|Número de publicación||US20060030761 A1|
|Tipo de publicación||Solicitud|
|Número de solicitud||US 11/166,344|
|Fecha de publicación||9 Feb 2006|
|Fecha de presentación||27 Jun 2005|
|Fecha de prioridad||19 Jun 1998|
|También publicado como||US6922576, US20030149348, US20070208237|
|Número de publicación||11166344, 166344, US 2006/0030761 A1, US 2006/030761 A1, US 20060030761 A1, US 20060030761A1, US 2006030761 A1, US 2006030761A1, US-A1-20060030761, US-A1-2006030761, US2006/0030761A1, US2006/030761A1, US20060030761 A1, US20060030761A1, US2006030761 A1, US2006030761A1|
|Cesionario original||Raskas Eric J|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (72), Citada por (16), Clasificaciones (14)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
This is a continuation-in-part of U.S. patent application Ser. No.09/729,611, filed on Dec. 4, 2000 which is a continuation of U.S. patent application Ser. No. 09/100,295 filed Jun. 19, 1998, now U.S. Pat. No. 6,157,442.
This invention relates generally to a sensor device and more particularly to a micro optical sensor device which may be employed in a variety of sensor applications to monitor, sense, or measure a concentration of a material within a sample.
There are numerous applications in which a device is used to monitor or detect a concentration of material within a substance. For example, it may be required to know the concentration of a chemical in a sample of material such as knowing the concentration of sodium, calcium, or some other chemical composition in a sample. Monitoring or detecting a concentration of a substance typically requires a set up of relatively complex, sensitive, and expensive equipment or instrumentation. Sometimes space requirements make it difficult to use the set up of complex equipment and it would be advantageous to have equipment which has small dimensions and is easily transportable. Additionally, such complex equipment may not provide results which are of a high resolution.
One known and important application for monitoring a concentration of a material within a sample deals with checking blood glucose for diabetics. There are at least two known techniques for monitoring blood glucose levels in humans. The two techniques are invasive which involves extracting samples with the use of needles or syringes and noninvasive. Typically, for the invasive method, a patient employs a small lancet device which is used to prick or puncture a finger. Blood is then collected onto a strip which has incorporated therein a chemical reagent. The strip is then placed inside of a device that optically reads the chemical reaction of the blood on the strip and converts this to a blood glucose level. It has been found very important to control glucose levels in diabetics to reduce any complications associated with diabetes. Many samples or finger pricks may be required to be taken for analysis during the course of a day. Self monitoring of blood glucose by a patient is therefore very important in the treatment of diabetes. Since finger pricking or lancing is required for self monitoring levels of glucose in a patient, many patients avoid this because it is painful and inconvenient. Therefore, a less invasive procedure would be desirable. The other methods, which have been termed noninvasive, typically involve a device which uses near infrared light to detect blood glucose levels. These devices measure a glucose concentration in blood or an organism's tissue by use of an optical device without the need to collect blood or fracturing a part of the organism's tissue. Although these devices use noninvasive methods, in that no blood is collected, none of these devices have been commercially accepted or viable.
The present invention is designed to obviate and overcome many of the disadvantages and shortcomings associated with the prior use of complex testing and monitoring equipment. Additionally, the present invention is simple to use, provides extremely quick results and high resolution, and is easily transportable. The present invention uses relatively inexpensive components which result in a commercially viable product. Further, the micro optical fiber sensor device of the present invention is relatively noninvasive since it does not require the drawing of blood and provides immediate results which does not require related blood processing such as centrifugation, storage, transportation, and other time consuming testing.
The present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical transmission member having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the active material interacting with a substance within a sample to change the wavelength of the emitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light out of the second end thereof, means for receiving the reflected beam of light from the second end of the sensor for producing a signal indicative of the reflected beam of light, and a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.
Another example of the present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical transmission member having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source for emitting a beam of light of a preselected wavelength with the light source being coupled to an optical device capable of transmitting the beam of light therethrough, the transmitted beam of light being directed into the first end of the sensor, through the sensor and out of the second end into a sample, the active material interacting with a substance within a sample to change the wavelength of the transmitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light from the second end, through the sensor, and out of the first end thereof, the optical device being further capable of reflecting the reflected beam of light, means for receiving the reflected beam of light which is reflected by the optical device for producing a signal indicative of the reflected beam of light; and a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.
A further example of the present invention is a sensor device for measuring a concentration of a substance within a sample which comprises a sensor comprising an optical transmission member having a first end and a second end, the second end having a tip portion attached thereto and a first and a second active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the first active material capable of interacting with a first substance within a sample and the second active material capable of interacting with a second substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the first active material interacting with a first substance within a sample to change the wavelength of the emitted beam of light to produce a first reflected beam of light, the second active material interacting with a second substance within a sample to change the wavelength of the emitted beam of light to produce a second reflected beam of light, and the sensor for transmitting the first and second reflected beams of light out of the second end thereof, means for receiving the first and second reflected beams of light from the second end of the sensor for producing a first signal indicative of the first reflected beam of light and a second signal indicative of the second reflected beam of light, and a processor for receiving the first and second signals and for processing the first and second signals to determine the concentration of a first substance within a sample and the concentration of a second substance with a sample.
In light of the foregoing comments, it will be recognized that a principal object of the present invention is to provide an improved sensor device which is hand held, portable, and easy to operate.
Another object of the present invention is to provide a sensor device which has a tip portion of an extremely small size so that when it is inserted into a hand of a patient little or no sensation will be produced or detected.
A further object of the present invention is to provide a sensor device which is of simple construction and design and which can be easily employed with highly reliable results.
Another object of the present invention is to provide a sensor device which is accurate and provides readings in a short time span.
A still further object of the present invention is to provide a sensor device which is compact in design and is easily transportable for personal use.
These and other objects and advantages of the present invention will become apparent after considering the following detailed specification in conjunction with the accompanying drawings, wherein:
Referring now to the drawings, wherein like numbers refer to like items, number 10 identifies a preferred embodiment of a micro optical sensor device constructed according to the present invention. As illustrated in
With reference now to
The optical transmission member 34 and the tip device 38 can be any device capable of transmitting light. For example, a portion of fiber optic is used in the preferred embodiment. Various types of organic polymers such as polystyrene, PMMA, polycarbonate, SAN, polyacrylonitrile and SU-8 epoxy resins can also be used. The optical transmission member can also be an inorganic alkoxysilane or a form of glass such as lead borosilicate or fused silica. The optical transmission member can be any combination of these light transmitting materials.
The beam of light 36 passes through the tip device 38 and a reflected beam of light 40 can be reflected back from a sample (not shown) through the tip device 38 to a detector 42. The reflected beam of light 40 typically has a wavelength or a frequency which is different than the wavelength or frequency of the beam of light 36. The detector 42 is in turn connected to a computer 44 via an electrical connection such as a wire 46. The detector 42 provides electrical signals over the wire 46 to the computer 44. The computer 44 may consists of, by way of examples, a microprocessor, a microcontroller, an ASIC chip, or any other known equivalent device which is capable of processing electrical signals. The computer 44 is further operatively connected to a power supply 48, such as batteries, by a wire 50. The computer 44 may also connected to the display device 20, the switch 22, and the light source 30 although such connection is not illustrated in
The tip device 38 is shown in greater detail in
As indicated above, the tip device 38 is extremely small on the order of one-thousandth the width of a human hair and because of this size it can be inserted through gaps in most cells or through the membrane of a cell without damaging the cell. The tip 70 may be bathed in chemical coatings selected to react with biological compounds such as acid, calcium, oxygen, glucose, potassium, sodium, or any other material to be detected. The beam of light 36 which is transmitted through the tip device 38 glows with its brightness and color varying according to the concentration of the target chemical. The portion 70 is a photochemical sensor which is less than ten microns in diameter. Again, the portion 70 is small enough that it can pass through the membrane of a cell to monitor the concentration and nature of chemicals within the cell.
The tip device 38 may have specific chemical sensitivities based upon the properties of a dye matrix. A dye may be chemically activated by a different chemical compound which enables sensing of a specific chemical property within a sample or a substance. The tip device. 38 provides for enhanced sensitivity, selectivity, and stability when detecting a concentration within a sample or substance. The tip portion or device 38 may comprise a biologically active compound that is immobilized in an environment that is optically reactive. Additionally, the biologically active compound can, in itself, be optically active. The sensor device 10 interacts with the substance or sample to detect a specific chemical or concentration within the substance.
With reference now to
In further detail and again with reference to
Referring now to
With particular reference now to
The sensor device 100 in actual construction is a small device and sized and shaped to be pencil like. Because of its small size the sensor device 100 may be used as a portable monitoring device. Additionally, the computer 102 may be a microprocessor chip, a customized integrated circuit chip such as an ASIC chip, or any other device which is capable of processing electrical signals. Although not shown or made reference to, a rechargeable battery or a replaceable battery may be used to power the sensor device 100. Further both devices 10 and 100 may have incorporated therein a memory for storing information such as, for example, a log of monitoring of the patient's glucose concentration, time of day of monitoring, and date of monitoring.
Since the tip device 212 is capable of monitoring two different chemicals, two different light beams, such as light beams 216 and 218, will be reflected back from a sample and through the tip device 212. Each of the light beams 216 and 218 are directed to a detector 220 and 222, respectively. Although not shown, it is possible to have an optical component, such as band pass filters, placed between the tip device 212 and the detectors 220 and 222 to direct the light beams 216 and 218 to a specific detector 220 or 222. The detector 220 is connected to the computer 202 by a wire 224 and electrical signals indicative of the concentration of a particular chemical within a sample is provided to the computer 202. Additionally, the detector 222 is connected to the computer 202 by another wire 226 and signals indicative of another chemical within the sample are provided to the computer 202. In this manner, the computer 202 is programmed to receive the signals from the detectors 220 and 222 and calculate or determine the concentrations of the two chemicals within the sample. Additionally, the sensor device 200 may include a display (not shown) which would display the results of the calculations. The sensor device 200 may also be provided with a power supply 228 which is operatively connected by a wire 230 to the computer 202. Although the device 200 is depicted to show the monitoring of at least two different chemical compounds it is also contemplated that more than two chemical compounds may be sensed, detected, or monitored by the device 200 by adding additional components, as has been taught and illustrated.
From all that has been said, it will be clear that there has thus been shown and described herein a micro optical sensor device which fulfills the various objects and advantages sought therefor. It will be apparent to those skilled in the art, however, that many changes, modifications, variations, and other uses and applications of the subject micro optical sensor device are possible and contemplated. All changes, modifications, variations, and other uses and applications which do not depart from the spirit and scope of the invention are deemed to be covered by the invention, which is limited only by the claims which follow.
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|Clasificación de EE.UU.||600/316, 600/322, 600/317|
|Clasificación internacional||G01N33/543, A61B5/00|
|Clasificación cooperativa||G01N33/5438, G01N2400/00, G01N21/8507, A61B5/14532, G01N21/78|
|Clasificación europea||A61B5/145G, G01N21/78, G01N21/85B, G01N33/543K2B|