US20050118073A1 - Devices and methods for holding microfluidic devices - Google Patents
Devices and methods for holding microfluidic devices Download PDFInfo
- Publication number
- US20050118073A1 US20050118073A1 US10/997,714 US99771404A US2005118073A1 US 20050118073 A1 US20050118073 A1 US 20050118073A1 US 99771404 A US99771404 A US 99771404A US 2005118073 A1 US2005118073 A1 US 2005118073A1
- Authority
- US
- United States
- Prior art keywords
- carrier
- microfluidic device
- housing
- accumulator
- valves
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00801—Means to assemble
- B01J2219/0081—Plurality of modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/10—Means to control humidity and/or other gases
- B01L2300/105—Means to control humidity and/or other gases using desiccants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0605—Valves, specific forms thereof check valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1004—Apparatus with means for measuring, testing, or sensing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1024—Apparatus for crystallization from liquid or supercritical state
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1024—Apparatus for crystallization from liquid or supercritical state
- Y10T117/1032—Seed pulling
- Y10T117/1064—Seed pulling including a fully-sealed or vacuum-maintained crystallization chamber [e.g., ampoule]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Definitions
- Microfluidic based protein crystallization devices and methods have been described in co-pending U.S. patent application Ser. No. 10/117,978 filed on Apr. 5, 2002, by Hansen, et al., which is herein incorporated by reference in its entirety for all purposes and the specific purpose of teaching microfluidic based protein crystallization devices and methods. Hansen described a carrier for holding the microfluidic devices described by Hansen in which a microfluidic device was placed onto a bottom plate and retained by a top plate.
- the invention provides, in one aspect, for a carrier for holding a microfluidic device comprising: a housing, the housing defining a chamber therein and having a receiving portion for receiving the microfluidic device; a connection block for retaining the microfluidic device, wherein the connection block is attachable to the microfluidic device through one or more prongs, and the microfluidic device, when retained by the connection block, is insertable into the receiving portion of the housing.
- the one or more prongs be two or more prongs, having at least one of the one or more prongs is a tube, having the receiver has at least one slot for guiding and retaining the microfluidic device when inserted into the receiving portion, having the receiver further comprises one or more pipette supports for guiding a pipette tip into the microfluidic device when inserted into the receiving portion, including one or more accumulators for providing fluid under pressure to the microfluidic device when inserted into the receiving portion, preferably where at least one accumulator further comprises a check valve, having the housing comprises a housing base and a housing cover, preferably where an accumulator is attached to the housing, and preferably where the housing cover and the housing base are sealed together by a gasket, including a humidity control material within the housing for providing humidity control, preferably where the humidity control material is selected from the group consisting of a sponge, a gel matrix, a desiccant, and a woven material, having the housing is preferably be made from
- FIG. 1 depicts a carrier described in the prior art.
- FIG. 2 depicts a perspective view of a preferred embodiment of the invention.
- the invention provides for devices, and methods for using such devices, for holding and manipulating microfluidic devices, in particular, multilayer elastomeric microfluidic devices wherein at least one deflectable membrane acts as a valve to interrupt or separate fluid within a microfluidic channel having a cross-sectional dimension of about 500 micrometers.
- Exemplary microfluidic devices have been described by Hansen, supra, which are used to screen for conditions which cause protein crystals to form from protein solutions by free-interface diffusion (FID).
- the devices of Hansen are loaded with a protein solution and a crystallization agent, typically in the form of a reagent solution, wherein each solution enters into individual chambers interconnected by a channel having a valve therein.
- Containment valves are then used to keep each of the solutions in their respective chamber as the valve located in the channel separating the chambers is opened to initiate diffusion between the chambers.
- the valves are actuated by changes in fluid pressure, for example either hydraulically or pneumatically. Therefore, a means for changing fluid pressure to each of the valve is helpful.
- FIG. 2 depicts a perspective view of a preferred embodiment.
- the carrier in FIG. 2 which preferably has about a three inch square footprint and is preferably about one inch in height, is preferably made from a polymer, preferably acrylic. Other materials may be used depending on the nature of the experiments to be performed using the carrier, and the solvents that the carrier may be exposed to during use.
- a carrier could be made from polypropylene to provide resistance to certain solvents such as acetone.
- carrier 1 comprises housing or main block 2 , a carrier lid or cover, not shown, which is used to close of the main block to form a chamber within carrier 1 .
- Microfluidic device 3 which may be a microfluidic device or chip used to grow protein crystals, is held by connection block 4 through pins 5 and 6 , which are preferably tubes in communication with flexible tubes 7 and 8 , which in turn are connected to a source of controlled fluid pressure used to actuate valves within the microfluidic device.
- Microfluidic device 3 while attached to connection block 4 , is inserted into main block 2 into a receiving portion 9 , which may include at least one slot for retaining microfluidic device 3 while inserted within main block 2 .
- microfluidic device 3 will be situated such that sample and reagent inlets 12 are within positioning guides 11 which are used to help a user to position a pipette tip into the microfluidic device for loading samples and reagents.
- Hydration control area 13 may further contain a source for hydration such as a sponge, a gel package, or a woven material such as a piece of cloth or a cotton ball/pad.
- connection block 4 In use, a user would insert pins 5 and 6 of connection block 4 into microfluidic device 3 , preferably in to ports located on the microfluidic device for communicating with valves therein. The microfluidic device would then be inserted into main block 2 to the extent that connection block 4 would contact, preferably mate, with receiving portion 9 of main block 2 . Samples and regents could then be loaded into the microfluidic device before the attachment of a carrier lid or cover, not shown, to main block 2 . Guides 10 and 11 would be used to help guide a pipette tip into the inlet port of the microfluidic device.
- At least one valve within the microfluidic device be activated so as to separate one or more fluid volumes contained within the microfluidic device.
- the user would then place carrier cover or lid, not shown, onto main block 2 to form a chamber housing the microfluidic device.
- a hydration control device such as a sponge or pad may also be placed within the chamber in region 13 , prior to attaching the cover.
- the sponge may be hydrated with water, buffer, a crystallization reagent, or a solvent.
- a desiccating material may added to remove moisture from the microfluidic device.
- an accumulator may be added to the carrier to provide a source of controlled fluid pressure.
- an accumulator chamber may be affixed to the main block or the lid of the carrier, the accumulator chamber being in fluid communication with the connection block, and, therefore, with the microfluidic device.
- the advantage of having an “on-board” source of controlled fluid pressure is that the microfluidic device, if actuated by changes in fluid pressure, can be kept in an actuated state independent of an external source of fluid pressure, thus liberating the microfluidic device and carrier from an umbilical cord attached to that external source of fluid pressure.
- the accumulator may further include a check valve for retaining fluid pressure within the accumulator.
- the accumulator may further include a gas pressurization inlet port, a liquid addition port, and a pressurized fluid outlet for communicating fluid pressure to the connection block.
- Appendix A “TopazTM Growth Chip, User Guide”, Fluidigm Corporation, So. San Francisco, Calif., 94080, which is s part of U.S. Provisional Application No. 60/525,245 (the application to which this application claims priority), filed Nov. 26, 2003, is expressly incorporated herein by reference in its entirety for all purposes. Appendix A is thus is to be construed as part of the present specification for all purposes.
Abstract
Description
- This application claims the benefit of U.S. Provisional Application No. 60/525,245, filed Nov. 26, 2003, which is incorporated herein by reference in its entirety for all purposes.
- Microfluidic based protein crystallization devices and methods have been described in co-pending U.S. patent application Ser. No. 10/117,978 filed on Apr. 5, 2002, by Hansen, et al., which is herein incorporated by reference in its entirety for all purposes and the specific purpose of teaching microfluidic based protein crystallization devices and methods. Hansen described a carrier for holding the microfluidic devices described by Hansen in which a microfluidic device was placed onto a bottom plate and retained by a top plate.
- The invention provides, in one aspect, for a carrier for holding a microfluidic device comprising: a housing, the housing defining a chamber therein and having a receiving portion for receiving the microfluidic device; a connection block for retaining the microfluidic device, wherein the connection block is attachable to the microfluidic device through one or more prongs, and the microfluidic device, when retained by the connection block, is insertable into the receiving portion of the housing. Other embodiments include having the one or more prongs be two or more prongs, having at least one of the one or more prongs is a tube, having the receiver has at least one slot for guiding and retaining the microfluidic device when inserted into the receiving portion, having the receiver further comprises one or more pipette supports for guiding a pipette tip into the microfluidic device when inserted into the receiving portion, including one or more accumulators for providing fluid under pressure to the microfluidic device when inserted into the receiving portion, preferably where at least one accumulator further comprises a check valve, having the housing comprises a housing base and a housing cover, preferably where an accumulator is attached to the housing, and preferably where the housing cover and the housing base are sealed together by a gasket, including a humidity control material within the housing for providing humidity control, preferably where the humidity control material is selected from the group consisting of a sponge, a gel matrix, a desiccant, and a woven material, having the housing is preferably be made from a polymer, more preferably where the polymer is either polycarbonate or acrylic or polystyrene, preferably where the accumulator is in fluid communication with the connection block through one or more accumulator-connection block tubes, wherein the accumulator-connection block tubes are preferably flexible, having a first tube of the one or more tubes is in communication with the microfluidic device for controlling one or more first valves, preferably wherein a second tube of the one or more tubes is in communication with the microfluidic device for controlling one or more second valves, for example, but not limited to, wherein the first valves are interface valves and/or wherein the second valves are containment valves.
-
FIG. 1 depicts a carrier described in the prior art. -
FIG. 2 depicts a perspective view of a preferred embodiment of the invention. - The invention provides for devices, and methods for using such devices, for holding and manipulating microfluidic devices, in particular, multilayer elastomeric microfluidic devices wherein at least one deflectable membrane acts as a valve to interrupt or separate fluid within a microfluidic channel having a cross-sectional dimension of about 500 micrometers. Exemplary microfluidic devices have been described by Hansen, supra, which are used to screen for conditions which cause protein crystals to form from protein solutions by free-interface diffusion (FID). In use, the devices of Hansen are loaded with a protein solution and a crystallization agent, typically in the form of a reagent solution, wherein each solution enters into individual chambers interconnected by a channel having a valve therein. Containment valves are then used to keep each of the solutions in their respective chamber as the valve located in the channel separating the chambers is opened to initiate diffusion between the chambers. In preferred devices of Hansen, the valves are actuated by changes in fluid pressure, for example either hydraulically or pneumatically. Therefore, a means for changing fluid pressure to each of the valve is helpful.
- The invention provides, in one aspect, for a carrier that provides access to controlled fluid pressure.
FIG. 2 depicts a perspective view of a preferred embodiment. The carrier inFIG. 2 , which preferably has about a three inch square footprint and is preferably about one inch in height, is preferably made from a polymer, preferably acrylic. Other materials may be used depending on the nature of the experiments to be performed using the carrier, and the solvents that the carrier may be exposed to during use. For example, a carrier could be made from polypropylene to provide resistance to certain solvents such as acetone. - In
FIG. 2 , carrier 1 comprises housing or main block 2, a carrier lid or cover, not shown, which is used to close of the main block to form a chamber within carrier 1.Microfluidic device 3, which may be a microfluidic device or chip used to grow protein crystals, is held by connection block 4 through pins 5 and 6, which are preferably tubes in communication with flexible tubes 7 and 8, which in turn are connected to a source of controlled fluid pressure used to actuate valves within the microfluidic device.Microfluidic device 3, while attached to connection block 4, is inserted into main block 2 into a receiving portion 9, which may include at least one slot for retainingmicrofluidic device 3 while inserted within main block 2. Once fully inserted,microfluidic device 3 will be situated such that sample andreagent inlets 12 are withinpositioning guides 11 which are used to help a user to position a pipette tip into the microfluidic device for loading samples and reagents.Hydration control area 13 may further contain a source for hydration such as a sponge, a gel package, or a woven material such as a piece of cloth or a cotton ball/pad. - In use, a user would insert pins 5 and 6 of connection block 4 into
microfluidic device 3, preferably in to ports located on the microfluidic device for communicating with valves therein. The microfluidic device would then be inserted into main block 2 to the extent that connection block 4 would contact, preferably mate, with receiving portion 9 of main block 2. Samples and regents could then be loaded into the microfluidic device before the attachment of a carrier lid or cover, not shown, to main block 2.Guides region 13, prior to attaching the cover. The sponge may be hydrated with water, buffer, a crystallization reagent, or a solvent. Alternatively, a desiccating material may added to remove moisture from the microfluidic device. - In preferred embodiments, an accumulator may be added to the carrier to provide a source of controlled fluid pressure. For example, an accumulator chamber may be affixed to the main block or the lid of the carrier, the accumulator chamber being in fluid communication with the connection block, and, therefore, with the microfluidic device. The advantage of having an “on-board” source of controlled fluid pressure is that the microfluidic device, if actuated by changes in fluid pressure, can be kept in an actuated state independent of an external source of fluid pressure, thus liberating the microfluidic device and carrier from an umbilical cord attached to that external source of fluid pressure. In preferred embodiments, the accumulator may further include a check valve for retaining fluid pressure within the accumulator. The accumulator may further include a gas pressurization inlet port, a liquid addition port, and a pressurized fluid outlet for communicating fluid pressure to the connection block.
- While the present invention has been described herein with reference to particular embodiments thereof, a latitude of modification, various changes and substitutions are intended in the foregoing disclosure, and it will be appreciated that in some instances some features of the invention will be employed without a corresponding use of other features without departing from the scope of the invention as set forth. Therefore, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope and spirit of the present invention. It is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments and equivalents falling within the scope of the claims.
- The entire contents of Appendix A, “Topaz™ Growth Chip, User Guide”, Fluidigm Corporation, So. San Francisco, Calif., 94080, which is s part of U.S. Provisional Application No. 60/525,245 (the application to which this application claims priority), filed Nov. 26, 2003, is expressly incorporated herein by reference in its entirety for all purposes. Appendix A is thus is to be construed as part of the present specification for all purposes.
Claims (20)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/997,714 US20050118073A1 (en) | 2003-11-26 | 2004-11-24 | Devices and methods for holding microfluidic devices |
US12/573,623 US8282896B2 (en) | 2003-11-26 | 2009-10-05 | Devices and methods for holding microfluidic devices |
US12/761,917 US9623413B2 (en) | 2000-04-05 | 2010-04-16 | Integrated chip carriers with thermocycler interfaces and methods of using the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52524503P | 2003-11-26 | 2003-11-26 | |
US10/997,714 US20050118073A1 (en) | 2003-11-26 | 2004-11-24 | Devices and methods for holding microfluidic devices |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/573,623 Continuation US8282896B2 (en) | 2003-11-26 | 2009-10-05 | Devices and methods for holding microfluidic devices |
Publications (1)
Publication Number | Publication Date |
---|---|
US20050118073A1 true US20050118073A1 (en) | 2005-06-02 |
Family
ID=34623220
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/997,714 Abandoned US20050118073A1 (en) | 2000-04-05 | 2004-11-24 | Devices and methods for holding microfluidic devices |
US12/573,623 Expired - Fee Related US8282896B2 (en) | 2003-11-26 | 2009-10-05 | Devices and methods for holding microfluidic devices |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/573,623 Expired - Fee Related US8282896B2 (en) | 2003-11-26 | 2009-10-05 | Devices and methods for holding microfluidic devices |
Country Status (1)
Country | Link |
---|---|
US (2) | US20050118073A1 (en) |
Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020192716A1 (en) * | 1999-03-19 | 2002-12-19 | Volker Schellenberger | Multi-through hole testing plate for high throughput screening |
US20060094108A1 (en) * | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
US20070003448A1 (en) * | 2004-03-12 | 2007-01-04 | Kanigan Tanya S | Nanoliter array loading |
WO2007016931A1 (en) * | 2005-07-25 | 2007-02-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Chip-holder for a micro-fluidic chip |
WO2007115378A1 (en) * | 2006-04-11 | 2007-10-18 | Minifab (Australia) Pty Ltd | Microfluidic package housing |
US20080038839A1 (en) * | 2004-01-26 | 2008-02-14 | Vincent Linder | Fluid Delivery System And Method |
US20080273918A1 (en) * | 2007-05-04 | 2008-11-06 | Claros Diagnostics, Inc. | Fluidic connectors and microfluidic systems |
US20090136963A1 (en) * | 2007-06-21 | 2009-05-28 | Gen-Probe Incorporated | Methods of concentrating an analyte |
US20090302190A1 (en) * | 2006-10-25 | 2009-12-10 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Chip holder, fluidic system and chip holder system |
US7682565B2 (en) * | 2002-12-20 | 2010-03-23 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
US20100196207A1 (en) * | 2009-02-02 | 2010-08-05 | David Steinmiller | Structures for controlling light interaction with microfluidic devices |
US20110120562A1 (en) * | 2009-11-24 | 2011-05-26 | Claros Diagnostics, Inc. | Fluid mixing and delivery in microfluidic systems |
US8016260B2 (en) | 2007-07-19 | 2011-09-13 | Formulatrix, Inc. | Metering assembly and method of dispensing fluid |
USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
US8029745B2 (en) | 1998-01-12 | 2011-10-04 | Massachusetts Institute Of Technology | Systems for filling a sample array by droplet dragging |
US8100293B2 (en) | 2009-01-23 | 2012-01-24 | Formulatrix, Inc. | Microfluidic dispensing assembly |
US8222049B2 (en) | 2008-04-25 | 2012-07-17 | Opko Diagnostics, Llc | Flow control in microfluidic systems |
US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
US8389272B2 (en) | 2004-01-26 | 2013-03-05 | President And Fellows Of Harvard College | Fluid delivery system and method |
US8580569B2 (en) | 2010-04-16 | 2013-11-12 | Opko Diagnostics, Llc | Feedback control in microfluidic systems |
US8591829B2 (en) | 2008-12-18 | 2013-11-26 | Opko Diagnostics, Llc | Reagent storage in microfluidic systems and related articles and methods |
US8906618B2 (en) | 2000-02-18 | 2014-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
US9205468B2 (en) | 2009-11-30 | 2015-12-08 | Fluidigm Corporation | Microfluidic device regeneration |
US9255866B2 (en) | 2013-03-13 | 2016-02-09 | Opko Diagnostics, Llc | Mixing of fluids in fluidic systems |
CN106257243A (en) * | 2015-06-16 | 2016-12-28 | 亚诺法生技股份有限公司 | The clamping carrier of micro runner device |
US20170056880A1 (en) * | 2015-08-26 | 2017-03-02 | EMULATE, Inc. | Fluid connections using guide mechanisms |
USD804682S1 (en) | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
US10279345B2 (en) | 2014-12-12 | 2019-05-07 | Opko Diagnostics, Llc | Fluidic systems comprising an incubation channel, including fluidic systems formed by molding |
US10672503B2 (en) | 2012-03-05 | 2020-06-02 | Opko Diagnostics, Llc | Methods and apparatuses for conducting analyses |
US10852310B2 (en) | 2015-12-11 | 2020-12-01 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US8052792B2 (en) * | 2001-04-06 | 2011-11-08 | California Institute Of Technology | Microfluidic protein crystallography techniques |
US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
WO2001001025A2 (en) * | 1999-06-28 | 2001-01-04 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
EP1334347A1 (en) | 2000-09-15 | 2003-08-13 | California Institute Of Technology | Microfabricated crossflow devices and methods |
EP1343973B2 (en) | 2000-11-16 | 2020-09-16 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
JP4355210B2 (en) | 2001-11-30 | 2009-10-28 | フルイディグム コーポレイション | Microfluidic device and method of using microfluidic device |
WO2003085379A2 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US8220494B2 (en) * | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
EP2213615A3 (en) | 2002-09-25 | 2012-02-29 | California Institute of Technology | Microfluidic Large Scale Integration |
JP5695287B2 (en) | 2002-10-02 | 2015-04-01 | カリフォルニア インスティテュート オブ テクノロジー | Nucleic acid analysis of microfluids |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7695683B2 (en) | 2003-05-20 | 2010-04-13 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
EP1754257B1 (en) | 2004-06-07 | 2013-12-25 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US20080264863A1 (en) | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
JP2008522795A (en) * | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | Microfluidic device with chemical reaction circuit |
US7883669B2 (en) | 2005-04-20 | 2011-02-08 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
US20070054293A1 (en) * | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
EP1938101A2 (en) * | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Microfluidic assay devices and methods |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US8828661B2 (en) * | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
US8055034B2 (en) | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
WO2008067552A2 (en) * | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
EP2125219B1 (en) | 2007-01-19 | 2016-08-10 | Fluidigm Corporation | High precision microfluidic devices and methods |
BRPI0816393A2 (en) * | 2007-09-07 | 2015-03-03 | Fluidigm Corp | METHOD FOR DETERMINING THE NUMBER OF COPIES REGARDING A TARGET POLINUCLEOTIDE SEQUENCE IN A GENOME OF AN INDIVIDUAL |
WO2009100449A1 (en) | 2008-02-08 | 2009-08-13 | Fluidigm Corporation | Dynamic array assay methods |
EP2280905B1 (en) | 2008-04-11 | 2016-07-06 | Fluidigm Corporation | Multilevel microfluidic systems and methods |
US9579830B2 (en) | 2008-07-25 | 2017-02-28 | Fluidigm Corporation | Method and system for manufacturing integrated fluidic chips |
US8617488B2 (en) | 2008-08-07 | 2013-12-31 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
US8058630B2 (en) * | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
US8551787B2 (en) * | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
SG169918A1 (en) | 2009-10-02 | 2011-04-29 | Fluidigm Corp | Microfluidic devices with removable cover and methods of fabrication and application |
WO2012054933A2 (en) | 2010-10-22 | 2012-04-26 | Fluidigm Corporation | Universal probe assay methods |
US9168531B2 (en) | 2011-03-24 | 2015-10-27 | Fluidigm Corporation | Method for thermal cycling of microfluidic samples |
CN103635594B (en) | 2011-05-09 | 2018-02-13 | 富鲁达公司 | Detection of nucleic acids based on probe |
US9644231B2 (en) | 2011-05-09 | 2017-05-09 | Fluidigm Corporation | Nucleic acid detection using probes |
JP2017518752A (en) * | 2014-06-12 | 2017-07-13 | ウエハージェン インコーポレイテッド | Single cell capture using a capture polymer membrane |
US9717644B2 (en) | 2014-12-22 | 2017-08-01 | John H. Shadduck | Wearable sensing and actuator systems, and methods of use |
GB201704769D0 (en) * | 2017-01-03 | 2017-05-10 | Illumina Inc | Flowcell cartridge with floating seal bracket |
Citations (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3570515A (en) * | 1969-06-19 | 1971-03-16 | Foxboro Co | Aminar stream cross-flow fluid diffusion logic gate |
US3747628A (en) * | 1971-02-17 | 1973-07-24 | Philips Corp | Fluidic function module for use in a system for constructing fluidic circuits |
US4046159A (en) * | 1974-10-08 | 1977-09-06 | Pegourie Jean Pierre | Pneumatic logic circuits and their integrated circuits |
US4119368A (en) * | 1975-12-25 | 1978-10-10 | Citizen Watch Co. Ltd. | Elastomer display device |
US4153855A (en) * | 1977-12-16 | 1979-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method of making a plate having a pattern of microchannels |
US4245673A (en) * | 1978-03-01 | 1981-01-20 | La Telemechanique Electrique | Pneumatic logic circuit |
US4434704A (en) * | 1980-04-14 | 1984-03-06 | Halliburton Company | Hydraulic digital stepper actuator |
US4898582A (en) * | 1988-08-09 | 1990-02-06 | Pharmetrix Corporation | Portable infusion device assembly |
US4992312A (en) * | 1989-03-13 | 1991-02-12 | Dow Corning Wright Corporation | Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby |
US5085562A (en) * | 1989-04-11 | 1992-02-04 | Westonbridge International Limited | Micropump having a constant output |
US5088515A (en) * | 1989-05-01 | 1992-02-18 | Kamen Dean L | Valve system with removable fluid interface |
US5096388A (en) * | 1990-03-22 | 1992-03-17 | The Charles Stark Draper Laboratory, Inc. | Microfabricated pump |
US5126115A (en) * | 1987-10-27 | 1992-06-30 | Fujitsu Limited | Process and apparatus for preparation of single crystal of biopolymer |
US5164558A (en) * | 1991-07-05 | 1992-11-17 | Massachusetts Institute Of Technology | Micromachined threshold pressure switch and method of manufacture |
US5171132A (en) * | 1989-12-27 | 1992-12-15 | Seiko Epson Corporation | Two-valve thin plate micropump |
US5224843A (en) * | 1989-06-14 | 1993-07-06 | Westonbridge International Ltd. | Two valve micropump with improved outlet |
US5259737A (en) * | 1990-07-02 | 1993-11-09 | Seiko Epson Corporation | Micropump with valve structure |
US5265327A (en) * | 1991-09-13 | 1993-11-30 | Faris Sadeg M | Microchannel plate technology |
US5290240A (en) * | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
US5336062A (en) * | 1990-02-27 | 1994-08-09 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Microminiaturized pump |
US5346372A (en) * | 1991-07-18 | 1994-09-13 | Aisin Seiki Kabushiki Kaisha | Fluid flow regulating device |
US5375979A (en) * | 1992-06-19 | 1994-12-27 | Robert Bosch Gmbh | Thermal micropump with values formed from silicon plates |
US5376252A (en) * | 1990-05-10 | 1994-12-27 | Pharmacia Biosensor Ab | Microfluidic structure and process for its manufacture |
US5400741A (en) * | 1993-05-21 | 1995-03-28 | Medical Foundation Of Buffalo, Inc. | Device for growing crystals |
US5423287A (en) * | 1992-11-25 | 1995-06-13 | Nissan Motor Company, Ltd. | Crystal growing cell |
US5529465A (en) * | 1991-09-11 | 1996-06-25 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Micro-miniaturized, electrostatically driven diaphragm micropump |
US5593130A (en) * | 1993-06-09 | 1997-01-14 | Pharmacia Biosensor Ab | Valve, especially for fluid handling bodies with microflowchannels |
US5642015A (en) * | 1993-07-14 | 1997-06-24 | The University Of British Columbia | Elastomeric micro electro mechanical systems |
US5659171A (en) * | 1993-09-22 | 1997-08-19 | Northrop Grumman Corporation | Micro-miniature diaphragm pump for the low pressure pumping of gases |
US5660370A (en) * | 1996-03-07 | 1997-08-26 | Integrated Fludics, Inc. | Valve with flexible sheet member and two port non-flexing backer member |
US5681024A (en) * | 1993-05-21 | 1997-10-28 | Fraunhofer-Gesellschaft zur Forderung der angerwanden Forschung e.V. | Microvalve |
US5705018A (en) * | 1995-12-13 | 1998-01-06 | Hartley; Frank T. | Micromachined peristaltic pump |
US5759010A (en) * | 1995-11-06 | 1998-06-02 | Jacobs; Merrit Nyles | Sealed cartridge to improve chemistry stability of test elements |
US5759014A (en) * | 1994-01-14 | 1998-06-02 | Westonbridge International Limited | Micropump |
US5775371A (en) * | 1995-03-08 | 1998-07-07 | Abbott Laboratories | Valve control |
US5788468A (en) * | 1994-11-03 | 1998-08-04 | Memstek Products, Llc | Microfabricated fluidic devices |
US5836750A (en) * | 1997-10-09 | 1998-11-17 | Honeywell Inc. | Electrostatically actuated mesopump having a plurality of elementary cells |
US5842787A (en) * | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US5875817A (en) * | 1995-08-17 | 1999-03-02 | Ortech Corporation | Digital gas metering system using tri-stable and bi-stable solenoids |
US5876187A (en) * | 1995-03-09 | 1999-03-02 | University Of Washington | Micropumps with fixed valves |
US5932799A (en) * | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US6043080A (en) * | 1995-06-29 | 2000-03-28 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US6123769A (en) * | 1995-03-01 | 2000-09-26 | Sumitomo Metal Industries, Ltd. | Crystallization control method for organic compound and crystallization control solid-state component employed therefor |
US6155282A (en) * | 1998-01-20 | 2000-12-05 | Triconex, Incorporated | Two out of three voting solenoid arrangement |
US6174365B1 (en) * | 1996-07-15 | 2001-01-16 | Sumitomo Metal Industries, Ltd. | Apparatus for crystal growth and crystal growth method employing the same |
US6296452B1 (en) * | 2000-04-28 | 2001-10-02 | Agilent Technologies, Inc. | Microfluidic pumping |
US6296673B1 (en) * | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
US20010027745A1 (en) * | 2000-03-31 | 2001-10-11 | Weigl Bernhard H. | Protein crystallization in microfluidic structures |
US6319476B1 (en) * | 1999-03-02 | 2001-11-20 | Perseptive Biosystems, Inc. | Microfluidic connector |
US6345502B1 (en) * | 1997-11-12 | 2002-02-12 | California Institute Of Technology | Micromachined parylene membrane valve and pump |
US20020037499A1 (en) * | 2000-06-05 | 2002-03-28 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
US20020192701A1 (en) * | 2001-03-09 | 2002-12-19 | Adey Nils B. | Laminated microarray interface device |
US20030061687A1 (en) * | 2000-06-27 | 2003-04-03 | California Institute Of Technology, A California Corporation | High throughput screening of crystallization materials |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3747626A (en) * | 1971-05-05 | 1973-07-24 | J Valentino | Combined check and relief valve |
US4153856A (en) * | 1977-05-16 | 1979-05-08 | Rca Corporation | Proximity focused element scale image display device |
US4581624A (en) | 1984-03-01 | 1986-04-08 | Allied Corporation | Microminiature semiconductor valve |
US5096368A (en) * | 1987-11-20 | 1992-03-17 | Butterfield Floyd S | Method for storing and transporting stacks of flexible sheets |
US5364742A (en) | 1992-09-21 | 1994-11-15 | International Business Machines Corporation | Micro-miniature structures and method of fabrication thereof |
DE4433894A1 (en) | 1994-09-22 | 1996-03-28 | Fraunhofer Ges Forschung | Method and device for controlling a micropump |
DE69531430T2 (en) | 1994-10-07 | 2004-07-01 | Bayer Corp. | relief valve |
US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
KR100207410B1 (en) | 1995-12-19 | 1999-07-15 | 전주범 | Fabrication method for lightpath modulation device |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
US5738799A (en) | 1996-09-12 | 1998-04-14 | Xerox Corporation | Method and materials for fabricating an ink-jet printhead |
US6221654B1 (en) * | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US5971355A (en) | 1996-11-27 | 1999-10-26 | Xerox Corporation | Microdevice valve structures to fluid control |
WO1999000655A2 (en) | 1997-06-27 | 1999-01-07 | Immunetics, Inc. | Rapid flow-through binding assay apparatus and method |
US6529612B1 (en) | 1997-07-16 | 2003-03-04 | Diversified Scientific, Inc. | Method for acquiring, storing and analyzing crystal images |
US6073482A (en) | 1997-07-21 | 2000-06-13 | Ysi Incorporated | Fluid flow module |
US6833242B2 (en) * | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
US6540895B1 (en) * | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US7214298B2 (en) * | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
WO1999052633A1 (en) | 1998-04-14 | 1999-10-21 | Ivd Systems | Test cartridge with a single inlet port |
AU4719399A (en) | 1998-06-26 | 2000-01-17 | University Of Washington | Crystallization media |
RU2143343C1 (en) | 1998-11-03 | 1999-12-27 | Самсунг Электроникс Ко., Лтд. | Microinjector and microinjector manufacture method |
US6958865B1 (en) * | 1998-11-12 | 2005-10-25 | California Institute Of Technology | Microlicensing particles and applications |
AU779792B2 (en) | 1999-04-06 | 2005-02-10 | Uab Research Foundation, The | Method for screening crystallization conditions in solution crystal growth |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US7144616B1 (en) * | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7459022B2 (en) * | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
WO2001001025A2 (en) * | 1999-06-28 | 2001-01-04 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
EP1206697A2 (en) | 1999-08-02 | 2002-05-22 | Emerald Biostructures Inc. | Method and system for creating a crystallization results database |
US7149509B2 (en) | 1999-12-06 | 2006-12-12 | Twenty Year Innovations, Inc. | Methods and apparatuses for programming user-defined information into electronic devices |
WO2001067369A2 (en) | 2000-03-03 | 2001-09-13 | California Institute Of Technology | Combinatorial array for nucleic acid analysis |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US6885982B2 (en) * | 2000-06-27 | 2005-04-26 | Fluidigm Corporation | Object oriented microfluidic design method and system |
AU2001273057A1 (en) * | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
US6301055B1 (en) * | 2000-08-16 | 2001-10-09 | California Institute Of Technology | Solid immersion lens structures and methods for producing solid immersion lens structures |
EP1334347A1 (en) | 2000-09-15 | 2003-08-13 | California Institute Of Technology | Microfabricated crossflow devices and methods |
US7678547B2 (en) * | 2000-10-03 | 2010-03-16 | California Institute Of Technology | Velocity independent analyte characterization |
EP1322936A2 (en) * | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Microfluidic devices and methods of use |
US7097809B2 (en) * | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
WO2002030486A2 (en) | 2000-10-13 | 2002-04-18 | Fluidigm Corporation | Microfluidic device based sample injection system for analytical devices |
US7232109B2 (en) * | 2000-11-06 | 2007-06-19 | California Institute Of Technology | Electrostatic valves for microfluidic devices |
AU2002248149A1 (en) * | 2000-11-16 | 2002-08-12 | Fluidigm Corporation | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
EP1343973B2 (en) | 2000-11-16 | 2020-09-16 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US6752922B2 (en) * | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
EP1385692B1 (en) * | 2001-04-06 | 2011-03-02 | Fluidigm Corporation | Polymer surface modification |
AU2002307152A1 (en) | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
US7075162B2 (en) | 2001-08-30 | 2006-07-11 | Fluidigm Corporation | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes |
US6705018B2 (en) * | 2001-10-01 | 2004-03-16 | Scott David Guhse | Modified chalk line end with retractable blade |
JP2005505441A (en) * | 2001-10-08 | 2005-02-24 | カリフォルニア インスティテュート オブ テクノロジー | Microfabricated lens, its manufacturing method and application |
US7192629B2 (en) * | 2001-10-11 | 2007-03-20 | California Institute Of Technology | Devices utilizing self-assembled gel and method of manufacture |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
WO2003085379A2 (en) * | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US7059348B2 (en) * | 2002-05-13 | 2006-06-13 | Fluidigm Corporation | Drug delivery system |
US20060086309A1 (en) * | 2002-06-24 | 2006-04-27 | Fluiding Corporation | Recirculating fluidic network and methods for using the same |
EP2213615A3 (en) * | 2002-09-25 | 2012-02-29 | California Institute of Technology | Microfluidic Large Scale Integration |
JP5695287B2 (en) * | 2002-10-02 | 2015-04-01 | カリフォルニア インスティテュート オブ テクノロジー | Nucleic acid analysis of microfluids |
GB0302302D0 (en) | 2003-01-31 | 2003-03-05 | Glaxo Group Ltd | Microfluidic apparatus and method |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7476363B2 (en) * | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
JP5419248B2 (en) * | 2003-04-03 | 2014-02-19 | フルイディグム コーポレイション | Microfluidic device and method of use thereof |
US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
EP1685282A2 (en) * | 2003-04-17 | 2006-08-02 | Fluidigm Corporation | Crystal growth devices and systems, and methods for using same |
US7695683B2 (en) * | 2003-05-20 | 2010-04-13 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
AU2004261655A1 (en) * | 2003-07-28 | 2005-02-10 | Fluidigm Corporation | Image processing method and system for microfluidic devices |
US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
US7042649B2 (en) * | 2003-08-11 | 2006-05-09 | California Institute Of Technology | Microfabricated rubber microscope using soft solid immersion lenses |
US20060172408A1 (en) * | 2003-12-01 | 2006-08-03 | Quake Steven R | Device for immobilizing chemical and biochemical species and methods of using same |
US7407799B2 (en) * | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
EP1754257B1 (en) | 2004-06-07 | 2013-12-25 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US20080264863A1 (en) | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
JP2008522795A (en) | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | Microfluidic device with chemical reaction circuit |
JP3111895U (en) * | 2005-04-15 | 2005-07-28 | 株式会社フジコー | Toner scraping material |
US7883669B2 (en) | 2005-04-20 | 2011-02-08 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
WO2007044091A2 (en) | 2005-06-02 | 2007-04-19 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
US20070054293A1 (en) * | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
EP1938101A2 (en) | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Microfluidic assay devices and methods |
US8206975B2 (en) * | 2005-10-28 | 2012-06-26 | California Institute Of Technology | Method and device for regulating fluid flow in microfluidic devices |
EP1987358A4 (en) * | 2006-01-26 | 2013-12-04 | California Inst Of Techn | Mechanically induced trapping of molecular interactions |
US20070248971A1 (en) * | 2006-01-26 | 2007-10-25 | California Institute Of Technology | Programming microfluidic devices with molecular information |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US8828661B2 (en) * | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
US8055034B2 (en) * | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
WO2008043046A2 (en) | 2006-10-04 | 2008-04-10 | Fluidigm Corporation | Microfluidic check valves |
WO2008067552A2 (en) * | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
EP2125219B1 (en) * | 2007-01-19 | 2016-08-10 | Fluidigm Corporation | High precision microfluidic devices and methods |
US7665361B2 (en) * | 2007-01-25 | 2010-02-23 | Freescale Semiconductor, Inc. | Method and apparatus for closed loop offset cancellation |
US7974380B2 (en) * | 2007-05-09 | 2011-07-05 | Fluidigm Corporation | Method and system for crystallization and X-ray diffraction screening |
BRPI0816393A2 (en) * | 2007-09-07 | 2015-03-03 | Fluidigm Corp | METHOD FOR DETERMINING THE NUMBER OF COPIES REGARDING A TARGET POLINUCLEOTIDE SEQUENCE IN A GENOME OF AN INDIVIDUAL |
WO2009100449A1 (en) | 2008-02-08 | 2009-08-13 | Fluidigm Corporation | Dynamic array assay methods |
US9487822B2 (en) * | 2008-03-19 | 2016-11-08 | Fluidigm Corporation | Method and apparatus for determining copy number variation using digital PCR |
US9579830B2 (en) | 2008-07-25 | 2017-02-28 | Fluidigm Corporation | Method and system for manufacturing integrated fluidic chips |
US8617488B2 (en) | 2008-08-07 | 2013-12-31 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
SG10201404682WA (en) | 2008-12-08 | 2014-10-30 | Fluidigm Corp | Programmable microfluidic digital array |
US8058630B2 (en) * | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
-
2004
- 2004-11-24 US US10/997,714 patent/US20050118073A1/en not_active Abandoned
-
2009
- 2009-10-05 US US12/573,623 patent/US8282896B2/en not_active Expired - Fee Related
Patent Citations (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3570515A (en) * | 1969-06-19 | 1971-03-16 | Foxboro Co | Aminar stream cross-flow fluid diffusion logic gate |
US3747628A (en) * | 1971-02-17 | 1973-07-24 | Philips Corp | Fluidic function module for use in a system for constructing fluidic circuits |
US4046159A (en) * | 1974-10-08 | 1977-09-06 | Pegourie Jean Pierre | Pneumatic logic circuits and their integrated circuits |
US4119368A (en) * | 1975-12-25 | 1978-10-10 | Citizen Watch Co. Ltd. | Elastomer display device |
US4153855A (en) * | 1977-12-16 | 1979-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method of making a plate having a pattern of microchannels |
US4245673A (en) * | 1978-03-01 | 1981-01-20 | La Telemechanique Electrique | Pneumatic logic circuit |
US4434704A (en) * | 1980-04-14 | 1984-03-06 | Halliburton Company | Hydraulic digital stepper actuator |
US5126115A (en) * | 1987-10-27 | 1992-06-30 | Fujitsu Limited | Process and apparatus for preparation of single crystal of biopolymer |
US4898582A (en) * | 1988-08-09 | 1990-02-06 | Pharmetrix Corporation | Portable infusion device assembly |
US4992312A (en) * | 1989-03-13 | 1991-02-12 | Dow Corning Wright Corporation | Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby |
US5085562A (en) * | 1989-04-11 | 1992-02-04 | Westonbridge International Limited | Micropump having a constant output |
US5088515A (en) * | 1989-05-01 | 1992-02-18 | Kamen Dean L | Valve system with removable fluid interface |
US5224843A (en) * | 1989-06-14 | 1993-07-06 | Westonbridge International Ltd. | Two valve micropump with improved outlet |
US5171132A (en) * | 1989-12-27 | 1992-12-15 | Seiko Epson Corporation | Two-valve thin plate micropump |
US5336062A (en) * | 1990-02-27 | 1994-08-09 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Microminiaturized pump |
US5096388A (en) * | 1990-03-22 | 1992-03-17 | The Charles Stark Draper Laboratory, Inc. | Microfabricated pump |
US5376252A (en) * | 1990-05-10 | 1994-12-27 | Pharmacia Biosensor Ab | Microfluidic structure and process for its manufacture |
US5259737A (en) * | 1990-07-02 | 1993-11-09 | Seiko Epson Corporation | Micropump with valve structure |
US5164558A (en) * | 1991-07-05 | 1992-11-17 | Massachusetts Institute Of Technology | Micromachined threshold pressure switch and method of manufacture |
US5346372A (en) * | 1991-07-18 | 1994-09-13 | Aisin Seiki Kabushiki Kaisha | Fluid flow regulating device |
US5529465A (en) * | 1991-09-11 | 1996-06-25 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Micro-miniaturized, electrostatically driven diaphragm micropump |
US5265327A (en) * | 1991-09-13 | 1993-11-30 | Faris Sadeg M | Microchannel plate technology |
US5375979A (en) * | 1992-06-19 | 1994-12-27 | Robert Bosch Gmbh | Thermal micropump with values formed from silicon plates |
US5423287A (en) * | 1992-11-25 | 1995-06-13 | Nissan Motor Company, Ltd. | Crystal growing cell |
US5290240A (en) * | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
US5400741A (en) * | 1993-05-21 | 1995-03-28 | Medical Foundation Of Buffalo, Inc. | Device for growing crystals |
US5681024A (en) * | 1993-05-21 | 1997-10-28 | Fraunhofer-Gesellschaft zur Forderung der angerwanden Forschung e.V. | Microvalve |
US5593130A (en) * | 1993-06-09 | 1997-01-14 | Pharmacia Biosensor Ab | Valve, especially for fluid handling bodies with microflowchannels |
US5642015A (en) * | 1993-07-14 | 1997-06-24 | The University Of British Columbia | Elastomeric micro electro mechanical systems |
US5659171A (en) * | 1993-09-22 | 1997-08-19 | Northrop Grumman Corporation | Micro-miniature diaphragm pump for the low pressure pumping of gases |
US5759014A (en) * | 1994-01-14 | 1998-06-02 | Westonbridge International Limited | Micropump |
US5788468A (en) * | 1994-11-03 | 1998-08-04 | Memstek Products, Llc | Microfabricated fluidic devices |
US6123769A (en) * | 1995-03-01 | 2000-09-26 | Sumitomo Metal Industries, Ltd. | Crystallization control method for organic compound and crystallization control solid-state component employed therefor |
US5775371A (en) * | 1995-03-08 | 1998-07-07 | Abbott Laboratories | Valve control |
US5876187A (en) * | 1995-03-09 | 1999-03-02 | University Of Washington | Micropumps with fixed valves |
US6043080A (en) * | 1995-06-29 | 2000-03-28 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5875817A (en) * | 1995-08-17 | 1999-03-02 | Ortech Corporation | Digital gas metering system using tri-stable and bi-stable solenoids |
US5759010A (en) * | 1995-11-06 | 1998-06-02 | Jacobs; Merrit Nyles | Sealed cartridge to improve chemistry stability of test elements |
US5705018A (en) * | 1995-12-13 | 1998-01-06 | Hartley; Frank T. | Micromachined peristaltic pump |
US6007309A (en) * | 1995-12-13 | 1999-12-28 | Hartley; Frank T. | Micromachined peristaltic pumps |
US5660370A (en) * | 1996-03-07 | 1997-08-26 | Integrated Fludics, Inc. | Valve with flexible sheet member and two port non-flexing backer member |
US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US6174365B1 (en) * | 1996-07-15 | 2001-01-16 | Sumitomo Metal Industries, Ltd. | Apparatus for crystal growth and crystal growth method employing the same |
US5932799A (en) * | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
US5836750A (en) * | 1997-10-09 | 1998-11-17 | Honeywell Inc. | Electrostatically actuated mesopump having a plurality of elementary cells |
US5842787A (en) * | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US6345502B1 (en) * | 1997-11-12 | 2002-02-12 | California Institute Of Technology | Micromachined parylene membrane valve and pump |
US6155282A (en) * | 1998-01-20 | 2000-12-05 | Triconex, Incorporated | Two out of three voting solenoid arrangement |
US6319476B1 (en) * | 1999-03-02 | 2001-11-20 | Perseptive Biosystems, Inc. | Microfluidic connector |
US6296673B1 (en) * | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
US20010027745A1 (en) * | 2000-03-31 | 2001-10-11 | Weigl Bernhard H. | Protein crystallization in microfluidic structures |
US6409832B2 (en) * | 2000-03-31 | 2002-06-25 | Micronics, Inc. | Protein crystallization in microfluidic structures |
US6296452B1 (en) * | 2000-04-28 | 2001-10-02 | Agilent Technologies, Inc. | Microfluidic pumping |
US20020037499A1 (en) * | 2000-06-05 | 2002-03-28 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
US6767706B2 (en) * | 2000-06-05 | 2004-07-27 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
US20030061687A1 (en) * | 2000-06-27 | 2003-04-03 | California Institute Of Technology, A California Corporation | High throughput screening of crystallization materials |
US20020192701A1 (en) * | 2001-03-09 | 2002-12-19 | Adey Nils B. | Laminated microarray interface device |
Cited By (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8029745B2 (en) | 1998-01-12 | 2011-10-04 | Massachusetts Institute Of Technology | Systems for filling a sample array by droplet dragging |
US10195579B2 (en) | 1999-03-19 | 2019-02-05 | Life Technologies Corporation | Multi-through hole testing plate for high throughput screening |
US7666360B2 (en) | 1999-03-19 | 2010-02-23 | Biotrove, Inc. | Multi-through hole testing plate for high throughput screening |
US20020192716A1 (en) * | 1999-03-19 | 2002-12-19 | Volker Schellenberger | Multi-through hole testing plate for high throughput screening |
US8906618B2 (en) | 2000-02-18 | 2014-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
US10378049B2 (en) | 2000-02-18 | 2019-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of microvolume liquid reactions |
US9518299B2 (en) | 2000-02-18 | 2016-12-13 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
US10227644B2 (en) | 2000-02-18 | 2019-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of microvolume liquid reactions |
US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
US8685340B2 (en) | 2002-08-23 | 2014-04-01 | Life Technologies Corporation | Microfluidic transfer pin |
US9428800B2 (en) | 2002-12-20 | 2016-08-30 | Life Technologies Corporation | Thermal cycling apparatus and method |
US20060094108A1 (en) * | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
US8697452B2 (en) | 2002-12-20 | 2014-04-15 | Life Technologies Corporation | Thermal cycling assay apparatus and method |
US7682565B2 (en) * | 2002-12-20 | 2010-03-23 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
US8030057B2 (en) | 2004-01-26 | 2011-10-04 | President And Fellows Of Harvard College | Fluid delivery system and method |
US9116148B2 (en) | 2004-01-26 | 2015-08-25 | President And Fellows Of Harvard College | Fluid delivery system and method |
US8389272B2 (en) | 2004-01-26 | 2013-03-05 | President And Fellows Of Harvard College | Fluid delivery system and method |
US20080038839A1 (en) * | 2004-01-26 | 2008-02-14 | Vincent Linder | Fluid Delivery System And Method |
US10048252B2 (en) | 2004-01-26 | 2018-08-14 | President And Fellows Of Harvard College | Fluid delivery system and method |
US8105554B2 (en) | 2004-03-12 | 2012-01-31 | Life Technologies Corporation | Nanoliter array loading |
US9266108B2 (en) | 2004-03-12 | 2016-02-23 | Life Technologies Corporation | Nanoliter array loading |
US8545772B2 (en) | 2004-03-12 | 2013-10-01 | Life Technologies Corporation | Nanoliter array loading |
US10065189B2 (en) | 2004-03-12 | 2018-09-04 | Life Technologies Corporation | Nanoliter array loading |
US20070003448A1 (en) * | 2004-03-12 | 2007-01-04 | Kanigan Tanya S | Nanoliter array loading |
US10974247B2 (en) | 2004-03-12 | 2021-04-13 | Life Technologies Corporation | Nanoliter array loading |
US8153059B2 (en) | 2005-07-25 | 2012-04-10 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Chip-holder for a micro-fluidic chip |
US20080299013A1 (en) * | 2005-07-25 | 2008-12-04 | Frakunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E. V. | Chip-Holder for a Micro-Fluidic Chip |
WO2007016931A1 (en) * | 2005-07-25 | 2007-02-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Chip-holder for a micro-fluidic chip |
WO2007115378A1 (en) * | 2006-04-11 | 2007-10-18 | Minifab (Australia) Pty Ltd | Microfluidic package housing |
US20090302190A1 (en) * | 2006-10-25 | 2009-12-10 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Chip holder, fluidic system and chip holder system |
US9075047B2 (en) | 2007-05-04 | 2015-07-07 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
US8802445B2 (en) | 2007-05-04 | 2014-08-12 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
US20080273918A1 (en) * | 2007-05-04 | 2008-11-06 | Claros Diagnostics, Inc. | Fluidic connectors and microfluidic systems |
US8475737B2 (en) | 2007-05-04 | 2013-07-02 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
US10775369B2 (en) | 2007-05-04 | 2020-09-15 | Opko Diagnostics, Llc | Fluidic systems for analyses |
US9234888B2 (en) | 2007-05-04 | 2016-01-12 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
US8409527B2 (en) | 2007-05-04 | 2013-04-02 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
US10408824B2 (en) | 2007-05-04 | 2019-09-10 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
US8202492B2 (en) | 2007-05-04 | 2012-06-19 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
US8765367B2 (en) | 2007-06-21 | 2014-07-01 | Gen-Probe Incorporated | Methods and instruments for processing a sample in a multi-chambered receptacle |
US20090136963A1 (en) * | 2007-06-21 | 2009-05-28 | Gen-Probe Incorporated | Methods of concentrating an analyte |
US20090142771A1 (en) * | 2007-06-21 | 2009-06-04 | Gen-Probe Incorporated | Methods and Instruments for Processing a Sample in a Multi-Chambered Receptacle |
US10744469B2 (en) * | 2007-06-21 | 2020-08-18 | Gen-Probe Incorporated | Multi-chambered receptacles |
US8828654B2 (en) | 2007-06-21 | 2014-09-09 | Gen-Probe Incorporated | Methods for manipulating liquid substances in multi-chambered receptacles |
US11235295B2 (en) | 2007-06-21 | 2022-02-01 | Gen-Probe Incorporated | System and method of using multi-chambered receptacles |
US10688458B2 (en) | 2007-06-21 | 2020-06-23 | Gen-Probe Incorporated | System and method of using multi-chambered receptacles |
US11235294B2 (en) | 2007-06-21 | 2022-02-01 | Gen-Probe Incorporated | System and method of using multi-chambered receptacles |
US20090137029A1 (en) * | 2007-06-21 | 2009-05-28 | Gen-Probe Incorporated | Multi-Chambered Receptacles |
US8735055B2 (en) | 2007-06-21 | 2014-05-27 | Gen-Probe Incorporated | Methods of concentrating an analyte |
US8016260B2 (en) | 2007-07-19 | 2011-09-13 | Formulatrix, Inc. | Metering assembly and method of dispensing fluid |
US8222049B2 (en) | 2008-04-25 | 2012-07-17 | Opko Diagnostics, Llc | Flow control in microfluidic systems |
US10159978B2 (en) | 2008-04-25 | 2018-12-25 | Opko Diagnostics, Llc | Flow control in microfluidic systems |
US9592505B2 (en) | 2008-04-25 | 2017-03-14 | Opko Diagnostics, Llc | Flow control in microfluidic systems |
US9849455B2 (en) | 2008-04-25 | 2017-12-26 | Opko Diagnostics, Llc | Flow control in microfluidic systems |
US10589265B2 (en) | 2008-12-18 | 2020-03-17 | Opko Diagnostics, Llc | Reagent storage in microfluidic systems and related articles and methods |
US8591829B2 (en) | 2008-12-18 | 2013-11-26 | Opko Diagnostics, Llc | Reagent storage in microfluidic systems and related articles and methods |
US9561506B2 (en) | 2008-12-18 | 2017-02-07 | Opko Diagnostics, Llc | Reagent storage in microfluidic systems and related articles and methods |
US9878324B2 (en) | 2008-12-18 | 2018-01-30 | Opko Diagnostics, Llc | Reagent storage in microfluidic systems and related articles and methods |
US8100293B2 (en) | 2009-01-23 | 2012-01-24 | Formulatrix, Inc. | Microfluidic dispensing assembly |
US8550298B2 (en) | 2009-01-23 | 2013-10-08 | Formulatrix, Inc. | Microfluidic dispensing assembly |
US20100196207A1 (en) * | 2009-02-02 | 2010-08-05 | David Steinmiller | Structures for controlling light interaction with microfluidic devices |
US9827564B2 (en) | 2009-02-02 | 2017-11-28 | Opko Diagnostics, Llc | Fluidic systems and methods for analyses |
US8480975B2 (en) | 2009-02-02 | 2013-07-09 | Opko Diagnostics, Llc | Structures for controlling light interaction with microfluidic devices |
US8221700B2 (en) | 2009-02-02 | 2012-07-17 | Opko Diagnostics, Llc | Structures for controlling light interaction with microfluidic devices |
US8802029B2 (en) | 2009-02-02 | 2014-08-12 | Opko Diagnostics, Llc | Structures for controlling light interaction with microfluidic devices |
US9827563B2 (en) | 2009-02-02 | 2017-11-28 | Opko Diagnostics, Llc | Fluidic systems and methods for analyses |
US9770715B2 (en) | 2009-02-02 | 2017-09-26 | Opko Diagnostics, Llc | Structures for controlling light interaction with microfluidic devices |
US9075051B2 (en) | 2009-11-24 | 2015-07-07 | Opko Diagnostics, Llc | Fluid mixing and delivery in microfluidic systems |
US9555408B2 (en) | 2009-11-24 | 2017-01-31 | Opko Diagnostics, Llc | Fluid mixing and delivery in microfluidic systems |
US20110120562A1 (en) * | 2009-11-24 | 2011-05-26 | Claros Diagnostics, Inc. | Fluid mixing and delivery in microfluidic systems |
US8567425B2 (en) | 2009-11-24 | 2013-10-29 | Opko Diagnostics, Llc | Fluid mixing and delivery in microfluidic systems |
US9861980B2 (en) | 2009-11-24 | 2018-01-09 | Opko Diagnostics, Llc | Fluid mixing and delivery in microfluidic systems |
US10953398B2 (en) | 2009-11-24 | 2021-03-23 | Opko Diagnostics, Llc | Fluid mixing and delivery in microfluidic systems |
US9731291B2 (en) | 2009-11-24 | 2017-08-15 | Opko Diagnostics, Llc | Fluid mixing and delivery in microfluidic systems |
US8915259B2 (en) | 2009-11-24 | 2014-12-23 | Opko Diagnostics, Llc | Fluid mixing and delivery in microfluidic systems |
US10413899B2 (en) | 2009-11-24 | 2019-09-17 | Opko Diagnostics, Llc | Fluid mixing and delivery in microfluidic systems |
US9205468B2 (en) | 2009-11-30 | 2015-12-08 | Fluidigm Corporation | Microfluidic device regeneration |
US8765062B2 (en) | 2010-04-16 | 2014-07-01 | Opko Diagnostics, Llc | Systems and devices for analysis of samples |
US9682376B2 (en) | 2010-04-16 | 2017-06-20 | Opko Diagnostics, Llc | Systems and devices for analysis of samples |
US11458473B2 (en) | 2010-04-16 | 2022-10-04 | Opko Diagnostics, Llc | Systems and devices for analysis of samples |
US9643182B2 (en) | 2010-04-16 | 2017-05-09 | Opko Diagnostics, Llc | Systems and devices for analysis of samples |
US8580569B2 (en) | 2010-04-16 | 2013-11-12 | Opko Diagnostics, Llc | Feedback control in microfluidic systems |
US9116124B2 (en) | 2010-04-16 | 2015-08-25 | Opko Diagnostics, Llc | Feedback control in microfluidic systems |
US9981266B2 (en) | 2010-04-16 | 2018-05-29 | Opko Diagnostics, Llc | Feedback control in microfluidic systems |
US10456784B2 (en) | 2010-04-16 | 2019-10-29 | Opko Diagnostics, Llc | Systems and devices for analysis of samples |
US8932523B2 (en) | 2010-04-16 | 2015-01-13 | Opko Diagnostics, Llc | Systems and devices for analysis of samples |
USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
US10672503B2 (en) | 2012-03-05 | 2020-06-02 | Opko Diagnostics, Llc | Methods and apparatuses for conducting analyses |
US10684201B2 (en) | 2013-03-13 | 2020-06-16 | Opko Diagnostics, Llc | Mixing of fluids in fluidic systems |
US9588027B2 (en) | 2013-03-13 | 2017-03-07 | UPKO Diagnostics, LLC | Mixing of fluids in fluidic systems |
US9255866B2 (en) | 2013-03-13 | 2016-02-09 | Opko Diagnostics, Llc | Mixing of fluids in fluidic systems |
US10279345B2 (en) | 2014-12-12 | 2019-05-07 | Opko Diagnostics, Llc | Fluidic systems comprising an incubation channel, including fluidic systems formed by molding |
US11253853B2 (en) | 2014-12-12 | 2022-02-22 | Opko Diagnostics, Llc | Fluidic systems comprising an incubation channel, including fluidic systems formed by molding |
CN106257243A (en) * | 2015-06-16 | 2016-12-28 | 亚诺法生技股份有限公司 | The clamping carrier of micro runner device |
USD817511S1 (en) | 2015-08-10 | 2018-05-08 | Opko Diagnostics, Llc | Multi-layered sample cassette |
USD804682S1 (en) | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
US20170056880A1 (en) * | 2015-08-26 | 2017-03-02 | EMULATE, Inc. | Fluid connections using guide mechanisms |
US10852310B2 (en) | 2015-12-11 | 2020-12-01 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
Also Published As
Publication number | Publication date |
---|---|
US20100183481A1 (en) | 2010-07-22 |
US8282896B2 (en) | 2012-10-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8282896B2 (en) | Devices and methods for holding microfluidic devices | |
JP7208210B2 (en) | Ultramicroscopic sample management device for biological fluids | |
KR102448151B1 (en) | Sequencing device | |
AU2010214783B2 (en) | Crystal forming devices and systems and methods for making and using the same | |
US5800785A (en) | Testing device for liquid and liquid suspended samples | |
EP0720508B1 (en) | Device for dialyzing samples | |
WO2018057760A1 (en) | Delivery of bodily fluids onto a fibrous substrate and associated systems and devices | |
ES2674381T3 (en) | Detection device | |
JP2023041884A (en) | Method of collecting biological fluid sample and biological fluid sample collection device | |
JP2022541880A (en) | Liquid handling and processing tools for analyzing biological samples | |
US6387710B1 (en) | Automated sample processor | |
EP2106843B1 (en) | Dialysis device with access port | |
US11490839B2 (en) | Funnel with extension tube to augment blood collection device | |
US20040253715A1 (en) | Test device | |
KR101862991B1 (en) | Sealed type Rapid Diagnostic Kit for Prevention of Secondary Infection | |
EP4245414A1 (en) | Biochip coupling systems and devices | |
US11856947B2 (en) | System for automated permeation of a biological material and method of using same | |
WO2023074574A1 (en) | Micro flow passage device | |
US20230415158A1 (en) | Sample analysis cartridge | |
WO2023119194A1 (en) | Biochip coupling system device | |
JP2006078245A (en) | Testing device | |
CN116848414A (en) | Integrated kit | |
WO2020263926A1 (en) | Sample collection device and methods of using same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: FLUIDIGM CORPORATION, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FACER, GEOFFREY RICHARD;NASSEF, HANY RAMEZ;REEL/FRAME:015606/0395;SIGNING DATES FROM 20050114 TO 20050118 |
|
AS | Assignment |
Owner name: FLUIDIGM CORPORATION - A DELAWARE CORPORATION, CAL Free format text: REINCORPORATION ASSIGNMENT;ASSIGNOR:FLUIDIGM CORPORATION - A CALIFORNIA CORPORATION;REEL/FRAME:019899/0313 Effective date: 20070928 Owner name: FLUIDIGM CORPORATION - A DELAWARE CORPORATION,CALI Free format text: REINCORPORATION ASSIGNMENT;ASSIGNOR:FLUIDIGM CORPORATION - A CALIFORNIA CORPORATION;REEL/FRAME:019899/0313 Effective date: 20070928 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |