|NM005314.1|[4885360]
    • 6843: NM005311
      Homo sapiens growth factor receptor-bound protein 10 (GRB10), mRNA
      gi|4885352|ref|NM005311.1|[4885352]
    • 6844: NM005308
      Homo sapiens G protein-coupled receptor kinase 5 (GPRK5), mRNA
      gi|4885348|ref|NM005308.1|[4885348]
    • 6845: NM005286
      Homo sapiens G protein-coupled receptor 8 (GPR8), mRNA
      gi|4885344|ref|NM005286.1|[4885344]
    • 6846: NM005285
      Homo sapiens G protein-coupled receptor 7 (GPR7), mRNA
      gi|4885342|ref|NM005285.1|[4885342]
    • 6847: NM005284
      Homo sapiens G protein-coupled receptor 6 (GPR6), mRNA
      gi|4885340|ref|NM005284.1|[4885340]
    • 6848: NM005458
      Homo sapiens G protein-coupled receptor 51 (GPR51), mRNA
      gi|4885336|ref|NM005458.1|[4885336]
    • 6849: NM005282
      Homo sapiens G protein-coupled receptor 4 (GPR4), mRNA
      gi|4885334|ref|NM005282.1|[4885334]
    • 6850: NM005306
      Homo sapiens G protein-coupled receptor 43 (GPR43), mRNA
      gi|4885332|ref|NM005306.1|[4885332]
    • 6851: NM005305
      Homo sapiens G protein-coupled receptor 42 (GPR42), mRNA
      gi|4885330|ref|NM005305.1|[4885330]
    • 6852: NM005304
      Homo sapiens G protein-coupled receptor 41 (GPR41), mRNA
      gi|4885328|ref|NM005304.1|[4885328]
    • 6853: NM005303
      Homo sapiens G protein-coupled receptor 40 (GPR40), mRNA
      gi|4885326|ref|NM005303.1|[4885326]
    • 6854: NM005281
      Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA
      gi|4885324|ref|NM005281.1|[4885324]
    • 6855: NM005302
      Homo sapiens G protein-coupled receptor 37 (endothelin receptor type B-like) (GPR37), mRNA
      gi|4885322|ref|NM005302.1|[4885322]
    • 6856: NM005301
      Homo sapiens G protein-coupled receptor 35 (GPR35), mRNA
      gi|4885320|ref|NM005301.1|[4885320]
    • 6857: NM005300
      Homo sapiens G protein-coupled receptor 34 (GPR34), mRNA
      gi|4885318|ref|NM005300.1|[4885318]
    • 6858: NM005299
      Homo sapiens G protein-coupled receptor 31 (GPR31), mRNA
      gi|4885316|ref|NM005299.1|[4885316]
    • 6859: NM005298
      Homo sapiens G protein-coupled receptor 25 (GPR25), mRNA
      gi|4885314|ref|NM005298.1|[4885314]
    • 6860: NM005297
      Homo sapiens G protein-coupled receptor 24 (GPR24), mRNA
      gi|4885312|ref|NM005297.1|[4885312]
    • 6861: NM005296
      Homo sapiens G protein-coupled receptor 23 (GPR23), mRNA
      gi|4885310|ref|NM005296.1|[4885310]
    • 6862: NM005295
      Homo sapiens G protein-coupled receptor 22 (GPR22), mRNA
      gi|4885308|ref|NM005295.1|[4885308]
    • 6863: NM005294
      Homo sapiens G protein-coupled receptor 21 (GPR21), mRNA
      gi|4885306|ref|NM005294.1|[4885306]
    • 6864: NM005293
      Homo sapiens G protein-coupled receptor 20 (GPR20), mRNA
      gi|4885304|ref|NM005293.1|[4885304]
    • 6865: NM005279
      Homo sapiens G protein-coupled receptor 1 (GPR1), mRNA
      gi|4885302|ref|NM005279.1|[4885302]
    • 6866: NM005291
      Homo sapiens G protein-coupled receptor 17 (GPR17), mRNA
      gi|4885300|ref|NM005291.1|[4885300]
    • 6867: NM005290
      Homo sapiens G protein-coupled receptor 15 (GPR15), mRNA
      gi|4885298|ref|NM005290.1|[4885298]
    • 6868: NM005288
      Homo sapiens G protein-coupled receptor 12 (GPR12), mRNA
      gi|4885294|ref|NM005288.1|[4885294]
    • 6869: NM005264
      Homo sapiens GDNF family receptor alpha 1 (GFRA1), mRNA
      gi|4885268|ref|NM005264.1|[4885268]
    • 6870: NM005246
      Homo sapiens fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) (FER),
      mRNA
      gi|4885230|ref|NM005246.1|[4885230]
    • 6871: NM005233
      Homo sapiens EphA3 (EPHA3), mRNA
      gi|4885210|ref|NM005233.1|[4885210]
    • 6872: NM005227
      Homo sapiens ephrin-A4 (EFNA4), mRNA
      gi|4885196|ref|NM005227.1|[4885196]
    • 6873: NM005211
      Homo sapiens colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog (CSF1R), mRNA
      gi|4885158|ref|NM005211.1|[4885158]
    • 6875: NM005161
      Homo sapiens angiotensin receptor-like 1 (AGTRL1), mRNA
      gi|4885056|ref|NM005161.1|[4885056]
    • 6876: NM005092
      Homo sapiens tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18), mRNA
      gi|4827033|ref|NM005092.1|[4827033]
    • 6877: NM005118
      Homo sapiens tumor necrosis factor (ligand) superfamily, member 15 (TNFSF15), mRNA
      gi|4827031|ref|NM005118.1|[4827031]
    • 6878: NM005048
      Homo sapiens parathyroid hormone receptor 2 (PTHR2), mRNA
      gi|4826953|ref|NM005048.1|[4826953]
    • 6879: NM004963
      Homo sapiens guanylate cyclase 2C (heat stable enterotoxin receptor) (GUCY2C),
      mRNA
      gi|4826751|ref|NM004963.1|[4826751]
    • 6880: NM005145
      Homo sapiens guanine nucleotide binding protein (G protein), gamma 7 (GNG7), mRNA
      gi|4826745|ref|NM005145.1|[4826745]
    • 6881: NM004952
      Homo sapiens ephrin-A3 (EFNA3), mRNA
      gi|4826707|ref|NM004952.1|[4826707]
    • 6882: NM004736
      Homo sapiens xenotropic and polytropic retrovirus receptor (XPR1), mRNA
      gi|4759333|ref|NM004736.1|[4759333]
    • 6883: NM004664
      Homo sapiens Vertebrate LIN7 homolog 1, Tax interaction protein 33 (VELI1), mRNA
      gi|4759305|ref|NM004664.1|[4759305]
    • 6884: NM004195
      Homo sapiens tumor necrosis factor receptor superfamily, member 18 (TNFRSF18),
      mRNA
      gi|4759245|ref|NM004195.1|[4759245]
    • 6885: NM004612
      Homo sapiens transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53 kD) (TGFBR1), mRNA
      gi|4759225|ref|NM004612.1|[4759225]
    • 6887: NM004154
      Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6), mRNA
      gi|4758863|ref|NM004154.1|[4758863]
    • 6888: NM004244
      Homo sapiens CD163 antigen (CD163), mRNA
      gi|4758721|ref|NM004244.1|[4758721]
    • 6889: NM002332
      Homo sapiens low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) (LRP1), mRNA
      gi|4758685|ref|NM002332.1|[4758685]
    • 6890: NM004514
      Homo sapiens interleukin enhancer binding factor 1 (ILF1), mRNA
      gi|4758599|ref|NM004514.1|[4758599]
    • 6891: NM004633
      Homo sapiens interleukin 1 receptor, type II (IL1R2), mRNA
      gi|4758597|ref|NM004633.1|[4758597]
    • 6892: NM004512
      Homo sapiens interleukin 11 receptor, alpha (IL11RA), mRNA
      gi|4758593|ref|NM004512.1|[4758593]
    • 6894: NM000826
      Homo sapiens glutamate receptor, ionotropic, AMPA 2 (GRIA2), mRNA
      gi|4758479|ref|NM000826.1|[4758479]
    • 6896: NM004224
      Homo sapiens G protein-coupled receptor 50 (GPR50), mRNA
      gi|4758467|ref|NM004224.1|[4758467]
    • 6898: NM004246
      Homo sapiens glucagon-like peptide 2 receptor (GLP2R), mRNA
      gi|4758437|ref|NM004246.1|[4758437]
    • 6899: NM004293
      Homo sapiens guanine deaminase (GDA), mRNA
      gi|4758425|ref|NM004293.1|[4758425]
    • 6900: NM002030
      Homo sapiens formyl peptide receptor-like 2 (FPRL2), mRNA
      gi|4758401|ref|NM002030.2|[4758401]
    • 6901: NM004469
      Homo sapiens c-fos induced growth factor (vascular endothelial growth factor D)
      (FIGF), mRNA
      gi|4758377|ref|NM004469.1|[4758377]
    • 6902: NM004107
      Homo sapiens Fc fragment of IgG, receptor, transporter, alpha (FCGRT), mRNA
      gi|4758345|ref|NM004107.1|[4758345]
    • 6903: NM004101
      Homo sapiens coagulation factor II (thrombin) receptor-like 2 (F2RL2), mRNA
      gi|4758325|ref|NM004101.1|[4758325]
    • 6904: NM004447
      Homo sapiens epidermal growth factor receptor pathway substrate 8 (EPS8), mRNA
      gi|4758295|ref|NM004447.1|[4758295]
    • 6905: NM004431
      Homo sapiens EphA2 (EPHA2), mRNA
      gi|4758277|ref|NM004431.1|[4758277]
    • 6906: NM004093
      Homo sapiens ephrin-B2 (EFNB2), mRNA
      gi|4758249|ref|NM004093.1|[4758249]
    • 6907: NM004429
      Homo sapiens ephrin-B1 (EFNB1), mRNA
      gi|4758247|ref|NM004429.1|[4758247]
    • 6908: NM004428
      Homo sapiens ephrin-A1 (EFNA1), mRNA
      gi|4758245|ref|NM004428.1|[4758245]
    • 6909: NM004393
      Homo sapiens dystroglycan 1 (dystrophin-associated glycoprotein 1) (DAG1), mRNA
      gi|4758115|ref|NM004393.1|[4758115]
    • 6910: NM004383
      Homo sapiens c-src tyrosine kinase (CSK), mRNA
      gi|4758077|ref|NM004383.1|[4758077]
    • 6911: NM004778
      Homo sapiens G protein-coupled receptor 44 (GPR44), mRNA
      gi|4758069|ref|NM004778.1|[4758069]
    • 6912: NM004382
      Homo sapiens corticotropin releasing hormone receptor 1 (CRHR1), mRNA
      gi|4758059|ref|NM004382.1|[4758059]
    • 6913: NM004072
      Homo sapiens chemokine-like receptor 1 (CMKLR1), mRNA
      gi|4758013|ref|NM004072.1|[4758013]
    • 6914: NM004329
      Homo sapiens bone morphogenetic protein receptor, type IA (BMPR1A), mRNA
      gi|4757853|ref|NM004329.1|[4757853]
    • 6915: NM004313
      Homo sapiens arrestin, beta 2 (ARRB2), mRNA
      gi|4757779|ref|NM004313.1|[4757779]
    • 6916: NM004039
      Homo sapiens annexin A2 (ANXA2), mRNA
      gi|4757755|ref|NM004039.1|[4757755]
    • 6917: NM000806
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1), mRNA
      gi|4585862|ref|NM000806.2|[4585862]
    • 6918: NM002529
      Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), mRNA
      gi|4585711|ref|NM002529.2|[4585711]
    • 6919: NM000395
      Homo sapiens colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (CSF2RB), mRNA
      gi|4559407|ref|NM000395.1|[4559407]
    • 6920: NM000211
      Homo sapiens integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) (ITGB2), mRNA
      gi|4557885|ref|NM000211.1|[4557885]
    • 6921: NM000208
      Homo sapiens insulin receptor (INSR), mRNA
      gi|4557883|ref|NM000208.1|[4557883]
    • 6922: NM000206
      Homo sapiens interleukin 2 receptor, gamma (severe combined immunodeficiency) (IL2RG), mRNA
      gi|4557881|ref|NM000206.1|[4557881]
    • 6923: NM000416
      Homo sapiens interferon gamma receptor 1 (IFNGR1), mRNA
      gi|4557879|ref|NM000416.1|[4557879]
    • 6924: NM000201
      Homo sapiens intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
      (ICAM1), mRNA
      gi|4557877|ref|NM000201.1|[4557877]
    • 6925: NM000459
      Homo sapiens TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) (TEK), mRNA
      gi|4557868|ref|NM000459.1|[4557868]
    • 6926: NM001053
      Homo sapiens somatostatin receptor 5 (SSTR5), mRNA
      gi|4557864|ref|NM001053.1|[4557864]
    • 6927: NM001052
      Homo sapiens somatostatin receptor 4 (SSTR4), mRNA
      gi|4557862|ref|NM001052.1|[4557862]
    • 6928: NM001051
      Homo sapiens somatostatin receptor 3 (SSTR3), mRNA
      gi|4557860|ref|NM001051.1|[4557860]
    • 6929: NM001050
      Homo sapiens somatostatin receptor 2 (SSTR2), mRNA
      gi|4557858|ref|NM001050.1|[4557858]
    • 6930: NM001049
      Homo sapiens somatostatin receptor 1 (SSTR1), mRNA
      gi|4557856|ref|NM001049.1|[4557856]
    • 6931: NM000245
      Homo sapiens met proto-oncogene (hepatocyte growth factor receptor) (MET), mRNA
      gi|4557746|ref|NM000245.1|[4557746]
    • 6932: NM000242
      Homo sapiens mannose-binding lectin (protein C) 2, soluble (opsonic defect) (MBL2), mRNA
      gi|4557738|ref|NM000242.1|[4557738]
    • 6933: NM000237
      Homo sapiens lipoprotein lipase (LPL), mRNA
      gi|4557726|ref|NM000237.1|[4557726]
    • 6934: NM000236
      Homo sapiens lipase, hepatic (LIPC), mRNA
      gi|4557722|ref|NM000236.1|[4557722]
    • 6935: NM000233
      Homo sapiens luteinizing hormone/choriogonadotropin receptor (LHCGR), mRNA
      gi|4557716|ref|NM000233.1|[4557716]
    • 6936: NM000222
      Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), mRNA
      gi|4557694|ref|NM000222.1|[4557694]
    • 6937: NM000212
      Homo sapiens integrin, beta 3 (platelet glycoprotein 111a, antigen CD61) (ITGB3), mRNA
      gi|4557676|ref|NM000212.1|[4557676]
    • 6939: NM000418
      Homo sapiens interleukin 4 receptor (IL4R), mRNA
      gi|4557668|ref|NM000418.1|[4557668]
    • 6940: NM000417
      Homo sapiens interleukin 2 receptor, alpha (IL2RA), mRNA
      gi|4557666|ref|NM000417.1|[4557666]
    • 6941: NM001551
      Homo sapiens immunoglobulin (CD79A) binding protein 1 (IGBP1), mRNA
      gi|4557662|ref|NM001551.1|[4557662]
    • 6942: NM000859
      Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR), mRNA
      gi|4557642|ref|NM000859.1|[4557642]
    • 6943: NM001525
      Homo sapiens hypocretin (orexin) receptor 1 (HCRTR1), mRNA
      gi|4557636|ref|NM001525.1|[4557636]
    • 6944: NM001510
      Homo sapiens glutamate receptor, ionotropic, delta 2 (GRID2), mRNA
      gi|4557632|ref|NM001510.1|[4557632]
    • 6945: NM000829
      Homo sapiens glutamate receptor, ionotrophic, AMPA 4 (GRIA4), mRNA
      gi|4557630|ref|NM000829.1|[4557630]
    • 6946: NM001496
      Homo sapiens GDNF family receptor alpha 3 (GFRA3), mRNA
      gi|4557622|ref|NM001496.1|[4557622]
    • 6947: NM000820
      Homo sapiens growth arrest-specific 6 (GAS6), mRNA
      gi|4557616|ref|NM000820.1|[4557616]
    • 6948: NM000155
      Homo sapiens galactose-1-phosphate uridylyltransferase (GALT), mRNA
      gi|4557614|ref|NM000155.1|[4557614]
    • 6949: NM000816
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), mRNA
      gi|4557610|ref|NM000816.1|[4557611]
    • 6950: NM000815
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, delta (GABRD), mRNA
      gi|4557608|ref|NM000815.1|[4557608]
    • 6951: NM000811
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 6 (GABRA6), mRNA
      gi|4557606|ref|NM000811.1|[4557606]
    • 6952: NM000809
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 4 (GABRA4), mRNA
      gi|4557604|ref|NM000809.1|[4557604]
    • 6953: NM000808
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 3 (GABRA3), mRNA
      gi|4557602|ref|NM000808.1|[4557602]
    • 6954: NM000807
      Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 2 (GABRA2), mRNA
      gi|4557600|ref|NM000807.1|[4557600]
    • 6955: NM000121
      Homo sapiens erythropoietin receptor (EPOR), mRNA
      gi|4557561|ref|NM000121.2|[4557561]
    • 6956: NM000118
      Homo sapiens endoglin (Osler-Rendu-Weber syndrome 1) (ENG), mRNA
      gi|4557554|ref|NM000118.1|[4557554]
    • 6957: NM000114
      Homo sapiens endothelin 3 (EDN3), mRNA
      gi|4557544|ref|NM000114.1|[4557544]
    • 6958: NM001365
      Homo sapiens discs, large (Drosophila) homolog 4 (DLG4), mRNA
      gi|4557528|ref|NM001365.1|[4557528]
    • 6959: NM000080
      Homo sapiens cholinergic receptor, nicotinic, epsilon polypeptide (CHRNE), mRNA
      gi|4557462|ref|NM000080.1|[4557462]
    • 6960: NM000751
      Homo sapiens cholinergic receptor, nicotinic, delta polypeptide (CHRND), mRNA
      gi|4557460|ref|NM000751.1|[4557460]
    • 6961: NM000747
      Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) (CHRNB1), mRNA
      gi|4557458|ref|NM000747.1|[4557458) b6Y2: NM000079
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) (CHRNA1), mRNA
      gi|4557456|ref|NM000079.1|[4557456]
    • 6963: NM000074
      Homo sapiens tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome) (TNFSF5), mRNA
      gi|4557432|ref|NM000074.1|[4557432]
    • 6964: NM000073
      Homo sapiens CD3G antigen, gamma polypeptide (TiT3 complex) (CD3G), mRNA
      gi|4557428|ref|NM000073.1|[4557428]
    • 6965: NM000072
      Homo sapiens CD36 antigen (collagen type I receptor, thrombospondin receptor) (CD36), mRNA
      gi|4557418|ref|NM000072.1|[4557418]
    • 6966: NM000388
      Homo sapiens calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) (CASR), mRNA
      gi|4557410|ref|NM000388.1|[4557410]
    • 6967: NM000069
      Homo sapiens calcium channel, voltage-dependent, L type, alpha 1S subunit (CACNA1S), mRNA
      gi|4557400|ref|NM000069.1|[4557400]
    • 6968: NM000041
      Homo sapiens apolipoprotein E (APOE), mRNA
      gi|4557324|ref|NM000041.1|[4557324]
    • 6969: NM000684
      Homo sapiens adrenergic, beta-1-, receptor (ADRB1), mRNA
      gi|4557264|ref|NM000684.1|[4557264]
    • 6970: NM001116
      Homo sapiens adenylate cyclase 9 (ADCY9), mRNA
      gi|4557258|ref|NM001116.1|[4557258]
    • 6971: NM001115
      Homo sapiens adenylate cyclase 8 (brain) (ADCY8), mRNA
      gi|4557256|ref|NM001115.1|[4557256]
    • 6972: NM004001
      Homo sapiens Fc fragment of IgG, low affinity IIb, receptor for (CD32) (FCGR2B),
      mRNA
      gi|4557021|ref|NM004001.1|[4557021]
    • 6975: NM003931
      Homo sapiens WAS protein family, member 1 (WASF1), mRNA
      gi|4507912|ref|NM003931.1|[4507912]
    • 6976: NM003383
      Homo sapiens very low density lipoprotein receptor (VLDLR), mRNA
      gi|4507900|ref|NM003383.1|[4507900]
    • 6977: NM003382
      Homo sapiens vasoactive intestinal peptide receptor 2 (VIPR2), mRNA
      gi|4507898|ref|NM003382.1|[4507898]
    • 6978: NM000376
      Homo sapiens vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR), mRNA
      gi|4507882|ref|NM000376.1|[4507882]
    • 6979: NM003329
      Homo sapiens thioredoxin (TXN), mRNA
      gi|4507744|ref|NM003329.1|[4507744]
    • 6980: NM000369
      Homo sapiens thyroid stimulating hormone receptor (TSHR), mRNA
      gi|4507700|ref|NM000369.1|[4507700]
    • 6981: NM003301
      Homo sapiens thyrotropin-releasing hormone receptor (TRHR), rRNA
      gi|4507680|ref|NM003301.1|[4507680]
    • 6982: NM001244
      Homo sapiens tumor necrosis factor (ligand) superfamily, member 8 (TNFSF8), mRNA
      gi|4507606|ref|NM001244.1|[4507606]
    • 6983: NM003809
      Homo sapiens tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), mRNA
      gi|4507596|ref|NM003809.1|[4507596]
    • 6984: NM001243
      Homo sapiens tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), mRNA
      gi|4507588|ref|NM001243.1|[4507588]
    • 6985: NM001242
      Homo sapiens tumor necrosis factor receptor superfamily, member 7 (TNFRSF7), mRNA
      gi|4507586|ref|NM001242.1|[4507586]
    • 6986: NM000043
      Homo sapiens tumor necrosis factor receptor superfamily, member 6 (TNFRSF6), mRNA
      gi|4507582|ref|NM000043.1|[4507582]
    • 6987: NM003327
      Homo sapiens tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), mRNA
      gi|4507578|ref|NM003327.1|[4507578]
    • 6988: NM001065
      Homo sapiens tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A),
      mRNA
      gi|4507574|ref|NM001065.1|[4507574]
    • 6989: NM001192
      Homo sapiens tumor necrosis factor receptor superfamily, member 17 (TNFRSF17),
      mRNA
      gi|4507572|ref|NM001192.1|[4507572]
    • 6990: NM003820
      Homo sapiens tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) (TNFRSF14), mRNA
      gi|4507570|ref|NM003820.1|[4507570]
    • 6991: NM003790
      Homo sapiens tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein) (TNFRSF12), mRNA
      gi|4507568|ref|NM003790.1|[4507568]
    • 6992: NM002546
      Homo sapiens tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (TNFRSF11B), mRNA
      gi|4507566|ref|NM002546.1|[4507566]
    • 6993: NM003839
      Homo sapiens tumor necrosis factor receptor superfamily, member lla, activator
      of NFKB (TNFRSF11A), mRNA
      gi|4507564|ref|NM003839.1|[4507564]
    • 6994: NM003840
      Homo sapiens tumor necrosis factor receptor superfamily, member 10d, decoy with
      truncated death domain (TNFRSF10D), mRNA
      gi|4507562|ref|NM003840.1|[4507562]
    • 6995: NM003842
      Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B),
      mRNA
      gi|4507560|ref|NM003842.1|[4507560]
    • 6996: NM003844
      Homo sapiens tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A),
      mRNA
      gi|4507558|ref|NM003844.1|[4507558]
    • 6997: NM003692
      Homo sapiens transmembrane protein with EGF-like and two follistatin-like domains 1 (TMEFF1), mRNA
      gi|4507548|ref|NM003692.1|[4507548]
    • 6998: NM003273
      Homo sapiens transmembrane 7 superfamily member 2 (TM7SF2), mRNA
      gi|4507546|ref|NM003273.1|[4507546]
    • 6999: NM003272
      Homo sapiens transmembrane 7 superfamily member 1 (upregulated in kidney) (TM7SF1), mRNA
      gi|4507544|ref|NM003272.1|[4507544]
    • 7000: NM000460
      Homo sapiens thrombopoietin (myeloproliferative leukemia virus oncogene ligand,
      megakaryocyte growth and development factor) (THPO), mRNA
      gi|4507492|ref|NM000460.1|[4507492]
    • 7001: NM003844
      Homo sapiens tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A),
      mRNA
      gi|4507558|ref|NM003844.1|[4507558]
    • 7002: NM003692
      Homo sapiens transmembrane protein with EGF-like and two follistatin-like domains 1 (TMEFF1), mRNA
      gi|4507548|ref|NM003692.1|[4507548]
    • 7003: NM003273
      Homo sapiens transmembrane 7 superfamily member 2 (TM7SF2), mRNA
      gi|4507546|ref|NM003273.1|[4507546]
    • 7004: NM003272
      Homo sapiens transmembrane 7 superfamily member 1 (upregulated in kidney) (TM7SF1), mRNA
      gi|4507544|ref|NM003272.1|[4507544]
    • 7005: NM000460
      Homo sapiens thrombopoietin (myeloproliferative leukemia virus oncogene ligand,
      megakaryocyte growth and development factor) (THPO), mRNA
      gi|4507492|ref|NM000460.1|[4507492]
    • 7006: NM000361
      Homo sapiens thrombomodulin (THBD), mRNA
      gi|4507482|ref|NM000361.1|[4507482]
    • 7007: NM003243
      Homo sapiens transforming growth factor, beta receptor III (betaglycan, 300 kD)
      (TGFBR3), mRNA
      gi|4507470|ref|NM003243.1|[4507470]
    • 7008: NM003234
      Homo sapiens transferrin receptor (p90, CD71) (TFRC), mRNA
      gi|4507456|ref|NM003234.1|[4507456]
    • 7009: NM003608
      Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA
      gi|4507420|ref|NM003608.1|[4507420]
    • 7010: NM001060
      Homo sapiens thromboxane A2 receptor (TBXA2R), mRNA
      gi|4507380|ref|NM001060.1|[4507380]
    • 7012: NM001057
      Homo sapiens tachykinin receptor 2 (TACR2), mRNA
      gi|4507344|ref|NM001057.1|[4507344]
    • 7013: NM003177
      Homo sapiens spleen tyrosine kinase (SYK), mRNA
      gi|4507328|ref|NM003177.1|[4507328]
    • 7015: NM003070
      Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), mRNA
      gi|4507068|ref|NM003070.1|[4507068]
    • 7016: NM003045
      Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+system), member 1 (SLC7A1), mRNA
      gi|4507046|ref|NM003045.1|[4507046]
    • 7017: NM003037
      Homo sapiens signaling lymphocytic activation molecule (SLAM), mRNA
      gi|4506968|ref|NM003037.1|[4506968]
    • 7019: NM001036
      Homo sapiens ryanodine receptor 3 (RYR3), mRNA
      gi|4506758|ref|NM001036.1|[4506758]
    • 7020: NM001035
      Homo sapiens ryanodine receptor 2 (cardiac) (RYR2), mRNA
      gi|4506756|ref|NM001035.1|[4506756]
    • 7023: NM002921
      Homo sapiens retinal G protein coupled receptor (RGR), mRNA
      gi|4506502|ref|NM002921.1|[4506502]
    • 7026: NM002852
      Homo sapiens pentaxin-related gene, rapidly induced by IL-1 beta (PTX3), mRNA
      gi|4506332|ref|NM002852.1|[4506332]
    • 7027: NM002851
      Homo sapiens protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1), mRNA
      gi|4506328|ref|NM002851.1|[4506328]
    • 7028: NM000316
      Homo sapiens parathyroid hormone receptor 1 (PTHR1), mRNA
      gi|4506270|ref|NM000316.1|[4506270]
    • 7029: NM000960
      Homo sapiens prostaglandin 12 (prostacyclin) receptor (IP) (PTGIR), mRNA
      gi|4506262|ref|NM000960.1|[4506262]
    • 7030: NM000959
      Homo sapiens prostaglandin F receptor (FP) (PTGFR), mRNA
      gi|4506260|ref|NM000959.1|[4506260]
    • 7031: NM000958
      Homo sapiens prostaglandin E receptor 4 (subtype EP4) (PTGER4), mRNA
      gi|4506258|ref|NM000958.1|[4506258]
    • 7032: NM000957
      Homo sapiens prostaglandin E receptor 3 (subtype EP3) (PTGER3), mRNA
      gi|4506256|ref|NM000957.1|[4506256]
    • 7033: NM000955
      Homo sapiens prostaglandin E receptor 1 (subtype EP1), 42 kD (PTGER1), mRNA
      gi|4506252|ref|NM000955.1|[4506252]
    • 7034: NM000952
      Homo sapiens platelet-activating factor receptor (PTAFR), mRNA
      gi|4506240|ref|NM000952.1|[4506240]
    • 7035: NM002769
      Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), mRNA
      gi|4506144|ref|NM002769.1|[4506144]
    • 7036: NM000949
      Homo sapiens prolactin receptor (PRLR), mRNA
      gi|4506106|ref|NM000949.1|[4506106]
    • 7037: NM002745
      Homo sapiens mitogen-activated protein kinase 1 (MAPK1), mRNA
      gi|4506086|ref|NM002745.1|[4506086]
    • 7038: NM002702
      Homo sapiens POU domain, class 6, transcription factor 1 (POU6F1), mRNA
      gi|4505968|ref|NM002702.1|[4505968]
    • 7039: NM003967
      Homo sapiens putative neurotransmitter receptor (PNR), mRNA
      gi|4505924|ref|NM003967.1|[4505924]
    • 7040: NM002659
      Homo sapiens plasminogen activator, urokinase receptor (PLAUR), mRNA
      gi|4505864|ref|NM002659.1|[4505864]
    • 7041: NM000926
      Homo sapiens progesterone receptor (PGR), mRNA
      gi|4505766|ref|NM000926.1|[4505766]
    • 7042: NM000288
      Homo sapiens peroxisomal biogenesis factor 7 (PEX7), mRNA
      gi|4505730|ref|NM000288.1|[4505730]
    • 7043: NM000287
      Homo sapiens peroxisomal biogenesis factor 6 (PEX6), mRNA
      gi|4505728|ref|NM000287.1|[4505728]
    • 7044: NM002618
      Homo sapiens peroxisome biogenesis factor 13 (PEX13), mRNA
      gi|4505722|ref|NM002618.1|[4505722]
    • 7045: NM002591
      Homo sapiens phosphoenolpyruvate carboxykinase 1 (soluble) (PCK1), mRNA
      gi|4505638|ref|NM002591.1|[4505638]
    • 7046: NM002586
      Homo sapiens pre-B-cell leukemia transcription factor 2 (PBX2), mRNA
      gi|4505624|ref|NM002586.1|[4505624]
    • 7047: NM002569
      Homo sapiens paired basic amino acid cleaving enzyme (furin, membrane associated
      receptor protein) (PACE), mRNA
      gi|4505578|ref|NM002569.11 4505578]
    • 7048: NM002565
      Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 4 (P2RY4), mRNA
      gi|4505560|ref|NM002565.1)[4505560]
    • 7049: NM002566
      Homo sapiens purinergic receptor P2Y, G-protein coupled, 11 (P2RY11), mRNA
      gi|4505554|ref|NM002566.1|[4505554]
    • 7050: NM002562
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), mRNA
      gi|4505552|ref|NM002562.1|[4505552]
    • 7051: NM002561
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 5 (P2RX5), mRNA
      gi|4505550|ref|NM002561.1|[4505550]
    • 7052: NM002560
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 4 (P2RX4), mRNA
      gi|4505548|ref|NM002560.1|[4505548]
    • 7053: NM002559
      Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 3 (P2RX3), mRNA
      gi|4505546|ref|NM002559.1|[4505546]
    • 7054: NM002556
      Homo sapiens oxysterol binding protein (OSBP), mRNA
      gi|4505530|ref|NM002556.1|[4505530]
    • 7055: NM003696
      Homo sapiens olfactory receptor, family 6, subfamily A, member 1 (OR6A1), mRNA
      gi|4505520|ref|NM003696.1|[4505520]
    • 7056: NM002550
      Homo sapiens olfactory receptor, family 3, subfamily A, member 1 (OR3A1), mRNA
      gi|4505518|ref|NM002550.1|[4505518]
    • 7057: NM002548
      Homo sapiens olfactory receptor, family 1, subfamily D, member 2 (OR1D2), mRNA
      gi|4505516|ref|NM002548.1|[4505516]
    • 7058: NM000914
      Homo sapiens opioid receptor, mu 1 (OPRM1), mRNA
      gi|4505514|ref|NM000914.1|[4505514]
    • 7059: NM000912
      Homo sapiens opioid receptor, kappa 1 (OPRK1), mRNA
      gi|4505510|ref|NM000912.1|[4505510]
    • 7060: NM000911
      Homo sapiens opioid receptor, delta 1 (OPRD1), mRNA
      gi|4505508|ref|NM000911.1|[4505508]
    • 7061: NM002543
      Homo sapiens oxidised low density lipoprotein (lectin-like) receptor 1 (OLR1),
      mRNA
      gi|4505500|ref|NM002543.1|[4505500]
    • 7062: NM003485
      Homo sapiens G protein-coupled receptor 68 (GPR68), mRNA
      gi|4505496|ref|NM003485.1|[4505496]
    • 7063: NM002531
      Homo sapiens neurotensin receptor 1 (high affinity) (NTSR1), mRNA
      gi|4505476|ref|NM002531.1|[4505476]
    • 7064: NM002530
      Homo sapiens neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), mRNA
      gi|4505474|ref|NM002530.1|[4505474]
    • 7065: NM003580
      Homo sapiens neutral sphingomyelinase (N-SMase) activation associated factor (NSMAF), mRNA
      gi|4505464|ref|NM003580.1|[4505464]
    • 7066: NM003872
      Homo sapiens neuropilin 2 (NRP2), mRNA
      gi|4505458|ref|NM003872.1|[4505458]
    • 7067: NM003873
      Homo sapiens neuropilin 1 (NRP1), mRNA
      gi|4505456|ref|NM003873.1|[4505456]
    • 7068: NM000910
      Homo sapiens neuropeptide Y receptor Y2 (NPY2R), mRNA
      gi|4505446|ref|NM000910.1|[4505446]
    • 7069: NM000909
      Homo sapiens neuropeptide Y receptor Y1 (NPY1R), mRNA
      gi|4505444|ref|NM000909.1|[4505444]
    • 7070: NM000908
      Homo sapiens natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) (NPR3), mRNA
      gi|4505440|ref|NM000908.1|[4505440]
    • 7071: NM000906
      Homo sapiens natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (NPR1), mRNA
      gi|4505434|ref|NM000906.1|[4505434]
    • 7072: NM002511
      Homo sapiens neuromedin B receptor (NMBR), mRNA
      gi|4505406|ref|NM002511.1|[4505406]
    • 7073: NM003954
      Homo sapiens mitogen-activated protein kinase kinase kinase 14 (MAP3K14), mRNA
      gi|4505396|ref|NM003954.1|[4505396]
    • 7074: NM002507
      Homo sapiens nerve growth factor receptor (TNFR superfamily, member 16) (NGFR),
      mRNA
      gi|4505392|ref|NM002507.1|[4505392]
    • 7075: NM002447
      Homo sapiens macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
      (MST1R), mRNA
      gi|4505264|ref|NM002447.1|[4505264]
    • 7076: NM002445
      Homo sapiens macrophage scavenger receptor 1 (MSR1), mRNA
      gi|4505258|ref|NM002445.1|[4505258]
    • 7077: NM000529
      Homo sapiens melanocortin 2 receptor (adrenocorticotropic hormone) (MC2R), mRNA
      gi|4505126|ref|NM000529.1|[4505126]
    • 7078: NM002386
      Homo sapiens melanocortin I receptor (alpha melanocyte stimulating hormone receptor) (MC1R), mRNA
      gi|4505124|ref|NM002386.1[4505124]
    • 7079: NM002349
      Homo sapiens lymphocyte antigen 75 (LY75), mRNA
      gi|4505052|ref|NM002349.1|[4505052]
    • 7080: NM002344
      Homo sapiens leukocyte tyrosine kinase (LTK), mRNA
      gi|4505044|ref|NM002344.1|[4505044]
    • 7081: NM000752
      Homo sapiens leukotriene b4 receptor (chemokine receptor-like 1) (LTB4R), mRNA
      gi|4505032|ref|NM000752.1[4505032]
    • 7082: NM002336
      Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6), mRNA
      gi|4505016|ref|NM002336.1|[4505016]
    • 7083: NM002319
      Homo sapiens leucine-rich neuronal protein (LRN), mRNA
      gi|4505012|ref|NM002319.1|[4505012]
    • 7084: NM002303
      Homo sapiens leptin receptor (LEPR), mRNA
      gi|4504978|ref|NM002303.1|[4504978]
    • 7085: NM002291
      Homo sapiens laminin, beta 1 (LAMB1), mRNA
      gi|4504950|ref|NM002291.1[4504950]
    • 7086: NM002258
      Homo sapiens killer cell lectin-like receptor subfamily B, member 1 (KLRB1), mRNA
      gi|4504878|ref|NM002258.1|[4504878]
    • 7087: NM002255
      Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4), mRNA
      gi|4504870|ref|NM002255.1|[4504870]
    • 7088: NM002227
      Homo sapiens Janus kinase 1 (a protein tyrosine kinase) (JAK1), mRNA
      gi|4504802|ref|NM002227.1|[4504802]
    • 7091: NM002210
      Homo sapiens integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen
      CD51) (ITGAV), mRNA
      gi|4504762|ref|NM002210.1|[4504762]
    • 7092: NM002205
      Homo sapiens integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5), mRNA
      gi|4504750|ref|NM002205.1|[4504750]
    • 7094: NM001565
      Homo sapiens small inducible cytokine subfamily B (Cys-X-Cys), member 10 (SCYB10), mRNA
      gi|4504700|ref|NM001565.1|[4504700]
    • 7095: NM001557
      Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNA
      gi|4504682|ref|NM001557.1|[4504682]
    • 7096: NM000634
      Homo sapiens interleukin 8 receptor, alpha (IL8RA), mRNA
      gi|4504680|ref|NM000634.1|[4504680]
    • 7097: NM002185
      Homo sapiens interleukin 7 receptor (IL7R), mRNA
      gi|4504678|ref|NM002185.1|[4504678]
    • 7098: NM002184
      Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), mRNA
      gi|4504674|ref|NM002184.1|[4504674]
    • 7099: NM000565
      Homo sapiens interleukin 6 receptor (IL6R), mRNA
      gi|4504672|ref|NM000565.1|[4504672]
    • 7100: NM000878
      Homo sapiens interleukin 2 receptor, beta (IL2RB), mRNA
      gi|4504664|ref|NM000878.1|[4504664]
    • 7101: NM003854
      Homo sapiens interleukin 1 receptor-like 2 (IL1RL2), mRNA
      gi|4504662|ref|NM003854.1|[4504662]
    • 7102: NM000877
      Homo sapiens interleukin 1 receptor, type I (IL1R1), mRNA
      gi|4504658|ref|NM000877.1|[4504658]
    • 7103: NM003853
      Homo sapiens interleukin 18 receptor accessory protein (IL18RAP), mRNA
      gi|4504656|ref|NM003853.1|[4504656]
    • 7104: NM002189
      Homo sapiens interleukin 15 receptor, alpha (IL15RA), mRNA
      gi|4504648|ref|NM002189.1|[4504648]
    • 7105: NM001559
      Homo sapiens interleukin 12 receptor, beta 2 (IL12RB2), mRNA
      gi|4504642|ref|NM001559.1|[4504642]
    • 7106: NM001558
      Homo sapiens interleukin 10 receptor, alpha (IL10RA), mRNA
      gi|4504632|ref|NM001558.1|[4504632]
    • 7107: NM000876
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R), mRNA
      gi|4504610|ref|NM000876.1|[4504610]
    • 7108: NM000871
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 6 (HTR6), mRNA
      gi|4504544|ref|NM000871.1|[4504544]
    • 7109: NM000869
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3A (HTR3A), mRNA
      gi|4504542|ref|NM000869.1|[4504542]
    • 7110: NM000868
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C), mRNA
      gi|4504540|ref|NM000868.1|[4504540]
    • 7111: NM000867
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B (HTR2B), mRNA
      gi|4504538|ref|NM000867.1|[4504538]
    • 7112: NM000865
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1E (HTR1E), mRNA
      gi|4504536|ref|NM000865.1|[4504536]
    • 7113: NM000863
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B), mRNA
      gi|4504532|ref|NM000863.1|[4504532]
    • 7114: NM000524
      Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A (HTR1A), mRNA
      gi|4504530|ref|NM000524.1|[4504530]
    • 7115: NM000186
      Homo sapiens H factor 1 (complement) (HF1), mRNA
      gi|4504374|ref|NM000186.1|[4504374]
    • 7116: NM001523
      Homo sapiens hyaluronan synthase 1 (HAS1), mRNA
      gi|4504338|ref|NM001523.1|[4504338]
    • 7117: NM000845
      Homo sapiens glutamate receptor, metabotropic 8 (GRM8), mRNA
      gi|4504148|ref|NM000845.1|[4504148]
    • 7118: NM000844
      Homo sapiens glutamate receptor, metabotropic 7 (GRM7), mRNA
      gi|4504146|ref|NM000844.1|[4504146]
    • 7119: NM000841
      Homo sapiens glutamate receptor, metabotropic 4 (GRM4), mRNA
      gi|4504140|ref|NM000841.1|[4504140]
    • 7120: NM000840
      Homo sapiens glutamate receptor, metabotropic 3 (GRM3), mRNA
      gi|4504138|ref|NM000840.1|[4504138]
    • 7121: NM000831
      Homo sapiens glutamate receptor, ionotropic, kainate 3 (GRIK3), mRNA
      gi|4504118|ref|NM000831.1|[4504118]
    • 7122: NM000830
      Homo sapiens glutamate receptor, ionotropic, kainate 1 (GRIK1), mRNA
      gi|4504116|ref|NM000830.1|[4504116]
    • 7123: NM002086
      Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA
      gi|4504110|ref|NM002086.1|[4504110]
    • 7124: NM002082
      Homo sapiens G protein-coupled receptor kinase 6 (GPRK6), mRNA
      gi|4504100|ref|NM002082.1|[4504100]
    • 7125: NM001504
      Homo sapiens G protein-coupled receptor 9 (GPR9), mRNA
      gi|4504098|ref|NM001504.1|[4504098]
    • 7126: NM001508
      Homo sapiens G protein-coupled receptor 39 (GPR39), mRNA
      gi|4504096|ref|NM001508.1|[4504096]
    • 7127: NM001507
      Homo sapiens G protein-coupled receptor 38 (GPR38), mRNA
      gi|4504094|ref|NM001507.1|[4504094]
    • 7128: NM001506
      Homo sapiens G protein-coupled receptor 32 (GPR32), mRNA
      gi|4504092|ref|NM001506.1|[4504092]
    • 7129: NM001505
      Homo sapiens G protein-coupled receptor 30 (GPR30), mRNA
      gi|4504090|ref|NM001505.1|[4504090]
    • 7130: NM000173
      Homo sapiens glycoprotein Ib (platelet), alpha polypeptide (GP1BA) mRNA
      gi|4504070|ref|NM000173.1|[4504070]
    • 7131: NM000824
      Homo sapiens glycine receptor, beta (GLRB), mRNA
      gi|4504022|ref|NM000824.1|[4504022]
    • 7132: NM002063
      Homo sapiens glycine receptor, alpha 2 (GLRA2), mRNA
      gi|4504020|ref|NM002063.1|[4504020]
    • 7133: NM000164
      Homo sapiens gastric inhibitory polypeptide receptor (GIPR), mRNA
      gi|4503998|ref|NM000164.1|[4503998]
    • 7134: NM000823
      Homo sapiens growth hormone releasing hormone receptor (GHRHR), mRNA
      gi|4503996|ref|NM000823.1|[4503996]
    • 7135: NM000163
      Homo sapiens growth hormone receptor (GHR), mRNA
      gi|4503992|ref|NM000163.1|[4503992]
    • 7136: NM000160
      Homo sapiens glucagon receptor (GCGR), mRNA
      gi|4503946|ref|NM000160.1|[4503946]
    • 7137: NM003614
      Homo sapiens galanin receptor 3 (GALR3), mRNA
      gi|4503906|ref|NM003614.1|[4503906]
    • 7138: NM002043
      Homo sapiens gamma-aminobutyric acid (GABA) receptor, rho 2 (GABRR2), mRNA
      gi|4503870|ref|NM002043.1|[4503870]
    • 7139: NM002042
      Homo sapiens gamma-aminobutyric acid (GABA) receptor, rho 1 (GABRR1), mRNA
      gi|4503868|ref|NM002042.1|[4503868]
    • 7140: NM002036
      Homo sapiens Duffy blood group (FY), mRNA
      gi|4503818|ref|NM002036.1|[4503818]
    • 7141: NM001462
      Homo sapiens formyl peptide receptor-like 1 (FPRL1), mRNA
      gi|4503780|ref|NM001462.1|[4503780]
    • 7142: NM002029
      Homo sapiens formyl peptide receptor 1 (FPR1), mRNA
      gi|4503778|ref|NM002029.1|[4503778]
    • 7143: NM001461
      Homo sapiens flavin containing monooxygenase 5 (FMO5), mRNA
      gi|4503760|ref|NM001461.1|[4503760]
    • 7144: NM002020
      Homo sapiens fms-related tyrosine kinase 4 (FLT4), mRNA
      gi|4503752|ref|NM002020.1|[4503752]
    • 7145: NM001459
      Homo sapiens fms-related tyrosine kinase 3 ligand (FLT3LG), mRNA
      gi|4503750|ref|NM001459.1|[4503750]
    • 7146: NM002019
      Homo sapiens fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1), mRNA
      gi|4503748|ref|NM002019.1|[4503748]
    • 7147: NM002002
      Homo sapiens Fc fragment of IgE, low affinity II, receptor for (CD23A) (FCER2),
      mRNA
      gi|4503678|ref|NM002002.1|[4503678]
    • 7148: NM002001
      Homo sapiens Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide (FCER1A), mRNA
      gi|4503674|ref|NM002001.1|[4503674]
    • 7149: NM003950
      Homo sapiens coagulation factor II (thrombin) receptor-like 3 (F2RL3), mRNA
      gi|4503638|ref|NM003950.1|[4503638]
    • 7150: NM001981
      Homo sapiens epidermal growth factor receptor pathway substrate 15 (EPS15), mRNA
      gi|4503592|ref|NM001981.1|[4503592]
    • 7151: NM001974
      Homo sapiens egf-like module containing, mucin-like, hormone receptor-like sequence 1 (EMR1), mRNA
      gi|4503564|ref|NM001974.1|[4503564]
    • 7152: NM001423
      Homo sapiens epithelial membrane protein 1 (EMP1), mRNA
      gi|4503558|ref|NM001423.1|[4503558]
    • 7153: NM003757
      Homo sapiens eukaryotic translation initiation factor 3, subunit 2 (beta, 36 kD)
      (EIF3S2), mRNA
      gi|4503512|ref|NM003757.1|[4503512]
    • 7154: NM001406
      Homo sapiens ephrin-B3 (EFNB3), mRNA
      gi|4503488|ref|NM001406.1|[4503488]
    • 7155: NM001962
      Homo sapiens ephrin-A5 (EFNA5), mRNA
      gi|4503486|ref|NM001962.1|[4503486]
    • 7156: NM001405
      Homo sapiens ephrin-A2 (EFNA2), mRNA
      gi|4503484|ref|NM001405.1|[4503484]
    • 7157: NM003775
      Homo sapiens endothelial differentiation, G-protein-coupled receptor 6 (EDG6),
      mRNA
      gi|4503458|ref|NM003775.1|[4503458]
    • 7158: NM001945
      Homo sapiens diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) (DTR), mRNA
      gi|4503412|ref|NM001945.1|[4503412]
    • 7159: NM001360
      Homo sapiens 7-dehydrocholesterol reductase (DHCR7), mRNA
      gi|4503320|ref|NM001360.1|[4503320]
    • 7160: NM003467
      Homo sapiens chemokine (C-X-C motif), receptor 4 (fusin) (CXCR4), mRNA
      gi|4503174|ref|NM003467.1|[4503174]
    • 7161: NM001338
      Homo sapiens coxsackie virus and adenovirus receptor (CXADR), mRNA
      gi|4503172|ref|NM001338.1|[4503172]
    • 7162: NM003478
      Homo sapiens cullin 5 (CUL5), mRNA
      gi|4503166|ref|NM003478.1|[4503166]
    • 7163: NM001330
      Homo sapiens cardiotrophin 1 (CTF1), mRNA
      gi|4503120|ref|NM001330.1|[4503120]
    • 7164: NM000760
      Homo sapiens colony stimulating factor 3 receptor (granulocyte) (CSF3R), mRNA
      gi|4503080|ref|NM000760.1|[4503080]
    • 7165: NM003805
      Homo sapiens CASP2 and RIPK1 domain containing adaptor with death domain (CRADD), mRNA
      gi|4503030|ref|NM003805.1|[4503030]
    • 7166: NM001877
      Homo sapiens complement component (3d/Epstein Barr virus) receptor 2 (CR2), mRNA
      gi|4503026|ref|NM001877.1|[4503026]
    • 7167: NM001842
      Homo sapiens ciliary neurotrophic factor receptor (CNTFR), mRNA
      gi|4502930|ref|NM001842.1|[4502930]
    • 7168: NM001281
      Homo sapiens cytoskeleton-associated protein 1 (CKAP1), mRNA
      gi|4502848|ref|NM001281.1|[4502848]
    • 7169: NM000750
      Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 4 (CHRNB4), mRNA
      gi|4502836|ref|NM000750.1|[4502836]
    • 7170: NM000749
      Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 3 (CHRNB3), mRNA
      gi|4502834|ref|NM000749.1|[4502834]
    • 7171: NM000748
      Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) (CHRNB2), mRNA
      gi|4502832|ref|NM000748.1|[4502832]
    • 7172: NM000746
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 7 (CHRNA7),
      gi|4502830|ref|NM000746.1|[4502830]
    • 7173: NM000745
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 5 (CHRNA5), mRNA
      gi|4502828|ref|NM000745.1|[4502828]
    • 7174: NM000744
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 4 (CHRNA4), mRNA
      gi|4502826|ref|NM000744.1|[4502826]
    • 7175: NM000742
      Homo sapiens cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) (CHRNA2), mRNA
      gi|4502822|ref|NM000742.1|[4502822]
    • 7176: NM000741
      Homo sapiens cholinergic receptor, muscarinic 4 (CHRM4), mRNA
      gi|4502820|ref|NM000741.1|[4502820]
    • 7177: NM000740
      Homo sapiens cholinergic receptor, muscarinic 3 (CHRM3), mRNA
      gi|4502818|ref|NM000740.1|[4502818]
    • 7178: NM000739
      Homo sapiens cholinergic receptor, muscarinic 2 (CHRM2), mRNA
      gi|4502816|ref|NM000739.1|[4502816]
    • 7179: NM000738
      Homo sapiens cholinergic receptor, muscarinic 1 (CHRM1), mRNA
      gi|4502814|ref|NM000738.1|[4502814]
    • 7181: NM001768
      Homo sapiens CD8 antigen, alpha polypeptide (p32) (CD8A), mRNA
      gi|4502688|ref|NM001768.1|[4502688]
    • 7182: NM001781
      Homo sapiens CD69 antigen (p60, early T-cell activation antigen) (CD69), mRNA
      gi|4502680|ref|NM001781.1|[4502680]
    • 7183: NM001779
      Homo sapiens CD58 antigen, (lymphocyte function-associated antigen 3) (CD58), mRNA
      gi|4502676|ref|NM001779.1|[4502676]
    • 7184: NM000733
      Homo sapiens CD3E antigen, epsilon polypeptide (TiT3 complex) (CD3E), mRNA
      gi|4502670|ref|NM000733.1|[4502670]
    • 7185: NM000732
      Homo sapiens CD3D antigen, delta polypeptide (TiT3 complex) (CD3D), mRNA
      gi|4502668|ref|NM000732.1|[4502668]
    • 7186: NM001775
      Homo sapiens CD38 antigen (p45) (CD38), mRNA
      gi|4502664|ref|NM001775.1|[4502664]
    • 7187: NM001767
      Homo sapiens CD2 antigen (p50), sheep red blood cell receptor (CD2), mRNA
      gi|4502652|ref|NM001767.1|[4502652]
    • 7188: NM001837
      Homo sapiens chemokine (C-C motif) receptor 3 (CCR3), mRNA
      gi|4502636|ref|NM001837.1|[4502636]
    • 7189: NM000731
      Homo sapiens cholecystokinin B receptor (CCKBR), mRNA
      gi|4502608|ref|NM000731.1|[4502608]
    • 7190: NM000730
      Homo sapiens cholecystokinin A receptor (CCKAR), mRNA
      gi|4502606|ref|NM000730.1|[4502606]
    • 7191: NM001742
      Homo sapiens calcitonin receptor (CALCR), mRNA
      gi|4502546|ref|NM001742.1|[4502546]
    • 7192: NM001737
      Homo sapiens complement component 9 (C9), mRNA
      gi|4502510|ref|NM001737.1|[4502510]
    • 7193: NM001736
      Homo sapiens complement component 5 receptor 1 (C5a ligand) (C5R1), mRNA
      gi|4502508|ref|NM001736.1|[4502508]
    • 7194: NM001732
      Homo sapiens butyrophilin, subfamily 1, member A1 (BTN1A1), mRNA
      gi|4502474|ref|NM001732.1|[4502474]
    • 7195: NM001729
      Homo sapiens betacellulin (BTC), mRNA
      gi|4502460|ref|NM001729.1|[4502460]
    • 7196: NM001727
      Homo sapiens bombesin-like receptor 3 (BRS3), mRNA
      gi|4502454|ref|NM001727.1|[4502454]
    • 7197: NM001203
      Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), mRNA
      gi|4502430|ref|NM001203.1|[4502430]
    • 7198: NM000710
      Homo sapiens bradykinin receptor B1 (BDKRB1), mRNA
      gi|4502390|ref|NM000710.1|[4502390]
    • 7199: NM003921
      Homo sapiens B-cell CLL/lymphoma 10 (BCL10), mRNA
      gi|4502378|ref|NM003921.1|[4502378]
    • 7200: NM001168
      Homo sapiens baculoviral IAP repeat-containing 5 (survivin) (BIRC5), mRNA
      gi|4502144|ref|NM001168.1|[4502144]
    • 7201: NM001150
      Homo sapiens alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase
      M, microsomal aminopeptidase, CD13, p150) (ANPEP), mRNA
      gi|4502094|ref|NM001150.1|[4502094]
    • 7202: NM001146
      Homo sapiens angiopoietin 1 (ANGPT1), mRNA
      gi|4502086|ref|NM001146.1|[4502086]
    • 7203: NM000676
      Homo sapiens adenosine A2b receptor (ADORA2B), mRNA
      gi|4501950|ref|NM000676.1|[4501950]
    • 7204: NM000674
      Homo sapiens adenosine A1 receptor (ADORA1), mRNA
      gi|4501946|ref|NM000674.1-|[4501946]
    • 7205: NM001118
      Homo sapiens adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1), mRNA
      gi|4501922|ref|NM001118.1|[4501922]
    • 7206: AF287270
      Homo sapiens mucolipin (MCOLN1) gene, complete cds
      gi|9844925|gb|AF287270.1|AF287270[9844925]
    • 7207: AF287269
      Homo sapiens mucolipin (MCOLN1) mRNA, complete cds
      gi|9844923|gb|AF287269.1|AF287269[9844923]
    • 7208: AF307080
      Homo sapiens lectomedin-3 (LEC3) mRNA, complete cds
      gi|11037015|gb|AF307080.1|AF307080[11037015]
    • 7209: AF307079
      Homo sapiens lectomedin-2 (LEC2) mRNA, complete cds
      gi|1037013|gb|AF307079.1|AF307079[11037013]
    • 7216: AF265242
      Homo sapiens type-I T cell cytokine receptor mRNA, complete cds
      gi|103679|gb|AF265242.1|AF265242[11036791]
    • 7217: AF018284
      Homo sapiens P2Y1 receptor (P2YR1) mRNA, partial cds
      gi|2738815|gb|AF018284.1|AF018284[2738815]
    • 7218: AF017307
      Homo sapiens Ets-related transcription factor (ERT) mRNA, complete cds
      gi|2338755|gb|AF017307.1|AF017307[2338755]
    • 7219: AF106912
      Homo sapiens CRL1 protein (CRL1) mRNA, complete cds
      gi|1022746|gb|AF106912.1|AF106912[11022746]
    • 7220: AB042033
      Homo sapiens FCER1B gene for high affinity IgE receptor beta subunit, 5′ flanking sequence and partial cds
      gi|11022658|dbj|AB042033.1|AB042033[11022658]
    • 7221: AB019000
      Homo sapiens mRNA for G-protein coupled receptor, complete cds
      gi|11022652|dbj|AB019000.1|AB019000[11022652]
    • 7222: AH007076
      Homo sapiens chromosome 13 map 13q34
      gi|3955190|gb|AH007076.1|SEG_HSGRKIN[3955190]
    • 7223: AF019765
      Homo sapiens G protein-coupled receptor kinase 1 and G protein-coupled receptor
      kinase 1b (GRK1) gene, alternatively spliced, alternative exon 6, exon 7, and partial cds
      gi|3955189|gb|AF019765.1|HSGRKIN2[3955189]
    • 7224: AF019764
      Homo sapiens G protein-coupled receptor kinase 1 and G protein-coupled receptor
      kinase 1b (GRK1) gene, alternatively spliced, exon 6, alternative exon 6, and partial cds
      gi|3955188|gb|AF019764.1|HSGRKIN1[3955188]
    • 7225: AF035819
      Homo sapiens macrophage receptor MARCO mRNA, complete cds
      gi|3002790|gb|AF035819.1|AF035819[3002790]
    • 7227: AF253318
      Homo sapiens GFR receptor alpha 4 protein (GFRA4) mRNA, complete cds
      gi|10998399|gb|AF253318.1|AF253318[10998399]
    • 7228: AF077186
      Homo sapiens neuronal nicotinic acetylcholine receptor beta 2 (CHRNB2) gene, complete cds
      gi|10947140|gb|AF077186.2|[10947140]
    • 7229: AF272363
      Homo sapiens neuromedin U receptor 2 (NMUR2) mRNA, complete cds
      gi|10946202|gb|AF272363.1|AF272363[10946202]
    • 7230: AF272362
      Homo sapiens neuromedin U receptor 1 (NMUR1) mRNA, complete cds
      gi|10946200|gb|AF272362.1|AF272362[10946200]
    • 7231: AJ277437
      Homo sapiens mRNA for fibroblast growth factor receptor-like protein 1, (FGFRL1 gene)
      gi|10944886|emb|AJ277437.1|HSA277437[10944886]
    • 7232: G64264
      Alk4/3′ Human Chromosome 12 Homo sapiens STS genomic, sequence tagged site
      gi|9802476|gb|G64264.1|G64264[9802476]
    • 7233: G64261
      AMHR2/ex1-2 Human Chromosome 12 Homo sapiens STS genomic, sequence tagged site
      gi|9802473|gb|G64261.1|G64261[9802473]
    • 7234: G64251
      Alk4/ex1 Human Chromosome 12 Homo sapiens STS genomic, sequence tagged site
      gi|9802463|gb|G64251.1|G64251[9802463]
    • 7235: G64250
      Alk1/ex10 Human Chromosome 12 Homo sapiens STS genomic, sequence tagged site
      gi|9802462|gb|G64250.1|G64250[9802462]
    • 7236: G64249
      Alk1/ex2 Human Chromosome 12 Homo sapiens STS genomic, sequence tagged site
      gi|9802461|gb|G64249.1|G64249[9802461]
    • 7237: AF301005
      Homo sapiens gamma-aminobutyric acid receptor GABA-B1e mRNA, complete cds
      gi|10863757|gb|AF301005.1|AF301005[10863757]
    • 7238: AF269133
      Homo sapiens novel interleukin receptor (NILR) mRNA, complete cds
      gi|10801191|gb|AF269133.1|AF269133[10801190]
    • 7239: AF127670
      Homo sapiens hyaluronic acid receptor (HAR) mRNA, complete cds
      gi|10800121|gb|AF127670.2|AF127670[10800121]
    • 7241: AF284436
      Homo sapiens TIGIRR-1 mRNA, complete cds
      gi|10644689|gb|AF284436.1|AF284436[10644689]
    • 7242: AF284435
      Homo sapiens TIGIRR-2 mRNA, complete cds
      gi|10644687|gb|AF284435.1|AF284435[10644687]
    • 7243: AF284434
      Homo sapiens IL-1Rrp2 mRNA, complete cds
      gi|10644685|gb|AF284434.1|AF284434[10644685]
    • 7244: M35198
      Homo sapiens integrin beta-subunit mRNA, complete cds
      gi|9961228|gb|M35198.3|HUMINTB6A[9961228]
    • 7245: AF302903
      Homo sapiens vomeronasal receptor 1 (VNR19I1) mRNA, complete cds
      gi|10732801|gb|AF302903.1|AF302903[10732801]
    • 7246: AF286095
      Homo sapiens IL-22 receptor (IL22R) mRNA, complete cds
      gi|10719607|gb|AF286095.1|AF286095[10719607]
    • 7248: AF239668
      Homo sapiens CCK-B/gastrin receptor mRNA, complete cds; alternatively spliced
      gi|7677459|gb|AF239668.1|AF239668[7677459]
    • 7249: AF029759
      Homo sapiens mutant G protein-coupled receptor STRL33 (STRL33) gene, STRL33-3K allele, complete cds
      gi|10716827|gb|AF029759.1|AF029759[10716827]
    • 7250: AB041644
      Homo sapiens gene for cysteinyl leukotriene receptor like receptor, complete cds
      gi|10716135|dbj|AB041644.1|AB041644[10716135]
    • 7251: AF237381
      Homo sapiens CCR3 gene and exon 3
      gi|10643653|gb|AF237381.1|AF237380S2[10643653]
    • 7252: AF237380
      Homo sapiens CCR3 gene, promotor and exon 1
      gi|10643652|gb|AF237380.1|AF237380S1[10643652]
    • 7253: AH009867
      Homo sapiens
      gi|10643651|gb|AH009867.1|SEG_AF237380S[10643651]
    • 7254: AF233516
      Homo sapiens PD-1-ligand precursor, mRNA, complete cds
      gi|10567621|gb|AF233516.1|AF233516[10567621]
    • 7255: AJ297688
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 1 and joined CDS
      gi|0445329|emb|AJ297688.1|HSA297688[10445329]
    • 7256: AJ297701
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exons 16-gi|10443220|emb|AJ297701.1|HSA297701[10443220]
    • 7257: AJ297700
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 15
      gi|10443219|emb|AJ297700.1|HSA297700[10443219]
    • 7258: AJ297699
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 14
      gi|10443218|emb|AJ297699.1|HSA297699[10443218]
    • 7259: AJ297698
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 13
      gi|0443217|emb|AJ297698.1HSA297698[10443217]
    • 7260: AJ297697
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 12
      gi|10443216|emb|AJ297697.1|HSA297697[10443216]
    • 7261: AJ297696
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 11
      gi|10443215|emb|AJ297696.1|HSA297696[10443215]
    • 7262: AJ297695
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 10
      gi|10443214|emb|AJ297695.1|HSA297695[10443214]
    • 7263: AJ297694
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 9
      gi|10443213|emb|AJ297694.1|HSA297694[10443213]
    • 7264: AJ297693
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 8
      gi|10443212|emb|AJ297693.1|HSA297693[10443212]
    • 7265: AJ297692
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exons 6-7
      gi|0443211|emb|AJ297692.1|HSA297692[10443211]
    • 7266: AJ297691
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 5
      gi|0443210|emb|AJ297691.1|HSA297691[10443210]
    • 7267: AT2976910
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exon 4
      gi|10443209|emb|AJ297690.1|HSA297690[10443209]
    • 7268: AJ297689
      Homo sapiens partial IL-12RB1 gene for IL-12 receptor beta1 chain, exons 2-3
      gi|10443208|emb|AJ297689.1|HSA297689[10443208]
    • 7269: AJ276452
      Homo sapiens partial pIgR gene for polymeric immunoglobulin receptor, partial intron 1 and partial exon 2
      gi|10303247|emb|AJ276452.1|HSA276452[10303247]
    • 7271: AF254664
      Homo sapiens cysteinyl leukotriene receptor CYSLT2 gene, complete cds
      gi|10442007|gb|AF254664.1|AF254664[10442007]
    • 7273: AC005330
      Homo sapiens chromosome 19, cosmid R34047 and overlapping PCR product, complete
      sequence
      gi|10305189|gb|AC005330.2|AC005330[10305189]
    • 7517: AF176039
      Homo sapiens high mobility group protein-R mRNA, complete cds
      gi|5834272|gb|AF176039.1|AF176039[5834272]
    • 7518: AB041228
      Homo sapiens mRNA for G protein-coupled receptor TGR-1, complete cds
      gi|10257380|dbj|AB041228.1|AB041228[10257380]
    • 7519: AF282262
      Homo sapiens GHRH receptor splice variant 4 mRNA, complete cds
      gi|10242297|gb|AF282262.1|AF282262[10242297]
    • 7520: AF282261
      Homo sapiens GHRH receptor splice variant 3 mRNA, complete cds
      gi|10242295|gb|AF282261.1|AF282261[10242295]
    • 7521: AF282260
      Homo sapiens GHRH receptor splice variant 2 mRNA, complete cds
      gi|10242293|gb|AF282260.1|AF282260[10242293]
    • 7522: AF282259
      Homo sapiens GHRH receptor splice variant 1 mRNA, complete cds
      gi|10242291|gb|AF282259.1|AF282259[10242291]
    • 7523: X80389
      H. sapiens platelet-derived growth factor alpha receptor DNA
      gi|10241726|emb|X80389.2|HSPDGFAD[10241726]
    • 7524: AF177761
      Homo sapiens herstatin (HER-2) mRNA, alternatively spliced, complete cds
      gi|10181232|gb|AF177761.2|AF177761[10181232]
    • 7525: AF005058
      Homo sapiens chemokine receptor (CXCR-4) gene, complete cds
      gi|2735718|gb|AF005058.1|AF005058[2735718]
    • 7526: AF264716
      Homo sapiens complement receptor type 1 (CR1) gene, CR1*SCR25-HUM1 allele, partial cds
      gi|10185787|gb|AF264716.1|AF264716[10185787]
    • 7527: AF264715
      Homo sapiens complement receptor type 1 (CR1) gene, CR1*SCR25-HUM2 allele, partial cds
      gi|10185785|gb|AF264715.1|AF264715[10185785]
    • 7528: AF250237
      Homo sapiens orphan G protein-coupled receptor 85 (GPR85) mRNA, complete cds
      gi|10181092|gb|AF250237.2|AF250237[10181092]
    • 7533: AF189277
      Homo sapiens leukocyte immunoglobulin-like receptor 1 (LIR1) gene, complete cds
      gi|9954209|gb|AF189277.1|AF189277[9954209]
    • 7534: AB010994
      Homo sapiens hedgehog gene, exon 3 and complete cds
      gi|10047225|dbj|AB010994.2|AB010581S3[10047225]
    • 7535: AB010993
      Homo sapiens hedgehog gene, exon 2
      gi|10047224|dbj|AB010993.2|AB010581S2[10047224]
    • 7536: AB010581
      Homo sapiens hedgehog gene, exon 1
      gi|10047223|dbj|AB010581.2|AB010581S1[10047223]
    • 7537: SEG_AB010581S
      Homo sapiens hedgehog gene
      gi|0047222|dbj|SEG_AB010581S[10047222]
    • 7538: AX015117
      Sequence 8 from Patent WO9952943
      gi|10041220|emb|AX015117.1|AX015117[10041220]
    • 7539: AX015116
      Sequence 7 from Patent WO9952943
      gi|10041219|emb|AX015116.1|AX015116[10041219]
    • 7540: AX015115
      Sequence 6 from Patent WO9952943
      gi|10041218|emb|AX015115.1|AX015115[10041218]
    • 7541: AX015114
      Sequence 5 from Patent WO9952943
      gi|10041217|emb|AX015114.1|AX015114[10041217]
    • 7542: AX015113
      Sequence 4 from Patent WO9952943
      gi|10041216|emb|AX015113.1|AX015113[10041216]
    • 7543: AX015112
      Sequence 3 from Patent WO9952943
      gi|10041215|emb|AX015112.1|AX015112[10041215]
    • 7544: AX015111
      Sequence 2 from Patent WO9952943
      gi|10041214|emb|AX015111.1|AX015111[10041214]
    • 7545: AX015110
      Sequence 1 from Patent WO9952943
      gi|10041213|emb|AX015110.1|AX015110[10041213]
    • 7546: AF042080
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      mRNA, complete cds
      gi|2801556|gb|AF042080.1|AF042080[2801556]
    • 7547: AF255342
      Homo sapiens putative pheromone receptor V1RL1 long form (V1RL1) mRNA, complete
      cds
      gi|9988584|gb|AF255342.1|AF255342[9988584]
    • 7548: AF254747
      Homo sapiens ROR2 protein (ROR2) gene, exon 2
      gi|9664303|gb|AF254747.1|AF254747S1[9664303]
    • 7550: AJ295613
      Homo sapiens partial GHR gene for growth hormone receptor, exon 2
      gi|9968301|emb|AJ295613.1|HSA295613[9968301]
    • 7551: AJ278681
      Homo sapiens partial GHR gene for growth hormone receptor, exons 8-10
      gi|9968297|emb|AJ278681.1|HSA278681[9968297]
    • 7553: AF217963
      Homo sapiens NRAGE mRNA, complete cds
      gi|9963809|gb|AF217963.1|AF217963[9963809]
    • 7554: AF169970
      Homo sapiens complement receptor 1 (CR1) gene, CR1*SCR25-HUM5 allele, exon 29 and partial cds
      gi|9956947|gb|AF169970.1|AF169970[9956947]
    • 7555: AF169969
      Homo sapiens complement receptor 1 (CR1) gene, CR1*SCR25-HUM4 allele, exon 29 and partial cds
      gi|9956945|gb|AF169969.1|AF169969[9956945]
    • 7556: AB044402
      Homo sapiens mRNA for LTB4 receptor JULF2, complete cds
      gi|9081802|dbj|AB044402.1|AB044402[9081802]
    • 7557: U96190
      Homo sapiens p58 NK cell inhibitory receptor NKR-K7 mRNA, partial cds
      gi|2088618|gb|U96190.1|HSU96190[2088618]
    • 7558: U96189
      Homo sapiens p58 NK cell inhibitory receptor NKR-K6 mRNA, partial cds
      gi|2088616|gb|U96189.1|HSU96189[2088616]
    • 7559: U96188
      Homo sapiens p50 cell activatory receptor NKR-K1 mRNA, partial cds
      gi|2088614|gb|U96188.1|HSU96188[2088614]
    • 7560: AF251841
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exons 29, 30, and complete cds
      gi|9944844|gb|AF251841.1|F251818S24[9944844]
    • 7561: AF251840
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exons 27 and
      gi|9944843|gb|AF251840.1F251818S23[9944843]
    • 7562: AF251839
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 26
      gi|99448421|gb|AF251839.1|F251818S22[9944842]
    • 7563: AF251838
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 25
      gi|9944841|gb|AF251838.1|F251818S21[9944841]
    • 7564: AF251837
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exons 23 and
      gi|9944840|gb|AF251837.1F251818S20[9944840]
    • 7565: AF251836
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 22
      gi|9944839|gb|AF251836.1|F251818S19[9944839]
    • 7566: AF251835
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exons 20 and
      gi|9944838|gb|AF251835.1|F251818S18[9944838]
    • 7567: AF251834
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 19
      gi|9944837|gb|AF251834.1F251818S17[9944837]
    • 7568: AF251833
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 18
      gi|9944836|gb|AF251833.1|F251818S16[9944836]
    • 7569: AF251832
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 17
      gi|9944835|gb|AF251832.1|F251818S15[9944835]
    • 7570: AF251831
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 16
      gi|9944834|gb|AF251831.1|F251818S14[9944834]
    • 7571: AF251830
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 15
      gi|9944833|gb|AF251830.1|F251818S13[9944833]
    • 7572: AF251829
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 14
      gi|9944832|gb|AF251829.1|F251818S12[9944832]
    • 7573: AF251828
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 13
      gi|9944831|gb|AF251828.1|F251818S11[9944831]
    • 7574: AF251827
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exons 11 and
      gi|9944830|gb|AF251827.1|F251818S10[9944830]
    • 7575: AF251826
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exons 9 and
      gi|9944829|gb|AF251826.1|F251818S09[9944829]
    • 7576: AF251825
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 8
      gi|9944828|gb|AF251825.1|F251818S08[9944828]
    • 7577: AF251824
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 7
      gi|9944827|gb|AF251824.1F251818S07[9944827]
    • 7578: AF251823
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 6
      gi|9944826|gb|AF251823.1|F251818S06[9944826]
    • 7579: AF251822
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 5
      gi|9944825|gb|AF251822.1|F251818S05[9944825]
    • 7580: AF251821
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 4
      gi|9944824|gb|AF251821.1|F251818S04[9944824]
    • 7581: AF251820
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 3
      gi|9944823|gb|AF251820.1|F251818S03[9944823]
    • 7582: AF251819
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, exon 2
      gi|9944822|gb|AF251819.1|F251818S02[9944822]
    • 7583: AF251818
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, promoter region and exon 1
      gi|9944821|gb|AF251818.1|F251818S01[9944821]
    • 7584: AH009773
      Homo sapiens vitronectin receptor alpha polypeptide (ITGAV) gene, complete cds
      gi|9944820|gb|AH009773.1|SEG_F251818S[9944820]
    • 7585: AF189768
      Homo sapiens leukocyte immunoglobulin-like receptor 5 (LIR5) gene, complete cds
      gi|9930102|gb|AF189768.1|AF189768[9930102]
    • 7600: AJ245377
      Homo sapiens mRNA for 2B4 NK receptor homologue (h2B4 gene)
      gi|9621661|emb|AJ245377.1|HSA245377[9621661]
    • 7601: X07206
      H. sapiens TRGV10 gene, allele V10*A1
      gi|1848182|emb|X07206.1|HSTRGV10[1848182]
    • 7603: AF246974
      Homo sapiens toll-like receptor 9 (TLR9) mRNA, partial cds, alternatively spliced
      gi|9887086|gb|AF246974.1|AF246974[9887086]
    • 7604: AF246973
      Homo sapiens toll-like receptor 9 (TLR9) mRNA, partial cds, alternatively spliced
      gi|9887084|gb|AF246973.1|AF246973[9887084]
    • 7605: AF246972
      Homo sapiens toll-like receptor 9 (TLR9) mRNA, partial cds
      gi|9887082|gb|AF246972.1|AF246972[9887082]
    • 7606: AF215826
      Homo sapiens killer-cell Ig-like receptor KIR2DL4v1 (KIR2DL4) gene, KIR2DL4v1 allele, exon 3 and partial cds
      gi|9886965|gb|AF215826.1|AF215826[9886965]
    • 7607: AF215825
      Homo sapiens killer-cell Ig-like receptor KIR3DL1v (KIR3DL1) gene, KIR3DL1v allele, exon 3 and partial cds
      gi|9886963|gb|AF215825.1|AF215825[9886963]
    • 7608: AB008193
      Homo sapiens genes for leukotriene B4 receptor BLT2, leukotriene B4 receptor BLT1, complete cds
      gi|9229835|gb|AF008193.1|AF008193[9229835]
    • 7609: AB029892
      Homo sapiens hBLT2 mRNA for Leukotriene B4 receptor BLT2, complete cds
      gi|9186899|dbj|AB029892.1|AB029892[9186899]
    • 7610: AF211978
      Homo sapiens LENG11 mRNA, partial sequence
      gi|9885308|gb|AF211978.1|AF211978[9885308]
    • 7611: AF211977
      Homo sapiens LENG10 mRNA, partial sequence
      gi|9885307|gb|AF211977.1|AF211977[9885307]
    • 7612: AF211976
      Homo sapiens LENG9 mRNA, partial sequence
      gi|9885306|gb|AF211976.1|AF211976[9885306]
    • 7613: AF211975
      Homo sapiens LENG8 mRNA, variant C, partial sequence
      gi|9885305|gb|AF211975.1|AF211975[9885305]
    • 7614: AF211974
      Homo sapiens LENG8 mRNA, variant B, partial sequence
      gi|9885304|gb |AF211974.1|AF211974[9885304]
    • 7615: AF211973
      Homo sapiens LENG8 mRNA, variant A, partial sequence
      gi|9885303|gb|AF211973.1|AF211973[9885303]
    • 7616: AF211972
      Homo sapiens LENG7 mRNA, partial sequence
      gi|9885302|gb|AF211972.1|AF211972[9885302]
    • 7617: AF211971
      Homo sapiens LENG6 mRNA, partial sequence
      gi|9885301|gb|AF211971.1|AF211971[9885301]
    • 7618: AF211970
      Homo sapiens LENG5 mRNA, partial sequence
      gi|9885300|gb|AF211970.1|AF211970[9885300]
    • 7619: AF211969
      Homo sapiens LENG4 mRNA, partial sequence
      gi|9885299|gb|AF211969.1|AF211969[9885299]
    • 7620: AF211968
      Homo sapiens LENG3 mRNA, partial sequence
      gi|9885298|gb|AF211968.1|AF211968[9885298]
    • 7621: AF211967
      Homo sapiens LENG2 mRNA, partial sequence
      gi|9885297|gb|AF211967.1|AF211967[9885297]
    • 7622: AF211966
      Homo sapiens LENG1 protein (LENG1) mRNA, partial cds
      gi|9885295|gb|AF211966.1|AF211966[9885295]
    • 7624: AF262016
      Homo sapiens adrenergic receptor alpha-2A gene, complete cds
      gi|986478|gb|AF262016.2|AF262016[9864781]
    • 7626: AF242865
      Homo sapiens coxsackie virus and adenovirus receptor (CXADR) gene, exon 7 and complete cds
      gi|9858570|gb|AF242865.1|AF242862S4[9858570]
    • 7627: AF242864
      Homo sapiens coxsackie virus and adenovirus receptor (CXADR) gene, exons 2 through 6
      gi|9858569|gb|AF242864.1|AF242862S3[9858569]
    • 7629: AF242862
      Homo sapiens coxsackie virus and adenovirus receptor (CXADR) gene, exon 1
      gi|9858567|gb|AF242862.1|AF242862S1[9858567]
    • 7630: AH009718
      Homo sapiens coxsackie virus and adenovirus receptor (CXADR) gene, complete cds
      gi|9858566|gb|AH009718.1|SEG_AF242862S[9858566]
    • 7631: AF257210
      Homo sapiens G-protein coupled receptor HLWAR77 mRNA, complete cds
      gi|9309468|gb|AF257210.1|AF257210[9309468]
    • 7632: AF292403
      Homo sapiens type B natriuretic peptide receptor gene, promoter region and partial cds
      gi|9858187|gb|AF292403.1|AF292403[9858187]
    • 7633: AF288571
      Homo sapiens lymphoid enhancer factor-1 (LEF1) mRNA, complete cds
      gi|9858157|gb|AF288571.1|AF288571[9858157]
    • 7634: AF146747
      Homo sapiens cell surface receptor (PRV1) mRNA, complete cds
      gi|9857660|gb|AF146747.1|AF146747[9857660]
    • 7862: AF233092
      Homo sapiens lysophosphatidic acid G protein-coupled receptor 4 (EDG4) mRNA, complete cds
      gi|7243675|gb|AF233092.1|AF233092[7243675]
    • 7863: AF269144
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 10 and complete
      cds
      gi|9802369|gb|AF269144.1|F269135S10[9802369]
    • 7864: AF269143
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 9
      gi|9802368|gb|AF2691430.1F269135S09[9802368]
    • 7865: AF269142
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 8
      gi|9802367|gb|AF269142.1|F269135S08[9802367]
    • 7866: AF269141
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 7
      gi|9802366|gb|AF269141.1F269135S07[9802366]
    • 7867: AF269140
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 6
      gi|9802365|gb|AF269140.1|F269135S06[9802365]
    • 7868: AF269139
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 5
      gi|9802364|gb|AF269139.1|F269135S05[9802364]
    • 7869: AF269138
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 4
      gi|9802363|gb|AF269138.1F269135S04[9802363]
    • 7870: AF269137
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 3
      gi|9802362|gb|AF269137.1|F269135S03[9802362]
    • 7871: AF269136
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 2
      gi|980236|gb|AF269136.1|F269135S02[9802361]
    • 7872: AF269135
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 1
      gi|9802360|gb|AF269135.1|F269135S01[9802360]
    • 7873: AH009710
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, complete cds
      gi|9802359|gb|AH009710.1|SEG_F269135S[9802359]
    • 7874: AF211942
      Homo sapiens haplotype 1089 olfactory receptor (OR2H3) gene, partial cds
      gi|9798923|gb|AF211942.1|AF211942[9798923]
    • 7875: AF211941
      Homo sapiens haplotype 1037 olfactory receptor (OR2H3) gene, partial cds
      gi|9798921|gb|AF211941.1|AF211941[9798921]
    • 7876: AF211940
      Homo sapiens haplotype 1012 olfactory receptor (OR2H3) gene, partial cds
      gi|9798919|gb|AF211940.1|AF211940[9798919]
    • 7877: AF211939
      Homo sapiens haplotype 1013 olfactory receptor (OR2H3) gene, partial cds
      gi|9798917|gb|AF211939.1|AF211939[9798917]
    • 7878: AJ272029
      Homo sapiens partial CD30 gene for cytokine receptor CD30 and promoter region
      gi|9798449|emb|AJ272029.1|HSA272029[9798449]
    • 7880: AF101726
      Homo sapiens vasopressin receptor subtype 1b mRNA, complete cds
      gi|4336681|gb|AF101726.1|AF101726[4336681]
    • 7881: AF101725
      Homo sapiens vasopressin receptor subtype 1a mRNA, complete cds
      gi|4336679|gb|AF101725.1|AF101725[4336679]
    • 7882: AF101728
      Homo sapiens truncated vasopressin receptor type 2 mRNA, complete cds
      gi|4323606|gb|AF101728.1|AF101728[4323606]
    • 7883: AF101727
      Homo sapiens vasopressin receptor type 2 mRNA, complete cds
      gi|4323604|gb|AF101727.1|AF101727[4323604]
    • 7884: AF064078
      Homo sapiens insulin receptor-related receptor (INSRR) mRNA, partial cds
      gi|3152883|gb|AF064078.1|AF064078[3152883]
    • 7885: S82307
      Homo sapiens p65 mRNA, partial cds
      gi|1839613|gb|S82307.1|S82307[1839613]
    • 7886: S83176
      Homo sapiens calcium-sensing receptor long isoform (CASR) mRNA, partial cds
      gi|1836093|gb|S83176.1|S83176[1836093]
    • 7887: S82755
      Homo sapiens T cell receptor mRNA, partial cds
      gi|1835845|gb|S82755.1|S82755[1835845]
    • 7888: S82612
      Homo sapiens 5-hydroxytryptamine type 3AS receptor subunit mRNA, complete cds
      gi|1699437|gb|S82612.1|S82612[1699437]
    • 7891: AF238374
      Homo sapiens mutant fibroblast growth factor receptor 3 (FGFR3) mRNA, partial cds
      gi|9719331|gb|AF2383740.1|AF238374[9719331]
    • 7894: AJ400843
      Homo sapiens partial mRNA for immunoglobulin-like cell surface receptor FDF03-M14, soluble alternative form
      gi|9715838|emb|AJ400843.1|HSA400843[9715838]
    • 7895: AJ400842
      Homo sapiens partial mRNA for immunoglobulin-like cell surface receptor FDF03-dtm, soluble form
      gi|9715835|emb|AJ400842.1|HSA400842[9715835]
    • 7896: AJ400841
      Homo sapiens mRNA for immunoglobulin-like cell surface receptor FDF03
      gi|9715833|emb|AJ400841.1|HSA400841[9715833]
    • 8061: AJ005205
      Homo sapiens 5HT3 gene for serotonin 3 receptor
      gi|7019744|emb|AJ005205.2|HSA005205[7019744]
    • 8062: AB038269
      Homo sapiens mRNA for cysteinyl leukotriene CysLT2 receptor, complete cds; cDNA:
      PSEC0146 from clone PLACE1006979
      gi|9663957|dbj|AB038269.1|AB038269[9663957]
    • 8063: AJ278476
      Homo sapiens partial mRNA for transport-secretion protein 2.2, (TTS-2.2 gene)
      gi|9663152|emb|AJ278476.1|HSA278476[9663152]
    • 8064: AJ278475
      Homo sapiens partial mRNA for transport-secretion protein 2.1 (TTS-2.1 gene)
      gi|9663150|emb|AJ278475.1|HSA278475[9663150]
    • 8065: AF282693
      Homo sapiens inflammation-related G protein-coupled receptor EX33 (EX33) mRNA,
      complete cds
      gi|9652260|gb|AF282693.1|AF282693[9652260]
    • 8066: AF254409
      Homo sapiens scavenger receptor class B type III SR-BIII mRNA, partial cds
      gi|9651987|gb|AF254409.1|AF254409[9651987]
    • 8067: AF236117
      Homo sapiens G-protein coupled receptor EDG-7 mRNA, complete cds
      gi|9651838|gb|AF236117.1|AF236117[9651838]
    • 8068: AF287008
      Homo sapiens triggering receptor expressed on monocytes 1 (TREML) mRNA, complete
      cds
      gi|9624485|gb|AF287008.1|AF287008[9624485]
    • 8069: AF172171
      Homo sapiens toll-like receptor 4 (TLR4) gene, exon 4 and complete cds
      gi|9622356|gb|AF172171.1|HSTLR3[9622356]
    • 8070: AF172170
      Homo sapiens toll-like receptor 4 (TLR4) genie, exons 2 and 3
      gi|9622355|gb|AF172170.1|HSTLR2[9622355]
    • 8071: AF172169
      Homo sapiens toll-like receptor 4 (TLR4) gene, exon 1
      gi|9622354|gb|AF172169.1|HSTLR1[9622354]
    • 8072: AH009665
      Homo sapiens toll-like receptor 4 (TLR4) gene, complete cds
      gi|9622353|gb|AH009665.1|SEG_HSTLR[9622353]
    • 8073: AF165312
      Homo sapiens pre-T-cell receptor alpha chain (PTA) mRNA, alternatively spliced,
      complete cds
      gi|9621867|gb|AF165312.1|AF165312[9621867]
    • 8074: AJ245375
      Homo sapiens mRNA for PP35 act (h2B4 gene)
      gi|9621657|emb|AJ245375.1|HSA245375[9621657]
    • 8075: AF277230
      Homo sapiens seven transmembrane receptor BLTR2 (BLTR2) mRNA, complete cds
      gi|8896158|gb|AF277230.1|AF277230[8896158]
    • 8076: AF114491
      Homo sapiens EGF-like module EMR2 (EMR2) mRNA, complete cds
      gi|6650688|gb|AF114491.1|AF114491[6650688]
    • 8077: AF107259
      Homo sapiens chromosome 21q22.1 cosmid clone ICRFcA0552D2, complete sequence, containing part of the glutamate receptor gene GLUR5
      gi|4154320|gb|AF107259.1|AF107259[4154320]
    • 8078: AF107257
      Homo sapiens chromosome 21q22.1 PAC L12209, complete sequence
      gi|4106881|gb|AF107257.1|AF107257[4106881]
    • 8079: AZ081535
      p133B6#4 RPCI-6 Homo sapiens genomic, genomic survey sequence
      gi|9587541|gb|AZ081535.1|AZ081535[9587541]
    • 8081: AF285168
      Homo sapiens GABA-A receptor beta 1 subunit (GABRB1) gene, promoter and partial
      cds
      gi|9502261|gb|AF285168.1|AF285168[9502261]
    • 8126: AC018755
      Homo sapiens chromosome 19, BAC BC330783 (CIT-HSPC470E3), complete sequence
      gi|9454515|gb|AC018755.3|AC018755[9454515]
    • 8159: AF246303
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, exon 9 and complete cds
      gi|7417394|gb|AF246303.1|AF246296S8[7417394]
    • 8160: AF246302
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, exons 7 and 8
      gi|7417393|gb|AF246302.1|AF246296S7[7417393]
    • 8161: AF246301
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, exon 6
      gi|7417392|gb|AF246301.1|AF246296S6[7417392]
    • 8162: AF246300
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, exon 5
      gi|741739|gb|AF246300.1|AF246296S5[7417391]
    • 8163: AF246299
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, exon 4
      gi|7417390|gb|AF246299.1|AF246296S4[7417390]
    • 8164: AF246298
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, exon 3
      gi|7417389|gb|AF246298.1|AF246296S3[7417389]
    • 8165: AF246297
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, exon 2
      gi|7417388|gb|AF246297.1|AF246296S2[7417388]
    • 8166: AF246296
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, promoter and exon 1
      gi|7417387|gb|AF246296.1|AF246296S1[7417387]
    • 8167: AH009223
      Homo sapiens peroxisome proliferative activated receptor delta (PPARD) gene, complete cds
      gi|7417386|gb|AH009223.1|SEG_AF246296S[7417386]
    • 8168: U94888
      Homo sapiens CC-chemokine-binding receptor JAB61 mRNA, complete cds
      gi|2213808|gb|U94888.1|HSU94888[2213808]
    • 8169: AB040434
      Homo sapiens mRNA for hTROY, complete cds
      gi|9392329|dbj|AB040434.1|AB040434[9392329]
    • 8170: AJ272427
      Homo sapiens mRNA for frizzled homolog 3 (FZD3 gene)
      gi|7649448|emb|AJ272427.1|HSA272427[7649448]
    • 8173: U88356
      Homo sapiens receptor tyrosine kinase ErbB-3 (c-erbB-3) gene, exons 12, 13, 14, and partial cds
      gi|9294704|gb|U88356.1|HSCERBR3[9294704]
    • 8174: U88355
      Homo sapiens receptor tyrosine kinase ErbB-3 (c-erbB-3) gene, exon 10 and partial cds
      gi|9294703|gb|U88355.1|HSCERBR2[9294703]
    • 8175: U88354
      Homo sapiens receptor tyrosine kinase ErbB-3 (c-erbB-3) gene, exons 8 and 9
      gi|9294702|gb|U88354.1|HSCERBR1[9294702]
    • 8176: AB037533
      Homo sapiens HTR1F gene for 5-hydroxytryptamine (serotonin) receptor 1F, partial
      cds
      gi|6815236|dbj|AB037533.1|AB037533[6815236]
    • 8177: AB037513
      Homo sapiens HTR2A gene for 5-hydroxytryptamine (serotonin) receptor 2A, partial
      cds
      gi|6815196|dbj|AB037513.1|AB037513[6815196]
    • 8178: AF180301
      Homo sapiens corticotropin-releasing factor receptor variant id (CRHR1) mRNA, alternative splice product, complete cds
      gi|5815472|gb|AF180301.1|AF180301[5815472]
    • 8181: AF208111
      Homo sapiens truncated IL-17 receptor homolog precursor (EVI27) mRNA, complete
      cds
      gi|9246434|gb|AF208111.1|AF208111[9246434]
    • 8182: AF208110
      Homo sapiens IL-17 receptor homolog precursor (EVI27) mRNA, complete cds
      gi|9246432|gb|AF208110.1|AF208110[9246432]
    • 8183: M15222
      Homo sapiens T-cell receptor (TCRB) mRNA, partial cds
      gi|338893|gb|M15222.1|HUMTCBVO[338893]
    • 8189: AF263279
      Homo sapiens CD164 mRNA, complete cds
      gi|9230740|gb|AF263279.1|AF263279[9230740]
    • 8192: AF242874
      Homo sapiens neuromedin U receptor 2 (NMU2R) mRNA, complete cds
      gi|9082155|gb|AF242874.1|AF242874[9082155]
    • 8193: AF160477
      Homo sapiens Ig superfamily receptor LNIR precursor, mRNA, complete cds
      gi|9049507|gb|AF160477.1|AF160477[9049507]
    • 8194: AF058290
      Homo sapiens imidazoline receptor antisera-selected protein mRNA, partial cds
      gi|3493224|gb|AF058290.1|AF058290[3493224]
    • 8195: AF082516
      Homo sapiens I-1 receptor candidate protein mRNA, complete cds
      gi|3462806|gb|AF082516.1|AF082516[3462806]
    • 8211: X06031
      Homo sapiens partial T-cell receptor CD3-gamma gene, exon 6
      gi|36818|emb|X06031.1|HSTCR3G6[36818]
    • 8212: X06030
      Homo sapiens partial T-cell receptor CD3-gamma gene, exon 5
      gi|36816|emb|X06030.1|HSTCR3G5[36816]
    • 8213: X06029
      Homo sapiens partial T-cell receptor CD3-gamma gene exon 4
      gi|36814|emb|X06029.1|HSTCR3G4[36814]
    • 8214: X06027
      Homo sapiens partial CD3G gene, exon 2 (and joined mature peptide)
      gi|36811|emb|X06027.1|HSTCR3G2[36811]
    • 8216: Z30426
      H. sapiens gene for early lymphocyte activation antigen CD69, exon 1
      gi|525242|emb|Z30426.1|HSLACD691[525242]
    • 8302: AJ278605
      Homo sapiens BLT-2R gene for leukotriene B4 receptor 2
      gi|8919627|emb|AJ278605.1|HSA278605[8919627]
    • 8444: AF246925
      Homo sapiens haplotype 28 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|880984|gb|AF246925.1|AF246925[8809841]
    • 8445: AF246924
      Homo sapiens haplotype 27 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809840|gb|AF246924.1|AF246924[8809840]
    • 8446: AF246923
      Homo sapiens haplotype 26 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809839|gb|AF246923.1|AF246923[8809839]
    • 8447: AF246922
      Homo sapiens haplotype 24 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809838|gb|AF246922.1|AF246922[8809838]
    • 8448: AF246921
      Homo sapiens haplotype 23 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809837|gb|AF246921.1|AF246921[8809837]
    • 8449: AF246920
      Homo sapiens haplotype 22 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809836|gb|AF246920.1|AF246920[8809836]
    • 8450: AF246919
      Homo sapiens haplotype 21 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809835|gb|AF246919.1|AF246919[8809835]
    • 8451: AF246918
      Homo sapiens haplotype 20 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809834|gb|AF246918.1|AF246918[8809834]
    • 8452: AF246917
      Homo sapiens haplotype 19 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809833|gb|AF246917.1|AF246917[8809833]
    • 8452: AF246917
    • 8453: AF246916
      Homo sapiens haplotype 18 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809832|gb|AF246916.1|AF246916[8809832]
    • 8454: AF246915
      Homo sapiens haplotype 17 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809831|gb|AF246915.1|AF246915[8809831]
    • 8455: AF246914
      Homo sapiens haplotype 16 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809830|gb|AF246914.1|AF246914[8809830]
    • 8456: AF246913
      Homo sapiens haplotype 15 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809829|gb|AF246913.1|AF246913[8809829]
    • 8457: AF246912
      Homo sapiens haplotype 14 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809828|gb|AF246912.1|AF246912[8809828]
    • 8458: AF246911
      Homo sapiens haplotype 13 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809827|gb|AF246911.1|AF246911[8809827]
    • 8459: AF246910
      Homo sapiens haplotype 12 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809826|gb|AF246910.1|AF246910[8809826]
    • 8460: AF246909
      Homo sapiens haplotype 11 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809825|gb|AF246909.1|AF246909[8809825]
    • 8461: AF246908
      Homo sapiens haplotype 10 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809824|gb|AF246908.1|AF246908[8809824]
    • 8462: AF246907
      Homo sapiens haplotype 9 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809823|gb|AF246907.1|AF246907[8809823]
    • 8463: AF246906
      Homo sapiens haplotype 8 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809822|gb|AF246906.1|AF246906[8809822]
    • 8464: AF246905
      Homo sapiens haplotype 7 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809821|gb|AF246905.1|AF246905[8809821]
    • 8465: AF246904
      Homo sapiens haplotype 6 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809820|gb|AF246904.1|AF246904[8809820]
    • 8466: AF246903
      Homo sapiens haplotype 5 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809819|gb|AF246903.1|AF246903[8809819]
    • 8467: AF246902
      Homo sapiens haplotype 4 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809818|gb|AF246902.1|AF246902[8809818]
    • 8468: AF246901
      Homo sapiens haplotype 1 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809817|gb|AF246901.1|AF246901[8809817]
    • 8469: AF246900
      Homo sapiens haplotype 2 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809816|gb|AF246900.1|AF246900[8809816]
    • 8470: AF246899
      Homo sapiens haplotype 3 CC chemokine receptor 5 (CCR5) gene, partial sequence
      gi|8809815|gb|AF246899.1|AF246899[8809815]
    • 8471: AF210633
      Homo sapiens growth hormone receptor (GHR) gene, GHR-d3 allele, partial sequence
      gi|8809760|gb|AF210633.1|AF210633[8809760]
    • 8472: M22057
      Homo sapiens T-cell receptor epsilon (CD3E) gene, exon 5 and partial cds
      gi|339220|gb|M22057.1|HUMTCR3E[339220]
    • 8476: AF212311
      Homo sapiens interleukin 20 (IL20) mRNA, complete cds
      gi|8705219|gb|AF2123110.1|AF212311[8705219]
    • 8477: AF141334
      Homo sapiens placenta apolipoprotein B48 receptor type 2 (APOB48R) mRNA, complete cds
      gi|8699629|gb|AF141334.1|AF141334[8699629]
    • 8478: AF277379
      Homo sapiens vitamin D receptor-interacting protein complex component DRIP100 (DRIP100) mRNA, complete cds
      gi|8699627|gb|AF277379.1|AF277379[8699627]
    • 8480: AJ251962
      Homo sapiens partial TGF-beta III receptor gene
      gi|6634455|emb|AJ251962.1|HSA251962[6634455]
    • 8481: AJ251961
      Homo sapiens partial mRNA for betaglycan (TBR III gene)
      gi|6634453|emb|AJ251961.1|HSA251961[6634453]
    • 8483: AF062039
      Homo sapiens integrin alpha-2 subunit (ITGA2) gene, ITGA2-1 allele, partial cds
      gi|8574452|gb|AF062039.1|AF062039[8574452]
    • 8485: AF141333
      Homo sapiens apolipoprotein B48 receptor (APOB48R) gene, complete cds
      gi|8547065|gb|AF141333.1|AF141333[8547065]
    • 8486: AF141332
      Homo sapiens apolipoprotein B48 receptor (APOB48R) mRNA, complete cds
      gi|8547063|gb|AF141332.1|AF141332[8547063]
    • 8488: X56253
      Homo sapiens partial MPR46 gene for 46 kd mannose 6-phosphate receptor, exon 1 and join mRNA
      gi|34727|emb|X56253.1|HSMPR461[34727]
    • 8489: AF155912
      Homo sapiens growth hormone receptor (GHR) gene, exon 3 and partial cds
      gi|8037572|gb|AF155912.1|AF155912[8037572]
    • 8490: AF263744
      Homo sapiens erbb2-interacting protein ERBIN mRNA, complete cds
      gi|8572220|gb|AF263744.1|AF263744[8572220]
    • 8501: X56254
      Homo sapiens partial MPR46 gene for 46 kd mannose 6-phosphate receptor, exon 2 join CDS
      gi|34729|emb|X56254.1|HSMPR462[34729]
    • 8503: AB040801
      Homo sapiens mRNA for SREB3, complete cds
      gi|8467969|dbj|AB040801.1|AB040801[8467969]
    • 8504: AB040800
      Homo sapiens mRNA for SREB2, complete cds
      gi|8467967|dbj|AB040800.1|AB040800[8467967]
    • 8505: AB040799
      Homo sapiens mRNA for SREB1, complete cds
      gi|8467965|dbj|AB040799.1|AB040799[8467965]
    • 8506: AF187064
      Homo sapiens p75NTR-associated cell death executor (NADE) mRNA, complete cds
      gi|8452893|gb|AF187064.1|AF187064[8452893]
    • 8507: AF045606
      Homo sapiens C21orf4 mRNA, complete cds
      gi|8277249|gb|AF045606.2|AF045606[8277249]
    • 8508: AF204920
      Homo sapiens killer cell Ig-like receptor (KIR48) gene, KIR48b variant, exon 5
      gi|8248132|gb|AF204920.1|AF204918S3[8248132]
    • 8509: AF204919
      Homo sapiens killer cell Ig-like receptor (KIR48) gene, KIR48b variant, exon 4
      gi|8248131|gb|AF204919.1|AF204918S2[8248131]
    • 8510: AF204918
      Homo sapiens killer cell Ig-like receptor (KIR48) gene, KIR48b variant, exons 4
      and 3
      gi|8248130|gb|AF204918.1|AF204918S1[8248130]
    • 8511: AH009422
      Homo sapiens
      gi|8248129|gb|AH009422.1|SEG_AF204918S[8248129]
    • 8512: AF204917
      Homo sapiens killer cell Ig-like receptor (KIR48) gene, KIR48a variant, exon 5
      gi|8248128|gb|AF204917.1|AF204915S3[8248128]
    • 8513: AF204916
      Homo sapiens killer cell Ig-like receptor (KIR48) gene, KIR48a variant, exon 4
      gi|8248127|gb|AF204916.1|AF204915S2[8248127]
    • 8514: AF204915
      Homo sapiens killer cell Ig-like receptor (KIR48) gene, KIR48a variant, exons 2
      and 3
      gi|8248126|gb|AF204915.1|AF204915S1[8248126]
    • 8515: AH009421
      Homo sapiens
      gi|8248125|gb|AH009421.1|SEG_AF204915S[8248125]
    • 8516: AF204914
      Homo sapiens killer cell Ig-like receptor (KIR44) gene, KIR44b variant, exon 5
      gi|8248124|gb|AF204914.1|AF204912S3[8248124]
    • 8517: AF204913
      Homo sapiens killer cell Ig-like receptor (KIR44) gene, KIR44b variant, exon 4
      gi|8248123|gb|AF204913.1|AF204912S2[8248123]
    • 8518: AF204912
      Homo sapiens killer cell Ig-like receptor (KIR44) gene, KIR44b variant, exons 2
      and 3
      gi|8248122|gb|AF204912.1|AF204912S1[8248122]
    • 8519: AH009420
      Homo sapiens
      gi|8248121|gb|AH009420.1|SEG_AF204912S[8248121]
    • 8520: AF204911
      Homo sapiens killer cell Ig-like receptor (KIR44) gene, KIR44a variant, exon
      5
      gi|8248120|gb|AF204911.1|AF204909S3[8248120]
    • 8521: AF204910
      Homo sapiens killer cell Ig-like receptor (KIR44) gene, KIR44a variant, exon 4
      gi|8248119|gb|AF204910.1|AF204909S2[8248119]
    • 8522: AF204909
      Homo sapiens killer cell Ig-like receptor (KIR44) gene, KIR44a variant, exons
      2
      and 3
      gi|8248118|gb|AF204909.1|AF204909S1[8248118]
    • 8523: AH009419
      Homo sapiens
      gi|8248117|gb|AH009419.1|SEG_AF204909S[8248117]
    • 8524: AF204905
      Homo sapiens killer cell Ig-like receptor (KIR2DL5) gene, KIR2DL5.2 variant, partial sequence
      gi|8248112|gb|AF204905.1|AF204905[8248112]
    • 8525: AF204904
      Homo sapiens killer cell Ig-like receptor (KIR2DL5) gene, KIR2DL5.1 variant, partial cds
      gi|8248110|gb|AF204904.1|AF204904[8248110]
    • 8607: AF212842
      Homo sapiens immunoglobulin-like transcript 11 protein (ILT11) mRNA, partial cds
      gi|8163785|gb|AF212842.1|AF212842[8163785]
    • 8608: AF208237
      Homo sapiens 7-transmembrane G-protein coupled receptor 2 (GPR2) mRNA, complete
      cds
      gi|8118034|gb|AF208237.1|AF208237[8118034]
    • 8609: AF204903
      Homo sapiens killer-cell immunoglobulin-like receptor KIR2DL5.1 (KIR2DL5) mRNA,
      complete cds
      gi|8117976|gb|AF204903.1|AF204903[8117976]
    • 8610: AP001716
      Homo sapiens genomic DNA, chromosome 21q, section 60/105
      gi|7768717|dbj|AP001716.1|AP001716[7768717]
    • 8611: AP001705
      Homo sapiens genomic DNA, chromosome 21q, section 49/105
      gi|7768711|dbj|AP001705.1|AP001705[7768711]
    • 8612: AP001670
      Homo sapiens genomic DNA, chromosome 21q, section 14/105
      gi|7768690|dbj|AP001670.1|AP001670[7768690]
    • 8613: AP001717
      Homo sapiens genomic DNA, chromosome 21q, section 61/105
      gi|7768678|dbj|AP001717.1|AP001717[7768678]
    • 8616: AJ012074
      Homo sapiens VPAC1 receptor gene, 5′ end and promoter region
      gi|3758828|emb|AJ012074.1|HSA012074[3758828]
    • 8617: AF039906
      Homo sapiens cosmid D16B8, chromosome 21 3′ of IFNGR2
      gi|2914756|gb|AF039906.1|AF039906[2914756]
    • 8619: S77335
      Homo sapiens growth hormone receptor gene, partial cds
      gi|999143|gb|S77335.1|S77335[999143]
    • 8621: S75765
      Homo sapiens delta CCK-B gene, partial cds
      gi|913754|gb|S75765.1|S75765[913754]
    • 8624: S78717
      Homo sapiens ryanodine receptor (RYR1) gene, partial cds
      gi|244183|gb|S78717.1|S78717[244183]
    • 8625: X15266
      Homo sapiens gene for muscarinic acetylcholine receptor HM3
      gi|32323|emb|X15266.1|HSACM3[32323]
    • 8626: X15265
      Homo sapiens gene for muscarinic acetylcholine receptor M4
      gi|32321|emb|X15265.1|HSACM4[32321]
    • 8627: AF220542
      Homo sapiens FCRN protein gene, complete cds
      gi|8101614|gb|AF220542.1|AF220542[8101614]
    • 8629: AF073924
      Homo sapiens putative taste receptor HTR2 mRNA, partial cds
      gi|8100088|gb|AF073924.1|AF073924[8100088]
    • 8630: D88437
      Homo sapiens mRNA for G-protein coupled receptor SALPR, complete cds
      gi|7340885|dbj|D88437.1|D88437[7340885]
    • 8631: AB032369
      Homo sapiens MIST mRNA, partial cds
      gi|8099156|dbj|AB032369.1|AB032369[8099156]
    • 8632: AF167555
      Homo sapiens TAJ-alpha mRNA, complete cds
      gi|8071643|gb|AF167555.1|AF167555[8071643]
    • 8633: AF002982
      Homo sapiens killer cell receptor (KIR103) mRNA, allele ASD2, complete cds
      gi|2443483|gb|AF002982.1|AF002982[2443483]
    • 8634: AF002981
      Homo sapiens killer cell receptor (KIR103) mRNA, allele ASD1, complete cds
      gi|2443481|gb|AF002981.1|AF002981[2443481]
    • 8635: AF002980
      Homo sapiens killer cell receptor (KIR103) mRNA, allele AS, complete cds
      gi|2443479|gb|AF002980.1|AF002980[2443479]
    • 8636: AF002979
      Homo sapiens killer cell receptor (KIR103) mRNA, allele LP, complete cds
      gi|2443477|gb|AF002979.1|AF002979[2443477]
    • 8637: AH005453
      Homo sapiens chromosome 19 clone 4 map 19q13.4
      gi|2228790|gb|AH005453.1|SEG_HSKIR[2228790]
    • 8638: AF003123
      Homo sapiens killer cell inhibitory receptor (KIR-103AS) gene, exon 8 and complete cds
      gi|2228789|gb|AF003123.1|HSKIR8[2228789]
    • 8639: AF003122
      Homo sapiens killer cell inhibitory receptor (KIR-103AS) gene, exon 7
      gi|2228788|gb|AF003122.1|HSKIR7[2228788]
    • 8640: AF003121
      Homo sapiens killer cell inhibitory receptor (KIR-103AS) gene, exon 6
      gi|2228787|gb|AF003121.1|HSKIR6[2228787]
    • 8641: AF003120
      Homo sapiens killer cell inhibitory receptor (KIR-103AS) gene, exon 5
      gi|2228786|gb|AF003120.1|HSKIR5[2228786]
    • 8642: AF003119
      Homo sapiens killer cell inhibitory receptor (KIR-103AS) gene, exon 4
      gi|2228785|gb|AF003119.1|HSKIR4[2228785]
    • 8643: AF003118
      Homo sapiens killer cell inhibitory receptor (KIR-103AS) gene, exon 3
      gi|2228784|gb|AF003118.1|HSKIR3[2228784]
    • 8644: AF003117
      Homo sapiens killer cell inhibitory receptor (KIR-103AS) gene, exon 2
      gi|2228783|gb|AF003117.1|HSKIR2[2228783]
    • 8645: AF003116
      Homo sapiens killer cell inhibitory receptor (KIR-103AS) gene, exon 1
      gi|2228782|gb|AF003116.1|HSKIR1[2228782]
    • 8646: AF196329
      Homo sapiens triggering receptor expressed on monocytes 1 mRNA, complete cds
      gi|8050526|gb|AF196329.1|AF196329[8050526]
    • 8647: AF167342
      Homo sapiens membrane interleukin 1 receptor accessory protein (IL1RAP) gene, exon 12 and complete cds, alternatively spliced
      gi|8050498|gb|AF167342.1|F167333S10[8050498]
    • 8648: AF167341
      Homo sapiens membrane interleukin 1 receptor accessory protein (IL1RAP) gene, exons 10 and 11
      gi|8050497|gb|AF167341.1|F167333S09[8050497]
    • 8649: AF167340
      Homo sapiens soluble interleukin 1 receptor accessory protein (IL1RAP) gene, exon 8, alternative exons 9 and complete cds, alternatively spliced
      gi|8050496|gb|AF167340.1|F167333S08[8050496]
    • 8650: AF167339
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP) gene, exon 7
      gi|8050495|gb|AF167339.1|F167333S07[8050495]
    • 8651: AF167338
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP) gene, exon 6
      gi|8050494|gb|AF167338.1|F167333S06[8050494]
    • 8652: AF167337
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP) gene, exon 5
      gi|8050493|gb|AF167337.1|F167333S05[8050493]
    • 8653: AF167336
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP) gene, exon 4
      gi|8050492|gb|AF167336.1F167333S04[8050492]
    • 8654: AF167335
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP) gene, exon 3
      gi|8050491|gb|AF167335.1|F167333S03[8050491]
    • 8655: AF167334
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP) gene, exon 2
      gi|8050490|gb|AF167334.1|F167333S02[8050490]
    • 8656: AF167333
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP) gene, exon 1
      gi|8050489|gb|AF167333.1|F167333S01[8050489]
    • 8657: AH009309
      Homo sapiens interleukin 1 receptor accessory protein (IL1RAP) gene, complete cds, alternatively spliced
      gi|8050488|gb|AH009309.1|SEG_F167333S[8050488]
    • 8658: AF167343
      Homo sapiens soluble interleukin-1 receptor accessory protein (IL1RAP) mRNA, complete cds
      gi|8050486|gb|AF167343.1|AF167343[8050486]
    • 8659: AF213457
      Homo sapiens triggering receptor expressed on myeloid cells 2 mRNA, complete cds
      gi|7800156|gb|AF213457.1|AF213457[7800156]
    • 8661: AF233281
      Homo sapiens CC chemokine receptor (CCBP2) gene, complete cds
      gi|7274391|gb|AF233281.1|AF233281[7274391]
    • 8662: AF189259
      Homo sapiens GABA-A receptor theta subunit (THETA) mRNA, complete cds
      gi|7861735|gb|AF189259.1|AF189259[7861735]
    • 8663: AF176832
      Homo sapiens low density lipoprotein receptor related protein-deleted in tumor
      (LRPDIT) mRNA, complete cds
      gi|7861732|gb|AF176832.1|AF176832[7861732]
    • 8664: AH001455
      Homo sapiens protooncogene protein (c-erb-2) gene, partial cds
      gi|182164|gb|AH001455.1|SEG_HUMERB2[182164]
    • 8665: M11767
      Homo sapiens protooncogene protein (c-erb-2) gene, exon 7 and partial cds
      gi|182163|gb|M11767.1|HUMERB27[182163]
    • 8666: M11766
      Homo sapiens protooncogene protein (c-erb-2) gene, exon 6
      gi|182162|gb|M11766.1|HUMERB26[182162]
    • 8667: M11765
      Homo sapiens protooncogene protein (c-erb-2) gene, exon 5
      gi|118216|gb|M11765.1|HUMERB25[182161]
    • 8668: M11764
      Homo sapiens protooncogene protein (c-erb-2) gene, exon 4
      gi|182160|gb|M11764.1|HUMERB24[182160]
    • 8669: M11763
      Homo sapiens protooncogene protein (c-erb-2) gene, exon 3
      gi|182159|gb|M11763.1|HUMERB23[182159]
    • 8670: M11762
      Homo sapiens protooncogene protein (c-erb-2) gene, exon 2
      gi|182158|gb|M11762.1|HUMERB22[182158]
    • 8671: M11761
      Homo sapiens protooncogene protein (c-erb-2) gene, exon 1
      gi|182157|gb|M11761.1|HUMERB21[182157]
    • 8674: AC068948
      Homo sapiens chromosome 19, cosmid R28371 (LLNL-R244D7), complete sequence
      gi|7798735|gb|AC068948.1|AC068948[7798735]
    • 8675: AF060231
      Homo sapiens herpesvirus entry protein C (HVEC) mRNA, complete cds
      gi|3242792|gb|AF060231.1|AF060231[3242792]
    • 8676: Z24459
      H. sapiens MTCP1 gene, exons 2A to 7 (and joined mRNA)
      gi|2252491|emb|Z24459.1|HSMTCP12A[2252491]
    • 8677: AB006200
      Homo sapiens gene for parathyroid hormone/parathyroid hormone-related protein receptor, exon1, partial sequence
      gi|7770088|dbj|AB006200.1|AB006200[7770088]
    • 8693: AB023493
      Homo sapiens mRNA for preproapelin, complete cds
      gi|6009585|dbj|AB023493.1|AB023493[6009585]
    • 8697: M55336
      Homo sapiens oncogene tyrosine protein kinase receptor (trk2) mRNA, partial cds
      gi|339913|gb|M55336.1|HUMTRK2[339913]
    • 8701: AB028741
      Homo sapiens mRNA for syntaxin 18, complete cds
      gi|7707423|dbj|AB028741.1|AB028741[7707423]
    • 8702: U27478
      Homo sapiens angiotensin II type 2 receptor (AT2) gene, partial cds
      gi|1143833|gb|U27478.1|HSU27478[1143833]
    • 8707: M81774
      Homo sapiens T-cell receptor alpha (TCRB) mRNA, partial cds
      gi|186224|gb|M81774.1|HUMIGTCACA[186224]
    • 8708: S70782
      Homo sapiens alpha adrenergic receptor subtype alpha 1a mRNA, complete cds
      gi|547219|gb|S70782.1|S70782[547219]
    • 8709: S70057
      Homo sapiens cholecystokinin B receptor mRNA, complete cds
      gi|546748|gb|S70057.1|S70057[546748]
    • 8711: S70123
      Homo sapiens low density lipoprotein receptor mRNA, partial cds
      gi|546107|gb|S70123.1|S70123[546107]
    • 8712: S56143
      Homo sapiens A1 adenosine receptor mRNA, complete cds
      gi|298327|gb|S56143.1|S56143[298327]
    • 8715: S57793
      Homo sapiens luteinizing hormone receptor mRNA, complete cds
      gi|236050|gb|S57793.1|S57793[236050]
    • 8722: AF202640
      Homo sapiens orphan G-protein coupled receptor (GPRC5B) mRNA, complete cds
      gi|7682556|gb|AF202640.1|AF202640[7682556]
    • 8723: AF211154
      AF211154 Clontech HL1008b Homo sapiens cDNA, mRNA sequence
      gi|7677996|gb|AF211154.1|AF211154[7677996]
    • 8724: AF211153
      AF211153 Clontech HL1008b Homo sapiens cDNA, mRNA sequence
      gi|7677995|gb|AF211153.1|AF211153[7677995]
    • 8729: AF145440
      Homo sapiens CC chemokine receptor 9B (CCR9) mRNA, alternatively spliced, complete cds
      gi|7673010|gb|AF145440.1|AF145440[7673010]
    • 8730: AF145439
      Homo sapiens CC chemokine receptor 9A (CCR9) mRNA, alternatively spliced, complete cds
      gi|7673008|gb|AF145439.1|AF145439[7673008]
    • 8731: AF129170
      Homo sapiens apolipoprotein E receptor 2 gene, exon 6b and partial cds, alternatively spliced
      gi|7672339|gb|AF129170.1|AF129169S2[7672339]
    • 8732: AF129169
      Homo sapiens apolipoprotein E receptor 2 gene, exon 6a and partial cds, alternatively spliced
      gi|7672338|gb|AF129169.1|AF129169S1[7672338]
    • 8733: AH009264
      Homo sapiens apolipoprotein E receptor 2 and apolipoprotein E receptor 2 genes,
      partial cds
      gi|7672337|gb|AH009264.1|SEG_AF129169S[7672337]
    • 8812: AB039723
      Homo sapiens FZD3 mRNA for WNT receptor frizzled-3, complete cds
      gi|7670051|dbj|AB039723.1|AB039723[7670051]
    • 8813: AL353940
      Homo sapiens mRNA; cDNA DKFZp761P1010 (from clone DKFZp761P1010)
      gi|7669978|emb|AL353940.1|HSM802647[7669978]
    • 8814: AC067969
      Homo sapiens chromosome 19, cosmid R26839 (LLNL-R228D1), complete sequence
      gi|7656699|gb|AC067969.1|AC067969[7656699]
    • 8815: AF236081
      Homo sapiens orphan G-protein coupled receptor GPR72 (GPR72) mRNA, complete cds
      gi|7248881|gb|AF236081.1|AF236081[7248881]
    • 8819: AC004416
      Homo sapiens BAC clone CTB-13N12 from 7q31.2, complete sequence
      gi|2979585|gb|AC004416.1|AC004416[2979585]
    • 8820: AF056020
      Homo sapiens chemokine receptor CCR5 (CCR5) gene, CCR5-delta32 allele, partial
      cds
      gi|7648496|gb|AF056020.1|AF056020[7648496]
    • 8821: AF056019
      Homo sapiens mutant chemokine receptor CCR5 (CCR5) gene, CCR5-delta32 allele, partial cds
      gi|7648494|gb|AF056019.1|AF056019[7648494]
    • 8822: AF052244
      Homo sapiens mutant chemokine receptor CCR5 (CCR5) gene, CCR5-delta32 allele, partial cds
      gi|7648492|gb|AF052244.1|AF052244[7648492]
    • 8824: AF068288
      Homo sapiens HDCME31P mRNA, complete cds
      gi|7643783|gb|AF068288.1|AF068288[7643783]
    • 8825: AF186022
      Homo sapiens B lymphocyte adapter protein BAM32 (BAM32) mRNA, complete cds
      gi|6503077|gb|AF186022.1|AF186022[6503077]
    • 8826: AB002168
      Homo sapiens gene for vitamin D receptor, exon 9 and complete cds
      gi|5736651|dbj|AB002168.1|AB00215S12[5736651]
    • 8827: AB002167
      Homo sapiens gene for vitamin D receptor, exon 8
      gi|5736591|dbj|AB002167.1|AB00215S11[5736591]
    • 8828: AB002166
      Homo sapiens gene for vitamin D receptor, exon 7
      gi|5736588|dbj|AB002166.1|AB00215S10[5736588]
    • 8829: AB002165
      Homo sapiens gene for vitamin D receptor, exon 6
      gi|5736585|dbj|AB002165.1|AB00215S09[5736585]
    • 8830: AB002164
      Homo sapiens gene for vitamin D receptor, exon 5
      gi|5736582|dbj|AB002164.1|AB00215S08[5736582]
    • 8831: AB002163
      Homo sapiens gene for vitamin D receptor, exon 4
      gi|5736579|dbj|AB002163.1|AB00215S07[5736579]
    • 8832: AB002162
      Homo sapiens gene for vitamin D receptor, exon 3
      gi|5736575|dbj|AB002162.1|AB00215S06[5736575]
    • 8833: AB002161
      Homo sapiens gene for vitamin D receptor, exon 2
      gi|5736571|dbj|AB002161.1|AB00215S05[5736571]
    • 8834: AB002160
      Homo sapiens gene for vitamin D receptor, exon 1c, 5′ non-coding region
      gi|5736566|dbj|AB002160.1|AB00215S04[5736566]
    • 8835: AB002159
      Homo sapiens gene for vitamin D receptor, exon 1b, 5′ non-coding region
      gi|5736562|dbj|AB002159.1|AB00215S03[5736562]
    • 8839: AB005647
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 22 and complete cds
      gi|5139788|dbj|AB005647.1|AB00562S23[5139788]
    • 8840: AB005646
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 21
      gi|5139787|dbj|AB005646.1|AB00562S22[5139787]
    • 8841: AB005645
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 20
      gi|5139786|dbj|AB005645.1|AB00562S21[5139786]
    • 8842: AB005644
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 19
      gi|5139785|dbj|AB005644.1|AB00562S20[5139785]
    • 8843: AB005643
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 18
      gi|5139784|dbj|AB005643.1|AB00562S19[5139784]
    • 8844: AB005642
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 17
      gi|5139783|dbj|AB005642.1|AB00562S18[5139783]
    • 8845: AB005641
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 16
      gi|5139782|dbj|AB005641.1|AB00562S17[5139782]
    • 8846: AB005640
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 15
      gi|5139781|dbj||AB005640.1|AB00562S16[5139781]
    • 8847: AB005639
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 14
      gi|5139780|dbj|AB005639.1|AB00562S15[5139780]
    • 8848: AB005638
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 13
      gi|5139779|dbj|AB005638.1|AB00562S14[5139779]
    • 8849: AB005637
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 12
      gi|5139778|dbj|AB005637.1|AB00562S13[5139778]
    • 8850: AB005636
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 11
      gi|5139777|dbj|AB005636.1|AB00562S12[1L39777]
    • 8851: AB005635
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 10
      gi|5139776|dbj|AB005635.1|AB00562S11[5139776]
    • 8852: AB005634
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 9
      gi|5139775|dbj|AB005634.1|AB00562S10[5139775]
    • 8853: AB005633
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 8
      gi|5139774|dbj|AB005633.1|AB00562S09[5139774]
    • 8854: AB005632
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 7
      gi|5139773|dbj|AB005632.1|AB00562S08[5139773]
    • 8855: AB005631
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 6
      gi|5139772|dbj|AB005631.1|AB00562S07[5139772]
    • 8856: AB005630
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 5
      gi|5139771|dbj|AB005630.1|AB00562S06[5139771]
    • 8857: AB005629
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 4
      gi|5139770|dbj|AB005629.1|AB00562S05[5139770]
    • 8858: AB005628
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 3
      gi|5139769|dbj|AB005628.1|AB00562S04[5139769]
    • 8859: AB005627
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 2
      gi|5139768|dbj|AB005627.1|AB00562S03[5139768]
    • 8860: AB005626
      Homo sapiens gene for atrial natriuretic peptide Btype receptor, exon 1
      gi|5139767|dbj|AB005626.1|AB00562S02[5139767]
    • 8862: AF030335
      Homo sapiens purinergic P2Y11 receptor (P2Y11) mRNA, complete cds
      gi|2674119|gb|AF030335.1|AF030335[2674119]
    • 8863: AF003522
      Homo sapiens Delta mRNA, complete cds
      gi|2197068|gb|AF003522.1|AF003522[2197068]
    • 8864: AF003521
      Homo sapiens Jagged 2 mRNA, complete cds
      gi|2197066|gb|AF003521.1|AF003521[2197066]
    • 8865: AF068292
      Homo sapiens HDCMA39P mRNA, partial cds
      gi|7634778|gb|AF068292.1|AF068292[7634778]
    • 8868: AH007819
      Homo sapiens 5-hydroxytryptamine 2B receptor (HTR2B) gene, complete cds
      gi|5442455|gb|AH007819.2|SEG_HSHTR2B[5442455]
    • 8869: AF156158
      Homo sapiens 5-hydroxytryptamine 2B receptor (HTR2B) gene, exon 1
      gi|5442454|gb|AF156158.2|HSHTR2B1[5442454]
    • 8870: AF156160
      Homo sapiens 5-hydroxytryptamine 2B receptor (HTR2B) gene, exon 3 and complete
      cds
      gi|5070703|gb|AF156160.1|HSHTR2B3[5070703]
    • 8871: AF156159
      Homo sapiens 5-hydroxytryptamine 2B receptor (HTR2B) gene, exon 2
      gi|5070702|gb|AF156159.1|HSHTR2B2[5070702]
    • 8872: AB041713
      Homo sapiens fp gene for prostaglandin F2alpha receptor, exon 1 and 2, partial
      cds
      gi|7619988|dbj|AB041713.1|AB041713[7619988]
    • 8873: AF041811
      Homo sapiens ETS related protein-growth factor receptor tyrosine kinase fusion
      proteins (ETV6-NTRK3 fusion) mRNA, partial cds
      gi|6274523|gb|AF041811.2|AF041811[6274523]
    • 8874: AF172453
      Homo sapiens opioid growth factor receptor mRNA, complete cds
      gi|7595306|gb|AF172453.1|AF172453[7595306]
    • 8875: AF172452
      Homo sapiens opioid growth factor receptor mRNA, complete cds
      gi|7595304|gb|AF172452.1|AF172452[7595304]
    • 8876: AF172451
      Homo sapiens opioid growth factor receptor mRNA, complete cds
      gi|7595302|gb|AF172451.1|AF172451[7595302]
    • 8877: AF172450
      Homo sapiens opioid growth factor receptor mRNA, complete cds
      gi|7595300|gb|AF172450.1|AF172450[7595300]
    • 8878: AF172449
      Homo sapiens clone 127 opioid growth factor receptor mRNA, complete cds
      gi|7595298|gb|AF172449.1|AF172449[7595298]
    • 8879: D49394
      Homo sapiens mRNA for serotonin 5-HT3 receptor, complete cds
      gi|681913|dbj|D49394.1|HUMS5HT3RA[681913]
    • 8880: AB041395
      Homo sapiens CHRM3 gene for muscarinic acetylcholine receptor m3, complete cds
      gi|7592980|dbj|AB041395.1|AB041395[7592980]
    • 8881: AB041391
      Homo sapiens CHRM2 gene for muscarinic acetylcholine receptor m2, partial cds
      gi|7592971|dbj|AB041391.1|AB041391[7592971]
    • 8882: AB041384
      Homo sapiens gene for histamine H2 receptor, complete cds
      gi|7592957|dbj|AB041384.1|AB041384[7592957]
    • 8883: AB041380
      Homo sapiens gene for histamine H1 receptor, complete cds
      gi|7592949|dbj|AB041380.1|AB041380[7592949]
    • 8884: AB041373
      Homo sapiens HTR1E gene for 5-hydroxytryptamine (serotonin) receptor 1E, partial
      cds
      gi|7592934|dbj|AB041373.1|AB041373[7592934]
    • 8885: AB041370
      Homo sapiens HTR1B gene for 5-hydroxytryptamine (serotonin) receptor 1B, complete cds
      gi|7592928|dbj|AB041370.1|AB041370[7592928]
    • 8887: AB033598
      Homo sapiens gene for melatonin 1b receptor, exon 2 and complete cds
      gi|7209599|dbj|AB033598.1|AB033597S2[7209599]
    • 8888: AB033597
      Homo sapiens gene for melatonin 1b receptor, exon 1
      gi|7209598|dbj|AB033597.1|AB033597S1[7209598]
    • 8889: SEG_AB033597S
      Homo sapiens gene for melatonin 1b receptor
      gi|7209597|dbj|SEG_AB033597S[7209597]
    • 8890: D85606
      Homo sapiens gene for cholecystokinin type-A receptor, complete cds
      gi|7008026|dbj|D85606.1D85606[7008026]
    • 8891: SEG_AB019480S
      Homo sapiens NTRK1 gene for TRKA
      gi|6492387|dbj|SEG_AB019480S[6492387]
    • 8892: AB019485
      Homo sapiens NTRK1 gene for TRKA, exon 8-14
      gi|6492386|dbj|AB019485.2|AB019480S6[6492386]
    • 8893: SEG_AB029932S
      Homo sapiens hMel1a gene for melatonin 1a receptor
      gi|6045084|dbj|SEG_AB029932S[6045084]
    • 8894: AB029933
      Homo sapiens hMel1a gene for melatonin 1a receptor, exon 2 and complete cds
      gi|6045083|dbj|AB029933.1|AB029932S2[6045083]
    • 8895: AB029932
      Homo sapiens hMel1a gene for melatonin 1a receptor, exon 1
      gi|6045082|dbj|AL029932.1|AB029932S1[6045082]
    • 8896: AB026584
      Homo sapiens gene for endothelial protein C receptor, complete cds
      gi|5837963|dbj|AB026584.2|AB026584[5837963]
    • 8897: AB017444
      Homo sapiens gene for lectin-like oxidized LDL receptor, exon 6
      gi|5821166|dbj|AB017444.1|AB017444[5821166]
    • 8898: AB017443
      Homo sapiens gene for lectin-like oxidized LDL receptor, exon 5
      gi|5821165|dbj|AB017443.1|AB017443[5821165]
    • 8899: AB017442
      Homo sapiens gene for lectin-like oxidized LDL receptor, exon 4
      gi|5821164|dbj|AB017442.1|AB017442[5821164]
    • 8900: AB017441
      Homo sapiens gene for lectin-like oxidized LDL receptor, exon 3
      gi|5821163|dbj|AB017441.1|AB017441[5821163]
    • 8901: AB017440
      Homo sapiens gene for lectin-like oxidized LDL receptor, exon 2
      gi|5821162|dbj|AB017440.1|AB017440[5821162]
    • 8902: AB017439
      Homo sapiens gene for lectin-like oxidized LDL receptor, exon 1
      gi|5821161|dbj|AB017439.1|AB017439[5821161]
    • 8903: AB019488
      Homo sapiens NTRK1 gene for TRKA, exon 17 and complete cds
      gi|3869111|dbj|AB019488.1|AB019480S9[3869111]
    • 8904: AB019487
      Homo sapiens NTRK1 gene for TRKA, exon 16
      gi|3869110|dbj|AB019487.1|AB019480S8[3869110]
    • 8905: AB019486
      Homo sapiens NTRK1 gene for TRKA, exon 15
      gi|3869109|dbj|AB019486.1|AB019480S7[3869109]
    • 8906: AB019484
      Homo sapiens NTRK1 gene for TRKA, exon 7
      gi|3869107|dbj|AB019484.1|AB019480S5[3869107]
    • 8907: AB019483
      Homo sapiens NTRK1 gene for TRKA, exon 5 and 6
      gi|3869106|dbj|AB019483.1|AB3019480S4[3869106]
    • 8908: AB019482
      Homo sapiens NTRK1 gene for TRKA, exon 4
      gi|3869105|dbj|AB019482.1|AB019480S3[3869105]
    • 8909: AB019481
      Homo sapiens NTRK1 gene for TRKA, exon 2,3
      gi|3869104|dbj|AB019481.1|AB019480S2[3869104]
    • 8910: AB019480
      Homo sapiens NTRK1 gene for TRKA, exon 1
      gi|3869103|dbj|AB019480.1|AB019480S1[3869103]
    • 8911: SEG_AB01471S
      Homo sapiens DR5 gene
      gi|3721877|dbj|SEG_AB01471S[3721877]
    • 8912: AB014718
      Homo sapiens DR5 gene, exon 9 and complete cds
      gi|3721876|dbj|AB014718.1|AB01471S9[3721876]
    • 8913: AB014717
      Homo sapiens DR5 gene, exon 8
      gi|3721875|dbj|AB014717.1|AB301471S8[3721875]
    • 8914: AB014716
      Homo sapiens DR5 gene, exon 7
      gi|3721874|dbj|AB014716.1|AB01471S7[3721874]
    • 8915: AB014715
      Homo sapiens DR5 gene, exon 6
      gi|3721873|dbj|AB014715.1|AB01471S6[3721873]
    • 8916: AB3014714
      Homo sapiens DR5 gene, exon 5
      gi|3721872|dbj|AB014714.1|AB01471S5[3721872]
    • 8917: AB014713
      Homo sapiens DR5 gene, exon 4
      gi|3721871|dbj|AB014713.1|AB01471S4[3721871]
    • 8918: AB014712
      Homo sapiens DR5 gene, exon 3
      gi|3721870|dbj|AB014712.1|AB01471S3[3721870]
    • 8919: AB014711
      Homo sapiens DR5 gene, exon 2
      gi|3721869|dbj|AB014711.1|AB01471S2[3721869]
    • 8920: AB014710
      Homo sapiens DR5 gene, exon 1, partial sequence
      gi|3721868|dbj|AB014710.1|AB01471S1[3721868]
    • 8921: SEG_AB01047S
      Homo sapiens gene for natriuretic peptide A type receptor
      gi|3297985|dbj|SEG_AB01047S[3297985]
    • 8922: AB010491
      Homo sapiens gene for natriuretic peptide A type receptor, exon 22 and complete
      cds
      gi|3297984|dbj|AB010491.1|AB01047S22[3297984]
    • 8923: AB010490
      Homo sapiens gene for natriuretic peptide A type receptor, exon 21
      gi|3297983|dbj|AB010490.1|AB01047S21[3297983]
    • 8924: AB010489
      Homo sapiens gene for natriuretic peptide A type receptor, exon 20
      gi|3297982|dbj|AB010489.1|AB01047S20[3297982]
    • 8925: AB010488
      Homo sapiens gene for natriuretic peptide A type receptor, exon 19
      gi|3297981|dbj|AB010488.1|AB01047S19[3297981]
    • 8926: AB010487
      Homo sapiens gene for natriuretic peptide A type receptor, exon 18
      gi|3297980|dbj|AB010487.1|AB01047S18[3297980]
    • 8927: AB010486
      Homo sapiens gene for natriuretic peptide A type receptor, exon 17
      gi|3297979|dbj|AB010486.1|AB01047S17[3297979]
    • 8928: AB010485
      Homo sapiens gene for natriuretic peptide A type receptor, exon 16
      gi|3297978|dbj|AB010485.1|AB01047S16[3297978]
    • 8929: AB010484
      Homo sapiens gene for natriuretic peptide A type receptor, exon 15
      gi|3297977|dbj|AB010484.1|AB01047S15[3297977]
    • 8930: AB010483
      Homo sapiens gene for natriuretic peptide A type receptor, exon 14
      gi|3297976|dbj|AB010483.1|AB01047S14[3297976]
    • 8931: AB010482
      Homo sapiens gene for natriuretic peptide A type receptor, exon 13
      gi|3297975|dbj|AB010482.1|AB01047S13[3297975]
    • 8932: AB010481
      Homo sapiens gene for natriuretic peptide A type receptor, exon 12
      gi|3297974|dbj|AB010481.1|AB01047S12[3297974]
    • 8933: AB010480
      Homo sapiens gene for natriuretic peptide A type receptor, exon 11
      gi|3297973|dbj|AB010480.1|AB01047S11[3297973]
    • 8934: AB010479
      Homo sapiens gene for natriuretic peptide A type receptor, exon 10
      gi|3297972|dbj|AB010479.1|AB01047S10[3297972]
    • 8935: AB010478
      Homo sapiens gene for natriuretic peptide A type receptor, exon 9
      gi|3297971|dbj|AB010478.1|AB01047S09[3297971]
    • 8936: AB010477
      Homo sapiens gene for natriuretic peptide A type receptor, exon 8
      gi|3297970|dbj|AB010477.1|AB01047S08[3297970]
    • 8937: AB010476
      Homo sapiens gene for natriuretic peptide A type receptor, exon 7
      gi|3297969|dbj|AB010476.1|AB01047S07[3297969]
    • 8938: AB010475
      Homo sapiens gene for natriuretic peptide A type receptor, exon 6
      gi|3297968|dbj|AB010475.1|AB01047S06[3297968]
    • 8939: AB010474
      Homo sapiens gene for natriuretic peptide A type receptor, exon 5
      gi|3297967|dbj|AB010474.1|AB01047S05[3297967]
    • 8940: AB010473
      Homo sapiens gene for natriuretic peptide A type receptor, exon 4
      gi|3297966|dbj|AB010473.1|AB01047S04[3297966]
    • 8941: AB010472
      Homo sapiens gene for natriuretic peptide A type receptor, exon 3
      gi|3297965|dbj|AB010472.1|AB01047S03[3297965]
    • 8942: AB010471
      Homo sapiens gene for natriuretic peptide A type receptor, exon 2
      gi|3297964|dbj|AB010471.1|AB01047S02[3297964]
    • 8943: AB010470
      Homo sapiens gene for natriuretic peptide A type receptor, exon 1, partial sequence
      gi|3297963|dbj|AB010470.1|AB01047S01[3297963]
    • 8944: AB008681
      Homo sapiens gene for activin receptor type IIB, complete cds
      gi|2760152|dbj|AB008681.1|AB008681[2760152]
    • 8945: SEG_AB005521S
      Homo sapiens ppar gamma gene for peroxisome proliferator activated-receptor gamma
      gi|2605496|dbj|SEG_AB005521S[2605496]
    • 8946: AB005526
      Homo sapiens ppar gamma gene for peroxisome proliferator activated-receptor gamma, eoxn 6 and complete cds
      gi|2605495|dbj|AB005526.1|AB005521S6[2605495]
    • 8947: AB005525
      Homo sapiens ppar gamma gene for peroxisome proliferator activated-receptor gamma, exon 5
      gi|2605494|dbj|AB005525.1|AB005521S5[2605494]
    • 8948: AB005524
      Homo sapiens ppar gamma gene for peroxisome proliferator activated-receptor gamma, exon 4
      gi|2605493|dbj|AB005524.1|AB005521S4[2605493]
    • 8949: AB005523
      Homo sapiens ppar gamma gene for peroxisome proliferator activated-receptor gamma, exon 3
      gi|2605492|dbj|AB005523.1|AB005521S3[2605492]
    • 8950: AB005522
      Homo sapiens ppar gamma gene for peroxisome proliferator activated-receptor gamma, exon 2
      gi|2605491|dbj|AB005522.1|AB005521S2[2605491]
    • 8951: AB005521
      Homo sapiens ppar gamma gene for peroxisome proliferator activated-receptor gamma, exon 1
      gi|2605490|dbj|AB005521.1|AB005521S1[2605490]
    • 8954: AB002059
      Homo sapiens DNA for Human P2XM, complete cds
      gi|2350848|dbj|AB002059.1|AB002059[2350848]
    • 8955: SEG_D86389S
    • 8955: D86407
      Homo sapiens DNA for apoER2
      gi|2344801|dbj||SEG_D86389S[2344801]
    • 8956: D86407
      Homo sapiens DNA for apoER2, complete cds, and exon 19
      gi|2344800|dbj|D86407.1|D86389S19[2344800]
    • 8957: D86406
      Homo sapiens DNA for apoER2, exon 18
      gi|2344799|dbj|D86406.1|D86389S18[2344799]
    • 8958: D86405
      Homo sapiens DNA for apoER2, exon 17
      gi|2344798|dbj|D86405.1|D86389S17[2344798]
    • 8959: D86404
      Homo sapiens DNA for apoER2, exon 16
      gi|2344797|dbj|D586404.1|D8.6389S16[2344797]
    • 8960: D86403
      Homo sapiens DNA for apoER2, exon 15
      gi|2344796|dbj|D86403.1|D86389S15[2344796]
    • 8961: D86402
      Homo sapiens DNA for apoER2, exon 14
      gi|2344795|dbj|D586402.1D86389S14[2344795]
    • 8962: D86401
      Homo sapiens DNA for apoER2, exon 13
      gi|2344794|dbj|D586401.1|D86389S13[2344794]
    • 8963: D86400
      Homo sapiens DNA apoER2, exon 12
      gi|2344793|dbj|D86400.1|D86389S12[2344793]
    • 8964: D86399
      Homo sapiens DNA for apoER2, exon 11
      gi|2344792|dbj|D586399.1|D86389S11[2344792]
    • 8965: D86398
      Homo sapiens DNA for apoER2, exon 10
      gi|2344791|dbj|D586398.1|D86389S10[2344791]
    • 8966: D86397
      Homo sapiens DNA for apoER2, exon 9
      gi|2344790|dbj|D586397.1|D86389S09[2344790]
    • 8967: D86396
      Homo sapiens DNA for apoER2, exon 8
      gi|2344789|dbj|D86396.1|D86389S08[2344789]
    • 8968: D86395
      Homo sapiens DNA for apoER2, exon 7
      gi|2344788|dbj|D586395.1|D86389S07[2344788]
    • 8969: D86394
      Homo sapiens DNA for apoER2, exon 6
      gi|2344787|dbj|D86394.1|D86389S06[2344787]
    • 8970: D86393
      Homo sapiens DNA for apoER2, exon 5
      gi|2344786|dbj|D86393.1|D86389S05[2344786]
    • 8971: D86392
      Homo sapiens DNA for apoER2, exon 4
      gi|2344785|dbj|D86392.1|D86389S04[2344785]
    • 8972: D86391
      Homo sapiens DNA for apoER2, exon 3
      gi|2344784|dbj|D586391.1|D86389S03[2344784]
    • 8973: D86390
      Homo sapiens DNA for apoER2, exon 2
      gi|2344783|dbj|D86390.1|D86389S02[2344783]
    • 8974: D86389
      Homo sapiens DNA for apoER2, exon 1
      gi|2344782|dbj|D86389.1|D86389S01[2344782]
    • 8975: D86096
      Human DNA for prostaglandin EP3 receptor subtype, complete cds
      gi|2114186|dbj|D86096.1|D86087S10[2114186]
    • 8976: D86095
      Human DNA for prostaglandin E receptor EP3 subtype, exon 9
      gi|2114185|dbj|D86095.1|D86087S09[2114185]
    • 8977: D86094
      Human DNA for prostaglandin E receptor EP3 subtype, exon 8
      gi|2114184|dbj|D86094.1|D86087S08[2114184]
    • 8978: D86093
      Human DNA for prostaglandin E receptor EP3 subtype, exon 7
      gi|2114183|dbj|D586093.1|D86087S07[2114183]
    • 8979: D86092
      Human DNA for prostaglandin E receptor EP3 subtype, exon 6
      gi|2114182|dbj|D586092.1|D86087S06[2114182]
    • 8980: D86091
      Human DNA for prostaglandin E receptor EP3 subtype, exon 5
      gi|2114181|dbj|D86091.1|D86087S05[2114181]
    • 8981: D86090
      Human DNA for prostaglandin E receptor EP3 subtype, exon 4
      gi|21141800 dbj|D86090.1|D86087S04[2114180]
    • 8982: D86089
      Human DNA for prostaglandin E receptor EP3 subtype, exon 3
      gi|2114179|dbj|D86089.1|D86087S03[2114179]
    • 8983: D86088
      Human DNA for prostaglandin E receptor EP3 subtype, exon 2
      gi|2114178|dbj|D86088.1|D86087S02[2114178]
    • 8984: D86087
      Human DNA for prostaglandin E receptor EP3 subtype, exon 1
      gi|2114177|dbj|D586087.1|D86087S01[2114177]
    • 8985: SEG_D49555S
      Homo sapiens DNA for gastric inhibitory polypeptide receptor
      gi|1805368|dbj||SEG_D49555S[1805368]
    • 8986: D85376
      Human DNA for thyrotropin-releasing hormone receptor, exon 3 and copmplete cds
      gi|1616933|dbj|D585376.1|D85375S2[1616933]
    • 8987: D85375
      Human DNA for thyrotropin-releasing hormon receptor, exon 1, 2
      gi|1616932|dbj|D585375.1D85375S1[1616932]
    • 8988: D49559
      Human DNA for gastric inhibitory polypeptide receptor, exon 13 and 14, complete
      cds
      gi|1088442|dbj|D549559.1|D49555S5[1088442]
    • 8989: D49558
      Human DNA for gastric inhibitory polypeptide receptor, exon 5, 6, 7, 8, 9, 10,
      11 and 12
      gi|1088441|dbj|D549558.1|D49555S4[1088441]
    • 8990: D49557
      Human DNA for gastric inhibitory polypeptide receptor, exon 3 and 4
      gi|1088440|dbj|D549557.1D49555S3[1088440]
    • 8991: D49556
      Homo sapiens DNA for gastric inhibitory polypeptide receptor, exon 2
      gi|1088439|dbj|D549556.1D49555S2[1088439]
    • 8992: D49555
      Homo sapiens DNA for gastric inhibitory polypeptide receptor, exon 1
      gi|1088438|dbj|D549555.1|D49555S1[1088438]
    • 8993: D64016
      Human gene for vascular endothelial growth factor receptor, promoter and exon 1
      gi|1088437|dbj|D564016.1|HUMES[1088437]
    • 8994: D38128
      Homo sapiens IP gene for prostacyclin receptor, exon 3
      gi|1019364|dbj|D538128.1|HUMIP2[1019364]
    • 8995: D38127
      Human IP gene for prostacyclin receptor, exon 1 and exon 2
      gi|1019362|dbj|D538127.1|HUMIP1[1019362]
    • 8996: D37965
      Human mRNA for PDGF receptor beta-like tumor suppressor (PRLTS), complete cds
      gi|807818|dbj|D537965.1|HUMPRLTS[807818]
    • 8997: D50017
      Human DNA for alpha-platelet-derived growth factor receptor, exon 23
      gi|767797|dbj|D550017.1|D50001S17[767797]
    • 8998: D50016
      Human DNA for alpha-platelet-derived growth factor receptor, exon 22
      gi|767796|dbj|D550016.1|D50001S16[767796]
    • 8999: DS0015
      Human DNA for alpha-platelet-derived growth factor receptor, exon 20 and 21
      gi|767795|dbj|D50015.1|D50001S15[767795]
    • 9000: D50014
      Human DNA for alpha-platelet-derived growth factor receptor, exon 19
      gi|767794|dbj|D550014.1|D50001S14[767794]
    • 9001: D50013
      Human DNA for alpha-platelet-derived growth factor receptor, exon 18
      gi|767793|dbj|D550013.1|D50001S13[767793]
    • 9002: D50012
      Human DNA for alpha-platelet-derived growth factor receptor, exon 17
      gi|767792|dbj|D550012.1D50001S12[767792]
    • 9003: D50011
      Human DNA for alpha-platelet-derived growth factor receptor, exon 16
      gi|767791|dbj|D550011.1|D50001S11[767791]
    • 9004: D50010
      Human DNA for alpha-platelet-derived growth factor receptor, exon 15
      gi|767790|dbj|D550010.1|D50001S10[767790]
    • 9005: D50009
      Human DNA for alpha-platelet-derived growth factor receptor, exon 14
      gi|767789|dbj|D550009.1|D50001S09[767789]
    • 9006: D50008
      Human DNA for alpha-platelet-derived growth factor receptor, exon 13
      gi|767788|dbj|D550008.1|D50001S08[767788]
    • 9007: D50007
      Human DNA for alpha-platelet-derived growth factor receptor, exon 11 and 12
      gi|767787|dbj|D550007.1|D50001S07[767787]
    • 9008: D50006
      Human DNA for alpha-platelet-derived growth factor receptor, exon 6-10
      gi|767786|dbj|D550006.1|D50001S06[767786]
    • 9009: D50005
      Human DNA for alpha-platelet-derived growth factor receptor, exon 5
      gi|767785|dbj|D550005.1|D50001S05[767785]
    • 9010: D50004
      Human DNA for alpha-platelet-derived growth factor receptor, exon 4
      gi|767784|dbj|D550004.1D50001S04[767784]
    • 9011: D50003
      Human DNA for alpha-platelet-derived growth factor receptor, exon 3
      gi|767783|dbj|D550003.1|D50001S03[767783]
    • 9012: D50002
      Human DNA for alpha-platelet-derived growth factor receptor, exon 2
      gi|767781|dbj|D550002.1D50001S02[767781]
    • 9013: D50001
      Human DNA for alpha-platelet-derived growth factor receptor, exon 1
      gi|767780|dbj|D550001.1|D50001S01[767780]
    • 9014: D31793
      Human CD40 ligand (CD40L) gene, 5′ flanking region and exon 1
      gi|662386|dbj|D531793.1|HUMCD40L1[662386]
    • 9015: D28768
      Homo sapiens leukocyte DNA for Ah receptor, exon 1
      gi|567941|dbj|D528768.1|HUMAHRP[567941]
    • 9016: D28769
      Human HOX12 and RAGE genes, complete cds
      gi|561657|dbj|D528769.1|HUMHOXRAGE[561657]
    • 9017: D31708
      Human DNA for Ah-receptor, exon 1
      gi|538228|dbj|D531708.1|HUMAHR[538228]
    • 9019: D26535
      Human gene for dihydrolipoamide succinyltransferase, complete cds (exon 1-15)
      gi|537349|dbj|D26535.1|HUMDS[537349]
    • 9020: SEG_HUMTA2R
      Homo sapiens gene for thromboxane A2 receptor
      gi|488600|dbj|SEGHUMTA2R[488600]
    • 9021: D15056
      Homo sapiens gene for thromboxane A2 receptor, exon 3
      gi|441173|dbj|D515056.1|HUMTA2R4[441173]
    • 9022: D15055
      Homo sapiens gene for thromboxane A2 receptor, exon 2
      gi|441172|dbj|D515055.1|HUMTA2R3[441172]
    • 9023: D15054
      Homo sapiens gene for thromboxane A2 receptor, exon 1b (promoter region II)
      gi|441171|dbj|D515054.1|HUMTA2R2[441171]
    • 9024: D15053
      Homo sapiens gene for thromboxane A2 receptor, exon 1 (promoter region I)
      gi|441170|dbj|D515053.1|HUMTA2R1[441170]
    • 9025: D21219
      Human CCKBR gene for cholecystokinin-B receptor/gastrin receptor, exon 2-5, partial cds
      gi|416225|dbj|D521219.1|HUMCCKBR2[416225]
    • 9026: D21218
      Human CCKBR gene for cholecystokinin-B receptor/gastrin receptor, exon 1
      gi|416224|dbj|D21218.1|HUMCCKBR1[416224]
    • 9027: D16532
      Human gene for very low density lipoprotein receptor, exon 19
      gi|407219|dbj|D16532.1|HUMVLDLR19[407219]
    • 9028: D16531
      Human gene for very low density lipoprotein receptor, exon 18
      gi|407218|dbj|D16531.1|HUMVLDLR18[407218]
    • 9029: D16530
      Huma gene for very low density lipoprotein receptor, exon 17
      gi|407217|dbj|D16530.1|HUMVLDLR17[407217]
    • 9030: D16529
      Human gene for very low density lipoprotein receptor, exon 16
      gi|407216|dbj|D516529.1|HUMVLDLR16[407216]
    • 9031: D16528
      Human gene for very low density lipoprotein receptor, exon 15
      gi|407215|dbj|D516528.1|HUMVLDLR15[407215]
    • 9032: D16527
      Human gene for very low density lipoprotein receptor, exon 14
      gi|407214|dbj|D516527.1|HUMVLDLR14[407214]
    • 9033: D16526
      Human gene for very low density lipoprotein receptor, exon 13
      gi|407213|dbj|D516526.1|HUMVLDLR13[407213]
    • 9034: D16525
      Human gene for very low density lipoprotein receptor, exon 12
      gi|407212|dbj|D516525.1|HUMVLDLR12[407212]
    • 9035: D16524
      Human gene for very low density lipoprotein receptor, exon 11
      gi|407211|dbj|D516524.1|HUMVLDLR11[407211]
    • 9036: D16523
      Human gene for very low density lipoprotein receptor, exon 10
      gi|407210|dbj|D516523.1|HUMVLDLR10[407210]
    • 9037: D16522
      Human gene for very low density lipoprotein receptor, exon 9
      gi|407209|dbj|D516522.1|HUMVLDLR09[407209]
    • 9038: D16520
      Human gene for very low density lipoprotein receptor, exon 8
      gi|407208|dbj|D516520.1|HUMVLDLR08[407208]
    • 9039: D16518
      Human gene for very low density lipoprotein receptor, exon 7
      gi|407207|dbj|D516518.1|HUMVLDLR07[407207]
    • 9040: D16516
      Human gene for very low density lipoprotein receptor, exon 6
      gi|407206|dbj|D516516.1|HUMVLDLR06[407206]
    • 9041: D16514
      Human gene for very low density lipoprotein receptor, exon 5
      gi|407205|dbj|D516514.1|HUMVLDLR05[407205]
    • 9042: D16512
      Human gene for very low density lipoprotein receptor, exon 4
      gi|407204|dbj|D516512.1|HUMVLDLR04[407204]
    • 9043: D16510
      Human gene for very low density lipoprotein receptor, exon 3
      gi|407203|dbj|D516510.1|HUMVLDLR03[407203]
    • 9044: D16508
      Human gene for very low density lipoprotein receptor, exon 2
      gi|407202|dbj|D516508.1|HUMVLDLR02[407202]
    • 9045: D16495
      Human gene for very low density lipoprotein receptor, 5′flanking and exon 1
      gi|407201|dbj|D516495.1|HUMVLDLR01[407201]
    • 9046: D13168
      Human gene for endothelin-B receptor (hET-BR), exon 7
      gi|285924|dbj|D513168.1|HUMHETBR7[285924]
    • 9047: D13167
      Human gene for endothelin-B receptor (hET-BR), exon 6
      gi|285923|dbj|D513167.1|HUMHETBR6[285923]
    • 9048: D13166
      Human gene for endothelin-B receptor (hET-BR), exon 5
      gi|285922|dbj|D513166.1|HUMHETBR5[285922]
    • 9049: D13165
      Human gene for endothelin-B receptor (hET-BR), exon 4
      gi|285921|dbj|D513165.1|HUMHETBR4[285921]
    • 9050: D13164
      Human gene for endothelin-B receptor (hET-BR), exon 3
      gi|285920|dbj|D513164.1|HUMHETBR3[285920]
    • 9051: D13163
      Human gene for endothelin-B receptor (hET-BR), exon 2
      gi|285919|dbj|D13163.1|HUMHETBR2[285919]
    • 9052: D13162
      Human gene for endothelin-B receptor (hET-BR), exon 1
      gi|285918|dbj|D13162.1|HUMHETBR1[285918]
    • 9053: D10604
      Human midkine gene, complete cds
      gi|219928|dbj|D10604.1|HUMMK[219928]
    • 9054: D11151
      Human DNA for endothelin-A receptor, exon 8 and 3′ flanking region
      gi|219628|dbj|D511151.1|HUMETAR8[219628]
    • 9055: D11150
      Human DNA for endothelin-A receptor, exon 7
      gi|219627|dbj|D511150.1|HUMETAR7[219627]
    • 9056: D11149
      Human DNA for endothelin-A receptor, exon 6
      gi|219626|dbj|D511149.1|HUMETAR6[219626]
    • 9057: D11148
      Human DNA for endothelin-A receptor, exon 5
      gi|219625|dbj|D511148.1|HUMETAR5[219625]
    • 9058: D11147
      Human DNA for endothelin-A receptor, exon 4
      gi|219624|dbj|D511147.1|HUMETAR4[219624]
    • 9059: D11146
      Human DNA for endothelin-A receptor, exon 3
      gi|219623|dbj|D511146.1|HUMETAR3[219623]
    • 9060: D11145
      Human DNA for endothelin-A receptor, exon 2
      gi|219622|dbj|D511145.1|HUMETAR2[219622]
    • 9061: D11144
      Human DNA for endothelin-A receptor, 5′ flanking region and exon 1
      gi|219621|dbj|D511144.1|HUMETAR1[219621]
    • 9063: AF215981
      Homo sapiens CC chemokine receptor 10 (CCR10) mRNA, complete cds
      gi|7546844|gb|AF215981.1|AF215981[7546844]
    • 9066: AF065440
      Homo sapiens low density lipoprotein receptor-related protein II (LRP2) gene, exon 1 and partial cds
      gi|7534311|gb|AF065440.2|AF065440[7534311]
    • 9068: AF228458
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 10 and partial
      cds
      gi|7530451|gb|AF228458.1|AF228450S9[7530451]
    • 9069: AF228457
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 9
      gi|7530450|gb|AF228457.1|AF228450S8[7530450]
    • 9070: AF228456
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 8
      gi|7530449|gb|AF228456.1|AF228450S7[7530449]
    • 9071: AF228455
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 7
      gi|7530448|gb|AF228455.1|AF228450S6[7530448]
    • 9072: AF228454
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 6
      gi|7530447|gb|AF228454.1|AF228450S5[7530447]
    • 9073: AF228453
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 5
      gi|7530446|gb|AF228453.1|AF228450S4[7530446]
    • 9074: AF228452
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 4
      gi|7530445|gb|AF228452.1|AF228450S3[7530445]
    • 9075: AF228451
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 3
      gi|7530444|gb|AF228451.1|AF228450S2[7530444]
    • 9076: AF228450
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, exon 2
      gi|7530443|gb|AF228450.1|AF228450S1[7530443]
    • 9077: AH009226
      Homo sapiens GABAA receptor gamma 3 subunit (GABRG3) gene, partial cds
      gi|7530442|gb|AH009226.1|SEG_AF228450S[7530442]
    • 9078: AJ272208
      Homo sapiens mRNA for IL-1 receptor accessory protein-like 2 (IL1RAPL-2 gene)
      gi|7530096|emb|AJ272208.1|HSA272208[7530096]
    • 9081: AF056085
      Homo sapiens GABA-B receptor mRNA, complete cds
      gi|3719225|gb|AF056085.1|AF056085[3719225]
    • 9083: AF161081
      Homo sapiens activating receptor PILRbeta mRNA, complete cds
      gi|5817856|gb|AF161081.1|AF161081[5817856]
    • 9084: AF161080
      Homo sapiens inhibitory receptor PILRalpha mRNA, complete cds
      gi|5817854|gb|AF161080.1|AF161080[5817854]
    • 9085: AF228449
      Homo sapiens gamma-aminobutyric acid receptor alpha 5 subunit (GABRA5) gene, exon 10 and partial cds
      gi|7417243|gb|AF228449.1|AF228447S3[7417243]
    • 9086: AF228448
      Homo sapiens gamma-aminobutyric acid receptor alpha 5 subunit (GABRA5) gene, exon 8 and partial cds
      gi|7417242|gb|AF228448.1|AF228447S2[7417242]
    • 9087: AF228447
      Homo sapiens gamma-aminobutyric acid receptor alpha 5 subunit (GABRA5) gene, exons 5, 6, and partial cds
      gi|7417241|gb|AF228447.1|AF228447S1[7417241]
    • 9088: AH009221
      Homo sapiens gamma-aminobutyric acid receptor alpha 5 subunit (GABRA5), gamma-aminobutyric acid receptor alpha 5 subunit (GABRA5), and gamma-aminobutyric acid receptor alpha 5 subunit (GABRA5) genes, partial cds
      gi|7417240|gb|AH009221.1|SEG_AF228447S[7417240]
    • 9089: AF198052
      Homo sapiens EVH1 domain binding protein mRNA, complete cds
      gi|7416992|gb|AF198052.1|AF198052[7416992]
    • 9091: AF159278
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 17
      gi|7406946|gb|AF159278.1F159262S17[7406946]
    • 9092: AF159277
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 16 and complete cds, alternatively spliced
      gi|7406945|gb|AF159277.1|F159262S16[7406945]
    • 9093: AF159276
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 15
      gi|7406944|gb|AF159276.1|F159262S15[7406944]
    • 9094: AF159275
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 14
      gi|7406943|gb|AF159275.1|F159262S14[7406943]
    • 9095: AF159274
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 13
      gi|7406942|gb|AF159274.1|F159262S13[7406942]
    • 9096: AF159273
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 12
      gi|7406941|gb|AF159273.1F159262S12[7406941]
    • 9097: AF159272
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 11
      gi|7406940|gb|AF159272.1|F159262S11[7406940]
    • 9098: AF159271
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 10
      gi|7406939|gb|AF159271.1|F159262S10[7406939]
    • 9099: AF159270
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 9
      gi|7406938|gb|AF159270.1|F159262S09[7406938]
    • 9100: AF159269
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 8
      gi|7406937|gb|AF159269.1F159262S08[7406937]
    • 9101: AF159268
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 7
      gi|7406936|gb|AF159268.1|F159262S07[7406936]
    • 9102: AF159267
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 6
      gi|7406935|gb|AF159267.1|F159262S06[7406935]
    • 9103: AF159266
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 5
      gi|7406934|gb|AF159266.1|F159262S05[7406934]
    • 9104: AF159265
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 4
      gi|7406933|gb|AF159265.1|F159262S04[7406933]
    • 9105: AF159264
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 3
      gi|7406932|gb|AF159264.1F159262S03[7406932]
    • 9106: AF159263
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 2
      gi|7406931|gb|AF159263.1|F159262S02[7406931]
    • 9107: AF159262
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, exon 1
      gi|7406930|gb|AF159262.1|F159262S01[7406930]
    • 9108: AH009217
      Homo sapiens glutamate receptor subunit 3 (GRIA3) gene, complete cds, alternatively spliced
      gi|7406929|gb|AH009217.1|SEG_F159262S[7406929]
    • 9109: AF176812
      Homo sapiens dopamine receptor D2longer mRNA, complete cds
      gi|7381415|gb|AF176812.1|AF176812[7381415]
    • 9112: AF193507
      Homo sapiens chemokine receptor (CCR11) gene, complete cds
      gi|736334|gb|AF193507.1|AF193507[7363341]
    • 9113: AF105239
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 9
      and complete cds
      gi|7363319|gb|AF105239.1|KIR3DL9[7363319]
    • 9114: AF105238
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 8
      gi|7363318|gb|AF105238.1|KIR3DL8[7363318]
    • 9115: AF105237
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 7
      gi|7363317|gb|AF105237.1|KIR3DL7[7363317]
    • 9116: AF105236
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 6
      gi|7363316|gb|AF105236.1|KIR3DL6[7363316]
    • 9117: AF105235
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 5
      gi|7363315|gb|AF105235.1|KIR3DL5[7363315]
    • 9118: AF105234
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 4
      gi|7363314|gb|AF105234.1|KIR3DL4[7363314]
    • 9119: AF105233
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 3
      gi|7363313|gb|AF105233.1|KIR3DL3[7363313]
    • 9120: AF105232
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 2
      gi|7363312|gb|AF105232.1|KIR3DL2[7363312]
    • 9121: AF105231
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, exon 1
      gi|736331|gb|AF105231.1|KIR3DL1[7363311]
    • 9122: AH009212
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL) gene, complete
      cds
      gi|7363310|gb|AH009212.1|SEG_KIR3DL[7363310]
    • 9123: AF104856
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon 9
      and complete cds
      gi|7363308|gb|AF104856.1|HSKCIRV9[7363308]
    • 9124: AF104855
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon 8
      gi|7363307|gb|AF104855.1|HSKCIRV8[7363307]
    • 9125: AF104854
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon 7
      gi|7363306|gb|AF104854.1|HSKCIRV7[7363306]
    • 9126: AF104853
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon 6
      gi|7363305|gb|AF104853.1|HSKCIRV6[7363305]
    • 9127: AF104852
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon 5
      gi|7363304|gb|AF104852.1|HSKCIRV5[7363304]
    • 9128: AF104851
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon 4
      gi|7363303|gb|AF104851.1|HSKCIRV4[7363303]
    • 9129: AF104850
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon 3
      gi|7363302|gb|AF104850.1|HSKCIRV3[7363302]
    • 9130: AF104849
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon 2
      gi|7363301|gb|AF104849.1|HSKCIRV2[7363301]
    • 9131: AF104848
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, exon
      1
      gi|7363300|gb|AF104848.1|HSKCIRV1[7363300]
    • 9132: AH009211
      Homo sapiens killer cell immunoglobulin receptor variant (KIR3DL1) gene, complete cds
      gi|7363299|gb|AH009211.1|SEG_HSKCIRV[7363299]
    • 9136: AF130742
      AF130742 Homo sapiens LNCaP prostate cancer Homo sapiens cDNA, mRNA sequence
      gi|7330628|gb|AF130742.1|AF130742[7330628]
    • 9137: AF130741
      AF130741 Homo sapiens LNCaP prostate cancer Homo sapiens cDNA, mRNA sequence
      gi|7330627|gb|AF130741.1|AF130741[7330627]
    • 9138: AF130740
      AF130740 Homo sapiens LNCaP prostate cancer Homo sapiens cDNA, mRNA sequence
      gi|7330626|gb|AF130740.1|AF130740[7330626]
    • 9139: AF130739
      AF130739 Homo sapiens LNCaP prostate cancer Homo sapiens cDNA, mRNA sequence
      gi|7330625|gb|AF130739.1|AF130739[7330625]
    • 9140: AF130738
      AF130738 Homo sapiens LNCaP prostate cancer Homo sapiens cDNA, mRNA sequence
      gi|7330624|gb|AF130738.1|AF130738[7330624]
    • 9141: AF130737
      AF130737 Homo sapiens LNCaP prostate cancer Homo sapiens cDNA, mRNA sequence
      gi|7330623|gb|AF130737.1|AF130737[7330623]
    • 9142: AF130743
      AF130743 Homo sapiens LNCaP prostate cancer Homo sapiens cDNA, mRNA sequence
    • 9143: AB032593
      Homo sapiens mRNA for PXR2b, complete cds
      gi|7328930|dbj|AB3032593.1|AB032593[7328930]
    • 9144: AB032592
      Homo sapiens mRNA for PXR2a, complete cds
      gi|7328928|dbj|AB032592.1|AB032592[7328928]
    • 9145: AF110640
      Homo sapiens orphan seven-transmembrane receptor (VSHK1) mRNA, complete cds
      gi|7328551|gb|AF110640.1|AF110640[7328551]
    • 9147: AF181286
      Homo sapiens mutant dystrophin mRNA, partial cds
      gi|7321332|gb|AF181286.1|AF181286[7321332]
    • 9148: AF181285
      Homo sapiens X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2)
      mRNA, partial cds
      gi|7321330|gb|AF181285.1|AF181285[7321330]
    • 9149: AF181284
      Homo sapiens X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)
      mRNA, complete cds
      gi|7321328|gb|AF181284.1|AF181284[7321328]
    • 9150: G64286
      34 Human Homo sapiens STS cDNA, sequence tagged site
      gi|7274484|gb|G64286.1G64286[7274484]
    • 9151: AF145712
      Homo sapiens soluble neuropilin-1 mRNA, complete cds
      gi|7271464|gb|AF145712.1|AF145712[7271464]
    • 9180: AB031325
      Homo sapiens gene for calcium-sensing receptor, exons, promoter region
      gi|7023984|dbj|AB031325.1|AB031325[7023984]
    • 9183: AF112461
      Homo sapiens G protein-coupled receptor 57 (GPR57) gene, complete cds
      gi|6739495|gb|AF112461.1|AF112461[6739495]
    • 9184: AF112460
      Homo sapiens G protein-coupled receptor 58 (GPR58) gene, complete cds
      gi|6739493|gb|AF112460.1|AF112460[6739493]
    • 9185: AF184174
      Homo sapiens somatostatin receptor 2 (SSTR2) gene, complete cds, alternatively
      spliced
      gi|7229402|gb|AF184174.1|AF184174[7229402]
    • 9227: AF175207
      Homo sapiens lectin-like receptor F1, splice variant 1 KLRF1-s1 (KLRF1) mRNA, complete cds
      gi|7188568|gb|AF175207.1|AF175207[7188568]
    • 9228: AF175206
      Homo sapiens lectin-like receptor F1 (KLRF1) mRNA, complete cds
      gi|7188566|gb|AF175206.1|AF175206[7188566]
    • 9229: AJ271348
      Homo sapiens partial DRD3 gene for dopamine D3 receptor, exon 1
      gi|7159738|emb|AJ271348.2|HSA271348[7159738]
    • 9236: AF180814
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, exon 10 and complete cds
      gi|7157949|gb|AF180814.1|HSPEX7NB9[7157949]
    • 9237: AF180813
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, exon 9
      gi|7157948|gb|AF180813.1|HSPEX7NB8[7157948]
    • 9238: AF180812
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, exon 8
      gi|7157947|gb|AF180812.1|HSPEX7NB7[7157947]
    • 9239: AF180811
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, exon 7
      gi|7157946|gb|AF180811.1|HSPEX7NB6[7157946]
    • 9240: AF180810
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, exon 6
      gi|7157945|gb|AF180810.1|HSPEX7NB5[7157945]
    • 9241: AF180809
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, exons 4 and 5
      gi|7157944|gb|AF180809.1|HSPEX7NB4[7157944]
    • 9242: AF180808
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, exon 3
      gi|7157943|gb|AF180808.1|HSPEX7NB3[7157943]
    • 9243: AF180807
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, exon 2
      gi|7157942|gb|AF180807.1|HSPEX7NB2[7157942]
    • 9244: AF180806
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, 5′ region and exon 1
      gi|715794|gb|AF180806.1|HSPEX7NB1[7157941]
    • 9245: AH009157
      Homo sapiens peroxisomal PTS2 receptor (PEX7) gene, complete cds
      gi|7157940|gb|AH009157.1|SEG_HSPEX7NB[7157940]
    • 9246: AF087930
      Homo sapiens olfactory receptor 17-228 (OR3A2) gene, complete cds
      gi|714464|gb|AF087930.1|AF087930[7144641]
    • 9248: AF087928
      Homo sapiens olfactory receptor 17-209 (OR1G1) gene, complete cds
      gi|7144638|gb|AF087928.1|AF087928[7144638]
    • 9250: AF087926
      Homo sapiens olfactory receptor 17-201 (OR3A3) gene, complete cds
      gi|7144635|gb|AF087926.1|AF087926[7144635]
    • 9251: AF087925
      Homo sapiens olfactory receptor 17-93 (OR1E2) gene, complete cds
      gi|7144633|gb|AF087925.1|AF087925[7144633]
    • 9252: AF087924
      Homo sapiens olfactory receptor 17-40 (OR3A1) gene, complete cds
      gi|7144631|gb|AF087924.1|AF087924[7144631]
    • 9253: AF087923
      Homo sapiens olfactory receptor 17-31 (OR1D5) gene, complete cds
      gi|7144629|gb|AF087923.1|AF087923[7144629]
    • 9254: AF087922
      Homo sapiens olfactory receptor 17-30 (OR1D4) gene, complete cds
      gi|7144627|gb|AF087922.1|AF087922[7144627]
    • 9258: AF087918
      Homo sapiens olfactory receptor 17-7 (OR1A1) gene, complete cds
      gi|7144622|gb|AF087918.1|AF087918[7144622]
    • 9259: AF087917
      Homo sapiens olfactory receptor 17-4 (OR1D2) gene, complete cds
      gi|7144620|gb|AF087917.1|AF087917[7144620]
    • 9260: AF087916
      Homo sapiens olfactory receptor 17-2 (OR1E1) gene, complete cds
      gi|7144618|gb|AF087916.1|AF087916[7144618]
    • 9262: AC010582
      Homo sapiens chromosome 14 clone CTD-2547F10, complete sequence
      gi|6721135|gb|AC010582.6|AC010582[6721135]
    • 9263: AC010072
      Homo sapiens chromosome 14q31 clone CTD-217314 containing TSHR gene, partial cds; and unknown gene, complete sequence
      gi|6453843|gb|AC010072.5|AC010072[6453843]
    • 9264: AF155225
      Homo sapiens olfactory receptor 17-6 (OR1A2) gene, complete cds
      gi|5081803|gb|AF155225.1|AF155225[5081803]
    • 9265: AC007262
      Homo sapiens chromosome 14 clone containing gene for thyroid stimulating hormone
      receptor, partial CDS, complete sequence
      gi|4883585|gb|AC007262.4|AC007262[4883585]
    • 9266: AC002085
      Homo sapiens Chromosome 17 p13 Cosmid Clone cos26, complete sequence
      gi|4835805|gb|AC002085.2|AC002085[4835805]
    • 9267: AC006531
      Homo sapiens chromosome 16 clone 113K5, complete sequence
      gi|4235137|gb|AC006531.1|AC006531[4235137]
    • 9268: AC004164
      Homo sapiens chromosome 19, cosmid R26450, complete sequence
      gi|2905827|gb|AC004164.1|AC004164[2905827]
    • 9269: AF200949
      Homo sapiens C-type lectin-like receptor-1 mRNA, complete cds
      gi|7110215|gb|AF200949.1|AF200949[7110215]
    • 9277: AF124841
      Homo sapiens C-type lectin-like receptor-2 mRNA, complete cds
      gi|7109730|gb|AF124841.1|AF124841[7109730]
    • 9278: AF210818
      Homo sapiens SWAP-70 mRNA, complete cds
      gi|6691098|gb|AF210818.1|AF210818[6691098]
    • 9281: AF134838
      Homo sapiens endocytic receptor Endo180 (ENDO180) mRNA, complete cds
      gi|4835877|gb|AF134838.1|AF134838[4835877]
    • 9282: U89326
      Homo sapiens bone morphogenetic protein receptor type I ALK-6 mRNA, complete cds
      gi|3377788|gb|U89326.1|HSU89326[3377788]
    • 9283: AJ003080
      Homo sapiens mRNA for serotonin receptor (short isoform)
      gi|3115225|emb|AJ003080.1|HSAJ3080[3115225]
    • 9284: AJ003079
      Homo sapiens mRNA for 5-hydroxytryptamine3 receptor
      gi|3115223|emb|AJ003079.1|HSAJ3079[3115223]
    • 9285: AJ003078
      Homo sapiens mRNA for 5-HT3 serotonin receptor (long isoform)
      gi|3115221|emb|AJ003078.1|HSAJ3078[3115221]
    • 9286: AC024126
      Homo sapiens chromosome 11 clone cosmid f-o-8180 map 11q13, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces
      gi|7025812|gb|AC024126.1|AC024126[7025812]
    • 9287: AC024124
      Homo sapiens chromosome 11 clone cosmid b-o-7185 map 11q13, *** SEQUENCING IN PROGRESS ***, 4 ordered pieces
      gi|7025810|gb|AC024124.1|AC024124[7025810]
    • 9288: AC024123
      Homo sapiens chromosome 11 clone bac67-m-5 map 11q13, *** SEQUENCING IN PROGRESS ***, 3 ordered pieces
      gi|7025809|gb|AC024123.1|AC024123[7025809]
    • 9289: AF226728
      Homo sapiens somatostatin receptor-interacting protein splice variant b (SSTRIP)
      mRNA, complete cds
      gi|7025450|gb|AF226728.1|AF226728[7025450]
    • 9290: AL157442
      Homo sapiens mRNA; cDNA DKFZp586P1424 (from clone DKFZp586P1424); partial cds
      gi|7018558|emb|AL157442.1|HSM802508[7018558]
    • 9291: AF217796
      Homo sapiens SCG10 like-protein, helicase-like protein NHL, M68, and ADP-ribosylation factor related protein 1 (ARFRP1) genes, complete cds
      gi|7012928|gb|AF217796.1|AF217796[7012928]
    • 9293: AL137719
      Homo sapiens mRNA; cDNA DKFZp434K1831 (from clone DKFZp434K1831); partial cds
      gi|6808155|emb|AL137719.1|HSM802224[6808155]
    • 9294: AL137432
      Homo sapiens mRNA; cDNA DKFZp761E1824 (from clone DKFZp761E1824); partial cds
      gi|6807990|emb|AL137432.1|HSM802135[6807990]
    • 9295: AL137375
      Homo sapiens mRNA; cDNA DKFZp43411926 (from clone DKFZp43411926); partial cds
      gi|6807903|emb|AL137375.1|HSM802063[6807903]
    • 9296: AL137288
      Homo sapiens mRNA; cDNA DKFZp434F1516 (from clone DKFZp434F1S16); partial cds
      gi|6807745|emb|AL137288.1|HSM801953[6807745]
    • 9297: AL137651
      Homo sapiens mRNA; cDNA DKFZp43400213 (from clone DKFZp43400213); partial cds
      gi|6807717|emb|AL137651.1|HSM801924[6807717]
    • 9298: AL133666
      Homo sapiens mRNA; cDNA DKFZp434C1418 (from clone DKFZp434C1418); partial cds
      gi|6599298|emb|AL133666.1|HSM801500[6599298]
    • 9299: AL133097
      Homo sapiens mRNA; cDNA DKFZp434N1928 (from clone DKFZp434N1928)
      gi|6453551|emb|AL133097.1|HSM801374[6453551]
    • 9300: AL133058
      Homo sapiens mRNA; cDNA DKFZp434K0615 (from clone DKFZp434K0615); partial cds
      gi|6453479|emb|AL133058.1|HSM801329[6453479]
    • 9301: AL133030
      Homo sapiens mRNA; cDNA DKFZp434H177 (from clone DKFZp434H177); partial cds
      gi|6453431|emb|AL133030.1|HSM801297[6453431]
    • 9304: AL117432
      Homo sapiens mRNA; cDNA DKFZp434E066 (from clone DKFZp434E066); partial cds
      gi|5911868|emb|AL117432.1|HSM800941[5911868]
    • 9305: AL096753
      Homo sapiens mRNA; cDNA DKFZp434C192 (from clone DKFZp434C192); partial cds
      gi|5419889|emb|AL096753.1|HSM800719[5419889]
    • 9306: AL080164
      Homo sapiens mRNA; cDNA DKFZp564C1940 (from clone DKFZp564C1940); partial cds
      gi|5262628|emb|AL080164.1|HSM800683[5262628]
    • 9307: AL050071
      Homo sapiens mRNA; cDNA DKFZp566B0846 (from clone DKFZp566B0846); partial cds
      gi|4884302|emb|AL050071.1|HSM800396[4884302]
    • 9308: AL049924
      Homo sapiens mRNA; cDNA DKFZp564G1182 (from clone DKFZp564G1182); partial cds
      gi|4884170|emb|AL049924.1|HSM800265[4884170]
    • 9309: X68559
      Homo sapiens partial FGFR-4 gene for acidic fibroblast growth factor
      gi|556841|emb|X68559.1|HSFGRF[556841]
    • 9310: AF228312
      Homo sapiens T-cell receptor zeta chain precursor, mRNA, partial cds
      gi|6984206|gb|AF228312.1|AF228312[6984206]
    • 9311: AF199028
      Homo sapiens B7-like protein (GL50) mRNA, complete cds
      gi|6983943|gb|AF199028.1|AF199028[6983943]
    • 9315: AF225903
      Homo sapiens D1 dopamine receptor interacting protein calcyon mRNA, complete cds
      gi|6980075|gb|AF225903.1|AF225903[6980075]
    • 9316: AF222340
      Homo sapiens type 1 tumor necrosis factor receptor shedding aminopeptidase regulator mRNA, complete cds
      gi|6979942|gb|AF222340.1|AF222340[6979942]
    • 9317: AF201349
      Homo sapiens glutamate receptor C gene, partial cds
      gi|6690029|gb|AF201349.1|AF201349[6690029]
    • 9318: AF201343
      Homo sapiens glutamate receptor B flop isoform and glutamate receptor B flip isoform genes, partial cds
      gi|6690023|gb|AF201343.1|AF201343[6690023]
    • 9319: AJ271729
      Homo sapiens mRNA for glucose-regulated protein (HSPA5 gene)
      gi|6900103|emb|AJ271729.1|HSA271729[6900103]
    • 9320: AF217794
      Homo sapiens M68E mRNA, alternatively spliced, complete cds
      gi|6969262|gb|AF217794.1|AF217794[6969262]
    • 9321: AF217793
      Homo sapiens M68C mRNA, alternatively spliced, complete cds
      gi|6969260|gb|AF217793.1|AF217793[6969260]
    • 9322: AF152238
      Homo sapiens V1b vasopressin receptor (VPR3) gene, complete cds
      gi|6969252|gb|AF152238.1|AF152238[6969252]
    • 9325: X89271
      H. sapiens mRNA for HG11 orphan receptor
      gi|6911643|emb|X89271.1|HSHG11ORP[6911643]
    • 9328: AJ240085
      Homo sapiens mRNA for T-cell receptor interacting molecule protein, splice variant (TRIM gene)
      gi|6911580|emb|AJ240085.1|HSA240085[6911580]
    • 9330: AJ271684
      Homo sapiens mRNA for myeloid DAP12-associating lectin (MDL-1 gene)
      gi|6900101|emb|AJ271684.1|HSA271684[6900101]
    • 9331: AJ243213
      Homo sapiens partial 5-HT4 receptor gene, exons 2 to 5
      gi|6900061|emb|AJ243213.1|HSA243213[6900061]
    • 9332: AC003075
      Human PAC clone RP4-658N5 from 7p21, complete sequence
      gi|2588637|gb|AC003075.1|AC003075[2588637]
    • 9333: AC003078
      Human BAC clone GS1-117010 from 7q21-q22, complete sequence
      gi|258863|gb|AC003078.1|AC003078[2588631]
    • 9334: AC002381
      Human BAC clone CTB-20D2 from 7q22, complete sequence
      gi|2275186|gb|AC002381.1|AC002381[2275186]
    • 9335: AC005155
      Homo sapiens PAC clone RP5-877J2 from 7 p14-p15, complete sequence
      gi|3242760|gb|AC005155.1|AC005155[3242760]
    • 9338: D50678
      Human mRNA for apolipoprotein E receptor 2, complete cds
      gi|1321643|dbj|D50678.1|D50678[1321643]
    • 9339: D31770
      Human osteosarcoma mRNA for activin typeII A receptor, complete cds
      gi|1321631|dbj|D31770.1|HUMACTRIIA[1321631]
    • 9340: D50516
      Human mRNA for type II receptor for bone morphogenetic protein-4, complete cds
      gi|807712|dbj|D50516.1|HUMBMP4A[807712]
    • 9341: D31661
      Human mRNA for tyrosine kinase, complete cds
      gi|495677|dbj|D31661.1|HUMERKA[495677]
    • 9342: D17516
      Homo sapiens mRNA for PACAP receptor, complete cds
      gi|457562|dbj|D17516.1|HUMPACAPR[457562]
    • 9343: D16105
      Human mRNA for leukocyte tyrosine kinase, complete cds
      gi|440854|dbj|D516105.1|HUMLTKLP2[440854]
    • 9344: D16494
      Human mRNA for very low density lipoprotein receptor, complete cds
      gi|391735|dbj|D516494.1|HUMVLDLRB[391735]
    • 9345: D16493
      Human mRNA for very low density lipoprotein receptor, complete cds
      gi|391733|dbj|D516493.1|HUMVLDLRA[391733]
    • 9346: G63891
      GRM7 Human Homo sapiens STS genomic 3′, sequence tagged site
      gi|6842052|gb|G63891.1|G63891[6842052]
    • 9347: G63890
      GRM4 Human Homo sapiens STS genomic 5′, sequence tagged site
      gi|6842051|gb|G63890.1|G63890[6842051]
    • 9471: AF148806
      Homo sapiens dopamine receptor D2 (DRD2) gene, 5′-flanking region and exon 1
      gi|6759904|gb|AF148806.1|AF148806[6759904]
    • 9473: AF189251
      Homo sapiens cytomegalovirus partial fusion receptor mRNA, partial cds
      gi|6760349|gb|AF189251.1|AF189251[6760349]
    • 9474: AF202063
      Homo sapiens fibroblast growth factor receptor 4, soluble-form splice variant (FGFR4) mRNA, complete cds
      gi|6739817|gb|AF202063.1|AF202063[6739817]
    • 9475: AF201951
      Homo sapiens high affinity immunoglobulin epsilon receptor beta subunit mRNA, complete cds
      gi|6563299|gb|AF201951.1|AF201951[6563299]
    • 9476: AB037108
      Homo sapiens mRNA for seven transmembrane domain orphan receptor, complete cds
      gi|6729335|dbj|AB037108.1|AB037108[6729335]
    • 9478: AF209721
      Homo sapiens IgG Fc receptor locus, partial sequence
      gi|6715394|gb|AF209721.1|AF209721[6715394]
    • 9480: AJ238323
      Homo sapiens mRNA for NK inhibitory receptor (IRC2)
      gi|6707798|emb|AJ238323.1|HSA238323[6707798]
    • 9481: AB036432
      Homo sapiens RAGE mRNA for advanced glycation endproducts receptor, complete cds
      gi|6691625|dbj|AB036432.1|AB036432[6691625]
    • 9482: AF192548
      Homo sapiens tumor necrosis factor receptor-like protein ZTNFR9 (ZTNFR9) mRNA,
      complete cds
      gi|6319129|gb|AF192548.1|AF192548[6319129]
    • 9483: AF184971
      Homo sapiens class II cytokine receptor ZCYTOR7 (ZCYTOR7) mRNA, complete cds
      gi|6013324|gb|AF184971.1|AF184971[6013324]
    • 9484: AJ012288
      Homo sapiens mRNA for GABA-BR1
      gi|4186035|emb|AJ012288.1|HSA012288[4186035]
    • 9485: AB035073
      Homo sapiens mRNA for platelet glycoprotein VI, complete cds
      gi|6691622|dbj|AB035073.1|AB035073[6691622]
    • 9486: AF217403
      Homo sapiens low density lipoprotein receptor (LDLR) gene, partial cds
      gi|6691160|gb|AF217403.1|AF217403[6691160]
    • 9487: AF200465
      Homo sapiens coxsackievirus and adenovirus receptor (CXADR) gene, complete cds;
      and ANA gene, partial cds
      gi|6690789|gb|AF200465.1|AF200465[6690789]
    • 9509: AJ243342
      Homo sapiens mRNA for nicotinic acetylcholine receptor alpha 9 subunit (NACHRA9 gene)
      gi|6688135|emb|AJ243342.1|HSA243342[6688135]
    • 9510: AJ223183
      Homo sapiens mRNA for DORA protein
      gi|3925598|emb|AJ223183.1|HSAJ3183[3925598]
    • 9512: AF006265
      Homo sapiens cancer associated surface antigen (RCAS1) mRNA, complete cds
      gi|2213933|gb|AF006265.1|AF006265[2213933]
    • 9513: AF159570
      Homo sapiens regulator of G-protein signalling 5 (RGS5) mRNA, complete cds
      gi|5230675|gb|AF159570.1|AF159570[5230675]
    • 9515: D29952
      Human DNA for alpha1A/D adrenergic receptor, complete cds
      gi|914933|dbj|D29952.1|HUMA1ADAR[914933]
    • 9516: NM004441
      Homo sapiens EphB1 (EPHB1) mRNA
      gi|4758283|ref|NM004441.1|[4758283]
    • 9532: AF133299
      Homo sapiens lectin-like NK cell receptor LLT1 (LLT1) mRNA, complete cds
      gi|6651064|gb|AF133299.1|AF133299[6651064]
    • 9533: AF110265
      Homo sapiens epidermal growth factor receptor substrate EPS15R mRNA, complete cds
      gi|6650598|gb|AF110265.1|AF110265[6650598]
    • 9535: AF061779
      Homo sapiens cosmid 25, complete sequence
      gi|6650204|gb|AF061779.1|AF061779[6650204]
    • 9537: AF118224
      Homo sapiens matriptase mRNA, complete cds
      gi|6647301|gb|AF118224.2|AF118224[6647301]
    • 9538: AF125809
      Homo sapiens neurotrophic receptor tyrosine kinase-ETS related protein fusion protein (NTRK3-ETV6 fusion) mRNA, partial cds
      gi|6635288|gb|AF125809.1|AF125809[6635288]
    • 9539: AF125808
      Homo sapiens ETS related protein-neurotrophic receptor tyrosine kinase fusion protein (ETV6-NTRK3 fusion) mRNA, partial cds
      gi|6635286|gb|AF125808.1|AF125808[6635286]
    • 9540: AJ000542
      Homo sapiens partial p58 gene for NK receptor
      gi|6624934|emb|AJ000542.2|HSP58NKRC[6624934]
    • 9541: AF190826
      Homo sapiens P2X2A receptor (P2X2) gene, complete cds
      gi|6606329|gb|AF190826.1|AF190826[6606329]
    • 9542: AF190825
      Homo sapiens P2X2D receptor (P2X2) mRNA, complete cds
      gi|6606327|gb|AF190825.1|AF190825[6606327]
    • 9543: AF190824
      Homo sapiens P2X2C receptor (P2X2) mRNA, complete cds
      gi|6606325|gb|AF190824.1|AF190824[6606325]
    • 9544: AF190823
      Homo sapiens P2X2B receptor (P2X2) mRNA, complete cds
      gi|6606323|gb|AF190823.1|AF190823[6606323]
    • 9545: AF190822
      Homo sapiens P2X2A receptor (P2X2) mRNA, complete cds
      gi|660632|gb|AF190822.1|AF190822[6606321]
    • 9546: AH008809
      Homo sapiens FGF receptor activating protein 1 (FRAG1) gene, complete cds
      gi|6606289|gb|AH008809.1|SEG_AF159616S[6606289]
    • 9547: AF159621
      Homo sapiens FGF receptor activating protein 1 (FRAG1) gene, exon 6 and complete
      cds
      gi|6606288|gb|AF159621.1|AF159616S6[6606288]
    • 9548: AF159620
      Homo sapiens FGF receptor activating protein 1 (FRAG1) gene, exon 5
      gi|6606287|gb|AF159620.1|AF159616S5[6606287]
    • 9549: AF159619
      Homo sapiens FGF receptor activating protein 1 (FRAG1) gene, exon 4
      gi|6606286|gb|AF159619.1|AF159616S4[6606286]
    • 9550: AF159618
      Homo sapiens FGF receptor activating protein 1 (FRAG1) gene, exon 3
      gi|6606285|gb|AF159618.1|AF159616S3[6606285]
    • 9551: AF159617
      Homo sapiens FGF receptor activating protein 1 (FRAG1) gene, exon 2
      gi|6606284|gb|AF159617.1|AF159616S2[6606284]
    • 9552: AF159616
      Homo sapiens FGF receptor activating protein 1 (FRAG1) gene, exon 1
      gi|6606283|gb|AF159616.1|AF159616S1[6606283]
    • 9553: AH008808
      Homo sapiens PPAR gamma coactivator (PPAR gamma coactivator) gene, complete cds
      gi|6606153|gb|AH008808.1|SEG_F108193S[6606153]
    • 9554: AF108205
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 13 and complete cds
      gi|6606152|gb|AF108205.1|F108193S13[6606152]
    • 9555: AF108204
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 12
      gi|6606151|gb|AF108204.1|F108193S12[6606151]
    • 9556: AF108203
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 11
      gi|6606150|gb|AF108203.1|F108193S11[6606150]
    • 9557: AF108202
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 10
      gi|6606149|gb|AF108202.1|F108193S10[6606149]
    • 9558: AF108201
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 9
      gi|6606148|gb|AF108201.1|F108193S09[6606148]
    • 9559: AF108200
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 8
      gi|6606147|gb|AF108200.1|F108193S08[6606147]
    • 9560: AF108199
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 7
      gi|6606146|gb|AF108199.1|F108193S07[6606146]
    • 9561: AF108198
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 6
      gi|6606145|gb|AF108198.1|F108193S06[6606145]
    • 9562: AF108197
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 5
      gi|6606144|gb|AF108197.1|F108193S05[6606144]
    • 9563: AF108196
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 4
      gi|6606143|gb|AF108196.1F108193S04[6606143]
    • 9564: AF108195
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 3
      gi|6606142|gb|AF108195.1|F108193S03[6606142]
    • 9565: AF108194
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 2
      gi|6606141|gb|AF108194.1|F108193S02[6606141]
    • 9566: AF108193
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) gene, exon 1
      gi|6606140|gb|AF108193.1|F108193S01[6606140]
    • 9567: AC005009
      Homo sapiens BAC clone GS1-67A24 from 7q21.q21.2, complete sequence
      gi|4156150|gb|AC005009.1|AC005009[4156150]
    • 9568: AF047487
      Homo sapiens Nck-2 (NCK2) mRNA, complete cds
      gi|3930216|gb|AF047487.1|AF047487[3930216]
    • 9569: AC004822
      Homo sapiens PAC clone RP1-170D19 from Xq23, complete sequence
      gi|3845420|gb|AC004822.1|AC004822[3845420]
    • 9570: AC002543
      Homo sapiens BAC clone CTA-300C3 from 7q31.2, complete sequence
      gi|3645947|gb|AC002543.1|AC002543[3645947]
    • 9571: AC002081
      Homo sapiens BAC clone CTA-331C24 from 7q21, complete sequence
      gi|2078453|gb|AC002081.1|AC002081[2078453]
    • 9572: AF106698
      Homo sapiens PPAR gamma coactivator-1 (PPARGC1) mRNA, complete cds
      gi|6594644|gb|AF106698.1|AF106698[6594644]
    • 9574: AH002552
      Homo sapiens CHRNG gene, complete sequence; and acetylcholine receptor gamma-subunit (ACHR) gene, partial cds
      gi|6579185|gb|AH002552.2|SEG_HUMACHRG[6579185]
    • 9575: L29197
      Homo sapiens acetylcholine receptor gamma-subunit (ACHR) gene, exons 10 and 11
      gi|457433|gb|L29197.1|HUMACHRG7[457433]
    • 9576: M11811
      Homo sapiens acetylcholine receptor gamma-subunit (ACHR) gene, exon 12 and partial cds
      gi|177984|gb|M11811.1|HUMACHRG8[177984]
    • 9580: AF119666
      Homo sapiens insulin receptor tyrosine kinase substrate mRNA, complete cds
      gi|6563257|gb|AF119666.1|AF119666[6563257]
    • 9581: AF109683
      Homo sapiens leukocyte-associated Ig-like receptor 1b mRNA, complete cds
      gi|6563041|gb|AF109683.1|AF109683[6563041]
    • 9582: AH008758
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, complete cds
      gi|6561205|gb|AH008758.1|SEG_HSILGFR[6561205]
    • 9583: AF109291
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 48 and complete cds
      gi|6561204|gb|AF109291.1|HSILGFR48[6561204]
    • 9584: AF109290
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 47
      gi|6561203|gb|AF109290.1|HSILGFR47[6561203]
    • 9585: AF109289
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 46
      gi|6561202|gb|AF109289.1|HSILGFR46[6561202]
    • 9586: AF109288
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 45
      gi|656120|gb|AF109288.1|HSILGFR45[6561201]
    • 9587: AF109287
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 44
      gi|6561200|gb|AF109287.1|HSILGFR44[6561200]
    • 9588: AF109286
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 43
      gi|6561199|gb|AF109286.1|HSILGFR43[6561199]
    • 9589: AF109285
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 42
      gi|6561198|gb|AF109285.1|HSILGFR42[6561198]
    • 9590: AF109284
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 41
      gi|6561197|gb|AF109284.1|HSILGFR41[6561197]
    • 9591: AF109283
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 40
      gi|6561196|gb|AF109283.1|HSILGFR40[6561196]
    • 9592: AF109282
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 39
      gi|6561195|gb|AF109282.1|HSILGFR39[6561195]
    • 9593: AF109281
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 38
      gi|6561194|gb|AF109281.1|HSILGFR38[6561194]
    • 9594: AF109280
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 37
      gi|6561193|gb|AF109280.1|HSILGFR37[6561193]
    • 9595: AF109279
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 36
      gi|6561192|gb|AF109279.1|HSILGFR36[6561192]
    • 9596: AF109278
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 35
      gi|6561191|gb|AF109278.1|HSILGFR35[6561191]
    • 9597: AF109277
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 34
      gi|6561190|gb|AF109277.1|HSILGFR34[6561190]
    • 9598: AF109276
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 33
      gi|6561189|gb|AF109276.1|HSILGFR33[6561189]
    • 9599: AF109275
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 32
      gi|6561188|gb|AF109275.1|HSILGFR32[6561188]
    • 9600: AF109274
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 31
      gi|6561187|gb|AF109274.1|HSILGFR31[6561187]
    • 9601: AF109273
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 30
      gi|6561186|gb|AF109273.1|HSILGFR30[6561186]
    • 9602: AF109272
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 29
      gi|6561185|gb|AF109272.1|HSILGFR29[6561185]
    • 9603: AF109271
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 28
      gi|6561184|gb|AF109271.1|HSILGFR28[6561184]
    • 9604: AF109270
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 27
      gi|6561183|gb|AF109270.1|HSILGFR27[6561183]
    • 9605: AF109269
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 26
      gi|6561182|gb|AF109269.1|HSILGFR26[6561182]
    • 9606: AF109268
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 25
      gi|6561181|gb|AF109268.1|HSILGFR25[6561181]
    • 9607: AF109267
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 24
      gi|6561180gb|AF109267.1|HSILGFR24[6561180]
    • 9608: AF109266
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 23
      gi|6561179|gb|AF109266.1|HSILGFR23[6561179]
    • 9609: AF109265
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 22
      gi|6561178|gb|AF109265.1|HSILGFR22[6561178]
    • 9610: AF109264
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 21
      gi|6561177|gb|AF109264.1|HSILGFR21[6561177]
    • 9611: AF109263
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 20
      gi|6561176|gb|AF109263.1|HSILGFR20[6561176]
    • 9612: AF109262
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 19
      gi|6561175|gb|AF109262.1|HSILGFR19[6561175]
    • 9613: AF109261
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 18
      gi|6561174|gb|AF109261.1|HSILGFR18[6561174]
    • 9614: AF109260
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 17
      gi|6561173|gb|AF109260.1|HSILGFR17[6561173]
    • 9615: AF109259
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 16
      gi|6561172|gb|AF109259.1|HSILGFR16[6561172]
    • 9616: AF109258
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 15
      gi|6561171|gb|AF109258.1|HSILGFR15[6561171]
    • 9617: AF109257
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 14
      gi|6561170gb|AF109257.1|HSILGFR14[6561170]
    • 9618: AF109256
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 13
      gi|6561169|gb|AF109256.1|HSILGFR13[6561169]
    • 9619: AF109255
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 12
      gi|6561168|gb|AF109255.1|HSILGFR1 2[6561168]
    • 9620: AF109254
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 11
      gi|6561167|gb|AF109254.1|HSILGFR11[6561167]
    • 9621: AF109253
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 10
      gi|6561166|gb|AF109253.1|HSILGFR10[6561166]
    • 9622: AF109252
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 9
      gi|6561165|gb|AF109252.1|HSILGFR09[6561165]
    • 9623: AF109251
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 8
      gi|6561164|gb|AF109251.1|HSILGFR08[6561164]
    • 9624: AF109250
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 7
      gi|6561163|gb|AF109250.1|HSILGFR07[6561163]
    • 9625: AF109249
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 6
      gi|6561162|gb|AF109249.1|HSILGFR06[6561162]
    • 9626: AF109248
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 5
      gi|6561161|gb|AF109248.1HSILGFR05[6561161]
    • 9627: AF109247
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 4
      gi|6561160gb|AF109247.1|HSILGFR04[6561160]
    • 9628: AF109246
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 3
      gi|6561159|gb|AF109246.1|HSILGFR03[6561159]
    • 9629: AF109245
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 2
      gi|6561158|gb|AF109245.1|HSILGFR02[6561158]
    • 9630: AF109244
      Homo sapiens insulin-like growth factor 2 receptor (IGF2R) gene, exon 1
      gi|6561157|gb|AF109244.1|HSILGFR01[6561157]
    • 9631: AF178684
      Homo sapiens class I cytokine receptor (zcytor5) mRNA, complete cds
      gi|5853247|gb|AF178684.1|AF178684[5853247]
    • 9632: AQ917583
      hxa18 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552294|gb|AQ917583.1|AQ917583[6552294]
    • 9633: AQ917582
      hxa17 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552293|gb|AQ917582.1|AQ917582[6552293]
    • 9634: AQ917581
      hxa16 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552292|gb|AQ917581.1|AQ917581[6552292]
    • 9635: AQ917580
      hxa15 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552291|gb|AQ917580.1|AQ917580[6552291]
    • 9636: AQ917579
      hxa14 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552290|gb|AQ917579.1|AQ917579[6552290]
    • 9637: AQ917578
      hxa13 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552289|gb|AQ917578.1|AQ917578[6552289]
    • 9638: AQ917577
      hxa12 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552288|gb|AQ917577.1|AQ917577[6552288]
    • 9639: AQ917576
      Hxa11 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552287|gb|AQ917576.1|AQ917576[6552287]
    • 9640: AQ917575
      hxa10 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552286|gb|AQ917575.1|AQ917575[6552286]
    • 9641: AQ917574
      hxa9 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552285|gb|AQ917574.1|AQ917574[6552285]
    • 9642: AQ917573
      hxa8 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552284|gb|AQ917573.1|AQ917573[6552284]
    • 9643: AQ917572
      hxa7 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552283|gb|AQ917572.1|AQ917572[6552283]
    • 9644: AQ917571
      hxa6 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552282|gb|AQ917571.1|AQ917571[6552282]
    • 9645: AQ917570
      hxa5 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552281|gb|AQ917570.1|AQ917570[6552281]
    • 9646: AQ917569
      hxa4 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552280|gb|AQ917569.1|AQ917569[6552280]
    • 9647: AQ917568
      hxa3 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552279|gb|AQ917568.1|AQ917568[6552279]
    • 9648: AQ917567
      hxa2 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552278|gb|AQ917567.1|AQ917567[6552278]
    • 9649: AQ917566
      hxa1 Bac Human I Homo sapiens genomic, genomic survey sequence
      gi|6552277|gb|AQ917566.1|AQ917566[6552277]
    • 9650: AH008470
      Homo sapiens somatostatin receptor subtype 2 gene, partial cds
      gi|6531649|gb|AH008470.1|SEG_AF182397S[6531649]
    • 9652: AF182397
      Homo sapiens somatostatin receptor subtype 2 gene, promoter region and patial
      cds
      gi|6531647|gb|AF182397.1|AF182397S1[6531647]
    • 9654: AF068757
      Homo sapiens somatostatin receptor subtype 3 (SSTR3) gene, 5′ flanking region and partial cds
      gi|6523784|gb|AF068757.1|AF068757[6523784]
    • 9656: AF166329
      Homo sapiens intermediate prolactin receptor isoform mRNA, complete cds
      gi|5734139|gb|AF166329.1|AF166329[5734139]
    • 9658: AJ251595
      Homo sapiens mRNA for transmembrane glycoprotein (CD44 gene)
      gi|6491738|emb|AJ251595.1|HSA251595[6491738]
    • 9659: AF100772
      Homo sapiens tenascin-M1 (TNM1) mRNA, complete cds
      gi|6165844|gb|AF100772.1|AF100772[6165844]
    • 9660: AF100634
      Homo sapiens Duffy antigen/Receptor for chemokines (DARC) gene, DARC-Fya allele,
      partial cds
      gi|6048958|gb|AF100634.1|AF100634[6048958]
    • 9661: AH008438
      Homo sapiens outer membrane receptor Tom20 (TOM20) gene, complete cds
      gi|6469611|gb|AH008438.1|SEG_HS20TOM[6469611]
    • 9662: AF019638
      Homo sapiens nedasin s-form mRNA, complete cds
      gi|6469319|gb|AF019638.1|AF019638[6469319]
    • 9663: AB3010445
      Homo sapiens mRNA for CC chemokine ILC, complete cds
      gi|6469037|dbj|AB010445.1|AB010445[6469037]
    • 9664: AF119330
      Synthetic construct from Homo sapiens dopamine receptor D4-7 mRNA, partial cds
      gi|4325159|gb|AF119330.1|AF119330[4325159]
    • 9665: AF119329
      Synthetic construct from Homo sapiens dopamine receptor D4-4 mRNA, partial cds
      gi|4325157|gb|AF119329.1|AF119329[4325157]
    • 9666: AF119328
      Synthetic construct from Homo sapiens dopamine receptor D4-2 mRNA, partial cds
      gi|4325155|gb|AF119328.1|AF119328[4325155]
    • 9667: AL021940
      Homo sapiens DNA sequence from PAC 117P20 on chromosome 1q24. Contains the LNHR
      (SELL) gene coding for Lymph Node Homing Receptor (L-Selectin precursor, LAM-1
      Leukocyte Adhesion Molecule, Leukocyte surface antigen Leu-8, TQ1, GP90-MEL, LECAM1 Leukocyte-Endothelial Cell Adhesion Molecule 1, CD62L). Contains the SELE
      gene coding for E-Selectin precursor (CD62E, ELAM-1 Endothelial Leukocyte Adhesion Molecule 1, LECAM-2 Leukocyte-Endothelial Cell Adhesion Molecule 2).
      Contains an unknown gene with homology to predicted yeast. plant and worm proteins. Contains ESTs and STSs, complete sequence
      gi|3115962|emb|AL021940.1|HS117P20[3115962]
    • 9668: AF152113
      Homo sapiens perforin gene, IL-2 responsive enhancer sequence
      gi|6467393|gb|AF152113.1|AF152113[6467393]
    • 9669: AB022178
      Homo sapiens mRNA for calcitonin receptor, complete cds, isolate from bone marrow osteoclast
      gi|6456431|dbj|AB022178.1|AB022178[6456431]
    • 9670: AB022177
      Homo sapiens mRNA for calcitonin receptor, complete cds, isolate from breast carcinoma
      gi|6456429|dbj|AB022177.1|AB022177[6456429]
    • 9671: AJ251004
      Homo sapiens ITGB4 gene for integrin beta 4, exons 1-2 and joined CDS
      gi|6453379|emb|AJ251004.1|HSA251004[6453379]
    • 9672: AJ133822
      Homo sapiens mRNA for receptor for Advanced Glycation End Product, secreted isoform (RAGEsec gene)
      gi|4877290|emb|AJ133822.1|HSA133822[4877290]
    • 9673: Y18994
      Homo sapiens GABRR3 gene, partial
      gi|6434194|emb|Y18994.1|HSP18994[6434194]
    • 9676: AF177766
      Homo sapiens human toll-like receptor 4 (TLR4) gene, TLR4B allele, partial cds
      gi|6403466|gb|AF177766.1|AF177766[6403466]
    • 9677: AH008297
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, complete
      cds
      gi|6090614|gb|AH008297.1|SEG_HSDRA2S[6090614]
    • 9678: AF083854
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 40
      and complete cds
      gi|6090613|gb|AF083854.1|HSDRA2S38[6090613]
    • 9679: AF083853
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 39
      gi|6090612|gb|AF083853.1|HSDRA2S37[6090612]
    • 9680: AF083852
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 38
      gi|6090611|gb|AF083852.1|HSDRA2S36[6090611]
    • 9681: AF083851
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 37
      gi|6090610gb|AF083851.1|HSDRA2S35[6090610]
    • 9682: AF083850
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 36
      gi|6090609|gb|AF083850.1|HSDRA2S34[6090609]
    • 9683: AF083849
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exons 34
      and 35
      gi|6090608|gb|AF083849.1|HSDRA2S33[6090608]
    • 9684: AF083848
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 33
      gi|6090607|gb|AF083848.1|HSDRA2S32[6090607]
    • 9685: AF083847
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 32
      gi|6090606|gb|AF083847.1|HSDRA2S31[6090606]
    • 9686: AF083846
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 31
      gi|6090605|gb|AF083846.1|HSDRA2S30[6090605]
    • 9687: AF083845
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 30
      gi|6090604|gb|AF083845.1|HSDRA2S29[6090604]
    • 9688: AF083844
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 29
      gi|6090603|gb|AF083844.1|HSDRA2S28[6090603]
    • 9689: AF083843
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 28
      gi|6090602|gb|AF083843.1|HSDRA2S27[6090602]
    • 9690: AF083842
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 27
      gi|6090601|gb|AF083842.1|HSDRA2S26[6090601]
    • 9691: AF083841
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 26
      gi|6090600|gb|AF083841.1|HSDRA2S25[6090600]
    • 9692: AF083840
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 25
      gi|6090599|gb|AF083840.1|HSDRA2S24[6090599]
    • 9693: AF083839
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 24
      gi|6090598|gb|AF083839.1|HSDRA2S23[6090598]
    • 9694: AF083838
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 23
      gi|6090597|gb|AF083838.1|HSDRA2S22[6090597]
    • 9695: AF083837
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 22
      gi|6090596|gb|AF083837.1|HSDRA2S21[6090596]
    • 9696: AF083836
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 21
      gi|6090595|gb|AF083836.1|HSDRA2S20[6090595]
    • 9697: AF083835
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 20
      gi|6090594|gb|AF083835.1|HSDRA2S19[6090594]
    • 9698: AF083834
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 19
      gi|6090593|gb|AF083834.1|HSDRA2S18[6090593]
    • 9699: AF083833
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exons 17
      and 18
      gi|6090592|gb|AF083833.1|HSDRA2S17[6090592]
    • 9700: AF083832
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 16
      gi|6090591|gb|AF083832.1|HSDRA2S16[6090591]
    • 9701: AF083831
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 15
      gi|6090590|gb|AF083831.1|HSDRA2S15[6090590]
    • 9702: AF083830
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 14
      gi|6090589|gb|AF083830.1|HSDRA2S14[6090589]
    • 9703: AF083829
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 13
      gi|6090588|gb|AF083829.1|HSDRA2S13[6090588]
    • 9704: AF083828
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 12
      gi|6090587|gb|AF083828.1|HSDRA2S12[6090587]
    • 9705: AF083827
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 11
      gi|6090586|gb|AF083827.1|HSDRA2S11[6090586]
    • 9706: AF083826
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 10
      gi|6090585|gb|AF083826.1|HSDRA2S10[6090585]
    • 9707: AF083825
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 9
      gi|6090584|gb|AF083825.1|HSDRA2S09[6090584]
    • 9708: AF083824
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 8
      gi|6090583|gb|AF083824.1|HSDRA2S08[6090583]
    • 9709: AF083823
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 7
      gi|6090582|gb|AF083823.1|HSDRA2S07[6090582]
    • 9710: AF083822
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 6
      gi|6090581|gb|AF083822.1|HSDRA2S06[6090581]
    • 9711: AF083821
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 5
      gi|6090580|gb|AF083821.1|HSDRA2S05[6090580]
    • 9712: AF083820
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 4
      gi|6090579|gb|AF083820.1|HSDRA2S04[6090579]
    • 9713: AF083819
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 3
      gi|60905781|gb|AF083819.1|HSDRA2S03[6090578]
    • 9714: AF083818
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 2
      gi|6090577|gb|AF083818.1|HSDRA2S02[6090577]
    • 9715: AF083817
      Homo sapiens dihydropyridine receptor alpha 2 subunit (CACNA2D1) gene, exon 1
      gi|6090576|gb|AF083817.1|HSDRA2S01[6090576]
    • 9716: U68492
      Homo sapiens 5-hydroxytryptamine 7 receptor isoform B gene, alternatively spliced, partial cds
      gi|1857150|gb|U68492.1|HS5HTSEV01[1857150]
    • 9717: AB032417
      Homo sapiens FZD4 mRNA for WNT receptor Frizzled-4, complete cds
      gi|6277265|dbj|AB032417.1|AB032417[6277265]
    • 9718: AF191093
      Homo sapiens P2X4 purinoceptor gene, complete cds
      gi|6274470|gb|AF191093.1|AF191093[6274470]
    • 9719: AJ130713
      Homo sapiens mRNA for QA79 membrane protein, splice product airm-1
      gi|5541875|emb|AJ130713.1|HSA130713[5541875]
    • 9720: AJ130712
      Homo sapiens mRNA for QA79 membrane protein, splice product airm-3
      gi|5541873|emb|AJ130712.1|HSA130712[5541873]
    • 9721: AJ130711
      Homo sapiens mRNA for QA79 membrane protein, splice product airm-2
      gi|5541871|emb|AJ130711.1|HSA130711[5541871]
    • 9722: AJ130710
      Homo sapiens mRNA for QA79 membrane protein, allelic variant airm-1b
      gi|5541869|emb|AJ130710.1|HSA130710[5541869]
    • 9723: AJ007395
      Homo sapiens mRNA for QA79 membrane protein
      gi|5295849|emb|AJ007395.1|HSA7395[5295849]
    • 9724: X95097
      Homo sapiens mRNA for VIP receptor 2
      gi|4837717|emb|X95097.2|HSVIP2R[4837717]
    • 9725: Y18423
      Homo sapiens VIP2R gene, exons 1-2 (and joined CDS)
      gi|4753150|emb|Y18423.1|HA18423[4753150]
    • 9726: Y18431
      Homo sapiens VIP2R gene, exon 13
      gi|4741409|emb|Y18431.1|HA18431[4741409]
    • 9727: Y18430
      Homo sapiens VIP2R gene, exons 9-12
      gi|4741408|emb|Y18430.1|HA18430[4741408]
    • 9728: Y18429
      Homo sapiens VIP2R gene, exon 8
      gi|4741407|emb|Y18429.1|HA18429[4741407]
    • 9729: Y18428
      Homo sapiens VIP2R gene, exon 7
      gi|4741406|emb|Y18428.1|HA18428[4741406]
    • 9730: Y18427
      Homo sapiens VIP2R gene, exon 6
      gi|4741405|emb|Y18427.1|HA18427[4741405]
    • 9731: Y18426
      Homo sapiens VIPR2 gene exon 5
      gi|4741404|emb|Y18426.1|HA18426[4741404]
    • 9732: Y18425
      Homo sapiens VIPR2 gene exon 4
      gi|4741403|emb|Y18425.1|HA18425[4741403]
    • 9733: Y18424
      Homo sapiens VIPR2 gene exon 3
      gi|4741402|emb|Y18424.1|HA18424[4741402]
    • 9734: X57250
      H. sapiens C5aR mRNA for C5 anaphylatoxin receptor
      gi|29569|emb|X57250.1|HSC5AR[29569]
    • 9735: AF200348
      Homo sapiens melanoma-associated antigen MG50 mRNA, partial cds
      gi|6273398|gb|AF200348.1|AF200348[6273398]
    • 9736: AH008357
      Homo sapiens coxsackievirus B-adenovirus receptor (CAR) gene, exon 1
      gi|6224699|gb|AH008357.1|SEG_HSCXADR[6224699]
    • 9737: AF169366
      Homo sapiens coxsackievirus B-adenovirus receptor (CAR) gene, exon 7 and complete cds
      gi|6224698|gb|AF169366.1|HSCXADR7[6224698]
    • 9738: AF169365
      Homo sapiens coxsackievirus B-adenovirus receptor (CAR) gene, exon 6
      gi|6224697|gb|AF169365.1|HSCXADR6[6224697]
    • 9739: AF169364
      Homo sapiens coxsackievirus B-adenovirus receptor (CAR) gene, exon 5
      gi|6224696|gb|AF169364.1|HSCXADR5[6224696]
    • 9740: AF169363
      Homo sapiens coxsackievirus B-adenovirus receptor (CAR) gene, exon 4
      gi|6224695|gb|AF169363.1|HSCXADR4[6224695]
    • 9741: AF169362
      Homo sapiens coxsackievirus B-adenovirus receptor (CAR) gene, exon 3
      gi|6224694|gb|AF169362.1|HSCXADR3[6224694]
    • 9742: AF169361
      Homo sapiens coxsackievirus B-adenovirus receptor (CAR) gene, exon 2
      gi|6224693|gb|AF169361.1|HSCXADR2[6224693]
    • 9743: AF169360
      Homo sapiens coxsackievirus B-adenovirus receptor (CAR) gene, exon 1
      gi|6224692|gb|AF169360.1|HSCXADR1[6224692]
    • 9744: AF181862
      Homo sapiens G protein-coupled receptor mRNA, complete cds
      gi|6175912|gb|AF181862.1|AF181862[6175912]
    • 9745: AF178632
      Homo sapiens FEM-1-like death receptor binding protein mRNA, complete cds
      gi|6175868|gb|AF178632.1|AF178632[6175868]
    • 9755: X80763
      Homo sapiens gene for 5-hydroxytrptamine 2C receptor, exons 1 to 4
      gi|602872|emb|X80763.1|HS5HT2C[602872]
    • 9756: X68149
      Homo sapiens BLR1 gene for Burkitt's lymphoma receptor 1
      gi|29459|emb|X68149.1|HSBLR1A[29459]
    • 9757: AF187320
      Homo sapiens transferrin receptor (TFRC) gene, complete cds
      gi|6164847|gb|AF187320.1|AF187320[6164847]
    • 9758: AF154673
      Homo sapiens olfactory receptor HPFH1OR (HPFH1OR) gene, complete cds
      gi|5764388|gb|AF154673.1|AF154673[5764388]
    • 9760: AF169255
      Homo sapiens 5-hydroxytryptamine 3 receptor B subunit (5-HTR3B) mRNA, complete
      cds
      gi|6103620|gb|AF169255.1|AF169255[6103620]
    • 9762: AJ133107
      Homo sapiens CD163 gene, exon 17
      gi|5102659|emb|AJ133107.1|HSA133107[5102659]
    • 9763: Y18403
      Homo sapiens CD163 gene, exon 16
      gi|5102656|emb|Y18403.1|HSA118403[5102656]
    • 9764: Y18402
      Homo sapiens CD163 gene, exon 15
      gi|5102655|emb|Y18402.1|HSA118402[5102655]
    • 9765: Y18401
      Homo sapiens CD163 gene, exon 14
      gi|5102654|emb|Y18401.1|HSA118401[5102654]
    • 9766: Y18400
      Homo sapiens CD163 gene, exon 13
      gi|5102653|emb|Y18400.1|HSA118400[5102653]
    • 9767: Y18399
      Homo sapiens CD163 gene, exon 12
      gi|5102652|emb|Y18399.1|HSA118399[5102652]
    • 9768: Y18398
      Homo sapiens CD163 gene, exon 11
      gi|5102651|emb|Y18398.1|HSA118398[5102651]
    • 9769: Y18397
      Homo sapiens CD163 gene, exon 10
      gi|5102650|emb|Y18397.1|HSA118397[5102650]
    • 9770: Y18396
      Homo sapiens CD163 gene, exon 9
      gi|5102649|emb|Y18396.1|HSA118396[5102649]
    • 9771: Y18395
      Homo sapiens CD163 gene, exon 8
      gi|5102648|emb|Y18395.1|HSA118395[5102648]
    • 9772: Y18394
      Homo sapiens CD163 gene, exon 7
      gi|5102647|emb|Y18394.1|HSA118394[5102647]
    • 9773: Y18393
      Homo sapiens CD163 gene, exon 6
      gi|5102646|emb|Y18393.1|HSA118393[5102646]
    • 9774: Y18392
      Homo sapiens CD163 gene, exon 5
      gi|5102645|emb|Y18392.1|HSA118392[5102645]
    • 9775: Y18391
      Homo sapiens CD163 gene, exon 4
      gi|5102644|emb|Y18391.1|HSA118391[5102644]
    • 9776: Y18390
      Homo sapiens CD163 gene, exon 3
      gi|5102643|emb|Y18390.1|HSA118390[5102643]
    • 9777: Y18389
      Homo sapiens CD163 gene, exon 2
      gi|5102642|emb|Y18389.1|HSA118389[5102642]
    • 9791: AF095725
      Homo sapiens PAC LLNLP704E02527Q3 olfactory receptor 17-1 (OR17-1), olfactory receptor 17-2 (OR17-2), olfactory receptor 17-201 (OR17-201), and olfactory receptor 17-93 (OR17-93) genes, complete cds
      gi|6090622|gb|AF095725.1|AF095725[6090622]
    • 9792: AH007997
      Homo sapiens prostaglandin E2 receptor EP2 subtype (PTGER2) gene, complete cds
      gi|5524234|gb|AH007997.1|SEG_HSPTGER2G[5524234]
    • 9793: AF134202
      Homo sapiens prostaglandin E2 receptor EP2 subtype (PTGER2) gene, alternatively
      spliced exons and complete cds
      gi|5524233|gb|AF134202.1|HSPTGER2G2[5524233]
    • 9794: AF134201
      Homo sapiens prostaglandin E2 receptor EP2 subtype (PTGER2) gene, exon 1
      gi|5524232|gb|AF134201.1|HSPTGER2G1[5524232]
    • 9797: AF139768
      Homo sapiens type II transmembrane protein MDL-1 (MDL1) mRNA, complete cds
      gi|6049175|gb|AF139768.1|AF139768[6049175]
    • 9799: X75318
      H. sapiens ITIH1 gene (exon 22) and ITIH3 gene (exon 1 and joining features)
      gi|575256|emb|X75318.1|HSITIH[575256]
    • 9800: AJ245822
      Homo sapiens mRNA for type I transmembrane receptor (psk-3 gene)
      gi|6018463|emb|AJ245822.1|HSA245822[6018463]
    • 9801: AJ245820
      Homo sapiens mRNA for type I transmembrane receptor (psk-1 gene)
      gi|6018459|emb|AJ245820.1|HSA245820[6018459]
    • 9802: L46722
      Homo sapiens BTG1 binding factor 1 (CAF1) mRNA, complete cds
      gi|6016011|gb|L46722.1|L46722[6016011]
    • 9803: X87831
      Homo sapiens mRNA for partial OCT/plexin-A2 protein
      gi|6010214|emb|X87831.2|HSOCTPROT[6010214]
    • 9804: AJ000994
      Homo sapiens DNA for p58 NK receptor gene
      gi|2764562|emb|AJ000994.1|HSP58NK[2764562]
    • 9805: X84761
      H. sapiens LHCGR gene, exon 9
      gi|1225992|emb|X84761.1|HSLHCGRX9[1225992]
    • 9806: X84760
      H. sapiens LHCGR gene, exon 8
      gi|1225991|emb|X84760.1|HSLHCGRX8[1225991]
    • 9807: X84759
      H. sapiens LHCGR gene, exon 7
      gi|1225990|emb|X84759.1|HSLHCGRX7[1225990]
    • 9808: X84758
      H. sapiens LHCGR gene, exon 6
      gi|1225989|emb|X84758.1|HSLHCGRX6[1225989]
    • 9809: X84757
      H. sapiens LHCGR gene, exon 5
      gi|1225988|emb|X84757.1|HSLHCGRX5[1225988]
    • 9810: X84756
      H. sapiens LHCGR gene, exon 4
      gi|1225987|emb|X84756.1|HSLHCGRX4[1225987]
    • 9811: X84754
      H. sapiens LHCGR gene, exon 2
      gi|1225985|emb|X84754.1|HSLHCGRX2[1225985]
    • 9812: X84753
      H. sapiens LHCGR gene, exon 1
      gi|1225983|emb|X84753.1|HSLHCGRX1[1225983]
    • 9813: X84763
      H. sapiens LHCGR gene, exon 11
      gi|1225982|emb|X84763.1|HSLHCGR111[1225982]
    • 9814: X84762
      H. sapiens LHCGR gene, exon 10
      gi|1225981|emb|X84762.1|HSLHCGR10[1225981]
    • 9815: AF140631
      Homo sapiens G-protein coupled receptor 14 (GPR14) gene, complete cds
      gi|5902615|gb|AF140631.1|AF140631[5902615]
    • 9816: AF140630
      Homo sapiens urotensin-II mRNA, complete cds
      gi|5902613|gb|AF140630.1|AF140630[5902613]
    • 9817: AF040752
      Homo sapiens G protein-coupled receptor kinase 6, splice variant C (GRK6) mRNA,
      complete cds
      gi|3005017|gb|AF040752.1|AF040752[3005017]
    • 9818: AF040751
      Homo sapiens G protein-coupled receptor kinase 6, splice variant B (GRK6) mRNA,
      complete cds
      gi|3005015|gb|AF040751.1|AF040751[3005015]
    • 9819: AF040753
      Homo sapiens G protein-coupled receptor kinase 6 (GRK6) gene, partial cds
      gi|3004990|gb|AF040753.1|AF040753[3004990]
    • 9820: X87832
      Homo sapiens mRNA for partial NOV/plexin-A1 protein
      gi|6010216|emb|X87832.2|HSNOVPROT[6010216]
    • 9821: X87904
      Homo sapiens mRNA for semaphorin receptor (plexin-B1/SEP gene)
      gi|6010210|emb|X87904.2|HSRNASEP[6010210]
    • 9822: AJ011415
      Homo sapiens mRNA for plexin-B1 plasma membrane receptor, splice variant R (plexin-B1/SEP gene)
      gi|5918166|emb|AJ011415.1|HSA011415[5918166]
    • 9823: AJ011414
      Homo sapiens mRNA for plexin-B1 plasma membrane receptor, truncated splice variant (plexin-B1/SEP gene)
      gi|5918164|emb|AJ011414.1|HSA011414[5918164]
    • 9824: X07019
      Homo sapiens partial TRDC gene for T-cell receptor delta chain, exon 1
      gi|29766|emb|X07019.1|HSCD1G[29766]
    • 9825: X54559
      Homo sapiens mRNA for met proto-oncogene
      gi|34557|emb|X54559.1|HSMETPRO[34557]
    • 9826: AF186380
      Homo sapiens calcium-mobilizing lysophosphatidic acid receptor LP-A3/Edg-7 mRNA,
      complete cds
      gi|6003655|gb|AF186380.1|AF186380[6003655]
    • 9827: AF147204
      Homo sapiens chemokine receptor CXCR4-Lo (CXCR4) mRNA, alternatively spliced, complete cds
      gi|6002763|gb|AF147204.1|AF147204[6002763]
    • 9828: AF029213
      Homo sapiens IL-1 receptor accessory protein mRNA, complete cds
      gi|2599126|gb|AF029213.1|AF029213[2599126]
    • 9829: Z24462
      H. sapiens MTCP-1 gene
      gi|406858|emb|Z24462.1|HSMTCP1B[406858]
    • 9830: Z24455
      H. sapiens MTCP-1 gene
      gi|406857|emb|Z24455.1|HSMTCP1A[406857]
    • 9832: AF124598
      Homo sapiens coxsackie and adenovirus receptor protein (HCAR2) mRNA, partial cds
      gi|4884701|gb|AF124598.1|AF124598[4884701]
    • 9833: AF124145
      Homo sapiens autocrine motility factor receptor (AMFR) mRNA, complete cds
      gi|5931954|gb|AF124145.1|AF124145[5931954]
    • 9835: AF118637
      Homo sapiens feline leukemia virus subgroup C receptor FLVCR(C10) mRNA, complete cds
      gi|5565871|gb|AF118637.1|AF118637[5565871]
    • 9836: AF127138
      Homo sapiens lysophosphatidic acid G protein-coupled receptor (EDG7) mRNA, complete cds
      gi|5922724|gb|AF127138.1|AF127138[5922724]
    • 9837: AF104939
      Homo sapiens lectomedin-1 gamma (LEC1) mRNA, complete cds
      gi|5880493|gb|AF104939.1|AF104939[5880493]
    • 9838: AF104266
      Homo sapiens lectomedin-1 alpha (LEC1) mRNA, complete cds
      gi|5880489|gb|AF104266.1|AF104266[5880489]
    • 9839: X51646
      Homo sapiens DRD2 gene for dopamine receptor D2
      gi|30868|emb|X51646.1|HSDOPD2GE[30868]
    • 9840: X51645
      Homo sapiens mRNA for dopamine receptor D2 (DRD2 gene)
      gi|30867|emb|X51645.1|HSDOPD2[30867]
    • 9841: AB010447
      Homo sapiens mRNA for CC chemokine eotaxin3, complete cds
      gi|5921130|dbj|AB010447.1|AB010447[5921130]
    • 9844: AF137378
      Homo sapiens integrin alpha 11 subunit precursor (ITGA11) mRNA, complete cds
      gi|5915661|gb|AF137378.2|AF137378[5915661]
    • 9845: AJ243212
      Homo sapiens mRNA for DMBT1 protein 8 kb transcript variant 2 (DMBT1/8 kb.2)
      gi|5912463|emb|AJ243212.1|HSA243212[5912463]
    • 9846: AJ243874
      Homo sapiens mRNA for oligophrenin-4 (OPHN4 gene)
      gi|5911829|emb|AJ243874.1|HSA243874[5911829]
    • 9847: AF091352
      Homo sapiens vascular permeability factor 148 mRNA, complete cds
      gi|5901560|gb|AF091352.1|AF091352[5901560]
    • 9848: AF159456
      Homo sapiens gp-340 variant protein (DMBT1) mRNA, complete cds
      gi|5733597|gb|AF159456.1|AF159456[5733597]
    • 9948: AB023486
      Homo sapiens gene for histamine H2 receptor, promoter region and complete cds
      gi|5881575|dbj|AB023486.1|AB023486[5881575]
    • 9949: AF104938
      Homo sapiens lectomedin-1 beta (LEC1) mRNA, complete cds
      gi|588049|gb|AF104938.1|AF104938[5880491]
    • 9950: U81379
      Homo sapiens interleukin-13 receptor mRNA, complete cds
      gi|5870850|gb|U81379.3|HSU81379[5870850]
    • 9951: AH008056
      Homo sapiens galanin receptor (GALR3) gene, complete cds
      gi|5870844|gb|AH008056.2|SEG_HSGALR3S[5870844]
    • 9952: AF129514
      Homo sapiens galanin receptor (GALR3) gene, exon 2 and complete cds
      gi|5870843|gb|AF129514.2|HSGALR3S2[5870843]
    • 9953: AF129513
      Homo sapiens galanin receptor (GALR3) gene, exon 1
      gi|5870842|gb|AF129513.2|HSGALR3S1[5870842]
    • 9954: AF101472
      Homo sapiens G protein-coupled receptor 75 (GPR75) gene, complete cds
      gi|4558866|gb|AF101472.1|AF101472[4558866]
    • 9955: AF072693
      Homo sapiens G protein-coupled receptor 75 (GPR75) mRNA, complete cds
      gi|4406084|gb|AF072693.1|AF072693[4406084]
    • 9957: AJ246000
      Homo sapiens mRNA for leucocyte adhesion receptor, L-selectin
      gi|5852071|emb|AJ246000.1|HSA246000[5852071]
    • 9959: AJ224864
      Homo sapiens mRNA for IRC1 protein
      gi|5834585|emb|AJ224864.1|HSA224864[5834585]
    • 9960: AJ132948
      Homo sapiens mRNA for rfg7 protein, partial
      gi|5834581|emb|AJ132948.1|HSA132948[5834581]
    • 9961: AB027464
      Homo sapiens FZD10 mRNA for Frizzled-10, complete cds
      gi|5834487|dbj|AB027464.1|AB027464[5834487]
    • 9963: AJ133532
      Homo sapiens mRNA for dendritic cell immunoreceptor
      gi|5823973|emb|AJ133532.1|HSA133532[5823973]
    • 9964: AJ223153
      Homo sapiens mRNA for activating NK-A1 receptor
      gi|5823969|emb|AJ223153.1|HSAJ3153[5823969]
    • 9965: AB025257
      Homo sapiens FCER1B gene for high affinity IgE receptor beta chain, promoter region, partial sequence
      gi|5821396|dbj|AB025257.1|AB025257[5821396]
    • 9970: Y16434
      Homo sapiens mRNA for T-cell receptor beta, clone PPN82
      gi|2879843|emb|Y16434.1|HSTCRB82[2879843]
    • 9971: Y16433
      Homo sapiens mRNA for T-cell receptor alpha, clone PPN82
      gi|2879842|emb|Y16433.1|HSTCRA82[2879842]
    • 9972: AF144648
      Homo sapiens GABA-A receptor theta (theta) mRNA, complete cds
      gi|5764186|gb|AF144648.1|AF144648[5764186]
    • 9973: AF151104
      Homo sapiens T-cell receptor gamma gene sequence
      gi|5758137|gb|AF151104.1|AF151104[5758137]
    • 9974: AF039686
      Homo sapiens G-protein coupled receptor GPR34 (GPR34) mRNA, complete cds
      gi|5757633|gb|AF039686.1|AF039686[5757633]
    • 9975: AF000548
      Homo sapiens P1 clone DMPC-HFF#1-1075-D9, repeat region
      gi|223207|gb|AF000548.1|HSAF000548[2232071]
    • 9976: X83701
      Homo sapiens IGF2R gene (subclone pE3UP)
      gi|929648|emb|X83701.1|HSIGF2RX3[929648]
    • 9977: X83700
      Home sapiens IGF2R gene (subclone pEX2)
      gi|929646|emb|X83700.1|HSIGF2RX2[929646]
    • 9978: X83702
      Homo sapiens IGF2R gene (subclone pEX3)
      gi|929644|emb|X83702.1|HSIGF2R1 3[929644]
    • 9979: G16210
      967A10R CEPH YAC and mega-YAC libraries (DBThompson) Homo sapiens STS genomic clone 967A10, sequence tagged site
      gi|1592382|gb|G16210.1|G16210[1592382]
    • 9980: AH008077
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, complete cds
      gi|5737745|gb|AH008077.1|SEG_HSEDAR[5737745]
    • 9981: AF130996
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, exon 12 and complete
      cds
      gi|5737744|gb|AF130996.1|HSEDAR8[5737744]
    • 9982: AF130995
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, exon 11
      gi|5737743|gb|AF130995.1|HSEDAR7[5737743]
    • 9983: AF130994
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, exon 10
      gi|5737742|gb|AF130994.1|HSEDAR6[5737742]
    • 9984: AF130993
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, exons 7, 8, and 9
      gi|573774|gb|AF130993.1|HSEDAR5[5737741]
    • 9985: AF130992
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, exon 6
      gi|5737740|gb|AF130992.1|HSEDAR4[5737740]
    • 9986: AF130991
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, exon 5
      gi|5737739|gb|AF130991.1|HSEDAR3[5737739]
    • 9987: AF130990
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, exons 2, 3, and 4
      gi|5737738|gb|AF130990.1|HSEDAR2[5737738]
    • 9988: AF130989
      Homo sapiens ectodysplasin-A receptor protein (EDAR) gene, exon 1
      gi|5737737|gb|AF130989.1|HSEDAR1[5737737]
    • 9989: AF130988
      Homo sapiens ectodysplasin-A receptor protein (EDAR) mRNA, complete cds
      gi|5737735|gb|AF130988.1|AF130988[5737735]
    • 9990: AF033111
      Homo sapiens Siva-2 mRNA, complete cds
      gi|5737690|gb|AF033111.1|AF033111[5737690]
    • 9992: AJ238044
      Homo sapiens mRNA for bradykinin B1 receptor (BLBKR gene)
      gi|5139485|emb|AJ238044.1|HSA238044[5139485]
    • 9993: X95425
      H. sapiens mRNA for EHK-1 receptor tyrosine kinase
      gi|1177465|emb|X95425.1|HSEHK1[1177465]
    • 9995: AF135562
      Homo sapiens p58 killer cell inhibitory receptor KIR-K78 (KIR-K78) mRNA, partial
      cds
      gi|5730925|gb|AF135562.1|AF135562[5730925]
    • 9996: AF135561
      Homo sapiens p58 killer cell inhibitory receptor KIR-K65 (KIR-K65) mRNA, partial
      cds
      gi|5730923|gb|AF135561.1(AF135561[5730923]
    • 9997: AF135560
      Homo sapiens p58 killer cell inhibitory receptor KIR-K64 (KIR-K64) mRNA, partial
      cds
      gi|5730921|gb|AF135560.1|AF135560[5730921]
    • 9998: AF135559
      Homo sapiens p58 killer cell inhibitory receptor KIR-K61 (KIR-K61) mRNA, partial
      cds
      gi|5730919|gb|AF135559.1|AF135559[5730919]
    • 9999: AF135558
      Homo sapiens p58 killer cell inhibitory receptor KIR-K39 (KIR-K39) mRNA, partial
      cds
      gi|5730917|gb|AF135558.1|AF135558[5730917]
    • 10000: AF135557
      Homo sapiens p58 killer cell inhibitory receptor KIR-K36 (KIR-K36) mRNA, partial
      cds
      gi|5730915|gb|AF135557.1|AF135557[5730915]
    • 10001: AF135556
      Homo sapiens p58 killer cell inhibitory receptor KIR-K15 (KIR-K15) mRNA, partial
      cds
      gi|5730913|gb|AF135556.1|AF135556[5730913]
    • 10002: AF135555
      Homo sapiens p58 killer cell inhibitory receptor KIR-K9 (KIR-K9) mRNA, partial
      cds
      gi|5730911|gb|AF135555.1|AF135555[5730911]
    • 10003: AF135554
      Homo sapiens p58 killer cell inhibitory receptor KIR-K3 (KIR-K3) mRNA, partial
      cds
      gi|5730909|gb|AF135554.1|AF135554[5730909]
    • 10004: AF135567
      Homo sapiens p58 killer cell inhibitory receptor KIR-K7c mRNA, alternatively spliced, partial cds
      gi|5730907|gb|AF135567.1|AF135567[5730907]
    • 10005: AF135566
      Homo sapiens p58 killer cell inhibitory receptor KIR-K7b mRNA, alternatively spliced, partial cds
      gi|5730905|gb|AF135566.1|AF135566[5730905]
    • 10006: AF135565
      Homo sapiens p58 killer cell inhibitory receptor KIR-K7a mRNA, alternatively spliced, partial cds
      gi|5730903|gb|AF135565.1|AF135565[5730903]
    • 10007: AF135564
      Homo sapiens p50 killer cell activating receptor KAR-K1d mRNA, alternatively spliced, partial cds
      gi|5730901|gb|AF135564.1|AF135564[5730901]
    • 10008: AF135563
      Homo sapiens p50 killer cell activating receptor KAR-K1a mRNA, alternatively spliced, partial cds
      gi|5730899|gb|AF135563.1|AF135563[5730899]
    • 10009: AF172932
      Homo sapiens MIS type II receptor (MISRII) mRNA, complete cds
      gi|5726642|gb|AF172932.1|AF172932[5726642]
    • 10010: AF162790
      Homo sapiens Fc gamma receptor III-A gene, partial cds
      gi|5726469|gb|AF162790.1|AF162790[5726469]
    • 10012: AF161921
      Homo sapiens clone G7 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712813|gb|AF161921.1|[5712813]
    • 10013: AF161920
      Homo sapiens clone G6 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712812|gb|AF161920.1|[5712812]
    • 10014: AF161919
      Homo sapiens clone F4 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712811|gb|AF161919.1|[5712811]
    • 10015: AF161918
      Homo sapiens clone F3 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712810|gb|AF161918.1|[5712810]
    • 10016: AF161917
      Homo sapiens clone F1.1 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712809|gb|AF161917.1|[5712809]
    • 10017: AF161916
      Homo sapiens clone H-JM-2 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712808|gb|AF161916.1|[5712808]
    • 10018: AF161915
      Homo sapiens clone JM-1 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712807|gb|AF161915.1|[5712807]
    • 10019: AF161914
      Homo sapiens clone 9/8.2 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712806|gb|AF161914.1|[5712806]
    • 10020: AF161913
      Homo sapiens clone 6-53 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712805|gb|AF161913.1|[5712805]
    • 10021: AF161912
      Homo sapiens clone 5-53 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712804|gb|AF161912.1|[5712804]
    • 10022: AF161911
      Homo sapiens clone 4-55 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712803|gb|AF161911.1|[5712803]
    • 10023: AF161910
      Homo sapiens clone 4-53 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712802|gb|AF161910.1|[5712802]
    • 10024: AF161909
      Homo sapiens clone 3-55 C-C chemokine receptor 5 (CCR5) mRNA, partial cds
      gi|5712801|gb|AF161909.1|[5712801]
    • 10025: E17202
      Human cDNA for JEG18 complete cds
      gi|5711885|dbj|E17202.1|E17202[5711885]
    • 10026: E17201
      Human mRNA for JEG18 complete cds
      gi|5711884|dbj|E17201.1|E17201[5711884]
    • 10027: E16188
      cDNA encoding G protein-coupled receptor
      gi|5710871|dbj|E16188.1|E16188[5710871]
    • 10028: E16187
      Partial sequence of cDNA encoding G protein-coupled receptor
      gi|5710870|dbj|E16187.1|E16187[5710870]
    • 10029: E16186
      Partial sequence of cDNA encoding G protein-coupled receptor
      gi|5710869|dbj|E16186.1|E16186[5710869]
    • 10030: E16000
      EST sequence containing human G protein-coupling receptor gene
      gi|5710683|dbj|E6000.1|E16000[5710683]
    • 10031: E15999
      EST sequence containing human G protein-coupling receptor gene
      gi|5710682|dbj|E15999.1|E15999[5710682]
    • 10032: E15998
      cDNA encoding G protein-coupling receptor protein
      gi|5710681|dbj|E15998.1|E15998[5710681]
    • 10033: E15997
      cDNA encoding human G protein-coupling receptor protein
      gi|5710680|dbj|E15997.1|E15997[5710680]
    • 10034: E15919
      cDNA encoding prostaglandin EP3-6 receptor
      gi|5710602|dbj|E15919.1|E15919[5710602]
    • 10035: E15918
      cDNA encoding prostaglandin EP3-5 receptor
      gi|5710601|dbj|E15918.1|E15918[5710601]
    • 10037: E15242
      Human mRNA for endothelin B receptor, complete cds
      gi|5709925|dbj|E15242.1|E15242[5709925]
    • 10038: E14946
      Human mRNA for adrenaline beta 3 receptor
      gi|5709629|dbj|E14946.1|E14946[5709629]
    • 10039: E14587
      Human mRNA isoform fragment for Vitamin D receptor
      gi|5709270|dbj|E14587.1|E14587[5709270]
    • 10040: E14586
      Human mRNA isoform fragment for Vitamin D receptor
      gi|5709269|dbj|E14586.1|E14586[5709269]
    • 10041: E14585
      Human mRNA isoform for Vitamin D receptor
      gi|5709268|dbj|E14585.1|E14585[5709268]
    • 10042: E14219
      Partial sequence of human cDNA encoding a G protein-coupled receptor, 63A2full
      gi|5708902|dbj|E14219.1|E14219[5708902]
    • 10043: E14218
      Partial sequence of human cDNA encoding a G protein-coupled receptor, 63A2full
      gi|5708901|dbj|E14218.1|E14218[5708901]
    • 10044: E14217
      Human mRNA for a G protein-coupled receptor, 63A2full, complete cds
      gi|5708900|dbj|E14217.1|E14217[5708900]
    • 10046: X83699
      Homo sapiens IGF2R gene (subclone pEX1-P)
      gi|1006660|emb|X83699.1|HSIGF2RX1[1006660]
    • 10048: AF007790
      Homo sapiens ICERE-1 mRNA, complete cds
      gi|5670325|gb|AF007790.2|AF007790[5670325]
    • 10054: AF036718
      Homo sapiens FGFR signalling adaptor SNT-2 mRNA, complete cds
      gi|2708629|gb|AF036718.1|AF036718[2708629]
    • 10056: AF099033
      Homo sapiens gamma-aminobutyric acid type B receptor 2 (GABABR2) mRNA, complete
      cds
      gi|5639666|gb|AF099033.1|AF099033[5639666]
    • 10057: AF009221
      Homo sapiens leucocyte immunoglobulin-like receptor-1 mRNA, complete cds
      gi|2267169|gb|AF009221.1|AF009221[2267169]
    • 10058: AF009220
      Homo sapiens leucocyte immunoglobulin-like receptor-1 mRNA, complete cds
      gi|2267167|gb|AF009220.1|AF009220[2267167]
    • 10059: AF067864
      Homo sapiens transferrin receptor 2 alpha (TFR2) mRNA, complete cds
      gi|5596369|gb|AF067864.1|AF067864[5596369]
    • 10061: AF040257
      Homo sapiens TNF receptor homolog mRNA, partial cds
      gi|3170220|gb|AF040257.1|AF040257[3170220]
    • 10062: AF026245
      Homo sapiens yotiao mRNA, complete cds
      gi|2623067|gb|AF026245.1|AF026245[2623067]
    • 10064: AF163302
      Homo sapiens somatostatin receptor interacting protein splice variant a (SSTRIP)
      mRNA, complete cds
      gi|5533304|gb|AF163302.1|AF163302[5533304]
    • 10065: AF153500
      Homo sapiens mu opioid receptor (MOR1) gene, partial cds
      gi|5524612|gb|AF153500.1|AF153500[5524612]
    • 10066: AH007996
      Homo sapiens NK receptor Ly-49L gene, complete cds
      gi|5524171|gb|AH007996.1|SEG_HSLY49L[5524171]
    • 10067: AF126038
      Homo sapiens NK receptor Ly-49L gene, pseudoexon 7
      gi|5524170|gb|AF126038.1|HSLY49L3[5524170]
    • 10068: AF126037
      Homo sapiens NK receptor Ly-49L gene, exon 5, pseudoexon 6, and complete cds
      gi|5524169|gb|AF126037.1|HSLY49L2[5524169]
    • 10069: AF126036
      Homo sapiens NK receptor Ly-49L gene, exons 1 through 4
      gi|5524168|gb|AF126036.1|HSLY49L1[5524168]
    • 10070: AF081675
      Homo sapiens ITIM-containing receptor MAFA-L mRNA, complete cds
      gi|3421400|gb|AF081675.1|AF081675[3421400]
    • 10071: AF145782
      Homo sapiens 2B4 type I transmembrane protein mRNA, complete cds
      gi|5059179|gb|AF145782.1|AF145782[5059179]
    • 10072: AH007960
      Homo sapiens receptor tyrosine kinase (EPHAL) gene, complete cds
      gi|5453121|gb|AH007960.1|SEG_HSEPHAI[5453121]
    • 10073: AF101171
      Homo sapiens receptor tyrosine kinase (EPHAL) gene, exon 18 and complete cds
      gi|5453120|gb|AF101171.1|HSEPHA17[5453120]
    • 10074: AF101170
      Homo sapiens receptor tyrosine kinase (EPHAL) gene, exon 17
      gi|5453119|gb|AF101170.1|HSEPHA16[5453119]
    • 10075: AF101169
      Homo sapiens receptor tyrosine kinase (EPHAL) gene, exons 12 through 16
      gi|5453118|gb|AF101169.1|HSEPHA15[5453118]
    • 10076: AF101168
      Homo sapiens receptor tyrosine kinase (EPHAL) gene, exons 4 through 11
      gi|5453117|gb|AF101168.1|HSEPHA14[5453117]
    • 10077: AF101167
      Homo sapiens receptor tyrosine kinase (EPHAL) gene, exon 3
      gi|5453116|gb|AF101167.1|HSEPHA13[5453116]
    • 10078: AF101166
      Homo sapiens receptor tyrosine kinase (EPHAL) gene, exon 2
      gi|5453115|gb|AF101166.1|HSEPHA12[5453115]
    • 10079: AF101165
      Homo sapiens receptor tyrosine kinase (EPHAL) gene, exon 1
      gi|5453114|gb|AF101165.1|HSEPHA11[5453114]
    • 10080: AF107761
      Homo sapiens NK cell receptor (2B4) mRNA, complete cds
      gi|5442467|gb|AF107761.2|AF107761[5442467]
    • 10081: AF109127
      Homo sapiens stromal cell-derived receptor-1 alpha mRNA, complete cds
      gi|5442037|gb|AF109127.1|AF109127[5442037]
    • 10082: AF109126
      Homo sapiens stromal cell-derived receptor-1 beta mRNA, complete cds
      gi|5442035|gb|AF109126.1|AF109126[5442035]
    • 10084: Y17131
      Homo sapiens FGFR2 gene, exon 7 and exon 8 (partial)
      gi|3077606|emb|Y17131.1|HSY17131[3077606]
    • 10085: X57829
      H. sapiens serotonin 5-HT1a receptor gene
      gi|36428|emb|X57829.1|HSSERR51[36428]
    • 10086: AF100762
      Homo sapiens thyroid receptor interactor trip15 mRNA, complete cds
      gi|5410309|gb|AF100762.1|TRIP15[5410309]
    • 10087: AF109388
      Homo sapiens P2X2B receptor mRNA, complete cds
      gi|5381338|gb|AF109388.1|AF109388[5381338]
    • 10088: AF109387
      Homo sapiens P2X2A receptor mRNA, complete cds
      gi|5381336|gb|AF109387.1|AF109387[5381336]
    • 10089: AF118108
      Homo sapiens lymphatic endothelium-specific hyaluronan receptor LYVE-1 mRNA, complete cds
      gi|5359672|gb|AF118108.1|AF118108[5359672]
    • 10090: AF119711
      Homo sapiens cysLT1 LTD4 receptor (CYSLT1) mRNA, complete cds
      gi|5353886|gb|AF119711.1|AF119711[5353886]
    • 10091: X72861
      H. sapiens gene for beta-3-adrenergic receptor
      gi|298094|emb|X72861.1|HSB3A[298094]
    • 10092: AF103906
      Homo sapiens vanilloid receptor-like protein (VRL) mRNA, complete cds
      gi|5305597|gb|AF103906.1|AF103906[5305597]
    • 10093: AF072873
      Homo sapiens frizzled 6 mRNA, complete cds
      gi|5305408|gb|AF072873.1|AF072873[5305408]
    • 10095: AF153437
      Homo sapiens haplotype val92met/A942G melanocortin 1 receptor (MC1R) gene, complete cds
      gi|5257473|gb|AF153437.1|AF153437[5257473]
    • 10096: AF153436
      Homo sapiens haplotype A942G melanocortin 1 receptor (MC1R) gene, complete cds
      gi|5257472|gb|AF153436.1|AF153436[5257472]
    • 10097: AF153435
      Homo sapiens haplotype arg67gln/arg163gln melanocortin 1 receptor (MC1R) gene,
      complete cds
      gi|525747|gb|AF153435.1|AF153435[5257471]
    • 10098: AF153434
      Homo sapiens haplotype arg163gln melanocortin 1 receptor (MC1R) gene, complete
      cds
      gi|5257470|gb|AF153434.1|AF153434[5257470]
    • 10099: AF153433
      Homo sapiens haplotype arg151cys melanocortin 1 receptor (MC1R) gene, complete
      cds
      gi|5257469|gb|AF153433.1|AF153433[5257469]
    • 10100: AF153432
      Homo sapiens haplotype asp84glu melanocortin 1 receptor (MC1R) gene, complete cds
      gi|5257468|gb|AF153432.1|AF153432[5257468]
    • 10101: AF153431
      Homo sapiens melanocortin 1 receptor (MC1R) gene, complete cds
      gi|5257467|gb|AF153431.1|AF153431[5257467]
    • 10103: AH007879
      Homo sapiens macrophage receptor (MARCO) gene, complete cds
      gi|5231091|gb|AH007879.1|SEG_HSMARCO[5231091]
    • 10104: AF128186
      Homo sapiens macrophage receptor (MARCO) gene, exon 17 and complete cds
      gi|5231090gb|AF128186.1|HSMARCO15[5231090]
    • 10105: AF128185
      Homo sapiens macrophage receptor (MARCO) gene, exon 16
      gi|5231089|gb|AF128185.1|HSMARCO14[5231089]
    • 10106: AP128184
      Homo sapiens macrophage receptor (MARCO) gene, exon 15
      gi|5231088|gb|AF128184.1|HSMARCO13[5231088]
    • 10107: AF128183
      Homo sapiens macrophage receptor (MARCO) gene, exon 14
      gi|5231087|gb|AF128183.1|HSMARCO12[5231087]
    • 10108: AF128182
      Homo sapiens macrophage receptor (MARCO) gene, exon 13
      gi|5231086|gb|AF128182.1|HSMARCO11[5231086]
    • 10109: AF128181
      Homo sapiens macrophage receptor (MARCO) gene, exons 11 and 12
      gi|5231085|gb|AF128181.1|HSMARCO10[5231085]
    • 10110: AF128180
      Homo sapiens macrophage receptor (MARCO) gene, exons 9 and 10
      gi|5231084|gb|AF128180.1|HSMARCO09[5231084]
    • 10111: AF128179
      Homo sapiens macrophage receptor (MARCO) gene, exon 8
      gi|5231083|gb|AF128179.1|HSMARCO08[5231083]
    • 10112: AF128178
      Homo sapiens macrophage receptor (MARCO) gene, exon 7
      gi|5231082|gb|AF128178.1|HSMARCO07[5231082]
    • 10113: AF128177
      Homo sapiens macrophage receptor (MARCO) gene, exon 6
      gi|5231081|gb|AF128177.1|HSMARCO06[5231081]
    • 10114: AF128176
      Homo sapiens macrophage receptor (MARCO) gene, exon 5
      gi|5231080|gb|AF128176.1|HSMARCO05[5231080]
    • 10115: AF128175
      Homo sapiens macrophage receptor (MARCO) gene, exon 4
      gi|5231079|gb|AF128175.1|HSMARCO04[5231079]
    • 10116: AF128174
      Homo sapiens macrophage receptor (MARCO) gene, exon 3
      gi|5231078|gb|AF128174.1|HSMARCO03[5231078]
    • 10117: AF128173
      Homo sapiens macrophage receptor (MARCO) gene, exon 2
      gi|5231077|gb|AF128173.1|HSMARCO02[5231077]
    • 10118: AF128172
      Homo sapiens macrophage receptor (MARCO) gene, exon 1
      gi|5231076|gb|AF128172.1|HSMARCO01[5231076]
    • 10140: D50855
      Human mRNA for Ca-sensing receptor, complete cds
      gi|904209|dbj|D50855.1|HUMCASR[904209]
    • 10141: D49783
      Human gene for histamine H2 receptor, complete cds
      gi|728495|dbj|D49783.1|HUMHH2R[728495]
    • 10142: D16826
      Human gene for fourth somatostatin receptor subtype
      gi|693907|dbj|D16826.1|HUMSSTR4[693907]
    • 10143: D29984
      Human mRNA for monocyte chemoattractant protein 1 receptor (MCP-1 receptor), complete cds
      gi|531246|dbj|D529984.1|HUMMCP1R[531246]
    • 10144: D14436
      Human gene for histamine H1-receptor, complete cds
      gi|506335|dbj|D514436.1|HUMHH1RE[506335]
    • 10145: D16827
      Human gene for fifth somatostatin receptor subtype
      gi|487683|dbj|D516827.1|HUMSSTR5[487683]
    • 10146: D14717
      Human mRNA for large erk kinase
      gi|285916|dbj|D514717.1|HUMERK[285916]
    • 10147: AF073515
      Homo sapiens cytokine type 1 receptor CRLP-1 precursor, mRNA, complete cds
      gi|5106394|gb|AF073515.1|AF073515[5106394]
    • 10148: AH007696
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, partial cds; fibroblast growth factor receptor 2 Ksam IV secreted isoform (FGFR2) gene, complete cds; fibroblast growth factor receptor (FGFR2) gene, alternative splice
      products, partial cds; and fibroblast growth factor receptor 2 (FGFR2) gene, partial cds
      gi|4808621|gb|AH007696.1|SEG_HSFGFR2A[4808621]
    • 10149: AF097354
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 20, alternative splice products and partial cds
      gi|4808620|gb|AF097354.1|HSFGFR2A19[4808620]
    • 10150: AF097353
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 19, alternative splice products and partial cds
      gi|4808619|gb|AF097353.1|HSFGFR2A18[4808619]
    • 10151: AF097352
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 18
      gi|4808618|gb|AF097352.1|HSFGFR2A17[4808618]
    • 10152: AF097351
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 17
      gi|4808617|gb|AF097351.1|HSFGFR2A16[4808617]
    • 10153: AF097350
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 16
      gi|4808616|gb|AF097350.1|HSFGFR2A15[4808616]
    • 10154: AF097349
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 15
      gi|4808615|gb|AF097349.1|HSFGFR2A14[4808615]
    • 10155: AF097348
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 14
      gi|4808614|gb|AF097348.1|HSFGFR2A13[4808614]
    • 10156: AF097347
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 13
      gi|4808613|gb|AF097347.1|HSFGFR2A12[4808613]
    • 10157: AF097346
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 12
      gi|4808612|gb|AF097346.1|HSFGFR2A11[4808612]
    • 10158: AF097345
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exons 11 and 11′
      gi|4808611|gb|AF097345.1|HSFGFR2A10[4808611]
    • 10159: AF097344
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 10
      gi|4808610|gb|AF097344.1|HSFGFR2A09[4808610]
    • 10160: AF097343
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 9
      gi|4808609|gb|AF097343.1|HSFGFR2A08[4808609]
    • 10161: AF097342
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 8
      gi|4808608|gb|AF097342.1|HSFGFR2A07[4808608]
    • 10162: AF097341
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exons 6 and 7, alternative splice products and partial cds
      gi|4808607|gb|AF097341.1|HSFGFR2A06[4808607]
    • 10163: AF097340
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 5, alternative splice products and partial cds
      gi|4808606|gb|AF097340.1|HSFGFR2A05[4808606]
    • 10164: AF097339
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 4
      gi|4808605|gb|AF097339.1|HSFGFR2A04[4808605]
    • 10165: AF097338
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 3
      gi|4808604|gb|AF097338.1|HSFGFR2A03[4808604]
    • 10166: AF097337
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 2
      gi|4808603|gb|AF097337.1|HSFGFR2A02[4808603]
    • 10167: AF097336
      Homo sapiens fibroblast growth factor receptor 2 (FGFR2) gene, exon 1
      gi|4808602|gb|AF097336.1|HSFGFR2A01[4808602]
    • 10168: U58146
      Homo sapiens alternatively spliced interleukin-6 receptor beta chain mRNA, partial cds
      gi|2253597|gb|U58146.1|HSU58146[2253597]
    • 10169: AF134395
      Homo sapiens CARD-like apoptotic protein (CLAP) mRNA, complete cds
      gi|5070371|gb|AF134395.1|AF134395[5070371]
    • 10170: AF015044
      Homo sapiens EH-binding protein mRNA, partial cds
      gi|4102712|gb|AF015044.1|AF015044[4102712]
    • 10171: AF015043
      Homo sapiens EH-binding protein mRNA, partial cds
      gi|4102710|gb|AF015043.1|AF015043[4102710]
    • 10172: AF145207
      Homo sapiens CCR9 chemokine receptor (CCR9) mRNA, partial cds
      gi|5052417|gb|AF145207.1|AF145207[5052417]
    • 10173: AB018549
      Homo sapiens MD-2 mRNA, complete cds
      gi|5051739|dbj|AB018549.1|AB018549[5051739]
    • 10174: AH007443
      Homo sapiens chromosome 19 clone cosmid R31931 map 19q13.4
      gi|4322573|gb|AH007443.1|SEG_HSCD89S[4322573]
    • 10175: AF091544
      Homo sapiens myeloid FcalphaRI (CD89) gene, 3′ sequence
      gi|4322572|gb|AF091544.1|HSCD89S2[4322572]
    • 10177: AF152962
      Homo sapiens somatostatin receptor type 5 (SSTR5) gene, promoter region and partial cds
      gi|5031446|gb|AF152962.1|AF152962[5031446]
    • 10178: AF140538
      Homo sapiens histamine H3 receptor mRNA, complete cds
      gi|5031290|gb|AF140538.1|AF140538[5031290]
    • 10179: AJ238896
      Homo sapiens partial RAGE gene, exons 9 to 11
      gi|4867820|emb|AJ238896.1|HSA238896[4867820]
    • 10180: AF039904
      Homo sapiens cosmid D56B10, chromosome 21 5′ of IFNAR1
      gi|2853622|gb|AF039904.1|AF039904[2853622]
    • 10181: AF039905
      Homo sapiens cosmid Q95D4, chromosome 21 5′ of IFNAR2
      gi|2766549|gb|AF039905.1|AF039905[2766549]
    • 10182: AF039907
      Homo sapiens cosmid Q50G2, chromosome 21 3′ of IFNAR1
      gi|2754858|gb|AF039907.1|AF039907[2754858]
    • 10183: AB020807
      Homo sapiens mRNA for TLR6, complete cds
      gi|5006247|dbj|AB020807.1|AB020807[5006247]
    • 10184: AF144308
      Homo sapiens putative G protein-coupled receptor (DL1R) mRNA, complete cds
      gi|4959876|gb|AF144308.1|AF144308[4959876]
    • 10185: AF107262
      Homo sapiens central cannabinoid receptor (CB1K5) mRNA, complete cds
      gi|4959366|gb|AF107262.1|AF107262[4959366]
    • 10263: AH007742
      Homo sapiens neuronal acetylcholine receptor beta-3 subunit precursor (CHRNB3)
      gene, complete cds
      gi|4927249|gb|AH007742.1|SEG_HSCHRNB[4927249]
    • 10264: AF140765
      Homo sapiens neuronal acetylcholine receptor beta-3 subunit precursor (CHRNB3)
      gene, exon 6 and complete cds
      gi|4927248|gb|AF140765.1|HSCHRNB6[4927248]
    • 10265: AF140764
      Homo sapiens neuronal acetylcholine receptor beta-3 subunit precursor (CHRNB3)
      gene, exon 5
      gi|4927247|gb|AF140764.1|HSCHRNB5[4927247]
    • 10266: AF140763
      Homo sapiens neuronal acetylcholine receptor beta-3 subunit precursor (CHRNB3)
      gene, exon 4
      gi|4927246|gb|AF140763.1|HSCHRNB4[4927246]
    • 10267: AF140762
      Homo sapiens neuronal acetylcholine receptor beta-3 subunit precursor (CHRNB3)
      gene, exon 3
      gi|4927245|gb|AF140762.1|HSCHRNB3[4927245]
    • 10268: AF140761
      Homo sapiens neuronal acetylcholine receptor beta-3 subunit precursor (CHRNB3)
      gene, exon 2
      gi|49272441gb|AF140761.1|HSCHRNB2[4927244]
    • 10269: AF140760
      Homo sapiens neuronal acetylcholine receptor beta-3 subunit precursor (CHRNB3)
      gene, exon 1
      gi|4927243|gb|AF140760.1|HSCHRNB1[4927243]
    • 10270: U19261
      Homo sapiens Epstein-Barr virus-induced protein mRNA, complete cds
      gi|675461|gb|U19261.1|HSU19261[675461]
    • 10272: AF105261
      Homo sapiens natural killer cell receptor 2B4 mRNA, complete cds
      gi|4894519|gb|AF105261.1|AF105261[4894519]
    • 10273: AH007727
      Homo sapiens prolactin receptor gene, complete cds
      gi|4886767|gb|AH007727.1|SEG_HSPLR[4886767]
    • 10274: AF091870
      Homo sapiens prolactin receptor gene, alternatively spliced, exon 10 and complete cds
      gi|4886766|gb|AF091870.1|HSPLR12[4886766]
    • 10275: AF091869
      Homo sapiens prolactin receptor gene, exon 9
      gi|4886765|gb|AF091869.1|HSPLR11[4886765]
    • 10276: AF091868
      Homo sapiens prolactin receptor gene, exon 8
      gi|4886764|gb|AF091868.1|HSPLR10[4886764]
    • 10277: AF091867
      Homo sapiens prolactin receptor gene, exon 7
      gi|4886763|gb|AF091867.1|HSPLR09[4886763]
    • 10278: AF091866
      Homo sapiens prolactin receptor gene, exon 6
      gi|4886762|gb|AF091866.1|HSPLR08[4886762]
    • 10279: AF091865
      Homo sapiens prolactin receptor gene, exon 5
      gi|4886761|gb|AF091865.1|HSPLR07[4886761]
    • 10280: AF091864
      Homo sapiens prolactin receptor gene, exon 4
      gi|4886760|gb|AF091864.1|HSPLR06[4886760]
    • 10281: AF091863
      Homo sapiens prolactin receptor gene, exon 3
      gi|4886759|gb|AF091863.1|HSPLR05[4886759]
    • 10282: AF091862
      Homo sapiens prolactin receptor gene, exon 2
      gi|4886758|gb|AF091862.1|HSPLR04[4886758]
    • 10283: AF091859
      Homo sapiens prolactin receptor gene, promoter region and alternative exons 1
      gi|4886757|gb|AF091859.1|HSPLR01[4886757]
    • 10284: AJ132337
      Homo sapiens mRNA for chemokine receptor CCR9
      gi|4886431|emb|AJ132337.1|HSA132337[4886431]
    • 10285: AF120152
      Mus musculus cytokine receptor-like molecule 9 (Creme9) mRNA, complete cds
      gi|4884628|gb|AF120152.1|AF120152[4884628]
    • 10286: AF120151
      Homo sapiens cytokine receptor-like molecule 9 (CREME9) mRNA, complete cds
      gi|4884626|gb|AF120151.1|AF120151[4884626]
    • 10287: D13814
      Homo sapiens mRNA for angiotensin II type 1b receptor, complete cds
      gi|471120|dbj|D13814.1|HUMAGRT1B[471120]
    • 10288: AJ236922
      Homo sapiens mRNA for metabotropic glutamate receptor 8c
      gi|4456479|emb|AJ236922.1|HSA236922[4456479]
    • 10289: AJ236921
      Homo sapiens mRNA for metabotropic glutamate receptor 8b
      gi|4456477|emb|AJ236921.1HSA236921[4456477]
    • 10478: AF106858
      Homo sapiens G-protein-coupled receptor (GPR56) mRNA, complete cds
      gi|4836764|gb|AF106858.1|AF106858[4836764]
    • 10479: AF095784
      Homo sapiens GABA-B receptor R2 (GABBR2) mRNA, complete cds
      gi|4836217|gb|AF095784.1|AF095784[4836217]
    • 10500: AJ006520
      Homo sapiens mRNA for m1 muscarinic acetylcholine receptor protein, partial
      gi|3292964|emb|AJ006520.1|HSA6520[3292964]
    • 10693: AF110907
      Homo sapiens TNF-receptor associated factor-3 (TRAF-3) gene, exons 1a and 1b, complete sequence
      gi|4761208|gb|AF110907.1|AF110907[4761208]
    • 10694: AJ002425
      Homo sapiens mRNA for p65 protein
      gi|4753767|emb|AJ002425.2|HSAJ2425[4753767]
    • 10697: Y15220
      Homo sapiens mRNA for chemokine IP-9
      gi|4225953|emb|Y15220.1|HSCHIP9RN[4225953]
    • 10698: AJ005282
      Homo sapiens mRNA for NPR-B1
      gi|3059110|emb|AJ005282.1|HSAJ5282[3059110]
    • 10699: AJ012188
      Homo sapiens mRNA for GABAB receptor, subunit 2
      gi|3776097|emb|AJ012188.1|HSA012188[3776097]
    • 10700: AJ012187
      Homo sapiens mRNA for GABAB receptor, subunit 1c,
      gi|3776095|emb|AJ012187.1|HSA012187[3776095]
    • 10701: AJ012186
      Homo sapiens mRNA for GABAB receptor, subunit 1b
      gi|3776093|emb|AJ012186.1|HSA012186[3776093]
    • 10702: AJ012185
      Homo sapiens mRNA for GABAB-receptor, subunit 1a
      gi|3776072|emb|AJ012185.1|HSA012185[3776072]
    • 10704: AF129112
      Homo sapiens vanilloid receptor-like protein 1 (VRL-1) mRNA, complete cds
      gi|4589140|gb|AF129112.1|AF129112[4589140]
    • 10705: AF068265
      Homo sapiens monocyte chemoattractant protein 1 receptor (CCR2) gene promoter and mRNA, partial sequence
      gi|4587865|gb|AF068265.1|AF068265[4587865]
    • 10706: AB020625
      Homo sapiens mRNA for butyrophilin like receptor, complete cds
      gi|4587208|dbj|AB020625.1|AB020625[4587208]
    • 10709: AH007576
      Homo sapiens killer cell inhibitory receptor G9P gene, complete cds
      gi|4581764|gb|AH007576.1|SEG_HSKIRG9P[4581764]
    • 10710: AF110035
      Homo sapiens killer cell inhibitory receptor G9P gene, complete cds
      gi|4581763|gb|AF110035.1|HSKIRG9P4[4581763]
    • 10711: AF110034
      Homo sapiens killer cell inhibitory receptor G9P gene, partial sequence
      gi|4581762|gb|AF110034.1|HSKIRG9P3[4581762]
    • 10712: AF110033
      Homo sapiens killer cell inhibitory receptor G9P gene, partial sequence
      gi|4581761|gb|AF110033.1HSKIRG9P2[4581761]
    • 10713: AF110032
      Homo sapiens killer cell inhibitory receptor G9P gene, partial sequence
      gi|4581760|gb|AF110032.1|HSKIRG9 P1[4581760]
    • 10714: AF114165
      Homo sapiens endothelin receptor B delta 3 mRNA, complete cds
      gi|4580923|gb|AF114165.1|AF114165[4580923]
    • 10717: AF105999
      Homo sapiens acetylcholine receptor epsilon subunit (CHRNE) gene, complete cds
      gi|4580858|gb|AF105999.1|AF105999[4580858]
    • 10718: AH007573
      Homo sapiens killer inhibitory receptor 1 (KIR1) gene, complete cds; and kill inhibitory receptor 2 (KIR2) gene, partial cds
      gi|4580703|gb|AH007573.1|SEG_HS2KIR[4580703]
    • 10720: AF134316
      Homo sapiens killer inhibitory receptor 4-1-2 (KIR412) gene, exon 5 and partial
      cds
      gi|4580701|gb|AF134316.1|SEG_HS2KIR7[4580701]
    • 10721: AF134315
      Homo sapiens killer inhibitory receptor 4-1-2 (KIR412) gene, exon 4
      gi|4580700|gb|AF134315.1|SEG_HS2KIR6[4580700]
    • 10723: AF134313
      Homo sapiens killer inhibitory receptor 4-1-2 (KIR412) gene, exon 2 and pseudoexon 3
      gi|4580698|gb|AF134313.1|SEG_HS2KIR4[4580698]
    • 10724: AF134312
      Homo sapiens killer inhibitory receptor 4-1-1 (KIR411) gene, exons 7, 8 and 9
      and partial cds; killer inhibitory receptor 4-1-2 (KIR412) gene, exon 1
      gi|4580697|gb|AF134312.1|SEG_HS2KIR3[4580697]
    • 10725: AF134311
      Homo sapiens killer inhibitory receptor 4-1-1 (KIR411) gene, exon 6
      gi|4580696|gb|AF134311.1|SEG_HS2KIR2[4580696]
    • 10727: AH007572
      Homo sapiens killer inhibitory receptor (KIR) gene, partial cds
      gi|4580693|gb|AH007572.1|SEG_HSKIRP[4580693]
    • 10728: AF133900
      Homo sapiens killer inhibitory receptor cl 2-3 (KIRCL23) gene, exons 7, 8, and 9
      and partial cds
      gi|4580692|gb|AF133900.1|HSKIRP5[4580692]
    • 10729: AF133899
      Homo sapiens killer inhibitory receptor cl 2-3 (KIRCL23) gene, exon 6
      gi|4580691|gb|AF133899.1|HSKIRP4[4580691]
    • 10730: AF133898
      Homo sapiens killer inhibitory receptor cl 2-3 (KIRCL23) gene, exon 5
      gi|4580690|gb|AF133898.1|HSKIRP3[4580690]
    • 10731: AF133897
      Homo sapiens killer inhibitory receptor cl 2-3 (KIRCL23) gene, exon 4
      gi|4580689|gb|AF133897.1|HSKIRP2[4580689]
    • 10732: AF133896
      Homo sapiens killer inhibitory receptor cl 2-3 (KIRCL23) gene, pseudoexon 3
      gi|4580688|gb|AF133896.1|HSKIRP1[4580688]
    • 10733: AF133901
      Homo sapiens killer inhibitory receptor 2-2-1 (KIR221) and killer inhibitory receptor 2-2-2 (KIR222) genes, partial cds
      gi|4580682|gb|AF133901.1|AF133901[4580682]
    • 10736: AF069755
      Homo sapiens orphan G protein-coupled receptor HG20 (HG20) mRNA, complete cds
      gi|4091932|gb|AF069755.1|AF069755[4091932]
    • 10738: AC007229
      Homo sapiens chromosome 19, cosmid R34187, complete sequence
      gi|4567173|gb|AC007229.1|AC007229[4567173]
    • 10740: AF125303
      Homo sapiens glucocorticoid-induced TNFR-related protein ligand (TNFSF18) mRNA,
      complete cds
      gi|4558500|gb|AF125303.1|AF125303[4558500]
    • 10742: AF058762
      Homo sapiens galanin receptor subtype 2 (GALNR2) gene, complete cds
      gi|3170598|gb|AF058762.1|AF058762[3170598]
    • 10743: AF096786
      Homo sapiens chromosome 2 G protein-coupled receptor (GPR55) gene, complete cds
      gi|4545136|gb|AF096786.1|AF096786[4545136]
    • 10745: AF096784
      Homo sapiens chromosome 1 G protein-coupled receptor (GPR52) gene, complete cds
      gi|4545133|gb|AF096784.1|AF096784[4545133]
    • 10746: AF119815
      Homo sapiens G-protein coupled receptor (NPGPR) mRNA, complete cds
      gi|4530468|gb|AF119815.1|AF119815[4530468]
    • 10749: AF098664
      Homo sapiens olfactory receptor-like protein (OR2C1) gene, complete cds
      gi|3982606|gb|AF098664.1|AF098664[3982606]
    • 10752: AF090131
      Homo sapiens clone b312C2EN9 LDL receptor-related protein 6 gene, partial cds,
      and CpG island sequence
      gi|4494988|gb|AF090131.1|AF090131[4494988]
    • 10778: X95583
      H. sapiens mRNA for monocyte chemotactic protein-1 (MCP-1) receptor
      gi|4468944|emb|X95583.1|HSMCP1REC[4468944]
    • 10791: AJ131757
      Homo sapiens olr1 gene
      gi|4468343|emb|AJ131757.1|HSA131757[4468343]
    • 10792: X58674
      H. sapiens RNA for receptor for C5a anaphylatoxin
      gi|29568|emb|X58674.1|HSC5ANAPL[29568]
    • 10793: U51134
      Homo sapiens calcitonin gene-related peptide receptor component protein mRNA, complete cds
      gi|4097252|gb|U51134.1|HSU51134[4097252]
    • 10794: Y13464
      Homo sapiens mRNA for cholecystokinin B receptor
      gi|3287189|emb|Y13464.1|HSY13464[3287189]
    • 10795: Z66558
      H. sapiens FAS/Apo1 gene (Del B1 mutation; partial)
      gi|150414|embo Z66558.1|HSFASAPOC[1150414]
    • 10796: Z66557
      H. sapiens of FAS/Apo1 gene (partial)
      gi|150413|emb|Z66557.1|HSFASAPOB[1150413]
    • 10797: Z66556
      H. sapiens FASExo8Del mRNA
      gi|11150412emb|Z66556.1|HSFASAPOA[1150412]
    • 10825: AF118266
      Homo sapiens orphan G protein-coupled receptor GPR45 (GPR45) gene, complete cds
      gi|4455062|gb|AF118266.1|AF118266[4455062]
    • 10826: AF118265
      Homo sapiens orphan G protein-coupled receptor GPR44 (GPR44) gene, complete cds
      gi|4455060|gb|AF118265.1|AF118265[4455060]
    • 10827: Y18046
      Homo sapiens mRNA for FOP (FGFR1 oncogene partner)
      gi|4454262|emb|Y18046.1|HSAY18046[4454262]
    • 10828: AJ006276
      Homo sapiens mRNA for transient receptor potential protein TRP6
      gi|4454260|emb|AJ006276.1|HSAJ6276[4454260]
    • 10829: M13918
      Homo sapiens fibronectin receptor alpha-subunit precursor (ITGA5) mRNA, partial
      cds
      gi|4464190|gb|M13918.2|HUMFNRAS[4464190]
    • 10831: D13515
      Homo sapiens mRNA for key subunit of N-methyl-D-aspartate receptor, complete cds
      gi|219919|dbj|D13515.1|HUMMARR[219919]
    • 10832: D10583
      Homo sapiens mRNA for IgE receptor beta subunit, complete cds
      gi|219881|dbj|D10583.1|HUMIGERB[219881]
    • 10834: AH007490
      Homo sapiens gibbon ape leukemia virus receptor 1 (SLC20A1) gene, partial cds
      gi|4416260|gb|AH007490.1|SEG_HSGLVR1G[4416260]
    • 10835: AF102063
      Homo sapiens gibbon ape leukemia virus receptor 1 (SLC20A1) gene, exon 11 and complete cds
      gi|4416259|gb|AF102063.1|HSGLVR1G5[4416259]
    • 10836: AF102062
      Homo sapiens gibbon ape leukemia virus receptor 1 (SLC20A1) gene, exons 7 through 10
      gi|4416258|gb|AF102062.1|HSGLVR1G4[4416258]
    • 10837: AF102061
      Homo sapiens gibbon ape leukemia virus receptor 1 (SLC20A1) gene, exon 6
      gi|4416257|gb|AF102061.1|HSGLVR1G3[4416257]
    • 10838: AF102060
      Homo sapiens gibbon ape leukemia virus receptor 1 (SLC20A1) gene, exon 5
      gi|4416256|gb|AF102060.1|HSGLVR1G2[4416256]
    • 10839: AF102059
      Homo sapiens gibbon ape leukemia virus receptor 1 (SLC20A1) gene, exons 1 through 4
      gi|4416255|gb|AF102059.1|HSGLVR1G1[4416255]
    • 10840: AF098798
      Homo sapiens unknown mRNA
      gi|4416073|gb|AF098798.1|AF098798[4416073]
    • 10841: AF118670
      Homo sapiens orphan G protein-coupled receptor (GPR34) gene, complete cds
      gi|4325085|gb|AF118670.1|AF118670[4325085]
    • 10842: AF053072
      Homo sapiens GABA subunit A receptor alpha 6 precursor, gene, partial cds
      gi|4405812|gb|AF053072.1|AF053072[4405812]
    • 10843: AF052539
      Homo sapiens chemokine receptor 5 (CCR5) gene, CCR5—CYS allele, complete cds
      gi|4337455|gb|AF052539.1|AF052539[4337455]
    • 10844: AF117713
      Homo sapiens AITR ligand (TL6) mRNA, complete cds
      gi|4378801|gb|AF117713.1|AF117713[4378801]
    • 10845: AF117297
      Homo sapiens TNF receptor superfamily activation-inducible protein mRNA, complete cds
      gi|4378799|gb|AF117297.1|AF117297[4378799]
    • 10974: Z29585
      H. sapiens gene for high affinity IgE receptor alpha chain
      gi|452350|emb|Z29585.1|HSHAIGER[452350]
    • 10975: AF050154
      Homo sapiens clone F19374 APO E-C2 gene cluster, complete sequence
      gi|4105701|gb|AF050154.1|AF050154[4105701]
    • 10981: X97881
      H. sapiens mRNA for G protein coupled receptor kinase, GRK4D
      gi|1770427|emb|X97881.1|HSGRK4D[1770427]
    • 10982: X97880
      H. sapiens mRNA for G protein coupled receptor kinase, GRK4C
      gi|1770425|emb|X97880.1|HSGRK4C[1770425]
    • 10983: X97879
      H. sapiens mRNA for G protein coupled receptor kinase, GRK4B
      gi|1770423|emb|X97879.1|HSGRK4B[1770423]
    • 10984: AJ007787
      Homo sapiens CHRNA3 gene, exon 6, partial
      gi|4164387|emb|AJ007787.1|HSA7787[4164387]
    • 10985: AJ007786
      Homo sapiens CHRNA3 gene, exon 5
      gi|4164386|emb|AJ007786.1|HSA7786[4164386]
    • 10986: AJ007785
      Homo sapiens CHRNA3 gene, exon 4
      gi|4164383|emb|AJ007785.1|HSA7785[4164383]
    • 10987: AJ007784
      Homo sapiens CHRNA3 gene, exons 2 to 3
      gi|4164382|emb|AJ007784.1|HSA7784[4164382]
    • 10988: AJ007783
      Homo sapiens CHRNA3 gene, exon 1 and joined CDS
      gi|4164380|emb|AJ007783.1|HSA7783[4164380]
    • 10989: AJ001939
      Homo sapiens CHRNB2 gene, exon 6
      gi|3766463|emb|AJ001939.1|HSAJ1939[3766463]
    • 10990: AJ001938
      Homo sapiens CHRNB2 gene, exon 5
      gi|3766454|emb|AJ001938.1|HSAJ1938[3766454]
    • 10991: AJ001937
      Homo sapiens CHRNB2 gene, exon 4
      gi|3766453|emb|AJ001937.1|HSAJ1937[3766453]
    • 10992: AJ001936
      Homo sapiens CHRNB2 gene, exon 2 and exon 3
      gi|3766452|emb|AJ001936.1|HSAJ1936[3766452]
    • 10993: AJ001935
      Homo sapiens CHRNB2 gene, exon 1 (and joined CDS)
      gi|3766450|emb|AJ001935.1|HSAJ1935[3766450]
    • 10998: AJ003147
      Homo sapiens complete genomic sequence between D16S3070 and D16S3275, containing
      Familial Mediterranean Fever gene disease
      gi|2808656|emb|AJ003147.1|HSAJ03147[2808656]
    • 11000: AJ225029
      Homo sapiens mRNA for GABA-B R1b receptor
      gi|3892873|emb|AJ225029.1|HSA225029[3892873]
    • 11004: AJ003147
      Homo sapiens complete genomic sequence between D16S3070 and D16S3275, containing
      Familial Mediterranean Fever gene disease
      gi|2808656|emb|AJ003147.1|HSAJ03147[2808656]
    • 11006: AJ225029
      Homo sapiens mRNA for GABA-B R1b receptor
      gi|3892873|emb|AJ225029.1|HSA225029[3892873]
    • 11007: AJ225028
      Homo sapiens mRNA for GABA-B R1a receptor
      gi|3892593|emb|AJ225028.1|HSA225028[3892593]
    • 11092: AJ132194
      Homo sapiens olfr89 gene
      gi|4160227|emb|AJ132194.1|HSA132194[4160227]
    • 11093: AJ012753
      Homo sapiens RAGE gene (partial), exon 2
      gi|4034482|emb|AJ012753.1|HSA012753[4034482]
    • 11094: AJ012332
      Homo sapiens IL-1R gene cluster PAC contig, centromeric STS, sequence tagged site
      gi|4128031|emb|AJ012332.1|HSA012332[4128031]
    • 11095: AJ012331
      Homo sapiens IL-1R gene cluster PAC contig, telomeric STS, sequence tagged site
      gi|4128030|emb|AJ012331.1|HSA012331[4128030]
    • 11097: AJ011701
      Homo sapiens TRHR gene promoter and exons 1-2, partial
      gi|4128016|emb|AJ011701.1|HSA011701[4128016]
    • 11098: AJ010191
      Homo sapiens gababr1 receptor gene, exon 18
      gi|3980509|emb|AJ010191.1|HSA010191[3980509]
    • 11099: AJ010190
      Homo sapiens gababr1 receptor gene, exon 17
      gi|3980507|emb|AJ010190.1|HSA010190[3980507]
    • 11100: AJ010189
      Homo sapiens gababr1 receptor gene, exon 16
      gi|3980504|emb|AJ010189.1|HSA010189[3980504]
    • 11101: AJ010188
      Homo sapiens gababr1 receptor gene, exon 15
      gi|3980502|emb|AJ010188.1|HSA010188[3980502]
    • 11102: AJ010187
      Homo sapiens gababr1 receptor gene, exon 14
      gi|3980500|emb|AJ010187.1|HSA010187[3980500]
    • 11103: AJ010186
      Homo sapiens gababr1 receptor gene, exon 13
      gi|3980498|emb|AJ010186.1|HSA010186[3980498]
    • 11104: AJ010185
      Homo sapiens gababr1 receptor gene, exon 12
      gi|3980496|emb|AJ010185.1|HSA010185[3980496]
    • 11105: AJ010184
      Homo sapiens gababr1 receptor gene, exon 11
      gi|3980494|emb|AJ010184.1|HSA010184[3980494]
    • 11106: AJ010183
      Homo sapiens gababr1 receptor gene, exon 10
      gi|3980492|emb|AJ010183.1|HSA010183[3980492]
    • 11107: AJ010182
      Homo sapiens gababr1 receptor gene, exon 9
      gi|3980490|emb|AJ010182.1|HSA010182[3980490]
    • 11108: AJ010181
      Homo sapiens gababr1 receptor gene, exon 8
      gi|3980488|emb|AJ010181.1|HSA010181[3980488]
    • 11109: AJ010180
      Homo sapiens gababr1 receptor gene, exon 7
      gi|3980486|emb|AJ010180.1|HSA010180[3980486]
    • 11110: AJ010179
      Homo sapiens gababr1 receptor gene, exon 6
      gi|3980484|emb|AJ010179.1|HSA010179[3980484]
    • 11111: AJ010178
      Homo sapiens gababr1 receptor gene, exon 5
      gi|3980482|emb|AJ010178.1|HSA010178[3980482]
    • 11112: AJ010177
      Homo sapiens gababr1 receptor gene, exon 4
      gi|3980481|emb|AJ010177.1|HSA010177[3980481]
    • 11113: AJ010176
      Homo sapiens gababr1 receptor gene, exon 3
      gi|3980480|emb|AJ010176.1|HSA010176[3980480]
    • 11114: AJ010175
      Homo sapiens gababr1 receptor gene, exon 2
      gi|3980479|emb|AJ010175.1|HSA010175[3980479]
    • 11115: AJ010174
      Homo sapiens gababr1 receptor gene, exon 1
      gi|3980477|emb|AJ010174.1|HSA010174[3980477]
    • 11116: AJ010173
      Homo sapiens gababr1 receptor gene, exon 1a4
      gi|3980475|emb|AJ010173.1|HSA010173[3980475]
    • 11117: AJ010172
      Homo sapiens gababr1 receptor gene, exon 1a3
      gi|3980472|emb|AJ010172.1|HSA010172[3980472]
    • 11118: AJ010171
      Homo sapiens gababr1 receptor gene, exon 1a2
      gi|3980469|emb|AJ010171.1|HSA10171[3980469]
    • 11119: AJ010170
      Homo sapiens gababr1 receptor gene, exon 1a1
      gi|3980465|emb|AJ010170.1|HSA10170[3980465]
    • 11121: AF061022
      Homo sapiens CTH gene, complete cds
      gi|4335930|gb|AF061022.1|AF061022[4335930]
    • 11122: AF052041
      Homo sapiens olfactory receptor gene cluster, complete sequence
      gi|4335873|gb|AF052041.1|AF052041[4335873]
    • 11124: AC006953
      Homo sapiens chromosome 19, cosmid R28316, complete sequence
      gi|4335701|gb|AC006953.1|AC006953[4335701]
    • 11125: AF105367
      Homo sapiens glucagon-like peptide-2 receptor precursor (GLP2R) mRNA, complete
      cds
      gi|4324490|gb|AF105367.1|AF105367[4324490]
    • 11434: AH007439
      Homo sapiens chromosome X
      gi|4322454|gb|AH007439.1|SEG_HSIL2RGIN[4322454]
    • 11435: AF085452
      Homo sapiens interleukin-2 receptor gamma chain (IL2RG) gene, intron 5, partial
      sequence
      gi|4322453|gb|AF085452.1|HSIL2RGIN2[4322453]
    • 11436: AF085451
      Homo sapiens interleukin-2 receptor gamma chain (IL2RG) gene, intron 4, partial
      sequence
      gi|4322452|gb|AF085451.1|HSIL2RGIN1[4322452]
    • 11437: AF065213
      Homo sapiens advanced glycosylation end product-specific receptor (RAGE) gene,
      intron 3, partial sequence
      gi|4321945|gb|AF065213.1|AF065213[4321945]
    • 11438: AF065212
      Homo sapiens patient M1 advanced glycosylation end product-specific receptor (RAGE) gene, exon 3 and partial cds
      gi|4321943|gb|AF065212.1|AF065212[4321943]
    • 11439: AF065211
      Homo sapiens patient M21 advanced glycosylation end product-specific receptor (RAGE) gene, exon 3 and partial cds
      gi|4321941|gb|AF065211.1|AF065211[4321941]
    • 11440: AF065210
      Homo sapiens patient M20 advanced glycosylation end product-specific receptor (RAGE) gene, exon 3 and partial cds
      gi|4321939|gb|AF0652101.1|AF065210[4321939]
    • 11441: AF051305
      Homo sapiens beta chemokine receptor (CCR1) gene, promoter region and exon 1
      gi|4321648|gb|AF051305.1|AF051305[4321648]
    • 11442: U87223
      Homo sapiens contactin associated protein (Caspr) mRNA, complete cds
      gi|1857707|gb|U87223.1|HSU87223[1857707]
    • 11443: AF022386
      Homo sapiens p53-regulated DNA damage-inducible cell death receptor (killer) mRNA, complete cds
      gi|2460427|gb|AF022386.1|AF022386[2460427]
    • 11444: AF011368
      Homo sapiens CEV14 mRNA, partial cds
      gi|2618824|gb|AF011368.1|AF011368[2618824]
    • 11445: AF016267
      Homo sapiens TRAIL receptor 3 mRNA, complete cds
      gi|2529564|gb|AF016267.1|AF016267[2529564]
    • 11446: AF020502
      Homo sapiens cytotoxic TRAIL receptor-3 (TRAIL-R3) mRNA, complete cds
      gi|2443819|gb|AF020502.1|AF020502[2443819]
    • 11447: AF020501
      Homo sapiens cytotoxic TRAIL receptor-2 (DR5) mRNA, complete cds
      gi|2443817|gb|AF020501.1|AF020501[2443817]
    • 11454: AF075460
      Homo sapiens type 1-like ryanodine receptor mRNA, partial cds
      gi|3328200|gb|AF075460.1|AF075460[3328200]
    • 11455: AF054830
      Homo sapiens interleukin-1 type I receptor mRNA, partial sequence
      gi|3003026|gb|AF054830.1|AF054830[3003026]
    • 11456: AF099082
      Homo sapiens xenotropic and polytropic murine retrovirus receptor (XPR1) mRNA,
      complete cds
      gi|4176765|gb|AF099082.1|AF099082[4176765]
    • 11501: AF089744
      Homo sapiens xenotropic and polytropic murine leukemia virus receptor (X3) mRNA,
      complete cds
      gi|4154282|gb|AF089744.1|AF089744[4154282]
    • 11502: AF001095
      Homo sapiens receptor for advanced glycation end products (RAGE) gene, promoter
      region and exon 1
      gi|3093415|gb|AF001095.1|AF001095[3093415]
    • 11503: AF101784
      Homo sapiens b-TRCP variant E3RS-IkappaB mRNA, partial cds
      gi|4165135|gb|AF101784.1|AF101784[4165135]
    • 11504: AF080586
      Homo sapiens galanin receptor type 2 (GALR2) mRNA, complete cds
      gi|4165080|gb|AF080586.1|AF080586[4165080]
    • 11505: U71374
      Homo sapiens HsPex13p mRNA, complete cds
      gi|3738269|gb|U71374.1|HSU71374[3738269]
    • 11506: AF111116
      Homo sapiens silencer of death domains (SODD) mRNA, complete cds
      gi|4160013|gb|AF111116.1|AF111116[4160013]
    • 11507: AF110314
      Homo sapiens herpesvirus immunoglobulin-like receptor HIgR mRNA, complete cds
      gi|4154345|gb|AF110314.1|AF110314[4154345]
    • 11518: AF069543
      Homo sapiens IL-3/IL-5/GM-CSFR receptor beta chain promoter and exon 1 sequence
      gi|4071316|gb|AF069543.1|AF069543[4071316]
    • 11519: U81262
      Homo sapiens LERK5 (LERK5) mRNA, complete cds
      gi|1809333|gb|U81262.1|HSU81262[1809333]
    • 11520: AF097358
      Homo sapiens mast cell function-associated antigen homolog (MAFA) mRNA, complete
      cds
      gi|4139191|gb|AF097358.1|AF097358[4139191]
    • 11521: AF029761
      Homo sapiens decoy receptor 2 mRNA, complete cds
      gi|4106963|gb|AF029761.1|AF029761[4106963]
    • 11522: AF074483
      Homo sapiens GABA-B receptor 2 mRNA, complete cds
      gi|4107511|gb|AF074483.1|AF074483[4107511]
    • 11523: AC006293
      Homo sapiens chromosome 19, cosmid F15658, complete sequence
      gi|4106979|gb|AC006293.1|AC006293[4106979]
    • 11524: AF104419
      Homo sapiens decoy receptor 3 (DcR3) mRNA, complete cds
      gi|4106877|gb|AF104419.1|AF104419[4106877]
    • 11525: AF046059
      Homo sapiens cytokine receptor related protein 4 (CYTOR4) mRNA, complete cds
      gi|4105471|gb|AF046059.1|AF046059[4105471]
    • 11526: AF041262
      Homo sapiens immunoglobulin-like transcript 8 mRNA, complete cds
      gi|4104892|gb|AF041262.1|AF041262[4104892]
    • 11527: AF041261
      Homo sapiens immunoglobulin-like transcript 7 mRNA, complete cds
      gi|4104890|gb|AF041261.1|AF041261[4104890]
    • 11528: AH007196
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 6
      gi|4104446|gb|AH007196.1|SEG_HSTGFRBI[4104446]
    • 11529: AF035670
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 9, and
      complete cds
      gi|4104445|gb|AF035670.1|HSTGFRBI9[4104445]
    • 11530: AF035669
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 8
      gi|4104444|gb|AF035669.1|HSTGFRBI8[4104444]
    • 11531: AF035668
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 7
      gi|4104443|gb|AF035668.1|HSTGFRBI7[4104443]
    • 11532: AF035667
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 6
      gi|4104442|gb|AF035667.1|HSTGFRBI6[4104442]
    • 11533: AF035666
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 5
      gi|4104441|gb|AF035666.1|HSTGFRBI5[4104441]
    • 11534: AF035665
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 4
      gi|4104440|gb|AF035665.1|HSTGFRBI4[4104440]
    • 11535: AF035664
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 3
      gi|4104439|gb|AF035664.1|HSTGFRBI3[4104439]
    • 11536: AF035663
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 2
      gi|4104438|gb|AF035663.1|HSTGFRBI2[4104438]
    • 11537: AF035662
      Homo sapiens transforming growth factor-beta type I receptor gene, exon 1
      gi|4104437|gb|AF035662.1|HSTGFRBI1[4104437]
    • 11538: AF037332
      Homo sapiens Eph-like receptor tyrosine kinase hEphB1b (EphB1) mRNA, complete cds
      gi|4104412|gb|AF037332.1|AF037332[4104412]
    • 11539: AF037331
      Homo sapiens Eph-like receptor tyrosine kinase hEphB1 (EphB1) mRNA, complete cds
      gi|4104410|gb|AF037331.1|AF037331[4104410]
    • 11543: AH007119
      Homo sapiens killer cell inhibitory receptor KIRC1 gene, complete cds
      gi|3776473|gb|AH007119.1|SEG_HSKIRCI[3776473]
    • 11544: AF072410
      Homo sapiens killer cell inhibitory receptor KIRC1 gene, exons 6, 7 and 8 and complete cds
      gi|3776472|gb|AF072410.1|HSKIRCI4[3776472]
    • 11545: AF072409
      Homo sapiens killer cell inhibitory receptor KIRCI gene, exon 5
      gi|3776471|gb|AF072409.1|HSKIRCI3[3776471]
    • 11546: AF072408
      Homo sapiens killer cell inhibitor receptor KIRCI gene, exons 2, 3, and 4
      gi|3776470|gb|AF072408.1|HSKIRCI2[3776470]
    • 11547: AF072407
      Homo sapiens killer cell inhibitory receptor KIRCI gene, exon 1
      gi|3776469|gb|AF072407.1|HSKIRCI1[3776469]
    • 11548: AH007118
      Homo sapiens immunoglobulin-like transcript 10 protein gene, complete cds
      gi|3776467|gb|AH007118.1|SEG_HSILTX[3776467]
    • 11549: AF072101
      Homo sapiens immunoglobulin-like transcript 10 protein gene, exons 7 and 8
      and
      complete cds
      gi|3776466|gb|AF072101.1|HSILTX2[3776466]
    • 11550: AF072100
      Homo sapiens immunoglobulin-like transcript 10 protein gene, exons 1 through
      gi|3776465|gb|AF072100.1|HSILTX1[3776465]
    • 11551: AF072099
      Homo sapiens immunoglobulin-like transcript 3 protein variant 1 gene, complete
      cds
      gi|3776463|gb|AF072099.1|AF072099[3776463]
    • 11553: AF106941
      Homo sapiens beta-arrestin 2 mRNA, complete cds
      gi|4092782|gb|AF106941.1|AF106941[4092782]
    • 11554: AF104304
      Homo sapiens Smad anchor for receptor activation (SARA) mRNA, complete cds
      gi|4092766|gb|AF104304.1|AF104304[4092766]
    • 11555: AF034780
      Homo sapiens lysosphingolipid receptor Edg5 mRNA, complete cds
      gi|4090955|gb|AF034780.1|AF034780[4090955]
    • 11556: AF109401
      Homo sapiens neurotrophic factor artemin precursor (ARTN) mRNA, complete cds
      gi|4071352|gb|AF109401.1|AF109401[4071352]
    • 11557: AF099148
      Homo sapiens GABA-B1a receptor mRNA, complete cds
      gi|4063891|gb|AF099148.1|AF099148[4063891]
    • 11558: AF095448
      Homo sapiens putative G protein-coupled receptor (RAIG1) mRNA, complete cds
      gi|4063889|gb|AF095448.1|AF095448[4063889]
    • 11559: L34689
      Homo sapiens somatostatin receptor isoform 2 (SSTR2) gene, partial cds
      gi|598233|gb|L34689.1|HUMSOREC2X[598233]
    • 11560: AF100161
      Homo sapiens folate receptor type gamma′ gene, partial cds
      gi|4063392|gb|AF100161.1|AF100161[4063392]
    • 11561: AF082076
      Homo sapiens luteinizing hormone receptor (LHR) gene, partial cds
      gi|4063365|gb|AF082076.1|AF082076[4063365]
    • 11562: AC006132
      Homo sapiens chromosome 19, cosmid R28204, complete sequence
      gi|3970930|gb|AC006132.1|AC006132[3970930]
    • 11563: AH007081
      Homo sapiens lectin-type oxidized LDL receptor (OLR1) gene, complete cds
      gi|4050003|gb|AH007081.1|SEG_HSOLR[4050003]
    • 11564: AF079167
      Homo sapiens lectin-type oxidized LDL receptor (OLR1) gene, exons 4, 5, and 6, and complete cds
      gi|4050002|gb|AF079167.1|HSOLR4[4050002]
    • 11565: AF079166
      Homo sapiens lectin-type oxidized LDL receptor (OLR1) gene, exon 3
      gi|4050001|gb|AF079166.1|HSOLR3[4050001]
    • 11566: AF079165
      Homo sapiens lectin-type oxidized LDL receptor (OLR1) gene, exon 2
      gi|4050000|gb|AF079165.1|HSOLR2[4050000]
    • 11567: AF079164
      Homo sapiens lectin-type oxidized LDL receptor (OLR1) gene, exon 1
      gi|4049999|gb|AF079164.1|HSOLR1[4049999]
    • 11568: AF099083
      Homo sapiens growth hormone secretagogue receptor gene, 5′ flanking region and
      partial cds
      gi|4039145|gb|AF099083.1|AF099083[4039145]
    • 11569: AF058390
      Homo sapiens neurotrophin 3 receptor truncated isoform (NTRK3) mRNA, partial cds
      gi|4027932|gb|AF058390.1|AF058390[4027932]
    • 11570: AF058389
      Homo sapiens neurotrophin 3 receptor (NTRK3) mRNA, partial cds
      gi|4027930|gb|AF058389.1|AF058389[4027930]
    • 11877: AF029839
      Homo sapiens alpha 7 neuronal nicotinic receptor mRNA sequence
      gi|3757794|gb|AF029839.1|AF029839[3757794]
    • 11878: AF029838
      Homo sapiens alpha 7 neuronal nicotinic receptor mRNA sequence
      gi|3757793|gb|AF029838.1|AF029838[3757793]
    • 11880: AH007062
      Homo sapiens galanin receptor (GALNR), complete cds
      gi|3064074|gb|AH007062.1|SEG_HSGALNRS[3064074]
    • 11881: U90660
      Homo sapiens galanin receptor (GALNR) gene, exon 3 and complete cds
      gi|3064073|gb|U90660.1|HSGALNRS3[3064073]
    • 11882: U90659
      Homo sapiens galanin receptor (GALNR) gene, exon 2
      gi|3064072|gb|U90659.1|HSGALNRS2[3064072]
    • 11883: U90658
      Homo sapiens galanin receptor (GALNR) gene, exon 1
      gi|3064071|gb|U90658.1|HSGALNRS1[3064071]
    • 11884: AF041474
      Homo sapiens BAF53a (BAF53a) mRNA, complete cds
      gi|4001802|gb|AF041474.1|AF041474[4001802]
    • 11886: AF097942
      Homo sapiens monocyte antigen CD14 precursor (CD14) mRNA, complete cds
      gi|3983126|gb|AF097942.1|AF097942[3983126]
    • 11887: AH007044
      Homo sapiens growth factor receptor (GRB10) gene, alternative splice products,
      complete cds
      gi|3982774|gb|AH007044.1|SEG_HSGRB[3982774]
    • 11904: AF084941
      Homo sapiens pre-T cell receptor alpha chain 1 precursor, gene, complete cds
      gi|3978459|gb|AF084941.1|AF084941[3978459]
    • 11905: AH007043
      Homo sapiens interleukin-7 receptor precursor (IL7R), complete cds
      gi|3978161|gb|AH007043.1|SEG_HSIL7R[3978161]
    • 11906: AF043129
      Homo sapiens interleukin-7 receptor precursor (IL7R) gene, exons 7 and 8 and complete cds
      gi|3978160|gb|AF043129.1|HSIL7R7[3978160]
    • 11907: AF043128
      Homo sapiens interleukin-7 receptor precursor (IL7R) gene, exon 6
      gi|3978159|gb|AF043128.1|HSIL7R6[3978159]
    • 11908: AF043127
      Homo sapiens interleukin-7 receptor precursor (IL7R) gene, exon 5
      gi|3978158|gb|AF043127.1|HSIL7R5[3978158]
    • 11909: AF043126
      Homo sapiens interleukin-7 receptor precursor (IL7R) gene, exon 4
      gi|3978157|gb|AF043126.1|HSIL7R4[3978157]
    • 11910: AF043125
      Homo sapiens interleukin-7 receptor precursor (IL7R) gene, exon 3
      gi|3978156|gb|AF043125.1|HSIL7R3[3978156]
    • 11911: AF043124
      Homo sapiens interleukin-7 receptor precursor (IL7R) gene, exon 2
      gi|3978155|gb|AF043124.1|HSIL7R2[3978155]
    • 11912: AF043123
      Homo sapiens interleukin-7 receptor precursor (IL7R) gene, exon 1
      gi|3978154|gb|AF043123.1|HSIL7R1[3978154]
    • 11913: AH007033
      Homo sapiens prostanoid FP receptor (PTGFR), partial cds
      gi|3941539|gb|AH007033.1|SEG_HSPTF2AGR[3941539]
    • 11914: AF068679
      Homo sapiens prostanoid FF receptor gene, exon and partial cds
      gi|3941538|gb|AF068679.1|HSPTF2AGR4[3941538]
    • 11915: AF068678
      Homo sapiens prostanoid FP receptor (PTGFR) gene, exon
      gi|3941537|gb|AF068678.1|HSPTF2AGR3[3941537]
    • 11916: AF068677
      Homo sapiens prostanoid FP receptor (PTGFR) gene, exon and partial 5′UTR
      gi|3941536|gb|AF068677.1|HSPTF2AGR2[3941536]
    • 11917: AF068676
      Homo sapiens prostanoid FP receptor (PTGFR) gene, exon
      gi|3941535|gb|AF068676.1|HSPTF2AGR1[3941535]
    • 11918: AF035776
      Homo sapiens oxidized low-density lipoprotein receptor mRNA, complete cds
      gi|3941299|gb|AF035776.1|AF035776[3941299]
    • 11920: AF091501
      Homo sapiens receptor protein patched 2 (PTCH2) mRNA, complete cds
      gi|3929234|gb|AF091501.1|AF091501[3929234]
    • 11953: X98174
      H. sapiens mRNA for MACH-alpha-3 protein
      gi|3928273|emb|X98174.1|HSMACHA3[3928273]
    • 11955: X68990
      Homo sapiens CR2 mRNA for complement receptor
      gi|3928195|emb|X68990.1|HSCR2AA[3928195]
    • 11956: X63128
      H. sapiens mRNA for activin receptor
      gi|3928172|emb|X63128.1|HSACTREC[3928172]
    • 11958: AF074397
      Homo sapiens anti-mullerian hormone type II receptor (AMHR2) gene, promoter region and partial cds
      gi|3916231|gb|AF074397.1|AF074397[3916231]
    • 11959: U72648
      Homo sapiens alpha2-C4-adrenergic receptor gene, complete cds
      gi|3914602|gb|U72648.1|HSU72648[3914602]
    • 11960: Y10148
      H. sapiens mRNA for NTR2 receptor
      gi|3901027|emb|Y10148.1|HSNTR2REC[3901027]
    • 11961: Y12476
      Homo sapiens putative GPR37 gene (exon 1 and joined CDS)
      gi|2570029|emb|Y12476.1|HSY12476[2570029]
    • 11962: AJ000479
      Homo sapiens mRNA for putative G-protein coupled receptor, EDG6
      gi|3805931|emb|AJ000479.1|HSEDG4[3805931]
    • 11963: Y12477
      Homo sapiens putative GPR37 gene, exon 2
      gi|2570031|emb|Y12477.1|HSY12477[2570031]
    • 11964: X04329
      Homo sapiens mRNA fragment for receptor-like furin
      gi|31479|emb|X04329.1|HSFUR1[31479]
    • 11965: AH007002
      Homo sapiens chromosome 1 map 1q12-q13
      gi|3892221|gb|AH007002.1|SEG_HSM1MUSR[3892221]
    • 11966: AF091493
      Homo sapiens M1 muscarinic receptor gene, exons 2 and 3
      gi|3892220|gb|AF091493.1|HSM1MUSR2[3892220]
    • 11967: AF091492
      Homo sapiens M1 muscarinic receptor gene, promoter region and exon 1
      gi|3892219|gb|AF091492.1|HSM1MUSR1[3892219]
    • 12129: AF077820
      Homo sapiens LDL receptor member LR3 mRNA, complete cds
      gi|3831747|gb|AF077820.1|AF077820[3831747]
    • 12130: AF055992
      Homo sapiens Duffy antigen/chemokine receptor (FY) gene, FY*X allele,
      complete cds
      gi|3659623|gb|AF055992.1|AF055992[3659623]
    • 12131: U58675
      Homo sapiens Chromosome 17 p13 Cosmid Clone cos39, complete sequence
      gi|3849817|gb|U58675.1|U58675[3849817]
    • 12132: AF077346
      Homo sapiens interleukin-18 receptor accessory protein-like mRNA, complete cds
      gi|3851059|gb|AF077346.1|AF077346[3851059]
    • 12136: Z17227
      Homo sapiens mRNA for transmebrane receptor protein
      gi|393378|emb|Z17227.1|HSTRECP[393378]
    • 12137: AF082742
      Homo sapiens CC chemokine receptor 5 (CCR5) gene, promoter region and partial sequence
      gi|3561057|gb|AF082742.1|AF082742[3561057]
    • 12139: Z34897
      H. sapiens mRNA for H1 histamine receptor
      gi|510295|emb|Z34897.1|HSHISTR1[510295]
    • 12140: X76786
      H. sapiens histamine H1 receptor gene
      gi|442517|emb|X76786.1|HSHISH1[442517]
    • 12141: AC005933
      Homo sapiens chromosome 19, cosmid F15472, complete sequence
      gi|3845348|gb|AC005933.1|AC005933[3845348]
    • 12142: AF094755
      Homo sapiens glycine receptor beta subunit precursor (GLRB), variant B mRNA, complete cds
      gi|3834636|gb|AF094755.1|AF094755[3834636]
    • 12143: AF094754
      Homo sapiens glycine receptor beta subunit precursor (GLRB), variant A mRNA, complete cds
      gi|3834634|gb|AF094754.1|AF094754[3834634]
    • 12144: AF091512
      Homo sapiens familial Mediterranean fever locus genomic sequence
      gi|3834584|gb|AF091512.1|AF091512[3834584]
    • 12145: AF065876
      Homo sapiens olfactory receptor (OR2D2) gene, partial cds
      gi|3831618|gb|AF065876.1|AF065876[3831618]
    • 12147: AF065874
      Homo sapiens olfactory receptor (OR10A1) gene, partial cds
      gi|3831615|gb|AF065874.1|AF065874[3831615]
    • 12151: AF065870
      Homo sapiens olfactory receptor (OR6A1) gene, complete cds
      gi|38316100gb|AF065870.1|AF065870[3831610]
    • 12158: AF065863
      Homo sapiens olfactory receptor (OR5F1) gene, partial cds
      gi|3831602|gb|AF065863.1|AF065863[3831602]
    • 12160: AF065861
      Homo sapiens olfactory receptor (OR5D4) gene, partial cds
      gi|3831599|gb|AF065861.1|AF06S861[3831599]
    • 12161: AF065860
      Homo sapiens olfactory receptor (OR5D3) gene, partial cds
      gi|3831597|gb|AF065860.1|AF065860[3831597]
    • 12170: AH006968
      Homo sapiens
      gi|2828129|gb|AH006968.1|SEG_HSCRFR[2828129]
    • 12171: AF039523
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 14 and complete cds
      gi|2828128|gb|AF039523.1|HSCRFR14[2828128]
    • 12172: AF039522
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 13
      gi|2828127|gb|AF039522.1|HSCRFR13[2828127]
    • 12173: AF039521
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 12
      gi|2828126|gb|AF039521.1|HSCRFR12[2828126]
    • 12174: AF039520
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 11
      gi|2828125|gb|AF039520.1|HSCRFR11[2828125]
    • 12175: AF039519
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 10
      gi|2828124|gb|AF039519.1|HSCRFR10[2828124]
    • 12176: AF039518
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 9
      gi|2828123|gb|AF039518.1|HSCRFR09[2828123]
    • 12177: AF039517
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 8
      gi|2828122|gb|AF039517.1|HSCRFR08[2828122]
    • 12178: AF039516
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 7
      gi|2828121|gb|AF039516.1|HSCRFR07[2828121]
    • 12179: AF039515
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 6
      gi|28281201gb|AF039515.1|HSCRFR06[2828120]
    • 12180: AF039514
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 5
      gi|2828119|gb|AF039514.1|HSCRFR05[2828119]
    • 12181: AF039513
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 4
      gi|2828118|gb|AF039513.1|HSCRFR04[2828118]
    • 12182: AF039512
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 3
      gi|2828117|gb|AF039512.1|HSCRFR03[2828117]
    • 12183: AF039511
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 2
      gi|2828116|gb|AF039511.1|HSCRFR02[2828116]
    • 12184: AF039510
      Homo sapiens corticotropin-releasing factor type 1 receptor gene, exon 1
      gi|2828115|gb|AF039510.1|HSCRFR01[2828115]
    • 12185: AF030186
      Homo sapiens glypican-4 (GPC4) mRNA, complete cds
      gi|3831546|gb|AF030186.1|AF030186[3831546]
    • 12206: AJ006353
      Homo sapiens mRNA for ephrin-A4 protein, soluble form
      gi|3821236|emb|AJ006353.1|HSA6353[3821236]
    • 12212: AF055634
      Homo sapiens transmembrane receptor UNC5C (UNC5C) mRNA, complete cds
      gi|3789764|gb|AF055634.1|AF055634[3789764]
    • 12227: AH006936
      Homo sapiens activin receptor type IIB (ACVR2B), complete cds
      gi|3769442|gb|AH006936.1|SEG_HSACVR2B[3769442]
    • 12228: AF060202
      Homo sapiens activin receptor type IIB (ACVR2B) gene, exon 11 and complete cds
      gi|3769441|gb|AF060202.1|HSACVR2B4[3769441]
    • 12229: AF060201
      Homo sapiens activin receptor type IIB (ACVR2B) gene, exons 8, 9, and 10
      gi|3769440|gb|AF060201.1|HSACVR2B3[3769440]
    • 12230: AF060200
      Homo sapiens activin receptor type IIB (ACVR2B) gene, exons 2 through 7
      gi|3769439|gb|AF060200.1|HSACVR2B2[3769439]
    • 12231: AF060199
      Homo sapiens activin receptor type IIB (ACVR2B) gene, exon 1
      gi|3769438|gb|AF060199.1|HSACVR2B[3769438]
    • 12232: AF037646
      Homo sapiens alpha-7 neuronal nicotinic acetylcholine receptor precursor RNA, partial sequence
      gi|3757808|gb|AF037646.1|AF037646[3757808]
    • 12233: AF036903
      Homo sapiens alpha-7 neuronal nicotinic acetylcholine receptor mRNA, alternatively spliced, partial sequence
      gi|3757807|gb|AF036903.1|AF036903[3757807]
    • 12234: AH006931
      Homo sapiens lipoprotein receptor-related protein (LRP1) gene, complete cds
      gi|3493575|gb|AH006931.1|SEG_HSLRPSS[3493575]
    • 12235: AF058427
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 80 through 89 and complete cds
      gi|3493574|gb|AF058427.1|HSLRPSS61[3493574]
    • 12236: AF058426
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 78 and 79
      gi|3493573|gb|AF058426.1|HSLRPSS59[3493573]
    • 12237: AF058425
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 77
      gi|3493572|gb|AF058425.1|HSLRPSS57[3493572]
    • 12238: AF058424
  • Homo sapiens lipoprotein receptor-related protein (LRP1), exon 76
  • gi|3493571|gb|AF058424.1|HSLRPSS55[3493571]
    • 12239: AF058423
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 71 through 75
      gi|3493570|gb|AF058423.1|HSLRPSS53[3493570]
    • 12240: AF058422
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 61 through 70
      gi|3493569|gb|AF058422.1|HSLRPSS51[3493569]
    • 12241: AF058421
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 59 and 60
      gi|3493568|gb|AF058421.1|HSLRPSS49[3493568]
    • 12242: AF058420
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 56, 57, and
      gi|3493567|gb|AF058420.1|HSLRPSS47[3493567]
    • 12243: AF058419
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 45 through 55
      gi|3493566|gb|AF058419.1|HSLRPSS45[3493566]
    • 12244: AF058418
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 43 and 44
      gi|3493565|gb|AF058418.1|HSLRPSS43[3493565]
    • 12245: AF058417
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 42
      gi|3493564|gb|AF058417.1|HSLRPSS41[3493564]
    • 12246: AF058416
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 39, 40, and
      gi|3493563|gb|AF058416.1|HSLRPSS39[3493563]
    • 12247: AF058415
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 36, 37, and
      gi|3493562|gb|AF058415.1|HSLRPSS37[3493562]
    • 12248: AF058414
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 27 through 34
      gi|3493561|gb|AF058414.1|HSLRPSS35[3493561]
    • 12249: AF058413
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 25 and 26
      gi|3493560|gb|AF058413.1|HSLRPSS33[3493560]
    • 12250: AF058412
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 23 and 24
      gi|3493559|gb|AF058412.1|HSLRPSS31[3493559]
    • 12251: AF058411
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 21 and 22
      gi|3493558|gb|AF058411.1|HSLRPSS29[3493558]
    • 12252: AF058410
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 20
      gi|3493557|gb|AF058410.1|HSLRPSS27[3493557]
    • 12253: AF058409
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 18 and 19
      gi|3493556|gb|AF058409.1|HSLRPSS25[3493556]
    • 12254: AF058408
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 16 and 17
      gi|3493555|gb|AF058408.1|HSLRPSS23[3493555]
    • 12255: AF058407
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 14 and 15
      gi|3493554|gb|AF058407.1|HSLRPSS21[3493554]
    • 12256: AF058406
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 13
      gi|3493553|gb|AF058406.1|HSLRPSS19[3493553]
    • 12257: AF058405
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 12
      gi|3493552|gb|AF058405.1|HSLRPSS17[3493552]
    • 12258: AF058404
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 11
      gi|3493551|gb|AF058404.1|HSLRPSS15[3493551]
    • 12259: AF058403
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 9 and 10
      gi|3493550|gb|AF058403.1|HSLRPSS13[3493550]
    • 12260: AF058402
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 7 and 8
      gi|493549|gb|AF058402.1|HSLRPSS11[3493549r
    • 12261: AF058401
      Homo sapiens lipoprotein receptor-related protein (LRP1), exons 5 and 6
      gi|3493548|gb|AF058401.1|HSLRPSS09[3493548]
    • 12262: AF058400
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 4
      gi|3493547|gb|AF058400.1|HSLRPSS07[3493547]
    • 12263: AF058399
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 3
      gi|3493546|gb|AF058399.1|HSLRPSS05[3493546]
    • 12264: AF058398
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 2
      gi|3493545|gb|AF058398.1|HSLRPSS03[3493545]
    • 12265: AF058397
      Homo sapiens lipoprotein receptor-related protein (LRP1), exon 1
      gi|3493544|gb|AF058397.1|HSLRPSS01[3493544]
    • 12267: Y11044
      Homo sapiens mRNA for GABA-BR1a (hGB1a) receptor
      gi|2826760|emb|Y11044.1|HSGTHLA1[2826760]
    • 12277: AF073019
      Homo sapiens clone 21 T cell signal transduction molecule SAP mRNA, complete cds
      gi|3695070|gb|AF073019.1|AF073019[3695070]
    • 12278: AF072930
      Homo sapiens clone 14 T cell signal transduction molecule SAP mRNA, complete cds
      gi|3695068|gb|AF072930.1|AF072930[3695068]
    • 12279: Y12670
      Homo sapiens mRNA for leptin receptor gene-related protein
      gi|2266637|emb|Y12670.1|HSOBRGRP[2266637]
    • 12280: AF091890
      Homo sapiens G-protein coupled receptor RE2 mRNA, complete cds
      gi|3659902|gb|AF091890.1|AF091890[3659902]
    • 12281: Y09586
      Homo sapiens mRNA for serotonin 4 receptor (h5-HT4(a)), splice variant
      gi|2584764|emb|Y09586.1|HS5HT4SAR[2584764]
    • 12282: X77777
      H. sapiens intestinal VIP receptor related protein mRNA
      gi|456352|emb|X77777.1|HSVIPRRP[456352]
    • 12283: AJ001383
      Homo sapiens activating NK-receptor (NK-p46) mRNA
      gi|3647278|emb|AJ001383.1|HSJ001383[3647278]
    • 12284: AJ224901
      Homo sapiens mRNA for ZNF198 protein
      gi|3647276|emb|AJ224901.1|HSAJ4901[3647276]
    • 12285: AJ006123
      Homo sapiens mRNA for NK receptor (NKp46), isoform d
      gi|3647272|emb|AJ006123.1|HSA6123[3647272]
    • 12286: AJ006122
      Homo sapiens mRNA for NK receptor (NKp46) isoform c
      gi|3647270|emb|AJ006122.1|HSA6122[3647270]
    • 12287: AJ006121
      Homo sapiens mRNA for NK receptor (NKp46), isoform b
      gi|3647268|emb|AJ006121.1|HSA6121[3647268]
    • 12289: X99906
      Homo sapiens mRNA for alpha endosulfine
      gi|2764973|emb|X99906.1|HSALPEND[2764973]
    • 12292: U52064
      Kaposi's sarcoma-associated herpes-like virus ORF73 homolog gene, complete cds
      gi|1633571|gb|U52064.1|KSU52064[1633571]
    • 12293: U29343
      Homo sapiens hyaluronan receptor (RHAMM) mRNA, complete cds
      gi|2959555|gb|U29343.1|HSU29343[2959555]
    • 12294: AF035771
      Homo sapiens Na+/H+ exchanger regulatory factor 2 (NHERF-2) mRNA, complete cds
      gi|2665825|gb|AF035771.1|AF035771[2665825]
    • 12296: AF023849
      Homo sapiens TNF receptor-related receptor for TRAIL mRNA, complete cds
      gi|2653844|gb|AF023849.1|AF023849[2653844]
    • 12297: AH006710
      Homo sapiens interferon-gamma receptor alpha chain (interferon-gamma receptor alpha chain gene), complete cds
      gi|2078444|gb|AH006710.1|SEG_HSINFGRA[2078444]
    • 12298: U19247
      Homo sapiens interferon-gamma receptor alpha chain gene, exon 7 and complete cds
      gi|632541|gb|U19247.1|HSINFGRA7[632541]
    • 12299: U19246
      Homo sapiens interferon-gamma receptor alpha chain gene, exon 6
      gi|632540|gb|U19246.1|HSINFGRA6[632540]
    • 12300: U19245
      Homo sapiens interferon-gamma receptor alpha chain gene, exon 5
      gi|632539|gb|U19245.1|HSINFGRA5[632539]
    • 12301: U19244
      Homo sapiens interferon-gamma receptor alpha chain gene, exon 4
      gi|632538|gb|U19244.1|HSINFGRA4[632538]
    • 12302: U19243
      Homo sapiens interferon-gamma receptor alpha chain gene, exon 3
      gi|632537|gb|U19243.1|HSINFGRA3[632537]
    • 12303: U19242
      Homo sapiens interferon-gamma receptor alpha chain gene, exon 2
      gi|632536|gb|U19242.1|HSINFGRA2[632536]
    • 12304: U19241
      Homo sapiens interferon-gamma receptor alpha chain gene, exon 1
      gi|632535|gb|U19241.1|HSINFGRA1[632535]
    • 12305: AF027957
      Homo sapiens G protein-coupled receptor (GPR35) gene, complete cds
      gi|2739108|gb|AF027957.1|AF027957[2739108]
    • 12306: AF027956
      Homo sapiens G protein-coupled receptor (GPR30) gene, complete cds
      gi|2739106|gb|AF027956.1|AF027956[2739106]
    • 12307: AF016709
      Homo sapiens ATP receptor subunit (P2X5) mRNA, complete cds
      gi|2731560|gb|AF016709.1|AF016709[2731560]
    • 12308: AF035824
      Homo sapiens vesicle soluble NSF attachment protein receptor (VTI1) mRNA, complete cds
      gi|2687399|gb|AF035824.1|AF035824[2687399]
    • 12309: U96845
      Homo sapiens natual killer cell group 2-F (NKG2-F) mRNA, complete cds
      gi|2673988|gb|U96845.1|HSU96845[2673988]
    • 12310: AF022139
      Homo sapiens lysosphingolipid receptor (EDG3) mRNA, partial cds
      gi|2668611|gb|AF022139.1|AF022139[2668611]
    • 12311: AF022137
      Homo sapiens G protein-coupled receptor (EDG1) mRNA, partial cds
      gi|2668607|gb|AF022137.1|AF022137[2668607]
    • 12312: AF031556
      Homo sapiens clone 17.30 immunoglobulin-like transcript 5 mRNA, complete cds
      gi|2665646|gb|AF031556.1|AF031556[2665646]
    • 12313: AF031555
      Homo sapiens clone 17.23 immunoglobulin-like transcript 5 mRNA, complete cds
      gi|2665644|gb|AF031555.1|AF031555[2665644]
    • 12314: AF031554
      Homo sapiens clone 17.18 immunoglobulin-like transcript 5 mRNA, complete cds
      gi|2665642|gb|AF031554.1|AF031554[2665642]
    • 12315: AF031553
      Homo sapiens clone DC.1 immunoglobulin-like transcript 5 mRNA, complete cds
      gi|2665640|gb|AF031553.1|AF031553[2665640]
    • 12316: AF009644
      Homo sapiens clone 41 immunoglobulin-like transcript 5 protein mRNA, complete cds
      gi|2662447|gb|AF009644.1|AF009644[2662447]
    • 12317: AF009643
      Homo sapiens clone 6 immunoglobulin-like transcript 5 protein mRNA, complete cds
      gi|2662445|gb|AF009643.1|AF009643[2662445]
    • 12318: AF009642
      Homo sapiens clone 40 immunoglobulin-like transcript 5 protein mRNA, complete cds
      gi|2662443|gb|AF009642.1|AF009642[2662443]
    • 12319: AF009641
      Homo sapiens clone 36 immunoglobulin-like transcript 5 protein mRNA, complete cds
      gi|2662441|gb|AF009641.1|AF009641[2662441]
    • 12320: AF009640
      Homo sapiens clone 33 immunoglobulin-like transcript 5 protein mRNA, complete cds
      gi|2662439|gb|AF009640.1|AF009640[2662439]
    • 12321: AF009639
      Homo sapiens clone 31 immunoglobulin-like transcript 5 protein mRNA, complete cds
      gi|2662437|gb|AF009639.1|AF009639[2662437]
    • 12322: AF009638
      Homo sapiens clone 22 immunoglobulin-like transcript 5 protein mRNA, complete cds
      gi|2662435|gb|AF009638.1|AF009638[2662435]
    • 12323: AF009637
      Homo sapiens clone 19 immunoglobulin-like transcript 5 protein mRNA, complete cds
      gi|2662433|gb|AF009637.1|AF009637[2662433]
    • 12324: AF009636
      Homo sapiens clone 17.8 immunoglobulin-like transcript 5 protein mRNA, complete
      cds
      gi|2662431|gb|AF009636.1|AF009636[2662431]
    • 12325: AF009635
      Homo sapiens clone 17.7 immunoglobulin-like transcript 5 protein mRNA, complete
      cds
      gi|2662429|gb|AF009635.1|AF009635[2662429]
    • 12326: AF009634
      Homo sapiens clone 17.6 immunoglobulin-like transcript 5 protein mRNA, complete
      cds
      gi|2662427|gb|AF009634.1|AF009634[2662427]
    • 12327: AF009633
      Homo sapiens clone 17.11 immunoglobulin-like transcript 5 protein mRNA, complete
      cds
      gi|2662425|gb|AF009633.1|AF009633[2662425]
    • 12328: AF009632
      Homo sapiens clone 17.10 immunoglobulin-like transcript 5 protein mRNA, complete
      cds
      gi|2662423|gb|AF009632.1|AF009632[2662423]
    • 12329: AF014924
      Homo sapiens immunoglobulin-like transcript 6a (ILT6a) mRNA, complete cds
      gi|2661224|gb|AF014924.1|AF014924[2661224]
    • 12330: AF014923
      Homo sapiens immunoglobulin-like transcript 6 (ILT6) mRNA, complete cds
      gi|2661222|gb|AF014923.1|AF014923[2661222]
    • 12331: AF011566
      Homo sapiens clone 17 immunoglobulin-like transcript 4 mRNA, complete cds
      gi|2660709|gb|AF011566.1|AF011566[2660709]
    • 12332: AF011565
      Homo sapiens clone 26 immunoglobulin-like transcript 4 mRNA, complete cds
      gi|2660707|gb|AF011565.1|AF011565[2660707]
    • 12333: AF009007
      Homo sapiens immunoglobulin-like transcript 2c mRNA, complete cds
      gi|2660705|gb|AF009007.1|AF009007[2660705]
    • 12334: AF009006
      Homo sapiens immunoglobulin-like transcript 2b mRNA, complete cds
      gi|2660703|gb|AF009006.1|AF009006[2660703]
    • 12335: AF009005
      Homo sapiens immunoglobulin-like transcript 2a mRNA, complete cds
      gi|2660701|gb|AF009005.1|AF009005[2660701]
    • 12336: AH006705
      Homo sapiens mu opioid receptor (OPRM1) and mu opioid receptor (OPRM1)s, partial
      cds
      gi|2655104|gb|AH006705.1|SEG_HSOPRMI[2655104]
    • 12338: AF024516
      Homo sapiens mu opioid receptor (OPRM1) gene, partial cds, exons 2 and 3, complete IVS2
      gi|2655102|gb|AF024516.1|HSOPRMI2[2655102]
    • 12339: AF024515
      Homo sapiens mu opioid receptor (OPRM1) gene, partial cds, exon 1
      gi|2655101|gb|AF024515.1|HSOPRMI1[2655101]
    • 12410: AF030625
      Homo sapiens SCCL vasopressin subtype 1a receptor mRNA, complete cds
      gi|2623229|gb|AF030625.1|AF030625[2623229]
    • 12411: AF002986
      Homo sapiens platelet activating receptor homolog (H963) mRNA, complete cds
      gi|2580587|gb|AF002986.1|AF002986[2580587]
    • 12412: AF023614
      Homo sapiens transmembrane activator and CAML interactor (TACI) mRNA, complete
      cds
      gi|2554947|gb|AF023614.1|AF023614[2554947]
    • 12413: AF022860
      Homo sapiens neuropilin-2(a17) mRNA, complete cds
      gi|2547131|gb|AF022860.1|AF022860[2547131]
    • 12414: AF022859
      Homo sapiens neuropilin-2(a0) mRNA, complete cds
      gi|2547129|gb|AF022859.1|AF022859[2547129]
    • 12415: AF016849
      Homo sapiens apoptosis inducing receptor TRAIL-R2 (TRAILR2) mRNA, complete cds
      gi|2465585|gb|AF016849.1|AF016849[2465585]
    • 12416: AF013171
      Homo sapiens TNF-related ligand TRANCE mRNA, partial cds
      gi|2411499|gb|AF013171.1|AF013171[2411499]
    • 12417: AF018956
      Homo sapiens neuropilin mRNA, complete cds
      gi|2407640|gb|AF018956.1|AF018956[2407640]
    • 12419: AF015257
      Homo sapiens flow-induced endothelial G protein-coupled receptor (FEG-1) mRNA,
      complete cds
      gi|2353152|gb|AF015257.1|AF015257[2353152]
    • 12420: U75285
      Homo sapiens apoptosis inhibitor survivin gene, complete cds
      gi|2315862|gb|U75285.1|HSU75285[2315862]
    • 12421: AF012270
      Homo sapiens visual pigment-like receptor peropsin (Rrh) mRNA, complete cds
      gi|2387009|gb|AF012270.1|AF012270[2307009]
    • 12422: AH006692
      Homo sapiens chromosome 19 clone PAC clone 72N6 map 19q13.42
      gi|2290633|gb|AH006692.1|SEG_HSNKAT2A[2290633]
    • 12423: U97180
      Homo sapiens NKAT-2a like protein (KIR) gene, exons 8 and 9 and complete cds
      gi|2290632|gb|U97180.1|HSNKAT2A8[2290632]
    • 12424: U97179
      Homo sapiens NKAT-2a like protein (KIR) gene, exon 7
      gi|2290631|gb|U97179.1|HSNKAT2A7[2290631]
    • 12425: U97178
      Homo sapiens NKAT-2a like protein (KIR) gene, exon 6
      gi|2290630|gb|U97178.1|HSNKAT2A6[2290630]
    • 12426: U97177
      KIR Homo sapiens NKAT-2a like protein (KIR) gene, exon 5
      gi|2290629|gb|U97177.1|HSNKAT2A5[2290629]
    • 12427: U97176
      Homo sapiens NKAT-2a like protein (KIR) gene, exon 4
      gi|2290628|gb|U97176.1|HSNKAT2A4[2290628]
    • 12429: U97174
      KIR Homo sapiens NKAT-2a like protein (KIR) gene, exon 2
      gi|2290626|gb|U97174.1|HSNKAT2A2[2290626]
    • 12430: U97173
      Homo sapiens NKAT-2a like protein (KIR) gene, exon 1
      gi|2290625|gb|U97173.1|HSNKAT2A1[2290625]
    • 12431: U97075
      Homo sapiens FLICE-like inhibitory protein short form mRNA, complete cds
      gi|2253680|gb|U97075.1|U97075[2253680]
    • 12432: U97074
      Homo sapiens FLICE-like inhibitory protein long form mRNA, complete cds
      gi|2253678|gb|U97074.1|U97074[2253678]
    • 12688: L76380
      Homo sapiens (clone HSNME29) CGRP type 1 receptor mRNA, complete cds
      gi|1321593|gb|L76380.1|HUMCGRPB[1321593]
    • 12689: L49241
      Homo sapiens fibroblast growth factor 2 (FGFR2) Ser354Cys mutant gene, exon IIIc
      gi|1129116|gb|L49241.1|HUMFGF354C[1129116]
    • 12690: L49240
      Homo sapiens fibroblast growth factor 2 (FGFR2) Ala344Gly mutant gene, exon IIIc
      gi|1129114|gb|L49240.1|HUMFGF344G[1129114]
    • 12691: L49239
      Homo sapiens fibroblast growth factor 2 (FGFR2) Cys342Tyr mutant gene, exon IIIc
      gi|1129112|gb|L49239.1|HUMFGF342Y[1129112]
    • 12692: L49238
      Homo sapiens fibroblast growth factor 2 (FGFR2) Cys342Ser mutant gene, exon IIIc
      gi|1129110|gb|L49238.1|HUMFGF342S[1129110]
    • 12693: L49242
      Homo sapiens fibroblast growth factor 2 (FGFR2) Gly338Arg mutant gene, exon IIIc
      gi|1129108|gb|L49242.1|HUMFGF338R[1129108]
    • 12694: L49237
      Homo sapiens fibroblast growth factor 2 (FGFR2) Gln289Pro mutant gene, exon IIIu
      gi|1129106|gb|L49237.1|HUMFGF289P[1129106]
    • 12842: L38734
      Homo sapiens hepatoma transmembrane kinase ligand (HTK ligand) mRNA, complete cds
      gi|769675|gb|L38734.1|HUMHTK[769675]
    • 12843: L40764
      Homo sapiens vasoactive intestinal polypeptide receptor 2 (VIPR2) mRNA, complete
      cds
      gi|712836|gb|L40764.1|HUMVIPR2A[712836]
    • 12844: AF068181
      Homo sapiens B cell linker protein BLNK-s mRNA, alternatively spliced, complete
      cds
      gi|3406750|gb|AF068181.1|AF068181[3406750]
    • 12845: AF068180
      Homo sapiens B cell linker protein BLNK mRNA, alternatively spliced, complete cds
      gi|3406748|gb|AF068180.1|AF068180[3406748]
    • 12846: AF064801
      Homo sapiens multiple membrane spanning receptor TRC8 (TRC8) mRNA, complete cds
      gi|3395786|gb|AF064801.1|AF064801[3395786]
    • 12847: AH006513
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene
      gi|3342791|gb|AH006513.1|SEG_HSGLRA3S[3342791]
    • 12848: AF017724
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 10n, and complete cds
      gi|3342790|gb|AF017724.1|HSGLRA3S10[3342790]
    • 12849: AF017723
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 9n
      gi|3342789|gb|AF017723.1|HSGLRA3S09[3342789]
    • 12850: AF017722
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 8
      gi|3342788|gb|AF017722.1|HSGLRA3S08[3342788]
    • 12851: AF017721
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 7
      gi|3342787|gb|AF017721.1|HSGLRA3S07[3342787]
    • 12852: AF017720
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 6
      gi|3342786|gb|AF017720.1|HSGLRA3S06[3342786]
    • 12853: AF017719
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 5
      gi|3342785|gb|AF017719.1|HSGLRA3S05[3342785]
    • 12854: AF017718
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 4
      gi|3342784|gb|AF017718.1|HSGLRA3S04[3342784]
    • 12855: AF017717
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 3
      gi|3342783|gb|AF017717.1|HSGLRA3S03[3342783]
    • 12856: AF017716
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 2
      gi|3342782|gb|AF017716.1|HSGLRA3S02[3342782]
    • 12857: AF017715
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) gene, exon 1
      gi|3342781|gb|AF017715.1|HSGLRA3S01[3342781]
    • 12858: AF018157
      Homo sapiens glycine receptor alpha 3 subunit (GLRA3) mRNA, alternatively spliced, partial cds
      gi|3342237|gb|AF018157.1|AF018157[3342237]
    • 12861: AF045764
      Homo sapiens orphan G protein-coupled receptor (GPR32) gene, complete cds
      gi|3282838|gb|AF045764.1|AF045764[3282838]
    • 12864: AF053004
      Homo sapiens class I cytokine receptor (WSX1) mRNA, complete cds
      gi|31532400gb|AF053004.1|AF053004[3153240]
    • 12865: AF055872
      Homo sapiens Apo3/DR3 ligand (APO3L) mRNA, complete cds
      gi|3108230|gb|AF055872.1|AF055872[3108230]
    • 12866: AF057140
      Homo sapiens cargo selection protein TIP47 (TIP47) mRNA, complete cds
      gi|3095185|gb|AF057140.1|AF057140[3095185]
    • 12870: AF028785
      Homo sapiens phosphatidylinositol 3-kinase p55 gamma regulatory subunit mRNA, complete cds
      gi|3046405|gb|AF028785.1|AF028785[3046405]
    • 12872: AF027826
      Homo sapiens putative seven pass transmembrane protein (TM7SF1) mRNA, complete
      cds
      gi|2992627|gb|AF027826.1|AF027826[2992627]
    • 12883: AF040630
      Homo sapiens galanin receptor GalR2 mRNA, complete cds
      gi|2921759|gb|AF040630.1|AF040630[2921759]
    • 12904: U86281
      Homo sapiens olfactory receptor (OR7-141) gene, partial cds
      gi|2921715|gb|U86281.1|U86281[2921715]
    • 12905: U86280
      Homo sapiens olfactory receptor (OR7-140) gene, partial cds
      gi|2921713|gb|U86280.1|U86280[2921713]
    • 12906: U86279
      Homo sapiens olfactory receptor (OR7-139) gene, partial cds
      gi|2921711|gb|U86279.1|U86279[2921711]
    • 12907: U86278
      Homo sapiens olfactory receptor (OR7-138) gene, partial cds
      gi|2921709|gb|U86278.1|U86278[2921709]
    • 12911: U86274
      Homo sapiens olfactory receptor (OR5-85) gene, partial cds
      gi|2921704|gb|U86274.1|U86274[2921704]
    • 12915: U86270
      Homo sapiens olfactory receptor (OR5-40) gene, partial cds
      gi|2921699|gb|U86270.1|U86270[2921699]
    • 12921: U86264
      Homo sapiens olfactory receptor (OR3-145) gene, partial cds
      gi|2921692|gb|U86264.1|U86264[2921692]
    • 12927: AH006491
      Homo sapiens GPI-linked anchor protein (GFRA1), complete cds
      gi|2921544|gb|AH006491.1|SEG_HSGFRA1G[2921544]
    • 12928: AF038420
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 11 and complete cds
      gi|2921543|gb|AF038420.1|HSGFRA1G11[2921543]
    • 12929: AF038419
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 10
      gi|2921542|gb|AF038419.1|HSGFRA1G1002921542]
    • 12930: AF038418
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 9
      gi|2921541|gb|AF038418.1|HSGFRA1G 9[2921541]
    • 12931: AF038417
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 8
      gi|2921540|gb|AF038417.1|HSGFRA1G 8[2921540]
    • 12932: AF038416
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 7
      gi|2921539|gb|AF038416.1|HSGFRA1G 7[2921539]
    • 12933: AF038415
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 6
      gi|2921538|gb|AF038415.1|HSGFRA1G 6[2921538]
    • 12934: AF038414
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 5
      gi|2921537|gb|AF038414.1|HSGFRA1G 5[2921537]
    • 12935: AF038413
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 4
      gi|2921536|gb|AF038413.1|HSGFRA1G 4[2921536]
    • 12936: AF038412
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 3
      gi|2921535|gb|AF038412.1|HSGFRA1G 3[2921535]
    • 12937: AF038411
      Homo sapiens GPI-linked anchor protein (GFRA1) gene, exon 2
      gi|2921534|gb|AF038411.1|HSGFRA1G 2[2921534]
    • 12938: AF036906
      Homo sapiens linker for activation of T cells (LAT) mRNA, alternatively spliced
      form, complete cds
      gi|2828025|gb|AF036906.1|AF036906[2828025]
    • 12939: AF036905
      Homo sapiens linker for activation of T cells (LAT) mRNA, complete cds
      gi|2828023|gb|AF036905.1|AF036905[2828023]
    • 12940: AF043724
      Homo sapiens hepatitis A virus cellular receptor 1 (hHAVcr-1) mRNA, complete cds
      gi|2827453|gb|AF043724.1|AF043724[2827453]
    • 12954: U86239
      Homo sapiens olfactory receptor (OR16-90) gene, partial cds
      gi|2921659|gb|U86239.1|U86239[2921659]
    • 12955: U86238
      Homo sapiens olfactory receptor (OR16-89) gene, partial cds
      gi|2921657|gb|U86238.1|U86238[2921657]
    • 12956: U86237
      Homo sapiens olfactory receptor (OR16-88) gene, partial cds
      gi|2921655|gb|U86237.1U86237[2921655]
    • 12957: U86236
      Homo sapiens olfactory receptor (OR16-37) gene, partial cds
      gi|2921653|gb|U86236.1|U86236[2921653]
    • 12958: U86235
      Homo sapiens olfactory receptor (OR16-36) gene, partial cds
      gi|2921651|gb|U86235.1|U86235[2921651]
    • 12959: U86234
      Homo sapiens olfactory receptor (OR16-35) gene, partial cds
      gi|2921649|gb|U86234.1|U86234[2921649]
    • 12971: U86222
      Homo sapiens olfactory receptor (OR13-66) gene, partial cds
      gi|2921636|gb|U86222.1|U86222[2921636]
    • 12977: U86216
      Homo sapiens olfactory receptor (OR1-26) gene, partial cds
      gi|2921629|gb|U86216.1U86216[2921629]
    • 12978: U86215
      Homo sapiens olfactory receptor (OR1-25) gene, partial cds
      gi|2921627|gb|U86215.1|U86215[2921627]
    • 12979: AF016261
      Homo sapiens interleukin-1 receptor accessory protein (IL1RAP) gene, partial cds
      gi|2911297|gb|AF016261.1|AF016261[2911297]
    • 12980: AF041245
      Homo sapiens orexin receptor-2 mRNA, complete cds
      gi|2897127|gb|AF041245.1|AF041245[2897127]
    • 12981: AF041243
      Homo sapiens orexin receptor-1 mRNA, complete cds
      gi|2897123|gb|AF041243.1|AF041243[2897123]
    • 12982: U97123
      Homo sapiens chemokine receptor mRNA, complete cds
      gi|2897070|gb|U97123.1|HSU97123[2897070]
    • 12983: AF009014
      Homo sapiens glutamate receptor delta-2 subunit (GLURD2) mRNA, complete cds
      gi|2853314|gb|AF009014.1|AF009014[2853314]
    • 12984: AF036581
      Homo sapiens tumor necrosis factor superfamily member LIGHT mRNA, complete cds
      gi|2815623|gb|AF036581.1|AF036581[2815623]
    • 12985: AF040991
      Homo sapiens roundabout 2 (robo2) mRNA, partial cds
      gi|2804785|gb|AF040991.1|AF040991[2804785]
    • 12986: AF040990
      Homo sapiens roundabout 1 (robo1) mRNA, complete cds
      gi|2804783|gb|AF040990.1|AF040990[2804783]
    • 12987: AF026070
      Homo sapiens death receptor 3 beta (DR3) mRNA, complete cds
      gi|2570830|gb|AF026070.1|AF026070[2570830]
    • 12988: AF021818
      Homo sapiens putative neurotransmitter receptor mRNA, complete cds
      gi|2465431|gb|AF021818.1|AF021818[2465431]
    • 12990: L48211
      Homo Sapiens angiotensin II receptor gene, complete cds
      gi|1160612|gb|L48211.1|HUMAIR[1160612]
    • 12992: L47169
      Homo sapiens neuropeptide Y receptor gene, exon, promoter C
      gi|976208|gb|L47169.1|HUMNPYAC[976208]
    • 12993: L47168
      Homo sapiens neuropeptide Y receptor gene, exon, promoter B
      gi|976207|gb|L47168.1|HUMNPYAB[976207]
    • 12994: L47167
      Homo sapiens neuropeptide Y receptor gene, exon, promoter A
      gi|976206|gb|L47167.1|HUMNPYAA[976206]
    • 12995: L37086
      Homo sapiens FK-506 binding protein (fkbp12.6) gene, complete cds
      gi|965467|gb|L37086.1|HUMFK506B[965467]
    • 12996: L36566
      Human helodermin-preferring VIP receptor (VIP2/PACAP receptor) mRNA, complete cds
      gi|550477|gb|L36566.1|HUMHVP[550477]
    • 12997: L25647
      Homo sapiens fibroblast growth factor receptor gene (located in the central MHC)
      signal peptide and consecutive exon
      gi|457233|gb|L25647.1|HUMFGFRZ[457233]
    • 12998: M85247
      H. sapiens dopamine D1A receptor gene, complete exon 1, and exon 2, 5′ end
      gi|181652|gb|M85247.1|HUMDOPAM[181652]
    • 12999: L21195
      Human serotonin 5-HT7 receptor mRNA, complete cds
      gi|413865|gb|L21195.1|HLJMSHTR[413865]
    • 13000: L22647
      Human prostaglandin receptor ep1 subtype mRNA, complete cds
      gi|410208|gb|L22647.1|HUMG[410208]
    • 13001: L10822
      Human gastrin receptor gene, complete cds
      gi|406075|gb|L10822.1|HUMGARE[406075]
    • 13002: L19546
      Human (IL2RG) gene, complete cds with repeats
      gi|349631|gb|L19546.1|HUMIL2RGA[349631]
    • 13003: M95667
      Homo sapiens c-erb B2/neu protein (ERBB2) gene, partial cds
      gi|182168|gb|M95667.1|HUMERBB2[182168]
    • 13004: AF087138
      Homo sapiens sulfonylurea receptor 1 (SUR1) mRNA, complete cds
      gi|3643189|gb|AF087138.1|AF087138[3643189]
    • 13005: AF042782
      Homo sapiens galanin receptor type. 2 (GALR2) gene, complete cds
      gi|3642913|gb|AF042782.1|AF042782[3642913]
    • 13007: AF064548
      Homo sapiens low-density lipoprotein receptor-related protein 5 (LRP5) mRNA,
      complete cds
      gi|3641526|gb|AF064548.1|AF064548[3641526]
    • 13008: AF073799
      Homo sapiens galanin receptor GALR3 mRNA, complete cds
      gi|3608409|gb|AF073799.1|AF073799[3608409]
    • 13009: D10202
      Homo sapiens mRNA for platelet-activating factor receptor, complete cds
      gi|219975|dbj|D10202.1|HUMPAFRE[219975]
    • 13010: AB017498
      Homo sapiens LRP5 mRNA for Lipoprotein Receptor Related Protein 5, complete cds
      gi|3582144|dbj|AB017498.1|AB017498[3582144]
    • 13011: AJ011041
      Homo sapiens CHRM2 gene, satellite
      gi|3581973|emb|AJ011041.1|HSA011041[3581973]
    • 13012: AH006427
      Homo sapiens chromosome 12 map 12q13-14
      gi|3561040|gb|AH006427.1|SEG_HOMOVDR[3561040]
    • 13013: AF080456
      Homo sapiens vitamin D receptor gene, exon if
      gi|3561039|gb|AF080456.1|HOMOVDR3[3561039]
    • 13014: AF080455
      Homo sapiens vitamin D receptor gene, exon le
      gi|3561038|gb|AF080455.1|HOMOVDR2[3561038]
    • 13015: AF080454
      Homo sapiens vitamin D receptor gene, exon id
      gi|3561037|gb|AF080454.1|HOMOVDR1[3561037]
    • 13025: AJ001689
      Homo sapiens NKG2D gene, exon 10
      gi|2980867|emb|AJ001689.1|HSAJ1689[2980867]
    • 13026: AJ001688
      Homo sapiens NKG2D gene, exons 6-9
      gi|2980866|emb|AJ001688.1|HSAJ1688[2980866]
    • 13027: AJ001687
      Homo sapiens NKG2D gene, exons 2-5 and joined mRNA and CDS
      gi|2980864|emb|AJ001687.1|HSAJ1687[2980864]
    • 13028: AJ001686
      Homo sapiens NKG2F gene
      gi|2980862|emb|AJ001686.1|HSAJ1686[2980862]
    • 13029: AJ001685
      Homo sapiens NKG2E gene
      gi|2980860|emb|AJ001685.1|HSAJ1685[2980860]
    • 13030: AJ001684
      Homo sapiens NKG2C gene
      gi|2980858|emb|AJ001684.1|HSAJ1684[2980858]
    • 13031: AJ001683
      Homo sapiens NKG2F mRNA
      gi|2980856|emb|AJ001683.1|HSAJ1683[2980856]
    • 13032: Y12546
      H. sapiens mRNA for P2Y-like G-protein coupled receptor
      gi|2687818|emb|Y12546.1|HSP2YLG[2687818]
    • 13033: AF015525
      Homo sapiens putative chemokine receptor (CRAM-B) mRNA, complete cds
      gi|3550069|gb|AF015525.1|AF015525[3550069]
    • 13034: AF015524
      Homo sapiens putative chemokine receptor (CRAM-A) mRNA, complete cds
      gi|3550066|gb|AF015524.1|AF015524[3550066]
    • 13035: AF068868
      Homo sapiens TNFR-related death receptor-6 (DR6) mRNA, complete cds
      gi|3549262|gb|AF068868.1|AF068868[3549262]
    • 13036: AF052572
      Homo sapiens chemokine receptor CXCR4 gene, promoter region and complete cds
      gi|3549254|gb|AF052572.1|AF052572[3549254]
    • 13037: AC005625
      Homo sapiens chromosome 19, cosmid R27328, complete sequence
      gi|3549153|gb|AC005625.1|AC005625[3549153]
    • 13038: AF051152
      Homo sapiens Toll/interleukin-1 receptor-like protein 4 (TIL4) mRNA, complete cds
      gi|3132527|gb|AF051152.1|AF051152[3132527]
    • 13039: AF051151
      Homo sapiens Toll/interleukin-1 receptor-like protein 3 (TIL3) mRNA, complete cds
      gi|3132525|gb|AF051151.1|AF051151[3132525]
    • 13040: AC005601
      Homo sapiens chromosome 5, BAC clone 343g16 (LBNL H180), complete sequence
      gi|3522917|gb|AC005601.1|AC005601[3522917]
    • 13042: U88540
      Homo sapiens Toll-like receptor 1 (TLR1) mRNA, complete cds
      gi|2459617|gb|U88540.1|HSU88540[2459617]
    • 13066: Z94155
      H. sapiens mRNA for P2Y-like G-protein coupled receptor (partial)
      gi|2695875|emb|Z94155.1|HSZ94155[2695875]
    • 13067: Z94154
      H. sapiens mRNA for P2Y-like G-protein coupled receptor
      gi|2695873|emb|Z94154.1|HSZ94154[2695873]
    • 13068: AF074264
      Homo sapiens LDL receptor-related protein 6 (LRP6) mRNA, complete cds
      gi|3462526|gb|AF074264.1|AF074264[3462526]
    • 13069: AF021233
      Homo sapiens TRAIL-R4-B (TRAIL-R4) mRNA, complete cds
      gi|3452184|gb|AF021233.1|AF021233[3452184]
    • 13070: AF021232
      Homo sapiens TRAIL-R4-A (TRAIL-R4) mRNA, complete cds
      gi|3452182|gb|AF021232.1|AF021232[3452182]
    • 13072: X98765
      H. sapiens gene encoding secretory component of polymeric immunoglobulin receptor
      gi|2546984|emb|X98765.1|HSSC[2546984]
    • 13103: U50062
      Homo sapiens RIP protein kinase mRNA, complete cds
      gi|3426026|gb|U50062.1|HSU50062[3426026]
    • 13104: AF078925
      Homo sapiens P2X1 receptor gene, partial cds
      gi|3421366|gb|AF078925.1|AF078925[3421366]
    • 13106: AF061785
      Homo sapiens gamma-aminobutyric acid receptor A5 subunit (GABRA5) gene, three alternative first exons and exons 2-3, partial cds
      gi|3420025|gb|AF061785.1|AF061785[3420025]
    • 13110: AB009462
      Homo sapiens hLRp105 mRNA for LDL receptor related protein 105, complete cds
      gi|3413957|dbj|AB009462.1|AB009462[3413957]
    • 13111: AF075590
      Homo sapiens MCF-7 peripheral-type benzodiazepine receptor (PBR) mRNA, partial
      cds
      gi|3411164|gb|AF075590.1|AF075590[3411164]
    • 13112: AF075589
      Homo sapiens MDA-MB-231 peripheral-type benzodiazepine receptor (PBR) mRNA, partial cds
      gi|3411162|gb|AF075589.1|AF075589[3411162]
    • 13113: L39064
      Homo sapiens interleukin 9 receptor precursor (IL9R) gene, complete cds
      gi|632992|gb|L39064.1|HUMIL9RA[632992]
    • 13114: AJ224878
      Homo sapiens mRNA for T-cell receptor interacting molecule (TRIM) protein
      gi|3402215|emb|AJ224878.1|HSAJ4878[3402215]
    • 13115: AF080214
      Homo sapiens protease-activated receptor 4 mRNA, complete cds
      gi|3396080|gb|AF080214.1|AF080214[3396080]
    • 13116: AF075005
      Homo sapiens full length insert cDNA YH98E06
      gi|3377544|gb|AF075005.1|HUMYH98E06[3377544]
    • 13133: AF062006
      Homo sapiens orphan G protein-coupled receptor HG38 mRNA, complete cds
      gi|3366801|gb|AF062006.1|AF062006[3366801]
    • 13134: Y12815
      H. sapiens mRNA for chemokine receptor D6
      gi|2204204|emb|Y12815.1|HSY12815[2204204]
    • 13135: AC005338
      Homo sapiens chromosome 19, cosmid R31646, complete sequence
      gi|3355457|gb|AC005338.1|AC005338[3355457]
    • 13137: AF078530
      Homo sapiens receptor interacting protein 2 (RIP2) mRNA, complete cds
      gi|3342909|gb|AF078530.1|AF078530[3342909]
    • 13138: AF077526
      Homo sapiens parathyroid hormone-related protein receptor gene, partial cds
      gi|3342553|gb|AF077526.1|AF077526[3342553]
    • 13139: AH006311
      Homo sapiens chromosome 11 gastrin\cholecystokinin brain receptor (CCKBR), partial cds
      gi|3342089|gb|AH006311.1|SEG_HSCCKBR[3342089]
    • 13140: AF074029
      Homo sapiens gastrincholecystokinin brain receptor (CCKBR) gene, exons 4 and and partial cds
      gi|3342088|gb|AF074029.1|HSCCKBR2[3342088]
    • 13141: AF074035
      Homo sapiens gastrincholecystokinin brain receptor (CCKBR) gene, exons 2 and 3
      gi|3342087|gb|AF074035.1|HSCCKBR1[3342087]
    • 13142: U44132
      Homo sapiens lung cancer suppressor region LCR11.1 satellite DNA
      gi|1174163|gb|U44132.1|HSU44132[1174163]
    • 13143: Y14930
      Homo sapiens TCRAV28 gene, allele A4, partial
      gi|2664276|emb|Y14930.1|HSY14930[2664276]
    • 13144: Y14931
      Homo sapiens TCRAV28 gene, allele A5, partial
      gi|2661832|emb|Y14931.1|HSY14931[2661832]
    • 13145: Y14929
      Homo sapiens TCRAV28 gene, allele A3, partial
      gi|2661828|emb|Y14929.1|HSY14929[2661828]
    • 13146: AF074087
      Homo sapiens killer cell inhibitory receptor short form (KIR2D52) mRNA, alternatively spliced, partial cds
      gi|3328178|gb|AF074087.1|AF074087[3328178]
    • 13147: Y12507
      H. sapiens mRNA for serotonin receptor 5-HT4D, splice variant
      gi|3326990|emb|Y12507.1|HSY12507[3326990]
    • 13148: Y12506
      H. sapiens mRNA for serotonin receptor 5-HT4C, splice variant
      gi|3326988|emb|Y12506.1|HSY12506[3326988]
    • 13151: D85242
      Homo sapiens mRNA for NOR-1 3′-variant, partial cds
      gi|3168581|dbj|D85242.1D85242[3168581]
    • 13152: D85241
      Homo sapiens mRNA for NOR-1beta, partial cds
      gi|3168579|dbj|D85241.1|D85241[3168579]
    • 13153: AF034633
      Homo sapiens orphan G protein-coupled receptor (GPR39) mRNA, complete cds
      gi|2654160|gb|AF034633.1|AF034633[2654160]
    • 13154: AF034632
      Homo sapiens orphan G protein-coupled receptor (GPR38) gene, complete cds
      gi|2654158|gb|AF034632.1|AF034632[2654158]
    • 13155: AF054633
      Homo sapiens thrombin receptor gene, exon 1 and partial cds
      gi|3309036|gb|AF054633.1|AF054633[3309036]
    • 13156: AF073792
      Homo sapiens CGRP-receptor component protein mRNA, complete cds
      gi|3300101|gb|AF073792.1|AF073792[3300101]
    • 13157: AF007575
      Homo sapiens ES/130-related protein mRNA, partial cds
    • 13158: AF055917
      Homo sapiens protease-activated receptor 4 mRNA, complete cds
      gi|329332|gb|AF055917.1|AF055917[3293321]
    • 13160: AC005255
      Homo sapiens chromosome 19, CIT-HSP-146e8, complete sequence
      gi|3289998|gb|AC005255.1|AC005255[3289998]
    • 13165: AB012724
      Homo sapiens gene for endothelin-A receptor, cis_element region
      gi|3273319|dbj|AB012724.1|AB012724[3273319]
    • 13166: AB015745
      Homo sapiens mRNA for human prolactin-releasing peptide receptor, complete cds
      gi|3273224|dbj|AB015745.1|AB015745[3273224]
    • 13167: AF020498
      Homo sapiens P2X1 purinoceptor (P2X) mRNA, complete cds
      gi|3258622|gb|AF020498.1|AF020498[3258622]
    • 13170: AF051767
      Homo sapiens GDNF family receptor alpha 3 (GFRA3) mRNA, complete cds
      gi|2961631|gb|AF051767.1|AF051767[2961631]
    • 13171: AH006188
      Homo sapiens GABA-A receptor pi subunit (GABRP), partial cds
      gi|3252851|gb|AH006188.1|SEG_HSGABRP[3252851]
    • 13172: AF009702
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 10 and complete cds
      gi|3252850|gb|AF009702.1|HSGABRP10[3252850]
    • 13173: AF009701
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 9
      gi|3252849|gb|AF009701.1|HSGABRP09[3252849]
    • 13174: AF009700
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 8
      gi|3252848|gb|AF009700.1|HSGABRP08[3252848]
    • 13175: AF009699
  • Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 7
  • gi|3252847|gb|AF009699.1|HSGABRP07[3252847]
    • 13176: AF009698
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 6
      gi|3252846|gb|AF009698.1|HSGABRP06[3252846]
    • 13177: AF009697
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 5
      gi|3252845|gb|AF009697.1|HSGABRP05[3252845]
    • 13178: AF009696
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 4
      gi|3252844|gb|AF009696.1|HSGABRP04[3252844]
    • 13179: AF009695
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 3
      gi|3252843|gb|AF009695.1|HSGABRP03[3252843]
    • 13180: AF009694
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 2
      gi|3252842|gb|AF009694.1|HSGABRP02[3252842]
    • 13181: AF009693
      Homo sapiens GABA-A receptor pi subunit gene (GABRP), exon 1
      gi|3252841|gb|AF009693.1|HSGABRP01[3252841]
    • 13182: E13909
      cDNA encoding human MCP-1 receptor protein
      gi|3252676|dbj|E13909.1|E13909[3252676]
    • 13183: E13892
      cDNA encoding human novel G protein-coupling receptor protein
      gi|3252659|dbj|E13892.1|E13892[3252659]
    • 13184: E13385
      cDNA encoding human MIP-1 alpha/RANTES receptor
      gi|13252190|dbj|E13385.1|E13385[3252190]
    • 13185: E13006
      cDNA encoding human G-protein coupling receptor protein
      gi|3251830|dbj|E13006.1|E13006[3251830]
    • 13186: E13005
      cDNA encoding human G-protein-coupling receptor protein
      gi|3251829|dbj|E13005.1|E13005[3251829]
    • 13187: E12979
      cDNA encoding human interleukin-6 receptor
      gi|3251803|dbj|E12979.1|E12979[3251803]
    • 13188: E12916
      Human cDNA encoding a denatured low-density lipoprotein receptor
      gi|3251747|dbj|E12916.1|E12916[3251747]
    • 13189: E12845
      cDNA encoding melatonin receptor
      gi|3251677|dbj|E12845.1|E12845[3251677]
    • 13190: E12752
      A novel human Corticotropin Releasing Factor 2 (CRF2) receptor mRNA, complete cds
      gi|3251584|dbj|E12752.1|E12752[3251584]
    • 13191: E12750
      A novel human Corticotropin Releasing Factor 2 (CRF2) receptor mRNA, complete cds
      gi|3251582|dbj|E12750.1|E12750[3251582]
    • 13192: E12703
      cDNA encoding asialoglycoprotein receptor L-H2, AGPR L-H2
      gi|3251535|dbj|E12703.1|E12703[3251535]
    • 13193: E12702
      cDNA encoding asialoglycoprotein receptor H1, AGPR H1
      gi|3251534|dbj|E12702.1|E12702[3251534]
    • 13197: E12658
      cDNA encoding galanin receptor
      gi|3251490|dbj|E12658.1|E12658[3251490]
    • 13198: E12487
      Human cDNA encoding a G protein-coupled receptor
      gi|3251320|dbj|E12487.1|E12487[3251320]
    • 13199: E12484
      Human cDNA encoding a G protein-coupled receptor
      gi|3251317|dbj|E12484.1|E12484[3251317]
    • 13200: E12354
      cDNA encoding receptor of luteinizing hormone-releasing hormone, LH-RH receptor
      gi|3251188|dbj|E12354.1|E12354[3251188]
    • 13201: E12281
      cDNA encoding human growth hormone-releasing hormone receptor
      gi|3251115|dbj|E12281.1|E12281[3251115]
    • 13202: E12186
      A novel ligand for receptor type tyrosine kinase
      gi|3251020|dbj|E12186.1|E12186[3251020]
    • 13203: E12185
      cDNA encoding a receptor type tyrosine kinase
      gi|3251019|dbj|E12185.1|E12185[3251019]
    • 13204: AF009962
      Homo sapiens CC-chemokine receptor (CCR-5) gene, delta-32 allele, complete cds
      gi|3243092|gb|AF009962.1|AF009962[3243092]
    • 13205: AF050525
      Homo sapiens proteinase activated receptor-3 (PAR-3) gene, 5′ regulatory sequence
      gi|3241996|gb|AF050525.1|AF050525[3241996]
    • 13206: U33328
      Homo sapiens killer cell Ig-like receptor variant (KIR3DL1) mRNA, complete cds
      gi|995756|gb|U33328.1|HSU33328[995756]
    • 13207: U31416
      Homo sapiens killer cell Ig-like receptor (KIR3DL1) mRNA, complete cds
      gi|973405|gb|U31416.1|HSU31416[973405]
    • 13208: U50748
      Homo sapiens leptin receptor short form (db) mRNA, complete cds
      gi|3236285|gb|U50748.1|HSU50748[3236285]
    • 13215: Y14838
      Homo sapiens ChemR23 gene
      gi|3219597|emb|Y14838.1|HSCHEMR23[3219597]
    • 13216: Y12505
      H. sapiens mRNA for serotonin receptor 5-HT4B, splice variant
      gi|2661756|emb|Y12505.1|HSY12505[2661756]
    • 13217: Y08756
      H. sapiens mRNA for serotonin receptor 5-HT4
      gi|2661732|emb|Y08756.1|HS5HT4AR[2661732]
    • 13218: X85785
      H. sapiens DARC gene
      gi|929624|emb|X85785.1|HSDARC[929624]
    • 13219: AH006173
      Homo sapiens Type II integral membrane protein (NKG2-F), complete cds
      gi|2674028|gb|AH006173.1|SEG_HSNKG2F0[2674028]
    • 13220: AF001298
      Homo sapiens type II integral membrane protein (NKG2-D) gene, exons 9-13
      gi|2674027|gb|AF001298.1|HSNKG2F02[2674027]
    • 13221: AF001297
      Homo sapiens type II integral membrane protein (NKG2-D) gene, exons 5-8
      gi|2674026|gb|AF001297.1|HSNKG2F01[2674026]
    • 13222: AF048704
      Homo sapiens lamin B receptor homolog TM7SF2 gene, complete cds
      gi|3211743|gb|AF048704.1|AF048704[3211743]
    • 13223: AF023676
      Homo sapiens lamin B receptor homolog TM7SF2 (TM7SF2) mRNA, complete cds
      gi|3211721|gb|AF023676.1|AF023676[3211721]
    • 13224: AJ001016
      Homo sapiens mRNA encoding RAMP3
      gi|3171913|emb|AJ001016.1|HSRAMP3[3171913]
    • 13236: Y13584
      Homo sapiens mRNA for serotin receptor 4, short splice variant
      gi|3183985|emb|Y13584.1|HSY13584[3183985]
    • 13237: AF030339
      Homo sapiens receptor for viral semaphorin protein (VESPR) mRNA, complete cds
      gi|3176761|gb|AF030339.1|AF030339[3176761]
    • 13239: AC004782
      Homo sapiens chromosome 5, BAC clone 205e20 (LBNL H170), complete sequence
      gi|3172145|gb|AC004782.1|AC004782[3172145]
    • 13240: AF009662
      Homo sapiens T cell receptor beta locus, TCRBV13S1 to TCRBV6S9 region
      gi|2275573|gb|AF009662.1|HSTCRBB27[2275573]
    • 13241: AJ001015
      Homo sapiens mRNA encoding RAMP2
      gi|3171911|emb|AJ001015.1|HSRAMP2[3171911]
    • 13242: AJ001014
      Homo sapiens mRNA encoding RAMP1
      gi|3171909|emb|AJ001014.1|HSRAMP1[3171909]
    • 13243: AF011333
      Homo sapiens DEC-205 mRNA, complete cds
      gi|3165456|gb|AF011333.1|AF011333[3165456]
    • 13244: AJ001902
      Homo sapiens mRNA for TRIP6 (thyroid receptor interacting protein)
      gi|2558591|emb|AJ001902.1|HSTRIP6[2558591]
    • 13245: AF002216
      AF002216 AP20 melanoma mRNA Homo sapiens cDNA, mRNA sequence
      gi|2895065|gb|AF002216.1|AF002216[2895065]
    • 13246: AF002215
      AF002215 AP20 melanoma mRNA Homo sapiens cDNA, mRNA sequence
      gi|2895064|gb|AF002215.1|AF002215[2895064]
    • 13247: AF002214
      AF002214 AP20 melanoma mRNA Homo sapiens cDNA, mRNA sequence
      gi|2895063|gb|AF002214.1|AF002214[2895063]
    • 13248: AC002411
      Arabidopsis thaliana chromosome 1 BAC F20D22 sequence, complete sequence
      gi|2570223|gb|AC002411.1|F20D22[2570223]
    • 13249: AF058927
      Homo sapiens clone hvRNA92 vRNA sequence
      gi|3138979|gb|AF058927.1|AF058927[3138979]
    • 13250: AF058926
      Homo sapiens clone hvRNA82 vRNA sequence
      gi|3138978|gb|AF058926.1|AF058926[3138978]
    • 13252: AC004699
      Homo sapiens chromosome 19, cosmid R31973, complete sequence
      gi|3138892|gb|AC004699.1|AC004699[3138892]
    • 13253: Y13472
      Homo sapiens mRNA for FIM protein
      gi|3135791|emb|Y13472.1|HSRIMP[3135791]
    • 13254: AF015452
      Homo sapiens Usurpin-gamma mRNA, complete cds
      gi|3133284|gb|AF015452.1|AF015452[3133284]
    • 13255: AF015451
      Homo sapiens Usurpin-beta mRNA, complete cds
      gi|3133282|gb|AF015451.1|AF015451[3133282]
    • 13256: AF015450
      Homo sapiens Usurpin-alpha mRNA, complete cds
      gi|3133280|gb|AF015450.1|AF015450[3133280]
    • 13257: AF063658
      Homo sapiens vascular endothelial growth factor receptor 2 (KDR) mRNA, complete
      cds
      gi|3132832|gb|AF063658.1|AF063658[3132832]
    • 13258: AJ224869
      Homo sapiens CXCR4 gene encoding receptor CXCR4
      gi|3059119|emb|AJ224869.1|HSA224869[3059119]
    • 13259: AH006106
      Homo sapiens apoptosis signaling receptor FAS (FAS) and apoptosis signaling receptor FAS (FAS)s, partial cds
      gi|3128402|gb|AH006106.1|SEG_HSASRFAS[3128402]
    • 13260: AF061979
      Homo sapiens apoptosis signaling receptor FAS (FAS) gene, exon 7 and partial cds
      gi|3128401|gb|AF061979.1|HSASRFAS2[3128401]
    • 13261: AF061978
      Homo sapiens apoptosis signaling receptor FAS (FAS) gene, exons 6 and 7 and partial cds
      gi|3128400|gb|AF061978.1|HSASRFAS1[3128400]
    • 13262: AH006105
      Homo sapiens sulfonylurea receptor type (SUR2) gene, alternative splice products, complete cds
      gi|3127174|gb|AH006105.1|SEG_HSSUR2G[3127174]
    • 13263: AF061324
      Homo sapiens sulfonylurea receptor 2B (SUR2) gene, alternatively spliced product, exon 38b and complete cds
      gi|3127173|gb|AF061324.1|HSSUR2G71[3127173]
    • 13264: AF061323
      Homo sapiens sulfonylurea receptor 2A (SUR2) gene, alternatively spliced product, exon 38a and complete cds
      gi|3127172|gb|AF061323.1|HSSUR2G69[3127172]
    • 13265: AF061322
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 37
      gi|3127171|gb|AF061322.1|HSSUR2G67[3127171]
    • 13266: AF061321
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 36
      gi|3127170|gb|AF061321.1HSSUR2G65[3127170]
    • 13267: AF061320
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 35
      gi|3127169|gb|AF061320.1|HSSUR2G63[3127169]
    • 13268: AF061319
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 34
      gi|3127168|gb|AF061319.1|HSSUR2G61[3127168]
    • 13269: AF061318
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 33
      gi|3127167|gb|AF061318.1|HSSUR2G59[3127167]
    • 13270: AF061317
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 32
      gi|3127166|gb|AF061317.1|HSSUR2G57[3127166]
    • 13271: AF061316
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 31
      gi|3127165|gb|AF061316.1|HSSUR2G55[3127165]
    • 13272: AF061315
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 30
      gi|3127164|gb|AF061315.1|HSSUR2G53[3127164]
    • 13273: AF061314
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 29
      gi|3127163|gb|AF061314.1|HSSUR2G51[3127163]
    • 13274: AF061313
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 28
      gi|3127162|gb|AF061313.1|HSSUR2G49[3127162]
    • 13275: AF061312
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 27
      gi|3127161|gb|AF061312.1|HSSUR2G47[3127161]
    • 13276: AF061311
      Homo sapiens sulfonylurea receptor (SUR2) gene, exons 25 and 26
      gi|3127160|gb|AF061311.1|HSSUR2G45[3127160]
    • 13277: AF061310
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 24
      gi|3127159|gb|AF061310.1|HSSUR2G43[3127159]
    • 13278: AF061309
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 23
      gi|3127158|gb|AF061309.1|HSSUR2G41[3127158]
    • 13279: AF061308
      Homo sapiens sulfonylurea receptor (SUR2) gene, exons 21 and 22
      gi|3127157|gb|AF061308.1|HSSUR2G39[3127157]
    • 13280: AF061307
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 20
      gi|3127156|gb|AF061307.1|HSSUR2G37[3127156]
    • 13281: AF061306
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 19
      gi|3127155|gb|AF061306.1|HSSUR2G35[3127155]
    • 13282: AF061305
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 18
      gi|3127154|gb|AF061305.1|HSSUR2G33[3127154]
    • 13283: AF061304
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 17
      gi|3127153|gb|AF061304.1|HSSUR2G31[3127153]
    • 13284: AF061303
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 16
      gi|3127152|gb|AF061303.1|HSSUR2G29[3127152]
    • 13285: AF061302
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 15
      gi|3127151|gb|AF061302.1|HSSUR2G27[3127151]
    • 13286: AF061301
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 14
      gi|3127150|gb|AF061301.1|HSSUR2G25[3127150]
    • 13287: AF061300
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 13
      gi|3127149|gb|AF061300.1|HSSUR2G23[3127149]
    • 13288: AF061299
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 12
      gi|3127148|gb|AF061299.1|HSSUR2G21[3127148]
    • 13289: AF061298
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 11
      gi|3127147|gb|AF061298.1|HSSUR2G19[3127147]
    • 13290: AF061297
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 10
      gi|3127146|gb|AF061297.1|HSSUR2G17[3127146]
    • 13291: AF061296
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 9
      gi|3127145|gb|AF061296.1|HSSUR2G15[3127145]
    • 13292: AF061295
      Homo sapiens sulfonylurea receptor (SUR2) gene, exons 7 and 8
      gi|3127144|gb|AF061295.1|HSSUR2G13[3127144]
    • 13293: AF061294
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 6
      gi|3127143|gb|AF061294.1|HSSUR2G11[3127143]
    • 13294: AF061293
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 5
      gi|3127142|gb|AF061293.1|HSSUR2G09[3127142]
    • 13295: AF061292
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 4
      gi|3127141|gb|AF061292.1|HSSUR2G07[3127141]
    • 13296: AF061291
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 3
      gi|3127140|gb|AF061291.1|HSSUR2G05[3127140]
    • 13297: AF061290
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 2
      gi|3127139|gb|AF061290.1|HSSUR2G03[3127139]
    • 13298: AF061289
      Homo sapiens sulfonylurea receptor (SUR2) gene, exon 1
      gi|3127138|gb|AF061289.1|HSSUR2G01[3127138]
    • 13299: U77783
      Homo sapiens N-methyl-D-aspartate receptor 2D subunit precursor (NMDAR2D) mRNA,
      complete cds
      gi|2444025|gb|U77783.1|HSU77783[2444025]
    • 13300: AJ001515
      Homo sapiens mRNA for ryanodine receptor 3, complete CDS
      gi|3123583|emb|AJ001515.1|HSRYR3[3123583]
    • 13302: AJ002512
      Homo sapiens mRNA for ryanodine receptor 3, partial
      gi|2582750|emb|AJ002512.1|HSAJ2512[2582750]
    • 13303: AJ002511
      Homo sapiens mRNA for ryanodine receptor 2, partial
      gi|2582748|emb|AJ002511.1HSAJ2511[2582748]
    • 13315: Z81148
      H. sapiens mRNA for gonadotropin-releasing hormone receptor, splice variant
      gi|1628389|emb|Z81148.1|HSGTRHSV[1628389]
    • 13316: U71092
      Homo sapiens somatostatin receptor-like protein (GPR24) gene, complete cds
      gi|1737178|gb|U71092.1|HSU71092[1737178]
    • 13317: AH006056
      Homo sapiens chromosome 10 clone BAC 73106 map 10q25-q26
      gi|3068782|gb|AH006056.1|SEG_HSGFRA1H[3068782]
    • 13318: AF058999
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 11 and complete cds
      gi|3068781|gb|AF058999.1|HSGFRA1H10[3068781]
    • 13319: AF058998
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 10
      gi|3068780|gb|AF058998.1|HSGFRA1H09[3068780]
    • 13320: AF058997
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 9
      gi|3068779|gb|AF058997.1|HSGFRA1H08[3068779]
    • 13321: AF058996
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 8
      gi|3068778|gb|AF058996.1|HSGFRA1H07[3068778]
    • 13322: AF058995
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 7
      gi|3068777|gb|AF058995.1|HSGFRA1H06[3068777]
    • 13323: AF058994
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 6
      gi|3068776|gb|AF058994.1|HSGFRA1H05[3068776]
    • 13324: AF058993
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 5
      gi|3068775|gb|AF058993.1|HSGFRA1H04[3068775]
    • 13325: AF058992
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 4
      gi|3068774|gb|AF058992.1|HSGFRA1H03[3068774]
    • 13326: AF058991
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 3
      gi|3068773|gb|AF058991.1|HSGFRA1H02[3068773]
    • 13327: AF058990
      Homo sapiens glial cell line-derived neurotrophic factor receptor alpha (GFRA1)
      gene, exon 2
      gi|3068772|gb|AF058990.1|HSGFRA1H01[3068772]
    • 13328: AF044197
      Homo sapiens B lymphocyte chemoattractant BLC mRNA, complete cds
      gi|2911375|gb|AF044197.1|AF044197[2911375]
    • 13329: Y16280
      Homo sapiens mRNA for G protein-coupled receptor ETBR-LP-2
      gi|3059117|emb|Y16280.1|HSETBRLP2[3059117]
    • 13330: U16260
      Neisseria gonorrheae lactoferrin receptor precursor (lbpA) gene, complete cds
      gi|915277|gb|U16260.1|NGU16260[915277]
    • 13331: AF057177
      Homo sapiens T-cell receptor gamma V1 gene region
      gi|3047019|gb|AF057177.1|AF057177[3047019]
    • 13333: AF057168
      Homo sapiens type II interleukin-1 receptor antagonist (IL-1ra3) gene, partial
      cds
      gi|3046605|gb|AF057168.1|AF057168[3046605]
    • 13334: L06155
      Homo sapiens melanocortin receptor gene, complete cds
      gi|188673|gb|L06155.1|HUMMR[188673]
    • 13335: L27490
      Homo sapiens prostanoid EP3-I receptor mRNA, complete cds
      gi|440313|gb|L27490.1|HUMPEIRB[440313]
    • 13336: L27489
      Homo sapiens prostanoid EP3-III receptor mRNA, complete cds
      gi|44031|gb|L27489.1|HUMPEIRA[440311]
    • 13337: L27488
      Homo sapiens prostanoid EP3-II receptor mRNA, complete cds
      gi|440309|gb|L27488.1|HUMPEIR[440309]
    • 13338: AF009664
      Homo sapiens T cell receptor beta locus, 3′ trypsinogen repeats
      gi|2275594|gb|AF009664.1|HSTCRB1H[2275594]
    • 13339: AF009660
      Homo sapiens T cell receptor beta locus, TCRBV7S3A2 to TCRBV12S2 region
      gi|2275560|gb|AF009660.1|HSTCRBK17[2275560]
    • 13340: AB006537
      Homo sapiens mRNA for interleukin 1 receptor accessory protein, complete cds
      gi|3041772|dbj|AB006537.1|AB006537[3041772]
    • 13341: AF016098
      Homo sapiens vascular endothelial cell growth factor 165 receptor 2 (VEGF165R2)
      mRNA, complete cds
      gi|2978561|gb|AF016098.1|AF016098[2978561]
    • 13342: AF016050
      Homo sapiens vascular endothelial cell growth factor 165 receptor/neuropilin (VEGF165) mRNA, complete cds
      gi|2978559|gb|AF016050.1|AF016050[2978559]
    • 13343: U90941
      Homo sapiens cell-type natural killer cells Fc gamma receptor RIIc4 (Fc-gammaRIIC) mRNA, complete cds
      gi|214963|gb|U90941.1|HSU90941[2149631]
    • 13344: U90940
      Homo sapiens cell-type natural killer cells Fc gamma receptor IIc3 (Fc-gammaRIIC) mRNA, complete cds
      gi|2149629|gb|U90940.1|HSU90940[2149629]
    • 13345: U90939
      Homo sapiens cell-type natural killer cells Fc gamma receptor IIc2 (Fc-gammaRIIC) mRNA, complete cds
      gi|2149627|gb|U90939.1|HSU90939[2149627]
    • 13346: U90938
      Homo sapiens cell-type natural killer cells Fc gamma receptor IIc1 (Fc-gammaRIIC) mRNA, complete cds
      gi|2149625|gb|U90938.1|HSU90938[2149625]
    • 13348: Y14739
      Homo sapiens CXCR4 gene
      gi|3021393|emb|Y14739.1|HSCXCR4[3021393]
    • 13349: Y07683
      H. sapiens mRNA for P2X3 purinoceptor
      gi|2370146|emb|Y07683.1|HSP2X3PC[2370146]
    • 13350: AF027390
      Homo sapiens 7q telomere, complete sequence
      gi|3004858|gb|AF027390.1|AF027390[3004858]
    • 13351: U04357
      Homo sapiens arginine vasopressin receptor type 11, V2 antidiuretic hormone receptor (AVPR2) gene, complete cds
      gi|3004498|gb|U04357.1|HSU04357[3004498]
    • 13352: AH006005
      Homo sapiens TGF-beta type I receptor (TGFBR1), complete cds
      gi|3003037|gb|AH006005.1|SEG_HSTGFBR1G[3003037]
    • 13353: AF054598
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 9 and complete cds
      gi|3003036|gb|AF054598.1|HSTGFBR1G9[3003036]
    • 13354: AF054597
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 8
      gi|3003035|gb|AF054597.1|HSTGFBR1G8[3003035]
    • 13355: AF054596
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 7
      gi|3003034|gb|AF054596.1|HSTGFBR1G7[3003034]
    • 13356: AF054595
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 6
      gi|3003033|gb|AF054595.1|HSTGFBR1G6[3003033]
    • 13357: AF054594
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 5
      gi|3003032|gb|AF054594.1|HSTGFBR1G5[3003032]
    • 13358: AF054593
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 4
      gi|3003031|gb|AF054593.1|HSTGFBR1G4[3003031]
    • 13359: AF054592
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 3
      gi|3003030|gb|AF054592.1|HSTGFBR1G3[3003030]
    • 13360: AF054591
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 2
      gi|3003029|gb|AF054591.1|HSTGFBR1G2[3003029]
    • 13361: AF054590
      Homo sapiens TGF-beta type I receptor (TGFBR1) gene, exon 1
      gi|3003028|gb|AF054590.1|HSTGFBR1G1[3003028]
    • 13362: L12406
      Homo sapiens chemoattractant receptor (fMLP) gene sequence
      gi|348164|gb|L12406.1|HUMCR[348164]
    • 13363: AC004510
      Homo sapiens chromosome 19, cosmid R30385, complete sequence
      gi|12996651|gb|AC004510.1|AC004510[29969551]
    • 13364: U84721
      Homo sapiens interferon gamma receptor 1 gene, microsatellite sequence
      gi|2982188|gb|U84721.1|HSU84721[2982188]
    • 13365: AF013261
      Homo sapiens alpha 1A adrenergic receptor isoform 4 mRNA, complete cds
      gi|2978555|gb|AF013261.1|AF013261[2978555]
    • 13369: AF014794
      Homo sapiens TNF related TRAIL receptor (TRAIL-R3) mRNA, complete cds
      gi|2957263|gb|AF014794.1|AF014794[2957263]
    • 13372: AC003658
      Homo sapiens Xp22 BAC GS-607H18 (Genome Systems Human BAC library) complete sequence
      gi|2935592|gb|AC003658.1|AC003658[2935592]
    • 13375: AH005897
      Homo sapiens type I sigma receptor, complete cds
      gi|2914739|gb|AH005897.1|SEG_HSTIRG[2914739]
    • 13376: AF001977
      Homo sapiens type I sigma receptor gene, exon 4 and complete cds
      gi|2914738|gb|AF001977.1|HSTIRG3[2914738]
    • 13377: AF001976
      Homo sapiens type I sigma receptor gene, exons 1, 2 and 3
      gi|2914737|gb|AF001976.1|HSTIRG2[2914737]
    • 13486: U78192
      Homo sapiens Edg-2 receptor mRNA, complete cds
      gi|1688304|gb|U78192.1|HSU78192[1688304]
    • 13488: AF044492
      Homo sapiens olfactory receptor-like protein (OLFR42A) gene, allele 9092.1, partial cds
      gi|2828698|gb|AF044492.1|AF044492[2828698]
    • 13489: AF044491
      Homo sapiens olfactory receptor-like protein (OLFR42A) gene, allele 9004.14, partial cds
      gi|2828696|gb|AF044491.1|AF044491[2828696]
    • 13490: AF042078
      Homo sapiens olfactory receptor-like protein (OLFR42A) gene, OLFR42A-9026.2 allele, partial cds
      gi|282868|gb|AF042078.1|AF042078[2828681]
    • 13491: AB010710
      Homo sapiens mRNA for lectin-like oxidized LDL receptor, complete cds
      gi|2828355|dbj|AB010710.1|AB010710[2828355]
    • 13492: AF041462
      Homo sapiens I-FLICE isoform 5 mRNA, complete cds
      gi|2827297|gb|AF041462.1|AF041462[2827297]
    • 13493: AF041461
      Homo sapiens I-FLICE isoform 4 mRNA, complete cds
      gi|2827295|gb|AF041461.1|AF041461[2827295]
    • 13494: AF041460
      Homo sapiens I-FLICE isoform 3 mRNA, complete cds
      gi|2827293|gb|AF041460.1|AF041460[2827293]
    • 13495: AF041459
      Homo sapiens I-FLICE isoform 2 mRNA, complete cds
      gi|2827291|gb|AF041459.1|AF041459[2827291]
    • 13496: AF041458
      Homo sapiens I-FLICE mRNA, complete cds
      gi|2827289|gb|AF041458.1|AF041458[2827289]
    • 13497: Z73157
      H. sapiens mRNA for C3a anaphylatoxin receptor
      gi|2826756|emb|Z73157.1|HSC3AAREC[2826756]
    • 13498: U58917
      Homo sapiens IL-17 receptor mRNA, complete cds
      gi|2826475|gb|U58917.1|HSU58917[2826475]
    • 13524: Y16282
      Homo sapiens mRNA for nicotinic acetylcholine receptor alpha6 subunit precursor
      gi|2815224|emb|Y16282.1|HSY16282[2815224]
    • 13525: Y16281
      Homo sapiens mRNA for nicotinic acetylcholine receptor alpha2 subunit precursor
      gi|2815222|emb|Y16281.1|HSY16281[2815222]
    • 13526: X98858
      H. sapiens mRNA for HLA-C specific activatory NK receptor
      gi|1419593|emb|X98858.1|HSNKREC[1419593]
    • 13527: M76676
      Homo sapiens leukocyte platelet-activating factor receptor mRNA, complete cds
      gi|2810988|gb|M76676.1|HUMNPIIY20[2810988]
    • 13528: Y08420
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha7 subunit precursor
      gi|2808623|emb|Y08420.1|HSNACHRA7[2808623]
    • 13529: Y08419
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha5 subunit precursor
      gi|1702913|emb|Y08419.1|HSNACHRA5[1702913]
    • 13530: Y08421
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha4 subunit precursor
      gi|1702911|emb|Y08421.1|HSNACHRA4[1702911]
    • 13531: Y08417
      H. sapiens mRNA for nicotinic acetylcholine receptor beta3 subunit precursor
      gi|1702909|emb|Y08417.1|HSNACHR3B[1702909]
    • 13532: Y08416
      H. sapiens mRNA for nicotinic acetylcholine receptor beta4 subunit precursor
      gi|1702919|emb|Y08416.1|HSNACHRB4[1702919]
    • 13533: Y08415
      H. sapiens mRNA for nicotinic acetylcholine receptor beta2 subunit precursor
      gi|1702917|emb|Y08415.1|HSNACHRB2[1702917]
    • 13534: Y08418
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha3 subunit precursor
      gi|1702907|emb|Y08418.1|HSNACHR3A[1702907]
    • 13536: AF042077
      Homo sapiens olfactory receptor-like protein (OLFR 42B) gene, OLFR 42B-9079.6 allele, partial cds
      gi|2801710|gb|AF042077.1|AF042077[2801710]
    • 13537: AF042076
      Homo sapiens olfactory receptor-like protein (OLFR 42B) gene, OLFR 42B-9108.1 allele, partial cds
      gi|2801708|gb|AF042076.1|AF042076[2801708]
    • 13538: AF042075
      Homo sapiens olfactory receptor-like protein (OLFR 428) gene, OLFR 42B-9110 allele, partial cds
      gi|2801706|gb|AF042075.1|AF042075[2801706]
    • 13539: AF042074
      Homo sapiens olfactory receptor-like protein (OLFR 42A) gene, OLFR 42A-9079.3 allele, partial cds
      gi|2801704|gb|AF042074.1|AF042074[2801704]
    • 13540: AF042073
      Homo sapiens olfactory receptor-like protein (OLFR 42A) gene, OLFR 42A-9049 allele, partial cds
      gi|2801702|gb|AF042073.1|AF042073[2801702]
    • 13600: Y10530
      H. sapiens gene encoding putative olfactory receptor (clone htpcr2)
      gi|2792017|emb|Y10530.1|HSHTPCR2[2792017]
    • 13601: Y10529
      H. sapiens mRNA for putative olfactory receptor (clone ht2)
      gi|2792015|emb|Y10529.1|HSHT2[2792015]
    • 13614: Z26876
      H. sapiens gene for ribosomal protein L38
      gi|407422|emb|Z26876.1|HSRPL38[407422]
    • 13615: Z50150
      H. sapiens mRNA for tyrosine kinase activator protein 1 (TKA-1)
      gi|1246762|emb|Z50150.1|HSTKA1MR[1246762]
    • 13616: Y13055
      Homo sapiens mRNA for NKG2-CII activating NK receptor
      gi|2765292|emb|Y13055.1|HSNKG2CII[2765292]
    • 13617: Y13054
      Homo sapiens mRNA for NK receptor, clone GR #29
      gi|2765290|emb|Y13054.1|HSNKREC29[2765290]
    • 13618: Y10437
      H. sapiens mRNA for serotonin receptor 4
      gi|2765076|emb|Y10437.1|HSSERR4[2765076]
    • 13619: AJ002105
      Homo sapiens mRNA for NK receptor, clone library TG14#13
      gi|2764706|emb|AJ002105.1|HSAJ2105[2764706]
    • 13620: AJ002104
      Homo sapiens mRNA for NK receptor, clone library TG14#6
      gi|2764704|emb|AJ002104.1|HSAJ2104[2764704]
    • 13621: AJ002103
      Homo sapiens mRNA for NK receptor, clone library TG14#35
      gi|2764702|emb|AJ002103.1|HSAJ2103[2764702]
    • 13622: AJ002102
      Homo sapiens mRNA for NK receptor, clone library TG14#8
      gi|2764700|emb|AJ002102.1|HSAJ2102[2764700]
    • 13623: AJ000001
      Homo sapiens mRNA for CD94-B NK receptor
      gi|2764393|emb|AJ000001.1|HSCD94B[2764393]
    • 13624: Y10141
      H. sapiens DAT1 gene, partial, VNTR
      gi|1752665|emb|Y10141.1|HSDAT1[1752665]
    • 13625: Z97213
      Homo sapiens mRNA for T-cell receptor
      gi|2239129|emb|Z97213.1|HSTCRBV2S[2239129]
    • 13627: AF026263
      Homo sapiens muscarinic receptor (CHRM5) mRNA, complete cds
      gi|2605721|gb|AF026263.1|AF026263[2605721]
    • 13628: AF026261
      Homo sapiens histamine H1 receptor mRNA, complete cds
      gi|2605717|gb|AF026261.1|AF026261[2605717]
    • 13629: AF026260
      Homo sapiens vitamin D receptor (VDR) mRNA, complete cds
      gi|2605715|gb|AF026260.1|AF026260[2605715]
    • 13630: AH005786
      Homo sapiens CC chemokine receptor 5 (CCR5) gene, complete cds
      gi|2739498|gb|AH005786.1|SEG_HSCCR5AB[2739498]
    • 13631: AF031237
      Homo sapiens CC chemokine receptor 5 (CCR5) gene, complete cds
      gi|2739497|gb|AF031237.1|HSCCR5AB3[2739497]
    • 13633: AH005782
      Homo sapiens chromosome X map Xq28
      gi|2735348|gb|AH005782.1|SEG_HSGABRE[2735348]
    • 13634: AF037334
      Homo sapiens Eph-like receptor tyrosine kinase hEphB1d (EphB1) mRNA, complete cds
      gi|2739209|gb|AF037334.1|AF037334[2739209]
    • 13635: AF037333
      Homo sapiens Eph-like receptor tyrosine kinase hEphB1c (EphB1) mRNA, complete cds
      gi|2739207|gb|AF037333.1|AF037333[2739207]
    • 13636: AF011406
      Homo sapiens corticotropin releasing hormone receptor type 2 beta isoform (CRH2R) mRNA, complete cds
      gi|2738557|gb|AF011406.1|AF011406[2738557]
    • 13637: U59632
      Homo sapiens H5 mRNA, partial cds; and platelet glycoprotein Ib beta chain mRNA,
      complete cds
      gi|1809264|gb|U59632.1|HSU59632[1809264]
    • 13638: D86864
      Homo sapiens mRNA for acetyl LDL receptor, complete cds
      gi|2723468|dbj|D586864.1|D86864[2723468]
    • 13639: AF027208
      Homo sapiens AC133 antigen mRNA, complete cds
      gi|2688948|gb|AF027208.1|AF027208[2688948]
    • 13640: AB001025
      Homo sapiens mRNA for brain ryanodine receptor, complete cds
      gi|2696014|dbj|AB001025.1|AB001025[2696014]
    • 13641: D00017
      Homo sapiens mRNA for lipocortin II, complete cds
      gi|219909|dbj|D00017.1|HUMLIC[219909]
    • 13642: Y08236
      H. sapiens LRP gene, polymorphisms in intron 24
      gi|2125808|emb|Y08236.1|HSLRPIN24[2125808]
    • 13644: AF025998
      Homo sapiens atrial natriuretic peptide clearance receptor (ANPRC) mRNA, complete cds
      gi|2570851|gb|AF025998.1|AF025998[2570851]
    • 13645: AD000671
      Homo sapiens DNA from chromosome 19-cosmid f24109 containing HRX2, genomic sequence
      gi|1905893|gb|AD000671.1|AD000671[1905893]
    • 13646: Z49119
      H. sapiens mRNA for serotonin 6 receptor (5-HT6; partial)
      gi|984128|emb|Z49119.1|HS5HT6[984128]
    • 13647: Z48150
      H. sapiens 5-HT4 mRNA for serotonin 4 receptor (5-HT4)
      gi|984126|emb|Z48150.1|HS5HT4[984126]
    • 13648: Y15743
      Homo sapiens RET proto-oncogene, exon 13 containing two mutations
      gi|2665353|emb|Y15743.1|HSRET13[2665353]
    • 13649: AF000575
      Homo sapiens clone 16 immunoglobulin-like transcript 5 mRNA, complete cds
      gi|2264428|gb|AF000575.1|AF000575[2264428]
    • 13650: AF000574
      Homo sapiens clone 1 immunoglobulin-like transcript 4 mRNA, complete cds
      gi|2264426|gb|AF000574.1|AF000574[2264426]
    • 13651: Z26652
      H. sapiens FLT3 mRNA for FLT3 receptor tyrosine kinase
      gi|406322|emb|Z26652.1|HSFLT3RTK[406322]
    • 13653: X82208
      H. sapiens mRNA for beta-centractin (ATCC# HHCPJ76)
      gi|563887|emb|X82208.1|HSBCENTR[563887]
    • 13654: AF035261
      Homo sapiens thyroid stimulating hormone receptor (TSHR) mRNA, partial cds
      gi|2654195|gb|AF035261.1|HSTSHR[2654195]
    • 13655: AF032388
      Homo sapiens vasopressin receptor type 2 mRNA, alternatively spliced, complete
      cds
      gi|2654030|gb|AF032388.1|AF032388[2654030]
    • 13656: AF025534
      Homo sapiens leucocyte immunoglobulin-like receptor-8 (LIR-8) mRNA, complete cds
      gi|2653874|gb|AF025534.1|AF025534[2653874]
    • 13657: AF025533
      Homo sapiens leucocyte immunoglobulin-like receptor-3 (LIR-3) mRNA, complete cds
      gi|2653872|gb|AF025533.1|AF025533[2653872]
    • 13658: AF025532
      Homo sapiens leucocyte immunoglobulin-like receptor-5 (LIR-5) mRNA, complete cds
      gi|2653870|gb|AF025532.1|AF025532[2653870]
    • 13659: AF025531
      Homo sapiens leucocyte immunoglobulin-like receptor-7 (LIR-7) mRNA, complete cds
      gi|2653868|gb|AF025531.1|AF025531[2653868]
    • 13660: AF025530
      Homo sapiens leucocyte immunoglobulin-like receptor-6a (LIR-6) mRNA, complete cds
      gi|2653866|gb|AF025530.1|AF025530[2653866]
    • 13661: AF025529
      Homo sapiens leucocyte immunoglobulin-like receptor-6b (LIR-6) mRNA, complete cds
      gi|2653864|gb|AF025529.1|AF025529[2653864]
    • 13662: AF025528
      Homo sapiens leucocyte immunoglobulin-like receptor-2 (LIR-2) mRNA, complete cds
      gi|2653862|gb|AF025528.1|AF025528[2653862]
    • 13663: AF025527
      Homo sapiens leucocyte immunoglobulin-like receptor-4 (LIR-4) mRNA, complete cds
      gi|2653860|gb|AF025527.1|AF025527[2653860]
    • 13664: Y13583
      Homo sapiens mRNA for G-protein coupled receptor
      gi|2652933|emb|Y13583.1|HSGPCP[2652933]
    • 13665: Y13367
      H. sapiens mRNA for phosphoinositide 3-kinase
      gi|2143259|emb|Y13367.1|HSPHOSI3K[2143259]
    • 13666: X82207
      H. sapiens mRNA for beta-centractin (PC3)
      gi|563885|emb|X82207.1|HSBCENT[563885]
    • 13667: AF033854
      Homo sapiens lymphocyte inhibitor of TRAIL (LIT) mRNA, complete cds
      gi|2645841|gb|AF033854.1|AF033854[2645841]
    • 13668: X81882
      H. sapiens mRNA for for vasopressin activated calcium mobilizing receptor-like protein
      gi|1628414|emb|X81882.1|HSVACM1[1628414]
    • 13669: AF024690
      Homo sapiens putative G protein-coupled receptor (GPR43) gene, complete cds
      gi|2612951|gb|AF024690.1|AF024690[2612951]
    • 13670: AF024689
      Homo sapiens putative G protein-coupled receptor (GPR42) gene, complete cds
      gi|2612949|gb|AF024689.1|AF024689[2612949]
    • 13671: AF024688
      Homo sapiens putative G protein-coupled receptor (GPR41) gene, complete cds
      gi|2612947|gb|AF024688.1|AF024688[2612947]
    • 13672: AF024687
      Homo sapiens putative G protein-coupled receptor (GPR40) gene, complete cds
      gi|2612945|gb|AF024687.1|AF024687[2612945]
    • 13673: D87513
      Homo sapiens mRNA for Grb7 protein, partial cds
      gi|1526534|dbj|D587513.1|D87513[1526534]
    • 13674: D49919
      Homo sapiens mRNA for C-C chemokine receptor type 2, complete cds
      gi|2626807|dbj|D549919.1|D49919[2626807]
    • 13675: AF030512
      Homo sapiens small cell vasopressin subtype 1b receptor mRNA, complete cds
      gi|2613124|gb|AF030512.1|AF030512[2613124]
    • 13676: Y12852
      Homo sapiens P2X7 gene, exon 2 and 3
      gi|2612788|emb|Y12852.1|HSP2X7E23[2612788]
    • 13677: Y12851
      Homo sapiens P2X7 gene, exon 1 and joined CDS
      gi|2597926|emb|Y12851.1|HSP2X7EX1[2597926]
    • 13678: Y12854
      Homo sapiens P2X7 gene, exon 9-11
      gi|2612787|emb|Y12854.1|HSP2X7911[2612787]
    • 13679: Y12853
      Homo sapiens P2X7 gene, exon 4-8
      gi|2612786|emb|Y12853.1|HSP2X748[2612786]
    • 13680: Y12855
      Homo sapiens P2X7 gene, exon 12 and 13
      gi|2612785|emb|Y12855.1|HSP2X7123[2612785]
    • 13681: AB005520
      Homo sapiens ppar gamma2 gene for peroxisome proliferator activated-receptor gamma, partial cds and 5′ flanking
      gi|2605488|dbj|AB005520.1|AB005520[2605488]
    • 13682: Y09765
      Homo sapiens mRNA for putative GABA receptor epsilon subunit
      gi|2285960|emb|Y09765.1|HSY09765[2285960]
    • 13683: Y09764
      Homo sapiens GABRE gene, exon 2-8
      gi|2285959|emb|Y09764.1|HSY09764[2285959]
    • 13684: Y09763
      Homo sapiens GABRE gene, exon 1 (and joined CDS)
      gi|2285957|emb|Y09763.1|HSY09763[2285957]
    • 13685: AF026535
      Homo sapiens chemokine receptor (CCR3) mRNA, complete cds
      gi|2582565|gb|AF026535.1|AF026535[2582565]
    • 13686: AF026071
      Homo sapiens soluble death receptor 3 beta (DR3) mRNA, complete cds
      gi|2570832|gb|AF026071.1|AF026071[2570832]
    • 13687: AF022956
      Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds
      gi|2570532|gb|AF022956.1|AF022956[2570532]
    • 13688: AF022955
      Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds
      gi|2570530|gb|AF022955.1|AF022955[2570530]
    • 13689: AF022954
      Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds
      gi|2570528|gb|AF022954.1|AF022954[2570528]
    • 13690: AF022953
      Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds
      gi|2570526|gb|AF022953.1|AF022953[2570526]
    • 13691: AF014958
      Homo sapiens chemokine receptor X (CKRX) mRNA, complete cds
      gi|2305263|gb|AF014958.1|AF014958[2305263]
    • 13692: AB000712
      Homo sapiens hCPE-R mRNA for CPE-receptor, complete cds
      gi|2570124|dbj|AB000712.1|AB000712[2570124]
    • 13693: X94609
      H. sapiens mRNA for activatory NK receptor/KKA3 p50.3
      gi|1495414|emb|X94609.1HSANKRMR[1495414]
    • 13694: AF025375
      Homo sapiens chemokine receptor-4 (CXCR4) mRNA, complete cds
      gi|2565335|gb|AF025375.1|AF025375[2565335]
    • 13695: AF000380
      Homo sapiens folate binding protein mRNA, complete cds
      gi|2565193|gb|AF000380.1|HSAF000380[2565193]
    • 13696: U35875
      Homo sapiens B2 bradykinin receptor mRNA, 5′ sequence
      gi|1353391|gb|U35875.1|HSU35875[1353391]
    • 13697: AF010193
      Homo sapiens MAD-related gene SMAD7 (SMAD7) mRNA, complete cds
      gi|2252821|gb|AF010193.1|AF010193[2252821]
    • 13698: X94634
      H. sapiens CD97 gene exon 7
      gi|1165087|emb|X94634.1|HSX94634[1165087]
    • 13699: X94633
      H. sapiens CD97 gene exon 4
      gi|1165086|emb|X94633.1|HSX94633[1165086]
    • 13700: X94632
      H. sapiens CD97 gene exon 3
      gi|1165085|emb|X94632.1|HSX94632[1165085]
    • 13702: AF007892
      Homo sapiens P2Y6 receptor, long splice variant mRNA, complete cds
      gi|2258421|gb|AF007892.1|[2258421]
    • 13703: AF007891
      Homo sapiens P2Y6 receptor, short splice variant mRNA, complete cds
      gi|2258419|gb|AF007891.1|[2258419]
    • 13704: AF022383
      Homo sapiens complexin I mRNA, complete cds
      gi|2465458|gb|AF022383.1|AF022383[2465458]
    • 13709: X89860
      H. sapiens mRNA for T-cell receptor alpha chain
      gi|927420|emb|X89860.1|HSNP7TCR2[927420]
    • 13710: Y08456
      H. sapiens ChemR1 gene
      gi|2465081|emb|Y08456.1|HSCHEMR1[2465081]
    • 13711: U95025
      Homo sapiens metabotropic glutamate receptor 8 (GRM8) mRNA, complete cds
      gi|2435409|gb|U95025.1|HSU95025[2435409]
    • 13712: AF021799
      Homo sapiens interleukin 17 receptor-like mRNA sequence
      gi|2460201|gb|AF021799.1|AF021799[2460201]
    • 13714: U73443
      Homo sapiens 5HT3 serotonin receptor gene, partial cds
      gi|2459549|gb|U73443.1|MMU73443[2459549]
    • 13715: AB000520
      Homo sapiens mRNA for APS, complete cds
      gi|2447035|dbj|AB000520.1|AB000520[2447035]
    • 13716: X98172
      H. sapiens mRNA for MACH-alpha-1 protein
      gi|1403318|emb|X98172.1|HSMACHA1[1403318]
    • 13728: AH005567
      Homo sapiens chromosome 4 map 4q13
      gi|2290767|gb|AH005567.1|SEG_HSGNRHR[2290767]
    • 13729: AF001952
      Homo sapiens gonadotropin releasing hormone receptor (GNRHR) gene, exon 3 and complete cds
      gi|2290766|gb|AF001952.1|HSGNRHR3[2290766]
    • 13730: AF001951
      Homo sapiens gonadotropin releasing hormone receptor (GNRHR) gene, exon 2
      gi|2290765|gb|AF001951.1|HSGNRHR2[2290765]
    • 13731: AF001950
      Homo sapiens gonadotropin releasing hormone receptor (GNRHR) gene, exon 1
      gi|2290764|gb|AF001950.1|HSGNRHR1[2290764]
    • 13733: AF020201
      Homo sapiens Jagged 2 mRNA, complete cds
      gi|2432001|gb|AF020201.1|AF020201([2432001]
    • 13734: Y14442
      Homo sapiens mRNA for olfactory receptor protein, partial
      gi|2370144|emb|Y14442.1|HSOLFMF[2370144]
    • 13736: AF017061
      Homo sapiens vasopressin-activated calcium mobilizing putative receptor protein
      (VACM-1) mRNA, complete cds
      gi|2394273|gb|AF017061.1|AF017061[2394273]
    • 13737: AF017262
      Homo sapiens putative G protein-coupled receptor mRNA, complete cds
      gi|2388705|gb|AF017262.1|AF017262[2388705]
    • 13738: AF016917
      Homo sapiens GABA-A receptor delta subunit (GABRD) mRNA, complete cds
      gi|2388692|gb|AF016917.1|AF016917[2388692]
    • 13739: Y13248
      Homo sapiens mRNA for orphan chemokine receptor TYMSTR
      gi|2370179|emb|Y13248.1|HSY13248[2370179]
    • 13740: D83492
      Homo sapiens mRNA for Eph-family protein, complete cds
      gi|2281007|dbj|D83492.1|D83492[2281007]
    • 13741: AB002058
      Homo sapiens mRNA for HUMAN P2XM, complete cds
      gi|2350846|dbj|AB002058.1|AB002058[2350846]
    • 13742: AF015251
      Homo sapiens breast cancer-related unknown protein mRNA, partial cds
      gi|2345090|gb|AF015251.1|AF015251[2345090]
    • 13743: AF004231
      Homo sapiens monocyte/macrophage Ig-related receptor MIR-10 (MIR cl-10) mRNA, complete cds
      gi|2343110|gb|AF004231.1|AF004231[2343110]
    • 13744: AF004230
      Homo sapiens monocyte/macrophage Ig-related receptor MIR-7 (MIR cl-7) mRNA, complete cds
      gi|2343108|gb|AF004230.1|AF004230[2343108]
    • 13745: X90563
      H. sapiens mRNA for peroxisome proliferactor activated receptor gamma
      gi|1480099|emb|X90563.1|HSPPARGAM[1480099]
    • 13746: AF012629
      Homo sapiens antagonist decoy receptor for TRAIL/Apo-2L (TRID) mRNA, complete cds
      gi|2338430|gb|AF012629.1|AF012629[2338430]
    • 13747: AF012628
      Homo sapiens death domain containing receptor for TRAIL/Apo-2L (DR5) mRNA, complete cds
      gi|2338428|gb|AF012628.1|AF012628[2338428]
    • 13748: AF012536
      Homo sapiens decoy receptor 1 (DcR1) mRNA, complete cds
      gi|2338421|gb|AF012536.1|AF012536[2338421]
    • 13749: AF012535
      Homo sapiens death receptor 5 (DR5) mRNA, complete cds
      gi|2338419|gb|AF012535.1|AF012535[2338419]
    • 13750: AF012903
      Homo sapiens P2X4 ATP-gated cation channel protein mRNA, partial cds
      gi|2331043|gb|AF012903.1|AF012903[2331043]
    • 13751: X69316
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 21
      gi|34105|emb|X69316.1|HSKITPO16[34105]
    • 13752: X69315
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exons 18, 19, 20
      gi|34104|emb|X69315.1|HSKITPO15[34104]
    • 13753: X69314
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 17
      gi|34103|emb|X69314.1|HSKITPO14[34103]
    • 13754: X69313
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 16
      gi|34102|emb|X69313.1|HSKITPO13[34102]
    • 13755: X69312
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 15
      gi|34101|emb|X69312.1|HSKITPO12[34101]
    • 13756: X69311
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 14
      gi|34100|emb|X69311.1|HSKITPO11[34100]
    • 13757: X69310
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exons 10, 11, 12, 13
      gi|34099|emb|X69310.1|HSKITPO10[34099]
    • 13758: X69309
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 9
      gi|34098|emb|X69309.1|HSKITPO09[34098]
    • 13759: X69308
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 8
      gi|34097|emb|X69308.1|HSKITPO08[34097]
    • 13760: X69307
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 7
      gi|34096|emb|X69307.1|HSKITPO07[34096]
    • 13761: X69306
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 6
      gi|34095|emboX69306.1|HSKITPO06[34095]
    • 13762: X69305
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 5
      gi|34094|emb|X69305.1|HSKITPO05[34094]
    • 13763: AF005419
      Homo sapiens P2Y5-like receptor gene, complete cds
      gi|2240034|gb|AF005419.1|AF005419[2240034]
    • 13764: L42324
      Homo sapiens (clone GPCR W) G protein-linked receptor gene (GPCR) gene, 5′ end
      of cds
      gi|066730|gb|L42324.1|HUMFRCG[1066730]
    • 13766: AF015910
      Homo sapiens unknown protein mRNA, partial cds
      gi|2286201|gb|AF015910.1|AF015910[2286201]
    • 13767: X99250
      H. sapiens mRNA for endothelin-B receptor splice variant
      gi|2285955|emb|X99250.1|HSX99250[2285955]
    • 13768: AF007545
      Homo sapiens SIV/HIV receptor Bonzo (Bonzo) mRNA, complete cds
      gi|225342|gb|AF007545.1|AF007545[2253421]
    • 13769: Z79783
      H. sapiens G protein-coupled receptor CKR-L2
      gi|2281709|emb|Z79783.1|HSCKRL2[2281709]
    • 13778: Z49994
      H. sapiens partial gene for proteinase-activated receptor 2 (1289 BP)
      gi|1008086|emb|Z49994.1|HSPAR2B[1008086]
    • 13779: AF007555
      Homo sapiens IAR/receptor-like protein-tyrosine phosphatase precursor mRNA, complete cds
      gi|2262074|gb|AF007555.1|AF007555[2262074]
    • 13780: AF008556
      Homo sapiens interleukin-2 receptor mRNA, alternatively spliced, partial cds
      gi|2266932|gb|AF008556.1|AF008556[2266932]
    • 13891: Y10152
      H. sapiens mRNA for CRF2 receptor, beta isoform, aberrantly spliced, (94 bp deletion)
      gi|1785640|emb|Y10152.1|HSCRF294[1785640]
    • 13892: Y10153
      H. sapiens mRNA for CRF2 receptor, beta isoform, aberrantly spliced, (227 bp insertion)
      gi|1785639|emb|Y10153.1|HSCRF2227[1785639]
    • 13893: Y10151
      H. sapiens mRNA for CRF2 receptor, beta isoform, partial
      gi|1785637|emb|Y10151.1|HSCRF2[1785637]
    • 13894: M17325
      Homo sapiens T-cell receptor gamma-chain constant region (TCRGC1) mRNA, partial
      cds
      gi|2072752|gb|M17325.1|HUMTCGCJ[2072752]
    • 13895: M17324
      Homo sapiens T-cell receptor gamma-chain constant region (TCRGC2) mRNA, partial
      cds
      gi|207275|gb|M17324.1|HUMTCGCI[2072751]
    • 13896: M17323
      Homo sapiens T-cell receptor gamma-chain constant region (TCRGC2) mRNA, partial
      cds
      gi|2072750|gb|M17323.1|HUMTCGCH[2072750]
    • 13897: AF004327
      Homo sapiens angiopoietin-2 mRNA, complete cds
      gi|2257932|gb|AF004327.1|AF004327[2257932]
    • 13898: AF004021
      Homo sapiens prostaglandin F2 alpha receptor mRNA, complete cds
      gi|2257849|gb|AF004021.1|AF004021[2257849]
    • 13899: AF006464
      Homo sapiens muscle specific tyrosine kinase receptor (MUSK) mRNA, complete cds
      gi|225331|gb|AF006464.1|AF006464[2253311]
    • 13900: AF005637
      Homo sapiens endothelin A receptor gene, 5′ flanking region and exon 1
      gi|2253289|gb|AF005637.1|AF005637[2253289]
    • 13902: Z24461
      H. sapiens MTCP-1 gene
      gi|406866|emb|Z24461.1|HSMTCP1I[406866]
    • 13903: Z24463
      H. sapiens MTCP-1 gene
      gi|406865|emb|Z24463.1|HSMTCP1H[406865]
    • 13904: Z24457
      H. sapiens of TCRA gene MTCP-1 gene
      gi|406860|emb|Z24457.1|HSMTCP1D[406860]
    • 13905: Z24456
      H. sapiens of MTCP-1 gene MTCP-1 gene
      gi|406859|emb|Z24456.1|HSMTCP1C[406859]
    • 13906: U45984
      Homo sapiens CCR6 chemokine receptor (CMKBR6) gene, complete cds
      gi|2246432|gb|U45984.1|HSU45984[2246432]
    • 13908: AF005900
      Homo sapiens alpha2B-adrenergic receptor (alpha2C2AR) gene, complete cds
      gi|2245627|gb|AF005900.1|AF005900[2245627]
    • 13909: AF005210
      Homo sapiens CC chemokine receptor CCR8 (CMKBR8) mRNA, partial cds
      gi|2245579|gb|AF005210.1|AF005210[2245579]
    • 13524: Y16282
      Homo sapiens mRNA for nicotinic acetylcholine receptor alpha6 subunit precursor
      gi|2815224|emb|Y16282.1|HSY16282[2815224]
    • 13525: Y16281
      Homo sapiens mRNA for nicotinic acetylcholine receptor alpha2 subunit precursor
      gi|2815222|emb|Y16281.1|HSY16281[2815222]
    • 13526: X98858
      H. sapiens mRNA for HLA-C specific activatory NK receptor
      gi|1419593|emb|X98858.1|HSNKREC[1419593]
    • 13527: M76676
      Homo sapiens leukocyte platelet-activating factor receptor mRNA, complete cds
      gi|2810988|gb|M76676.1|HUMNPIIY20[2810988]
    • 13528: Y08420
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha7 subunit precursor
      gi|2808623|emb|Y08420.1|HSNACHRA7[2808623]
    • 13529: Y08419
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha5 subunit precursor
      gi|1702913|emb|Y08419.1|HSNACHRA5[1702913]
    • 13530: Y08421
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha4 subunit precursor
      gi|1702911|emb|Y08421.1|HSNACHRA4[1702911]
    • 13531: Y08417
      H. sapiens mRNA for nicotinic acetylcholine receptor beta3 subunit precursor
      gi|1702909|emb|Y08417.1|HSNACHR3B[1702909]
    • 13532: Y08416
      H. sapiens mRNA for nicotinic acetylcholine receptor beta4 subunit precursor
      gi|1702919|emb|Y08416.1|HSNACHRB4[1702919]
    • 13533: Y08415
      H. sapiens mRNA for nicotinic acetylcholine receptor beta2 subunit precursor
      gi|1702917|emb|Y08415.1|HSNACHRB2[1702917]
    • 13534: Y08418
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha3 subunit precursor
      gi|1702907|emb|Y08418.1|HSNACHR3A[1702907]
    • 13535: AF001985
      Homo sapiens CD38 gene, 5′ upstream sequence
      gi|2804672|gb|AF001985.1|AF001985[2804672]
    • 13536: AF042077
      Homo sapiens olfactory receptor-like protein (OLFR 42B) gene, OLFR 42B-9079.6 allele, partial cds
      gi|2801710|gb|AF042077.1|AF042077[2801710]
    • 13537: AF042076
      Homo sapiens olfactory receptor-like protein (OLFR 42B) gene, OLFR 42B-9108.1 allele, partial cds
      gi|2801708|gb|AF042076.1|AF042076[2801708]
    • 13538: AF042075
      Homo sapiens olfactory receptor-like protein (OLFR 42B) gene, OLFR 42B-9110 allele, partial cds
      gi|2801706|gb|AF042075.1|AF042075[2801706]
    • 13539: AF042074
      Homo sapiens olfactory receptor-like protein (OLFR 42A) gene, OLFR 42A-9079.3 allele, partial cds
      gi|2801704|gb|AF042074.1|AF042074[2801704]
    • 13540: AF042073
      Homo sapiens olfactory receptor-like protein (OLFR 42A) gene, OLFR 42A-9049 allele, partial cds
      gi|2801702|gb|AF042073.1|AF042073[2801702]
    • 13600: Y10530
      H. sapiens gene encoding putative olfactory receptor (clone htpcr2)
      gi|2792017|emb|Y10530.1|HSHTPCR2[2792017]
    • 13601: Y10529
      H. sapiens mRNA for putative olfactory receptor (clone ht2)
      gi|2792015|emb|Y10529.1|HSHT2[2792015]
    • 13614: Z26876
      H. sapiens gene for ribosomal protein L38
      gi|407422|emb|Z26876.1|HSRPL38[407422]
    • 13615: Z50150
      H. sapiens mRNA for tyrosine kinase activator protein 1 (TKA-1)
      gi|1246762|emb|Z50150.1|HSTKA1MR[1246762]
    • 13616: Y13055
      Homo sapiens mRNA for NKG2-CII activating NK receptor
      gi|2765292|emb|Y13055.1|HSNKG2CII[2765292]
    • 13617: Y13054
      Homo sapiens mRNA for NK receptor, clone GR #29
      gi|2765290|emb|Y13054.1|HSNKREC29[2765290]
    • 13618: Y10437
      H. sapiens mRNA for serotonin receptor 4
      gi|2765076|emb|Y10437.1|HSSERR4[2765076]
    • 13619: AJ002105
      Homo sapiens mRNA for NK receptor, clone library TG14#13
      gi|2764706|emb|AJ002105.1|HSAJ2105[2764706]
    • 13620: AJ002104
      Homo sapiens mRNA for NK receptor, clone library TG14#6
      gi|2764704|emb|AJ002104.1|HSAJ2104[2764704]
    • 13621: AJ002103
      Homo sapiens mRNA for NK receptor, clone library TG14#35
      gi|2764702|emb|AJ002103.1|HSAJ2103[2764702]
    • 13622: AJ002102
      Homo sapiens mRNA for NK receptor, clone library TG14#8
      gi|2764700|emb|AJ002102.1|HSAJ2102[2764700]
    • 13623: AJ000001
      Homo sapiens mRNA for CD94-B NK receptor
      gi|2764393|emb|AJ000001.1|HSCD94B[2764393]
    • 13624: Y10141
      H. sapiens DAT1 gene, partial, VNTR
      gi|1752665|emb|Y10141.1|HSDAT1[1752665]
    • 13625: Z97213
      Homo sapiens mRNA for T-cell receptor
      gi|2239129|emb|Z97213.1|HSTCRBV2S[2239129]
    • 13627: AF026263
      Homo sapiens muscarinic receptor (CHRM5) mRNA, complete cds
      gi|2605721|gb|AF026263.1|AF026263[2605721]
    • 13628: AF026261
      Homo sapiens histamine H1 receptor mRNA, complete cds
      gi|2605717|gb|AF026261.1|AF026261[2605717]
    • 13629: AF026260
      Homo sapiens vitamin D receptor (VDR) mRNA, complete cds
      gi|2605715|gb|AF026260.1|AF026260[2605715]
    • 13630: AH005786
      Homo sapiens CC chemokine receptor 5 (CCR5) gene, complete cds
      gi|2739498|gb|AH005786.1|SEG_HSCCR5AB[2739498]
    • 13631: AF031237
      Homo sapiens CC chemokine receptor 5 (CCR5) gene, complete cds
      gi|2739497|gb|AF031237.1|HSCCR5AB3[2739497]
    • 13633: AH005782
      Homo sapiens chromosome X map Xq28
      gi|2735348|gb|AH005782.1|SEG_HSGABRE[2735348]
    • 13634: AF037334
      Homo sapiens Eph-like receptor tyrosine kinase hEphB1d (EphB1) mRNA, complete cds
      gi|2739209|gb|AF037334.1|AF037334[2739209]
    • 13635: AF037333
      Homo sapiens Eph-like receptor tyrosine kinase hEphB1c (EphB1) mRNA, complete cds
      gi|2739207|gb|AF037333.1|AF037333[2739207]
    • 13636: AF011406
      Homo sapiens corticotropin releasing hormone receptor type 2 beta isoform (CRH2R) mRNA, complete cds
      gi|2738557|gb|AF011406.1|AF011406[2738557]
    • 13637: U59632
      Homo sapiens H5 mRNA, partial cds; and platelet glycoprotein Ib beta chain mRNA,
      complete cds
      gi|1809264|gb|U59632.1|HSU59632[1809264]
    • 13638: D86864
      Homo sapiens mRNA for acetyl LDL receptor, complete cds
      gi|2723468|dbj|D86864.1|D86864[2723468]
    • 13639: AF027208
      Homo sapiens AC133 antigen mRNA, complete cds
      gi|2688948|gb|AF027208.1|AF027208[2688948]
    • 13640: AB001025
      Homo sapiens mRNA for brain ryanodine receptor, complete cds
      gi|2696014|dbj|AB001025.1|AB001025[2696014]
    • 13641: D00017
      Homo sapiens mRNA for lipocortin II, complete cds
      gi|219909|dbj|D00017.1|HUMLIC[219909]
    • 13644: AF025998
      Homo sapiens atrial natriuretic peptide clearance receptor (ANPRC) mRNA, complete cds
      gi|257085|gb|AF025998.1|AF025998[2570851]
    • 13645: AD000671
      Homo sapiens DNA from chromosome 19-cosmid f24109 containing HRX2, genomic sequence
      gi|1905893|gb|AD000671.1|AD000671[1905893]
    • 13646: Z49119
      H. sapiens mRNA for serotonin 6 receptor (5-HT6; partial)
      gi|984128|emb|Z49119.1|HS5HT6[984128]
    • 13647: Z48150
      H. sapiens 5-HT4 mRNA for serotonin 4 receptor (5-HT4)
      gi|984126|emb|Z48150.1|HS5HT4[984126]
    • 13648: Y15743
      Homo sapiens RET proto-oncogene, exon 13 containing two mutations
      gi|2665353|emb|Y15743.1|HSRET13[2665353]
    • 13649: AF000575
      Homo sapiens clone 16 immunoglobulin-like transcript 5 mRNA, complete cds
      gi|2264428|gb|AF000575.1|AF000575[2264428]
    • 13650: AF000574
      Homo sapiens clone 1 immunoglobulin-like transcript 4 mRNA, complete cds
      gi|2264426|gb|AF000574.1|AF000574[2264426]
    • 13651: Z26652
      H. sapiens FLT3 mRNA for FLT3 receptor tyrosine kinase
      gi|406322|emb|Z26652.1|HSFLT3RTK[406322]
    • 13653: X82208
      H. sapiens mRNA for beta-centractin (ATCC# HHCPJ76)
      gi|563887|emb|X82208.1|HSBCENTR[563887]
    • 13654: AF035261
      Homo sapiens thyroid stimulating hormone receptor (TSHR) mRNA, partial cds
      gi|2654195|gb|AF035261.1|HSTSHR[2654195]
    • 13655: AF032388
      Homo sapiens vasopressin receptor type 2 mRNA, alternatively spliced, complete
      cds
      gi|2654030|gb|AF032388.1|AF032388[2654030]
    • 13656: AF025534
      Homo sapiens leucocyte immunoglobulin-like receptor-8 (LIR-8) mRNA, complete cds
      gi|2653874|gb|AF025534.1|AF025534[2653874]
    • 13657: AF025533
      Homo sapiens leucocyte immunoglobulin-like receptor-3 (LIR-3) mRNA, complete cds
      gi|2653872|gb|AF025533.1|AF025533[2653872]
    • 13658: AF025532
      Homo sapiens leucocyte immunoglobulin-like receptor-5 (LIR-5) mRNA, complete cds
      gi|2653870|gb|AF025532.1|AF025532[2653870]
    • 13659: AF025531
      Homo sapiens leucocyte immunoglobulin-like receptor-7 (LIR-7) mRNA, complete cds
      gi|2653868|gb|AF025531.1|AF025531[2653868]
    • 13660: AF025530
      Homo sapiens leucocyte immunoglobulin-like receptor-6a (LIR-6) mRNA, complete cds
      gi|2653866|gb|AF025530.1|AF025530[2653866]
    • 13661: AF025529
      Homo sapiens leucocyte immunoglobulin-like receptor-6b (LIR-6) mRNA, complete cds
      gi|2653864|gb|AF025529.1|AF025529[2653864]
    • 13662: AF025528
      Homo sapiens leucocyte immunoglobulin-like receptor-2 (LIR-2) mRNA, complete cds
      gi|2653862|gb|AF025528.1|AF025528[2653862]
    • 13663: AF025527
      Homo sapiens leucocyte immunoglobulin-like receptor-4 (LIR-4) mRNA, complete cds
      gi|2653860|gb|AF025527.1|AF025527[2653860]
    • 13664: Y13583
      Homo sapiens mRNA for G-protein coupled receptor
      gi|255233|emb|Y13583.1|HSGPCP[2652933]
    • 13665: Y13367
      H. sapiens mRNA for phosphoinositide 3-kinase
      gi|2143259|emb|Y13367.1|HSPHOSI3K[2143259]
    • 13666: X82207
      H. sapiens mRNA for beta-centractin (PC3)
      gi|563885|emb|X82207.1|HSBCENT[563885]
    • 13667: AF033854
      Homo sapiens lymphocyte inhibitor of TRAIL (LIT) mRNA, complete cds
      gi|2645841|gb|AF033854.1|AF033854[2645841]
    • 13668: X81882
      H. sapiens mRNA for for vasopressin activated calcium mobilizing receptor-like protein
      gi|1628414|emb|X81882.1|HSVACM1[1628414]
    • 13669: AF024690
      Homo sapiens putative G protein-coupled receptor (GPR43) gene, complete cds
      gi|2612951|gb|AF024690.1|AF024690[2612951]
    • 13670: AF024689
      Homo sapiens putative G protein-coupled receptor (GPR42) gene, complete cds
      gi|2612949|gb|AF024689.1|AF024689[2612949]
    • 13671: AF024688
      Homo sapiens putative G protein-coupled receptor (GPR41) gene, complete cds
      gi|2612947|gb|AF024688.1|AF024688[2612947]
    • 13672: AF024687
      Homo sapiens putative G protein-coupled receptor (GPR40) gene, complete cds
      gi|2612945|gb|AF024687.1|AF024687[2612945]
    • 13673: D87513
      Homo sapiens mRNA for Grb7 protein, partial cds
      gi|1526534|dbj|D87513.1|D87513[1526534]
    • 13674: D49919
      Homo sapiens mRNA for C-C chemokine receptor type 2, complete cds
      gi|2626807|dbj|D49919.1|D49919[2626807]
    • 13675: AF030512
      Homo sapiens small cell vasopressin subtype 1b receptor mRNA, complete cds
      gi|2613124|gb|AF030512.1|AF030512[2613124]
    • 13676: Y12852
      Homo sapiens P2X7 gene, exon 2 and 3
      gi|2612788|emb|Y12852.1|HSP2X7E23[2612788]
    • 13677: Y12851
      Homo sapiens P2X7 gene, exon 1 and joined CDS
      gi|2597926|emb|Y12851.1|HSP2X7EX1[2597926]
    • 13678: Y12854
      Homo sapiens P2X7 gene, exon 9-11
      gi|2612787|emb|Y12854.1|HSP2X7911[2612787]
    • 13679: Y12853
      Homo sapiens P2X7 gene, exon 4-8
      gi|2612786|emb|Y12853.1|HSP2X748[2612786]
    • 13680: Y12855
      Homo sapiens P2X7 gene, exon 12 and 13
      gi|2612785|emb|Y112855.1|HSP2X7123[2612785]
    • 13681: AB005520
      Homo sapiens ppar gamma2 gene for peroxisome proliferator activated-receptor gamma, partial cds and 5′ flanking
      gi|2605488|dbj|AB005520.1|AB005520[2605488]
    • 13682: Y09765
      Homo sapiens mRNA for putative GABA receptor epsilon subunit
      gi|2285960|emb|Y09765.1|HSY09765[2285960]
    • 13683: Y09764
      Homo sapiens GABRE gene, exon 2-8
      gi|2285959|emb|Y09764.1|HSY09764[2285959]
    • 13684: Y09763
      Homo sapiens GABRE gene, exon 1 (and joined CDS)
      gi|2285957|emb|Y09763.1|HSY09763[2285957]
    • 13685: AF026535
      Homo sapiens chemokine receptor (CCR3) mRNA, complete cds
      gi|2582565|gb|AF026535.1|AF026535[2582565]
    • 13686: AF026071
      Homo sapiens soluble death receptor 3 beta (DR3) mRNA, complete cds
      gi|2570832|gb|AF026071.1|AF026071[2570832]
    • 13687: AF022956
      Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds
      gi|2570532|gb|AF022956.1|AF022956[2570532]
    • 13688: AF022955
      Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds
      gi|2570530|gb|AF022955.1|AF022955[2570530]
    • 13689: AF022954
      Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds
      gi|2570528|gb|AF022954.1|AF022954[2570528]
    • 13690: AF022953
      Homo sapiens beta2-adrenergic receptor (ADRB2) gene, complete cds
      gi|2570526|gb|AF022953.1|AF022953[2570526]
    • 13691: AF014958
      Homo sapiens chemokine receptor X (CKRX) mRNA, complete cds
      gi|2305263|gb|AF014958.1|AF014958[2305263]
    • 13692: AB000712
      Homo sapiens hCPE-R mRNA for CPE-receptor, complete cds
      gi|2570124|dbj|AB000712.1|AB000712[2570124]
    • 13693: X94609
      H. sapiens mRNA for activatory NK receptor/KKA3 p50.3
      gi|1495414|emb|X94609.1|HSANKRMR[1495414]
    • 13694: AF025375
      Homo sapiens chemokine receptor-4 (CXCR4) mRNA, complete cds
      gi|2565335|gb|AF025375.1|AF025375[2565335]
    • 13695: AF000380
      Homo sapiens folate binding protein mRNA, complete cds
      gi|2565193|gb|AF000380.1|HSAF000380[2565193]
    • 13696: U35875
      Homo sapiens B2 bradykinin receptor mRNA, 5′ sequence
      gi|135339|gb|U35875.1|HSU35875[1353391]
    • 13697: AF010193
      Homo sapiens MAD-related gene SMAD7 (SMAD7) mRNA, complete cds
      gi|225282|gb|AF010193.1|AF010193[2252821]
    • 13698: X94634
      H. sapiens CD97 gene exon 7
      gi|1165087|emb|X94634.1|HSX94634[1165087]
    • 13699: X94633
      H. sapiens CD97 gene exon 4
      gi|1165086|emb|X94633.1|HSX94633[1165086]
    • 13700: X94632
      H. sapiens CD97 gene exon 3
      gi|1165085|emb|X94632.1|HSX94632[1165085]
    • 13702: AF007892
      Homo sapiens P2Y6 receptor, long splice variant mRNA, complete cds
      gi|225842|gb|AF007892.1|[2258421]
    • 13703: AF007891
      Homo sapiens P2Y6 receptor, short splice variant mRNA, complete cds
      gi|2258419|gb|AF007891.1|[2258419]
    • 13704: AF022383
      Homo sapiens complexin I mRNA, complete cds
      gi|2465458|gb|AF022383.1|AF022383[2465458]
    • 13709: X89860
      H. sapiens mRNA for T-cell receptor alpha chain
      gi|927420|emb|X89860.1|HSNP7TCR2[927420]
    • 13710: Y08456
      H. sapiens ChemR1 gene
      gi|2465081|emb|Y08456.1|HSCHEMR1[2465081]
    • 13711: U95025
      Homo sapiens metabotropic glutamate receptor 8 (GRM8) mRNA, complete cds
      gi|2435409|gb|U95025.1|HsU95025[2435409]
    • 13712: AF021799
      Homo sapiens interleukin 17 receptor-like mRNA sequence
      gi|2460201|gb|AF021799.1|AF021799[2460201]
    • 13714: U73443
      Homo sapiens 5HT3 serotonin receptor gene, partial cds
      gi|2459549|gb|U73443.1|MMU73443[2459549]
    • 13715: AB000520
      Homo sapiens mRNA for APS, complete cds
      gi|2447035|dbj|AB3000520.1|AB3000520[2447035]
    • 13716: X98172
      H. sapiens mRNA for MACH-alpha-1 protein
      gi|1403318|emb|X98172.1|HSMACHA1[1403318]
    • 13727: X92883
      H. sapiens mRNA for T cell receptor alpha (clone XPHC46IV)
      gi|1061141|emb|X92883.1|HSPHC46A1[1061141]
    • 13728: AH005567
      Homo sapiens chromosome 4 map 4q13
      gi|2290767|gb|AH005567.1|SEG_HSGNRHR[2290767]
    • 13729: AF001952
      Homo sapiens gonadotropin releasing hormone receptor (GNRHR) gene, exon 3 and complete cds
      gi|2290766|gb|AF001952.1|HSGNRHR3[2290766]
    • 13730: AF001951
      Homo sapiens gonadotropin releasing hormone receptor (GNRHR) gene, exon 2
      gi|2290765|gb|AF001951.1|HSGNRHR2[2290765]
    • 13731: AF001950
      Homo sapiens gonadotropin releasing hormone receptor (GNRHR) gene, exon 1
      gi|2290764|gb|AF001951.1|HSGNRHR1[2290764]
    • 13732: AF017263
      Homo sapiens putative G protein-coupled receptor gene, partial intron sequence
      gi|2435439|gb|AF017263.1|AF017263[2435439]
    • 13733: AF020201
      Homo sapiens Jagged 2 mRNA, complete cds
      gi|2432001|gb|AF020201.1|AF020201[2432001]
    • 13734: Y14442
      Homo sapiens mRNA for olfactory receptor protein, partial
      gi|2370144|emb|Y14442.1|HSOLFMF[2370144]
    • 13735: AF017264
      Homo sapiens putative G protein-coupled receptor gene, intronic sequence
      gi|2407224|gb|AF017264.1|AF017264[2407224]
    • 13736: AF017061
      Homo sapiens vasopressin-activated calcium mobilizing putative receptor protein
      (VACM-1) mRNA, complete cds
      gi|2394273|gb|AF01706.1|AF017061[2394273]
    • 13737: AF017262
      Homo sapiens putative G protein-coupled receptor mRNA, complete cds
      gi|2388705|gb|AF017262.1|AF017262[2388705]
    • 13738: AF016917
      Homo sapiens GABA-A receptor delta subunit (GABRD) mRNA, complete cds
      gi|2388692|gb|AF016917.1|AF016917[2388692]
    • 13739: Y13248
      Homo sapiens mRNA for orphan chemokine receptor TYMSTR
      gi|2370179|emb|Y13248.1|HSY13248[2370179]
    • 13740: D83492
      Homo sapiens mRNA for Eph-family protein, complete cds
      gi|2281007|dbj|D83492.1|D83492[2281007]
    • 13741: AB002058
      Homo sapiens mRNA for HUMAN P2XM, complete cds
      gi|2350846|dbj|AB002058.1|AB002058[2350846]
    • 13742: AF015251
      Homo sapiens breast cancer-related unknown protein mRNA, partial cds
      gi|2345090|gb|AF015251.1|AF015251[2345090]
    • 13743: AF004231
      Homo sapiens monocyte/macrophage Ig-related receptor MIR-10 (MIR cl-10) mRNA, complete cds
      gi|2343110|gb|AF004231.1|AF004231[2343110]
    • 13744: AF004230
      Homo sapiens monocyte/macrophage Ig-related receptor MIR-7 (MIR cl-7) mRNA, complete cds
      gi|2343108|gb|AF004230.1|AF004230[2343108]
    • 13745: X90563
      H. sapiens mRNA for peroxisome proliferactor activated receptor gamma
      gi|1480099|emb|X90563.1|HSPPARGAM[1480099]
    • 13746: AF012629
      Homo sapiens antagonist decoy receptor for TRAIL/Apo-2L (TRID) mRNA, complete cds
      gi|2338430|gb|AF012629.1|AF012629[2338430]
    • 13747: AF012628
      Homo sapiens death domain containing receptor for TRAIL/Apo-2L (DR5) mRNA, complete cds
      gi|2338428|gb|AF012628.1|AF012628[2338428]
    • 13748: AF012536
      Homo sapiens decoy receptor 1 (DcR1) mRNA, complete cds
      gi|2338421|gb|AF012536.1|AF012536[2338421]
    • 13749: AF012535
      Homo sapiens death receptor 5 (DR5) mRNA, complete cds
      gi|2338419|gb|AF012535.1|AF012535[2338419]
    • 13750: AF012903
      Homo sapiens P2X4 ATP-gated cation channel protein mRNA, partial cds
      gi|2331043|gb|AF012903.1|AF012903[2331043]
    • 13751: X69316
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 21
      gi|34105|emb|X69316.1|HSKITPO16[34105]
    • 13752: X69315
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exons 18, 19, 20
      gi|34104|emb|X69315.1|HSKITPO15[34104]
    • 13753: X69314
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 17
      gi|34103|emb|X69314.1|HSKITPO14[34103]
    • 13754: X69313
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 16
      gi|34102|emb|X69313.1|HSKITPO13[34102]
    • 13755: X69312
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 15
      gi|34101|emb|X69312.1|HSKITPO12[34101]
    • 13756: X69311
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 14
      gi|34100|emb|X69311.1|HSKITPO11[34100]
    • 13757: X69310
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exons 10, 11, 12, 13
      gi|34099|emb|X69310.1|HSKITPO10[34099]
    • 13758: X69309
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 9
      gi|34098|emb|X69309.1|HSKITPO09[34098]
    • 13759: X69308
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 9
      gi|34097|emb|X69308.1|HSKITPO08[34097]
    • 13760: X69307
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 8
      gi|34096|emb|X69307.1|HSKITPO07[34096]
    • 13761: X69306
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 7
      gi|34095|emb|X69306.1|HSKITPO06[34095]
    • 13762: X69305
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 5
      gi|34094|emb|X69305.1|HSKITPO05[34094]
    • 13763: AF005419
      Homo sapiens P2Y5-like receptor gene, complete cds
      gi|2240034|gb|AF005419.1|AF005419[2240034]
    • 13764: L42324
      Homo sapiens (clone GPCR W) G protein-linked receptor gene (GPCR) gene, 5′ end
      of cds
      gi|1066730|gb|L42324.1|HUMFRCG[1066730]
    • 13766: AF015910
      Homo sapiens unknown protein mRNA, partial cds
      gi|2286201|gb|AF015910.1|AF015910[2286201]
    • 13767: X99250
      H. sapiens mRNA for endothelin-B receptor splice variant
      gi|2285955|emb|X99250.1|HSX99250[2285955]
    • 13768: AF007545
      Homo sapiens SIV/HIV receptor Bonzo (Bonzo) mRNA, complete cds
      gi|225342|gb|AF007545.1|AF007545[2253421]
    • 13769: Z79783
      H. sapiens G protein-coupled receptor CKR-L2
      gi|2281709|emb|Z79783.1|HSCKRL2[2281709]
    • 13778: Z49994
      H. sapiens partial gene for proteinase-activated receptor 2 (1289 BP)
      gi|1008086|emb|Z49994.1|HSPAR2B[1008086]
    • 13779: AF007555
      Homo sapiens IAR/receptor-like protein-tyrosine phosphatase precursor mRNA, complete cds
      gi|2262074|gb|AF007555.1|AF007555[2262074]
    • 13780: AF008556
      Homo sapiens interleukin-2 receptor mRNA, alternatively spliced, partial cds
      gi|2266932|gb|AF008556.1|AF008556[2266932]
    • 13891: Y10152
      H. sapiens mRNA for CRF2 receptor, beta isoform, aberrantly spliced, (94 bp deletion)
      gi|1785640|emb|Y10152.1|HSCRF294[1785640]
    • 13892: Y10153
      H. sapiens mRNA for CRF2 receptor, beta isoform, aberrantly spliced, (227 bp insertion)
      gi|1785639|emb|Y10153.1|HSCRF2227[1785639]
    • 13893: Y10151
      H. sapiens mRNA for CRF2 receptor, beta isoform, partial
      gi|1785637|emb|Y10151.1|HSCRF2[1785637]
    • 13894: M17325
      Homo sapiens T-cell receptor gamma-chain constant region (TCRGC1) mRNA, partial
      cds
      gi|2072752|gb|M17325.1|HUMTCGCJ[2072752]
    • 13895: M17324
      Homo sapiens T-cell receptor gamma-chain constant region (TCRGC2) mRNA, partial
      cds
      gi|2072751|gb|M17324.1|HUMTCGCI[2072751]
    • 13896: M17323
      Homo sapiens T-cell receptor gamma-chain constant region (TCRGC2) mRNA, partial
      cds
      gi|2072750|gb|M17323.1|HUMTCGCH[2072750]
    • 13897: AF004327
      Homo sapiens angiopoietin-2 mRNA, complete cds
      gi|2257932|gb|AF004327.1|AF004327[2257932]
    • 13898: AF004021
      Homo sapiens prostaglandin F2 alpha receptor mRNA, complete cds
      gi|2257849|gb|AF004021.1|AF004021[2257849]
    • 13899: AF006464
      Homo sapiens muscle specific tyrosine kinase receptor (MUSK) mRNA, complete cds
      gi|2253311|gb|AF006464.1|AF006464[2253311]
    • 13900: AF005637
      Homo sapiens endothelin A receptor gene, 5′ flanking region and exon 1
      gi|2253289|gb|AF005637.1|AF005637[2253289]
    • 13902: Z24461
      H. sapiens MTCP-1 gene
      gi|406866|emb|Z24461.1|HSMTCP1I[406866]
    • 13903: Z24463
      H. sapiens MTCP-1 gene
      gi|406865|emb|Z24463.1|HSMTCP1H[406865]
    • 13904: Z24457
      H. sapiens of TCRA gene MTCP-1 gene
      gi|406860|emb|Z24457.1|HSMTCP1D[406860]
    • 13905: Z24456
      H. sapiens of MTCP-1 gene MTCP-1 gene
      gi|406859|emb|Z24456.1|HSMTCP1C[406859]
    • 13906: U45984
      Homo sapiens CCR6 chemokine receptor (CMKBR6) gene, complete cds
      gi|2246432|gb|U45984.1|HSU45984[2246432]
    • 13908: AF005900
      Homo sapiens alpha2B-adrenergic receptor (alpha2C2AR) gene, complete cds
      gi|2245627|gb|AF005900.1|AF005900[2245627]
    • 13909: AF005210
      Homo sapiens CC chemokine receptor CCR8 (CMKBR8) mRNA, partial cds
      gi|2245579|gb|AF005210.1|AF005210[2245579]
    • 14010: Y13758
      Homo sapiens mRNA for transient receptor potential related channel 3 protein
      gi|2225936|emb|Y13758.1|HSY13758[2225936]
    • 14012: AF000546
      Homo sapiens purinergic receptor P2Y5 mRNA, complete cds
      gi|2232068|gb|AF000546.1|HSAF000546[2232068]
    • 14013: U45983
      Homo sapiens CCR8 chemokine receptor (CMKBR8) gene, complete cds
      gi|2231165|gb|U45983.1|HSU45983[2231165]
    • 14015: X63819
      H. sapiens mRNA for Lipoxin A4 receptor
      gi|31460|emb|X63819.1|HSLIPA4R[31460]
    • 14016: X15274
      H. sapiens TRGV9 gene, allele V9*A2
      gi|1848091|emb|X15274.1|HSTRGV9F[1848091]
    • 14020: X80282
      H. sapiens gene for oxytocin receptor
      gi|609014|emb|X80282.1|HSOXYTOC[609014]
    • 14021: X81086
      H. sapiens PCaR1 gene
      gi|599819|emb|X81086.1|HSPCAR1[599819]
    • 14023: X65857
      H. sapiens HGMP07E gene for olfactory receptor
      gi|425220|emb|X65857.1|HSHGM07EG[425220]
    • 14024: X65858
      H. sapiens gene for high affinity IL-8 receptor
      gi|312046|emb|X65858.1|HSHAIL8G[312046]
    • 14026: Z69640
      H. sapiens fgfr2 gene (exon 5)
      gi|200062|emb|Z69640.1|HSFGFR2UB[1200062]
    • 14027: Z69641
      H. sapiens fgfr2 gene
      gi|1120006|emb|Z69641.1|HSFGFR2UA[1200061]
    • 14029: Z70243
      H. sapiens enhancer region for interleukin-2 receptor alpha chain
      gi|1769435|emb|Z70243.1|HSENHREG1[1769435]
    • 14030: Z38109
      H. sapiens DNA for CD69, exon 1
      gi|793837|emb|Z38109.1|HSCD69X1[793837]
    • 14031: AC002306
      Homo sapiens DNA from chromosome 19-cosmid R33799, genomic sequence, complete sequence
      gi|2213634|gb|AC002306.1|AC002306[2213634]
    • 14032: AF002256
      Homo sapiens killer cell inhibitory receptor homolog cl-9 mRNA, complete cds
      gi|2197058|gb|AF002256.1|AF002256[2197058]
    • 14033: AF002255
      Homo sapiens killer cell inhibitory receptor cl-17 mRNA, complete cds
      gi|2197056|gb|AF002255.1|AF002255[2197056]
    • 14034: D89079
      Homo sapiens mRNA for leukotriene b4 receptor, complete cds
      gi|2196450|dbj|D589079.1|D89079[2196450]
    • 14035: D89078
      Homo sapiens mRNA for leukotriene b4 receptor, complete cds
      gi|2196448|dbj|D89078.1|D89078[2196448]
    • 14036: AB004662
      Homo sapiens mRNA for adenosine A1-receptor, complete cds
      gi|2196442|dbj|AB004662.1|AB004662[2196442]
    • 14037: Y07909
      H. sapiens mRNA for Progression Associated Protein
      gi|1542882|emb|Y07909.1|HSPAPR[1542882]
    • 14038: L17411
      Human complement receptor type 1 (alleles S and F) gene, exon 40
      gi|1199855|gb|L17411.1|HUMCR1SF34[1199855]
    • 14039: L17425
      Human complement receptor type 1 (allele S) gene, exon 11
      gi|451301|gb|L17425.1|HUMCR1SF10[451301]
    • 14040: L17418
      Human complement receptor type 1 (alleles S and F) gene, exon 47 and complete cds's
      gi|306678|gb|L17418.1|HUMCR1SF41[306678]
    • 14041: L17417
      Human complement receptor type 1 (alleles S and F) gene, exon 46
      gi|306677|gb|L17417.1|HUMCR1SF40[306677]
    • 14042: L17416
      Human complement receptor type 1 (alleles S and F) gene, exon 45
      gi|306676|gb|L17416.1|HUMCR1SF39[306676]
    • 14043: L17415
      Human complement receptor type 1 (alleles S and F) gene, exon 44
      gi|306675|gb|L17415.1|HUMCR1SF38[306675]
    • 14044: L17414
      Human complement receptor type 1 (alleles S and F) gene, exon 43
      gi|306674|gb|L17414.1|HUMCR1SF37[306674]
    • 14045: L17413
      Human complement receptor type 1 (alleles S and F) gene, exon 42
      gi|306673|gb|L17413.1|HUMCR1SF36[306673]
    • 14046: L17412
      Human complement receptor type 1 (alleles S and F) gene, exon 41
      gi|306672|gb|L17412.1|HUMCR1SF35[306672]
    • 14047: L17410
      Human complement receptor type 1 (alleles S and F) gene, exons 38 and 39
      gi|306670|gb|L17410.1|HUMCR1SF33[306670]
    • 14048: L17408
      Human complement receptor type 1 (alleles S and F) gene, exon 37
      gi|306669|gb|L17408.1|HUMCR1SF32[306669]
    • 14049: L17407
      Human complement receptor type 1 (alleles S and F) gene, exon 36
      gi|306668|gb|L17407.1|HUMCR1SF31[306668]
    • 14050: L17406
      Human complement receptor type 1 (alleles S and F) gene, exon 35
      gi|306667|gb|L17406.1|HUMCR1SF30[306667]
    • 14051: L17405
      Human complement receptor type 1 (alleles S and F) gene, exon 34
      gi|306666|gb|L17405.1|HUMCR1SF29[306666]
    • 14052: L17404
      Human complement receptor type 1 (alleles S and F) gene, exon 33
      gi|306665|gb|L17404.1|HUMCR1SF28[306665]
    • 14053: L17403
      Human complement receptor type 1 (alleles S and F) gene, exon 32
      gi|306664|gb|L17403.1|HUMCR1SF27[306664]
    • 14054: L17402
      Human complement receptor type 1 (alleles S and F) gene, exons 30 and 31
      gi|306663|gb|L17402.1|HUMCR1SF26[306663]
    • 14055: L17401
      Human complement receptor type 1 (alleles S and F) gene, exon 29
      gi|306662|gb|L17401.1|HUMCR1SF25[306662]
    • 14056: L17400
      Human complement receptor type 1 (alleles S and F) gene, exon 28
      gi|306661|gb|L17400.1|HUMCR1SF24[306661]
    • 14057: L17398
      Human complement receptor type 1 (alleles S and F) gene, exons 26 and 27
      gi|306660|gb|L17398.1|HUMCR1SF23[306660]
    • 14058: L17397
      Human complement receptor type 1 (alleles S and F) gene, exon 25
      gi|306659|gb|L17397.1|HUMCR1SF22[306659]
    • 14059: L17396
      Human complement receptor type 1 (alleles S and F) gene, exon 24
      gi|306658|gb|L17396.1|HUMCR1SF21[306658]
    • 14060: L17395
      Human complement receptor type 1 (alleles S and F) gene, exons 22 and 23
      gi|306657|gb|L17395.1|HUMCR1SF20[306657]
    • 14061: L17394
      Human complement receptor type 1 (alleles S and F) gene, exon 21
      gi|306656|gb|L17394.1|HUMCR1SF19[306656]
    • 14062: L17393
      Human complement receptor type 1 (alleles S and F) gene, exon 20
      gi|306655|gb|L17393.1|HUMCR1SF18[306655]
    • 14063: L17392
      Human complement receptor type 1 (alleles S and F) gene, exon 19
      gi|306654|gb|L17392.1|HUMCR1SF17[306654]
    • 14064: L17391
      Human complement receptor type 1 (alleles S and F) gene, exon 18
      gi|306653|gb|L17391.1|HUMCR1SF16[306653]
    • 14065: L17430
      Human complement receptor type 1 (allele S) gene, exon 17
      gi|306652|gb|L17430.1|HUMCR1SF15[306652]
    • 14066: L17429
      Human complement receptor type 1 (allele S) gene, exon 16
      gi|306651|gb|L17429.1|HUMCR1SF14[306651]
    • 14067: L17428
      Human complement receptor type 1 (allele S) gene, exons 14 and 15
      gi|306650|gb|L17428.1|HUMCR1SF13[306650]
    • 14068: L17427
      Human complement receptor type 1 (allele S) gene, exon 13
      gi|306649|gb|L17427.1|HUMCR1SF12[306649]
    • 14069: L17426
      Human complement receptor type 1 (allele S) gene, exon 12
      gi|306648|gb|L17426.1|HUMCR1SF11[306648]
    • 14070: L17424
      Human complement receptor type 1 (allele S) gene, exon 10
      gi|306646|gb|L17424.1|HUMCR1SF09[306646]
    • 14071: L17423
      Human complement receptor type 1 (alleles S and F) gene, exon 9
      gi|306645|gb|L17423.1|HUMCR1SF08[306645]
    • 14072: L17422
      Human complement receptor type 1 (alleles S and F) gene, exon 8
      gi|306644|gb|L17422.1|HUMCR1SF07[306644]
    • 14073: L17421
      Human complement receptor type 1 (alleles S and F) gene, exons 6 and 7
      gi|306643|gb|L17421.1|HUMCR1SF06[306643]
    • 14074: L17420
      Human complement receptor type 1 (alleles S and F) gene, exon 5
      gi|306642|gb|L17420.1|HUMCR1SF05[306642]
    • 14075: L17419
      Human complement receptor type 1 (alleles S and F) gene, exon 4
      gi|306641|gb|L17419.1|HUMCR1SF04[306641]
    • 14076: L17409
      Human complement receptor type 1 (alleles S and F) gene, exon 3
      gi|306640|gb|L17409.1|HUMCR1SF03[306640]
    • 14077: L17399
      Human complement receptor type 1 (alleles S and F) gene, exon 2
      gi|306639|gb|L17399.1|HUMCR1SF02[306639]
    • 14078: L17390
      Human complement receptor type 1 (alleles S and F) gene, enhancer and exon 1
      gi|306638|gb|L17390.1|HUMCR1SF01[306638]
    • 14081: M14764
      Human nerve growth factor receptor mRNA, complete cds
      gi|189204|gb|M14764.1|HUMNGFR[189204]
    • 14082: M11025
      Human asialoglycoprotein receptor H2 mRNA, complete cds
      gi|179080|gb|M11025.1|HUMASGPR2[179080]
    • 14083: L31772
      Human alpha-1a/d adrenergic receptor mRNA, complete cds
      gi|666894|gb|L31772.1|HUMA1DA[666894]
    • 14084: L31774
      Human alpha-1c-adrenergic receptor mRNA, complete cds
      gi|666892|gb|L31774.1|HUMA1ARA[666892]
    • 14085: L31773
      Human alpha-1B-adrenergic receptor mRNA, complete cds
      gi|666890|gb|L31773.1|HUMA1AR[666890]
    • 14093: L07868
      Homo sapiens receptor tyrosine kinase (ERBB4) gene, complete cds
      gi|337359|gb|L07868.1|HUMRETYKIN[337359]
    • 14094: L19593
      Homo sapiens interleukin 8 receptor beta (IL8RB) mRNA, complete cds
      gi|559053|gb|L19593.1|HUMIL8RB[559053]
    • 14095: L19591
      Homo sapiens interleukin 8 receptor alpha (IL8RA) mRNA, complete cds
      gi|559049|gb|L19591.1|HUMIL8RAA[559049]
    • 14096: M69229
      Human insulin-like growth factor I receptor gene, promoter region and 5′ end
      gi|184837|gb|M69229.1|HUMIGFR1PR[184837]
    • 14097: L03840
      Human fibroblast growth factor receptor 4 (FGFR4) mRNA, complete cds
      gi|182570|gb|L03840.1|HUMFGFR4X[182570]
    • 14098: L13268
      Homo sapiens N-methyl-d-aspartate receptor (NR1-3) mRNA, 3′ end
      gi|292286|gb|L13268.1|HUMMARB[292286]
    • 14099: L13266
      Homo sapiens N-methyl-d-aspartate receptor (NR1-1) mRNA, complete cds
      gi|292282|gb|L13266.1|HUMMAR[292282]
    • 14100: Y13426
      Homo sapiens TCRDV2 gene, partial
      gi|2181879|emb|Y13426.1|HSTCRDV2[2181879]
    • 14101: Y08768
      H. sapiens mRNA for IL-13 receptor
      gi|1877211|emb|Y08768.1|HSIL13[1877211]
    • 14102: Y08110
      H. sapiens mRNA for mosaic protein LR11
      gi|1552323|emb|Y08110.1|HSLR11[1552323]
    • 14103: E08844
      Histamine H1 receptor gene
      gi|2176948|dbj|E08844.1|E08844[2176948]
    • 14104: E08843
      cDNA encoding Histamine H1 receptor
      gi|2176947|dbj|E08843.1|E08843[2176947]
    • 14106: E07873
      cDNA encoding cholecystokinin B/gastrin receptor
      gi|2176006|dbj|E07873.1|E07873[2176006]
    • 14107: E07650
      cDNA encoding endothelin receptor, ETB-receptor
      gi|2175785|dbj|E07650.1|E07650[2175785]
    • 14108: E07649
      cDNA encoding endothelin receptor, ETA-receptor
      gi|2175784|dbj|E07649.1|E07649[2175784]
    • 14109: E07358
      cDNA encoding adrenaline alpha2CII receptor
      gi|2175498|dbj|E07358.1|E07358[2175498]
    • 14110: E07278
      cDNA encoding human cholecystokinin (CCK) receptor
      gi|2175419|dbj|E07278.1|E07278[2175419]
    • 14111: E06799
      DNA encoding human Interleukin-5 receptor
      gi|2174981|dbj|E06799.1|E06799[2174981]
    • 14112: E06798
      DNA encoding human Interleukin-5 receptor
      gi|2174980|dbj|E06798.1|E06798[2174980]
    • 14113: E06797
      DNA encoding human Interleukin-5 receptor
      gi|2174979|dbj|E06797.1|E06797[2174979]
    • 14114: E06796
      DNA encoding human Interleukin-5 receptor
      gi|2174978|dbj|E06796.1|E06796[2174978]
    • 14115: E05678
      cDNA encoding human LH-hCG (luteinizing hormone-human choriogonadotropic hormone) receptor
      gi|2173865|dbj|E05678.1|E05678[2173865]
    • 14116: E05211
      DNA encoding human scavenger receptor II
      gi|2173401|dbj|E05211.1|E05211[2173401]
    • 14117: E05210
      DNA encoding human scavenger receptor I
      gi|2173400|dbj|E05210.1|E05210[2173400]
    • 14118: E05109
      cDNA encoding human oxytocin receptor
      gi|2173303|dbj|E05109.1|E05109[2173303]
    • 14189: E04823
      cDNA encoding interleukin 6 receptor
      gi|2173019|dbj|E04823.1|E04823[2173019]
    • 14190: E03879
      cDNA encoding platelet activating factor receptor
      gi|2172093|dbj|E03879.1|E03879[2172093]
    • 14191: E03829
      cDNA encoding human thromboxane receptor
      gi|2172043|dbj|E03829.1|E03829[2172043]
    • 14192: E03378
      DNA encoding N-terminal fragment of human growth hormone receptor
      gi|2171595|dbj|E03378.1|E03378[2171595]
    • 14193: E03377
      DNA encoding C-terminal fragment of human growth hormone receptor
      gi|2171594|dbj|E03377.1|E03377[2171594]
    • 14194: E03335
      Human b-FGF receptor gene
      gi|2171552|dbj|E03335.1|E03335[2171552]
    • 14195: E03268
      cDNA sequence coding for human scavenger receptor, type II
      gi|2171485|dbj|E03268.1|E03268[2171485]
    • 14196: E03267
      cDNA sequence coding for human scavenger receptor, type I
      gi|2171484|dbj|E03267.1|E03267[2171484]
    • 14197: E02673
      cDNA encoding human B cell stimulating factor 2 receptor protein
      gi|2170901|dbj|E02673.1|E02673[2170901]
    • 14198: E02541
      cDNA encoding human Interleukin-2 receptor L chain
      gi|2170771|dbj|E02541.1|E02541[2170771]
    • 14199: E02151
      Terminal sequence of constant region of T cell receptor beta chain (c beta-1)
      gi|2170389|dbj|E02151.1|E02151[2170389]
    • 14200: E01646
      cDNA encoding Fc epsilon receptor
      gi|2169899|dbj|E01646.1|E01646[2169899]
    • 14201: E01052
      DNA encoding human mature TNF
      gi|2169311|dbj|E01052.1|E01052[2169311]
    • 14202: E00999
      cDNA encoding human insulin receptor
      gi|2169258|dbj|E00999.1|E00999[2169258]
    • 14203: E00990
      cDNA encoding alpha chain of T-cell receptor
      gi|2169251|dbj|E00990.1|E00990[2169251]
    • 14204: E00727
      cDNA encoding human IL-2 receptor
      gi|2169004|dbj|E00727.1|E00727[2169004]
    • 14205: E00723
      cDNA encoding human interleukin-2 receptor
      gi|2169000|dbj|E00723.1|E00723[2169000]
    • 14206: E00685
      cDNA encoding human T-cell antigen receptor protein
      gi|2168964|dbj|E00685.1|E00685[2168964]
    • 14207: D31833
      Human mRNA for vasopressin V1b receptor, complete cds
      gi|563981|dbj|D31833.1|HUMVV1BR[563981]
    • 14208: D16845
      Human mRNA for thyrotropin-releasing hormone receptor, complete cds
      gi|577631|dbj|D16845.1|HUMTRHR1[577631]
    • 14209: D28131
      Human mRNA for TGF-beta receptor type IIB, partial sequence
      gi|456708|dbj|D28131.1|HUMTGFBRII[456708]
    • 14211: D17517
      Human sky mRNA for Sky, complete cds
      gi|624880|dbj|D17517.1|HUMSKY[624880]
    • 14214: D30780
      Human mRNA for phospholipase A2 receptor, partial cds
      gi|565645|dbj|D30780.1|HUMPLA21R[565645]
    • 14215: D38299
      Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 2 isoform, complete
      cds
      gi|1389574|dbj|D38299.1|HUMPEREFC[1389574]
    • 14216: D38298
      Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 1b isoform, complete
      cds
      gi|1389573|dbj|D38298.1|HUMPEREEB[1389573]
    • 14217: D38301
      Homo sapiens mRNA for prostaglandin E receptor EP3 subtype 3 isoform, complete
      cds
      gi|1389572|dbj|D38301.1|HUMPERECE[1389572]
    • 14218: D38300
      Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 4 isoform, complete
      cds
      gi|1389571|dbj|D38300.1|HUMPEREBD[1389571]
    • 14219: D38297
      Homo sapiens mRNA for prostaglandin E receotor EP3 subtype 1a isoform, complete
      cds
      gi|1389570|dbj|D38297.1|HUMPEREA[1389570]
    • 14220: D28538
      Human mRNA for metabotropic glutamate receptor subtype 5a, complete cds
      gi|1140805|dbj|D28538.1|HUMMGRS5A[1408051]
    • 14221: D14872
      Human DNA for fibroblast growth factor receptor 2 (K-sam-II) exon C3, partial sequence
      gi|511927|dbj|D14872.1|HUMKSAMC3[511927]
    • 14222: D50582
      Human gene for inward rectifier K channel, complete cds
      gi|1088444|dbj|D50582.1|HUMIRKCB[1088444]
    • 14223: D26070
      Human mRNA for type 1 inositol 1,4,5-trisphosphate receptor, complete cds
      gi|559322|dbj|D26070.1|HUMINSP3R1[559322]
    • 14232: D26156
      Human mRNA for transcriptional activator hSNF2b, complete cds
      gi|505087|dbj|D26156.1|HUMHSNF2B[505087]
    • 14233: D26155
      Human mRNA for transcriptional activator hSNF2a, complete cds
      gi|505086|dbj|D26155.1|HUMHSNF2A[505086]
    • 14234: D26351
      Human mRNA for type 3 inositol 1,4,5-trisphosphate receptor, complete cds
      gi|450470|dbj|D26351.1|HUMHT3I[450470]
    • 14235: D26350
      Human mRNA for type 2 inositol 1,4,5-trisphosphate receptor, complete cds
      gi|450468|dbj|D26350.1|HUMHT2I[450468]
    • 14236: D25418
      Human mRNA for prostacyclin receptor, complete cds
      gi|467509|dbj|D25418.1|HUMHPR[467509]
    • 14237: D10924
      Human mRNA for HM89
      gi|219868|dbj|D10924.1|HUMHM89[219868]
    • 14238: D10923
      Human mRNA for HM74
      gi|219866|dbj|D10923.1|HUMHM74[219866]
    • 14239: D10922
      Human mRNA for FMLP-related receptor (HM63)
      gi|219864|dbj|D10922.1|HUMHM63[219864]
    • 14240: D10925
      Human mRNA for HM145
      gi|219862|dbj|D10925.1|HUMHM145[219862]
    • 14241: D28481
      Human mRNA for histamine H1 receptor, complete cds
      gi|457654|dbj|D28481.1|HUMHH1R[457654]
    • 14242: D10995
      Human gene for serotonin 1B receptor, complete cds
      gi|219678|dbj|D10995.1|HUMHGCR[219678]
    • 14243: D38449
      Human mRNA for G protein-coupled receptor, complete cds
      gi|556519|dbj|D30449.1|HUMGPCRAA[556519]
    • 14243: D38449
    • 14245: D37827
      Homo sapiens mRNA for large erk/cek5 tyrosine kinase, partial cds
      gi|1060894|dbj|D37827.1|HUMERK1P[1060894]
    • 14246: D13305
      Human mRNA for brain cholecystokinin receptor
      gi|436039|dbj|D13305.1|HUMBRACHRE[436039]
    • 14247: D32201
      Human mRNA for alpha 1C adrenergic receptor isoform 3, complete cds
      gi|927210|dbj|D32201.1|HUMAICAR3[927210]
    • 14248: D16354
      Human mRNA for Ah receptor, complete cds
      gi|464179|dbj|D16354.1|HUMAHRE[464179]
    • 14249: D25235
      Human mRNA for alpha1C adrenergic receptor, complete cds
      gi|433200|dbj|D25235.1|HUMACAR[433200]
    • 14250: D13538
      Human alpha2CII-adrenergic receptor gene, complete cds
      gi|219405|dbj|D13538.1|HUMA2CIIA[219405]
    • 14251: D32202
      Human mRNA for alpha 1C adrenergic receptor isoform 2, complete cds
      gi|927208|dbj|D32202.1|HUMA1CAR2[927208]
    • 14253: D86519
      Human mRNA for neuropeptide y/peptide YY Y6 receptor, complete cds
      gi|1731789|dbj|D86519.1|D86519[1731789]
    • 14254: D50683
      Homo sapiens mRNA for TGF-betaIIR alpha, complete cds
      gi|1827474|dbj|D50683.1|D50683[1827474]
    • 14255: D50682
      Homo sapiens mRNA for TGF-betaIIR beta, partial cds
      gi|1827472|dbj|D50682.1|D50682[1827472]
    • 14256: D28472
      Human mRNA for prostaglandin E receptor EP4 subtype, complete cds
      gi|1486234|dbj|D28472.1|D28472[1486234]
    • 14257: D29634
      Human lung mRNA for receptor for prostacyclin, complete cds
      gi|577629|dbj|D29634.1|D29634[577629]
    • 14258: D28539
      Human mRNA for metabotropic glutamate receptor subtype 5b, complete cds
      gi|1408053|dbj|D28539.1|HUMMGRS5B[1408053]
    • 14259: Y09479
      H. sapiens mRNA for G protein-coupled receptor Edg-2
      gi|1679601|emb|Y09479.1|HSEDG2[1679601]
    • 14260: U97197
      Homo sapiens asialoglycoprotein receptor (ASGPR) mRNA, complete cds
      gi|2121249|gb|U97197.1|HSU97197[2121249]
    • 14261: X81892
      H. sapiens mA for HE6 Tm7 receptor
      gi|2117160|emb|X81892.1|HSHE6[2117160]
    • 14262: Y07619
      H. sapiens mRNA for peroxisome proliferator-activated receptor alpha
      gi|1514594|emb|Y07619.1|HSPPARAGE[1514594]
    • 14263: D16815
      Homo sapiens mRNA for EAR-1r, complete cds
      gi|2116671|dbj|D16815.1|D16815[2116671]
    • 14264: X95876
      H. sapiens mRNA for G-protein coupled receptor
      gi|1552845|emb|X95876.1|HSGPCRIN8[1552845]
    • 14265: AF000545
      Homo sapiens putative purinergic receptor P2Y10 gene, complete cds
      gi|2104786|gb|AF000545.1|HSAF000545[2104786]
    • 14267: U95626
      Homo sapiens ccr2b (ccr2), ccr2a (ccr2), ccr5 (ccr5) and ccr6 (ccr6) genes, complete cds, and lactoferrin (lactoferrin) gene, partial cds, complete sequence
      gi|2104517|gb|U95626.1|HSU95626[2104517]
    • 14268: U77352
      Homo sapiens MAP kinase-activating death domain protein (MADD) mRNA, complete cds
      gi|2102697|gb|U77352.1|HSU77352[2102697]
    • 14269: D86098
      Homo sapiens mRNA for prostaglandin EP3 receptor subtype isoform, complete cds
      gi|2102646|dbj|D86098.1|D86098[2102646]
    • 14270: D86097
      Homo sapiens mRNA for prostaglandin EP3 receptor subtype isoform, complete cds
      gi|2102644|dbj|D86097.1|D86097[2102644]
    • 14271: X98510
      H. sapiens mRNA for G protein-coupled receptor
      gi|1894788|emb|X98510.1|HSX98510[1894788]
    • 14272: D89675
      Homo sapiens mRNA for bone morphogenetic protein type IB receptor, complete cds
      gi|2055308|dbj|D89675.1|D89675[2055308]
    • 14273: D43772
      Human squamous cell carcinoma of esophagus mRNA for GRB-7 SH2 domain protein, complete cds
      gi|601890|dbj|D43772.1|HUMGRB7[601890]
    • 14274: X89677
      H. sapiens RA for TPCR92 protein
      gi|902337|emb|X89677.1|HSTPCR92P[902337]
    • 14275: X89676
      H. sapiens mRNA for TPCR86 protein
      gi|902335|emb|X89676.1|HSTPCR86P[902335]
    • 14276: X89675
      H. sapiens mRNA for TPCR85 protein
      gi|902333|emb|X89675.1|HSTPCR85P[902333]
    • 14277: X89674
      H. sapiens mRNA for TPCR27 protein
      gi|902331|emb|X89674.1|HSTPCR27P[902331]
    • 14278: X89673
      H. sapiens mRNA for TPCR26 protein
      gi|902329|emb|X89673.1|HSTPCR26P[902329]
    • 14279: X89672
      H. sapiens mRNA for TPCR25 protein
      gi|902327|emb|X89672.1|HSTPCR25P[902327]
    • 14280: X89671
      H. sapiens mRNA for TPCR24 protein
      gi|902325|emb|X89671.1|HSTPCR24P[902325]
    • 14281: X89670
      H. sapiens mRNA for TPCR16 protein
      gi|902323|emb|X89670.1|HSTPCR16P[902323]
    • 14282: X89669
      H. sapiens mRNA for TPCR120 protein
      gi|902321|emb|X89669.1|HSTPCR120[902321]
    • 14283: X89668
      H. sapiens mRNA for TPCR110 protein
      gi|902319|emb|X89668.1|HSTPCR110[902319]
    • 14284: X89667
      H. sapiens mRNA for TPCR106 protein
      gi|902317|emb|X89667.1|HSTPCR106[902317]
    • 14285: X89666
      H. sapiens mRNA for TPCR100 protein
      gi|902315|emb|X89666.1|HSTPCR100[902315]
    • 14291: X73617
      H. sapiens mRNA for T-cell receptor delta
      gi|402624|emb|X73617.1|HSTCRDE[402624]
    • 14292: Z79612
      H. sapiens DNA for muscle nicotinic acetylcholine receptor gene promotor, clone
      DBLambda20
      gi|1922318|emb|Z79612.1|HSMNAR3[1922318]
    • 14293: Z79611
      H. sapiens DNA for muscle nicotinic acetylcholine receptor gene promotor, clone
      DBLambda23
      gi|1922317|emb|Z79611.1|HSMNAR2[1922317]
    • 14294: Z79610
      H. sapiens DNA for muscle nicotinic acetylcholine receptor gene promotor, clone
      ICRFc105F02104
      gi|1922316|emb|Z79610.1|HSMNAR1[1922316]
    • 14295: Y09852
      H. sapiens FGFR3 gene, partial
      gi|1922307|emb|Y09852.1|HSFGFR312[1922307]
    • 14309: Z46223
      H. sapiens DNA for immunoglobulin G Fc receptor IIIB
      gi|559446|emb|Z46223.1|HSIGGRE3B[559446]
    • 14310: Z46222
      H. sapiens DNA for immunoglobulin G Fc receptor 111A
      gi|559445|emb|Z46222.1|HSIGGRE3A[559445]
    • 14311: Y09561
      H. sapiens mRNA for P2X7 receptor
      gi|1854511|emb|Y09561.1|HSP2X7[1854511]
    • 14312: Y09328
      H. sapiens mRNA for IL13 receptor alpha-1 chain
      gi|1885307|emb|Y09328.1|HSIL13RA1[1885307]
    • 14313: Y07593
      H. sapiens mRNA for 46 kDa coxsackievirus and adenovirus receptor (CAR) protein
      gi|1881446|emb|Y07593.1|HS46 KDA[1881446]
    • 14314: X07205
      H. sapiens TRGV9 gene, allele V9*A1
      gi|1848089|emb|X07205.1|HSTRGV9[1848089]
    • 14315: X15272
      H. sapiens TRGV4F gene
      gi|1841921|emb|X15272.1|HSTRGV4F[1841921]
    • 14316: Y11227
      H. sapiens TRGV11 gene
      gi|1848086|emb|Y11227.1|HSTRGV11G[1848086]
    • 14317: X74798
      H. sapiens TRGV10 gene, allele V10*A2
      gi|1848083|emb|X74798.1|HSTRGV[1848083]
    • 14321: X80878
      H. sapiens R kappa B mRNA
      gi|695578|emb|X80878.1|HSTRGV[695578]
    • 14324: X70070
      H. sapiens mRNA for neurotensin receptor
      gi|35020|emb|X70070.1|HSNEURA[35020]
    • 14325: X94552
      H. sapiens mRNA for metabotropic glutamate receptor type 7
      gi|1370110|emb|X94552.1|HSMGLU7[1370110]
    • 14326: X89105
      H. sapiens krag-like mRNA
      gi|939922|emb|X89105.1|HSKRAGGEN[939922]
    • 14327: X92562
      H. sapiens mRNA for myeloid IgA Fc receptor, CD89 (539 bp)
      gi|1296655|emb|X92562.1|HSIGAFCR5[1296655]
    • 14328: X92561
      H. sapiens mRNA for myeloid IgA Fc receptor, CD89 (585 bp)
      gi|1296654|emb|X92561.1|HSIGAFCR4[1296654]
    • 14329: X92560
      H. sapiens mRNA for myeloid IgA Fc receptor, CD89 (807 bp)
      gi|1296653|emb|X92560.1|HSIGAFCR3[1296653]
    • 14330: X92559
      H. sapiens mRNA for myeloid IgA Fc receptor, CD89 (771 bp)
      gi|1296652|emb|X92559.1|HSIGAFCR2[1296652]
    • 14331: X92558
      H. sapiens mRNA for myeloid IgA Fc receptor, CD89 (837 bp)
      gi|1296651|emb|X92558.1|HSIGAFCR1[1296651]
    • 14332: Z50197
      H. sapiens FGFR2, Bek gene (partial; mutation C)
      gi|929635|emb|Z50197.1|HSFGFR2XC[929635]
    • 14333: Z50196
      H. sapiens FGFR2, Bek gene (partial; mutation B)
      gi|929634|emb|Z50196.1|HSFGFR2XB[929634]
    • 14334: Z50201
      H. sapiens FGFR2 gene (partial; mutation A)
      gi|929633|emb|Z50201.1|HSFGFR2XA[929633]
    • 14335: X72304
      H. sapiens mRNA for corticotrophin releasing factor receptor
      gi|436118|emb|X72304.1|HSCRFA[436118]
    • 14336: X86169
      H. sapiens B2-bradykinin receptor gene, exon 2, C allele
      gi|1220165|emb|X86169.1|HSB2BRX2C[1220165]
    • 14342: X03131
      H. sapiens interleukin 2 receptor gene 5′ flanking region and exon 1 (and joined
      CDS)
      gi|33818|emb|X03131.1|HSIL2RG1[33818]
    • 14343: X57740
      H. sapiens rearranged T-cell receptor gamma chain gene, V3RS-J1 (hybrid joint)
      gi|505478|emb|X57740.1|HSTCRHJD[505478]
    • 14344: X01719
      H. sapiens gene fragment for the acetylcholine receptor gamma subunit (exon 7 and
      8)
      gi|28278|emb|X01719.1|HSACHG5[28278]
    • 14345: X01715
      H. sapiens gene fragment for the acetylcholine receptor gamma subunit precursor
      (exons 1 and 2)
      gi|28268|emb|X01715.1|HSACHG1[28268]
    • 14535: Z30429
      H. sapiens gene for early lymphocyte activation antigen CD69, exon 4
      gi|534947|emb|Z30429.1|HSLACD694[534947]
    • 14536: X89744
      H. sapiens mRNA for neuronal acetylcholine receptor alpha-4 subunit, exon 4
      gi|1279462|emb|X89744.1|HSCHRNA44[1279462]
    • 14537: X87765
      H. sapiens CD89 gene, exon TM/C
      gi|963045|emb|X87765.1|HSCD89EX5[963045]
    • 14538: X87766
      H. sapiens CD89 gene, exon EC2
      gi|963044|emb|X87766.1|HSCD89EX4[963044]
    • 14539: X87769
      H. sapiens CD89 gene, exon EC1
      gi|963043|emb|X87769.1|HSCD89EX3[963043]
    • 14540: X87768
      H. sapiens CD89 gene, exon S2
      gi|963042|emb|X87768.1|HSCD89EX2[963042]
    • 14541: X87767
      H. sapiens CD89 gene, exon S1
      gi|963041|emb|X87767.1|HSCD89EX1[963041]
    • 14542: AH004970
      Homo sapiens (clone Q-20D3) interferon receptor (IFNAR2) gene
      gi|995299|gb|AH004970.1|SEG_HUMIFNAMO[995299]
    • 14543: L42243
      Homo sapiens (clone 51H8) alternatively spliced interferon receptor (IFNAR2) gene, exon 9 and complete cds's
      gi|995298|gb|L42243.1|HUMIFNAM08[995298]
    • 14544: L41944
      Homo sapiens interferon receptor ifnar2-1 (splice variant IFNAR2-1) mRNA, complete cds
      gi|995296|gb|L41944.1|HUMIFNAL[995296]
    • 14545: L41943
      Homo sapiens interferon receptor ifnar2-3 (splice variant IFNAR2-3) mRNA, complete cds
      gi|995294|gb|L41943.1|HUMIFNAK[995294]
    • 14546: L41942
      Homo sapiens interferon receptor ifnar2-2 (splice variant IFNAR2-2) mRNA, complete cds
      gi|995292|gb|L41942.1|HUMIFNAJ[995292]
    • 14547: L42242
      Homo sapiens (clone Q-20D3) interferon receptor (IFNAR2) gene, exon 8
      gi|994722|gb|L42242.1|HUMIFNAM07[994722]
    • 14548: L42241
      Homo sapiens (clone Q-20D3) interferon receptor (IFNAR2) gene, exon 7
      gi|994721|gb|L42241.1|HUMIFNAM06[994721]
    • 14549: L42323
      Homo sapiens (clone 20D3) interferon receptor (IFNAR2) gene, exon 6
      gi|994720|gb|L42323.1|HUMIFNAM05[994720]
    • 14550: L42240
      Homo sapiens (clone Q-20D3) interferon receptor (IFNAR2) gene, exon 5
      gi|994719|gb|L42240.1|HUMIFNAM04[994719]
    • 14551: L42239
      Homo sapiens (clone Q-20D3) interferon receptor (IFNAR2) gene, exons 3-4
      gi|994718|gb|L42239.1|HUMIFNAM03[994718]
    • 14552: L42238
      Homo sapiens (clone Q-20D3) interferon receptor (IFNAR2) gene, exon 2
      gi|994717|gb|L42238.1|HUMIFNAM02[994717]
    • 14553: L42237
      Homo sapiens (clone Q-20D3) interferon receptor (IFNAR2) gene, exon 1
      gi|994716|gb|L42237.1|HUMIFNAM01[994716]
    • 14557: X94647
      H. sapiens CD97 gene exon 20
      gi|1165083|emb|X94647.1|HSX94647[1165083]
    • 14558: X94630
      H. sapiens CD97 gene exon 1 (and joined CDS)
      gi|1165073|emb|X94630.1|HSX94630[1165073]
    • 14560: X91747
      H. sapiens gene for FSH receptor (exon 10)
      gi|1009412|emb|X91747.1|HSFSHRX10[1009412]
    • 14561: X74979
      H. sapiens TRK E mRNA
      gi|400462|emb|X74979.1|HSTRKE[400462]
    • 14562: Y10100
      H. sapiens ACTH receptor promoter & exon 1
      gi|1743254|emb|Y10100.11HSACTHPRO[1743254]
    • 14563: Y09028
      H. sapiens NTRK1 gene, exon 1 (and joined mRNA)
      gi|1785644|emb|Y09028.1|HSNTRK11[1785644]
    • 14564: Y07684
      H. sapiens mRNA for P2X4 purinoceptor
      gi|1781008|emb|Y07684.1|HSP2X4PC[1781008]
    • 14565: X95712
      H. sapiens mRNA for receptor protein tyrosine phosphatase
      gi|1666422|emb|X95712.1|HSRPTYRPH[1666422]
    • 14568: X97232
      H. sapiens mRNA for NK receptor, clone library D97.10
      gi|1770483|emb|X97232.1|HSNKRD9[1770483]
    • 14569: X97233
      H. sapiens mRNA for NK receptor, clone library C97.12#5
      gi|1770481|emb|X97233.1|HSNKRC9[1770481]
    • 14570: X97231
      H. sapiens mRNA for NK receptor, clone library 59C/K3
      gi|1770479|emb|X97231.1|HSNKR59[1770479]
    • 14571: X97230
      H. sapiens mRNA for NK receptor, clone library 4M1#6
      gi|1770477|emb|X97230.1|HSNKR4M[1770477]
    • 14572: X97229
      H. sapiens mRNA for NK receptor, clone library 15.212
      gi|1770475|emb|X97229.1|HSNKR15[1770475]
    • 14573: X99481
      H. sapiens mRNA for NK receptor, clone GR #19
      gi|1770473|emb|X99481.1|HSNKGR19[1770473]
    • 14574: X99480
      H. sapiens mRNA for NK receptor, clone NK3.3 #27
      gi|1770471|emb|X99480.1|HSNK3327[1770471]
    • 14575: X99479
      H. sapiens mRNA for NK receptor, clone 12.11C
      gi|1770469|emb|X99479.1|HSNK1211C[1770469]
    • 14576: X98118
      H. sapiens GRK4A gene
      gi|1770421|emb|X98118.1|HSGRK4AGE[1770421]
    • 14589: X83864
      H. sapiens EDG-3 gene
      gi|1770395|emb|X83864.1|HSEDG3[1770395]
    • 14590: Z48923
      H. sapiens mRNA for BMPR-II
      gi|1009409|emb|Z48923.1|HSBMPRII[1009409]
    • 14592: X84939
      H. sapiens mRNA for fibroblast growth factor receptor-3
      gi|695548|emb|X84939.1|HSFGFR3EX[695548]
    • 14593: X89604
      H. sapiens mRNA for metallothionein-III
      gi|914850|emb|X89604.1|HSMTIII[914850]
    • 14594: Z70276
      H. sapiens mRNA for fibroblast growth factor 12 (partial)
      gi|1749790|emb|Z70276.1|HSFGF12CR[1749790]
    • 14595: Z70275
      H. sapiens mRNA for fibroblast growth factor 11 (partial)
      gi|1749788|emb|Z70275.1|HSFGF11CR[1749788]
    • 14596: Y09392
      H. sapiens mRNA for WSL-LR, WSL-S1 and WSL-S2 proteins
      gi|1669690|emb|Y09392.1|HSWSL1[1669690]
    • 14597: X99031
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 14
      gi|1480251|emb|X99031.1|HSDRTK14[1480251]
    • 14598: X99029
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 11
      gi|1480247|emb|X99029.1|HSDRTK11[1480247]
    • 14599: Y08162
      H. sapiens mRNA for heptahelix receptor
      gi|1707499|emb|Y08162.1|HSHHR[1707499]
    • 14600: X98194
      H. sapiens gene encoding serotonin receptor, 5-HT7, exon 3
      gi|1707470|emb|X98194.1|HS5HT73[1707470]
    • 14601: X99025
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exons 6 & 7
      gi|1480257|emb|X99025.1|HSDRTK6[1480257]
    • 14615: X98147
      H. sapiens gene encoding serotonin receptor, 5-HT7, exon 2
      gi|1707469|emb|X98147.1|HS5HT72[1707469]
    • 14616: X98193
      H. sapiens gene encoding serotonin receptor, 5-HT7, exon 1 (and joined CDS)
      gi|1707467|emb|X98193.1|HS5HT71[1707467]
    • 14617: X90753
      H. sapiens mRNA for alternatively spliced IgA Fc receptor (CD89)
      gi|951268|emb|X90753.1|HSIGAFCGN[951268]
    • 14618: X70812
      H. sapiens gene for beta 3 adrenergic receptor
      gi|312398|emb|X70812.1|HSBARED[312398]
    • 14619: Z22971
      H. sapiens mRNA for M130 antigen extracellular variant
      gi|312147|emb|Z22971.1|HSM130AE[312147]
    • 14620: Z22970
      H. sapiens mRNA for M130 antigen cytoplasmic variant 2
      gi|312145|emb|Z22970.1|HSM130AC2[312145]
    • 14621: Z22969
      H. sapiens mRNA for M130 antigen cytoplasmic variant 1
      gi|312143|emb|Z22969.1|HSM130AC1[312143]
    • 14622: Z22968
      H. sapiens mRNA for M130 antigen
      gi|312141|emb|Z22968.1|HSM130A[312141]
    • 14623: X69680
      H. sapiens mRNA for bradykinin receptor
      gi|288798|emb|X69680.1|HSBKR[288798]
    • 14624: Z79784
      H. sapiens G protein-coupled receptor CKR-L3
      gi|1668737|emb|Z79784.1|HSCKRL3[1668737]
    • 14625: Z79782
      H. sapiens G protein-coupled receptor CKR-L1
      gi|1668735|emb|Z79782.1|HSCKRL1[1668735]
    • 14626: X94374
      H. sapiens mRNA for HLA class I inhibitory NK receptor (AMC5)
      gi|1495480|emb|X94374.1|HSNKRAMC5[1495480]
    • 14627: X94373
      H. sapiens mRNA for HLA class I inhibitory NK receptor (1.1)
      gi|1495478|emb|X94373.1|HSNKR11[1495478]
    • 14628: X93596
      H. sapiens mRNA for HLA specific NK receptor
      gi|1495476|emb|X93596.1|HSNKI8[1495476]
    • 14629: X93595
      H. sapiens mRNA for NK receptor (clone 17.1C)
      gi|1495474|emb|X93595.1|HSNKI7[1495474]
    • 14630: X94262
      H. sapiens mRNA for HLA-Bw4 specific inhibitory NK cell receptor
      gi|1495472|emb|X94262.1|HSNKCRMR[1495472]
    • 14631: X89772
      H. sapiens mRNA for interferon alpha/beta receptor (long form)
      gi|1620400|emb|X89772.1|HSRNAIABR[1620400]
    • 14632: X69516
      H. sapiens gene for folate receptor
      gi|288876|emb|X69516.1|HSFOLA[288876]
    • 14633: X97671
      H. sapiens mRNA for erythropoietin receptor
      gi|1310666|emb|X97671.1|HSERYTHR[1310666]
    • 14639: X97874
      H. sapiens EP4 prostaglandin receptor gene, exon III
      gi|1359732|emb|X97874.1|HSEP4EX3[1359732]
    • 14640: X97873
      H. sapiens EP4 prostaglandin receptor gene, exons I & II (and joined CDS)
      gi|1359730|emb|X97873.1|HSEP4EX12[1359730]
    • 14646: X99404
      H. sapiens mRNA for early response gene, Berg36
      gi|1480242|emb|X99404.1|HSBERG36[1480242]
    • 14647: Z49205
      H. sapiens mRNA for purinergic receptor
      gi|798835|emb|Z49205.1|HSATPRMR[798835]
    • 14650: X89066
      H. sapiens mRNA for TRPC1 protein
      gi|1370118|emb|X89066.1|HSTRPC1GN[1370118]
    • 14671: Y08218
      H. sapiens mRNA for ryanodine receptor 2
      gi|1561613|emb|Y08218.1|HSRYAN2[1561613]
    • 14678: X96586
      H. sapiens mRNA for FAN protein
      gi|1556398|emb|X96586.1|HSFAN[1556398]
    • 14679: Z48226
      H. sapiens partial gene for receptor-type protein tyrosine phosphatase IA-2
      gi|667014|emb|Z48226.1|HSPTPAIA2[667014]
    • 14680: X91665
      H. sapiens B2-bradykinin receptor gene (allele BE-R33)
      gi|121615|emb|X91665.1|HSB2BER33[1216151]
    • 14681: L05424
      Human cell surface glycoprotein CD44 (CD44) gene, 3′ end of long tailed isoform
      gi|337956|gb|L05424.1|HUMSCG19[337956]
    • 14682: L05423
      Human cell surface glycoprotein CD44 (CD44) gene, exon 18, 3′ end of short tailed isoform
      gi|337955|gb|L05423.1|HUMSCG18[337955]
    • 14683: L05422
      Human cell surface glycoprotein CD44 (CD44) gene, exon 17
      gi|337954|gb|L05422.1|HUMSCG17[337954]
    • 14684: L05421
      Human cell surface glycoprotein CD44 (CD44) gene, exon 16
      gi|337953|gb|L05421.1|HUMSCG16[337953]
    • 14685: L05420
      Human cell surface glycoprotein CD44 (CD44) gene, exon 15
      gi|337952|gb|L05420.1|HUMSCG1S[337952]
    • 14686: L05419
      Human cell surface glycoprotein CD44 (CD44) gene, exon 14
      gi|337951|gb|L05419.1|HUMSCG14[337951]
    • 14687: L05418
      Human cell surface glycoprotein CD44 (CD44) gene, exon 13
      gi|337950|gb|L05418.1|HUMSCG13[337950]
    • 14688: L05417
      Human cell surface glycoprotein CD44 (CD44) gene, exon 12
      gi|337949|gb|L05417.1|HUMSCG12[337949]
    • 14689: L05416
      Human cell surface glycoprotein CD44 (CD44) gene, exon 11
      gi|337948|gb|L05416.1|HUMSCG11[337948]
    • 14690: L05415
      Human cell surface glycoprotein CD44 (CD44) gene, exon 10
      gi|337947|gb|L05415.1|HUMSCG10[337947]
    • 14691: L05414
      Human cell surface glycoprotein CD44 (CD44) gene, exon 9
      gi|337946|gb|L05414.1|HUMSCG09[337946]
    • 14692: L05413
      Human cell surface glycoprotein CD44 (CD44) gene, exon 8
      gi|337945|gb|L05413.1|HUMSCG08[337945]
    • 14693: L05412
      Human cell surface glycoprotein CD44 (CD44) gene, exon 7
      gi|337944|gb|L05412.1|HUMSCG07[337944]
    • 14694: L05411
      Human cell surface glycoprotein CD44 (CD44) gene, exon 6
      gi|337943|gb|L05411.1|HUMSCG06[337943]
    • 14695: L05410
      Human cell surface glycoprotein CD44 (CD44) gene, exon 5
      gi|337942|gb|L05410.1|HUMSCG05[337942]
    • 14696: L05409
      Human cell surface glycoprotein CD44 (CD44) gene, exon 4
      gi|33794|gb|L05409.1|HUMSCG04[337941]
    • 14697: L05408
      Human cell surface glycoprotein CD44 (CD44) gene, exon 3
      gi|337940|gb|L05408.1|HUMSCG03[337940]
    • 14698: L05407
      Human cell surface glycoprotein CD44 (CD44) gene, exon 2
      gi|337939|gb|L05407.1|HUMSCG02[337939]
    • 14699: M69214
      Human hyaluronate receptor (CD44) gene, exon 1
      gi|180127|gb|M69215.1|HUMSCG01[180127]
    • 14700: X91492
      H. sapiens ChemR13 gene
      gi|1262810|emb|X91492.1|HSCCCKR4G[1262810]
    • 14701: X91742
      H. sapiens gene for FSH receptor (exon 5)
      gi|1051149|emb|X91742.1|HSFSHRX5[1051149]
    • 14702: X91746
      H. sapiens gene for FSH receptor (exon 9)
      gi|1009420|emb|X91746.1|HSFSHRX9[1009420]
    • 14703: X91745
      H. sapiens gene for FSH receptor (exon 8)
      gi|1009419|emb|X91745.1|HSFSHRX8[1009419]
    • 14704: X91744
      H. sapiens gene for FSH receptor (exon 7)
      gi|1009418|emb|X91744.1|HSFSHRX7[1009418]
    • 14705: X91743
      H. sapiens gene for FSH receptor (exon 6)
      gi|1009417|emb|X91743.1|HSFSHRX6[1009417]
    • 14706: X91741
      H. sapiens gene for FSH receptor (exon 4)
      gi|1009415|emb|X91741.1|HSFSHRX4[1009415]
    • 14707: X91740
      H. sapiens gene for FSH receptor (exon 3)
      gi|1009414|emb|X91740.1|HSFSHRX3[1009414]
    • 14708: X91739
      H. sapiens gene for FSH receptor (exon 2)
      gi|1009413|emb|X91739.1|HSFSHRX2[1009413]
    • 14709: X91738
      H. sapiens gene for FSH receptor (exon 1)
      gi|1009411|emb|X91738.1|HSFSHRX1[1009411]
    • 14710: A34990
      H. sapiens TSH receptor
      gi|1568335|emb|A34990.1|A34990[1568335]
    • 14729: A23337
      H. sapiens mRNA for 5-HT2 receptor
      gi|1566776|emb|A23337.1|A23337[1566776]
    • 14730: X95095
      H. sapiens mRNA for PDGFRalpha protein
      gi|1403334|emb|X95095.1|HSPDGFRAL[1403334]
    • 14731: X91875
      H. sapiens IGF2R gene exon & intron 1
      gi|1017421|emb|X91875.1|HSIGF2R1[1017421]
    • 14733: L40636
      Homo sapiens (clone FBK III 16) protein tyrosine kinase (NET PTK) mRNA, complete
      cds
      gi|1100111|gb|L40636.1|HUMEPHT2R[1100111]
    • 14734: X55077
      H. sapiens mRNA fragment for alpha-2 macroglobulin receptor
      gi|24762|emb|X55077.1|HSA2MR[24762]
    • 14735: X98330
      H. sapiens mRNA for ryanodine receptor 2
      gi|1526977|emb|X98330.1|HSRR2[1526977]
    • 14737: X80038
      H. sapiens PRR2 mRNA
      gi|1524087|emb|X80038.1|HSPRR2[1524087]
    • 14738: Z15017
      H. sapiens mRNA for glycoprotein 39 (gp39)
      gi|38483|emb|Z15017.1|HSGP39MR[38483]
    • 14740: Z36748
      H. sapiens mRNA for serotonin receptor
      gi|558382|emb|Z36748.1|HSSERRC[558382]
    • 14741: X97198
      H. sapiens mRNA for receptor phosphate PCP-2
      gi|1502342|emb|X97198.1|HSRECPCP2[1502342]
    • 14742: X81870
      H. sapiens DNA for macrophage stimulating protein receptor
      gi|1491705|emb|X81870.1|HSDNAMSPR[1491705]
    • 14743: Z11168
      H. sapiens 5HT1A receptor region
      gi|1033027|emb|Z11168.1|HS5HT1A[1033027]
    • 14744: M75105
      Human neurokinin-2 receptor (TAC2R) gene, exon 5
      gi|189219|gb|M75105.1|HUMNK25[189219]
    • 14745: M75104
      Human neurokinin-2 receptor (NK-2) gene, exon 4
      gi|189218|gb|M75104.1|HUMNK24[189218]
    • 14746: M75103
      Human neurokinin-2 receptor (NK-2) gene, exon 3
      gi|189217|gb|M75103.1|HUMNK23[189217]
    • 14747: M75102
      Human neurokinin-2 receptor (NK-2) gene, exon 2
      gi|189216|gb|M75102.1|HUMNK22[189216]
    • 14748: M75101
      Human neurokinin-2 receptor (TAC2R) gene, exon 1
      gi|189215|gb|M75101.1|HUMNK21[189215]
    • 14750: X76981
      H. sapiens mRNA for adenosin receptor A3
      gi|440547|emb|X76981.1|HSRADRA3[440547]
    • 14751: X95302
      H. sapiens mRNA for IL13 receptor
      gi|1483349|emb|X95302.1|HSIL13REC[1483349]
    • 14752: X51469
      H. sapiens cell receptor gamma-chain J1-C1 DNA fragment (Raji cell line)
      gi|1480294|emb|X51469.1|HSRAJI[1480294]
    • 14753: X99027
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 9
      gi|1480259|emb|X99027.1|HSDRTK9[1480259]
    • 14754: X99026
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 8
      gi|1480258|emb|X99026.1|HSDRTK8[1480258]
    • 14755: X99024
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 5
      gi|1480256|emb|X99024.1|HSDRTK5[1480256]
    • 14756: X99023
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 4
      gi|1480255|emb|X99023.1|HSDRTK4[1480255]
    • 14757: X99034
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 17
      gi|1480254|emb|X99034.1|HSDRTK17[1480254]
    • 14758: X99033
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 16
      gi|1480253|emb|X99033.1|HSDRTK16[1480253]
    • 14759: X99032
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 15
      gi|1480252|emb|X99032.1|HSDRTK15[1480252]
    • 14760: X98208
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exons 1, 2, 3 and joined CDS
      gi|1480249|emb|X98208.1|HSDRTK123[1480249]
    • 14761: X99030
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exons 12 & 13
      gi|1480248|emb|X99030.1|HSDRTK12[1480248]
    • 14762: X99028
      H. sapiens gene encoding discoidin receptor tyrosine kinase, exon 10
      gi|1480246|emb|X99028.1|HSDRTK10[1480246]
    • 14763: X51470
      H. sapiens T-cell receptor gamma-chain J1-C1 DNA fragment (D-PLL cell line)
      gi|1480245|emb|X51470.1|HSDPLL[1480245]
    • 14764: L76631
      Homo sapiens metabotropic glutamate receptor 1 beta (mGluR1beta) mRNA, complete
      cds
      gi|1477389|gb|L76631.1|HUMMGLUB[1477389]
    • 14765: L76627
      Homo sapiens metabotropic glutamate receptor 1 alpha (mGluR1alpha) mRNA, complete cds
      gi|1477387|gb|L76627.1|HUMMGLUB[1477387]
    • 14766: L57508
      Homo sapiens Cak receptor kinase mRNA, complete cds
      gi|1160924|gb|L57508.1|HUMCAKA[1160924]
    • 14767: L38019
      Homo sapiens (clone HUM-IP3R1) inositol 1,4,5-trisphosphate receptor type 1 mRNA, complete cds
      gi|1464750|gb|L38019.1|HUMITR[1464750]
    • 14768: X77748
      H. sapiens mRNA for metabotropic glutamate receptor type 3
      gi|1171563|emb|X77748.1|HSMGLUR3[1171563]
    • 14769: M26016
      Human CR2/CD21/C3d/Epstein-Barr virus receptor gene, exon IC
      gi|181935|gb|M26016.1|HUMEBUR13[181935]
    • 14770: X63717
      H. sapiens mRNA for APO-1 cell surface antigen
      gi|28741|emb|X63717.1|HSAPO1[28741]
    • 14771: L03718
      Human G protein-coupled receptor (kinase-like) gene, complete cds
      gi|183598|gb|L03718.1|HUMGPRKLG[183598]
    • 14773: X99269
      H. sapiens NPYY1 gene
      gi|1430810|emb|X99269.1|HSNPYY1[1430810]
    • 14774: X95536
      H. sapiens earl gene
      gi|418937|emb|X95536.1|HSREOR[1418937]
    • 14775: X63745
      H. sapiens ERD2.2 mRNA for KDEL receptor
      gi|31217|emb|X63745.1|HSERD22[31217]
    • 14777: X98133
      H. sapiens gene encoding histamine H2 receptor
      gi|1359758|emb|X98133.1|HSH2R[1359758]
    • 14778: X89893
      H. sapiens mRNA for NK receptor (183 ActI)
      gi|1103680|emb|X89893.1|HSNKRECT2[1103680]
    • 14779: X89892
      H. sapiens mRNA for NK receptor (Eb6 ActI)
      gi|1103678|emb|X89892.1|HSNKRECT1[1103678]
    • 14780: X98178
      H. sapiens mRNA for MACH-beta-4 protein
      gi|1403330|emb|X98178.1|HSMACHB4[1403330]
    • 14781: X98177
      H. sapiens mRNA for MACH-beta-3 protein
      gi|1403328|emb|X98177.1|HSMACHB3[1403328]
    • 14782: X98175
      H. sapiens mRNA for MACH-beta-2 protein
      gi|1403326|emb|X98175.1|HSMACHB2[1403326]
    • 14783: X98176
      H. sapiens mRNA for MACH-beta-1 protein
      gi|1403324|emb|X98176.1|HSMACHB1[1403324]
    • 14784: X98173
      H. sapiens mRNA for MACH-alpha-2 protein
      gi|1403320|emb|X98173.1|HSMACHA2[1403320]
    • 14785: X67594
      H. sapiens mRNA for MSH receptor
      gi|1405733|emb|X67594.1|HSMSHRECA[1405733]
    • 14786: X96597
      H. sapiens gene encoding G protein coupled receptor
      gi|1296631|emb|X96597.1|HSGPCRE[1296631]
    • 14789: M88714
      Human bradykinin receptor (BK-2) mRNA, complete cds
      gi|1387999|gb|M88714.1|HUMBK2A[1387999]
    • 14790: AH003589
      Homo sapiens sulfonylurea receptor (SUR1) gene
      gi|1374918|gb|AH003589.1|SEG_HUMSUR1G[1374918]
    • 14791: L78243
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 39
      gi|1374917|gb|L78243.1|HUMSUR1G38[1374917]
    • 14792: L78242
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 38
      gi|1374916|gb|L78242.1|HUMSUR1G37[1374916]
    • 14793: L78241
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 37
      gi|1374915|gb|L78241.1|HUMSUR1G36[1374915]
    • 14794: L78240
      Homo sapiens sulfonylurea receptor (SUR1) gene, exons 34, 35, and 36
      gi|1374914|gb|L78240.1|HUMSUR1G35[1374914]
    • 14795: L78239
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 33
      gi|1374913|gb|L78239.1|HUMSUR1G34[1374913]
    • 14796: L78238
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 32
      gi|1374912|gb|L78238.1|HUMSUR1G33[1374912]
    • 14797: L78237
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 31
      gi|1374911|gb|L78237.1|HUSUR1G32[1374911]
    • 14798: L78236
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 30
      gi|1374910|gb|L78236.1|HUMSUR1G31[1374910]
    • 14799: L78235
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 29
      gi|1374909|gb|L78235.1|HUMSUR1G30[1374909]
    • 14800: L78234
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 28
      gi|1374908|gb|L78234.1|HUMSUR1G29[1374908]
    • 14801: L78233
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 27
      gi|1374907|gb|L78233.1|HUMSUR1G28[1374907]
    • 14802: L78232
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 26
      gi|1374906|gb|L78232.1|HUMSUR1G27[1374906]
    • 14803: L78231
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 25
      gi|1374905|gb|L78231.1|HUMSUR1G28[1374905]
    • 14804: L78230
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 24
      gi|1374904|gb|L78230.1|HUMSUR1G25[1374904]
    • 14805: L78229
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 23
      gi|1374903|gb|L78229.1|HUMSUR1G24[1374903]
    • 14806: L78228
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 22
      gi|1374902|gb|L78228.1|HUMSUR1G23[1374902]
    • 14807: L78227
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 21
      gi|1374901|gb|L78227.1|HUMSUR1G22[1374901]
    • 14808: L78226
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 20
      gi|1374900|gb|L78226.1|HUMSUR1G21[1374900]
    • 14809: L78254
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 19
      gi|1374899|gb|L78254.1|HUMSUR1G20[1374899]
    • 14810: L78225
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 18
      gi|1374898|gb|L78225.1|HUMSUR1G19[1374898]
    • 14811: L78224
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 17 (alternative)
      gi|1374897|gb|L78224.1|HUMSUR1G18[1374897]
    • 14812: L78223
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 17
      gi|1374896|gb|L78223.1|HUMSUR1G17[1374896]
    • 14813: L78222
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 16
      gi|1374895|gb|L78222.1|HUMSUR1G16[1374895]
    • 14814: L78221
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 15
      gi|1374894|gb|L78221.1|HUMSUR1G15[1374894]
    • 14815: L78220
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 14
      gi|1374893|gb|L78220.1|HUMSUR1G14[1374893]
    • 14816: L78219
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 13
      gi|1374892|gb|L78219.1|HUMSUR1G13[1374892]
    • 14817: L78218
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 12
      gi|1374891|gb|L78218.1|HUMSUR1G12[1374891]
    • 14818: L78217
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 11
      gi|1374890|gb|L78217.1|HUMSUR1G11[1374890]
    • 14819: L78216
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 10
      gi|1374889|gb|L78216.1|HUMSUR1G10[1374889]
    • 14820: L78215
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 9
      gi|1374888|gb|L78215.1|HUMSUR1G09[1374888]
    • 14821: L78214
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 8
      gi|1374887|gb|L78214.1|HUMSUR1G08[1374887]
    • 14822: L78213
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 7
      gi|1374886|gb|L78213.1|HUMSUR1G07[1374886]
    • 14823: L78255
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 6
      gi|1374885|gb|L78255.1|HUMSUR1G06[1374885]
    • 14824: L78212
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 5
      gi|1374884|gb|L78212.1|HUMSUR1G05[1374884]
    • 14825: L78211
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 4
      gi|1374883|gb|L78211.1|HUMSUR1G04[1374883]
    • 14826: L78210
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 3
      gi|1374882|gb|L78210.1|HUMSUR1G03[1374882]
    • 14827: L78209
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 2
      gi|137488|gb|L78209.1|HUMSUR1G02[1374881]
    • 14828: L78208
      Homo sapiens sulfonylurea receptor (SUR1) gene, exon 1
      gi|1374880|gb|L78208.1|HUMSUR1G01[1374880]
    • 14829: L78207
      Homo sapiens sulfonylurea receptor (SUR1) mRNA, complete cds
      gi|1374674|gb|L78207.1|HUMSUR1RNA[1374674]
    • 14830: X80818
      H. sapiens mRNA for metabotropic glutamate receptor type 4
      gi|1160182|emb|X80818.1|HSMGLUR4[1160182]
    • 14831: X89068
      H. sapiens mRNA for TRPC3 protein
      gi|1019789|emb|X89068.1|HSTRPC3GN[1019789]
    • 14832: X85740
      H. sapiens mRNA for C-C chemokine receptor-4
      gi|1370103|emb|X85740.1|HSCCCR3[1370103]
    • 14833: X72924
      H. sapiens STS in the vicinity of the ADRA2C gene, sequence tagged site
      gi|458814|emb|X72924.1|HSADRASTS[458814]
    • 14834: A27282
      H. sapiens TGR-CL3C
      gi|1247129|emb|A27282.1|A27282[1247129]
    • 14835: A27278
      H. sapiens TGR-CL5
      gi|1247127|emb|A27278.1|A27278[1247127]
    • 14836: A27276
      H. sapiens TGR-CL1
      gi|1247125|emb|A27276.1|A27276[1247125]
    • 14837: A27270
      H. sapiens TGR-CL10C
      gi|1247123|emb|A27270.1|A27270[1247123]
    • 14838: A10542
      H. sapiens low affinity Fc-epsilon-receptor
      gi|489152|emb|A10542.1|A10542[489152]
    • 14839: X84700
      H. sapiens mRNA for leucocyte antigen CD97
      gi|840770|emb|X84700.1|HSCD97[840770]
    • 14841: X56794
      H. sapiens CD44R mRNA
      gi|29798|emb|X56794.1|HSCD441[29798]
    • 14842: Z22924
      H. sapiens of CD36 gene, partial CDS
      gi|397604|emb|Z22924.1|HSCD36AA[397604]
    • 14843: X81121
      H. sapiens mRNA for central cannabinoid receptor, short isoform
      gi|736238|emb|X81121.1|HSCB1A[736238]
    • 14844: X74328
      H. sapiens mRNA for CB2 (peripheral) cannabinoid receptor
      gi|407806|emb|X74328.1|HSCB2CANR[407806]
    • 14852: X81120
      H. sapiens mRNA for central cannabinoid receptor
      gi|736236|emb|X81120.1|HSCANN6[736236]
    • 14853: X82466
      H. sapiens mRNA for calcitonin receptor
      gi|565026|emb|X82466.1|HSCALRECR[565026]
    • 14854: X69920
      H. sapiens mRNA for calcitonin receptor
      gi|474931|emb|X69920.1|HSCALRE[474931]
    • 14855: Z22672
      H. sapiens cacnl1a3 gene encoding skeletal muscle dhp-receptor alpha 1 subunit
      gi|297467|emb|Z22672.1|HSCACN1A[297467]
    • 14856: Z35761
      H. sapiens TEL/ABL fusion protien
      gi|601903|emb|Z35761.1|HSBREAKP3[601903]
    • 14862: X62515
      H. sapiens mRNA for basement membrane heparan sulfate proteoglycan
      gi|29469|emb|X62515.1|HSBMHSP[29469]
    • 14887: X70811
      H. sapiens mRNA for beta 3 adrenergic receptor
      gi|312396|emb|X70811.1|HSBARE[312396]
    • 14888: X69117
      H. sapiens mRNA for beta-adrenergic kinase 2
      gi|312394|emb|X69117.1|HSBADRK2[312394]
    • 14889: X61157
      H. sapiens mRNA for beta-adrenergic receptor kinase
      gi|288307|emb|X61157.1|HSBARK[288307]
    • 14891: X77584
      H. sapiens mRNA for ATL-derived factor/thiredoxin
      gi|453963|emb|X77584.1|HSATLRED[453963]
    • 14894: X70297
      H. sapiens mRNA for neuronal nicotinic acetylcholine receptor alpha-7 subunit
      gi|496606|emb|X70297.1|HSARA7A[496606]
    • 14901: Z11162
      H. sapiens gene for angiotensin II
      gi|28709|emb|Z11162.1|HSANTENII[28709]
    • 14902: X91162
      H. sapiens anti-mullerian hormone type II receptor exon 9
      gi|1107682|emb|X91162.1|HSAMREXO9[1107682]
    • 14903: X91164
      H. sapiens anti-mullerian hormone type II receptor exon 11
      gi|1107681|emb|X91164.1|HSAMREX11[1107681]
    • 14904: X91163
      H. sapiens anti-mullerian hormone type II receptor exon 10
      gi|1107680|emb|X91163.1|HSAMREX10[1107680]
    • 14905: X91161
      H. sapiens anti-mullerian hormone type II receptor exon 8
      gi|1107679|emb|X91161.1|HSAMREX08[1107679]
    • 14906: X91160
      H. sapiens anti-mullerian hormone type II receptor exon 7
      gi|1107678|emb|X91160.1|HSAMREX07[1107678]
    • 14907: X91159
      H. sapiens anti-mullerian hormone type II receptor exon 6
      gi|1107677|emb|X91159.1|HSAMREX06[1107677]
    • 14908: X91158
      H. sapiens anti-mullerian hormone type II receptor exon 5
      gi|1107676|emb|X91158.1|HSAMREX05[1107676]
    • 14909: X91157
      H. sapiens anti-mullerian hormone type II receptor exon 4
      gi|1107675|emb|X91157.1|HSAMREX04[1107675]
    • 14910: X91165
      H. sapiens anti-mullerian hormone type II receptor exon 3
      gi|1107674|emb|X91165.1|HSAMREX03[1107674]
    • 14911: X91166
      H. sapiens anti-mullerian hormone type II receptor exon 2
      gi|1107673|emb|X91166.1|HSAMREX02[1107673]
    • 14912: X65699
      H. sapiens mRNA for angiotensin II receptor
      gi|510983|emb|X65699.1|HSANGII[510983]
    • 14913: X91156
      H. sapiens anti-mullerian hormone type II receptor exon 1
      gi|1107671|emb|X91156.1|HSAMREX01[1107671]
    • 14914: Z22533
      H. sapiens ALK-1 mRNA
      gi|402196|emb|Z22533.1|HSALK1A[402196]
    • 14915: Z22536
      Homo sapiens ALK-4 mRNA, complete CDS
      gi|402188|emb|Z22536.1|HSALK4A[402188]
    • 14916: Z22535
      H. sapiens ALK-3 mRNA
      gi|402186|emb|Z22535.1|HSALK3A[402186]
    • 14917: Z22534
      H. sapiens ALK-2 mRNA
      gi|402184|emb|Z22534.1|HSALK2A[402184]
    • 14918: X59684
      H. sapiens DNA for alpha2-1.8 adrenergic receptor gene
      gi|28635|emb|X59684.1|HSALPH218[28635]
    • 14919: Z11687
      H. sapiens mRNA for antidiuretic hormone receptor
      gi|28417|emb|Z11687.1|HSADHRMR[28417]
    • 14920: X77533
      H. sapiens mRNA for activin type II receptor
      gi|825619|emb|X77533.1|HSACTIIRE[825619]
    • 14921: X62381
      H. sapiens mRNA for activin receptor
      gi|28347|emb|X62381.1|HSACTR[28347]
    • 14922: X65633
      H. sapiens ACTH-R gene for adrenocorticotropic hormone receptor
      gi|28343|emb|X65633.1|HSACTHR[28343]
    • 14923: X55019
      H. sapiens mRNA for acetylcholine receptor delta subunit
      gi|297401|emb|X55019.1|HSACHRG[297401]
    • 14924: X02508
      H. sapiens gene fragment for acetylcholine receptor (AChR) alpha subunit exons 8,
      9 and 3′ flanking region
      gi|28306|emb|X02508.1|HSACHR8[28306]
    • 14925: X02507
      H. sapiens gene fragment for acetylcholine receptor (AChR) alpha subunit exon 7
      gi|28304|emb|X02507.1|HSACHR7[28304]
    • 14926: X02506
      H. sapiens gene fragment for acetylcholine receptor (AChR) alpha-subunit exon 6
      gi|28302|emb|X02506.1|HSACHR6[28302]
    • 14927: X83956
      H. sapiens ACCA gene
      gi|1061125|emb|X83956.1|HSACCAGEN[1061125]
    • 14928: X66403
      H. sapiens mRNA for acetylcholine receptor (epsilon subunit)
      gi|560152|emb|X66403.1|HSACETR[560152]
    • 14929: X02505
      H. sapiens gene fragment for acetylcholine receptor (AChR) alpha subunit exon 5
      gi|28300|emb|X02505.1|HSACHR5[28300]
    • 14930: X02504
      H. sapiens gene fragment for acetylcholine receptor (AChR) alpha-subunit exon 4
      gi|28298|emb|X02504.1|HSACHR4[28298]
    • 14931: X02503
      H. sapiens gene fragment for acetylcholine receptor (AChR) alpha-subunit exons 2 and 3
      gi|28293|emb|X02503.1|HSACHR2[28293]
    • 14932: X02502
      H. sapiens gene fragment for acetylcholine receptor (AChR) alpha-subunit exon
      gi|28291|emb|X02502.1|HSACHR[28291]
    • 14933: X04759
      H. sapiens gene fragment for the acetylcholine receptor gamma subunit (exon 12)
      gi|28288|emb|X04759.1|HSACHG8[28288]
    • 14934: X01721
      H. sapiens gene fragment for the acetylcholine receptor gamma subunit (exons and 11)
      gi|28286|emb|X01721.1|HSACHG7[28286]
    • 14935: X01720
      H. sapiens gene fragment for the acetylcholine receptor gamma subunit (exon 9)
      gi|28283|emb|X01720.1|HSACHG6[28283]
    • 14936: X01718
      H. sapiens gene fragment for the acetylcholine receptor gamma subunit (exon 6)
      gi|28276|emb|X01718.1|HSACHG4[28276]
    • 14937: X01717
      H. sapiens gene fragment for the acetylcholine receptor gamma subunit (exon 5)
      gi|28274|emb|X01717.1|HSACHG3[28274]
    • 14938: X01716
      H. sapiens gene fragment for the acetylcholine receptor gamma subunit (exon 3 and
      4)
      gi|28271|emb|X01716.1|HSACHG2[28271]
    • 14939: X77018
      H. sapiens mRNA for anti-acetylcholine receptor monoclonal autoantibody V lambda
      region
      gi|441251|emb|X77018.1|HSAARMA2[441251]
    • 14941: X68487
      H. sapiens mRNA for A2b adenosine receptor
      gi|400453|emb|X68487.1|HSA2BREC[400453]
    • 14942: X68486
      H. sapiens mRNA for A2a adenosine receptor
      gi|400451|emb|X68486.1|HSA2AREC[400451]
    • 14943: X68485
      H. sapiens mRNA for A1 adenosine receptor
      gi|400449|emb|X68485.1|HSA1ADREC[400449]
    • 14948: X87197
      H. sapiens mRNA for 6.3 gene
      gi|854083|emb|X87197.1|HS63MRNAG[854083]
    • 14949: X81412
      H. sapiens DNA for 5-HT5A exon2
      gi|541777|emb|X81412.1|HS5HT5A2[541777]
    • 14950: X81411
      H. sapiens DNA for 5-HT5A exon1
      gi|541776|emb|X81411.1|HS5HT5A1[541776]
    • 14952: X77307
      H. sapiens mRNA for 5-HT2B serotonin receptor
      gi|475197|emb|X77307.1|HS5HT2BSR[475197]
    • 14968: X75299
      H. sapiens HIVR mRNA for vasoactive intestinal peptide (VIP) receptor
      gi|407461|emb|X75299.1|HSVIPRE[407461]
    • 14969: X94216
      H. sapiens mRNA for VEGF-C protein
      gi|1177488|emb|X94216.1|HSVEGFC[1177488]
    • 14971: X67482
      H. sapiens mRNA for 1,25-dihydroxyvitamin D-3 receptor
      gi|37653|emb|X67482.1|HSVD3R[37653]
    • 14976: Z46797
      H. sapiens gene for urokinase receptor (partial)
      gi|732804|emb|Z46797.1|HSUPAR5[732804]
    • 14977: X74039
      H. sapiens mRNA for urokinase plasminogen activator receptor
      gi|456192|emb|X74039.1|HSUPAR[456192]
    • 14984: X51675
      H. sapiens urokinase plasminogen activator surface receptor (UPAR) mRNA
      gi|37604|emb|X51675.1|HSUPARAA[37604]
    • 14985: X76498
      H. sapiens gene for uterine bombesin receptor
      gi|468753|emb|X76498.1|HSUBR[468753]
    • 14986: X66029
      H. sapiens mRNA for tyrosine kinase receptor
      gi|37596|emb|X66029.1|HSUFOR[37596]
    • 14987: X66030
      Homo sapiens partial ufo gene encoding tyrosine kinase receptor
      gi|37594|emb|X66030.1|HSUFOD[37594]
    • 14998: X72089
      H. sapiens mRNA for TRH receptor
      gi|440155|emb|X72089.1|HSTRHREC[440155]
    • 15005: X72018
      H. sapiens hTGR 1 mRNA
      gi|1200088|emb|X72018.1|HSTGR1[1200088]
    • 15006: X69178
      H. sapiens mRNA for thyrotropin receptor, partial
      gi|288212|emb|X69178.1|HSTHREC[288212]
    • 15007: X69177
      H. sapiens mRNA for thyrotropin receptor, partial
      gi|288211|emb|X69177.1|HSTHRE[288211]
    • 15246: X65181
      H. sapiens gene for substance P receptor (exon 5)
      gi|36640|emb|X65181.1|HSSUBP5G[36640]
    • 15247: X65180
      H. sapiens gene for substance P receptor (exon 4)
      gi|36639|emb|X65180.1|HSSUBP4G[36639]
    • 15248: X65179
      H. sapiens gene for substance P receptor (exon 3)
      gi|36638|emb|X65179.1|HSSUBP3G[36638]
    • 15249: X65177
      H. sapiens gene for substance P receptor (exon 1)
      gi|36636|emb|X65177.1|HSSUBP1G[36636]
    • 15253: X62156
      H. sapiens mRNA for soluble interleukin-5 receptor
      gi|36465|emb|X62156.1|HSSILRS[36465]
    • 15254: X57830
      H. sapiens serotonin 5-HT2 receptor mRNA
      gi|36430|emb|X57830.1|HSSERR52[36430]
    • 15255: Z11166
      H. sapiens S31 gene for serotonin receptor
      gi|36264|emb|Z11166.1|HSS31G[36264]
    • 15256: X91869
      H. sapiens mRNA for ryanodine receptor
      gi|1022320|emb|X91869.1|HSRYR2[1022320]
    • 15257: X74269
      H. sapiens RYR3 mRNA for ryanodine receptor type 3 (partial)
      gi|405718|emb|X74269.1|HSRYR3MR[405718]
    • 15258: X74270
      H. sapiens RYR3 gene for ryanodine receptor type 3 (partial)
      gi|405716|emb|X74270.1|HSRYR3G[405716]
    • 15261: Z27409
      H. sapiens mRNA for receptor tyrosine kinase eph (partial)
      gi|482916|emb|Z27409.1|HSRTKEPH[482916]
    • 15262: X74764
      H. sapiens mRNA for receptor protein tyrosine kinase
      gi|433337|emb|X74764.1|HSRPTK[433337]
    • 15265: X59155
      H. sapiens retroviral receptor mRNA
      gi|36160|emb|X59155.1|HSRRMRNA[36160]
    • 15267: X70040
      H. sapiens RON mRNA for tyrosine kinase
      gi|36109|emb|X70040.1|HSRON[36109]
    • 15268: X75071
      H. sapiens mRNA for human thyrotropin-releasing hormone receptor
      gi|404157|emb|X75071.1|HSRNAHTRH[404157]
    • 15269: X86446
      H. sapiens mRNA for 55.11 binding protein
      gi|1008088|emb|X86446.1|HSRNA5511[1008088]
    • 15270: Z29093
      H. sapiens EDDR1 gene for receptor tyrosine kinase
      gi|732799|emb|Z29093.1|HSRETYK1[732799]
    • 15274: X64123
      H. sapiens PVR gene for poliovirus receptor (exon 8)
      gi|35819|emb|X64123.1|HSPVR8G[35819]
    • 15275: X64122
      H. sapiens PVR gene for poliovirus receptor (exon 7)
      gi|35818|emb|X64122.1|HSPVR7G[35818]
    • 15276: X64121
      H. sapiens PVR gene for poliovirus receptor (exon 6)
      gi|35817|emb|X64121.1|HSPVR6G[35817]
    • 15277: X64120
      H. sapiens PVR gene for poliovirus receptor (exon 5)
      gi|35816|emb|X64120.1|HSPVR5G[35816]
    • 15278: X64119
      H. sapiens PVR gene for poliovirus receptor (exon 4)
      gi|35815|emb|X64119.1|HSPVR4G[35815]
    • 15279: X64118
      H. sapiens PVR gene for poliovirus receptor (exon 3)
      gi|35814|emb|X64118.1|HSPVR3G[35814]
    • 15280: X64117
      H. sapiens PVR gene for poliovirus receptor (exon 2)
      gi|35813|emb|X64117.1|HSPVR2G[35813]
    • 15281: X64116
      H. sapiens PVR gene for poliovirus receptor (exon 1)
      gi|35809|emb|X64116.1|HSPVR1G[35809]
    • 15283: X75208
      H. sapiens HEK2 mRNA for protein tyrosine kinase receptor
      gi|406867|emb|X75208.1|HSPTKR[406867]
    • 15284: X65178
      H. sapiens gene for substance P receptor (exon 2)
      gi|35653|emb|X65178.1|HSPREC2G[35653]
    • 15285: X94226
      H. sapiens poliovirus receptor gene
      gi|1185121|emb|X94226.1|HSPOLR[1185121]
    • 15288: X73079
      Homo sapiens encoding Polymeric immunoglobulin receptor
      gi|456345|emb|X73079.1|HSPIR[456345]
    • 15291: X68596
      H. sapiens mRNA for parathyroid hormone receptor
      gi|396812|emb|X68596.1|HSPHR[396812]
    • 15302: X76079
      H. sapiens mRNA for platelet derived growth factor alpha receptor
      gi|433494|emb|X76079.1|HSPDGF[433494]
    • 15311: Z49993
      H. sapiens partial gene for proteinase-activated receptor 2 (292 BP)
      gi|1008084|emb|Z49993.1|HSPAR2A[1008084]
    • 15321: X80022
      H. sapiens p75 TNF receptor, exon 2
      gi|666045|emb|X80022.1|HSP75NFR2[666045]
    • 15322: X80021
      H. sapiens p75 TNF receptor, exon 1
      gi|666044|emb|X80021.1|HSP75NFR1[666044]
    • 15323: X69810
      H. sapiens gene for p55 tumor necrosis factor receptor, exon 1
      gi|288493|emb|X69810.1|HSP55TNF[288493]
    • 15324: X83688
      H. sapiens mRNA for ATP receptor
      gi|1166437|emb|X83688.1|HSP2XRCPR[1166437]
    • 15325: X77130
      H. sapiens mRNA for ORL1 receptor
      gi|471316|emb|X77130.1|HSORL1[471316]
    • 15327: X71635
      H. sapiens mRNA for neuropeptide Y-like receptor
      gi|297099|emb|X71635.1|HSNPYRLA[297099]
    • 15328: X71445
      H. sapiens partial NTRK1 gene, involved in oncogenic rearrangements
      gi|296536|emb|X71445.1|HSNTRK1[296536]
    • 15329: X66945
      H. sapiens N-sam mRNA for fibroblast growth factor receptor
      gi|35109|emb|X66945.1|HSNSAMTK[35109]
    • 15330: X75918
      H. sapiens mRNA for NOT
      gi|415822|emb|X75918.1|HSNOT[415822]
    • 15331: Z32774
      H. sapiens gene for N-methyl-D-aspartate receptor R1 exons 6-21
      gi|807894|emb|Z32774.1|HSNMDAR1C[807894]
    • 15332: Z32773
      H. sapiens gene for N-methyl-D-aspartate receptor R1 exons 3, 4, 5
      gi|807893|emb|Z32773.1|HSNMDAR1B[807893]
    • 15333: Z32772
      H. sapiens gene for N-methyl-D-aspartate receptor R1, exon1, exon2
      gi|807892|emb|Z32772.1|HSNMDAR1A[807892]
    • 15334: X68275
      H. sapiens mRNA for nicotinic receptor beta 4 subunit
      gi|35054|emb|X68275.1|HSNICRB[35054]
    • 15335: X65176
      H. sapiens gene for neuromedin K receptor (exon 5)
      gi|35027|emb|X65176.1|HSNEURK5[35027]
    • 15336: X65175
      H. sapiens gene for neuromedin K receptor (exon 4)
      gi|35026|emb|X65175.1|HSNEURK4[35026]
    • 15337: X65174
      H. sapiens gene for neuromedin K receptor (exon 3)
      gi|35025|emb|X65174.1|HSNEURK3[35025]
    • 15338: X65173
      H. sapiens gene for neuromedin K receptor (exon 2)
      gi|35024|emb|X65173.1|HSNEURK2[35024]
    • 15339: X65172
      H. sapiens gene for neuromedin K receptor (exon 1)
      gi|35022|emb|X65172.1|HSNEURK1[35022]
    • 15340: X87629
      H. sapiens mRNA for nicotinic acetylcholine receptor alpha4 subunit
      gi|854158|emb|X87629.1|HSNACRA4G[854158]
    • 15341: X70108
      H. sapiens gene for nicotinic acetylcholine receptor alpha subunit, partial
      gi|312470|emb|X70108.1|HSNACHRA[312470]
    • 15342: X67513
      H. sapiens mRNA for neuronal nAChR beta-3 subunit
      gi|34987|emb|X67513.1|HSNACHRB3[34987]
    • 15343: X53559
      H. sapiens Hachr alpha-3 mRNA for mature neuronal nicotinic acetylcholine receptor alpha-3 subunit
      gi|34985|emb|X53559.1|HSNACHRA3[34985]
    • 15344: X63131
      H. sapiens My1 (PML) mRNA
      gi|34813|emb|X63131.1|HSMY1[34813]
    • 15345: X65634
      H. sapiens MSH-R gene for melanocyte stimulating hormone receptor
      gi|34790|emb|X65634.1HSMSHR[34790]
    • 15346: X64878
      H. sapiens mRNA for oxytocin receptor
      gi|34764|emb|X64878.1|HSMRNAOXY[34764]
    • 15347: X84709
      H. sapiens mRNA for mediator of receptor-induced toxicity
      gi|791037|emb|X84709.1|HSMRINTX[791037]
    • 15348: X55635
      H. sapiens mRNA for macrophage mannose receptor
      gi|34702|emb|X55635.1|HSMMR[34702]
    • 15349: Z25470
      H. sapiens melanocortin 5 receptor gene, complete CDS
      gi|939924|emb|Z25470.1|HSMELRECA[939924]
    • 15350: X68829
      H. sapiens mRNA for MDR15 protein
      gi|840783|emb|X68829.1|HSMDCR[840783]
    • 15351: X61615
      H. sapiens mRNA for leukemia inhibitory factor (LIF) receptor
      gi|34365|emb|X61615.1|HSLIFR[34365]
    • 15374: X86128
      H. sapiens mRNA for ood T lymphocyte
      gi|1197254|emb|X86128.1|HSLAB2725[1197254]
    • 15375: Z30428
      H. sapiens gene for early lymphocyte activation antigen CD69, exon 5
      gi|536775|emb|Z30428.1|HSLACD695[536775]
    • 15376: Z30430
      H. sapiens gene for early lymphocyte activation antigen CD69, exon 2
      gi|535122|emb|Z30430.1|HSLACD692[535122]
    • 15398: X69304
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 4
      gi|34093|emb|X69304.1HSKITPO04[34093]
    • 15399: X69303
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 3
      gi|34092|emb|X69303.1|HSKITPO03[34092]
    • 15400: X69302
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 2
      gi|34091|emb|X69302.1|HSKITPO02[34091]
    • 15401: X69301
      H. sapiens KIT proto-oncogene for mast/stem cell growth factor receptor, exon 1
      gi|34089|emb|X69301.1|HSKITPO01[34089]
    • 15405: X03138
      H. sapiens interleukin 2 receptor gene exon 8 and 3′ untranslated region
      gi|33830|emb|X03138.1|HSIL2RG8[33830]
    • 15406: X03137
      H. sapiens interleukin 2 receptor gene exon 7
      gi|33829|emb|X03137.1|HSIL2RG7[33829]
    • 15407: X03136
      H. sapiens interleukin 2 receptor gene exon 6
      gi|33827|emb|X03136.1|HSIL2RG6[33827]
    • 15408: X03135
      H. sapiens interleukin 2 receptor gene exon 5
      gi|33825|emb|X03135.1|HSIL2RG5[33825]
    • 15409: X03134
      H. sapiens interleukin 2 receptor gene exon 4
      gi|33823|emb|X03134.1|HSIL2RG4[33823]
    • 15410: X03133
      H. sapiens interleukin 2 receptor gene exon 3
      gi|33822|emb|X03133.1|HSIL2RG3[33822]
    • 15411: X03132
      H. sapiens interleukin 2 receptor gene exon 2
      gi|33820|emb|X03132.1|HSIL2RG2[33820]
    • 15412: X84348
      H. sapiens mRNA for intracellular IL-1 receptor antagonist type II
      gi|1008970|emb|X84348.1|HSIL1RAII[1008970]
    • 15413: Z46595
      H. sapiens mRNA for interleukin 11 receptor isoform (incomplete)
      gi|995655|emb|Z46595.1|HSIL11RR[995655]
    • 15414: Z38102
      H. sapiens mRNA for interleukin-11 receptor
      gi|995653|emb|Z38102.1|HSIL11RM[995653]
    • 15415: Z46596
      H. sapiens gene for interleukin 11 receptor
      gi|995652|emb|Z46596.1|HSIL11RGN[995652]
    • 15416: X59770
      H. sapiens IL-1R2 mRNA for type II interleukin-1 receptor, (cell line CB23)
      gi|33796|emb|X59770.1|HSIL1R211[33796]
    • 15421: X77722
      H. sapiens mRNA for interferon alpha/beta receptor
      gi|488363|emb|X77722.1|HSIFNABR[488363]
    • 15423: X53296
      H. sapiens mRNA for IRAP
      gi|32578|emb|X53296.1|HSI1RAP[32578]
    • 15424: X52015
      H. sapiens mRNA for interleukin-1 receptor antagonist
      gi|32576|emb|X52015.1|HSI1RA[32576]
    • 15425: X64993
      H. sapiens mRNA HTPCRX19 for olfactory receptor
      gi|32523|emb|X64993.1|HSHTPRX19[32523]
    • 15426: X64992
      H. sapiens mRNA HTPCRX18 for olfactory receptor
      gi|32522|emb|X64992.1|HSHTPRX18[32522]
    • 15427: X64991
      H. sapiens mRNA HTPCRX17 for olfactory receptor
      gi|32521|emb|X64991.1|HSHTPRX17[32521]
    • 15428: X64990
      H. sapiens mRNA HTPCRX16 for olfactory receptor
      gi|32520|emb|X64990.1|HSHTPRX16[32520]
    • 15429: X64989
      H. sapiens mRNA HTPCRX15 for olfactory receptor
      gi|32519|emb|X64989.1|HSHTPRX15[32519]
    • 15430: X64988
      H. sapiens mRNA HTPCRX14 for olfactory receptor
      gi|32518|emb|X64988.1|HSHTPRX14[32518]
    • 15431: X64987
      H. sapiens mRNA HTPCRX13 for olfactory receptor
      gi|32517|emb|X64987.1|HSHTPRX13[32517]
    • 15432: X64986
      H. sapiens mRNA HTPCRX12 for olfactory receptor
      gi|32516|emb|X64986.1|HSHTPRX12[32516]
    • 15433: X64985
      H. sapiens mRNA HTPCRX11 for olfactory receptor
      gi|32515|emb|X64985.1|HSHTPRX11[32515]
    • 15434: X64984
      H. sapiens mRNA HTPCRX10 for olfactory receptor
      gi|32514|emb|X64984.1|HSHTPRX10[32514]
    • 15435: X64983
      H. sapiens mRNA HTPCRX09 for olfactory receptor
      gi|32513|emb|X64983.1|HSHTPRX09[32513]
    • 15436: X64982
      H. sapiens mRNA HTPCRX06 for olfactory receptor
      gi|32512|emb|X64982.1|HSHTPRX06[32512]
    • 15437: X64981
      H. sapiens mRNA HTPCRX03 for olfactory receptor
      gi|32511|emb|X64981.1|HSHTPRX03[32511]
    • 15438: X64980
      H. sapiens mRNA HTPCRX02 for olfactory receptor
      gi|32510|emb|X64Y80.1|HSHTPRX02[32510]
    • 15439: X64979
      H. sapiens mRNA HTPCRX01 for olfactory receptor
      gi|32509|emb|X64979.1|HSHTPRX01[32509]
    • 15440: X64974
      H. sapiens mRNA HTPCRH02 for olfactory receptor
      gi|32508|emb|X64974.1|HSHTPRH02[32508]
    • 15441: X64978
      H. sapiens mRNA HTPCRH07 for olfactory receptor
      gi|32507|emb|X64978.1|HSHTPRH07[32507]
    • 15442: X64977
      H. sapiens mRNA HTPCRH06 for olfactory receptor
      gi|32506|emb|X64977.1|HSHTPRH06[32506]
    • 15443: X64976
      H. sapiens mRNA HTPCRH04 for olfactory receptor
      gi|32505|emb|X64976.1|HSHTPRH04[32505]
    • 15444: X64975
      H. sapiens mRNA HTPCRH03 for olfactory receptor
      gi|32504|emb|X64975.1|HSHTPRH03[32504]
    • 15445: X58288
      H. sapiens hR-PTPu gene for protein tyrosine phosphatase
      gi|32455|emb|X58288.1|HSHRPTPU[32455]
    • 15449: X64995
      H. sapiens HGMP07J gene for olfactory receptor
      gi|32092|emb|X64995.1|HSHGMP07J[32092]
    • 15450: X64994
      H. sapiens HGMP07I gene for olfactory receptor
      gi|32085|emb|X64994.1|HSHGM071[32085]
    • 15451: X17653
      H. sapiens hFcRII-C isoform mRNA for IgG Fc receptor hFcRII
      gi|32076|emb|X17653.1|HSHFCRIIC[32076]
    • 15452: X17652
      H. sapiens hFcRII-B isoform mRNA for IgG Fc receptor hFcRII
      gi|32073|emb|X17652.1|HSHFCRIIB[32073]
    • 15453: X53364
      H. sapiens HePTP mRNA for tyrosine phosphatase
      gi|32066|emb|X53364.1|HSHEPTP[32066]
    • 15454: X64830
      H. sapiens mRNA for GLU-R2 glutamate receptor subunit, ‘flop’ exon
      gi|31911|emb|X64830.1|HSGRSFLOP[31911]
    • 15455: X64829
      H. sapiens mRNA for GLU-R2 glutamate receptor subunit, ‘flip’ exon
      gi|31910|emb|X64829.1|HSGRSFLIP[31910]
    • 15456: X75897
      H. sapiens mRNA for G-protein coupled kinase 4
      gi|483764|emb|X75897.1|HSGRK4[483764]
    • 15460: X52009
      H. sapiens alpha-1 strychnine binding subunit of inhibitory glycine receptor mRNA
      gi|3185|emb|X52009.1|HSGLYRA2[31850]
    • 15461: X52008
      H. sapiens alpha-2 strychnine binding subunit of inhibitory glycine receptor mRNA
      gi|31848|emb|X52008.1|HSGLYRA1[31848]
    • 15462: X82068
      H. sapiens mRNA for glutamate receptor subunit GluRC
      gi|558587|emb|X82068.1|HSGLURC[558587]
    • 15463: X58633
      H. sapiens mRNA for glutamate receptor GLUR1
      gi|414892|emb|X58633.1|HSGLUR1[414892]
    • 15464: X81832
      H. sapiens mRNA for glucose-dependant insulinotropic polypeptide receptor gene
      gi|11030050 emb|X81832.1|HSGDIPR[1030050]
    • 15465: X61656
      H. sapiens mRNA for growth factor receptor tyrosine kinase
      gi|31717|emb|X61656.1|HSGFRTK[31717]
    • 15466: X55037
      H. sapiens GATA-3 mRNA
      gi|31661|emb|X55037.1|HSGATA3[31661]
    • 15467: X63670
      H. sapiens DNA sequence for polymorphism at the GABA receptor B3
      gi|31638|emb|X63670.1|HSGABRB3[31638]
    • 15472: Z34260
      H. sapiens DNA for follicle stimulating hormone (FSH) receptor
      gi|1052701|emb|Z34260.1|HSFSHX1[1052701]
    • 15473: X68044
      H. sapiens mRNA for follicle-stimulating hormone receptor
      gi|31473|emb|X68044.1|HSFSTHR[31473]
    • 15474: Z46619
      H. sapiens mRNA for immunoglobulin kappa chain (fsa10)
      gi|575235|emb|Z46619.1|HSFSA10KA[575235]
    • 15475: Z46615
      H. sapiens DNA for immunoglobulin kappa chain (fsa10glk)
      gi|575234|emb|Z46615.1|HSFSA10GL[575234]
    • 15476: Z32633
      H. sapiens FRGAMMA′ mRNA for folate receptor (817 bp)
      gi|474060|emb|Z32633.1|HSFRGAM2[474060]
    • 15477: Z32564
      H. sapiens FRGAMMA mRNA (819 bp) for folate receptor
      gi|473235|emb|Z32564.1|HSFRGAM1[473235]
    • 15478: X69878
      H. sapiens Flt4 mRNA for transmembrane tyrosine kinase
      gi|297049|emb|X69878.1|HSFLT4X[297049]
    • 15479: X68203
      H. sapiens mRNA for FLT4, class III receptor tyrosine kinase
      gi|31433|emb|X68203.1|HSFLT4[31433]
    • 15480: X62573
      H. sapiens RNA for Fc receptor, TC9
      gi|31339|emb|X62573.1|HSFCTC6[31339]
    • 15481: X66187
      H. sapiens FceRI mRNA, partial CDS
      gi|396463|emb|X66187.1|HSFCERIGB[396463]
    • 15482: X62572
      H. sapiens RNA for Fc receptor, PC23
      gi|31328|emb|X62572.1|HSFCPC23[31328]
    • 15483: Z46618
      H. sapiens mRNA for immunoglobulin lambda chain (f29)
      gi|575230|emb|Z46618.1|HSF29LAM[575230]
    • 15484: Z46634
      H. sapiens mRNA for immunoglobulin kappa chain (f29)
      gi|575228|emb|Z46634.1|HSF29KAP[575228]
    • 15485: X61950
      H. sapiens mRNA for endothelin-1 receptor
      gi|288312|emb|X61950.1|HSET1R[288312]
    • 15486: X83863
      H. sapiens mRNA for prostaglandin E receptor (EP3f)
      gi|633219|emb|X83863.1|HSEP3F[633219]
    • 15487: X83862
      H. sapiens mRNA for prostaglandin E receptor (EP3e)
      gi|633217|emb|X83862.1|HSEP3E[633217]
    • 15488: X83861
      H. sapiens mRNA for prostaglandin E receptor (EP3d)
      gi|633215|emb|X83861.1|HSEP3D[633215]
    • 15489: X83860
      H. sapiens mRNA for prostaglandin E receptor (EP3c)
      gi|633213|emb|X83860.1|HSEP3C[633213]
    • 15490: X83859
      H. sapiens mRNA for prostaglandin E receptor (EP3b)
      gi|633211|emb|X83859.1|HSEP3B[633211]
    • 15491: X83858
      H. sapiens mRNA for prostaglandin E receptor (EP3a2)
      gi|633209|emb|X83858.1|HSEP3A2[633209]
    • 15492: X83857
      H. sapiens mRNA for prostaglandin E receptor (EP3a1)
      gi|633207|emb|X83857.1HSEP3A1[633207]
    • 15493: X83868
      H. sapiens mRNA for EP2 prostaglandin receptor
      gi|633205|emb|X83868.1|HSEP2PR[633205]
    • 15494: X81479
      H. sapiens mRNA for EMR1 hormone receptor
      gi|784993|emb|X81479.1|HSEMR1[784993]
    • 15518: Z28613
      H. sapiens (dhpa215) cacnl2a gene for dihydropyridine receptor alpha-2 subunit
      gi|472953|emb|Z28613.1|HSDPRA25[472953]
    • 15519: Z28609
      H. sapiens (dhpa22hd) cacnl2a gene for dihydropyridine receptor alpha 2-subunit
      gi|472952|emb|Z28609.1|HSDPRA24[472952]
    • 15520: Z28605
      H. sapiens (dhpa23) cacnl2a gene for dihydropyridine receptor alpha2 subunit
      gi|472951|emb|Z28605.1|HSDPRA23[472951]
    • 15521: Z28602
      H. sapiens (dhpa21hb) cacnl2a gene for dihydropyridine receptor alpha 2-subunit
      gi|472950|emb|Z28602.1|HSDPRA22[472950]
    • 15522: Z28599
      H. sapiens (a225eh) cacnl2a gene for dihydropyridine receptor alpha2 subunit
      gi|472949|emb|Z28599.1|HSDPRA21[472949]
    • 15526: X55758
      H. sapiens dopamine D1 receptor gene
      gi|288931|emb|X55758.1|HSDOPD1[288931]
    • 15529: Z23025
      H. sapiens cacnl1a3 gene encoding skeletal muscle DHP-receptor alpha 1 subunit (exon)
      gi|312285|emb|Z23025.1|HSDHPRA1S[312285]
    • 15530: X84076
      H. sapiens mRNA for DGCR2
      gi|80902|emb|X84076.1|HSDGCR2[809021]
    • 15532: X63523
      H. sapiens mRNA DAUD16 3′-region
      gi|30449|emb|X63523.1|HSDAUDI63[30449]
    • 15533: X66171
      H. sapiens CMRF35 mRNA, complete CDS
      gi|396169|emb|X66171.1|HSCMRF35A[396169]
    • 15534: Z23141
      H. sapiens CHRNA7 mRNA, 3′ end
      gi|457736|emb|Z23141.1|HSCHRNA7A[457736]
    • 15550: X56777
      H. sapiens mRNA for ZP3 gene
      gi|297790|emb|X56777.1|HSZP3G[297790]
    • 15551: X77155
      H. sapiens genomic DNA (YAC end 63 with high affinity Fc-receptor for IgG)
      gi|450533|emb|X77155.1|HSYACFC[450533]
    • 15582: M31165
      Human tumor necrosis factor-inducible (TSG-6) mRNA fragment, adhesion receptor
      CD44 putative CDS
      gi|339994|gb|M31165.1|HUMTSG6A[339994]
    • 15594: A31613
      H. sapiens beta-adrenergic receptor gene
      gi|1247565|emb|A31613.1|A31613[1247565]
    • 15595: A29216
      H. sapiens DNA for bFGF receptor from patent WO9111459
      gi|1247528|emb|A29216.1|A29216[1247528]
    • 15596: A29103
      H. sapiens mRNA for TNF-binding polypeptide from patent EP0393438
      gi|1247517|emb|A29103.1|A29103[1247517]
    • 15597: A28489
      H. sapiens mRNA for IL-2R-beta-chain from patent EP0395853
      gi|1247509|emb|A28489.1|A28489[1247509]
    • 15598: A28003
      H. sapiens HEK gene
      gi|1247486|emb|A28003.1|A28003[1247486]
    • 15599: A27284
      H. sapiens TGR-CLH
      gi|1247482|emb|A27284.1|A27284[1247482]
    • 15600: A27280
      H. sapiens TGR-CL3
      gi|1247480|emb|A27280.1|A27280[1247480]
    • 15601: A27274
      H. sapiens TGR-CL11/TGR-C15
      gi|1247478|emb|A27274.1|A27274[1247478]
    • 15602: A27272
      H. sapiens TGR-CL11
      gi|1247476|emb|A27272.1|A27272[1247476]
    • 15603: A27268
      H. sapiens TGR-CL10
      gi|1247474|emb|A27268.1|A27268[1247474]
    • 15604: A27266
      H. sapiens TGR-CL7
      gi|1247472|emb|A27266.1|A27266[1247472]
    • 15605: A27264
      H. sapiens TGR-CL6
      gi|1247470|emb|A27264.1|A27264[1247470]
    • 15606: A27262
      H. sapiens TGR-CL5bis
      gi|1247468|emb|A27262.1|A27262[1247468]
    • 15607: A27260
      H. sapiens TGR-CL4
      gi|1247466|emb|A27260.1|A27260[1247466]
    • 15608: A27258
      H. sapiens TGR-CL1bis
      gi|1247464|emb|A27258.1|A27258[1247464]
    • 15609: A19671
      H. sapiens DNA for D3 receptor fragment
      gi|579581|emb|A19671.1|A19671[579581]
    • 15610: A19670
      H. sapiens DNA for D3 receptor fragment
      gi|579580|emb|A19670.1|A19670[579580]
    • 15611: A19667
      H. sapiens gene for dopaminergic receptor D-3
      gi|579578|emb|A19667.1|A19667[579578]
    • 15612: A09781
      H. sapiens (clone 18-4-3) mRNA interferon-gamma receptor segment
      gi|412192|emb|A09781.1|A09781[412192]
    • 15613: A09779
      H. sapiens (clone 15-21-1) mRNA for interferon-gamma receptor segment binding interferon-gamma
      gi|412190|emb|A09779.1|A09779[412190]
    • 15614: A07799
      H. sapiens IL-2R-beta mRNA for interleukin-2 beta-chain
      gi|1247399|emb|A07799.1|A07799[1247399]
    • 15615: A07801
      H. sapiens IL-2R-beta mRNA for interleukin-2 beta-chain
      gi|490067|emb|A07801.1|A07801[490067]
    • 15616: A07795
      H. sapiens IL-2R-beta mRNA for interleukin-2 receptor beta-chain
      gi|412175|emb|A07795.1|A07795[412175]
    • 15617: L11573
      Human surfactant protein B mRNA, complete cds
      gi|1220354|gb|L11573.1|HUMPSPBQ[1220354]
    • 15618: L40625
      Homo sapiens sulfonylurea receptor (SUR) mRNA, 3′ end of cds
      gi|784881|gb|L40625.1|HUMSUR[784881]
    • 15620: L34579
      Homo sapiens (clone HCl) angiotensin II type-2 receptor (AGTR2) gene, complete
      cds
      gi|510700|gb|L34579.1|HUMAIRS[510700]
    • 15621: X97058
      H. sapiens mRNA for P2Y6 receptor
      gi|1296659|emb|X97058.1|HSP2Y6[1296659]
    • 15622: X96588
      H. sapiens mRNA for H-RYK receptor tyrosine kinase
      gi|1296649|emb|X96588.1|HSHRYKG[1296649]
    • 15623: X80391
      H. sapiens OR17-40 gene
      gi|516319|emb|X80391.1|HSOR1740[516319]
    • 15624: L41690
      Homo sapiens TNF receptor-1 associated protein (TRADD) mRNA, 3′ end of cds
      gi|808914|gb|L41690.1|HUMTRADD[808914]
    • 15630: X89746
      H. sapiens mRNA for neuronal acetylcholine receptor alpha-4 subunit, exon 6
      gi|1279464|emb|X89746.1|HSCHRNA46[1279464]
    • 15631: X89745
      H. sapiens mRNA for neuronal acetylcholine receptor alpha-4 subunit, exon 5
      gi|1279463|emb|X89745.1|HSCHRNA45[1279463]
    • 15632: X89743
      H. sapiens mRNA for neuronal acetylcholine receptor alpha-4 subunit, exon 3
      gi|1279461|emb|X89743.1|HSCHRNA43[1279461]
    • 15633: X89742
      H. sapiens mRNA for neuronal acetylcholine receptor alpha-4 subunit, exon 2
      gi|1279460|emb|X89742.1|HSCHRNA42[1279460]
    • 15634: X89741
      H. sapiens mRNA for neuronal acetylcholine receptor alpha-4 subunit, exon 1
      gi|1279458|emb|X89741.1|HSCHRNA41[1279458]
    • 15644: M21574
      Human platelet-derived growth factor receptor alpha (PDGFRA) mRNA, complete cds
      gi|189733|gb|M21574.1|HUMPDGFRAA[189733]
    • 15645: X94635
      H. sapiens CD97 gene exon 8
      gi|4379070|emb|X94635.1|HSX94635[4379070]
    • 15646: X94638
      H. sapiens CD97 gene exon 11
      gi|165091|emb|X94638.1|HSX94638[1165091]
    • 15647: X94637
      H. sapiens CD97 gene exon 10
      gi|1165090|emb|X94637.1|HSX94637[1165090]
    • 15648: X94636
      H. sapiens CD97 gene exon 9
      gi|1165089|emb|X94636.1|HSX94636[1165089]
    • 15649: X94631
      H. sapiens CD97 gene exon 2
      gi|1165084|emb|X94631.1|HSX94631[1165084]
    • 15650: X94646
      H. sapiens CD97 gene exon 19
      gi|1165082|emb|X94646.1|HSX94646[1165082]
    • 15651: X94645
      H. sapiens CD97 gene exon 18
      gi|1165081|emb|X94645.1|HSX94645[1165081]
    • 15652: X94644
      H. sapiens CD97 gene exon 17
      gi|1165080|emb|X94644.1|HSX94644[1165080]
    • 15653: X94643
      H. sapiens CD97 gene exon 16
      gi|1165079|emb|X94643.1|HSX94643[1165079]
    • 15654: X94642
      H. sapiens CD97 gene exon 15
      gi|1165078|emb|X94642.1|HSX94642[1165078]
    • 15655: X94641
      H. sapiens CD97 gene exon 14
      gi|1165077|emb|X94641.1|HSX94641[1165077]
    • 15656: X94640
      H. sapiens CD97 gene exon 13
      gi|1165076|emb|X94640.1|HSX94640[1165076]
    • 15657: X94639
      H. sapiens CD97 gene exon 12
      gi|1165075|emb|X94639.1|HSX94639[1165075]
    • 15658: L40949
      Homo sapiens (clone AT7-5eu) opioid-receptor-like protein mRNA, 5′ end
      gi|725265|gb|L40949.1|HUMOPRLP[725265]
    • 15659: X57282
      H. sapiens mRNA for soluble erythropoietin receptor
      gi|36426|emb|X57282.1|HSSER[36426]
    • 15660: Z66526
      H. sapiens pancreatic polypeptide receptor PP1 gene
      gi|1107699|emb|Z66526.1|HSPP1GN[1107699]
    • 15661: X89013
      H. sapiens gene for anti-mullerian hormone type II receptor
      gi|1212943|emb|X89013.1|HSDNAAMHI[1212943]
    • 15662: X86163
      H. sapiens mRNA for B2-bradykinin receptor, 3′
      gi|1220163|emb|X86163.1|HSB2BRRNA[1220163]
    • 15663: X86165
      H. sapiens mRNA for B2-bradykinin receptor, R14 allele
      gi|1220160|emb|X86165.1|HSB2BRR14[1220160]
    • 15664: X86164
      H. sapiens mRNA for B2-bradykinin receptor, C14 allele
      gi|1220155|emb|X86164.1|HSB2BRC14[1220155]
    • 15665: L08187
      Human cytokine receptor (EBI3) mRNA, complete cds
      gi|632973|gb|L08187.1|HUMEBI3X[632973]
    • 15666: L41147
      Homo sapiens 5-HT6 serotonin receptor mRNA, complete cds
      gi|1162923|gb|L41147.1|HUM5HSR[1162923]
    • 15698: X84755
      H. sapiens LHCGR gene, exon 3
      gi|1225986|emb|X84755.1|HSLHCGRX3[1225986]
    • 15699: L25829
      Human platelet-derived growth factor alpha-receptor (PDGFRA) mRNA, exons 13-gi|1220351|gb|L25829.1|HUMPDGFRAX[1220351]
    • 15700: L07746
      Human cholecystokinin B receptor (CCK-B) mRNA, complete cds
      gi|1220298|gb|L07746.1|HUMCCKBR[1220298]
    • 15701: X86172
      H. sapiens B2-bradykinin receptor gene, exon 3, allele R48
      gi|220162|emb|X86172.1|HSB2BRR48[1220162]
    • 15702: X86180
      H. sapiens B2-bradykinin receptor gene, promoter region and exon 1
      gi|1220159|emb|X86180.1|HSB2BRPX1[1220159]
    • 15703: X86173
      H. sapiens B2-bradykinin receptor gene, promotor region and exon 1
      gi|220158|emb|X86173.1|HSB2BREX11[1220158]
    • 15704: X86162
      H. sapiens B2-bradykinin receptor gene, 3′
      gi|1220157|emb|X86162.1|HSB2BRDNA[1220157]
    • 15705: X86171
      H. sapiens B2-bradykinin receptor gene, exon 3, BE3-R43 allele
      gi|1220154|emb|X86171.1|HSB2BRBE3[1220154]
    • 15706: X86170
      H. sapiens B2-bradykinin receptor gene, exon 2, T allele
      gi|1220153|emb|X86170.1|HSB2BRAXT[1220153]
    • 15707: X86168
      H. sapiens B2-bradykinin receptor gene, exon 1, 3T allele
      gi|1220152|emb|X86168.1|HSB2BR3T[1220152]
    • 15708: X86167
      H. sapiens B2-bradykinin receptor gene, exon 1, 3G allele
      gi|1220151|emb|X86167.1|HSB2BR3G[1220151]
    • 15709: X86166
      H. sapiens B2-bradykinin receptor gene, exon 1, 2G allele
      gi|1220150|emb|X86166.1|HSB2BR2G[1220150]
    • 15710: Z69891
      H. sapiens mRNA (clone ICRFp507G10101)
      gi|1213610|emb|Z69891.1|HSBRN3B2[1213610]
    • 15711: L18983
      Homo sapiens tyrosine phosphatase (IA-2/PTP) mRNA, complete cds
      gi|662362|gb|L18983.1|HUMTYROPHO[662362]
    • 15712: L76224
      Homo sapiens NMDA receptor mRNA, complete cds
      gi|1196448|gb|L76224.1|HUMNMRE[1196448]
    • 15715: M73481
      Human gastrin releasing peptide receptor (GRPR) mRNA, complete cds
      gi|183649|gb|M73481.1|HUMGRPR[183649]
    • 15717: M30625
      Human dopamine D2 receptor, mRNA, complete cds
      gi|181431|gb|M30625.1|HUMD2A[181431]
    • 15718: J02960
      Human beta-2-adrenergic receptor gene, complete cds
      gi|178203|gb|J02960.1|HUMADRBRA[178203]
    • 15719: M15169
      Human beta-2-adrenergic receptor mRNA, complete cds
    • 15720: L18973
      Human acetylcholine receptor mRNA, partial cds
      gi|441143|gb|L18973.1|HUMACETYL[441143]
    • 15723: M73969
      Human interleukin-8 receptor type B (IL8RB) mRNA, complete cds
      gi|186516|gb|M73969.1|HUMINTLEU8[186516]
    • 15752: L35233
      Homo sapiens autocrine motility factor receptor (AMFR) mRNA, complete cds
      gi|521220|gb|L35233.1|HUMNGP78A[521220]
    • 15754: U35399
      Human G protein-coupled receptor mRNA, complete cds
      gi|1015420|gb|U35399.1|HSU35399[1015420]
    • 15755: L35318
      Human rearranged metabotropic glutamate receptor type II (GLUR2) mRNA, complete
      cds
      gi|999415|gb|L35318.1|HUMGLUR2A[999415]
    • 15756: M11730
      Human tyrosine kinase-type receptor (HER2) mRNA, complete cds
      gi|183986|gb|M11730.1|HUMHER2A[183986]
    • 15759: U33017
      Human signaling lymphocytic activation molecule (SLAM) mRNA, complete cds
      gi|984968|gb|U33017.1|HSU33017[984968]
    • 15761: L47220
      Homo sapiens inositol triphosphate receptor type 1 gene fragment
      gi|976275|gb|L47220.1|HUMITRT1F[976275]
    • 15762: M37722
      Human shorter form basic fibroblast growth factor (bFGF) receptor mRNA, complete
      cds
      gi|179413|gb|M37722.1|HUMBFGFS[179413]
    • 15765: L09753
      Homo sapiens CD30 ligand mRNA, complete cds
      gi|349277|gb|L09753.1|HUMCD30[349277]
    • 15767: L36645
      Homo sapiens receptor protein-tyrosine kinase (HEK8) mRNA, complete cds
      gi|551613|gb|L36645.1|HUMRPTKC[551613]
    • 15768: L36644
      Homo sapiens receptor protein-tyrosine kinase (HEK7) mRNA, 3′ end
      gi|551611|gb|L36644.1|HUMRPTKB[551611]
    • 15769: L36643
      Homo sapiens receptor protein-tyrosine kinase (HEK5) mRNA, 3′ end
      gi|551609|gb|L36643.1|HUMRPTKA[551609]
    • 15770: L36642
      Homo sapiens receptor protein-tyrosine kinase (HEK11) mRNA, complete cds
      gi|551607|gb|L36642.1|HUMRPTK[551607]
    • 15771: L31581
      Human G protein-coupled receptor (EBI 1) mRNA, complete cds
      gi|468319|gb|L31581.1|HUMEBI1CDN[468319]
    • 15772: L29301
      Homo sapiens opioid receptor mRNA, complete cds
      gi|459831|gb|L29301.1|HUMOPIOIDA[459831]
    • 15773: L32831
      Homo sapiens G protein-coupled receptor (GPR3) gene, complete cds
      gi|602311|gb|L32831.1|HUMGPCRD[602311]
    • 15774: L32830
      Homo sapiens G protein-coupled receptor (GPR3) gene, exon
      gi|602310|gb|L32830.1|HUMGPCRC[602310]
    • 15775: M88461
      Human neuropeptide Y peptide YY receptor mRNA, complete cds
      gi|189155|gb|M88461.1|HUMNEYPEPY[189155]
    • 15779: M73747
      Homo sapiens thyroid stimulating hormone receptor (TSHR) mRNA, complete cds
      gi|903759|gb|M73747.1|HUMTSHR[903759]
    • 15780: M73746
      Homo sapiens lutropin/choriogonadotropin receptor (LHCGR) mRNA, complete cds
      gi|903745|gb|M73746.1|HUMLHCGR[903745]
    • 15781: M90103
      Human (clones 18, 23, 27, 24) c-myeloproliferative leukemia virus type K (c-mpl-K) mRNA, complete cds
      gi|184262|gb|M90103.1|HSHMPLK[184262]
    • 15782: M90102
      Human (clones 15, 39, 41) c-myeloproliferative leukemia virus type P (c-mpl-P)
      mRNA, complete cds
      gi|184260|gb|M90102.1|HSHMPLP[184260]
    • 15796: M98512
      Human NFG genomic fragment
      gi|292359|gb|M98512.1|HUMNF1FRAG[292359]
    • 15797: M98511
      Human NFE genomic fragment
      gi|292358|gb|M98511.1|HUMNF1FRAE[292358]
    • 15798: M98510
      Human NFC genomic fragment
      gi|292357|gb|M98510.1|HUMNF1FRAC[292357]
    • 15799: M98508
      Human NFA genomic fragment
      gi|292355|gb|M98508.1|HUMNF1FRAA[292355]
    • 15801: L32662
      Human prostaglandin E2 receptor EP3 subtype isoform IV mRNA, complete cds
      gi|484163|gb|L32662.1|HUMEP3IV[484163]
    • 15802: L32661
      Human prostaglandin E2 receptor EP3 subtype isoform III mRNA, 3′ end
      gi|48416|gb|L32661.1|HUMEP3III[484161]
    • 15803: L32660
      Human prostaglandin E2 receptor EP3 subtype isoform II mRNA, partial cds
      gi|484159|gb|L32660.1|HUMEP3II[484159]
    • 15822: L07594
      Human transforming growth factor-beta type III receptor (TGF-beta) mRNA, complete cds
      gi|818001|gb|L07594.1|HUMTGFB3C[818001]
    • 15823: M83181
      Human serotonin receptor gene, complete cds
      gi|8080000gb|M83181.1|HUMHTRB[808000]
    • 15824: M33602
      Human T-cell leukemia t(10:14) (q24:q11) chromosomal translocation
      gi|339907|gb|M33602.1|HUMTRANSX[339907]
    • 15828: L37112
      Homo sapiens vasopressin V3 receptor mRNA, complete cds
      gi|791151|gb|L37112.1|HUMVVR[791151]
    • 15829: L35901
      Human nicotinic acetylcholine receptor alpha 4 subunit (nAChR) mRNA, complete cds
      gi|755647|gb|L35901.1|HUMNACHR4A[755647]
    • 15830: U13666
      Human G protein-coupled receptor (GPR1) gene, complete cds
      gi|577412|gb|U13666.1|HSU13666[577412]
    • 15831: L35903
      Human dopamine D3 receptor gene, exon 6
      gi|532478|gb|L35903.1|UMDOPD30S2[532478]
    • 15832: L35902
      Human dopamine D3 receptor gene, exon 5
      gi|532477|gb|L35902.1|UMDOPD30S1[532477]
    • 15833: L37362
      Homo sapiens (clone d2-115) kappa opioid receptor (OPRK1) mRNA, complete cds
      gi|722617|gb|L37362.1|HUMOPRK1B[722617]
    • 15834: L35545
      Homo sapiens endothelial cell protein C/APC receptor (EPCR) mRNA, complete cds
      gi|565267|gb|L35545.1|HUMECPC[565267]
    • 15835: L36130
      Homo sapiens kappa opiate receptor mRNA, partial cds
      gi|598184|gb|L36130.1|HUMKOR[598184]
    • 15836: L36150
      Homo sapiens G protein-coupled receptor (GPR6) gene, complete cds
      gi|598156|gb|L361500.1HUMGPR6A[598156]
    • 15837: L36148
      Homo sapiens G protein-coupled receptor (GPR4) gene, complete cds
      gi|598152|gb|L36148.1|HUMGPR4A[598152]
    • 15839: L36149
      Homo sapiens G protein-coupled receptor (GPR5) gene, complete cds
      gi|598154|gb|L36149.1|HUMGPR5A[598154]
    • 15840: M64749
      Human homologue of the canine orphan receptor (RDC1) mRNA, 5′ end
      gi|292418|gb|M64749.1|HUMRDC1A[292418]
    • 15841: L35848
      Homo sapiens IgE receptor beta chain (HTm4) mRNA, complete cds
      gi|561638|gb|L35848.1|HUMIERB[561638]
    • 16011: L22431
      Human very low density lipoprotein receptor, complete cds
      gi|437386|gb|L22431.1|HUMVLDLRX[437386]
    • 16012: M90366
      Human zona pellucida glycoprotein 2 (ZP2) mRNA, complete cds
      gi|292939|gb|M90366.1|HUMZP2GP[292939]
    • 16015: M76125
      Human tyrosine kinase receptor (axl) mRNA, complete cds
      gi|292869|gb|M76125.1|HUMTYRKINR[292869]
    • 16016: L04489
      Homo sapiens (clone NCD18) tumor necrosis factor receptor related protein mRNA,
      complete exon and repeat region
      gi|340022|gb|L04489.1|HUMTUMNEC[340022]
    • 16017: M31163
      Human tumor necrosis factor-inducible (TSG-12) mRNA fragment
      gi|339990|gb|M31163.1|HUMTSG12A[339990]
    • 16019: M75866
      Human tumor necrosis factor receptor 1 (TNFR1) gene, complete cds
      gi|339748|gb|M75866.1|HUMTNFR103[339748]
    • 16020: M75865
      Human tumor necrosis factor receptor 1 (TNFR1) gene, exons 2-5
      gi|339747|gb|M75865.1|HUMTNFR102[339747]
    • 16021: M75864
      Human tumor necrosis factor receptor 1 (TNFR1) gene, exon 1
      gi|339746|gb|M75864.1|HUMTNFR101[339746]
    • 16026: M85079
      Human TGF-beta type II receptor mRNA, complete cds
      gi|339569|gb|M85079.1|HUMTGFBIIR[339569]
    • 16027: L06139
      Homo sapiens receptor protein-tyrosine kinase (TEK) mRNA, complete cds
      gi|292823|gb|L06139.1|HUMTEKRPTK[292823]
    • 16204: L29349
      Homo sapiens granulocyte-macrophage colony-stimulating factor receptor alpha-subunit 3 (GM-CSF-RA3) mRNA, complete cds
      gi|460284|gb|L29349.1|HUMGMCSA[460284]
    • 16205: L29348
      Homo sapiens granulocyte-macrophage colony-stimulating factor receptor alpha-subunit soluble isoform 2 (GM-CSF-RAS2) mRNA, complete cds
      gi|460282|gb|L29348.1|HUMGMCS[460282]
    • 16270: M74290
      Human substance P receptor protein mRNA
      gi|338612|gb|M74290.1|HUMSUBPRA[338612]
    • 16271: M96738
      Human somatostatin receptor subtype 3 (SSTR3) gene, complete cds
      gi|338498|gb|M96738.1|HUMSSTR3X[338498]
    • 16272: L13033
      Homo sapiens somatostatin receptor isoform 2 gene, alternatively spliced exon
      gi|292515|gb|L13033.1|HUMSSTR23X[292515]
    • 16273: L07833
      Homo sapiens somatostatin receptor (SSTR4) gene, complete cds
      gi|307429|gb|L07833.1|HUMSOMATA[307429]
    • 16274: L10126
      Human serine/threonine kinase receptor-2-3 (SKR2-3) mRNA, complete cds
      gi|558102|gb|L10126.1|HUMSKR23A[558102]
    • 16275: L10125
      Human serine/threonine kinase receptor-2-2 (SKR2-2) mRNA, complete cds
      gi|558101|gb|L10125.1|HUMSKR22A[558101]
    • 16276: J04132
      Human T cell receptor zeta-chain mRNA, complete cds
      gi|623041|gb|J04132.1|HUMTCRZCN[623041]
    • 16277: M93221
      Human macrophage mannose receptor (MRC1) gene, exon 30
      gi|187332|gb|M93221.1|HUMMANR30[187332]
    • 16278: M93220
      Human macrophage mannose receptor (MRC1) gene, exon 29
      gi|187331|gb|M93220.1|HUMMANR29[187331]
    • 16279: M93219
      Human macrophage mannose receptor (MRC1) gene, exon 28
      gi|187330|gb|M93219.1|HUMMANR28[187330]
    • 16280: M93218
      Human macrophage mannose receptor (MRC1) gene, exon 27
      gi|187329|gb|M93218.1|HUMMANR27[187329]
    • 16281: M93217
      Human macrophage mannose receptor (MRC1) gene, exon 26
      gi|187328|gb|M93217.1|HUMMANR26[187328]
    • 16282: M93216
      Human macrophage mannose receptor (MRC1) gene, exon 25
      gi|187327|gb|M93216.1|HUMMANR25[187327]
    • 16283: M93215
      Human macrophage mannose receptor (MRC1) gene, exon 24
      gi|187326|gb|M93215.1|HUMMANR24[187326]
    • 16284: M93214
      Human macrophage mannose receptor (MRC1) gene, exon 23
      gi|187325|gb|M93214.1|HUMMANR23[187325]
    • 16285: M93213
      Human macrophage mannose receptor (MRC1) gene, exon 22
      gi|187324|gb|M93213.1|HUMMANR22[187324]
    • 16286: M93212
      Human macrophage mannose receptor (MRC1) gene, exon 21
      gi|187323|gb|M93212.1|HUMMANR21[187323]
    • 16287: M93211
      Human macrophage mannose receptor (MRC1) gene, exon 20
      gi|187322|gb|M93211.1|HUMMANR20[187322]
    • 16288: M93210
      Human macrophage mannose receptor (MRC1) gene, exon 19
      gi|187321|gb|M93210.1|HUMMANR19[187321]
    • 16289: M93209
      Human macrophage mannose receptor (MRC1) gene, exon 18
      gi|187320|gb|M93209.1|HUMMANR18[187320]
    • 16290: M93208
      Human macrophage mannose receptor (MRC1) gene, exon 17
      gi|187319|gb|M93208.1|HUMMANR17[187319]
    • 16291: M93207
      Human macrophage mannose receptor (MRC1) gene, exon 16
      gi|187318|gb|M93207.1|HUMMANR16[187318]
    • 16292: M93206
      Human macrophage mannose receptor (MRC1) gene, exon 15
      gi|187317|gb|M93206.1|HUMMANR15[187317]
    • 16293: M93205
      Human macrophage mannose receptor (MRC1) gene, exon 14
      gi|187316|gb|M93205.1|HUMMANR14[187316]
    • 16294: M93204
      Human macrophage mannose receptor (MRC1) gene, exon 13
      gi|187315|gb|M93204.1|HUMMANR13[187315]
    • 16295: M93203
      Human macrophage mannose receptor (MRC1) gene, exon 12
      gi|187314|gb|M93203.1|HUMMANR12[187314]
    • 16296: M93202
      Human macrophage mannose receptor (MRC1) gene, exon 11
      gi|187313|gb|M93202.1|HUMMANR11[187313]
    • 16297: M93201
      Human macrophage mannose receptor (MRC1) gene, exon 10
      gi|187312|gb|M93201.1|HUMMANR10[187312]
    • 16298: M93200
      Human macrophage mannose receptor (MRC1) gene, exon 9
      gi|187311|gb|M93200.1|HUMMANR09[187311]
    • 16299: M93199
      Human macrophage mannose receptor (MRC1) gene, exon 8
      gi|187310|gb|M93199.1|HUMMANR08[187310]
    • 16300: M93198
      Human macrophage mannose receptor (MRC1) gene, exon 7
      gi|187309|gb|M93198.1|HUMMANR07[187309]
    • 16301: M93197
      Human macrophage mannose receptor (MRC1) gene, exon 6
      gi|187308|gb|M93197.1|HUMMANR06[187308]
    • 16302: M93196
      Human macrophage mannose receptor (MRC1) gene, exon 5
      gi|187307|gb|M93196.1|HUMMANR05[187307]
    • 16303: M93195
      Human macrophage mannose receptor (MRC1) gene, exon 4
      gi|187306|gb|M93195.1|HUMMANR04[187306]
    • 16304: M93194
      Human macrophage mannose receptor (MRC1) gene, exon 3
      gi|187305|gb|M93194.1HUMMANR03[187305]
    • 16305: M93193
      Human macrophage mannose receptor (MRC1) gene, exon 2
      gi|187304|gb|M93193.1HUMMANR02[187304]
    • 16306: M93192
      Human macrophage mannose receptor (MRC1) gene, exon 1
      gi|87303|gb|M93192.1|HUMMANR01[187303]
    • 16307: L05198
      Homo sapiens insulin receptor substrate 1 (IRS1) gene, repeat polymorphism
      gi|307396|gb|L05198.1|HUMIRS1RPT[307396]
    • 16308: M15365
      Human low density lipoprotein receptor mutant gene recombination site
      gi|187107|gb|M15365.1|HUMLDLRM[187107]
    • 16309: M80637
      Human keratinocyte growth factor receptor gene, exon K
      gi|186758|gb|M80637.1|HUMKKGFRA[186758]
    • 16310: M81778
      Human serotonin 5-HT1C receptor mRNA, complete cds
      gi|338027|gb|M81778.1|HUMSER5R[338027]
    • 16311: M81590
      Homo sapiens serotonin 1D receptor (5-HT1D-) mRNA, complete cds
      gi|338025|gb|M81590.1|HUMSER1DRB[338025]
    • 16312: M81589
      Homo sapiens serotonin 1D receptor (5-HT1D) mRNA, complete cds
      gi|338023|gb|M81589.1|HUMSER1DRA[338023]
    • 16313: M91455
      Human ryanodine receptor (RYR1) gene, exons 17 and 18
      gi|337723|gb|M91455.1|HUMRYR1[337723]
    • 16316: M97639
      Human transmembrane receptor (ror2) mRNA, complete cds
      gi|337466|gb|M97639.1|HUMROR2A[337466]
    • 16317: M97675
      Human transmembrane receptor (ror1) mRNA, complete cds
      gi|337464|gb|M97675.1|HUMROR1A[337464]
    • 16318: M74721
      Human B-cell antigen receptor (MB-1) mRNA, complete cds
      gi|337419|gb|M74721.1|HUMRIGMAMB[337419]
    • 16319: M89796
      Human high affinity IgE receptor beta chain gene, complete cds
      gi|337417|gb|M89796.1|HUMRIGBCHA[337417]
    • 16329: L09247
      Human receptor-type protein tyrosine phosphatase gamma (PTPRG) mRNA, complete cds
      gi|292410|gb|L09247.1|HUMPTPRG[292410]
    • 16330: M93426
      Human protein tyrosine phosphatase zeta-polypeptide (PTPRZ) mRNA, complete cds
      gi|190743|gb|M93426.1|HUMPTPRZ[190743]
    • 16331: M88177
      Human platelet activating factor receptor (PTAFR) gene, complete cds
      gi|190697|gb|M88177.1|HUMPTAFR[190697]
    • 16332: L16862
      Homo sapiens G protein-coupled receptor kinase (GRK6) mRNA, complete cds
      gi|388766|gb|L16862.1|HUMPROCRKI[388766]
    • 16333: M86528
      Human neurotrophin-4 (NT-4) gene, complete cds
      gi|190264|gb|M86528.1|HUMPPNT4P[190264]
    • 16334: L07334
      Human platelet-activating factor receptor mRNA, complete cds
      gi|1190014gb|L07334.1|HUMPLACTFR[190014]
    • 16335: L26976
      Human prostalandin receptor (PGE-2) mRNA, complete cds
      gi|473428|gb|L26976.1|HUMPGE2REP[473428]
    • 16336: M88107
      Human formyl peptide receptor (FPR2) mRNA, complete cds
      gi|189862|gb|M88107.1|HUMPFPR2A[189862]
    • 16337: M76674
      Human platelet activating factor receptor (PAFR) mRNA, complete cds
      gi|456293|gb|M76674.1|HUMPAFRX[456293]
    • 16338: M80436
      Human platelet activating factor receptor mRNA, complete cds
      gi|189537|gb|M80436.1|HUMPAFR[189537]
    • 16339: L26079
      Homo sapiens (clone hSR4-1) kappa opioid receptor (OPRK1) gene, complete exon
      gi|416143|gb|L26079.1|HUMOPRK1A[416143]
    • 16340: L07615
      Human neuropeptide Y receptor Y1 (NPYY1) mRNA, exon 2-3 and complete cds
      gi|189284|gb|L07615.1|HUMNPYY1A2[189284]
    • 16341: L07614
      Human neuropeptide Y receptor Y1 (NPYY1) mA, exon 1
      gi|189283|gb|L07614.1|PYY1A1[189283]
    • 16342: M37981
      Human alpha-3 neuronal nicotinic acetylcholine receptor subunit mRNA, complete
      cds
      gi|189252|gb|M37981.1|HUMNNAR[189252]
    • 16343: M73482
      Human neuromedin B receptor (NMB-R) mRNA, complete cds
      gi|18924|gb|M73482.1|HUMNMBR[189241]
    • 16344: M76675
      Human neurokinin 1 receptor (NKIR) mRNA, complete cds
      gi|189231|gb|M76675.1|HUMNKIRX[189231]
    • 16345: M81797
      Human NK-1 receptor mRNA, complete cds
      gi|189213|gb|M81797.1|HUMNK1A[189213]
    • 16346: M32315
      Human tumor necrosis factor receptor mRNA, complete cds
      • Human tumor necrosis factor receptor mRNA, complete cds
        gi|189185|gb|M32315.1|HUMNFR[189185]
    • 16347: M84755
      Human neuropeptide y receptor mRNA, complete cds
      gi|189153|gb|M84755.1|HUMNEUYREC[189153]
    • 16348: M83246
      Human monocyte activation antigen (Mo3) mRNA, complete cds
      gi|188623|gb|M83246.1|HUMMO3A[188623]
    • 16350: L27080
      Human melanocortin 5 receptor (MC5R) gene, complete cds
      gi|435599|gb|L27080.1|HUMMC5R[435599]
    • 16351: M28219
      Homo sapiens low density lipoprotein receptor (FH 10 mutant causing familial hypercholesterolemia) mRNA, 3′ end
      gi|619785|gb|M28219.1|HUMLDLRFMT[619785]
    • 16352: M12626
      Human low density lipoprotein receptor gene, FH381 (deletion mutant) allele
      gi|187103|gb|M12626.1|HUMLDLRFH[187103]
    • 16353: M93189
      Human acetylated low density lipoprotein (ACLDL) receptor (LDLR) gene, promoter
      and exon 1
      gi|187100|gb|M93189.1|HUMLDLRAC[187100]
    • 16354: M87772
      Human secreted fibroblast growth factor receptor (K-sam-IV) mRNA, complete cds
      gi|186783|gb|M87772.1|HUMKSAMIV[186783]
    • 16355: M87771
      Human secreted fibroblast growth factor receptor (K-sam-III) mRNA, complete cds
    • 16356: M87770
      Human fibroblast growth factor receptor (K-sam) mRNA, complete cds
      gi|186779|gb|M87770.1|HUMKSAMI[186779]
    • 16357: L04947
      Homo sapiens (clones BT3.081.8, BT3.129.5 and BT4.169) receptor tyrosine kinase
      (KDR) mRNA, 31 end cds
      gi|186674|gb|L04947.1|HUMKDRZ[186674]
    • 16358: M32972
      Human insulin receptor (INSR) gene, exon 22, clones lambda-hINSR-(1-13)
      gi|186462|gb|M32972.1|HUMINSR22[186462]
    • 16359: M32842
      Human insulin receptor (INSR) gene, exon 21, clones lambda-hINSR-(1-13)
      gi|8646|gb|M32842.1|HUMINSR21[186461]
    • 16360: M32841
      Human insulin receptor (INSR) gene, exon 20, clones lambda-hINSR-(1-13)
      gi|186460|gb|M32841.1|HUMINSR20[186460]
    • 16361: M32840
      Human insulin receptor (INSR) gene, exon 19, clones lambda-hINSR-(1-13)
      gi|186459|gb|M32840.1|HUMINSR19[186459]
    • 16362: M32839
      Human insulin receptor (INSR) gene, exon 18, clones lambda-hINSR-(1-13)
      gi|186458|gb|M32839.1|HUMINSR18[186458]
    • 16363: M32838
      Human insulin receptor (hINSR) gene, exon 17, clones lambda-hINSR-(1-13)
      gi|186457|gb|M32838.1|HUMINSR17[186457]
    • 16364: M32837
      Human insulin receptor (INSR) gene, exon 16, clones lambda-hINSR-(1-13)
      gi|186456|gb|M32837.1|HUMINSR16[186456]
    • 16365: M32836
      Human insulin receptor (INSR) gene, exon 15, clones lambda-hINSR-(1-13)
      gi|186455|gb|M32836.1|HUMINSR15[186455]
    • 16366: M32835
      Human insulin receptor (INSR) gene, exon 14, clones lambda-hINSR-(1-13)
      gi|186454|gb|M32835.1|HUMINSR14[186454]
    • 16367: M32834
      Human insulin receptor (INSR) gene, exon 13, clones lambda-hINSR-(1-13)
      gi|186453|gb|M32834.1|HUMINSR13[186453]
    • 16368: M32833
      Human insulin receptor (INSR) gene, exon 12, clones lambda-hINSR-(1-13)
      gi|186452|gb|M32833.1|HUMINSR12[186452]
    • 16369: M32832
      Human insulin receptor (INSR) gene, exon 11, clones lambda-hINSR-(1-13)
      gi|186451|gb|M32832.1|HUMINSR11[186451]
    • 16370: M32831
      Human insulin receptor (INSR) gene, exon 10, clones lambda-hINSR-(1-13)
      gi|186450|gb|M32831.1|HUMINSR10[186450]
    • 16371: M32830
      Human insulin receptor (hINSR) gene, exon 9, clones lambda-hINSR-(1-13)
      gi|186449|gb|M32830.1|HUMINSR09[186449]
    • 16372: M32829
      Human insulin receptor (INSR) gene, exon 8, clones lambda-hINSR-(1-13)
      gi|186448|gb|M32829.1|HUMINSR08[186448]
    • 16373: M32828
      Human insulin receptor (INSR) gene, exon 7, clones lambda-hINSR-(1-13)
      gi|186447|gb|M32828.1|HUMINSR07[186447]
    • 16374: M32827
      Human insulin receptor (INSR) gene, exon 6, clones lambda-hINSR-(1-13)
      gi|186446|gb|M32827.1|HUMINSR06[186446]
    • 16375: M32826
      Human insulin receptor (INSR) gene, exon 5, clones lambda-hINSR-(1-13)
      gi|186445|gb|M32826.1|HUMINSR05[186445]
    • 16376: M32825
      Human insulin receptor (INSR) gene, exon 4, clones lambda-hINSR-(1-13)
      gi|186444|gb|M32825.1|HUMINSR04[186444]
    • 16377: M32824
      Human insulin receptor (INSR) gene, exon 3, clones lambda-hINSR-(1-13)
      gi|186443|gb|M32824.1|HUMINSR03[186443]
    • 16378: M32823
      Human insulin receptor (INSR) gene, exon 2, clones lambda-hINSR-(1-13)
      gi|186442|gb|M32823.1|HUMINSR02[186442]
    • 16379: M23100
      Human insulin receptor (INSR) gene, exon 1, clones lambda-hINSR-(1-13)
      gi|186441|gb|M23100.1|HUMINSR01[186441]
    • 16380: J05043
      Human insulin receptor (1R) gene, exon 1
      gi|186556|gb|J05043.1|HUMIRSRE[186556]
    • 16381: M24555
      Human insulin receptor (INSR) mRNA, partial cds
      gi|186480|gb|M24555.1|HUMINSRZ[186480]
    • 16382: L07782
      Human insulin receptor gene, last exon
      gi|186475|gb|L07782.1|HUMINSRE[186475]
    • 16383: J03466
      Human insulin receptor gene, exon 1, clone p-lambda EA2
      gi|186469|gb|J03466.1|HUMINSRB[186469]
    • 16384: L19592
      Homo sapiens interleukin 8 receptor alpha (IL8RA) gene, complete cds
      gi|559051|gb|L19592.1|HUMIL8RAB[559051]
    • 16385: M15864
      Human interleukin-2 receptor alpha (IL2R-alpha) gene, exon 1 and promoter region
      gi|186375|gb|M15864.1|HUMILA2R1A[186375]
    • 16387: M68932
      Human IL-8 receptor mRNA, complete cds
      gi|186369|gb|M68932.1|HUMIL8RA[186369]
    • 16388: L12183
      Human interleukin 2 receptor gamma chain (IL2RG) gene, exon 8 and complete cds
      gi|307056|gb|L12183.1|HUMIL2RG08[307056]
    • 16389: L12182
      Human interleukin 2 receptor gamma chain (IL2RG) gene, exon 7
      gi|307055|gb|L12182.1|HUMIL2RG07[3070155]
    • 16390: L12181
      Human interleukin 2 receptor gamma chain (IL2RG) gene, exon 6
      gi|307054|gb|L12181.1|HUMIL2RG06[307054]
    • 16391: L12180
      Human interleukin 2 receptor gamma chain (IL2RG) gene, exon 5
      gi|307053|gb|L12180.1|HUMIL2RG05[307053]
    • 16392: L12179
      Human interleukin 2 receptor gamma chain (IL2RG) gene, exon 4
      gi|307052|gb|L12179.1|HUMIL2RG04[307052]
    • 16393: L12177
      Human interleukin 2 receptor gamma chain (IL2RG) gene, exon 3
      gi|307051|gb|L12177.1|HUMIL2RG03[307051]
    • 16394: L12176
      Human interleukin 2 receptor gamma chain (IL2RG) gene, exon 2
      gi|307050|gb|L12176.1|HUMIL2RG02[307050]
    • 16395: L12178
      Human interleukin 2 receptor gamma chain (IL2RG) gene, exon 1 and promoter region
      gi|307049|gb|L12178.1|HUMIL2RG01[307049]
    • 16396: M96652
      Human interleukin 5 receptor alpha-subunit (IL5R) mRNA, complete cds
      gi|186344|gb|M96652.1|HUMILSRB[186344]
    • 16397: M96651
      Human interleukin 5 receptor alpha-subunit (IL5R) mRNA, complete cds
      gi|186342|gb|M96651.1|HUMIL5RA[186342]
    • 16398: M74782
      Human interleukin 3 receptor (hIL-3Ra) mRNA, complete cds
      gi|186330|gb|M74782.1|HUMIL3B[186330]
    • 16405: M84967
      Human acrosin-trypsin inhibitor (HUSI-II) gene
      gi|553347|gb|M84967.1|HUMHUSIIIA[553347]
    • 16406: M84747
      Human interleukin 9 receptor mRNA, complete cds
      gi|184508|gb|M84747.1|HUMI9R[184508]
    • 16407: M75128
      Human serotonin 1Db receptor (HTR1D) gene, complete cds
      gi|184459|gb|M75128.1|HUMHTR1DB[184459]
    • 16408: M64799
      Human histamine H2 receptor gene, complete cds
      gi|184087|gb|M64799.1|HUMHISH2R[184087]
    • 16409: M83941
      Human receptor tyrosine kinase (HEK) mRNA, complete cds
      gi|183931|gb|M83941.1|HUMHEK[183931]
    • 16410: L20814
      Human glutamate receptor 2 (HBGR2) mRNA, complete cds
      gi|493133|gb|L20814.1|HUMHBGR2A[493133]
    • 16412: L09237
      growth hormone releasing hormone receptor, human, G-protein coupled receptor, secretin family
      gi|337134|gb|L09237.1|HUMGRFREC1[337134]
    • 16413: L15388
      Human G protein-coupled receptor kinase (GRK5) mRNA, complete cds
      gi|306804|gb|L15388.1|HUMGRK5A[306804]
    • 16415: L08176
      Human Epstein-Barr virus induced G-protein coupled receptor mRNA, complete cds
      gi|183484|gb|L08176.1|HUMGPCRA[183484]
    • 16416: M64752
      Human glutamate receptor subunit (GluH1) mRNA, complete cds
      gi|183280|gb|M64752.1|HUMGLURS[183280]
    • 16417: L34075
      Human FKBP-rapamycin associated protein (FRAP) mRNA, complete cds
      gi|508481|gb|L34075.1|HUMFRAPX[508481]
    • 16418: L08485
      Human GABA-benzodiazepine receptor alpha-5-subunit (GABRA5) mRNA, complete cds
      gi|182915|gb|L08485.1|HUMGABRA5Y[182915]
    • 16419: M93435
      Human gamma-aminobutyric acid receptor A5 subunit (GABRA5) gene
      gi|182914|gb|M93435.1|HUMGABRASX[182914]
    • 16421: M76673
      Human RMLP-related receptor I (RMLP R I) mRNA, complete cds
      gi|182668|gb|M76673.1|HUMFMLPY[182668]
    • 16422: M76672
      Human FMLP-related receptor II (FMLP R II) mRNA, complete cds
      gi|182666|gb|M76672.1|HUMFMLPX[182666]
    • 16423: M64347
      Human novel growth factor receptor mRNA, 3′ cds
      gi|182564|gb|M64347.1|HUMFGFLR[182564]
    • 16424: M74921
      Human endothelin receptor mRNA, complete cds
      gi|182275|gb|M74921.1|HUMETSR[182275]
    • 16427: M96995
      Homo sapiens epidermal growth factor receptor-binding protein GRB2 (EGFRBP-GRB2) mRNA sequence
      gi|181975|gb|M96995.1|HUMEGFGRBA[181975]
    • 16428: L06622
      Homo sapiens endothelin receptor type A (EDNRA) mRNA, complete cds
      gi|181956|gb|L06622.1|HUMEDNRA[181956]
    • 16434: M26317
      Homo sapiens (clone lambda-6.11) complement receptor 2 (CR2) allele, mRNA fragment
      gi|541647|gb|M26317.1|HUMCR2ALLE[541647]
    • 16435: M25785
      Homo sapiens transmembrane glycoprotein (c-fms) gene, exon 1, and platelet-derived growth factor receptor (PDGF) gene, 3′UTR
      gi|349453|gb|M25785.1|HUMCFMS01[349453]
    • 16436: M91555
      Human Fc gamma receptor type I (CD64) gene, exon 6
      gi|180160|gb|M91555.1|HUMCD6406[180160]
    • 16437: M91554
      Human Fc gamma receptor type I (CD64) gene, exon 5
      gi|180159|gb|M91554.1|HUMCD6405[180159]
    • 16438: M91553
      Human Fc gamma receptor type I (CD64) gene, exon 4
      gi|180158|gb|M91553.1|HUMCD6404[180158]
    • 16439: M91552
      Human Fc gamma receptor type I (CD64) gene, exon 3
      gi|180157|gb|M91552.1|HUMCD6403[180157]
    • 16440: M91551
      Human Fc gamma receptor type I (CD64) gene, exon 2
      gi|180156|gb|M91551.1|HUMCD6402[180156]
    • 16441: M91550
      Human Fc gamma receptor type I (CD64) gene, exon 1
      gi|180155|gb|M91550.1|HUMCD6401[180155]
    • 16442: M63928
      Homo sapiens T cell activation antigen (CD27) mRNA, complete cds
      gi|180084|gb|M63928.1|HUMCD27A[180084]
    • 16443: M95293
      Homo sapiens integrin beta subunit (CD18) gene, exon 1
      gi|180022|gb|M95293.1|HUMCD18EX[180022]
    • 16444: M76724
      Human leukocyte adhesion receptor alpha subunit (CD11b) gene, 5′ end
      gi|180018|gb|M76724.1|HUMCD11B[180018]
    • 16447: L09230
      Human C-C chemokine receptor type 1 (C-C CKR-1) mRNA, complete cds
      gi|179984|gb|L09230.1|HUMCCCKR1A[179984]
    • 16448: M81886
      Human glutamate receptor type 1 (HBGR1) mRNA, complete cds
      gi|17944|gb|M81886.1|HUMBGR1A[179441]
    • 16449: M80776
      Human beta-adrenergic receptor kinase 1 mRNA, complete cds
      gi|179334|gb|M80776.1|HUMBARK1A[179334]
    • 16450: L25259
      Human CTLA4 counter-receptor (B7-2) mRNA, complete cds
      gi|416368|gb|L25259.1|HUMB72A[416368]
    • 16451: M93394
      Human angiotensin 11 type-1 receptor (AT1) mRNA, complete cds
      gi|178680|gb|M93394.1|HUMANTIIR[178680]
    • 16452: M83712
      H. sapiens nicotinic receptor alpha 5 subunit mRNA, complete cds
      gi|177925|gb|M83712.1|HUMA5NICRC[177925]
    • 16453: M97370
      Human adenosine receptor (A2) gene, complete cds
      gi|177891|gb|M97370.1|HUMA2XXX[177891]
    • 16454: M92826
      Human serotonin receptor (5-HTR1E) gene, complete cds
      gi|177777|gb|M92826.1|HUM5HTR1E[177777]
    • 16455: M86841
      Human serotonin receptor type 2 (5HT2) mRNA, complete cds
      gi|177775|gb|M86841.1|HUM5HT2A[177775]
    • 16456: M91467
      Human serotonin receptor (5HT1E) mRNA, complete cds
      gi|177773|gb|M91467.1|HUM5HT1E[177773]
    • 16457: M81830
      Human somatostatin receptor isoform 2 (SSTR2) gene, complete cds
      gi|307435|gb|M81830.1|HUMSRI2A[307435]
    • 16458: M81829
      Human somatostatin receptor isoform 1 gene, complete cds
      gi|307433|gb|M81829.1|HUMSRI1A[307433]
    • 16463: L20470
      Human very low density lipoprotein receptor mRNA, complete cds
      gi|409425|gb|L20470.1|HUMVLDLR[409425]
    • 16464: L20316
      Human glucagon receptor mRNA, complete cds
      gi|405189|gb|L20316.1|HUMGLUCREC[405189]
    • 16465: M24853
      Homo sapiens (clone H12) low affinity IgG receptor CD16 (FcGRIII) mRNA, 3′ end
      gi|184849|gb|M24853.1|HUMIGGRLA[184849]
    • 16466: M80635
      Human fibroblast growth factor receptor-2 (FGFR2) gene, exon B
      gi|182572|gb|M80635.1|HUMFGFRA[182572]
    • 16467: L31848
      Homo sapiens serine/threonine kinase receptor 2 (SKR2) gene, 3 alternative splices, 3′ ends
      gi|576680|gb|L31848.1|HUMSKR2[576680]
    • 16472: M29066
      Human dopamine D2 receptor (DRD2) mRNA, complete cds
      gi|181828|gb|M29066.1|HUMDRD2A[181828]
    • 16473: M85289
      Human heparan sulfate proteoglycan (HSPG2) mRNA, complete cds
      gi|184426|gb|M85289.1|HUMHSPG2B[184426]
    • 16474: L02931
      Human hepatocyte growth factor heavy chain (HGF) gene mRNA, complete cds
      gi|184033|gb|L02931.1|HUMHGFX[184033]
    • 16475: L19058
      Human glutamate receptor (GLUR5) mRNA, complete cds
      gi|455447|gb|L19058.1|HUMGLUR5X[455447]
    • 16476: L20859
      Human leukemia virus receptor 1 (GLVR1) mRNA, complete cds
      gi|306769|gb|L20859.1|HUMGLVR1X[306769]
    • 16477: M82919
      Human gamma amino butyric acid (GABAA) receptor beta-3 subunit mRNA, complete cds
      gi|182924|gb|M82919.1|HUMGABRB3A[182924]
    • 16478: M86868
      Human gamma amino butyric acid (GABA rho2) gene mRNA, complete cds
      gi|182912|gb|M86868.1|HUMGABARHO[182912]
    • 16479: L14061
      Human N-formyl receptor-like 2 protein (FPRL2) gene, complete cds
      gi|292034|gb|L14061.1|HUMFRPL2[292034]
    • 16480: M95489
      H. sapiens follicle stimulating hormone receptor mRNA, complete cds
      gi|182772|gb|M95489.1|HUMFSHREC[182772]
    • 16481: M84562
      Human formyl peptide receptor-like receptor (FPRL1) mRNA, complete cds
      gi|182741|gb|M84562.1|HUMFPRL1A[182741]
    • 16482: M97193
      Homo sapiens fibroblast growth factor receptor 2 IIIb (FGFR2) mRNA, complete cds
      gi|182566|gb|M97193.1|HUMFGFR2A[182566]
    • 16483: M23562
      Human IgE Fc-epsilon-RIIa gene, exon 2, and Fc-epsilon-RIIb gene, exon 1
      gi|182444|gb|M23562.1|HUMFCEIIA[182444]
    • 16484: M76595
      Human erythropoietin receptor mRNA sequence derived from DNA, 5′ end
      gi|182147|gb|M76595.1|HUMEPR[182147]
    • 16485: M77244
      H. sapiens erythropoietin receptor (EPOR) gene, 5′ end
      gi|182133|gb|M77244.1|HUMEPOR[182133]
    • 16486: M24736
      Human endothelial leukocyte adhesion molecule 1 (ELAM-1) mRNA, complete cds
      gi|537523|gb|M24736.1|HUMELAM1A[537523]
    • 16487: L37361
      Homo sapiens (clone hELK-L) ELK receptor tyrosine kinase ligand (EFL-3) mRNA, complete cds
      gi|567005|gb|L37361.1|HUMEFL3[567005]
    • 16488: L37360
      Homo sapiens (clone hEHK1-L) EHK1 receptor tyrosine kinase ligand (EFL-2) mRNA,
      complete cds
      gi|567003|gb|L37360.1|HUMEFL2[567003]
    • 16489: K03193
      Human aberrant (short) epidermal growth factor receptor mRNA, complete cds
      gi|181984|gb|K03193.1|HUMEGFRS[181984]
    • 16490: M11234
      Human epidermal growth factor receptor (EGFR) gene, exon 1
      gi|181981|gb|M11234.1|HUMEGFRG[181981]
    • 16491: L06623
      Homo sapiens endothelin receptor type B (EDNRB) mRNA, complete cds
      gi|9181958|gb|L06623.1|HUMEDNRB[181958]
    • 16494: M67439
      Human D5 dopamine receptor (DRD5) gene, complete cds
      gi|181830|gb|M67439.1|HUMDRD5A[181830]
    • 16495: M77250
      Human dopamine D2 receptor gene, intron 6/exon 7 boundary
      gi|181825|gb|M77250.1|HUMDRD24[181825]
    • 16496: M77249
      Human dopamine D2 receptor gene; exon 3
      gi|181824|gb|M77249.1|HUMDRD23[181824]
    • 16497: M77247
      Human dopamine D2 receptor gene, exon 2
      gi|181823|gb|M77247.1|HUMDRD22[181823]
    • 16498: M77248
      Human dopamine D2 receptor gene, exon 1
      gi|181822|gb|M77248.1|HUMDRD21[181822]
    • 16499: M33210
      Human colony stimulating factor 1 receptor (CSF1R) gene, exon 5
      gi|532591|gb|M33210.1|HUMCSF1R03[532591]
    • 16500: M33209
      Human colony stimulating factor 1 receptor (CSF1R) gene, exon 4
      gi|532590|gb|M33209.1|HUMCSF1R02[532590]
    • 16501: M33208
      Human colony stimulating factor 1 receptor (CSF1R) gene, exon 2
      gi|532589|gb|M33208.1|HUMCSF1R01[532589]
    • 16502: M83328
      Human cell surface glycoprotein CD44 mRNA, (variant F) exons 1, 2, 3, and 5
      gi|180135|gb|M83328.1|HUMCD44J[180135]
    • 16503: M83327
      Human cell surface glycoprotein CD44 mRNA, (variant E) exons 1, 2, 3, and 4
      gi|180134|gb|M83327.1|HUMCD441[180134]
    • 16504: M83326
      Human cell surface glycoprotein CD44 mRNA, (variant D) exon 1, 2, and 3
      gi|180133|gb|M83326.1|HUMCD44H[180133]
    • 16505: M83325
      Human cell surface glycoprotein CD44 mRNA, (variant C) exons 1 and 2
      gi|180132|gb|M83325.1|HUMCD44G[180132]
    • 16506: M83324
      Human cell surface glycoprotein CD44 mRNA, (variant B) exon 1
      gi|180131|gb|M83324.1|HUMCD44F[180131]
    • 16507: M83554
      H. sapiens lymphocyte activation antigen CD30 mRNA, complete cds
      gi|180095|gb|M83554.1|HUMCD30A[180095]
    • 16512: M97759
      Human adenosine A2b receptor (ADORA2) mRNA, complete cds
      gi|178149|gb|M97759.1|HUMADORA1[178149]
    • 16513: M80333
      Human m5 muscarinic acetylcholine receptor gene, complete cds
      gi|177987|gb|M80333.1|HUMACHRM[177987]
    • 16527: L34339
      Human galanin receptor mRNA, complete cds
      gi|559047|gb|L34339.1|HUMGALAREC[559047]
    • 16528: L17033
      Human heparin-binding epidermal growth factor gene sequence
      gi|348176|gb|L17033.1|HUMHBEGFF[348176]
    • 16529: L17032
      Human heparin-binding epidermal growth factor gene sequence
      gi|348175|gb|L17032.1|HUMHBEGFE[348175]
    • 16530: L17031
      Human heparin-binding epidermal growth factor gene, 3′ end
      gi|348173|gb|L17031.1|HUMHBEGFD[348173]
    • 16531: L17030
      Human heparin-binding epidermal growth factor gene, partial cds
      gi|348171|gb|L17030.1|HUMHBEGFC[348171]
    • 16532: L17029
      Human heparin-binding epidermal growth factor gene, partial cds
      gi|348169|gb|L17029.1|HUMHBEGFB[348169]
    • 16533: L17028
      Human heparin-binding epidermal growth factor gene, 5′ end
      gi|348168|gb|L17028.1|HUMHBEGFA[348168]
    • 16534: L13288
      Human vasoactive intestial peptide receptor mRNA, complete cds
      gi|292903|gb|L13288.1|HUMVIPR[292903]
    • 16545: M31164
      Human tumor necrosis factor-inducible (TSG-37) mRNA fragment
      gi|339993|gb|M31164.1|HUMTSG37A[339993]
    • 16547: L04270
      Homo sapiens (clone CD18) tumor necrosis factor receptor 2 related protein mRNA,
      complete cds
      gi|339761|gb|L04270.1|HUMTNFRRP[339761]
    • 16548: M58286
      Homo sapiens tumor necrosis factor receptor mRNA, complete cds
      gi|339753|gb|M58286.1|HUMTNFRB[339753]
    • 16562: L07062
      Human somatostatin receptor 3 (SSTR3) gene
      gi|348713|gb|L07062.1|HUMSSTR3Y[348713]
    • 16563: L07061
      Human somatostatin receptor 4 (SSTR4) gene
      gi|348712|gb|L07061.1|HUMSSTR4Z[348712]
    • 16564: M73489
      Human heat-stable enterotoxin receptor mRNA, complete cds
      gi|338501|gb|M73489.1|HUMSTAR[338501]
    • 16565: L04962
      Homo sapiens serotonin receptor (HTR1F) gene, complete cds
      gi|338464|gb|L04962.1|HUMSRCPT1F[338464]
    • 16566: M84426
      Homo sapiens substance P receptor (short form) mRNA, complete cds
      gi|338435|gb|M84426.1|HUMSPRSHOR[338435]
    • 16567: M84425
      Homo sapiens substance P receptor (long form) mRNA, complete cds
      gi|338427|gb|M84425.1|HUMSPRLONG[338427]
    • 16568: M97190
      Human Sp2 protein mRNA, complete cds
      gi|338300|gb|M97190.1|HUMSP2A[338300]
    • 16569: L05521
      Human somatostatin receptor subtype 2 gene related dinucleotide repeat
      gi|292502|gb|L05521.1|HUMSOMREPB[292502]
    • 16570: L05520
      Human somatostatin receptor subtype 1 gene related dinucleotide repeat
      gi|292501|gb|L05520.1|HUMSOMREPA[292501]
    • 16570: L14856
      Human somatostatin receptor gene, complete cds
      gi|292499|gb|L14856.1|HUMSOMAT[292499]
    • 16572: L02911
      Human novel serine kinase receptor mRNA, complete cds
      gi|338218|gb|L02911.1|HUMSKRN[338218]
    • 16573: L05597
      Human serotonin receptor gene, complete cds
      gi|307419|gb|L05597.1|HUMSEROTON[307419]
    • 16576: L10918
      Homo sapiens macrophage inflammatory protein-1-alpha/RANTES receptor mRNA, complete cds
      gi|292416|gb|L10918.1|HUMRANTES[292416]
    • 16577: L28824
      Homo sapiens protein tyrosine kinase (Syk) mRNA, complete cds
      gi|479012|gb|L28824.1|HUMPTK[479012]
    • 16578: L04308
      Human parathyroid hormone receptor mRNA, complete cds
      gi|190721|gb|L04308.1|HUMPTHR[190721]
    • 16579: L02932
      Human peroxisome proliferator activated receptor mRNA, complete cds
      gi|307340|gb|L02932.1|HUMPPAR[307340]
    • 16580: L07592
      Human peroxisome proliferator activated receptor mRNA, complete cds
      gi|190229|gb|L07592.1|HUMPPARA[190229]
    • 16581: L29016
      Homo sapiens prostanoid IP receptor, complete cds
      gi|495042|gb|L29016.1|HUMPIR[495042]
    • 16582: L25124
      Homo sapiens prostaglandin E2 receptor mRNA, complete cds
      gi|435049|gb|L25124.1|HUMPGE2R[435049]
    • 16583: L28175
      Homo sapiens prostaglandin E2 receptor EP2 subtype mRNA, complete cds
      gi|452495|gb|L28175.1|HUMPERE[452495]
    • 16584: M84986
      Human DNA sequence from 5-hydroxytryptamine 1B receptor region
      gi|189401|gb|M84986.1|HUMORFZ[189401]
    • 16585: M84605
      Human putative opioid receptor mRNA, complete cds
      gi|189391|gb|M84605.1|HUMOPIODRE[189391]
    • 16587: M89473
      Human neurokinin 3 receptor (NK3R) mRNA, complete cds
      gi|189223|gb|M89473.1|HUMNK3R[189223]
    • 16588: L12214
      Human N-formyl receptor gene
      gi|189182|gb|L12214.1|HUMNFORECB[189182]
    • 16589: L12213
      Human N-formyl receptor gene
      gi|189181|gb|L12213.1|HUMNFORECA[189181]
    • 16590: L13267
      Homo sapiens N-methyl-d-aspartate receptor (NR1-2) mRNA, 3′ end
      gi|292284|gb|L13267.1|HUMMARA[292284]
    • 16591: M80634
      Human keratinocyte growth factor receptor mRNA, complete cds
      gi|186740|gb|M80634.1|HUMKGFRA[186740]
    • 16592: M80638
      Human keratinocyte growth factor receptor and fibroblast growth factor receptor-2 gene, exon
      gi|186737|gb|M80638.1|HUMKFGFRB[186737]
    • 16593: M80636
      Human keratinocyte growth factor receptor and fibroblast growth factor receptor-2 gene, exon
      gi|186736|gb|M80636.1|HUMKFGFRA[186736]
    • 16594: M59911
      Human integrin alpha-3 chain mRNA, complete cds
      gi|186496|gb|M59911.1|HUMINTA3A[186496]
    • 16595: M75914
      Human interleukin 5 receptor alpha mRNA, complete cds
      gi|186387|gb|M75914.1|HUMILSRAA[186387]
    • 16596: M73724
      Human insulin-like growth factor-I receptor gene, exon 1
      gi|186383|gb|M73724.1|HUMILGFIR[186383]
    • 16597: M94582
      Human interleukin 8 receptor B mRNA, complete cds
      gi|186377|gb|M94582.1|HUMILEU8R[186377]
    • 16599: M24559
      Human poly-Ig receptor transmembrane secretory component mRNA, 3′ end
      gi|514365|gb|M24559.1|HUMIGRPOLY[514365]
    • 16600: L03418
      Human Fc-gamma receptor I A1 mRNA, complete cds
      gi|184840|gb|L03418.1|HUMIGGFCIA[184840]
    • 16601: M73780
      Human integrin beta-8 subunit mRNA, complete cds
      gi|184520|gb|M73780.1|HUMIBBSUA[184520]
    • 16602: L09732
      Homo sapiens 5-hydroxytryptamine 1D receptor gene, complete cds
      gi|184467|gb|L09732.1|HUMHTRD1A[184467]
    • 16603: M83180
      Human serotonin receptor gene, complete cds
      gi|184463|gb|M83180.1|HUMHTRA[184463]
    • 16605: M63889
      Human heparin-binding growth factor receptor (HBGF-R-alpha-a3) mRNA, complete cds
      gi|183882|gb|M63889.1|HUMHBGFC[183882]
    • 16606: L22607
      Homo sapiens A3 adenosine receptor mRNA, complete cds
      gi|413863|gb|L22607.1|HUMHAAR[413863]
    • 16607: M82819
      Human DNA sequence
      gi|183778|gb|M82819.1|HUMHAIGGR[183778]
    • 16608: L13436
      Homo sapiens guanylate cyclase mRNA, complete mature peptide
      gi|292071|gb|L13436.1|HUMGUANCYC[292071]
    • 16609: L08177
      Human EBV induced G-protein coupled receptor (EBI2) mRNA, complete cds
      gi|292056|gb|L08177.1|HUMGPCRB[292056]
    • 16610: L07949
      Homo sapiens GnRH receptor mRNA, complete cds
      gi|292052|gb|L07949.1|HUMGNRHR[292052]
    • 16611: L03380
      Human gonadotropin-releasing hormone receptor mRNA, complete cds
      gi|18342|gb|L03380.1|HUMGNRHREC[183421]
    • 16612: M73832
      Human GM-CSF receptor (GM-CSF receptor) mRNA, complete cds
      gi|306773|gb|M73832.1|HUMGMCSFRA[306773]
    • 16613: M64445
      Human GM-CSF receptor mRNA, complete cds
      gi|183361|gb|M64445.1|HUMGMCSF[183361]
    • 16614: L24751
      Homo sapiens glucagon receptor gene, partial cds
      gi|404723|gb|L24751.1|HUMGLCGNR[404723]
    • 16615: L01406
      Human growth hormone-releasing hormone receptor mRNA, complete cds
      gi|183172|gb|L01406.1|HUMGHRHREC[183172]
    • 16616: L08109
      Human low-affinity Fc-gamma receptor IIC gene, exons 4-7
      gi|183090|gb|L08109.1|HUMGFCIIC[183090]
    • 16617: L08108
      Human low-affinity Fc-receptor IIB gene, exons 4-7
      gi|183089|gb|L08108.1|HUMGFCIIB[183089]
    • 16618: L08107
      Human low-affinity Fc-gamma receptor IIA gene, exons 4-7
      gi|183088|gb|L08107.1|HUMGFCIIA[183088]
    • 16619: M69106
      Human Gata3 enhancer-binding protein mRNA, complete cds
      gi|182999|gb|M69106.1|HUMGATA3BP[182999]
    • 16620: M59216
      Human gamma-aminobutyric acid-A (GABA-A) receptor beta-1 subunit, exon 9
      gi|182921|gb|M59216.1|HUMGABRB15[182921]
    • 16621: M59215
      Human gamma-aminobutyric acid-A (GABA-A) receptor beta-1 subunit, exons 6, 7 and
      8
      gi|182920|gb|M59215.1|HUMGABRB14[182920]
    • 16622: M59214
      Human gamma-aminobutyric acid-A (GABA-A) receptor beta-1 subunit, exon 5
      gi|182919|gb|M59214.1|HUMGABRB13[182919]
    • 16623: M59213
      Human gamma-aminobutyric acid-A (GABA-A) receptor beta-1 subunit, exon 4
      gi|182918|gb|M5923.13|HUMGABRB12[182918]
    • 16624: M59212
      Human gamma-aminobutyric acid-A (GABA-A) receptor beta-1 subunit, exons 1, 2 and
      3
      gi|182917|gb|M59212.1|HUMGABRB11[182917]
    • 16625: M11067
      Human c-fms proto-oncogene, exon 2, partial cds
      gi|182674|gb|M11067.1|HUMFMSB[182674]
    • 16626: M91647
      Human high-affinity Fc IgG receptor gamma polypeptide (FcgammaRI) gene
      gi|182486|gb|M91647.1|HUMFCIGGHC[182486]
    • 16627: M91646
      Human high-affinity Fc IgG receptor gamma polypeptide (FcgammaRI) gene
      gi|182485(gb|M91646.1|HUMFCIGGHB[182485]
    • 16628: M91645
      Human high-affinity Fc IgG receptor gamma polypeptide (FcgammaRI) gene
      gi|182484|gb|M91645.1|HUMFCIGGHA[182484]
    • 16629: L03420
      Human Fc-gamma receptor I B2 mRNA, complete cds
      gi|182461|gb|L03420.1|HUMFCGR1BB[182461]
    • 16630: L03419
      Human Fc-gamma receptor I B1 mRNA, complete cds
      gi|182460|gb|L03419.1|HUMFCGR1B[182460]
    • 16632: L08603
      Human melanocortin 4 receptor gene, complete cds
      gi|291977|gb|L08603.1|HUMEL4REC[182460]
    • 16633: M93111
      Human endothelial cell-derived thrombin receptor cDNA, 5′ additional sequence
      gi|181945 gb|M93111.1|HUMECTR[181945]
    • 16635: M94915
      Human dinucleotide repeat polymorphism gene
      gi|181836|gb|M94915.1|HUMDRP[181836]
    • 16636: L12116
      Homo sapiens dinucleotide polymorphism in the G-protein coupled receptor gene (d20s32e)
      gi|181631|gb|L12116.1|HUMDNP[181631]
    • 16637: M25945
      Human DNA sequence, C-beta locus
      gi|181627|gb|M25945.1|HUMDNAZ[181627]
    • 16639: L22303
      Human dopamine receptor D2 gene, repeat polymorphism
      gi|441061|gb|L22303.1|HUMD2RP[441061]
    • 16640: L23333
      Human corticotropin releasing factor receptor mRNA, complete cds
      gi|408691|gb|L23333.1|HUMCRFRB[408691]
    • 16641: L23332
      Human corticotropin releasing factor receptor mRNA, complete cds
      gi|408689|gb|L23332.1|HUMCRFRA[408689]
    • 16642: M73238
      Human ciliary neurotrophic factor receptor (CNTFR) mRNA, complete cds
      gi|180710|gb|M73238.1|HUMCNTFR[180710]
    • 16643: M63835
      Human IgG Fc receptor I gene, exon 6 and complete cds
      gi|80277|gb|M63835.1|HUMCFCGRI6[180277]
    • 16644: M63834
      Human IgG Fc receptor I gene, exon 5
      gi|180276|gb|M63834.1|HUMCFCGRI5[180276]
    • 16645: M63833
      Human IgG Fc receptor I gene, exon 4
      gi|180275|gb|M63833.1|HUMCFCGRI4[180275]
    • 16646: M63832
      Human IgG Fc receptor I gene, exon 3
      gi|180274|gb|M63832.1|HUMCFCGRI3[180274]
    • 16647: M63831
      Human IgG Fc receptor I gene, exon 2
      gi|180273|gb|M63831.1|HUMCFCGRI2[180273]
    • 16648: M63830
      Human IgG Fc receptor I gene, exon 1
      gi|180272|gb|M63830.1|HUMCFCGRI1[180272]
    • 16649: L13605
      Human cholecystokinin A receptor mRNA, complete cds
      gi|306490|gb|L13605.1|HUMCCKAR[306490]
    • 16650: L08112
      Human brain cholecystokinin-B/gastrin receptor mRNA, complete cds
      gi|306488|gb|L08112.1|HUMCCBGR[306488]
    • 16651: L04473
      Human cholecystokinin receptor mRNA, complete cds
      gi|179997|gb|L04473.1|HUMCCKR[179997]
    • 16652: L00587
      Human calcitonin receptor mRNA, complete cds
      gi|179879|gb|L00587.1|HUMCALREC[179879]
    • 16653: L08893
      Human bombesin receptor subtype-3 mRNA, complete cds
      gi|291876|gb|L08893.1|HUMBOMB3S[291876]
    • 16654: L27594
      Homo sapiens bradykinin B2 receptor gene sequence
      gi|508475|gb|L27594.1|HUMBB2R[508475]
    • 16656: M28639
      Human autoimmune thyroid disease-related antigen mRNA
      gi|291864|gb|M28639.1|HUMATDRAGA[291864]
    • 16657: M91464
      Human angiotensinogen II type-1A receptor gene, complete cds
      gi|179121|gb|M91464.1|HUMAT1A[179121]
    • 16658: M87290
      Human angiotensin II type 1 receptor mRNA, complete cds
      gi|178682|gb|M87290.1|HUMANTIR[178682]
    • 16659: M26228
      Human anti-angiotensinogen mRNA, partial cds
      gi|178641|gb|M26228.1|HUMANGA[178641]
    • 16661: M99590
      Homo sapiens (clone pmt2-huma1b) alpha-1B adrenergic receptor gene sequence
      gi|17821|gb|M99590.1|HUMADRENB[178211]
    • 16663: M93415
      Human activin type II receptor mRNA, complete cds
      gi|178049|gb|M93415.1|HUMACTIIA[178049]
    • 16664: M74954
      Human alpha-5-beta-1 fibronectin receptor
      gi|177940|gb|M74954.1|HUMABFIREC[177940]
    • 16665: L25827
      Human a7 nicotinic acetylcholine receptor mRNA
      gi|438616|gb|L25827.1|HUMA7NAR[438616]
    • 16666: M76446
      Human alpha-A1-adrenergic receptor mRNA, complete cds
      gi|177806|gb|M76446.1|HUMA1AADR[177806]
    • 16667: M89955
      Human 5-HT1D-type serotonin receptor gene, complete cds
      gi|177771|gb|M89955.1|HUM5HT1DA[177771]
    • 16668: M89478
      Human 5-HT1B serotonin receptor gene
      gi|177770|gb|M89478.1|HUM5HT1BSR[177770]
    • 16669: L36162
      Homo sapiens (clone TH3L) receptor tyrosine kinase tire ITT (DTD) mRNA
      gi|537326|gb|L36162.1|HUM3RTK[537326]
    • 16670: L05666
      Homo sapiens NMDA receptor subunit (NR1) mRNA, complete cds
      gi|307302|gb|L05666.1|HUMNMDAREC[307302]
    • 16671: L14865
      Human somatostatin receptor (SST) gene, complete cds
      gi|431094|gb|L14865.1|HUMSST28A[431094]
    • 16672: L24894
      Human myelin protein zero (PO) gene, exon 1
      gi|454413|gb|L24894.1|HUMAAC01[454413]
    • 16673: L24893
      Human myelin protein zero (PO) gene, exons 2, 3, 4, 5, and 6
      gi|454412|gb|L24893.1|HUMAAC02[454412]
    • 16674: L25119
      Human Mu opiate receptor (MOR1) mRNA, complete cds
      gi|452072|gb|L25119.1|HUMMOR1X[452072]
    • 16676: L24804
      Human (p23) mRNA, complete cds
      gi|438651|gb|L24804.1|HUMPRA[438651]
    • 16677: L21954
      Human peripheral benzodiazepine receptor gene, exon 4
      gi|483405|gb|L21954.1|HSPBR4[483405]
    • 16678: L21953
      Human peripheral benzodiazepine receptor gene, exon 3
      gi|483404|gb|L21953.1|HSPBR3[483404]
    • 16679: L21952
      Human peripheral benzodiazepine receptor gene, exon 2
      gi|483403|gb|L21952.1|HSPBR2[483403]
    • 16680: L21951
      Human peripheral benzodiazepine receptor gene, exon 1
      gi|483402|gb|L21951.1|HSPBR1[483402]
    • 16681: L21950
      Human peripheral benzodiazepine receptor related mRNA sequence
      gi|483401|gb|L21950.1|HUMBENZA[483401]
    • 16682: L20817
      Homo sapiens tyrosine protein kinase (CAK) gene, complete cds
      gi|306474|gb|L20817.1|HUMCAK[306474]
    • 16683: L20852
      Human leukemia virus receptor 2 (GLVR2) mRNA, complete cds
      gi|306771|gb|L20852.1|HUMGLVR2X[306771]
    • 16684: L24470
      Homo sapiens prostanoid FP receptor mRNA, complete cds
      gi|456563|gb|L24470.1|HUMPF2AR[456563]
    • 16685: L22214
      Human adenosine A1 receptor (ADORA1) mRNA exons 1-6, complete cds
      gi|347520|gb|L22214.1|HUMADORA1X[347520]
    • 16687: L23503
      Human glucagon-like peptide-1 receptor (GLP-1) mRNA, complete cds
      gi|402480|gb|L23503.1|HUMGLP1R[402480]
    • 16689: L10820
      Human N-formyl peptide receptor (FPR1) gene, complete cds and Alu repeats
      gi|182739|gb|L10820.1|HUMFPR1A[182739]
    • 16690: M99293
      Homo sapiens seven transmembrane segment receptor mRNA, complete cds
      gi|292516|gb|M99293.1|HUMSTSR[292516]
    • 16691: L01639
      Human (clone HSY3RR) neuropeptide Y receptor (NPYR) mRNA, complete cds
      gi|189313|gb|L01639.1|HUMNYRECA[189313]
    • 16692: L20463
      Human A3 adenosine receptor mRNA, complete cds
      gi|349448|gb|L20463.1|HUMA3ADENR[349448]
    • 16693: L19872
      Human AH-receptor mRNA, complete cds
      gi|41614|gb|L19872.1|HUMAHREC[416141]
    • 16694: L17075
      Human TGF-b superfamily receptor type I mRNA, complete cds
      gi|425147|gb|L17075.1|HUMTGFBRS[425147]
    • 16695: L14075
      Homo sapiens immunoglobulin receptor alpha chain gene, complete cds
      gi|410211|gb|L14075.1|HUMIGERA[410211]
    • 16696: L11695
      Human activin receptor-like kinase (ALK-5) mRNA, complete cds
      gi|431034|gb|L11695.1|HUMALK5A[431034]
    • 16697: L22206
  • Human vasopressin receptor V2 gene, complete cds
  • gi|347522|gb|L22206.1|HUMV2R[347522]
    • 16698: M91211
      Human receptor for advanced glycosylation end products (RAGE) mRNA, partial cds
      gi|190845|gb|M91211.1|HUMRAGE[190845]
    • 16699: L20469
      Human truncated dopamine D3 receptor mRNA, complete cds
      gi|306688|gb|L20469.1|HUMD3DR[306688]
    • 16701: L11315
      Homo sapiens receptor tyrosine kinase mRNA, complete cds
      gi|403386|gb|L11315.1|HUMRTK[403386]
    • 16702: L19315
      Human cholecystokinin A receptor mRNA, complete cds
      gi|306595|gb|L19315.1|HUMCHOLREC[306595]
    • 16724: L15310
      Homo sapiens glucagon-like peptide-1 receptor gene
      gi|292051|gb|L15310.1|HUMGLP1RGA[292051]
    • 16725: M99624
      Human epidermal growth factor receptor-related gene, 5′ end
      gi|178251|gb|M99624.1|HUMAGGCRB[178251]-892-Appendix II
    • 1: NM017882
      Homo sapiens ceroid-lipofuscinosis, neuronal 6, late infantile, variant (CLN6),
      mRNA
      gi|8923531|ref|NM017882.1|[8923531]
    • 2: BI480800
      H2RPE-0436 Human Retinal Pigment Epithelium (2) Homo sapiens cDNA 5′ similar to
      glycoprotein (transmembrane) nmb (GPNMB), mRNA sequence
      gi|18998609|gb|BI480800.1|BI480800[18998609]
    • 4: AC096780
      Tcc118, complete sequence
      gi|18958727|gb|AC096780.1|[18958727]
    • 5: AC113243
      Tcc1a22, complete sequence
      gi|18958719|gb|AC113243.1|[18958719]
    • 6: AF347029
      Homo sapiens transmembrane protein (C60RF33) mRNA, complete cds
      gi|18873730|gb|AF347029.1|[18873730]
    • 8: NM001183
      Homo sapiens ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit
      1 (ATP6S1), mRNA
      gi|17136147|ref|NM001183.2|[17136147]
    • 13: NM005765
      Homo sapiens ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane
      sector associated protein M8-9 (ATP6M8-9), mRNA
      gi|15011917|ref|NM005765.2|[15011917]
    • 14: AB028140
      Homo sapiens mRNA for spinesin, complete cds
      gi|12248916|dbj|AB028140.1|[12248916]
    • 15: NM002846
      Homo sapiens protein tyrosine phosphatase, receptor type, N (PTPRN), mRNA
      gi|18860905|ref|NM002846.2|[18860905]
    • 16: NM002845
      Homo sapiens protein tyrosine phosphatase, receptor type, M (PTPRM), mRNA
      gi|18860903|ref|NM002845.2|[18860903]
    • 17: NM002844
      Homo sapiens protein tyrosine phosphatase, receptor type, K (PTPRK), mRNA
      gi|18860901|ref|NM002844.2|[18860901]
    • 18: NM002843
      Homo sapiens protein tyrosine phosphatase, receptor type, J (PTPRJ), mRNA
      gi|18860899|ref|NM002843.2|[18860899]
    • 19: NM002841
      Homo sapiens protein tyrosine phosphatase, receptor type, G (PTPRG), mRNA
      gi|18860897|ref|NM002841.2|[18860897]
    • 20: NM130440
      Homo sapiens protein tyrosine phosphatase, receptor type, F (PTPRF), transcript
      variant 2, mRNA
      gi|18860895|ref|NM130440.1|[18860895]
    • 21: NM130393
      Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript
      variant 4, mRNA
      gi|18860893|ref|NM130393.1|[18860893]
    • 22: NM130392
      Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript
      variant 3, mRNA
      gi|18860891|ref|NM130392.1|[18860891]
    • 23: NM130391
      Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript
      variant 2, mRNA
      gi|18860889|ref|NM130391.1|[18860889]
    • 24: NM002840
      Homo sapiens protein tyrosine phosphatase, receptor type, F (PTPRF), transcript
      variant 1, mRNA
      gi|18860871|ref|NM002840.2|[18860871]
    • 25: NM006504
      Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript
      variant 1, mRNA
      gi|18860860|ref|NM006504.2|[18860860]
    • 26: NM130435
      Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript
      variant 2, mRNA
      gi|18860858|ref|NM130435.1|[18860858]
    • 27: NM002842
      Homo sapiens protein tyrosine phosphatase, receptor type, H (PTPRH), mRNA
      gi|4506312|ref|NM002842.1|[4506312]
    • 28: NM002839
      Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript
      variant 1, mRNA
      gi|4506308|ref|NM002839.1|[4506308]
    • 29: BC024191
      Homo sapiens, Similar to transmembrane protein HTMP10, clone IMAGE:4799785, mRNA
      gi|18848306|gb|BC024191.1[18848306]
    • 30: NM023068
      Homo sapiens sialoadhesin (SN), mRNA
      gi|18765743|ref|NM023068.2|[18765743]
    • 31: NM032646
      Homo sapiens tweety homolog 2 (Drosophila) (TTYH2), mRNA
      gi|17939343|ref|NM032646.4|[17939343]
    • 32: NM022006
      Homo sapiens FXYD domain-containing ion transport regulator 7 (FXYD7), mRNA
      gi|11612658|ref|NM022006.1|[11612658]
    • 33: NM022003
      Homo sapiens FXYD domain-containing ion transport regulator 6 (FXYD6), mRNA
      gi|11612654|ref|NM022003.1|[11612654]
    • 34: NM002127
      Homo sapiens HLA-G histocompatibility antigen, class I, G (HLA-G), mRNA
      gi|18765718|ref|NM002127.2|[18765718]
    • 35: NM005516
      Homo sapiens major histocompatibility complex, class I, E (HLA-E), mRNA
      gi|18765717|ref|NM005516.2|[18765717]
    • 36: NM002121
      Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1),
      mRNA
      gi|18765716|ref|NM002121.3|[18765716]
    • 37: NM006120
      Homo sapiens major histocompatibility complex, class II, DM alpha (HLA-DMA), mRNA
      gi|18765714|ref|NM006120.2|[18765714]
    • 38: NM002116
      Homo sapiens major histocompatibility complex, class I, A (HLA-A), mRNA
      gi|18765713|ref|NM002116.3|[18765713]
    • 39: NM130797
      Homo sapiens dipeptidylpeptidase VI (DPP6), transcript variant 1, mRNA
      gi|18765697|ref|NM130797.1|[18765697]
    • 40: NM001936
      Homo sapiens dipeptidylpeptidase VI (DPP6), transcript variant 2, mRNA
      gi|18765695|ref|NM001936.2|[18765695]
    • 41: NM018593
      Homo sapiens solute carrier family 16 (monocarboxylic acid transporters), member
      10 (SLC16A10), mRNA
      gi|18699729|ref|NM018593.2|[18699729]
    • 42: BM510040
      ig97b09.x1 HR85 islet Homo sapiens cDNA clone IMAGE: 3′ similar to TR:O60478 O60478 PUTATIVE SEVEN PASS TRANSMEMBRANE PROTEIN.;, mRNA sequence
      gi|18681183|gb|BM510040.1|BM510040[18681183]
    • 43: BM509858
      ig94h01.y1 HR85 islet Homo sapiens cDNA clone IMAGE: 5′ similar to SW:MTRP_HUMAN
      Q15012 GOLGI 4-TRANSMEMBRANE SPANNING TRANSPORTER MTP; mRNA sequence
      gi|18681001|gb|BM509858.1|BM509858[18681001]
    • 44: BM509717
      ig93b05.y1 HR85 islet Homo sapiens cDNA clone IMAGE: 5′ similar to SW:MTRP_HUMAN
      Q15012 GOLGI 4-TRANSMEMBRANE SPANNING TRANSPORTER MTP;, mRNA sequence
      gi|18680860|gb|BM509717.1|BM509717[18680860]
    • 45: BM508064
      ij38f06.x1 Human insulinoma Homo sapiens cDNA clone IMAGE:5633410 3′ similar to
      TR:P97544 P97544 ER TRANSMEMBRANE PROTEIN.;, mRNA sequence
      gi|18679207|gb|BM508064.1|BM508064[18679207]
    • 46: NM033543
      Homo sapiens hypothetical protein R291241 (R291241), mRNA
      gi|16117774|ref|NM033543.1|[16117774]
    • 47: NM032732
      Homo sapiens hypothetical protein MGC10763 (IL17RL), mRNA
      gi|14249349|ref|NM032732.1|[14249349]
    • 48: NM018676
      Homo sapiens TMTSP for transmembrane molecule with thrombospondin module (LOC55901), mRNA
      gi|8923893|ref|NM018676.1|[8923893]
    • 49: NM016372
      Homo sapiens seven transmembrane domain orphan receptor (TPRA40), mRNA
      gi|7705964|ref|NM016372.1|[7705964]
    • 50: L47337
      Homo sapiens transmembrane protein (TMC) mRNA, complete cds
      gi|18654193|gb|L47337.1|HUMTMC[18654193]
    • 56: Y13567
      Homo sapiens HLA-B*07022 gene exon 1-5
      gi|4007617|emb|Y13567.1|HSY13567[4007617]
    • 57: NM032027
      Homo sapiens beta-amyloid binding protein precursor (BBP), mRNA
      gi|17738309|ref|NM032027.2|[17738309]
    • 58: NM030913
      Homo sapiens sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C (SEMA6C), mRNA
      gi|16306551|ref|NM030913.2|[16306551]
    • 59: NM021203
      Homo sapiens APMCF1 protein (APMCF1), mRNA
      gi|14917112|ref|NM021203.2|[14917112]
    • 60: NM006854
      Homo sapiens KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 (KDELR2), mRNA
      gi|8051609|ref|NM006854.21[8051609]
    • 61: NM014394
      Homo sapiens growth hormone inducible transmembrane protein (GHITM), mRNA
      gi|7657479|ref|NM014394.1|[7657479]
    • 62: NM014399
      Homo sapiens tetraspan NET-6 protein (NET-6), mRNA
      gi|7657372|ref|NM014399.1|[7657372]
    • 63: NM014478
      Homo sapiens calcitonin gene-related peptide-receptor component protein (CGRP-RCP), mRNA
      gi|7656976|ref|NM014478.1|[7656976]
    • 64: NM007324
      Homo sapiens MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor (MADHIP), transcript variant 1,
      mRNA
      gi|6552338|ref|NM007324.1|[6552338]
    • 65: NM007323
      Homo sapiens MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor (MADHIP), transcript variant 2,
      mRNA
      gi|6552336|ref|NM007323.1|[6552336]
    • 66: NM006876
      Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (B3GNT6), mRNA
      gi|5802983|ref|NM006876.1|[5802983]
    • 67: NM006675
      Homo sapiens tetraspan transmembrane 4 super family (NET-5), mRNA
      gi|5729940|ref|NM006675.1|[5729940]
    • 68: NM006405
      Homo sapiens transmembrane 9 superfamily member 1 (TM9SF1), mRNA
      gi|5453741|ref|NM006405.1|[5453741]
    • 69: NM005761
      Homo sapiens plexin C1 (PLXNC1), mRNA
      gi|5032222|ref|NM005761.1|[5032222]
    • 70: NM005814
      Homo sapiens glycoprotein A33 (transmembrane) (GPA33), mRNA
      gi|5031560|ref|NM005814.1|[5031560]
    • 71: NM004799
      Homo sapiens MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor (MADHIP), transcript variant 3,
      mRNA
      gi|4759059|ref|NM004799.1|[4759059]
    • 72: NM003764
      Homo sapiens syntaxin 11 (STX11), mRNA
      gi|4507286|ref|NM003764.1|[4507286]
    • 73: NM003622
      Homo sapiens PTPRF interacting protein, binding protein 1 (liprin beta 1) (PPFIBP1), mRNA
      gi|4505986|ref|NM003622.1|[4505986]
    • 74: NM003626
      Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),
      interacting protein (liprin), alpha 1 (PPFIA1), mRNA
      gi|4505982|ref|NM003626.1|[4505982]
    • 75: NM033266
      Homo sapiens ER to nucleus signalling 2 (ERN2), mRNA
      gi|15149481|ref|NM033266.1|[15149481]
    • 76: NM030780
      Homo sapiens folate transporter/carrier (LOC81034), mRNA
      gi|13540550|ref|NM030780.1|[13540550]
    • 77: NM025179
      Homo sapiens plexin A2 (PLXNA2), mRNA
      gi|13378152|ref|NM025179.1|[13378152]
    • 78: NM022097
      Homo sapiens hepatocellular carcinoma antigen gene 520 (LOC63928), mRNA
      gi|11545810|ref|NM022097.1|[11545810]
    • 79: NM019111
      Homo sapiens major histocompatibility complex, class II, DR alpha (HLA-DRA), mRNA
      gi|18641378|ref|NM019111.2|[18641378]
    • 80: NM002120
      Homo sapiens major histocompatibility complex, class II, DO beta (HLA-DOB), mRNA
      gi|18641377|ref|NM002120.2|[18641377]
    • 81: NM002118
      Homo sapiens major histocompatibility complex, class II, DM beta (HLA-DMB), mRNA
      gi|18641376|ref|NM002118.3|[18641376]
    • 82: NM002125
      Homo sapiens major histocompatibility complex, class II, DR beta 5 (HLA-DRB5),
      mRNA
      gi|18641374|ref|NM002125.2|[18641374]
    • 83: NM021983
      Homo sapiens major histocompatibility complex, class II, DR beta 4 (HLA-DRB4),
      mRNA
      gi|18641372|ref|NM021983.3|[18641372]
    • 84: NM022555
      Homo sapiens major histocompatibility complex, class II, DR beta 3 (HLA-DRB3),
      mRNA
      gi|18641371|ref|NM022555.3|[18641371]
    • 85: NM080923
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript
      variant 4, mRNA
      gi|18641365|ref|NM080923.1|[18641365]
    • 86: NM080922
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript
      variant 3, mRNA
      gi|18641363|ref|NM080922.1|[18641363]
    • 87: NM080921
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript
      variant 2, mRNA
      gi|18641361|ref|NM080921.1|[18641361]
    • 88: NM130778
      Homo sapiens collagen, type XVII, alpha 1 (COL17A1), transcript variant short,
      mRNA
      gi|18641355|ref|NM130778.1|[18641355]
    • 89: NM000494
      Homo sapiens collagen, type XVII, alpha 1 (COL17A1), transcript variant long, mRNA
      gi|18641353|ref|NM000494.2|[18641353]
    • 90: NM002838
      Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript
      variant 1, mRNA
      gi|18641346|ref|NM002838.2|[18641346]
    • 91: NM030950
      Homo sapiens ret finger protein (RFP), transcript variant beta, mRNA
      gi|18641280|ref|NM030950.2[18641280]
    • 92: NM130785
      Homo sapiens TPTE and PTEN homologous inositol lipid phosphatase (TPIP), mRNA
      gi|18640755|ref|NM130785.1|[18640755]
    • 93: AB057445
      Homo sapiens hTAT1 mRNA for aromatic amino acid transporter, complete cds
      gi|18640046|dbj|AB057445.1|[18640046]
    • 94: NM006510
      Homo sapiens ret finger protein (RFP), transcript variant alpha, mRNA
      gi|17105396|ref|NM006510.3|[17105396]
    • 95: NM033554
      Homo sapiens major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1),
      mRNA
      gi|15809045|ref|NM033554.1|[15809045]
    • 96: NM005608
      Homo sapiens protein tyrosine phosphatase, receptor type, C-associated protein
      (PTPRCAP), mRNA
      gi|5032004|ref|NM005608.1|[5032004]
    • 97: BM491907
      pgp2n.pk007.m20 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk007.m20 5′ similar to gb|AAH17476.1|AAH17476 (BC017476) sema domain, immunoglobulin domain (Ig), transmembrane domain TM) and
      short cytoplasmic domain, (semaphorin) 4C [Homo sapiens], mRNA sequence
      gi|18612838|gb|BM491907.1|BM491907[18612838]
    • 98: BM491823
      pgp2n.pk007.i6 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk007.i6 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II membrane protein [Homo sapiens] dbj|BAA76498.1|(AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18612754|gb|BM491823.1|BM491823[18612754]
    • 99: BM491746
      pgp2n.pk107.f14 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk007.f14 5′ similar to ref|XP044533.2 (XM044533) sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4B [Homo sapiens], mRNA sequence
      gi|18612677|gb|BM491746.1|BM491746[18612677]
    • 100: BM491722
      pgp2n.pk007.d9 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk007.d9 5′ similar to ref|XP032285.1 (XM032285) similar to putative transmembrane protein; homolog of yeast Golgi membrane protein Yif1p (Yip1p-interacting factor) [Homo sapiens], mRNA sequence
      gi|18612653|gb|BM491722.1|BM491722[18612653]
    • 101: BM491453
      pgp2n.pk006.h11 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk006.h11 5′ similar to ref|XP 058189.1 (XM058189) similar to Similar to transmembrane 4 superfamily member 1 (H. sapiens) [Homo sapiens] gb|AAH14339.1|AAH14339 (BC014339) Similar to transmembrane 4 superfamily member 1 [Homo sapiens], mRNA sequence
      gi|18612384|gb|BM491453.1|BM491453[18612384]
    • 102: BM490974
      pgp2n.pk005.a11 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk005.a11 5′ similar to ref|XP008022.1 (XM008022) chromosome 16 open reading frame 5 [Homo sapiens]
      gi|AAG35583.1|AF1956611 (AF195661) transmembrane protein I1 [Homo sapiens]
      gi|AAH02882.1|AAH02882 (BC002882) chromosome 16 open reading frame 5 [Homo sapiens], mRNA sequence
      gi|18611905|gb|BM490974.1|BM490974[18611905]
    • 103: BM490515
      pgp2n.pk003.k2 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk003.k2 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II membrane protein [Homo sapiens] dbj|BAA76498.1|(AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18611446|gb|BM490515.1|BM490515[18611446]
    • 104: BM490496
      pgp2n.pk003.j21 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk003.j21 5′ similar to ref|XP015557.1 (XM015557) transmembrane gamma-carboxyglutamic acid protein 3 [Homo sapiens],
      mRNA sequence
      gi|18611427|gb|BM490496.1|BM490496[18611427]
    • 105: BM490381
      pgp2n.pk003.e10 Normalized Chicken Pituitary/Hypothalamus/Pineal Library (pgp2n)
      Gallus gallus cDNA clone pgp2n.pk003.e10 5′ similar to ref|NP057641.1 (NM016557) orphan seven-transmembrane receptor, chemokine related [Homo sapiens] ref|XP016022.11 (XM016022) orphan seven-transmembrane receptor, chemokine related [Homo sapiens] sp|Q9NPB9|CKRB_HUMAN C-C CHEMOKINE RECEPTOR TYPE, mRNA sequence
      gi|18611312|gb|BM490381.1|BM490381[18611312]
    • 106: BM489618
      pgm2n.pk011.h5 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk011.h5 5′ similar to ref|NP114131.1 (NM031925) transmembrane protein induced by tumor necrosis factor alpha [Homo sapiens] gb|AAK16442.1|AF3279231 (AF327923) transmembrane protein induced by tumor necrosis factor alpha [Homo sapiens], mRNA sequence
      gi|18610549|gb|BM489618.1|BM489618[18610549]
    • 107: BM489501
      pgm2n.pk011.b24 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk011.b24 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II
      membrane protein [Homo sapiens] dbj|BAA76498.1|(AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18610432|gb|BM489501.1|BM489501[18610432]
    • 108: BM489487
      pgm2n.pk011.a8 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk011.a8 5′ similar to gb|AAC64943.1 (AF084481) transmembrane protein [Homo sapiens], mRNA
      sequence
      gi|18610418|gb|BM489487.1|BM489487[18610418]
    • 109: BM489466
      pgm2n.pk010.p5 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk010.p5 5′ similar to dbj|AK056595.1|AK056595 Homo sapiens cDNA FLJ32033 fis, clone NTONG2000265, weakly similar to Probable transmembrane protein of fission yeast,
      mRNA sequence
      gi|18610397|gb|BM489466.1|BM489466[18610397]
    • 110: BM489443
      pgm2n.pk010.o4 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk010.o4 5′ similar to ref|XP008022.1 (XM008022) chromosome 16 open reading frame 5 [Homo sapiens] gb|AAG35583.1|AF1956611 (AF195661) transmembrane protein I1 [Homo sapiens] gb|AAH02882.1|AAH02882 (BC002882) chromosome 16 open reading frame 5 [Homo sapiens], mRNA sequence
      gi|18610374|gb|BM489443.1|BM489443[18610374]
    • 111: BM489432
      pgm2n.pk010.o15 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk010.o15 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II
      membrane protein [Homo sapiens] dbj|BAA76498.11 (AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18610363|gb|BM489432.1|BM489432[18610363]
    • 112: BM489389
      pgm2n.pk010.m15 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk010.m15 5′ similar to ref|XP028438.1 (XM028438) CGI-101 protein [Homo sapiens]
      gi|AAF99603.1|AF2425231 (AF242523) hypothetical transmembrane protein SBB153 [Homo sapiens] gb|AAG43049.1|AF1322891 (AF132289) F-LAN-1 [Homo sapiens]
      gi|AAH10890.1|AAH10890 (BC010890), mRNA sequence
      gi|18610320|gb|BM489389.1|BM489389[18610320]
    • 113: BM489272
      pgm2n.pk010.g4 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk010.g4 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II
      membrane protein [Homo sapiens] dbj|BAA76498.1|(AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18610203|gb|BM489272.1|BM489272[18610203]
    • 114: BM489267
      pgm2n.pk010.g2 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk010.g2 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II
      membrane protein [Homo sapiens] dbj|BAA76498.1|(AB015631) type II membrane protein [Homo sapiens), mRNA sequence
      gi|18610198|gb|BM489267.1|BM489267[18610198]
    • 115: BM488196
      pgm2n.pk006.n2 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk006.n2 5′ similar to ref|NP114434.1 (NM032045) kringle-containing transmembrane protein;
      kringle-coding gene marking the eye and the nose [Homo sapiens] dbj|BAB40969.11
      (AB059618) kringle-containing transmembrane protein [Homo sapiens), mRNA sequence
      gi|18609127|gb|BM488196.1|BM488196[18609127]
    • 116: BM488072
      pgm2n.pk006.h15 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk006.h15 5′ similar to ref|XP044533.2 (XM044533) sema domain, immunoglobulin domain (Ig),
      transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B [Homo sapiens], mRNA sequence
      gi|18609003|gb|BM488072.1|BM488072[18609003]
    • 117: BM487945
      pgm2n.pk006.h16 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk006.b16 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II
      membrane protein [Homo sapiens] dbj|BAA76498.1|(AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18608876|gb|BM487945.1|BM487945[18608876]
    • 118: BM487175
      pgm2n.pk003.m18 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk003.m18 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II
      membrane protein [Homo sapiens] dbj|BAA76498.1|(AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18608105|gb|BM487175.1|BM487175[18608105]
    • 119: BM487035
      pgm2n.pk003.f7 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk003.f7 5′ similar to emb|CAC88191.1 (AL136141) bA138E2.2 (novel protein (lung seven transmembrane receptor 1 (LUSTR1), KIAA1623, FLJ22591, MGC15440)) [Homo sapiens), mRNA sequence
      gi|18607965|gb|BM487035.1|BM487035[18607965]
    • 120: BM486914
      pgm2n.pk003.a11 Normalized Chicken Breast Muscle, Leg Muscle, and Epiphyseal Growth Plate cDNA library (pgm2n) Gallus gallus cDNA clone pgm2n.pk003.a11 5′ similar to ref|NP055070.1 (NM014255) transmembrane protein 4; putative type II
      membrane protein [Homo sapiens] dbj|BAA76498.11 (AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18607844|gb|BM486914.1|BM486914[18607844]
    • 121: NT009151
      Homo sapiens chromosome 11 working draft sequence segment
      gi|18604868|ref|NT009151.8|Hs119308[18604868]
    • 122: NT010823
      Homo sapiens chromosome 17 working draft sequence segment
      gi|18604211|ref|NT010823.8|Hs1710980[18604211]
    • 123: XM008517
      Homo sapiens similar to transmembrane 4 superfamily member 5 (H. sapiens) (LOC147059), mRNA
      gi|18604159|ref|XM008517.4|[18604159]
    • 124: NT009482
      Homo sapiens chromosome 12 working draft sequence segment
      gi|18601829|ref|NT009482.8|Hs129639[18601829]
    • 125: NT009458
      Homo sapiens chromosome 12 working draft sequence segment
      gi|18601539|ref|NT009458.7|Hs129615[18601539]
    • 126: NT005428
      Homo sapiens chromosome 2 working draft sequence segment
      gi|18600405|ref|NT005428.7|Hs25585[18600405]
    • 127: XM087234
      Homo sapiens sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4F (SEMA4F), mRNA
      gi|18600294|ref|XM087234.1|[18600294]
    • 128: NT030593
      Homo sapiens chromosome 2 working draft sequence segment
      gi|18599598|ref|NT030593.2|Hs230849[18599598]
    • 129: XM092364
      Homo sapiens similar to seven transmembrane receptor (LOC165082), mRNA
      gi|18599578|ref|XM092364.1|[18599578]
    • 130: NT025667
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18599563|ref|NT025667.2|Hs325823[18599563]
    • 131: NT010478
      Homo sapiens chromosome 16 working draft sequence segment
      gi|18598685|ref|NT010478.8|Hs1610635[18598685]
    • 132: NT010422
      Homo sapiens chromosome 16 working draft sequence segment
      gi|18598469|ref|NT010422.8|Hs1610579[18598469]
    • 133: NT030136
      Homo sapiens chromosome 14 working draft sequence segment
      gi|18597657|ref|NT030136.3|Hs1430391[18597657]
    • 134: XM090902
      Homo sapiens similar to transmembrane 9 superfamily member 1 (H. sapiens) (LOC161426), mRNA
      gi|18597655|ref|XM090902.1|[18597655]
    • 135: XM085169
      Homo sapiens similar to seven transmembrane receptor BLTR2; leukotriene B4 receptor BLT2 (H. sapiens) (LOC145549), mRNA
      gi|18597626|ref|XM085169.1|[18597626]
    • 136: NT026437
      Homo sapiens chromosome 14 working draft sequence segment
      gi|18597566|ref|NT026437.6|Hs1426604[18597566]
    • 137: XM085149
      Homo sapiens similar to fibronectin leucine rich transmembrane protein 2 (H. sapiens) (LOC145535), mRNA
      gi|18597448|ref|XM085149.1|[18597448]
    • 138: NT025892
      Homo sapiens chromosome 14 working draft sequence segment
      gi|18597282|ref|NT025892.7|Hs1426048[18597282]
    • 139: NT019583
      Homo sapiens chromosome 14 working draft sequence segment
      gi|18596851|ref|NT019583.8|Hs1419739[18596851]
    • 140: XM093204
      Homo sapiens similar to G protein-coupled receptor 64; G protein-coupled receptor, epididymis-specific (seven transmembrane family) (LOC170247), mRNA
      gi|18596481|ref|XM093204.1|[18596481]
    • 141: NT025319
      Homo sapiens chromosome X working draft sequence segment
      gi|18596220|ref|NT025319.8|HsX25475[18596220]
    • 142: NT011719
      Homo sapiens chromosome X working draft sequence segment
      gi|18595448|ref|NT011719.6|HsX11876[18595448]
    • 143: XM093073
      Homo sapiens similar to TRANSMEMBRANE 9 SUPERFAMILY PROTEIN MEMBER 2 PRECURSOR
      (LOC170048), mRNA
      gi|18595444|ref|XM093073.1|[18595444]
    • 144: XM060026
      Homo sapiens similar to transmembrane 9 superfamily member 2; 76 kDa membrane protein; transmembrane protein 9 superfamily member 2 (LOC139375), mRNA
      gi|18595426|ref|XM060026.2|[18595426]
    • 145: NT011687
      Homo sapiens chromosome X working draft sequence segment
      gi|18595291|ref|NT011687.8|HsX11844[18595291]
    • 146: NT011657
      Homo sapiens chromosome X working draft sequence segment
      gi|18595178|ref|NT011657.8|HsX11814[18595178]
    • 147: XM032382
      Homo sapiens transmembrane 4 superfamily member 2 (TM4SF2), mRNA
      gi|18595108|ref|XM032382.3|[18595108]
    • 148: XM055073
      Homo sapiens similar to transmembrane phosphatase with tensin homology (H. sapiens) (LOC150132), mRNA
      gi|18593511|ref|XM055073.3|[18593511]
    • 149: XM009671
      Homo sapiens transmembrane, prostate androgen induced RNA (TMEPAI), mRNA
      gi|18591987|ref|XM009671.7|[18591987]
    • 150: NT011296
      Homo sapiens chromosome 19 working draft sequence segment
      gi|18591133|ref|NT011296.8|Hs1911453[18591133]
    • 151: NT011295
      Homo sapiens chromosome 19 working draft sequence segment
      gi|18591086|ref|NT011295.5|Hs1911452[18591086]
    • 152: NT011294
      Homo sapiens chromosome 19 working draft sequence segment
      gi|18591029|ref|NT011294.7|Hs1911451[18591029]
    • 153: NT011255
      Homo sapiens chromosome 19 working draft sequence segment
      gi|18590680|ref|NT011255.8|HS19 11412[18590680]
    • 154: NT011233
      Homo sapiens chromosome 19 working draft sequence segment
      gi|18590500|ref|NT011233.8|Hs1911390[18590500]
    • 155: XM032285
      Homo sapiens similar to putative transmembrane protein; homolog of yeast Golgi
      membrane protein Yif1p (Yip1p-interacting factor) (LOC90522), mRNA
      gi|18590452|ref|XM032285.2|[18590452]
    • 156: NT011151
      Homo sapiens chromosome 19 working draft sequence segment
      gi|18590324|ref|NT011151.8|Hs1911308[18590324]
    • 157: NT011109
      Homo sapiens chromosome 19 working draft sequence segment
      gi|18589940|ref|NT011109.8|Hs1911266[18589940]
    • 158: NT030157
      Homo sapiens chromosome 17 working draft sequence segment
      gi|18588299|ref|NT030157.3|Hs1730412[18588299]
    • 159: XM096100
      Homo sapiens transmembrane activator and CAML interactor (TACI), mRNA
      gi|18588295|ref|XM096100.1|[18588295]
    • 160: NT010672
      Homo sapiens chromosome 17 working draft sequence segment
      gi|18586808|ref|NT010672.8|Hs1710829[18586808]
    • 161: NT024776
      Homo sapiens chromosome 16 working draft sequence segment
      gi|8585964|ref|NT024776.4|Hs1624932[18585964]
    • 162: NT015360
      Homo sapiens chromosome 16 working draft sequence segment
      gi|18585813|ref|NT015360.8|Hs1615516[18585813]
    • 163: NT010552
      Homo sapiens chromosome 16 working draft sequence segment
      gi|18585429|ref|NT010552.8|Hs1610709[18585429]
    • 164: NT010356
      Homo sapiens chromosome 15 working draft sequence segment
      gi|18584698|ref|NT010356.8|Hs1510513[18584698]
    • 165: NT010351
      Homo sapiens chromosome 15 working draft sequence segment
      gi|18584556|ref|NT010351.8|Hs1510508[18584556]
    • 166: NT010224
      Homo sapiens chromosome 15 working draft sequence segment
      gi|18583998|ref|NT010224.7|Hs1510381[18583998]
    • 167: XM083914
      Homo sapiens transmembrane 6 superfamily member 1 (TM6SF1), mRNA
      gi|18583986|ref|XM083914.1|[18583986]
    • 168: XM083903
      Homo sapiens transmembrane 9 superfamily member 1 (TM9SF1), mRNA
      gi|18583350|ref|XM083903.1|[18583350]
    • 169: NT010036
      Homo sapiens chromosome 14 working draft sequence segment
      gi|18583080|ref|NT010036.8|Hs1410193[18583080]
    • 170: XM028295
      Homo sapiens calponin like transmembrane domain protein (calmin), mRNA
      gi|18582992|ref|XM028295.3|[18582992]
    • 171: NT029430
      Homo sapiens chromosome 13 working draft sequence segment
      gi|18582622|ref|NT029430.4|Hs1329589[18582622]
    • 172: NT009967
      Homo sapiens chromosome 13 working draft sequence segment
      gi|18582005|ref|NT009967.8|Hs1310124[18582005]
    • 173: NT009952
      Homo sapiens chromosome 13 working draft sequence segment
      gi|18581926|ref|NT009952.8|Hs1310109[18581926]
    • 174: NT009917
      Homo sapiens chromosome 13 working draft sequence segment
      gi|18581517(ref|NT009917.8|Hs1310074[18581517]
    • 175: XM084974
      Homo sapiens transmembrane phosphatase with tensin homology (TPTE), mRNA
      gi|18581435|ref|XM084974.1|[18581435]
    • 176: NT009910
      Homo sapiens chromosome 13 working draft sequence segment
      gi|18581383|ref|NT009910.8|Hs1310067[18581383]
    • 177: NT009711
      Homo sapiens chromosome 12 working draft sequence segment
      gi|18580591|ref|NT009711.8|Hs129868[18580591]
    • 178: NT009540
      Homo sapiens chromosome 12 working draft sequence segment
      gi|18579972|ref|NT009540.8|Hs129697[18579972]
    • 179: NT009487
      Homo sapiens chromosome 12 working draft sequence segment
      gi|18579817|ref|NT009487.8|Hs129644[18579817]
    • 180: XM084852
      Homo sapiens similar to transmembrane protein induced by tumor necrosis factor
      alpha (LOC144404), mRNA
      gi|18579801|ref|XM084852.1|[18579801]
    • 181: NT009471
      Homo sapiens chromosome 12 working draft sequence segment
      gi|18579778|ref|NT009471.8|Hs129628[18579778]
    • 182: XM084845
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U) (LOC144383), mRNA
      gi|18579688|ref|XM084845.1|[18579688]
    • 183: XM006748
      Homo sapiens seven transmembrane protein TM7SF3 (TM7SF3), mRNA
      gi|18579647|ref|XM006748.5|[18579647]
    • 184: NT030809
      Homo sapiens chromosome 12 working draft sequence segment
      gi|18579377|ref|NT030809.2|Hs1231065[18579377]
    • 185: NT024394
      Homo sapiens chromosome 12 working draft sequence segment
      gi|18579035|ref|NT024394.7|Hs1224550[18579035]
    • 186: NT009237
      Homo sapiens chromosome 11 working draft sequence segment
      gi|18578641|ref|NT009237.8|Hs119394[18578641]
    • 187: NT009215
      Homo sapiens chromosome 11 working draft sequence segment
      gi|18578584|ref|NT009215.8|Hs119372[18578584]
    • 188: NT008992
      Homo sapiens chromosome 11 working draft sequence segment
      gi|18578338|ref|NT008992.7|Hs119149[18578338]
    • 189: XM055266
      Homo sapiens putative transmembrane protein; homolog of yeast Golgi membrane protein Yif1p (Yip1p-interacting factor) (54TM), mRNA
      gi|18578177|ref|XM055266.2|[18578177]
    • 190: XM045525
      Homo sapiens transmembrane 7 superfamily member 2 (TM7SF2), mRNA
      gi|18578063|ref|XM045525.4|[18578063]
    • 191: XM006111
      Homo sapiens fibronectin leucine rich transmembrane protein 1 (FLRT1), mRNA
      gi|18578050|ref|XM006111.5|[18578050]
    • 192: NT008804
      Homo sapiens chromosome 10 working draft sequence segment
      gi|18576536|ref|NT008804.8|Hs108961[18576536]
    • 193: XM084484
      Homo sapiens similar to sema domain, immunoglobulin domain (Ig), transmembrane
      domain (TM) and short cytoplasmic domain, (semaphorin) 4G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4G (LOC143288), mRNA
      gi|18576428|ref|XM084484.1|[18576428]
    • 194: NT008609
      Homo sapiens chromosome 10 working draft sequence segment
      gi|18575857|ref|NT008609.8|Hs108766[18575857]
    • 195: NT029394
      Homo sapiens chromosome 10 working draft sequence segment
      gi|185745771 ref|NT029394.3|Hs1029553[18574577]
    • 196: NT024089
      Homo sapiens chromosome 10 working draft sequence segment
      gi|8574182|ref|NT024089.8|Hs1024245[18574182]
    • 197: NT024064
      Homo sapiens chromosome 10 working draft sequence segment
      gi|18574077|ref|NT024064.8|Hs1024220[18574077]
    • 198: XM084331
      Homo sapiens similar to growth hormone inducible transmembrane protein (H. sapiens) (LOC170427), mRNA
      gi|18574063|ref|XM084331.1|[18574063]
    • 199: XM043589
      Homo sapiens growth hormone inducible transmembrane protein (GHITM), mRNA
      gi|8574061|ref|XM043589.3|[18574061]
    • 200: NT008554
      Homo sapiens chromosome 9 working draft sequence segment
      gi|8573734|ref|NT008554.8|HS98711[18573734]
    • 201: XM071188
      Homo sapiens similar to mucin 1, transmembrane (LOC138940), mRNA
      gi|18573702|ref|XM071188.2|[18573702]
    • 202: NT008476
      Homo sapiens chromosome 9 working draft sequence segment
      gi|18573649|ref|NT008476.8|HS98633[18573649]
    • 203: NT008421
      Homo sapiens chromosome 9 working draft sequence segment
      gi|18573390|ref|NT008421.8|Hs98578[18573390]
    • 204: NT031831
      Homo sapiens chromosome 9 working draft sequence segment
      gi|18572946|ref|NT031831.1|Hs932002[18572946]
    • 205: NT031830
      Homo sapiens chromosome 9 working draft sequence segment
      gi|18572933|ref|NT031830.1|HS932001[18572933]
    • 206: NT029366
      Homo sapiens chromosome 9 working draft sequence segment
      gi|18572447|ref|NT029366.4|Hs929525[18572447]
    • 207: NT027082
      Homo sapiens chromosome 9 working draft sequence segment
      gi|18572282|ref|NT027082.5|Hs927242[18572282]
    • 208: NT024010
      Homo sapiens chromosome 9 working draft sequence segment
      gi|18572162|ref|NT024010.7|Hs924166[18572162]
    • 209: XM108898
      Homo sapiens sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4D (SEMA4D), mRNA
      gi|18572160|ref|XM108898.1|[18572160]
    • 210: NT023967
      Homo sapiens chromosome 9 working draft sequence segment
      gi|18571929|ref|NT023967.8|Hs924123[18571929]
    • 211: XM095756
      Homo sapiens similar to transmembrane protein 2 (H. sapiens) (LOC169529), mRNA
      gi|18571901|ref|XM095756.1|[18571901]
    • 212: NT008253
      Homo sapiens chromosome 8 working draft sequence segment
      gi|18571429|ref|NT008253.8|Hs88410[18571429]
    • 213: NT008079
      Homo sapiens chromosome 8 working draft sequence segment
      gi|18570812|ref|NT008079.8|Hs88236[18570812]
    • 214: NT007997
      Homo sapiens chromosome 8 working draft sequence segment
      gi|8570417|ref|NT007997.8|Hs88154[18570417]
    • 215: XM095564
      Homo sapiens similar to transmembrane trafficking protein (LOC169193), mRNA
      gi|18570401|ref|XM095564.1|[18570401]
    • 216: NT007978
      Homo sapiens chromosome 8 working draft sequence segment
      gi|18570256|ref|NT007978.8|Hs88135[18570256]
    • 217: NT030735
      Homo sapiens chromosome 8 working draft sequence segment
      gi|18569963|ref|NT030735.2|Hs830991[18569963]
    • 218: NT007905
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18568542|ref|NT007905.8Hs78062[18568542]
    • 219: NT007902
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18568515|ref|NT007902.8|Hs78059[18568515]
    • 220: AF132746
      Homo sapiens transmembrane protein mRNA, complete cds
      gi|18568116|gb|AF132746.1|[18568116]
    • 221: NT007867
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18568101|ref|NT007867.8|Hs78024[18568101]
    • 222: NT007751
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18567173|ref|NT007751.8|Hs77908[18567173]
    • 223: NT031815
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18566709|ref|NT031815.1|Hs731986[18566709]
    • 224: NT031811
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18566667|ref|NT031811.1Hs731982[18566667]
    • 225: XM095132
      Homo sapiens similar to dM538M10.1 (novel 7 transmembrane receptor (rhodopsin family) (olfactory receptor like) protein similar to human HS6M1-21) (LOC154958), mRNA
      gi|18566661|ref|XM095132.1|[18566661]
    • 226: NT031807
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18566613|ref|NT031807.1|Hs731978[18566613]
    • 227: NT030004
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18566403|ref|NT030004.3|Hs730259[18566403]
    • 228: NT027064
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18566143|ref|NT027064.5|Hs727224[18566143]
    • 229: NT017168
      Homo sapiens chromosome 7 working draft sequence segment
      gi|18565551|ref|NT017168.8|Hs717324[18565551]
    • 230: NT007592
      Homo sapiens chromosome 6 working draft sequence segment
      gi|18565438|ref|NT007592.8|Hs67749[18565438]
    • 231: XM094938
      Homo sapiens similar to 573K1.2 (mm17M1-3 (novel 7 transmembrane receptor (rhodopsin family) (olfactory receptor LIKE) protein)) (LOC168233), mRNA
      gi|18565395|ref|XM094938.1|[18565395]
    • 232: XM094903
      Homo sapiens similar to 573K1.15 (mm17M1-6 (novel 7 transmembrane receptor (rhodopsin family) (olfactory receptor LIKE) protein)) (LOC168189), mRNA
      gi|18565249|ref|XM094903.1|[18565249]
    • 233: XM094939
      Homo sapiens similar to dM538M10.7 (novel 7 transmembrane receptor (rhodopsin family) (olfactory receptor like) protein) (LOC154634), mRNA
      gi|18565093|ref|XM094939.1|[18565093]
    • 234: NT007402
      Homo sapiens chromosome 6 working draft sequence segment
      gi|18564193|ref|NT007402.8|Hs67559[18564193]
    • 235: XM069322
      Homo sapiens similar to transmembrane protein 2 (LOC135381), mRNA
      gi|18564165|ref|XM069322.2|[18564165]
    • 236: XM087914
      Homo sapiens similar to dJ402H5.1 (novel 7 transmembrane receptor of the rhodopsin family) (LOC154354), mRNA
      gi|18564052|ref|XM087914.1|[18564052]
    • 237: XM087917
      Homo sapiens similar to embryonic seven-span transmembrane protein-like protein
      (LOC154344), mRNA
      gi|18564031|ref|XM087917.1|[18564031]
    • 238: XM094741
      Homo sapiens similar to 573K1.15 (mm17M1-6 (novel 7 transmembrane receptor (rhodopsin family) (olfactory receptor LIKE) protein)) (LOC167905), mRNA
      gi|18563541|ref|XM094741.1|[18563541]
    • 239: NT025741
      Homo sapiens chromosome 6 working draft sequence segment
      gi|18563240|ref|NT025741.7|Hs625897[18563240]
    • 240: NT023451
      Homo sapiens chromosome 6 working draft sequence segment
      gi|18563080|ref|NT023451.8|Hs623607[18563080]
    • 241: XM069021
      Homo sapiens similar to putative transmembrane protein PTG (L1C134801) mRNA
      gi|18563039|ref|XM069021.2|[18563039]
    • 242: NT006725
      Homo sapiens chromosome 5 working draft sequence segment
      gi|18561712|ref|NT006725.8|Hs56882[18561712]
    • 243: XM094515
      Homo sapiens similar to transmembrane receptor Unc5H1 (LOC167476), mRNA
      gi|18561698|ref|XM094515.1|[18561698]
    • 244: NT006576
      Homo sapiens chromosome 5 working draft sequence segment
      gi|18561313|ref|NT006576.8|Hs56733[18561313]
    • 245: XM004042
      Homo sapiens sema domain, seven thrombospondin repeats (type 1 and type 1-like),
      transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (SEMA5A), mRNA
      gi|18561264|ref|XM004042.7|[18561264]
    • 246: XM087665
      Homo sapiens similar to semaphorin 6A1; sema domain, transmembrane domain (TM),
      and cytoplasmic domain, 6A; semaphorin 6A-1 (LOC153420), mRNA
      gi|18560683|ref|XM087665.1|[18560683]
    • 247: NT006169
      Homo sapiens chromosome 4 working draft sequence segment
      gi|18558377|ref|NT006169.8|Hs46326[18558377]
    • 248: NT022836
      Homo sapiens chromosome 4 working draft sequence segment
      gi|18557125|ref|NT022836.7|Hs422992[18557125]
    • 249: XM093891
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U) (LOC166482), mRNA
      gi|18557119|ref|XM093891.1|[18557119]
    • 250: AF456925
      Homo sapiens USH3 region, partial sequence
      gi|17901944|gb|AF456925.1|AF411849S2[17901944]
    • 251: AF411849
      Homo sapiens USH3 region, partial sequence
      gi|17901943|gb|AF411849.1|AF411849S1]17901943]
    • 252: AH011260
      Homo sapiens
      gi|17901942|gb|AH011260.1|SEG_AF411849S[17901942]
    • 253: XM064062
      Homo sapiens similar to putative transmembrane receptor (LOC124274), mRNA
      gi|17488065|ref|XM064062.1|[17488065]
    • 254: XM063875
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U) (LOC123862), mRNA
      gi|17487213|ref|XM063875.1|[17487213]
    • 255: XM066655
      Homo sapiens similar to G protein-coupled receptor 64; G protein-coupled receptor, epididymis-specific (seven transmembrane family) (LOC139378), mRNA
      gi|17485715|ref|XM066655.1|[17485715]
    • 256: NT011519
      Homo sapiens chromosome 22 working draft sequence segment
      gi|17484914|ref|NT011519.9|Hs2211676[17484914]
    • 257: NT011362
      Homo sapiens chromosome 20 working draft sequence segment
      gi|17484369|ref|NT011362.7|Hs2011519[17484369]
    • 258: XM063355
      Homo sapiens similar to transmembrane 7 superfamily member 1 (upregulated in kidney); transmembrane 7 superfamily member 1 (upregulated in (LOC122791), mRNA
      gi|17476790|ref|XM063355.1|[17476790]
    • 259: XM062544
      Homo sapiens similar to transmembrane protein 4; putative secreted protein ZSIG9 (LOC121255), mRNA
      gi|17474559|ref|XM062544.1|[17474559]
    • 260: XM062443
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U) (LOC121062), mRNA
      gi|17474137|ref|XM062443.1|[17474137]
    • 261: XM070446
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U) (LOC137474), mRNA
      gi|17466780|ref|XM070446.1|[17466780]
    • 262: XM070130
      Homo sapiens similar to transmembrane protein 4; putative secreted protein ZSIG9
      (LOC136903), mRNA
      gi|17465836|ref|XM070130.1|[17465836]
    • 263: XM069635
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U) (LOC135982), mRNA
      gi|17465065|ref|XM069635.1|[17465065]
    • 264: XM069633
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U); interferon-inducible (LOC135976), mRNA
      gi|17465055|ref|XM069633.1|[17465055]
    • 265: XM069470
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U) (LOC135637), mRNA
      gi|17464370|ref|XM069470.1|[17464370]
    • 266: XM069460
      Homo sapiens similar to dM538M10.7 (novel 7 transmembrane receptor (rhodopsin family) (olfactory receptor like) protein) (LOC135626), mRNA
      gi|17464346|ref|XM069460.1|[17464346]
    • 267: XM064220
      Homo sapiens similar to putative transmembrane receptor (LOC124601), mRNA
      gi|17457972|ref|XM064220.1|[17457972]
    • 268: XM063652
      Homo sapiens similar to leucine zipper-EF-hand containing transmembrane protein
      1; leucine zipper-EF-hand containing transmembrane protein 1 (LOC123430), mRNA
      gi|17456715|ref|XM063652.1|[17456715]
    • 269: XM062703
      Homo sapiens similar to tetraspan transmembrane 4 super family (LOC121590), mRNA
      gi|17456679|ref|XM062703.1|[17456679]
    • 270: XM051362
      Homo sapiens transmembrane 6 superfamily member 2 (TM6SF2), mRNA
      gi|17456138|ref|XM051362.2|[17456138]
    • 271: NT011288
      Homo sapiens chromosome 19 working draft sequence segment
      gi|17455923|ref|NT011288.7|HS1911445[17455923]
    • 272: XM031933
      Homo sapiens transmembrane protein vezatin (VEZATIN), mRNA
      gi|17454769|ref|XM031933.3|[17454769]
    • 273: XM068785
      Homo sapiens similar to transmembrane receptor Unc5H1 (LOC13430i), mRNA
      gi|17446928|ref|XM068785.1|[17446928]
    • 274: NT030685
      Homo sapiens chromosome 5 working draft sequence segment
      gi|17443457|ref|NT030685.1Hs530941[17443457]
    • 275: NT011387
      Homo sapiens chromosome 20 working draft sequence segment
      gi|16195112|ref|NT011387.6|Hs2011544[16195112]
    • 276: NT011512
      Homo sapiens chromosome 21 working draft sequence segment
      gi|16170824|ref|NT011512.4|Hs2111669[16170824]
    • 277: XM049793
      Homo sapiens transmembrane protease, serine 2 (TMPRSS2), mRNA
      gi|16170797|ref|XM049793.2|[16170797]
    • 278: NT011520
      Homo sapiens chromosome 22 working draft sequence segment
      gi|16168698|ref|NT011520.8|Hs2211677[16168698]
    • 279: NT030188
      Homo sapiens chromosome 21 working draft sequence segment
      gi|16166749|ref|NT030188.1|Hs2130443[16166749]
    • 280: NT029490
      Homo sapiens chromosome 21 working draft sequence segment
      gi|16166567|ref|NT029490.2|Hs2129649[16166567]
    • 281: NT011515
      Homo sapiens chromosome 21 working draft sequence segment
      gi|16166537|ref|NT011515.6|Hs2111672[16166537]
    • 282: XM009794
      Homo sapiens transmembrane protein 1 (TMEM1), mRNA
      gi|16166381|ref|XM009794.4|[16166381]
    • 283: NT009407
      Homo sapiens chromosome 11 working draft sequence segment
      gi|16164445|ref|NT009407.5|Hs119564[16164445]
    • 284: NT027220
      Homo sapiens chromosome X working draft sequence segment
      gi|16163830|ref|NT027220.2|HsX27380[16163830]
    • 285: XM055222
      Homo sapiens region containing sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G; mitochondrial ribosomal protein L32 (LOC143289), mRNA
      gi|16156787|ref|XM055222.1|[16156787]
    • 286: XM008123
      Homo sapiens tryptase gamma 1 (TPSG1), mRNA
      gi|15317318|ref|XM008123.5|[15317318]
    • 287: NT009738
      Homo sapiens chromosome 12 working draft sequence segment
      gi|15307319|ref|NT009738.5|HS129895[15307319]
    • 288: XM006991
      Homo sapiens tetraspan transmembrane 4 super family (NET-5), mRNA
      gi|15307297|ref|XM006991.5|[15307297]
    • 289: NT009513
      Homo sapiens chromosome 12 working draft sequence segment
      gi|15303938|ref|NT009513.5|Hs129670[15303938]
    • 290: NT029317
      Homo sapiens chromosome 6 working draft sequence segment
      gi|15300889|ref|NT029317.1|Hs629476[15300889]
    • 291: XM040419
      Homo sapiens transmembrane trafficking protein (TMP21), mRNA
      gi|14784589|ref|XM040419.1|[14784589]
    • 292: XM030300
      Homo sapiens similar to transmembrane receptor Unc5H1 (LOC90249), mRNA
      gi|14781377|ref|XM030300.1|[14781377]
    • 293: XM036570
      Homo sapiens type I transmembrane protein Fn14 (FN14), mRNA
      gi|14777984|ref|XM036570.1|[14777984]
    • 294: XM027469
      Homo sapiens transmembrane protein 8 (five membrane-spanning domains) (TMEM8),
      mRNA
      gi|14777199|ref|XM027469.1|[14777199]
    • 295: XM009839
      Homo sapiens claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) (CLDN5), mRNA
      gi|14777026|ref|XM009839.4|[14777026]
    • 296: NT025911
      Homo sapiens chromosome 17 working draft sequence segment
      gi|14776336|ref|NT025911.3|Hs1726067[14776336]
    • 297: XM041427
      Homo sapiens transmembrane protease, serine 5 (spinesin) (TMPRSS5), mRNA
      gi|14770562|ref|XM041427.1|[14770562]
    • 298: XM006940
      Homo sapiens cytoskeleton-associated protein 4 (CKAP4), mRNA
      gi|14766392|ref|XM006940.4|[14766392]
    • 299: NT011598
      Homo sapiens chromosome X working draft sequence segment
      gi|14759313|ref|NT011598.4|HsX11755[14759313]
    • 300: XM033157
      Homo sapiens transmembrane 4 superfamily member 6 (TM4SF6), mRNA
      gi|14757314|ref|XM033157.1|[14757314]
    • 301: XM044358
      Homo sapiens similar to cleft lip and palate associated transmembrane protein (LOC92330), mRNA
      gi|14755905|ref|XM044358.1|[14755905]
    • 302: XM004980
      Homo sapiens cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) (CFTR), mRNA
      gi|14753226|ref|XM004980.4|[14753226]
    • 303: XM002838
      Homo sapiens similar to orphan seven-transmembrane receptor, chemokine related
      (H. sapiens) (LOC154103), mRNA
      gi|14750021|ref|XM002838.6|[14750021]
    • 304: XM005949
      Homo sapiens sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4G (SEMA4G), mRNA
      gi|14747317|ref|XM005949.4|[14747317]
    • 305: XM035329
      Homo sapiens similar to transmembrane trafficking protein (LOC90981), mRNA
      gi|14744677|ref|XM035329.1|[14744677]
    • 306: XM038156
      Homo sapiens transmembrane protein 2 (TMEM2), mRNA
      gi|14743733|ref|XM038156.1|[14743733]
    • 307: XM005346
      Homo sapiens transmembrane protein with EGF-like and two follistatin-like domains 1 (TMEFF1), mRNA
      gi|14738782|ref|XM005346.4|[14738782]
    • 308: XM045505
      Homo sapiens transmembrane 4 superfamily member (tetraspan NET-7) (NET-7), mRNA
      gi|14738519|ref|XM045505.1|[14738519]
    • 311: NT026472
      Homo sapiens chromosome 17 working draft sequence segment
      gi|13654226|ref|NT026472.1|Hs1726639[13654226]
    • 312: XM012718
      Homo sapiens secreted and transmembrane 1 (SECTM1), mRNA
      gi|13654161|ref|XM012718.2|[13654161]
    • 313: XM016506
      Homo sapiens fibronectin leucine rich transmembrane protein 2 (FLRT2), mRNA
      gi|13648109|ref|XM016506.1|[13648109]
    • 314: XM005187
      Homo sapiens ankyrin-like with transmembrane domains 1 (ANKTM1), mRNA
      gi|13645787|ref|XM005187.3|[13645787]
    • 315: NT025803
      Homo sapiens chromosome 8 working draft sequence segment
      gi|13642635|ref|NT025803.2|Hs825959[13642635]
    • 316: XM017003
      Homo sapiens interferon induced transmembrane protein 3 (1-8U) (IFITM3), mRNA
      gi|13642630|ref|XM017003.1|[13642630]
    • 317: NT022761
      Homo sapiens chromosome 4 working draft sequence segment
      gi|18556805|ref|NT022761.8|Hs422917[18556805]
    • 318: XM093853
      Homo sapiens similar to transmembrane tryptase (LOC166415), mRNA
      gi|18556799|ref|XM093853.1|[18556799]
    • 319: NT005997
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18556520|ref|NT005997.8|Hs36154[18556520]
    • 320: XM087464
      Homo sapiens similar to transmembrane protein 7 (LOC152408), mRNA
      gi|18556483|ref|XM087464.1|[18556483]
    • 321: NT005986
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18556440|ref|NT005986.8|Hs36143[18556440]
    • 322: NT005678
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18555423|ref|NT005678.7|Hs35835[18555423]
    • 323: XM093638
      Homo sapiens similar to orphan seven transmembrane receptor (LOC166071), mRNA
      gi|18555421|ref|XM093638.1|[18555421]
    • 324: XM093637
      Homo sapiens similar to orphan seven transmembrane receptor (LOC166070), mRNA
      gi|18555419|ref|XM093637.1|[18555419]
    • 325: NT005654
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18555355|ref|NT005654.8|Hs35811[18555355]
    • 326: NT005616
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18555281|ref|NT005616.8|Hs35773[18555281]
    • 327: NT005543
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18555061|ref|NT005543.7|Hs35700[18555061]
    • 328: XM098155
      Homo sapiens similar to seven transmembrane domain orphan receptor (H. sapiens)
      (LOC152010), mRNA
      gi|18555022|ref|XM098155.1|[18555022]
    • 329: NT022531
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18554079|ref|NT022531.4|Hs322687[18554079]
    • 330: XM096181
      Homo sapiens transmembrane 4 superfamily member 4 (TM4SF4), mRNA
      gi|18554072|ref|XM096181.1|[18554072]
    • 331: NT022412
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18553606|ref NT022412.6|Hs322568[18553606]
    • 332: NT 022393
      Homo sapiens chromosome 3 working draft sequence segment
      gi|18553572|ref|NT022393.7|Hs322549[18553572]
    • 333: NT005423
      Homo sapiens chromosome 2 working draft sequence segment
      gi|18553407|ref|NT005423.8|Hs25580[18553407]
    • 334: NT005387
      Homo sapiens chromosome 2 working draft sequence segment
      gi|18553071|ref|NT005387.8|Hs25544[18553071]
    • 335: NT005289
      Homo sapiens chromosome 2 working draft sequence segment
      gi|18552655|ref|NT005289.8|Hs25446[18552655]
    • 336: NT005214
      Homo sapiens chromosome 2 working draft sequence segment
      gi|18552351|ref|NT005214.8|Hs25371[18552351]
    • 337: NT005138
      Homo sapiens chromosome 2 working draft sequence segment
      gi|18552129|ref|NT005138.8|Hs25295[18552129]
    • 338: NT 022180
      Homo sapiens chromosome 2 working draft sequence segment
      gi|18550124|ref|NT022180.8|Hs222336[18550124]
    • 339: NT004858
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18549451|ref|NT004858.8|Hs15015[18549451]
    • 340: XM053256
      Homo sapiens mucin 1, transmembrane (MUC1), mRNA
      gi|18549380|ref|XM053256.4|[18549380]
    • 341: NT004836
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18549182|ref|NT004836.8|Hs14993[18549182]
    • 342: NT004811
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18549145|ref|NT004811.8|Hs14968[18549145]
    • 343: XM041879
      Homo sapiens similar to AF1Q protein; transmembrane protein (LOC149430), mRNA
      gi|18549121|ref|XM041879.2|[18549121]
    • 344: NT004668
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18548894|ref|NT004668.8|Hs14825[18548894]
    • 345: NT004441
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18547758|ref|NT004441.8|Hs14598[18547758]
    • 346: NT004434
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18547724|ref|NT004434.8|Hs14591[18547724]
    • 347: NT004391
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18547557|ref|NT004391.8|Hs14548[18547557]
    • 348: NT021907
      Homo sapiens chromosome 1 working draft sequence segment
      gi|18544452|ref|NT021907.8|Hs122063[18544452]
    • 349: XM053163
      Homo sapiens sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C (SEMA6C), mRNA
      gi|18544383|ref|XM053163.4|[18544383]
    • 350: NM016155
      Homo sapiens matrix metalloproteinase 17 (membrane-inserted) (MMP17), mRNA
      gi|18543372|ref|NM016155.2|[18543372]
    • 351: XM060507
      Homo sapiens similar to putative integral membrane transporter; lysosomal associated transmembrane protein 4 beta (LOC127480), mRNA
      gi|17443784|ref|XM060507.1|[17443784]
    • 352: XM060501
      Homo sapiens similar to bM332P19.3 (novel 7 transmembrane receptor (rhodopsin family) (olfactory receptor like) protein (mm17M1-14)) (LOC127469), mRNA
      gi|17443690|ref|XM060501.1|[17443690]
    • 353: XM060442
      Homo sapiens similar to interferon induced transmembrane protein 3 (1-8U); interferon-inducible (LOC127360), mRNA
      gi|17441370|ref|XM060442.1|[17441370]
    • 354: XM065294
      Homo sapiens similar to Transmembrane protease, serine 3 (Serine protease TADG-12) (Tumor associated differentially-expressed gene-12 protein) (LOC129566), mRNA
      gi|17439790|ref|XM065294.1|[17439790]
    • 355: XM032249
      Homo sapiens sema domain, seven thrombospondin repeats (type 1 and type 1-like),
      transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B (SEMA5B), mRNA
      gi|17438489|ref|XM032249.3|[17438489]
    • 356: XM058189
      Homo sapiens similar to TRANSMEMBRANE 4 SUPERFAMILY, MEMBER 1 (TUMOR-ASSOCIATED
      ANTIGEN L6) (MEMBRANE COMPONENT, SURFACE MARKER 1) (M3S1) (LOC116441), mRNA
      gi|17437690|ref|XM058189.2|[17437690]
    • 357: NT011903
      Homo sapiens chromosome Y working draft sequence segment
      gi|17433681|ref|NT011903.8|HsY12060[17433681]
    • 358: XM034757
      Homo sapiens similar to transmembrane phosphatase with tensin homology (H. sapiens) (LOC159185), mRNA
      gi|16164045|ref|XM034757.2|[16164045]
    • 359: XM003025
      Homo sapiens mucin 13, epithelial transmembrane (MUC13), mRNA
      gi|16159511|ref|XM003025.5|[16159511]
    • 360: NT015169
      Homo sapiens chromosome 4 working draft sequence segment
      gi|16156888|ref|NT015169.5|Hs415325[16156888]
    • 361: NM002837
      Homo sapiens protein tyrosine phosphatase, receptor type, B (PTPRB), mRNA
      gi|18491009|ref|NM002837.2|[18491009]
    • 362: BC022439
      Homo sapiens, interferon induced transmembrane protein 3 (1-8U), clone MGC:24755
      IMAGE:4282809, mRNA, complete cds
      gi|18490258|gb|BC022439.1|[18490258]
    • 363: NM005031
      Homo sapiens FXYD domain containing ion transport regulator 1 (phospholemman) (FXYD1), transcript variant a, mRNA
      gi|11612671|ref|NM005031.2|[11612671]
    • 364: NM021902
      Homo sapiens FXYD domain containing ion transport regulator 1 (phospholemman) (FXYD1), transcript variant b, mRNA
      gi|11612669|ref|NM021902.1|[11612669]
    • 365: NM014164
      Homo sapiens FXYD domain-containing ion transport regulator 5 (FXYD5), mRNA
      gi|11612664|ref|NM014164.2|[11612664]
    • 366: NM020399
      Homo sapiens PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10 (PIST), mRNA
      gi|9966876|ref|NM020399.1|[9966876]
    • 367: BM439879
      pgr1n.pk001.i17 Normalized Chicken Reproductive Tract cDNA Library (pgr1n) Gallus gallus cDNA clone pgr1n.pk001.i17 5′ similar to gi|7657373 ref|NP055214.11 tetraspan NET-6 protein; transmembrane 4 superfamily protein [Homo sapiens] gi|13628481 ref|XP004793.31 tetraspan NET-6 protein [Homo sapiens] gi|14747013 ref|XP049585.11 tetraspan NET-6 protein [Homo sapiens]
      gi|14, mRNA sequence
      gi|18470654|gb|BM439879.1|BM439879[18470654]
    • 368: BM439852
      pgr1n.pk001.h13 Normalized Chicken Reproductive Tract cDNA Library (pgr1n) Gallus gallus cDNA clone pgr1n.pk001.h13 5′ similar to gi|7657176 ref|NP055070.1|transmembrane protein 4; putative type II membrane protein [Homo sapiens] dbj|BAA76498.1|(AB015631) type II membrane protein [Homo sapiens], mRNA sequence
      gi|18470627|gb|BM439852.1|BM439852[18470627]
    • 369: BM439375
      pgr1c.pk001.a9 Primary Chicken Reproductive Tract cDNA Library (pgr1c) Gallus gallus cDNA clone pgr1c.pk001.a9 5′ similar to gi|13994300 ref|NP114131.1] transmembrane protein induced by tumor necrosis factor alpha [Homo sapiens] gi|AAK16442.1|AF3279231 (AF327923) transmembrane protein induced by tumor necrosis factor alpha [Homo sapiens], mRNA sequence
      gi|18470150|gb|BM439375.1|BM439375[18470150]
    • 370: NM080841
      Homo sapiens protein tyrosine phosphatase, receptor type, A (PTPRA), transcript
      variant 3, mRNA
      gi|18450370|ref|NM080841.1|[18450370]
    • 371: NM080840
      Homo sapiens protein tyrosine phosphatase, receptor type, A (PTPRA), transcript
      variant 2, mRNA
      gi|18450368|ref|NM080840.1|[18450368]
    • 372: NM002836
      Homo sapiens protein tyrosine phosphatase, receptor type, A (PTPRA), transcript
      variant 1, mRNA
      gi|18450367|ref|NM002836.2|[18450367]
    • 373: NM018490
      Homo sapiens G protein-coupled receptor 48 (GPR48), mRNA
      gi|8923700|ref|NM018490.1|[8923700]
    • 374: NM006065
      Homo sapiens signal-regulatory protein beta 1 (SIRPB1), mRNA
      gi|5174678|ref|NM006065.1|[5174678]
    • 375: NM004648
      Homo sapiens protein tyrosine phosphatase, non-receptor type substrate 1 (PTPNS1), mRNA
      gi|4758977|ref|NM004648.1|[4758977]
    • 376: NM003667
      Homo sapiens G protein-coupled receptor 49 (GPR49), mRNA
      gi|4504378|ref|NM003667.1|[4504378]
    • 377: BM427439
      pgf2n.pk006.m15 Normalized Chicken Abdominal Fat Library (pgf2n) Gallus gallus
      cDNA clone pgf2n.pk006.m15 5′ similar to gi|13994300 ref|NP114131.11 transmembrane protein induced by tumor necrosis factor alpha [Homo sapiens] gi|AAK16442.1|AF3279231 (AF327923) transmembrane protein induced by tumor necrosis factor alpha [Homo sapiens], mRNA sequence
      gi|18432616|gb|BM427439.1|BM427439[18432616]
    • 378: BM427410
      pgf2n.pk006.k5 Normalized Chicken Abdominal Fat Library (pgf2n) Gallus gallus cDNA clone pgf2n.pk006.k5 5′ similar to gi|13994300 ref|NP114131.1|transmembrane protein induced by tumor necrosis factor alpha [Homo sapiens] gi|AAK16442.1|AF3279231 (AF327923) transmembrane protein induced by tumor necrosis factor alpha [Homo sapiens], mRNA sequence
      gi|18432562|gb|BM427410.1|BM427410[18432562]
    • 379: BM427358
      pgf2n.pk006.i13 Normalized Chicken Abdominal Fat Library (pgf2n) Gallus gallus
      cDNA clone pgf2n.pk006.i13 5′ similar to gi|7705965 ref|NP057456.11 seven transmembrane domain orphan receptor [Homo sapiens] dbj|BAA89782.1|(AB037108)
      seven transmembrane domain orphan receptor [Homo sapiens], mRNA sequence
      gi|18432475|gb|BM427358.1|BM427358[18432475]
    • 380: NM002122
      Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1),
      mRNA
      gi|18426974|ref|NM002122.2|[18426974]
    • 381: NM080815
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 19, mRNA
      gi|18426960|ref|NM080815.1|[18426960]
    • 382: NM080814
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 18, mRNA
      gi|18426958|ref|NM080814.1|[18426958]
    • 383: NM080813
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 17, mRNA
      gi|18426956|ref|NM080813.1|[18426956]
    • 384: NM080812
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 16, mRNA
      gi|18426954|ref|NM080812.1|[18426954]
    • 385: NM080811
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 15, mRNA
      gi|18426952|ref|NM080811.1|[18426952]
    • 386: NM080810
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 14, mRNA
      gi|18426950|ref|NM080810.1|[18426950]
    • 387: NM080809
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 13, mRNA
      gi|18426948|ref|NM080809.1|[18426948]
    • 388: NM080808
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 12, mRNA
      gi|18426946|ref|NM080808.1|[18426946]
    • 389: NM080807
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 11, mRNA
      gi|18426944|ref|NM080807.1|[18426944]
    • 390: NM080806
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 10, mRNA
      gi|18426942|ref|NM080806.1|[18426942]
    • 391: NM080805
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 9, mRNA
      gi|18426940|ref|NM080805.1|[18426940]
    • 392: NM080804
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 8, mRNA
      gi|18426938|ref|NM080804.1|[18426938]
    • 393: NM080803
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 7, mRNA
      gi|18426936|ref|NM080803.1|[18426936]
    • 394: NM080802
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 6, mRNA
      gi|18426934|ref|NM080802.1|[18426934]
    • 395: NM080801
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 5, mRNA
      gi|18426932|ref|NM080801.1|[18426932]
    • 396: NM080800
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 4, mRNA
      gi|18426930|ref|NM080800.1|[18426930]
    • 397: NM080799
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 3, mRNA
      gi|18426928|ref|NM080799.1|[18426928]
    • 398: NM080798
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 2, mRNA
      gi|18426926|ref|NM080798.1|[18426926]
    • 399: NM005203
      Homo sapiens collagen, type XIII, alpha 1 (COL13A1), transcript variant 1, mRNA
      gi|18426924|ref|NM005203.2|[18426924]
    • 400: NM080792
      Homo sapiens brain-immunoglobulin-like molecule with tyrosine-based activation
      motifs (BIT), mRNA
      gi|18426910|ref|NM080792.1|[8426910]
    • 401: NM080816
      Homo sapiens signal-regulatory protein beta 2 (SIRPB2), transcript variant 2, mRNA
      gi|18426908|ref|NM080816.1|[18426908]
    • 402: NM018556
      Homo sapiens signal-regulatory protein beta 2 (SIRPB2), transcript variant 1, mRNA
      gi|18426907|ref|NM018556.2|[18426907]
    • 406: AF367761
      Homo sapiens transmembrane protein HTMP10 (HTMP10) mRNA, complete cds
      gi|16356924|gb|AF367761.2|[16356924]
    • 409: NM002124
      Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1),
      mRNA
      gi|4504410|ref|NM002124.1|[4504410]
    • 411: NM016235
      Homo sapiens G protein-coupled receptor, family C, group 1, member B (GPRC5B),
      mRNA
      gi|7706450|ref|NM016235.1|[7706450]
    • 412: NM003105
      Homo sapiens sortilin-related receptor, L(DLR class) A repeats-containing (SORL1), mRNA
      gi|18379347|ref|NM003105.3|[18379347]
    • 413: NM004843
      Homo sapiens class I cytokine receptor (WSX1), mRNA
      gi|18379338|ref|NM004843.2|[18379338]
    • 414: AF450008
      Homo sapiens CFTR-associated ligand (CAL) mRNA, complete cds
      gi|17865153|gb|AF450008.1|AF450008[17865153]
    • 415: NM033056
      Homo sapiens protocadherin 15 (PCDH15), mRNA
      gi|16933554|ref|NM033056.2|[16933554]
    • 416: NM022349
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 6A (MS4A6A), mRNA
      gi|11641258|ref|NM022349.1|[11641258]
    • 417: NM005438
      Homo sapiens FOS-like antigen 1 (FOSL1), mRNA
      gi|4885242|ref|NM005438.1|[4885242]
    • 418: BC021208
      Homo sapiens, leucine zipper-EF-hand containing transmembrane protein 1, clone
      MGC:12631 IMAGE:4126510, mRNA, complete cds
      gi|18204588|gb|BC021208.1|BC021208[18204588]
    • 419: BC021557
      Homo sapiens, transmembrane protein 8 (five membrane-spanning domains), clone MGC:31822 IMAGE:4899167, mRNA, complete cds
      gi|18204291|gb|BC021557.1|BC021557[18204291]
    • 420: BC020870
      Homo sapiens, fibronectin leucine rich transmembrane protein 3, clone MGC:24073
      IMAGE: A 6065852, mRNA, complete cds
      gi|18088787|gb|BC020870.1|BC020870[18088787]
    • 421: BC020960
      Homo sapiens, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4G, clone MGC:8849 IMAGE:3851526, mRNA, complete cds
      gi|18088075|gb|BC020960.1|BC020960[18088075]
    • 422: AF444779
      Homo sapiens myocyte inner nuclear membrane protein (MYNE1) mRNA, complete cds
      gi|17227153|gb|AF444779.1|AF444779[17227153]
    • 423: AF329637
      Homo sapiens mitofusin 1 mRNA, nuclear gene for mitochondrial protein, complete
      cds
      gi|12744895|gb|AF329637.1|AF329637[12744895]
    • 424: NM019074
      Homo sapiens delta-like 4 (Drosophila) (DLL4), mRNA
      gi|9506544|ref|NM019074.1|[9506544]
    • 425: NM017789
      Homo sapiens sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4C (SEMA4C), mRNA
      gi|8923345|ref|NM017789.1|[8923345]
    • 426: NM003836
      Homo sapiens delta-like 1 homolog (Drosophila) (DLK1), mRNA
      gi|4503338|ref|NM003836.1|[4503338]
    • 427: NM024021
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 4 (MS4A4A), mRNA
      gi|13430865|ref|NM024021.1|[13430865]
    • 432: NM021950
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of
      IgE, high affinity I, receptor for; beta polypeptide) (MS4A1), mRNA
      gi|11386186|ref|NM021950.1|[11386186]
    • 433: AY046529
      Homo sapiens melanocortin 1 receptor mutant V122M (MC1R) gene, complete cds
      gi|18138241|gb|AY046529.1|[18138241]
    • 434: AY046528
      Homo sapiens melanocortin 1 receptor mutant 140T (MC1R) gene, complete cds
      gi|18138239|gb|AY046528.1|[18138239]
    • 436: AY028261
      Homo sapiens delta transmembrane LIGHT mRNA, complete cds, alternatively spliced
      gi|14278834|gb|AY028261.1|[14278834]
    • 437: AF296875
      Gallus gallus fas ligand receptor soluble form mRNA, partial cds
      gi|993164|gb|AF296875.1|AF296875[9931641]
    • 439: BM315073
      ig43b07.y1 HR85 islet Homo sapiens cDNA 5′ similar to SW:MTRP_HUMAN Q15012 GOLGI
      4-TRANSMEMBRANE SPANNING TRANSPORTER MTP;, mRNA sequence
      gi|18049418|gb|BM315073.1|BM315073[18049418]
    • 440: BM314493
      ig51c05.y1 HR85 islet Homo sapiens cDNA 5′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|18048838|gb|BM314493.1|BM314493[18048838]
    • 441: BM313985
      ih05d09.y1 Human insulinoma Homo sapiens cDNA 5′ similar to SW:MTRP_HUMAN
      Q15012 GOLGI 4-TRANSMEMBRANE SPANNING TRANSPORTER MTP;, mRNA sequence
      gi|18048330|gb|BM313985.1|BM313985[18048330]
    • 442: AF267740
      Homo sapiens transmembrane protein H4 mRNA, complete cds
      gi|18032260|gb|AF267740.1|AF267740[18032260]
    • 443: AF350504
      Homo sapiens four-span transmembrane protein 4 (4SPAN4) mRNA, complete cds
      gi|18028935|gb|AF350504.1|AF350504[18028935]
    • 444: AF350503
      Homo sapiens four-span transmembrane protein 3.2 (4SPAN3) mRNA, complete cds
      gi|18028933|gb|AF350503.1|AF350503[18028933]
    • 445: AF350502
      Homo sapiens four-span transmembrane protein 3.1 (4SPAN3) mRNA, complete cds
      gi|1802893|gb|AF350502.1|AF350502[18028931]
    • 446: AF350501
      Homo sapiens four-span transmembrane protein 2 (4SPAN2) mRNA, complete cds
      gi|18028929|gb|AF350501.1|AF350501[18028929]
    • 447: AF350500
      Homo sapiens four-span transmembrane protein 1 (4SPAN1) mRNA, complete cds
      gi|18028927|gb|AF350500.1|AF350500[18028927]
    • 448: NM078470
      Homo sapiens COX15 homolog, cytochrome c oxidase assembly protein (yeast) (COX15), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA
      gi|17921984|ref|NM078470.1|[17921984]
    • 449: NM004375
      Homo sapiens COX11 homolog, cytochrome c oxidase assembly protein (yeast) (COX11), nuclear gene encoding mitochondrial protein, mRNA
      gi|17921983|ref|NM004375.2|[17921983]
    • 450: NM001303
      Homo sapiens COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (COX10), nuclear gene encoding mitochondrial protein, mRNA
      gi|17921981|ref|NM001303.2|[17921981]
    • 451: NM031999
      Mus musculus transmembrane 7 superfamily member 1 (Tm7sf1), mRNA
      gi|14269573|ref|NM031999.1|[14269573]
    • 452: NM020659
      Homo sapiens tweety homolog 1 (Drosophila) (TTYH1), mRNA
      gi|10257436|ref|NM020659.1|[10257436]
    • 453: NM052945
      Homo sapiens BAFF receptor (BAFFR), mRNA
      gi|17978517|ref|NM052945.2|[17978517]
    • 454: NM078481
      Homo sapiens CD97 antigen (CD97), transcript variant 1, mRNA
      gi|17978490|ref|NM078481.1|[17978490]
    • 455: NM001784
      Homo sapiens CD97 antigen (CD97), transcript variant 2, mRNA
      gi|17978488|ref|NM001784.2|[17978488]
    • 456: NM1004444
      Homo sapiens EphB4 (EPHB4), mRNA
      gi|17975769|ref|NM004444.2|[17975769]
    • 457: NM004443
      Homo sapiens EphB3 (EPHB3), mRNA
      gi|17975767|ref|NM004443.2|[17975767]
    • 458: NM004442
      Homo sapiens EphB2 (EPHB2), transcript variant 1, mRNA
      gi|17975766|ref|NM004442.2|[17975766]
    • 459: NM017449
      Homo sapiens EphB2 (EPHB2), transcript variant 2, mRNA
      gi|17975764|ref|NM017449.1|[17975764]
    • 460: BM273281
      if28f09.y1 Melton Normalized Human Islet 4 N4-HIS 1 Homo sapiens cDNA 5′ similar
      to TR:Q9Z112 Q9Z112 SEVEN TRANSMEMBRANE DOMAIN ORPHAN RECEPTOR.;, mRNA sequence
      gi|17966574|gb|BM273281.1|BM273281[17966574]
    • 461: BM271899
      ig36e08.y1 HR85 islet Homo sapiens cDNA 5′ similar to SW:MTRP_HUMAN Q15012 GOLGI
      4-TRANSMEMBRANE SPANNING TRANSPORTER MTP;, mRNA sequence
      gi|17965175|gb|BM271899.1|BM271899[17965175]
    • 462: BM271817
      ig35e06.y1 HR85 islet Homo sapiens cDNA 5′ similar to SW:MTRP_HUMAN Q15012 GOLGI
      4-TRANSMEMBRANE SPANNING TRANSPORTER MTP;, mRNA sequence
      gi|1796509|gb|BM271817.1|BM271817[17965091]
    • 463: BM271771
      ig38h09.x1 HR85 islet Homo sapiens cDNA 3′ similar to TR:O08721 O08721 TRANSMEMBRANE RECEPTOR UNC5H1.;, mRNA sequence
      gi|17965045|gb|BM271771.1|BM271771[17965045]
    • 464: BC019314
      Homo sapiens, transmembrane 4 superfamily member 7, clone MGC:4337 IMAGE:2821236, mRNA, complete cds
      gi|17939509|gb|BC019314.1|BC019314[17939509]
    • 465: BM263743
      ig29h12.y1 HR85 islet Homo sapiens cDNA 5′ similar to SW:NMB_HUMAN Q14956 PUTATIVE TRANSMEMBRANE PROTEIN NMB PRECURSOR.;, mRNA sequence
      gi|17926783|gb|BM263743.1|BM263743[17926783]
    • 466: NM004376
      Homo sapiens COX15 homolog, cytochrome c oxidase assembly protein (yeast) (COX15), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA
      gi|17921986|ref|NM004376.2|[17921986]
    • 467: AY062295
      Homo sapiens prolactin receptor (PRLR) mRNA, partial cds; alternatively spliced
      gi|17887307|gb|AY062295.1|[17887307]
    • 468: NM078474
      Homo sapiens BBP-like protein 2 (BLP2), transcript variant 1, mRNA
      gi|17865799|ref|NM078474.1|[17865799]
    • 469: NM025141
      Homo sapiens BBP-like protein 2 (BLP2), transcript variant 2, mRNA
      gi|17865798|ref|NM025141.2|[17865798]
    • 470: NM078473
      Homo sapiens BBP-like protein 1 (BLP1), transcript variant 1, mRNA
      gi|17865796|ref|NM078473.1|[17865796]
    • 471: NM031940
      Homo sapiens BBP-like protein 1 (BLP1), transcript variant 2, mRNA
      gi|17865794|ref|NM031940.2|[17865794]
    • 472: NM003728
      Homo sapiens unc-5 homolog B (C. elegans) (UNC5C), mRNA
      gi|16933524|ref|NM003728.2|[16933524]
    • 473: NM054027
      Homo sapiens ankylosis, progressive homolog (mouse) (ANKH), transcript variant
      2, mRNA
      gi|16905506|ref|NM054027.1|[16905506]
    • 474: NM019847
      Homo sapiens ankylosis, progressive homolog (mouse) (ANKH), transcript variant
      1, mRNA
      gi|16905505|ref|NM019847.3|[16905505]
    • 475: NM018440
      Homo sapiens phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), mRNA
      gi|16753228|ref|NM018440.2|[16753228]
    • 478: NM019894
      Homo sapiens transmembrane protease, serine 4 (TMPRSS4), mRNA
      gi|15451939|ref|NM019894.1|[15451939]
    • 479: NM006577
      Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1), transcript variant 1, mRNA
      gi|15451893|ref|NM006577.3|[15451893]
    • 480: NM033252
      Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1), transcript variant 2, mRNA
      gi|15451863|ref|NM033252.1|[15451863]
    • 481: NM014302
      Homo sapiens Sec61 gamma (SEC61G), mRNA
      gi|14591933|ref|NM014302.2|[14591933]
    • 482: NM014459
      Homo sapiens protocadherin 17 (PCDH17), mRNA
      gi|14589926|ref|NM014459.2|[14589926]
    • 483: NM032961
      Homo sapiens protocadherin 10 (PCDH10), transcript variant 1, mRNA
      gi|14589915|ref|NM032961.1|[14589915]
    • 484: NM020815
      Homo sapiens protocadherin 10 (PCDH10), transcript variant 2, mRNA
      gi|14589913|ref|NM020815.1|[14589913]
    • 485: NM032966
      Homo sapiens Burkitt lymphoma receptor 1, GTP binding protein (BLR1), transcript
      variant 2, mRNA
      gi|14589868|ref|NM032966.1|[14589868]
    • 486: NM001716
      Homo sapiens Burkitt lymphoma receptor 1, GTP binding protein (BLR1), transcript
      variant 1, mRNA
      gi|14589867|ref|NM001716.2|[14589867]
    • 487: NM031866
      Homo sapiens trizzled homolog 8 (Drosophila) (FZD8), mRNA
      gi|13994189|ref|NM031866.1|[13994189]
    • 488: NM030770
      Homo sapiens transmembrane protease, serine 5 (spinesin) (TMPRSS5), mRNA
      gi|13540534|ref|NM030770.1|[13540534]
    • 489: NM001407
      Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog,
      Drosophila) (CELSR3), mRNA
      gi|13325065|ref|NM001407.1|[13325065]
    • 490: NM001408
      Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog,
      Drosophila) (CELSR2), mRNA
      gi|13325063|ref|NM001408.1|[13325063]
    • 491: NM005971
      Homo sapiens FXYD domain-containing ion transport regulator 3 (FXYD3), transcript variant 1, mRNA
      gi|11612675|ref|NM005971.2|[11612675]
    • 492: NM021910
      Homo sapiens FXYD domain-containing ion transport regulator 3 (FXYD3), transcript variant 2, mRNA
      gi|11612673|ref|NM021910.1|[11612673]
    • 493: NM021778
      Homo sapiens a disintegrin and metalloproteinase domain 28 (ADAM28), transcript
      variant 2, mRNA
      gi|11496995|ref|NM021778.1|[11496995]
    • 494: NM021777
      Homo sapiens a disintegrin and metalloproteinase domain 28 (ADAM28), transcript
      variant 3, mRNA
      gi|11496993|ref|NM021777.1|[11496993]
    • 495: NM021783
      Homo sapiens ectodysplasin A2 isoform receptor (XEDAR), mRNA
      gi|11140822|ref|NM021783.1|[11140822]
    • 496: NM020182
      Homo sapiens transmembrane, prostate androgen induced RNA (TMEPAI), mRNA
      gi|9910497|ref|NM020182.1|[9910497]
    • 497: NM003857
      Homo sapiens galanin receptor 2 (GALR2), mRNA
      gi|8051600|ref|NM003857.21[8051600]
    • 498: NM015727
      Homo sapiens tachykinin receptor 1 (TACR1), transcript variant short, mRNA
      gi|7669545|ref|NM015727.1|[7669545]
    • 499: NM001058
      Homo sapiens tachykinin receptor 1 (TACR1), transcript variant long, mRNA
      gi|7669544|ref|NM001058.2|[7669544]
    • 501: NM014246
      Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog,
      Drosophila) (CELSR1), mRNA
      gi|7656966|ref|NM014246.1|[7656966]
    • 502: NM014265
      Homo sapiens a disintegrin and metalloproteinase domain 28 (ADAM28), transcript
      variant 1, mRNA
      gi|7656862|ref|NM014265.1|[7656862]
    • 503: NM007264
      Homo sapiens adrenomedullin receptor (ADMR), mRNA
      gi|6466448|ref|NM007264.2|[6466448]
    • 504: NM004733
      Homo sapiens acetyl-Coenzyme A transporter (ACATN), mRNA
      gi|6042194|ref|NM004733.2|[6042194]
    • 505: NM003801
      Homo sapiens GPAA1P anchor attachment protein 1 homolog (yeast) (GPAA1), mRNA
      gi|6031166|ref|NM003801.2|[6031166]
    • 506: NM007197
      Homo sapiens frizzled homolog 10 (Drosophila) (FZD10), mRNA
      gi|6005761|ref|NM007197.1|[6005761]
    • 507: NM001466
      Homo sapiens frizzled homolog 2 (Drosophila) (FZD2), mRNA
      gi|5922012|ref|NM001466.21[5922012]
    • 508: NM006579
      Homo sapiens emopamil binding protein (sterol isomerase) (EBP), mRNA
      gi|5729809|ref|NM006579.1|[5729809]
    • 509: NM006017
      Homo sapiens prominin-like 1 (mouse) (PROML1), mRNA
      gi|5174386|ref|NM006017.1|[5174386]
    • 510: NM005228
      Homo sapiens epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (EGFR), mRNA
      gi|4885198|ref|NM005228.1|[4885198]
    • 511: NM004617
      Homo sapiens transmembrane 4 superfamily member 4 (TM4SF4), mRNA
      gi|4759239|ref|NM004617.1|[4759239]
    • 512: NM004787
      Homo sapiens slit homolog 2 (Drosophila) (SLIT2), mRNA
      gi|4759145|ref|NM004787.1|[4759145]
    • 513: NM004445
      Homo sapiens EphB6 (EPHB6), mRNA
      gi|4758291|ref|NM004445.1|[4758291]
    • 514: NM004338
      Homo sapiens chromosome 18 open reading frame 1 (C18orf1), mRNA
      gi|4757883|ref|NM004338.1|[4757883]
    • 515: NM002982
      Homo sapiens small inducible cytokine A2 (monocyte chemotactic protein 1) (SCYA2), mRNA
      gi|4506840|ref|NM002982.1|[4506840]
    • 516: NM002944
      Homo sapiens v-ros UR2 sarcoma virus oncogene homolog 1 (avian) (ROS1), mRNA
      gi|4506578|ref|NM002944.1|[4506578]
    • 517: NM000264
      Homo sapiens patched homolog (Drosophila) (PTCH), mRNA
      gi|4506246|ref|NM000264.1|[4506246]
    • 518: NM003508
      Homo sapiens frizzled homolog 9 (Drosophila) (FZD9), mRNA
      gi|4503834|ref|NM003508.1|[4503834]
    • 519: NM003507
      Homo sapiens frizzled homolog 7 (Drosophila) (FZD7), mRNA
      gi|4503832|ref|NM003507.1|[4503832]
    • 520: NM003506
      Homo sapiens frizzled homolog 6 (Drosophila) (FZD6), mRNA
      gi|4503830|ref|NM003506.1|[4503830]
    • 521: NM003468
      Homo sapiens frizzled homolog 5 (Drosophila) (FZD5), mRNA
      gi|4503828|ref|NM003468.1|[4503828]
    • 522: NM003505
      Homo sapiens frizzled homolog 1 (Drosophila) (FZD1), mRNA
      gi|4503824|ref|NM003505.1|[4503824]
    • 523: NM001982
      Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
      (ERBB3), mRNA
      gi|4503596|ref|NM001982.1|[4503596]
    • 524: NM003859
      Homo sapiens dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit (DPM1), mRNA
      gi|4503362|ref|NM003859.1|[4503362]
    • 525: NM003915
      Homo sapiens copine I (CPNE1), mRNA
      gi|4503012|ref|NM003915.1|[4503012]
    • 527: NM052959
      Homo sapiens pannexin 3 (PANX3), mRNA
      gi|16418452|ref|NM052959.1|[16418452]
    • 528: NM052859
      Homo sapiens putative endoplasmic reticulum multispan transmembrane protein (RFT1), mRNA
      gi|16418360|ref|NM052859.1|[16418360]
    • 531: NM032108
      Homo sapiens sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B (SEMA6B), mRNA
      gi|14165267|ref|NM032108.1|[14165267]
    • 532: NM031925
      Homo sapiens transmembrane protein induced by tumor necrosis factor alpha (TMPIT), mRNA
      gi|13994299|ref|NM031925.1|[13994299]
    • 533: NM030960
      Homo sapiens sperm acrosome associated 1 (SPACA1), mRNA
      gi|13569933|ref|NM030960.1|[13569933]
    • 534: NM030755
      Homo sapiens thioredoxin domain-containing (TXNDC), mRNA
      gi|13559515|ref|NM030755.1|[13559515]
    • 535: NM024734
      Homo sapiens calponin like transmembrane domain protein (calmin), mRNA
      gi|13376053|ref|NM024734.1|[13376053]
    • 536: NM023003
      Homo sapiens transmembrane 6 superfamily member 1 (TM6SF1), mRNA
      gi|13194198|ref|NM023003.1|[13194198]
    • 537: NM021034
      Homo sapiens interferon induced transmembrane protein 3 (1-8U) (IFITM3), mRNA
      gi|11995467|ref|NM021034.1|[11995467]
    • 538: NM006435
      Homo sapiens interferon induced transmembrane protein 2 (1-8D) (IFITM2), mRNA
      gi|10835237|ref|NM006435.1|[0835237]
    • 539: NM016326
      Homo sapiens chemokine-like factor 1 (CKLF1), mRNA
      gi|10092611|ref|NM016326.2|[10092611]
    • 540: NM016951
      Homo sapiens chemokine-like factor 1 (CKLF1), mRNA
      gi|10092593|ref|NM016951.2|[10092593]
    • 541: NM000888
      Homo sapiens integrin, beta 6 (ITGB6), mRNA
      gi|9966771|ref|NM000888.3|[9966771]
    • 542: NM020241
      Homo sapiens sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B (SEMA6B), mRNA
      gi|9910379|ref|NM020241.1|[9910379]
    • 543: NM018407
      Homo sapiens putative integral membrane transporter (LC27), mRNA
      gi|8923827|ref|NM018407.1|[8923827]
    • 544: NM017514
      Homo sapiens SEX gene (HSSEXGENE), mRNA
      gi|8923792|ref|NM017514.1|[8923792]
    • 545: NM017893
      Homo sapiens sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4G (SEMA4G), mRNA
      gi|8923550|ref|NM017893.1|[8923550]
    • 546: NM017599
      Homo sapiens transmembrane protein vezatin (VEZATIN), mRNA
      gi|8922162|ref|NM017599.1|[8922162]
    • 547: NM014254
      Homo sapiens transmembrane protein 5 (TMEM5), mRNA
      gi|7657177|ref|NM014254.1|[7657177]
    • 548: NM012339
      Homo sapiens transmembrane 4 superfamily member (tetraspan NET-7) (NET-7), mRNA
      gi|6912529|ref|NM012339.1|[6912529]
    • 549: NM012338
      Homo sapiens transmembrane 4 superfamily member (tetraspan NET-2) (NET-2), mRNA
      gi|6912527|ref|NM012338.1|[6912527]
    • 550: NM002673
      Homo sapiens plexin B1 (PLXNB1), mRNA
      gi|6631105|ref|NM002673.1|[6631105]
    • 551: NM006825
      Homo sapiens cytoskeleton-associated protein 4 (CKAP4), mRNA
      gi|5803112|ref|NM006825.1|[5803112]
    • 552: NM004785
      Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 (SLC9A3R2), mRNA
      gi|4759141|ref|NM004785.1|[4759141]
    • 553: NM004263
      Homo sapiens sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4F (SEMA4F), mRNA
      gi|4759093|ref|NM004263.1|[4759093]
    • 554: NM004800
      Homo sapiens transmembrane 9 superfamily member 2 (TM9SF2), mRNA
      gi|4758873|ref|NM004800.1|[4758873]
    • 555: NM000950
      Homo sapiens proline-rich Gla (G-carboxyglutamic acid) polypeptide 1 (PRRG1), mRNA
      gi|4506134|ref|NM000950.1|[4506134]
    • 556: NM003625
      Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),
      interacting protein (liprin), alpha 2 (PPFIA2), mRNA
      gi|4505984|ref|NM003625.1|[4505984]
    • 558: NM032518
      Homo sapiens collagen-like Alzheimer amyloid plaque component precursor (LOC84570), mRNA
      gi|14210525|ref|NM032518.1|[14210525]
    • 559: NM023945
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 5 (MS4A5), mRNA
      gi|12965204|ref|NM023945.1|[12965204]
    • 560: NM016158
      Homo sapiens erythrocyte transmembrane protein (LOC51145), % T
      gi|7705856|ref|NM016158.1|[7705856]
    • 561: AK056649
      Homo sapiens cDNA FLJ32087 fis, clone OCBBF2000467, highly similar to Fibronectin leucine rich transmembrane protein 2
      gi|16552109|dbj|AK056649.1|AK056649[16552109]
    • 562: AK056595
      Homo sapiens cDNA FLJ32033 fis, clone NTONG2000265, weakly similar to Probable
      transmembrane protein of fission yeast
      gi|16552042|dbj|AK056595.1|AK056595[16552042]
    • 563: AK055648
      Homo sapiens cDNA FLJ31086 fis, clone IMR321000044, highly similar to Human transmembrane receptor precursor (PTK7) mRNA
      gi|16550428|dbj|AK055648.1|AK055648[16550428]
    • 564: AK055208
      Homo sapiens cDNA FLJ30646 fis, clone CTONG2004716, weakly similar to Rattus norvegicus mRNA for seven transmembrane receptor
      gi|16549884|dbj|AK055208.1|AK055208[16549884]
    • 565: AK054712
      Homo sapiens cDNA FLJ30150 fis, clone BRACE2000300, highly similar to TRANSMEMBRANE PROTEIN PFT27
      gi|16549313|dbj|AK054712.1|AK054712[16549313]
    • 566: AK054646
      Homo sapiens cDNA FLJ30084 fis, clone BGGI12001682, highly similar to Homo sapiens transmembrane protein TENB2 (TENB2) mRNA
      gi|16549231|dbj|AK054646.1|AK054646[16549231]
    • 567: NM019035
      Homo sapiens protocadherin 18 (PCDH18), mRNA
      gi|14589928|ref|NM019035.1|[14589928]
    • 568: NM030943
      Homo sapiens amnionless protein (AMN), mRNA
      gi|13569914|ref|NM030943.1|[13569914]
    • 570: BC018361
      Homo sapiens, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM)
      and short cytoplasmic domain, (semaphorin) 4F, clone MGC:21849 IMAGE:4215248, mRNA, complete cds
      gi|17390842|gb|BC018361.1|BC018361[17390842]
    • 571: AF214006
      Homo sapiens TDC1 (TDC1) mRNA, complete cds
      gi|17221828|gb|AF214006.1|AF214006[17221828]
    • 572: NM021201
      Homo sapiens membrane-spanning 4-domains, subfamily A, member 7 (MS4A7), mRNA
      gi|11139298|ref|NM021201.1|[11139298]
    • 573: AF289028
      Homo sapiens transmembrane protein B7-H2 ICOS ligand mRNA, complete cds
      gi|9858866|gb|AF289028.1|AF289028[9858866]
    • 574: NM016941
      Homo sapiens delta-like 3 (Drosophila) (DLL3), mRNA
      gi|8393263|ref|NM016941.1|[8393263]
    • 575: NM014450
      Homo sapiens SHP2 interacting transmembrane adaptor (SIT), mRNA
      gi|7657576|ref|NM014450.1|[7657576]
    • 576: NM021259
      Homo sapiens transmembrane protein 8 (five membrane-spanning domains) (TMEM8),
      mRNA
      gi|10864068|ref|NM021259.1|[10864068]
    • 577: NM002959
      Homo sapiens sortilin 1 (SORT1), mRNA
      gi|17149833|ref|NM002959.3|[17149833]
    • 578: NM000675
      Homo sapiens adenosine A2a receptor (ADORA2A), mRNA
      gi|17136146|ref|NM000675.3|[17136146]
    • 579: BM128846
      if17e06.x1 Melton Normalized Human Islet 4 N4-HIS 1 Homo sapiens cDNA 3′ similar
      to SW:PF27_MOUSE P52875 TRANSMEMBRANE PROTEIN PFT27. [1];, mRNA sequence
      gi|17123398|gb|BM128846.1|BM128846[17123398]
    • 580: BM127423
      ie95b07.y1 Melton Normalized Human Islet 4 N4-HIS 1 Homo sapiens cDNA 5′ similar
      to TR:O60639 O60639 PUTATIVE TRANSMEMBRANE GTPASE;, mRNA sequence
      gi|17121975|gb|BM127423.1|BM127423[17121975]
    • 581: AY016020
      Gallus gallus alpha globin gene cluster, complete sequence
      gi|17104478|gb|AY016020.1|[17104478]
    • 582: M86631
      Homo sapiens (clone ST-18-5(9/16)) cystic fibrosis transmembrane conductance regulator (CFTR) gene, 3′ end intron 17B; complete exon 18; complete intron
      gi|180296|gb|M86631.1|HUMCFTR[180296]
    • 584: BC017476
      Homo sapiens, sema domain, immunoglobulin domain (Ig), transmembrane domain TM)
      and short cytoplasmic domain, (semaphorin) 4C, clone MGC:15189 IMAGE:3528227, mRNA, complete cds
      gi|17028345|gb|BC017476.1|BC017476[17028345]
    • 585: NM000420
      Homo sapiens Kell blood group (KEL), mRNA
      gi|17025233|ref|NM000420.2|[17025233]
    • 586: BM090614
      ig16b09.y1 Human Fetal Pancreas 1A Homo sapiens cDNA 5′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|17019580|gb|BM090614.1|BM090614[17019580]
    • 587: AF217288
      Homo sapiens protocadherin-S mRNA, complete cds, alternatively spliced
      gi|15054520|gb|AF217288.1|AF217288[15054520]
    • 588: AF206516
      Homo sapiens protocadherin-S mRNA, complete cds
      gi|15054518 gb|AF206516.1|AF206516[15054518]
    • 589: NM021153
      Homo sapiens cadherin 19, type 2 (CDH19), mRNA
      gi|16306535|ref|NM021153.2|[16306535]
    • 590: AY048509
      Homo sapiens pannexin 1 (PANX1) gene, partial cds
      gi|15808666|gb|AY048509.1|[15808666]
    • 591: NG000012
      Homo sapiens genomic protocadherin gamma cluster (PCDHG@) on chromosome 5
      gi|14861871|ref|NG000012.1|[14861871]
    • 592: AE006466
      Homo sapiens 16p13.3 sequence section 5 of 8
      gi|14336735|gb|AE006466.1|AE006466[14336735]
    • 593: AF376725
      Homo sapiens lung seven transmembrane receptor 1 (LUSTR1) mRNA, complete cds
      gi|14248996|gb|AF376725.1|AF376725[14248996]
    • 594: NM004776
      Homo sapiens UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
      (B4GALT5), mRNA
      gi|13929470|ref|NM004776.2|[13929470]
    • 595: NM030587
      Homo sapiens UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2
      (B4GALT2), transcript variant 1, mRNA
      gi|13929464|ref|NM030587.1|[13929464]
    • 596: NM003780
      Homo sapiens UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2
      (B4GALT2), transcript variant 2, mRNA
      gi|13929463|ref|NM003780.2|[13929463]
    • 597: NM002590
      Homo sapiens protocadherin 8 (PCDH8), transcript variant 1, mRNA
      gi|6631101|ref|NM002590.2|[6631101]
    • 598: L42572
      Homo sapiens transmembrane protein (p87/89) mRNA, complete cds
      gi|1160962|gb|L42572.1|HUMP8789R[1160962]
    • 599: AF106202
      Homo sapiens endothelial cell protein C receptor precursor (EPCR) gene, promoter
      region and complete cds
      gi|16950557|gb|AF106202.2|AF106202[16950557]
    • 600: NM033207
      Homo sapiens transmembrane protein HTMP10 (HTMP10), mRNA
      gi|16945967|ref|NM033207.2|[16945967]
    • 601: AF153440
      Mus musculus Nma (Nma) mRNA, complete cds
      gi|14328906|gb|AF153440.1|AF153440[14328906]
    • 604: NM005086
      Homo sapiens sarcospan (Kras oncogene-associated gene) (SSPN), mRNA
      gi|16933560|ref|NM005086.3|[16933560]
    • 605: NM018153
      Homo sapiens tumor endothelial marker 8 (TEM8), transcript variant 3, mRNA
      gi|16933552|ref|NM018153.2|[16933552]
    • 606: NM053034
      Homo sapiens tumor endothelial marker 8 (TEM8), transcript variant 2, mRNA
      gi|16933550|ref|NM053034.1|[16933550]
    • 607: NM032208
      Homo sapiens tumor endothelial marker 8 (TEM8), transcript variant 1, mRNA
      gi|14149903|ref|NM032208.1|[14149903]
    • 608: AV225853
      AV225853 RIKEN full-length enriched, 18 days pregnant, placenta and extra embryonic tissue Mus musculus cDNA clone 3830432D01 3′ similar to X69910
      H. sapiens p63 mRNA for transmembrane protein, mRNA sequence
      gi|6177168|dbj|AV225853.1|AV225853[6177168]
    • 609: AV222771
      AV222771 RIKEN full-length enriched, 18 days pregnant, placenta and extra embryonic tissue Mus musculus cDNA clone 3830404C12 3′ similar to X69910
      H. sapiens p63 mRNA for transmembrane protein, mRNA sequence
      gi|6171948|dbj|AV222771.1|AV222771[6171948]
    • 611: BC017058
      Homo sapiens, Similar to seven transmembrane domain orphan receptor, clone MGC:9442 IMAGE:3904719, mRNA, complete cds
      gi|16877618|gb|BC017058.1|BC017058[16877618]
    • 612: BM055437
      ie94h04.y1 Melton Normalized Human Islet 4 N4-HIS 1 Homo sapiens cDNA 5′ similar
      to SW:CFTR_HUMAN P13569 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR;, mRNA sequence
      gi|16813328|gb|BM055437.1|BM055437[16813328]
    • 614: AF328788
      Homo sapiens amnionless mRNA, complete cds
      gi|13507258|gb|AF328788.1|AF328788[13507258]
    • 615: NM052836
      Homo sapiens cadherin related 23 (CDH23), transcript variant 2, mRNA
      gi|16507963|ref|NM052836.1|[16507963]
    • 616: NM022124
      Homo sapiens cadherin related 23 (CDH23), transcript variant 1, mRNA
      gi|16507961|ref|NM022124.2|[16507961]
    • 617: NM004063
      Homo sapiens cadherin 17, LI cadherin (liver-intestine) (CDH17), mRNA
      gi|16507959|ref|NM004063.2|[16507959]
    • 618: NM004062
      Homo sapiens cadherin 16, KSP-cadherin (CDH16), mRNA
      gi|16507958|ref|NM004062.2|[16507958]
    • 619: NM004933
      Homo sapiens cadherin 15, M-cadherin (myotubule) (CDH15), mRNA
      gi|16507957|ref|NM004933.2|[16507957]
    • 620: NM001257
      Homo sapiens cadherin 13, H-cadherin (heart) (CDH13), mRNA
      gi|16507956|ref|NM001257.2|[16507956]
    • 621: BC009704
      Homo sapiens, transmembrane 4 superfamily member 9, clone MGC:9300 IMAGE:3895933, mRNA, complete cds
      gi|16307230|gb|BC009704.1|BC009704[16307230]
    • 622: BC001496
      Homo sapiens, transmembrane trafficking protein, clone MGC:1979
      IMAGE:2959718, mRNA, complete cds
      gi|16306639|gb|BC001496.1|BC001496[16306639]
    • 623: BC013577
      Homo sapiens, claudin 11 (oligodendrocyte transmembrane protein), clone MGC:9232
      IMAGE:3895040, mRNA, complete cds
      gi|15488893|gb|BC013577.1|BC013577[15488893]
    • 624: NM053002
      Homo sapiens no opposite paired repeat protein (NOPAR), mRNA
      gi|16506292|ref|NM053002.1|[16506292]
    • 625: NM052995
      Homo sapiens Usher syndrome 3A (USH3A), mRNA
      gi|16506280|ref|NM052995.1|[16506280]
    • 639: NM014879
      Homo sapiens G protein-coupled receptor 105 (GPR105), mRNA
      gi|7661847|ref|NM014879.1|[7661847]
    • 640: NM052891
      Homo sapiens peptidoglycan recognition protein-1-alpha precursor (PGLYRPIalpha),
      mRNA
      gi|16418404|ref|NM052891.1|[16418404]
    • 642: B1964203
      ie66b09.y1 Melton Normalized Human Islet 4 N4-HIS 1 Homo sapiens cDNA 5′ similar
      to TR:Q99989 Q99989 TRANSMEMBRANE CHLORIDE CONDUCTOR PROTEIN;, mRNA sequence
      gi|16338608|gb|BI964203.1|BI964203[16338608]
    • 643: B1963913
      ie66e08.x1 Melton Normalized Human Islet 4 N4-HIS 1 Homo sapiens cDNA 3′ similar
      to SW:PF27_MOUSE P52875 TRANSMEMBRANE PROTEIN PFT27. [1];, mRNA sequence
      gi|16338318|gb|BI963913.1|BI963913[16338318]
    • 644: AF293372
      Pan troglodytes sialic acid-binding lectin Siglec-L1 mRNA, complete cds
      gi|15824309|gb|AF293372.1|AF293372[15824309]
    • 645: BC009696
      Homo sapiens, interferon induced transmembrane protein 2 (1-8D), clone MGC:9196
      IMAGE:3876542, mRNA, complete cds
      gi|16307214|gb|BC009696.1|BC009696[16307214]
    • 646: NM031891
      Homo sapiens cadherin 20, type 2 (CDH20), mRNA
      gi|16306536|ref|NM031891.2|[16306536]
    • 647: NM004361
      Homo sapiens cadherin 7, type 2 (CDH7), transcript variant b, mRNA
      gi|16306488|ref|NM004361.2|[16306488]
    • 648: NM033646
      Homo sapiens cadherin 7, type 2 (CDH7), transcript variant a, mRNA
      gi|16306486|ref|NM033646.1|[16306486]
    • 649: AF319952
      Homo sapiens tweety-like protein 2 mRNA, complete cds
      gi|16303747|gb|AF319952.1|AF319952[16303747]
    • 651: NM005756
      Homo sapiens G protein-coupled receptor 64 (GPR64), mRNA
      gi|5031732|ref|NM005756.1|[5031732]
    • 652: AF416903
      Homo sapiens SH2 domain-containing phosphatase anchor protein 2c mRNA, complete
      cds, alternatively spliced
      gi|16033593|gb|AF416903.1|AF416903[16033593]
    • 653: AF416902
      Homo sapiens SH2 domain-containing phosphatase anchor protein 2b mRNA, complete
      cds, alternatively spliced
      gi|16033590|gb|AF416902.1|AF416902[16033590]
    • 654: AF416901
      Homo sapiens SH2 domain-containing phosphatase anchor protein 2a mRNA, complete
      cds, alternatively spliced
      gi|16033587|gb|AF416901.1|AF416901[16033587]
    • 655: AF264740
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*015 allele,
      exon 6 and partial cds
      gi|16032983|gb|AF264740.1|AF264738S3[16032983]
    • 656: AF264739
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*015 allele,
      exons 4 and 5
      gi|16032982|gb|AF264739.1|AF264738S2[16032982]
    • 657: AF264738
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*015 allele,
      exons 2 and 3
      gi|16032981|gb|AF264738.1|AF264738S1[16032981]
    • 658: AH011143
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*015 allele,
      partial cds
      gi|16032980|gb|AH011143.1|SEG_AF264738S[16032980]
    • 659: NM033467
      Homo sapiens membrane metallo-endopeptidase-like 2 (MMEL2), mRNA
      gi|15991812|ref|NM033467.1|[15991812]
    • 660: AF378755
      Homo sapiens tumor endothelial marker 5 precursor (TEM5) mRNA, complete cds
      gi|15987490|gb|AF378755.1|AF378755[15987490]
    • 661: NM016227
      Homo sapiens chromosome 1 open reading frame 9 (C1orf9), mRNA
      gi|7705321|ref|NM016227.1|[7705321]
    • 662: NM014283
      Homo sapiens chromosome 1 open reading frame 9 (C1orf9), mRNA
      gi|7656939|ref|NM014283.1|[7656939]
    • 663: NM018475
      Homo sapiens TPA regulated locus (TPARL), mRNA
      gi|8923860|ref|NM018475.1|[8923860]
    • 664: D83783
      Human mRNA for KIAA0192 gene, partial cds
      gi|1663693|dbj|D83783.1D83783[1663693]
    • 665: D79997
      Human mRNA for KIAA0175 gene, complete cds
      gi|1136409|dbj|D79997.1|D79997[1136409]
    • 666: D13626
      Human mRNA for KIAA0001 gene, complete cds
      gi|285994|dbj|D13626.1|HUMRSC338[285994]
    • 679: B1793175
      ie48h08.y1 Melton Normalized Human Islet 4 N4-HIS 1 Homo sapiens cDNA 5′ similar
      to SW:NMB_HUMAN Q14956 PUTATIVE TRANSMEMBRANE PROTEIN NMB PRECURSOR.;, mRNA sequence
      gi|15820900|gb|BI793175.1|BI793175[15820900]
    • 680: U40271
      Homo sapiens transmembrane receptor precursor (PTK7) mRNA, complete cds
      gi|15808058|gb|U40271.2|HSU40271[15808058]
    • 681: BC014554
      Homo sapiens, calponin like transmembrane domain protein, clone IMAGE:3837453,
      mRNA
      gi|15778950|gb|BC014554.1|BC014554[15778950]
    • 682: NM018916
      Homo sapiens protocadherin gamma subfamily A, 3 (PCDHGA3), transcript variant 1,
      mRNA
      gi|14589879|ref|NM018916.3|[14589879]
    • 683: NM032407
      Homo sapiens protocadherin gamma subfamily C, 5 (PCDHGC5), transcript variant 2,
      mRNA
      gi|14277684|ref|NM032407.1|[14277684]
    • 684: NM018929
      Homo sapiens protocadherin gamma subfamily C, 5 (PCDHGC5), transcript variant 1,
      mRNA
      gi|14277683|ref|NM018929.2|[14277683]
    • 685: NM032406
      Homo sapiens protocadherin gamma subfamily C, 4 (PCDHGC4), transcript variant 2,
      mRNA
      gi|14277681|ref|NM032406.1|[14277681]
    • 686: NM018928
      Homo sapiens protocadherin gamma subfamily C, 4 (PCDHGC4), transcript variant 1,
      mRNA
      gi|14277680|ref|NM018928.2|[14277680]
    • 687: NM032101
      Homo sapiens protocadherin gamma subfamily B, 7 (PCDHGB7), transcript variant 2,
      mRNA
      gi|14270507|ref|NM032101.1|[14270507]
    • 688: NM018927
      Homo sapiens protocadherin gamma subfamily B, 7 (PCDHGB7), transcript variant 1,
      gi|14270506|ref|NM018927.2|[14270506]
    • 689: NM032099
      Homo sapiens protocadherin gamma subfamily B, 5 (PCDHGB5), transcript variant 2,
      mRNA
      gi|14270504|ref|NM032099.1|[14270504]
    • 690: NM018925
      Homo sapiens protocadherin gamma subfamily B, 5 (PCDHGB5), transcript variant 1,
      mRNA
      gi|14270503|ref|NM018925.2|[14270503]
    • 691: NM032100
      Homo sapiens protocadherin gamma subfamily B, 6 (PCDHGB6), transcript variant 2,
      mRNA
      gi|14270501|ref|NM032100.2|[14270501]
    • 692: NM018926
      Homo sapiens protocadherin gamma subfamily B, 6 (PCDHGB6), transcript variant 1,
      mRNA
      gi|14270500|ref|NM018926.2|[14270500]
    • 693: NM032097
      Homo sapiens protocadherin gamma subfamily B, 3 (PCDHGB3), transcript variant 2,
      mRNA
      gi|14270495|ref|NM032097.1|[14270495]
    • 694: NM018924
      Homo sapiens protocadherin gamma subfamily B, 3 (PCDHGB3), transcript variant 1,
      mRNA
      gi|14270494|ref|NM018924.2|[14270494]
    • 695: NM032096
      Homo sapiens protocadherin gamma subfamily B, 2 (PCDHGB2), transcript variant 2,
      mRNA
      gi|14270492|ref|NM032096.1|[14270492]
    • 696: NM018923
      Homo sapiens protocadherin gamma subfamily B, 2 (PCDHGB2), transcript variant 1,
      mRNA
      gi|14270491|ref|NM018923.2|[14270491]
    • 697: NM032095
      Homo sapiens protocadherin gamma subfamily B, 1 (PCDHGB1), transcript variant 2,
      mRNA
      gi|14270489|ref|NM032095.1|[14270489]
    • 698: NM018922
      Homo sapiens protocadherin gamma subfamily B, 1 (PCDHGB1), transcript variant 1,
      mRNA
      gi|14270488|ref|NM018922.2|[14270488]
    • 699: NM032089
      Homo sapiens protocadherin gamma subfamily A, 9 (PCDHGA9), transcript variant 2,
      mRNA
      gi|14270486|ref|NM032089.1|[14270486]
    • 700: NM018921
      Homo sapiens protocadherin gamma subfamily A, 9 (PCDHGA9), transcript variant 1,
      mRNA
      gi|14270485|ref|NM018921.2|[14270485]
    • 701: NM032088
      Homo sapiens protocadherin gamma subfamily A, 8 (PCDHGA8), transcript variant 1,
      mRNA
      gi|14270483|ref|NM032088.1|[14270483]
    • 702: NM014004
      Homo sapiens protocadherin gamma subfamily A, 8 (PCDHGA8), transcript variant 2,
      mRNA
      gi|14270482|ref|NM014004.2|[14270482]
    • 703: NM032087
      Homo sapiens protocadherin gamma subfamily A, 7 (PCDHGA7), transcript variant 2,
      mRNA
      gi|14196476|ref|NM032087.1|[14196476]
    • 704: NM018920
      Homo sapiens protocadherin gamma subfamily A, 7 (PCDHGA7), transcript variant 1,
      mRNA
      gi|14196475|ref|NM018920.2|[14196475]
    • 705: NM032086
      Homo sapiens protocadherin gamma subfamily A, 6 (PCDHGA6), transcript variant 2,
      mRNA
      gi|14196473|ref|NM032086.1|[14196473]
    • 706: NM018919
      Homo sapiens protocadherin gamma subfamily A, 6 (PCDHGA6), transcript variant 1,
      mRNA
      gi|14196472|ref|NM018919.2|[14196472]
    • 707: NM032054
      Homo sapiens protocadherin gamma subfamily A, 5 (PCDHGA5), transcript variant 2,
      mRNA
      gi|14196470|ref|NM032054.1|[14196470]
    • 708: NM018918
      Homo sapiens protocadherin gamma subfamily A, 5 (PCDHGA5), transcript variant 1,
      mRNA
      gi|14196469|ref|NM018918.2|[14196469]
    • 709: NM032053
      Homo sapiens protocadherin gamma subfamily A, 4 (PCDHGA4), transcript variant 2,
      mRNA
      gi|14196467|ref|NM032053.1|[14196467]
    • 710: NM018917
      Homo sapiens protocadherin gamma subfamily A, 4 (PCDHGA4), transcript variant 1,
      mRNA
      gi|14196466|ref|NM018917.2|[14196466]
    • 711: NM032011
      Homo sapiens protocadherin gamma subfamily A, 3 (PCDHGA3), transcript variant 2,
      mRNA
      gi|14196464|ref|NM032011.1|[14196464]
    • 712: NM032009
      Homo sapiens protocadherin gamma subfamily A, 2 (PCDHGA2), transcript variant 2,
      mRNA
      gi|14196461|ref|NM032009.1|[14196461]
    • 713: NM018915
      Homo sapiens protocadherin gamma subfamily A, 2 (PCDHGA2), transcript variant 1,
      mRNA
      gi|14196460|ref|NM018915.2|[14196460]
    • 714: NM031993
      Homo sapiens protocadherin gamma subfamily A, 1 (PCDHGA1), transcript variant 2,
      mRNA
      gi|14196458|ref|NM031993.1|[14196458]
    • 715: NM032092
      Homo sapiens protocadherin gamma subfamily A, 11 (PCDHGA11), transcript variant
      3, mRNA
      gi|14196454|ref|NM032092.1|[14196454]
    • 716: NM018912
      Homo sapiens protocadherin gamma subfamily A, 1 (PCDHGA1), transcript variant mRNA
      gi|14196453|ref|NM018912.2|[14196453]
    • 717: NM032091
      Homo sapiens protocadherin gamma subfamily A, 11 (PCDHGA11), transcript variant
      2, mRNA
      gi|14196450|ref|NM032091.1|[14196450]
    • 718: NM018914
      Homo sapiens protocadherin gamma subfamily A, 11 (PCDHGA11), transcript variant
      1, mRNA
      gi|14196449|ref|NM018914.2|[14196449]
    • 719: NM032090
      Homo sapiens protocadherin gamma subfamily A, 10 (PCDHGA10), transcript variant
      2, mRNA
      gi|14196447|ref|NM032090.1|[14196447]
    • 720: NM018913
      Homo sapiens protocadherin gamma subfamily A, 10 (PCDHGA10), transcript variant
      1, mRNA
      gi|14196446|ref|NM018913.2|[14196446]
    • 721: NM031411
      Homo sapiens protocadherin alpha 1 (PCDHA1), transcript variant 3, mRNA
      gi|14165401|ref|NM031411.1|[14165401]
    • 722: NM031849
      Homo sapiens protocadherin alpha 6 (PCDHA6), transcript variant 3, mRNA
      gi|14165393|ref|NM031849.1|[14165393]
    • 723: NM031860
      Homo sapiens protocadherin alpha 10 (PCDHA10), transcript variant 3, mRNA
      gi|14165382|ref|NM031860.1|[14165382]
    • 724: NM031442
      Homo sapiens brain cell membrane protein 1 (BCMP1), mRNA
      gi|13899272|ref|NM031442.1|[13899272]
    • 725: NM007000
      Homo sapiens uroplakin 1A (UPK1A), mRNA
      gi|5902147|ref|NM007000.1|[5902147]
    • 726: NM003332
      Homo sapiens TYRO protein tyrosine kinase binding protein (TYROBP), mRNA
      gi|4507754|ref|NM003332.1|[4507754]
    • 727: AF264747
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*00901 allele,
      exon 6 and partial cds
      gi|14279228|gb|AF264747.1|AF264744S3[14279228]
    • 728: AF264746
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*00901 allele,
      exons 4 and 5
      gi|14279227|gb|AF264746.1|AF264744S2[14279227]
    • 729: AF264744
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*00901 allele,
      exons 2 and 3
      gi|14279226|gb|AF264744.1|AF264744S1[14279226]
    • 730: AH010821
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*00901 allele,
      partial cds
      gi|14279225|gb|AH010821.1|SEG_AF264744S[14279225]
    • 731: AF264743
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*048 allele,
      exon 6 and partial cds
      gi|14279223|gb|AF264743.1|AF264741S3[14279223]
    • 732: AF264742
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*048 allele,
      exons 4 and 5
      gi|14279222|gb|AF264742.1|AF264741S2[14279222]
    • 733: AF264741
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*048 allele,
      exons 2 and 3
      gi|14279221|gb|AF264741.1|AF264741S1[14279221]
    • 734: AH010820
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*048 allele,
      partial cds
      gi|14279220|gb|AH010820.1|SEG_AF264741S[14279220]
    • 735: AF264737
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*017 allele,
      exon 6 and partial cds
      gi|14279218|gb|AF264737.1|AF264735S3[14279218]
    • 736: AF264736
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*017 allele,
      exons 4 and 5
      gi|14279217|gb|AF264736.1|AF264735S2[14279217]
    • 737: AF264735
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*017 allele,
      exons 2 and 3
      gi|14279216|gb|AF264735.1|AF264735S1[14279216]
    • 738: AH010819
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*017 allele,
      partial cds
      gi|14279215|gb|AH010819.1|SEG_AF264735S[14279215]
    • 739: AF336080
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*019 allele,
      exon 6 and partial cds
      gi|13469855|gb|AF336080.1|AF336079S2[13469855]
    • 740: AF336079
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*019 allele,
      exons 2 through 5
      gi|13469854|gb|AF336079.1|AF336079S1[13469854]
    • 741: AH010587
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*019 allele,
      partial cds
      gi|13469853|gb|AH010587.1|SEG_AF336079S[13469853]
    • 742: AF336086
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*001 allele,
      exon 6 and partial cds
      gi|13445651|gb|AF336086.1|AF336085S2[13445651]
    • 743: AF336085
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*001 allele,
      exons 2 through 5
      gi|13445650 gb|AF336085.1|AF336085S1[13445650]
    • 744: AH010572
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*001 allele,
      partial cds
      gi|13445649|gb|AH010572.1|SEG_AF336085S[13445649]
    • 745: AF336084
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*002 allele,
      exon 6 and partial cds
      gi|13445647|gb|AF336084.1|AF336083S2[13445647]
    • 746: AF336083
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*002 allele,
      exons 2 through 5
      gi|13445646|gb|AF336083.1|AF336083S1[13445646]
    • 747: AH010571
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*002 allele,
      partial cds
      gi|13445645|gb|AH010571.1|SEG_AF336083S[13445645]
    • 748: AF336070
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*009 allele,
      exon 6 and partial cds
      gi|13430213|gb|AF336070.1|AF336069S2[13430213]
    • 749: AF336069
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*009 allele,
      exons 2 through 5
      gi|3430212|gb|AF336069.1|AF336069S1[13430212]
    • 750: AH010569
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*009 allele,
      partial cds
      gi|13430211|gb|AH010569.1|SEG_AF336069S[13430211]
    • 751: AF336068
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*008 allele,
      exon 6
      gi|13430209|gb|AF336068.1|AF336067S2[13430209]
    • 752: AF336067
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*008 allele,
      exons 2 through 5 and partial cds
      gi|13430208|gb|AF336067.1|AF336067S1[13430208]
    • 753: AH010568
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*008 allele,
      partial cds
      gi|13430207|gb|AH010568.1|SEG_AF336067S[13430207]
    • 754: AF336082
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*012 allele,
      exon 6 and partial cds
      gi|13378046|gb|AF336082.1|AF336081S2[13378046]
    • 755: AF336081
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*012 allele,
      exons 2 through 5
      gi|13378045|gb|AF336081.1|AF336081S1[13378045]
    • 756: AH010562
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*012 allele,
      partial cds
      gi|13378044|gb|AH010562.1|SEG_AF336081S[13378044]
    • 757: AF336078
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*018 allele,
      exon 6 and partial cds
      gi|13378042|gb|AF336078.1|AF336077S2[13378042]
    • 758: AF336077
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*018 allele,
      exons 2 through 5
      gi|13378041|gb|AF336077.1|AF336077S1[13378041]
    • 759: AH010561
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*018 allele,
      partial cds
      gi|13378040|gb|AH010561.1|SEG_AF336077S[13378040]
    • 760: AF336076
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*016 allele,
      exon 6 and partial cds
      gi|13378038|gb|AF336076.1|AF336075S2[13378038]
    • 761: AF336075
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*016 allele,
      exons 2 through 5
      gi|13378037|gb|AF336075.1|AF336075S1[13378037]
    • 762: AH010560
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*016 allele,
      partial cds
      gi|13378036|gb|AH010560.1|SEG_AF336075S[13378036]
    • 763: AF336074
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*011 allele,
      exon 6 and partial cds
      gi|13346205|gb|AF336074.1|AF336073S2[13346205]
    • 764: AF336073
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*011 allele,
      exons 2 through 5
      gi|13346204|gb|AF336073.1|AF336073S1[13346204]
    • 765: AH010546
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*011 allele,
      partial cds
      gi|13346203|gb|AH010546.1|SEG_AF336073S[13346203]
    • 766: AF336064
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*002 allele,
      exon 6 and partial cds
      gi|13346201|gb|AF336064.1|AF336063S2[13346201]
    • 767: AF336063
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*002 allele,
      exons 2 through 5
      gi|13346200|gb|AF336063.1|AF336063S1[13346200]
    • 768: AH010545
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*002 allele,
      partial cds
      gi|13346199|gb|AH010545.1|SEG_AF336063S[13346199]
    • 769: AF336072
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*010 allele,
      exon 6 and partial cds
      gi|13310419|gb|AF336072.1|AF336071S2[13310419]
    • 770: AF336071
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*010 allele,
      exons 2 through 5
      gi|13310418|gb|AF336071.1|AF336071S1[13310418]
    • 771: AH010532
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*010 allele,
      partial cds
      gi|13310417|gb|AH010532.1|SEG_AF336071S[13310417]
    • 772: AF336066
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*006 allele,
      exon 6 and partial cds
      gi|13274608|gb|AF336066.1|AF336065S2[13274608]
    • 773: AF336065
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*006 allele,
      exons 2 through 5
      gi|13274607|gb|AF336065.1|AF336065S1[13274607]
    • 774: AH010526
      Homo sapiens MHC class I chain-related protein A (MICA) gene, MICA*006 allele,
      partial cds
      gi|13274606|gb|AH010526.1|SEG_AF336065S[13274606]
    • 775: NM022059
      Homo sapiens chemokine (C-X-C motif) ligand 16 (CXCL16), mRNA
      gi|11545764|ref|NM022059.1|[11545764]
    • 776: NM000024
      Homo sapiens adrenergic, beta-2-, receptor, surface (ADRB2), mRNA
      gi|15718673|ref|NM000024.3|[15718673]
    • 777: AF257472
      Homo sapiens transmembrane protein MT75 mRNA, complete cds
      gi|15718477|gb|AF257472.1|AF257472[15718477]
    • 778: AJ301609
      Homo sapiens partial mRNA for GluR6 kainate receptor (GRIK2 gene), exons 10, and 13
      gi|15485589|emb|AJ301609.1|HSA301609[15485589]
    • 779: AJ301608
      Homo sapiens partial mRNA for GluR6 kainate receptor (GRIK2 gene), exons 11, and 14
      gi|15485587|emb|AJ301608.1|HSA301608[15485587]
    • 780: B1713761
      ie03f09.y1 HR85 islet Homo sapiens cDNA 5′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|15689456|gb|BI713761.1|BI713761[15689456]
    • 781: B1713497
      ie03f09.x1 HR85 islet Homo sapiens cDNA 3′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|15689192|gb|BI713497.1|BI713497[15689192]
    • 782: B1712829
      ie09g03.y1 HR85 islet Homo sapiens cDNA 5′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|15688524|gb|BI712829.1|BI712829[15688524]
    • 783: B1712748
      ie08g08.y1 HR85 islet Homo sapiens cDNA 5′ similar to SW:TM21_RAT Q63584 TRANSMEMBRANE PROTEIN TMP21 PRECURSOR;, mRNA sequence
      gi|15688524|gb|BI712829.1|BI712829[15688524]
    • 784: B1711750
      id97b10.y1 Human insulinoma Homo sapiens cDNA 5′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|15687445|gb|BI711750.1|BI711750[15687445]
    • 785: B1711468
      id97b10.x1 Human insulinoma Homo sapiens cDNA 3′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|15687163|gb|BI711468.1|BI711468[15687163]
    • 786: B1711211
      id93c12.x1 Human insulinoma Homo sapiens cDNA 3′ similar to TR:P97544 P97544 ER
      TRANSMEMBRANE PROTEIN.;, mRNA sequence
      gi|15686906|gb|BI711211.1|BI711211[15686906]
    • 787: B1710795
      id92a02.y1 Human insulinoma Homo sapiens cDNA 5′ similar to SW:NMB_HUMAN Q14956
      PUTATIVE TRANSMEMBRANE PROTEIN NMB PRECURSOR.;, mRNA sequence
      gi|15686490|gb|BI710795.1|BI710795[15686490]
    • 788: BC014500
      Homo sapiens, Similar to leucine zipper-EF-hand containing transmembrane protein
      1, clone MGC:23613 IMAGE:4860194, mRNA, complete cds
      gi|15680274|gb|BC014500.1|BC014500[15680274]
    • 789: BC014443
      Homo sapiens, Similar to transmembrane protein vezatin, clone IMAGE:4851150, mRNA
      gi|15680188|gb|BC014443.1|BC014443[15680188]
    • 790: BC014339
      Homo sapiens, Similar to transmembrane 4 superfamily member 1, clone MGC:23935
      IMAGE:3828466, mRNA, complete cds
      gi|15680043|gb|BC014339.1|BC014339[15680043]
    • 791: NM032405
      Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant D,
      mRNA
      gi|14602456|ref|NM032405.1|[14602456]
    • 792: NM032404
      Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant C,
      mRNA
      gi|14602454|ref|NM032404.1|[14602454]
    • 793: NM032401
      Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant B,
      mRNA
      gi|14602452|ref|NM032401.1|[14602452]
    • 794: NM024022
      Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant A,
      mRNA
      gi|13173470|ref|NM024022.1|[13173470]
    • 795: AF325418
      Ovis aries cystic fibrosis transmembrane conductance regulator (CFTR) gene, intron 21
      gi|15637182|gb|AF325418.1|F325416S08[15637182]
    • 796: AF325419
      Ovis aries cystic fibrosis transmembrane conductance regulator (CFTR) gene, intron 10
      gi|15637180|gb|AF325419.1|F325416S06[15637180]
    • 797: AH011064
      Ovis aries
      gi|15637174|gb|AH011064.1|SEG_F325416S[15637174]
    • 798: NM022570
      Homo sapiens C-type (calcium dependent, carbohydrate-recognition domain) lectin,
      superfamily member 12 (CLECSF12), mRNA
      gi|13384603|ref|NM022570.2|[13384603]
    • 799: AF360695
      Homo sapiens keratinocyte growth factor receptor 2 (FGFR2) gene, exons 3 through
      22 and complete cds, alternatively spliced
      gi|15620559|gb|AF360695.3|AF410480S2[15620559]
    • 800: AH010989
      Homo sapiens keratinocyte growth factor receptor 2 (FGFR2) gene, complete cds,
      alternatively spliced
      gi|15620558|gb|AH010989.3|SEG_AF410480S[15620558]
    • 801: AY035377
      Homo sapiens peptidoglycan recognition protein-1-beta precursor (PGLYRPIbeta) mRNA, complete cds
      gi|15590685|gb|AY035377.1|[15590685]
    • 802: AY035376
      Homo sapiens peptidoglycan recognition protein-1-alpha precursor (PGLYRPIalpha)
      mRNA, complete cds
      gi|15590683|gb|AY035376.1|[15590683]
    • 803: NM013317
      Homo sapiens lung type-I cell membrane-associated glycoprotein (T1A-2), transcript variant 1, mRNA
      gi|7019416|ref|NM013317.1|[7019416]
    • 804: AJ318099
      Homo sapiens mRNA for putative endoplasmic reticulum multispan transmembrane protein (RFT1 gene)
      gi|15558857|emb|AJ318099.1|HSA318099[15558857]
    • 807: NM021808
      Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9) (GALNT9), mRNA
      gi|11141878|ref|NM021808.1|[11141878]
    • 808: AF275150
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 20 and complete cds
      gi|9652146|gb|AF275150.1|F275131S20[9652146]
    • 809: AF275149
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 19
      gi|9652145|gb|AF275149.1|F275131S19[9652145]
    • 810: AF275148
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 18
      gi|9652144|gb|AF275148.1|F275131S18[9652144]
    • 811: AF275147
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 17
      gi|9652143|gb|AF275147.1|F275131S17[9652143]
    • 812: AF275146
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 16
      gi|9652142|gb|AF275146.1|F275131S16[9652142]
    • 813: AF275145
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 15
      gi|9652141|gb|AF275145.1|F275131S15[9652141]
    • 814: AF275144
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 14
      gi|9652140|gb|AF275144.1|F275131S14[9652140]
    • 815: AF275143
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 13
      gi|9652139|gb|AF275143.1|F275131S13[9652139]
    • 816: AF275142
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 12
      gi|9652138|gb|AF275142.1|F275131S12[9652138]
    • 817: AF275141
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 11
      gi|9652137|gb|AF275141.1|F275131S11[9652137]
    • 818: AF275140
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 10
      gi|9652136|gb|AF275140.1|F275131S10[9652136]
    • 819: AF275139
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 9
      gi|9652135|gb|AF275139.1|F275131S09[9652135]
    • 820: AF275138
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 8
      gi|9652134|gb|AF275138.1|F275131S08[9652134]
    • 821: AF275137
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 7
      gi|9652133|gb|AF275137.1|F275131S07[9652133]
    • 822: AF275136
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 6
      gi|9652132|gb|AF275136.1|F275131S06[9652132]
    • 823: AF275135
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 5
      gi|9652131|gb|AF275135.1|F275131S05[9652131]
    • 824: AF275134
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 4
      gi|9652130|gb|AF275134.1F275131S04[9652130]
    • 825: AF275133
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 3
      gi|9652129|gb|AF275133.1F275131S03[9652129]
    • 826: AF275132
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 2
      gi|9652128|gb|AF275132.1|F275131S02[9652128]
    • 827: AF275131
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, exon 1
      gi|9652127|gb|AF275131.1|F275131S01[9652127]
    • 828: AH009676
      Homo sapiens transmembrane-type protein tyrosine phosphatase H (PTPRH) gene, complete cds
      gi|9652126|gb|AH009676.1|SEG_F275131S[9652126]
    • 829: NM017417
      Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8) (GALNT8), mRNA
      gi|8393411|ref|NM017417.1|[8393411]
    • 830: NM033346
      Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2), transcript variant 2, mRNA
      gi|15451917|ref|NM033346.1|[15451917]
    • 831: NM001204
      Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2), transcript variant 1, mRNA
      gi|15451915|ref|NM001204.3|[15451915]
    • 832: NM003933
      Homo sapiens BAI1-associated protein 3 (BAIAP3), mRNA
      gi|15451913|ref|NM003933.3|[15451913]
    • 833: NM014256
      Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3), mRNA
      gi|15451894|ref|NM014256.2|[15451894]-834: NM033274
      Homo sapiens a disintegrin and metalloproteinase domain 19 (meltrin beta) (ADAM19), transcript variant 2, mRNA
      gi|15451843|ref|NM033274.1|[15451843]
    • 835: NM023038
      Homo sapiens a disintegrin and metalloproteinase domain 19 (meltrin beta) (ADAM19), transcript variant 1, mRNA
      gi|15451841|ref|NM023038.2|[15451841]
    • 836: NM030765
      Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4), mRNA
      gi|13540526|ref|NM030765.1|[13540526]
    • 837: AB048207
      Homo sapiens mRNA for TIGA1, complete cds
      gi|15425668|dbj|AB048207.1|AB048207[15425668]
    • 838: NM006005
      Homo sapiens Wolfram syndrome 1 (wolframin) (WFS1), mRNA
      gi|13376995|ref|NM006005.2|[13376995]
    • 839: NM015722
      Homo sapiens calcyon; D1 dopamine receptor-interacting protein (CALCYON),
      gi|9257200|ref|NM015722.2|[9257200]
    • 840: AY038990
      Homo sapiens ER-localized type I transmembrane adaptor precursor (CAPER) mRNA,
      complete cds
      gi|15418959|gb|AY038990.1|[15418959]
    • 841: BB226825
      BB226825 RIKEN full-length enriched, adult male aorta and vein Mus musculus cDNA
      clone A530098L04 3′ similar to AF169676 Homo sapiens leucine-rich repeat transmembrane protein FLRT2 (FLRT2) mRNA, mRNA sequence
      gi|15410201|dbj|BB226825.2|BB226825[15410201]
    • 843: AF059274
      Homo sapiens neuroglycan C mRNA, complete cds
      gi|3820499|gb|AF059274.1|AF059274[3820499]
    • 844: BC013152
      Homo sapiens, Similar to transmembrane protein 5, clone MGC:17085 IMAGE:3919181, mRNA, complete cds
      gi|15341928|gb|BC013152.1|BC013152[15341928]
    • 845: AH011005
      Homo sapiens
      gi|15341629|gb|AH011005.1|SEG_L11671S[15341629]
    • 846: AF406650
      Homo sapiens putative gap junction protein pannexin 3 (PANX3) mRNA, complete cds
      gi|1534153|gb|AF406650.1|AF406650[15341531]
    • 847: L11671
      Homo sapiens transmembrane glycoprotein (CD53) gene, exon 1
      gi|291896|gb|L11671.1|L11671S1[291896]
    • 848: L11670
      Homo sapiens transmembrane glycoprotein (CD53) gene, exons 2 through 8
      gi|180145|gb|L11670.1|L11671S2[180145]
    • 849: B1468287
      id87a04.y1 Human insulinoma Homo sapiens cDNA 5′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|15284396|gb|BI468287.1|BI468287[15284396]
    • 850: B1468286
      id87a04.x1 Human insulinoma Homo sapiens cDNA 3′ similar to TR:Q9Y287 Q9Y287 TRANSMEMBRANE PROTEIN BRI.;, mRNA sequence
      gi|15284395|gb|BI468286.1|BI468286[15284395]

Claims (82)

1. A method of modulating an immune response in an animal comprising the step of administering to said animal a composition comprising
an antigen bearing target and further comprising a multifunctional molecule which comprises
a first amino acid sequence which can bind to a carbohydrate and a second amino acid sequence comprising a ligand for a cell surface polypeptide, wherein said ligand is chosen from the group: a ligand for a cytokine receptor, a ligand for CD40, a ligand for an adhesion molecule, a ligand for a defensin receptor, a ligand for a heat shock protein receptor, a ligand for a T cell costimulatory molecule, a ligand for a counterreceptor for a T cell costimulatory molecule.
2. The method of claim 1, wherein said animal is a mammal.
3. The method of claim 2, wherein said mammal is a human.
4. The method of claim 1, wherein said antigen bearing target comprises at least one of the following: a tumor antigen, a viral antigen, a bacterial antigen, a fungal antigen, a parasite antigen, a prion antigen, an antigen of an autoimmune disease.
5. The method of claim 1 wherein said antigen bearing target is a cell.
6. The method of claim 1, wherein said antigen bearing target is chosen from the group: a tumor cell, a virus, a bacterial cell, a fungal cell, a cell of a parasite, a prion, a mammalian cell, an insect cell, a polypeptide free of other cell-derived material.
7. The method of claim 5, wherein said antigen bearing target is pathogenic.
8. The method of claim 7, wherein said antigen bearing target is attenuated.
9. The method of claim 1, wherein said antigen bearing target is a cell which is substantially unable to divide.
10. The method of claim 1, wherein said multifunctional molecule is a fusion polypeptide.
11. The method of claim 10, wherein said first amino acid sequence is N-terminal to said second amino acid sequence.
12. The method of claim 10, wherein said first amino acid sequence is C-terminal to said second amino acid sequence.
13. The method of claim 5, wherein said multifunctional molecule is exogenous to said cell.
14. The method of claim 5, wherein said multifunctional molecule is endogenous to said cell and is encoded by a nucleic acid sequence comprised by the cell.
15. The method of claim 1, wherein said first amino acid sequence can bind to a sialic acid on a glycoprotein.
16. The method of claim 15, wherein said sialic acid comprises at least one of the following carbohydrate structures: N-acetylneuraminic acid, alpha-NeuNAc-[2->6]-Gal, alpha-NeuNAc-[2->6]-GalNAc, alpha-NeuNAc-[2->3]-Gal.
17. The method of claim 1, wherein said first amino acid sequence comprises a carbohydrate-binding domain of a naturally occuring lectin.
18. The method of claim 1, wherein said first amino acid sequence comprises at least about 10 contiguous amino acids of a hemagglutinin.
19. The method of claim 18, wherein said hemagglutinin is an influenza virus hemagglutinin.
20. The method of claim 19, wherein said contiguous amino acids of an influenza hemagglutinin are contiguous amino acids of an influenza hemagglutinin HA1 domain.
21. The method of claim 19, wherein said influenza virus is an influenza A virus.
22. The method of claim 21, wherein said influenza virus is of a subtype that infects humans.
23. The method of claim 21, wherein said influenza virus is of an H1 subtype.
24. The method of claim 23, wherein said influenza virus is from the strain A/PR/8/34.
25. The method of claim 24, wherein said influenza virus is of an H2 or H3 subtype.
26. The method of claim 19, wherein said influenza virus is of a subtype that does not infect humans.
27. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a mammalian cell surface polypeptide.
28. The method of claim 27, wherein said ligand for a cell surface polypeptide is a ligand for a mouse cell surface polypeptide.
29. The method of claim 27, wherein said ligand for a cell surface polypeptide is a ligand for a human cell surface polypeptide.
30. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a cell surface polypeptide of a leukocyte.
31. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a cell surface polypeptide of an antigen presenting cell.
32. The method of claim 31, wherein said ligand for a cell surface polypeptide is a ligand for a cell surface polypeptide of a professional antigen presenting cell.
33. The method of claim 30, wherein said ligand for a cell surface polypeptide is a ligand for a cell surface polypeptide of a dendritic cell.
34. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a mouse GM-CSF receptor.
35. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises at least about five contiguous amino acids of a mouse GM-CSF.
36. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises a mouse GM-CSF.
37. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a human GM-CSF receptor.
38. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises at least about five contiguous amino acids of a human GM-CSF.
39. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises a human GM-CSF.
40. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for an interleukin.
41. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for a mouse interleukin.
42. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for a human interleukin.
43. The method of claim 40, wherein said interleukin is chosen from the group: IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25.
44. The method of claim 40, wherein said ligand for a cell surface polypeptide comprises at least about 5 contiguous amino acids of an interleukin.
45. The method of claim 44, wherein said interleukin is chosen from the group: IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25.
46. The method of claim 40, wherein said ligand for a cell surface polypeptide comprises an interleukin.
47. The method of claim 46, wherein said interleukin is chosen from the group: IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25.
48. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for a chemokine.
49. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for a mouse chemokine.
50. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for a human chemokine.
51. The method of claim 48, wherein said chemokine is a C-C cytokine.
52. The method of claim 48, wherein said chemokine is a C-X-C cytokine.
53. The method of claim 48, wherein said cell surface polypeptide is chosen from the group: CXCR-1, CXCR-2, CXCR-3, CXCR-4, CCR-1, CCR-2, CCR-3, CCR-4, CCR-5, CCR-6, CCR-7, CCR-8.
54. The method of claim 48, wherein said chemokine is chosen from the group: 9E3, AMCF, beta-thromboglobulin, ENA-78, eotaxin, eotaxin-2, IP-10, KC, LIX, mig, MGSA, mob-1, NAP-2, NAP-3, NAP-4, PBSF, MGSA, mouse KC, MIP-2, MIP-1 alpha, NAP-2, ENA-78, GCP-2, ACT-2, C10, CCF18, DC-CK1, ELC, Exodus, FIC, GDCF, GDCF-2, HC-21, HCC-1, 1-309, JE, LAG-1, MARC, MCAF, MCP-1, MCP-2, MCP-3, MCP-4, MCP-5, MRP-2, RANTES SDF, TARC, ATAC, Ltn, SCM-1, neurotactin.
55. The method of claim 48, wherein said ligand for a cell surface polypeptide comprises at least about 5 contiguous amino acids of a chemokine.
56. The method of claim 55 wherein said chemokine is chosen from the group: 9E3, AMCF, beta-thromboglobulin, ENA-78, eotaxin, eotaxin-2, IP-10, KC, LIX, mig, MGSA, mob-1, NAP-2, NAP-3, NAP4, PBSF, MGSA, mouse KC, MIP-2, MIP-1 alpha, NAP-2, ENA-78, GCP-2, ACT-2, C10, CCF18, DC-CK1, ELC, Exodus, FIC, GDCF, GDCF-2, HC-21, HCC-1, 1-309, JE, LAG-1, MARC, MCAF, MCP-1, MCP-2, MCP-3, MCP-4, MCP-5, MRP-2, RANTES SDF, TARC, ATAC, Ltn, SCM-1, neurotactin.
57. The method of claim 48, wherein said ligand for a cell surface polypeptide comprises a chemokine.
58. The method of claim 57, wherein said chemokine is chosen from the group: 9E3, AMCF, beta-thromboglobulin, ENA-78, eotaxin, eotaxin-2, IP-10, KC, LIX, mig, MGSA, mob-1, NAP-2, NAP-3, NAP-4, PBSF, MGSA, mouse KC, MIP-2, MIP-1 alpha, NAP-2, ENA-78, GCP-2, ACT-2, C10, CCF18, DC-CK1, ELC, Exodus, FIC, GDCF, GDCF-2, HC-21, HCC-1, I-309, JE, LAG-1, MARC, MCAF, MCP-1, MCP-2, MCP-3, MCP-4, MCP-5, MRP-2, RANTES SDF, TARC, ATAC, Ltn, SCM-1, neurotactin.
59. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for an interferon.
60. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for a mouse interferon.
61. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a receptor for a human interferon.
62. The method of claim 59, wherein said interferon is chosen from the group: an interferon-alpha, an interferon-beta, an interferon gamma.
63. The method of claim 59, wherein said ligand for a cell surface polypeptide comprises at least about 5 contiguous amino acids of an interferon.
64. The method of claim 63, wherein said interferon is chosen from the group: an interferon-alpha, an interferon-beta, an interferon gamma.
65. The method of claim 59, wherein said ligand for a cell surface polypeptide comprises an interferon.
66. The method of claim 65, wherein said interferon is chosen from the group: an interferon-alpha, an interferon-beta, an interferon gamma.
67. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a mouse TNF-alpha receptor.
68. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises at least about five contiguous amino acids of a mouse TNF-alpha.
69. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises a mouse TNF-alpha.
70. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a human TNF-alpha receptor.
71. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises at least about five contiguous amino acids of a human TNF-alpha.
72. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises a human TNF-alpha.
73. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a mouse flt-3 receptor.
74. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises at least about five contiguous amino acids of a mouse flt-3.
75. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises a mouse flt-3.
76. The method of claim 1, wherein said ligand for a cell surface polypeptide is a ligand for a human flt-3 receptor.
77. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises at least about five contiguous amino acids of a human flt-3.
78. The method of claim 1, wherein said ligand for a cell surface polypeptide comprises a human flt-3.
79. The method of claim 10, wherein said fusion polypeptide further comprises a linker interposed between said first and second amino acid sequences.
80. The method of claim 79, wherein said linker has the formula (GlyxSer)n, wherein n is an integer between 1 and 15, and x is an integer between 1 and 10.
81. The method of claim 1, wherein said composition comprises said multifunctional molecule bound to a carbohydrate on said antigen bearing target.
82. The method of claim 1, in which at least some of said multifunctional molecule is not bound to said antigen bearing target.
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