Búsqueda Imágenes Maps Play YouTube Noticias Gmail Drive Más »
Iniciar sesión
Usuarios de lectores de pantalla: deben hacer clic en este enlace para utilizar el modo de accesibilidad. Este modo tiene las mismas funciones esenciales pero funciona mejor con el lector.

Patentes

  1. Búsqueda avanzada de patentes
Número de publicaciónUS20060184191 A1
Tipo de publicaciónSolicitud
Número de solicitudUS 11/057,300
Fecha de publicación17 Ago 2006
Fecha de presentación11 Feb 2005
Fecha de prioridad11 Feb 2005
También publicado comoCA2597369A1, EP1850765A1, US7993358, US20090192537, WO2006088621A1
Número de publicación057300, 11057300, US 2006/0184191 A1, US 2006/184191 A1, US 20060184191 A1, US 20060184191A1, US 2006184191 A1, US 2006184191A1, US-A1-20060184191, US-A1-2006184191, US2006/0184191A1, US2006/184191A1, US20060184191 A1, US20060184191A1, US2006184191 A1, US2006184191A1
InventoresDennis O'Brien
Cesionario originalBoston Scientific Scimed, Inc.
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Cutting balloon catheter having increased flexibility regions
US 20060184191 A1
Resumen
A cutting balloon catheter and method of using the same. The cutting balloon catheter may include a catheter shaft having a balloon coupled thereto. One or more cutting members or blades may be coupled to the balloon. The balloon may include one or more discrete points or areas of flexibility to enhance flexibility of the cutting balloon catheter. A break in the one or more cutting members may be aligned with the one or more discrete points of flexibility in the balloon.
Imágenes(10)
Previous page
Next page
Reclamaciones(28)
1. A medical device comprising:
an elongate shaft having a distal region;
an expandable member coupled to the distal region of the elongate shaft;
a plurality of cutting members coupled to the expandable member, wherein each cutting member includes a plurality of segments, wherein each segment is separated by a break; and
wherein the expandable member includes discrete generally circumferential area of flexibility.
2. The medical device of claim 1, wherein the discrete area of flexibility is a circumferential crease.
3. The medical device of claim 2, wherein the circumferential crease is orthogonal to the plurality of cutting members.
4. The medical device of claim 1, wherein the discrete area of flexibility is a helical crease.
5. The medical device of claim 1, wherein the expandable member includes an outer surface, wherein the discrete area of flexibility is formed in the outer surface of the expandable member.
6. The medical device of claim 1, wherein the expandable member includes an inner surface, wherein the discrete area of flexibility is formed in the inner surface of the expandable member.
7. The medical device of claim 1, wherein the discrete area of flexibility is defined by a reduced wall thickness of the expandable member.
8. The medical device of claim 1, wherein the discrete area of flexibility is defined by a reduced diameter portion.
9. The medical device of claim 1, wherein the discrete area of flexibility includes a relatively non-expandable band of material.
10. The medical device of claim 1, wherein each cutting member includes a cutting edge, wherein the break is defined as a gap in the cutting edge.
11. A medical device comprising:
an elongate shaft having a distal region;
an expandable member coupled to the distal region of the elongate shaft;
one or more cutting members coupled to the expandable member; and
wherein the expandable member includes at least one generally circumferential crease.
12. The medical device of claim 11, wherein each cutting member includes a first segment, a second segment and a break located between the first and second segments.
13. The medical device of claim 12, wherein each circumferential crease is aligned with the break of the one or more cutting members.
14. The medical device of claim 11, wherein each cutting member includes a relatively more flexible region, wherein the one or more circumferential creases are aligned with the relatively more flexible region of each cutting member.
15. The medical device of claim 11, wherein each cutting member includes a reduced thickness area, wherein the one or more circumferential creases are aligned with the reduced thickness area.
16. The medical device of claim 11, wherein the expandable member includes a relatively non-compliant material.
17. The medical device of claim 11, wherein the one or more creases are a recessed area of the expandable member.
18. The medical device of claim 11, wherein the one or more creases are a reduced diameter portion of the expandable member.
19. The medical device of claim 11, wherein the one or more cutting members traverse the one or more circumferential creases.
20. The medical device of claim 11, wherein the one or more circumferential creases are free of the one or more cutting members.
21. The medical device of claim 11, wherein the one or more circumferential creases are orthogonal to the one or more cutting members.
22. An atherotomy device comprising:
an elongate shaft having a distal region;
an expandable member coupled to the distal region of the elongate shaft;
a plurality of atherotomes disposed about the expandable member, each atherotome including a cutting edge and at least one break in the cutting edge; and
wherein the expandable member includes a generally circumferential crease at the at least one break.
23. The atherotomy device of claim 22, wherein the plurality of atherotomes are disposed equidistantly about the expandable member.
24. The atherotomy device of claim 22, wherein each atherotome includes a plurality of segments, wherein the plurality of segments is separated by the break.
25. The atherotomy device of claim 22, wherein the circumferential crease is defined by a reduced wall thickness of the expandable member.
26. The atherotomy device of claim 22, wherein the circumferential crease is a groove formed in an outer wall of the expandable member.
27. The atherotomy device of claim 22, wherein the circumferential crease is a reduced diameter portion of the expandable member.
28. The atherotomy device of claim 22, wherein the circumferential crease is orthogonal to the plurality of atherotomes.
Descripción
    TECHNICAL FIELD
  • [0001]
    The present invention pertains to angioplasty and angioplasty balloon catheters. More particularly, the present invention pertains to angioplasty balloon catheters that include one or more cutting edges coupled to an angioplasty balloon having increased flexibility.
  • BACKGROUND
  • [0002]
    Heart and vascular disease are major problems in the United States and throughout the world. Conditions such as atherosclerosis result in blood vessels becoming blocked or narrowed. This blockage can result in a lack of oxygenation to the heart, which has significant consequences since the heart muscle must be well oxygenated in order to maintain its blood pumping action.
  • [0003]
    Occluded, stenotic, or narrowed blood vessels may be treated with a number of relatively non-invasive medical procedures including percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTCA), and atherectomy. Angioplasty techniques typically involve the use of a balloon catheter. The balloon catheter may be advanced through a vasculature over a guidewire so that the balloon is positioned at a target location. The balloon may then be inflated in a manner such that the restriction in the vessel is opened.
  • [0004]
    One of the major obstacles in treating coronary artery disease and/or treating blocked blood vessels is re-stenosis. Evidence has shown that cutting the stenosis, for example with an angioplasty balloon equipped with a cutting edge, during treatment can reduce incidence of re-stenosis. Additionally, cutting the stenosis may reduce trauma at the treatment site and/or reduce the trauma to adjacent healthy tissue. Cutting blades may also be beneficial additions to angioplasty procedures when the targeted occlusion is hardened or calcified. It is believed typical angioplasty balloons, alone, may not be able to sufficiently expand at least a portion of these hardened lesions. Thus, angioplasty balloons equipped with cutting edges have been developed in an attempt to enhance angioplasty treatments. There is an ongoing need for improved angioplasty devices, including cutting angioplasty balloons, and improved methods of treating intravascular stenoses and occlusions.
  • SUMMARY
  • [0005]
    The invention generally relates to improved angioplasty devices for treating vascular abnormalities, such as a stenosis. In at least some embodiments, an exemplary angioplasty device may include a catheter shaft having a balloon coupled thereto. One or more cutting members or blades may be coupled to the balloon. The balloon may include one or more discrete points or areas of flexibility to improve the flexibility of the balloon during delivery, deployment, and/or withdrawal of an angioplasty device. Such discrete points or areas of flexibility may include one or more creases, folds, reduced diameter portions, less expandable portions, regions of reduced wall thickness, and the like, formed in a portion of the balloon.
  • [0006]
    Accordingly, one exemplary embodiment of the invention is a cutting balloon catheter including a balloon having one or more generally circumferentially extending creases formed in the balloon wall. One or more cutting members may be coupled to the balloon such that breaks in the cutting members, or segments thereof, are aligned with the one or more creases to impart greater flexibility to the balloon portion.
  • [0007]
    Another embodiment of the invention includes an atherotomy device for the treatment of coronary artery disease. The atherotomy device includes a plurality of cutting edges or atherotomes coupled to an inflatable balloon. The atherotomes may be segmented to provide flexibility. The balloon may also include at least one circumferential crease to improve the flexibility of the balloon during an atherotomy procedure. The flexibility provided by the at least one circumferential crease and/or the segmented atherotomes allows the cutting balloon to more readily conform to the curvature of a vascular passageway. Balloons not having such flexibility may tend to straighten as they are inflated in a curved vascular pathway, thereby placing uneven pressure on the wall of the vessel and subjecting unnecessary trauma to the vessel.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0008]
    The invention may be more completely understood in consideration of the following detailed description of various embodiments of the invention in connection with the accompanying drawings, in which:
  • [0009]
    FIG. 1 is a partial cross-sectional view of a representative cutting balloon catheter in accordance with an embodiment of the invention;
  • [0010]
    FIG. 2 is a partial perspective view of a representative cutting member and balloon having at least one generally circumferentially extending crease in accordance with an embodiment of the invention;
  • [0011]
    FIG. 3 is a partial perspective view of another representative cutting member and balloon having at least one generally circumferentially extending crease in accordance with an embodiment of the invention;
  • [0012]
    FIG. 4 is a partial perspective view of a representative cutting balloon catheter including a balloon having at least one crease in accordance with an embodiment of the invention;
  • [0013]
    FIG. 5 is a partial perspective view of another representative cutting balloon catheter including a balloon having at least one crease in accordance with an embodiment of the invention;
  • [0014]
    FIG. 6 is a partial perspective view of another representative cutting balloon catheter including a balloon having at least one crease in accordance with an embodiment of the invention;
  • [0015]
    FIG. 7 is a partial cross-sectional view of a representative cutting balloon catheter disposed in a curved vasculature;
  • [0016]
    FIG. 8 is a partial perspective view of another representative cutting balloon catheter including a multi-lobed balloon; and
  • [0017]
    FIG. 9 is a partial perspective view of another representative cutting balloon catheter including a plurality of expandable balloons.
  • DETAILED DESCRIPTION
  • [0018]
    For the following defined terms, these definitions shall be applied, unless a different definition is given in the claims or elsewhere in this specification.
  • [0019]
    All numeric values are herein assumed to be modified by the term “about”, whether or not explicitly indicated. Unless indicated otherwise, the term “about” generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited value (i.e., having the same function or result). In many instances, the term “about” may include numbers that are rounded to the nearest significant figure.
  • [0020]
    The recitation of numerical ranges by endpoints includes all numbers within that range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5). As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.
  • [0021]
    The following detailed description should be read with reference to the drawings in which similar elements in different drawings are numbered the same. The detailed description and the drawings, which are not necessarily to scale, depict illustrative embodiments and are not intended to limit the scope of the invention. The illustrative embodiments depicted are intended only as exemplary. Selected features of any illustrative embodiment may be incorporated into an additional embodiment unless clearly stated to the contrary.
  • [0022]
    FIG. 1 is a partial cross-sectional side view of an exemplary catheter 10 disposed in a blood vessel 12 and positioned adjacent an intravascular lesion 14. Catheter 10 may include a balloon 16 coupled to a catheter shaft 18. One or more cutting members or blades 20 may be coupled to balloon 16. In general, catheter 10 may be advanced over a guidewire 22, through the vasculature, to a target area. Balloon 16 can then be inflated to expand lesion 14, and cutting members 20 may cut lesion 14. The target area may be within any suitable peripheral, cardiac or other vessel lumen location.
  • [0023]
    Cutting members 20 may vary in number, position, and arrangement about balloon 16. For example, catheter 10 may include one, two, three, four, five, six, or more cutting members 20 that are disposed at any position along balloon 16 and in a regular, irregular, or any other suitable pattern. The pattern can include a generally helical orientation of the cutting members 20. Catheter 10 may include a plurality of cutting members 20 placed equidistantly about balloon 16 extending generally longitudinally. In general, cutting members 20 may be configured to provide variable flexibility or otherwise vary the flexibility of catheter 10. Increasing the flexibility of cutting members 20, balloon 16, and/or catheter 10 may be desirable, for example, because it may improve the tracking ability and general deliverability of catheter 10 through the often tortuous anatomy. Additionally, increasing the flexibility may allow catheter 10 to be navigable to a larger number of intravascular locations, including some that may not be readily reachable by other, less flexible, cutting balloon catheters. In general, the enhanced flexibility may be the result of a structural feature of cutting members 20, a structural modification to cutting members 20, and/or a structural feature of the cutting balloon 16. For example, cutting members 20 may include a first section 44 a, a second section 44 b, and a gap or break 46 disposed between first section 44 a and second section 44 b. Break 46 may be configured to provide a region of flexibility such as a space between first section 44 a and second section 44 b. In some embodiments, break 46 may be defined by a downward deflection or slot that is formed in the cutting surface of cutting member 20. Alternatively, break 46 may not be a physical gap between first section 44 a and second section 44 b, but rather break 46 may be a region of cutting member 20 having a reduced wall thickness or may comprise a material having an increased flexibility relative to the material of first and second sections 44 a, 44 b. Break 46 also may comprise an exogenous connector that is connected to both first section 44 a and second section 44 b in order to bridge sections 44 a, 44 b. Separation of sections 44 a, 44 b can increase the flexibility of cutting member 20 and/or the overall flexibility of catheter 10.
  • [0024]
    Cutting members 20 may be made from any suitable material such as a metal, metal alloy, polymer, metal-polymer composite, and the like, or any other suitable material. For example, cutting members 20 may be made from stainless steel such as 304V, 304L, or 316L stainless steel. In other embodiments, cutting member 20 can be made from a glass/KEVLAR® complex material such as ARAMAT®, which is commercially available. Some examples of other suitable materials are listed below in relation to balloon 16 and shaft 18.
  • [0025]
    Balloon 16 may be made from typical angioplasty balloon materials including polymers such as polyethylene terephthalate (PET), polyetherimide (PEI), polyethylene (PE), etc. Some other examples of suitable polymers, including lubricious polymers, may include polytetrafluoroethylene (PTFE), ethylene tetrafluoroethylene (ETFE), fluorinated ethylene propylene (FEP), polyoxymethylene (POM), polybutylene terephthalate (PBT), polyether block ester, polyurethane, polypropylene (PP), polyvinylchloride (PVC), polyether-ester (for example, a polyether-ester elastomer such as ARNITEL® available from DSM Engineering Plastics), polyester (for example, a polyester elastomer such as HYTREL® available from DuPont), polyamide (for example, DURETHAN® available from Bayer or CRISTAMID® available from Elf Atochem), elastomeric polyamides, block polyamide/ethers, polyether block amide (PEBA, for example, available under the trade name PEBAX®), silicones, Marlex high-density polyethylene, Marlex low-density polyethylene, linear low density polyethylene (for example, REXELL®), polyetheretherketone (PEEK), polyimide (PI), polyphenylene sulfide (PPS), polyphenylene oxide (PPO), poly(ethylene naphthalenedicarboxylate) (PEN), polysulfone, nylon, perfluoro(propyl vinyl ether) (PFA), other suitable materials, or mixtures, combinations, copolymers thereof, polymer/metal composites, and the like. In some embodiments, it may be desirable to use a relatively non-compliant balloon or a balloon including high modulus or generally stiffer materials so as to reduce balloon elongation. The above list of materials includes some examples of higher modulus materials. Some other examples of stiffer materials include polymers blended with liquid crystal polymer (LCP) as well as the materials listed above. For example, the mixture can contain up to about 5% LCP. Balloon 16 may include fiber, particulate material, or other reinforcing filaments. For example, balloon 16 may comprise a nanocomposite polymer material.
  • [0026]
    Balloon 16 may be configured so that it includes one or more “wings” or wing-shaped regions when balloon 16 is deflated. These wings may appear as a plurality of alternating inward and outward radial deflections in balloon 16 when balloon 16 is deflated. These wings may be desirable for a number of reasons. For example, by including balloon 16 with wings, balloon 16 may have more predictable and consistent re-folding characteristics. Additionally, the wings may be configured so that cutting members 20 can be positioned at the inward-most positions of the deflated balloon 16. This arrangement allows cutting members 20 to be positioned more closely to shaft 18 when balloon 16 is deflated. Accordingly, cutting members 20 can be moved away from the vessel walls where they might otherwise result in contact and, possibly, damage to healthy tissue during movement of catheter 10 within a body lumen. Additionally, alternating the wings and cutting members 20 as well as positioning cutting members 20 relatively close to shaft 18 may allow the wings to fold over and cover cutting members 20 when balloon 16 is deflated. Again, this feature may reduce the exposure of cutting members 20 to the blood vessel.
  • [0027]
    Balloon 16 additionally may include one or more discrete points or areas of flexibility such as generally circumferentially extending crease 70 formed in the wall of balloon 16. A single crease 70 is shown in FIG. 1; however, two, three, or more creases 70 may be present in balloon 16 to provide a desired flexibility to a distal region of catheter 10. Crease 70 may provide increased flexibility to the distal portion of catheter 10 including balloon 16 during delivery, deployment, and withdrawal of a medical device within a vasculature. Crease 70 may allow balloon 16 having cutting members 20 to readily bend through a curved vascular pathway and maintain conformity to a vessel lumen during inflation of balloon 16 at a target location. Balloons not having such flexibility may tend to straighten as they are inflated in a curved vascular pathway, thereby placing uneven pressure on the wall of the vessel and/or causing unnecessary trauma to the vessel.
  • [0028]
    Crease 70 may be a circumferential crease, a helical crease, or the like. For example, crease 70 may be disposed substantially orthogonal to cutting member 20 or at an angle thereto. For instance, crease 70 may be formed at a 45-, 60-, 75-, 80- or 90-degree angle relative to cutting member 20. Preferably, crease 70 corresponds with break 46 in cutting member 20. For example, cutting member 20 may be positioned on balloon 16 such that break 46 of cutting member 20 is aligned with crease 70. As shown in FIG. 1, first section 44 a may be positioned proximal of crease 70 and second section 44 b may be positioned distal of crease 70, such that break 46 is substantially aligned with crease 70.
  • [0029]
    Crease 70 may be formed in balloon 16 during a molding process, such as a blow molding process, prior to placing cutting members 20 on balloon 16. Alternatively, crease 70 may be formed in balloon 16 during a balloon folding operation subsequent to placing cutting members 20 on balloon 16. A balloon folding fixture may include means for creasing balloon 16, such as notches, ridges, and the like. The balloon 16 may be positioned in a folding fixture such that break 46 of cutting member 20 is aligned with the means for creasing balloon 16. In this process, crease 70 may be fashioned in the balloon 16 during a final folding operation. Alternatively or additionally, crease 70 may be formed by grinding, laser ablating, chemical etching, or ablation and subsequent back fill with a more compliant material, for example.
  • [0030]
    Crease 70 may be located on the outer surface 40 of balloon 16 or on the inner surface (not shown) of balloon 16. Crease 70 may be a fold created in balloon 16. Alternatively, crease 70 may be defined as a portion of balloon 16 having a reduced wall thickness, a groove, a reduced diameter portion, or recessed area defined in the wall of balloon 16, for example. Crease 70 may also be a portion of balloon 16 comprising a material relatively resistant to expansion. Additionally, crease 70 may be formed by a band of relatively non-expandable material disposed about a portion of balloon 16 or incorporated in a portion of balloon 16. The band of relatively non-expandable material may constrain a portion of balloon 16 from readily expanding to the extent of adjacent regions.
  • [0031]
    It is also contemplated that balloon 16 may additionally and/or alternatively include at least one crease 70 not aligned with a break 46 in cutting members 20. Such a crease 70 may provide enhanced flexibility along at least a portion of balloon 16. Some further discussion of crease 70 and other examples, features, and modifications are described in more detail below.
  • [0032]
    Shaft 18 may be a catheter shaft, similar to typical catheter shafts. For example, shaft 18 may include an inner tubular member 24 and outer tubular member 26. Tubular members 24/26 may be manufactured from a number of different materials. For example, tubular members 24/26 may be made of metals, metal alloys, polymers, metal-polymer composites or any other suitable materials. Some examples of suitable metals and metal alloys include stainless steel, such as 300 series stainless steel (including 304V, 304L, and 316L); 400 series martensitic stainless steel; tool steel; nickel-titanium alloy such as linear-elastic or super-elastic Nitinol, nickel-chromium alloy, nickel-chromium-iron alloy, cobalt alloy, tungsten or tungsten alloys, MP35-N (having a composition of about 35% Ni, 35% Co, 20% Cr, 9.75% Mo, a maximum 1% Fe, a maximum 1% Ti, a maximum 0.25% C, a maximum 0.15% Mn, and a maximum 0.15% Si), hastelloy, monel 400, inconel 825, or the like; or other suitable material. Some examples of suitable polymers include those described above in relation to balloon 16. For example, tubular members 24/26 may comprise a reinforced polymer material such as a nanocomposite polymer material. Of course, any other polymer or other suitable material including ceramics may be used without departing from the spirit of the invention. The materials used to manufacture inner tubular member 24 may be the same as or be different from the materials used to manufacture outer tubular member 26. Those materials listed herein may also be used for manufacturing other components of catheter 10 including cutting members 20.
  • [0033]
    Tubular members 24/26 may be arranged in any appropriate way. For example, in some embodiments, inner tubular member 24 can be disposed coaxially within outer tubular member 26. According to these embodiments, inner and outer tubular members 24/26 may or may not be secured to one another along the general longitudinal axis of shaft 18. Alternatively, inner tubular member 24 may follow the inner wall or otherwise be disposed adjacent the inner wall of outer tubular member 26. Again, inner and outer tubular members 24/26 may or may not be secured to one another. For example, inner and outer tubular members 24/26 may be bonded, welded (including tack welding or any other welding technique), or otherwise secured at a bond point. In some embodiments, the bond point may be generally disposed near the distal end of shaft 18. However, one or more bond points may be disposed at any position along shaft 18. The bond may desirably impact, for example, the stability and the ability of tubular members 24/26 to maintain their position relative to one another. In still other embodiments, inner and outer tubular member 24/26 may be adjacent to and substantially parallel to one another so that they are non-overlapping. In these embodiments, shaft 18 may include an outer sheath that is disposed over tubular members 24/26.
  • [0034]
    Inner tubular member 24 may include an inner lumen 28. In at least some embodiments, inner lumen 28 is a guidewire lumen. Accordingly, catheter 10 can be advanced over guidewire 22 to the desired location. The guidewire lumen may extend along essentially the entire length of catheter shaft 18 so that catheter 10 resembles a traditional “over-the-wire” catheter. Alternatively, the guidewire lumen may extend along only a portion of shaft 18 so that catheter 10 resembles a “single-operator-exchange” or “rapid-exchange” catheter. Regardless of which type of catheter is contemplated, catheter 10 may be configured so that balloon 16 is disposed over at least a region of inner lumen 28. In at least some of these embodiments, inner lumen 28 (i.e., the portion of inner lumen 28 that balloon 16 is disposed over) may be substantially coaxial with balloon 16.
  • [0035]
    Shaft 18 may also include an inflation lumen 30 that may be used, for example, to transport inflation media to and from balloon 16. The location and position of inflation lumen 30 may vary, depending on the configuration of tubular members 24/26. For example, when outer tubular member 26 is disposed over inner tubular member 24, inflation lumen 30 may be defined within the space between tubular members 24/26. Moreover, depending on the position of inner tubular member 24 within outer tubular member 26, the shape of lumen 30 (i.e., the shape adjacent shaft 18) may vary. For example, if inner tubular member 24 is attached to or disposed adjacent to the inside surface of outer tubular member 26, then inflation lumen 30 may be generally half-moon in shape; whereas, if inner tubular member 24 is generally coaxial with outer tubular member 26, then inflation lumen 30 may be generally ring-shaped or annular in shape. It can be appreciated that if outer tubular member 26 is disposed alongside inner tubular member 24, then lumen 30 may be the lumen of outer tubular member 26 or it may be the space defined between the outer surface of tubular members 24/26 and the outer sheath disposed thereover.
  • [0036]
    Balloon 16 may be coupled to catheter shaft 18 in any of a number of suitable ways. For example, balloon 16 may be adhesively or thermally bonded to shaft 18. Such bonding techniques may include laser welding, heat shrinking, adhesive, and tie layers, for example. In some embodiments, a proximal waist 32 of balloon 16 may be bonded to shaft 18, for example, at outer tubular member 26, and a distal waist 34 may be bonded to shaft 18, for example, at inner tubular member 24. The exact bonding positions, however, may vary. It can be appreciated that a section of proximal waist 32 may not have sections 36 extending therefrom in order for suitable bonding between balloon 16 and outer tubular member 30.
  • [0037]
    In addition to some of the structures described above, shaft 18 may also include a number of other structural elements, including those typically associated with catheter shafts. For example, shaft 18 may include a radiopaque marker coupled thereto that may aid a user in determining the location of catheter 10 within the vasculature. In addition, catheter 10 may include a folding spring (not shown) coupled to balloon 16, for example, adjacent proximal waist 32, which may further help in balloon folding and refolding. A description of a suitable folding spring can be found in U.S. Pat. No. 6,425,882, the disclosure of which is incorporated herein by reference.
  • [0038]
    An exploded view illustrating the attachment of cutting member 20 to balloon 16 is shown in FIG. 2. Here it can be seen that a joining member or polymeric strip 38 may be coupled to cutting member 20 and to balloon 16. Joining member 38 may be formed from a generally flexible or soft material that allows the interface between cutting member 20 and balloon 16 to be somewhat elastic or pliable. For example, joining member 38 may be manufactured from a low durometer polyurethane or any other suitable material (including any of the polymers and other materials disclosed herein). Accordingly, cutting member 20 may be securely coupled to balloon 16 while still being able to move laterally about eight degrees or less. In addition, different portions of cutting member 20 may be able to bend or flex, while other portions remain essentially unchanged.
  • [0039]
    In at least some embodiments, joining member 38 may be attached to and disposed between cutting member 20 and balloon 16. For example, joining member 38 may be attached to an outer surface 40 of balloon 16 and to a base 50 of the cutting member 20. The attachment of joining member 38 with cutting member 20 and balloon 16 may be achieved in any appropriate manner, such as by adhesive bonding, casting, thermal bonding, mechanically connecting, welding, brazing, and the like, or in any other suitable way. The attachment means need not be the same for the attachment between cutting member 20 and joining member 38 as the means used to attach balloon 16 and joining member 38.
  • [0040]
    Balloon 16 may include a discrete region of flexibility such as crease 70 formed in the outer surface 40 of balloon 16. Break 46 of cutting member 20 may be aligned with crease 70 such that the increased flexibility of balloon 16 provided by crease 70 may be combined with the increased flexibility of cutting member 20 provided by break 46. The enhanced flexibility of balloon 16 may improve the deliverability of the catheter, as well as the conformity of balloon 16 to a vessel lumen curvature during inflation of balloon 16.
  • [0041]
    FIG. 3 depicts a partial perspective view of another catheter 110 that is similar to catheter 10. Catheter 110 includes cutting members 120 disposed about balloon 16 in a tandem arrangement. In other words, two cutting members 120 may be arranged end-to-end to define an elongated cutting surface. This embodiment may increase the flexibility of cutting members 120 by dividing what might otherwise be a single cutting blade into multiple discrete sections. Thus, the cutting members 120 may individually have a shortened length, making balloon 16 more amenable to bending or flexing. It can be appreciated that the precise arrangement of cutting members 120 is not intended to be limited to a tandem configuration. For example, cutting members 120 may have an arrangement that is longitudinally offset. Additionally, catheter 110 is not limited to pairs of cutting members 120, as any suitable number of cutting members 120 may be used without departing from the spirit of the invention.
  • [0042]
    It can also be seen in FIG. 3 that cutting members 120 may be positioned on either side of crease 70 in balloon 16. As illustrated in this embodiment, crease 70 may be a reduced diameter portion or material offset of balloon 16. Crease 70 provides increased flexibility to the balloon 16. Placing cutting members 120 on either side of crease 70 provides flexibility to the balloon 16 while maintaining sufficient functionality of balloon 16 necessary to perform a medical procedure at a target location. Joining member 38 may extend over crease 70, or joining member 38 may terminate proximate crease 70. Alternatively, joining member 38 may be absent from catheter assembly 110.
  • [0043]
    FIG. 4 depicts a perspective view of a catheter 210 similar to catheter 10. Catheter 210 includes a balloon 216 disposed about a distal region of catheter 210. Balloon 216 includes a helical crease 270 disposed about the outer surface 240 of balloon 216. Cutting members 220 may be arranged about balloon 216 such that cutting members 220 are coupled away from crease 270. In other words, cutting members 220 are positioned such that they do not extend over helical crease 270. Alternately, cutting members 220 may extend substantially the length of balloon 216, thereby traversing crease 270. Helical crease 270 may provide increased flexibility of the balloon 216 during a medical procedure.
  • [0044]
    FIG. 5 is a perspective view of a catheter 310 similar to catheter 10. Balloon 316 may include a plurality of creases 370. As shown in FIG. 5, balloon 316 may include two creases 370 extending around the circumference of balloon 316. However, it should be recognized that balloon 316 may include additional creases 370. A plurality of cutting members 320 may be coupled to the balloon 316. Preferably, cutting members 320 are coupled equidistantly about balloon 316. Cutting member 320 may extend substantially the length of balloon 316 or a portion thereof. As shown in FIG. 5, cutting member 320 may include a plurality of integral segments separated with a break 346 therebetween. Each cutting member 320 is positioned such that break 346 is aligned with crease 370. In other words, cutting member 320 may be positioned such that break 346 is located at the same longitudinal position along balloon 316 as crease 370. Aligning break 346 with crease 370 provides balloon 316 with defined flexibility regions along its length.
  • [0045]
    FIG. 6 depicts a perspective view of catheter 410 similar to catheter 10. Catheter 410 includes an expandable member 416 including at least one crease 470. Crease 470 may be a portion of expandable member 416 having a reduced diameter relative to proximal balloon section 430 and distal balloon section 440. A plurality of cutting members 420 may be coupled to balloon 416. Each cutting member 420 may extend along substantially the length of proximal section 430 or distal section 440, thereby leaving crease 470 free of cutting members 420. Therefore, a flexibility region may be formed at crease 470 to impart greater flexibility in balloon 416.
  • [0046]
    FIG. 7 shows a representative catheter disposed in a vessel having a curved profile. Catheter 410 is shown in FIG. 7; however, catheter 410 may be replaced with other representative embodiments or any combination thereof disclosed herein. Catheter 410 may be advanced through the vasculature over guidewire 422 until expandable member 416 reaches a target location such as stenosis 414. Stenosis 414 may be located in a curved portion of vessel 412. As expandable member 416 is expanded, cutting members 420 may contact stenosis 414. Crease 470 allows expandable member 416 to maintain a curved profile while being expanded. Therefore, cutting members 420 may contact stenosis 414 along a longer portion of the curved region, reducing trauma to the vessel 412 and/or minimizing the need for additional procedures. Additionally, pressure within expandable member 416 may be more evenly transmitted throughout expandable member 416 when expandable member 416 conforms to the curvature of vessel 412 attributable at least in part to crease 470. Therefore, cutting members 420 may contact stenosis 414 more uniformly and along a longer portion of their length.
  • [0047]
    FIG. 8 shows a catheter 510 including a multi-lobed balloon 516. Multi-lobed balloon 516 includes three segments or lobes 516 a, 516 b, 516 c. However, balloon 516 may include two, three, four, five, six or more lobes. Multi-lobed balloon 516 may be coupled to a distal portion of catheter 510. Lobes may be formed in balloon 516 in a variety of ways. For example, a band 575 may be disposed about a portion of balloon 516 restraining a portion of balloon 516 from expanding, thereby allowing a portion of balloon 516 to expand while constraining an adjacent portion by band 575. Band 575 may be a discrete, relatively non-expandable member disposed about a portion of balloon 516. Instead, balloon may be made of a material having alternating portions. For example band 575 may be a portion of balloon 516 including a relatively non-expandable material while lobes 516 a, 516 b, 516 c may include a relatively expandable material. Alternatively or additionally, band 575 may be a portion of balloon 516 of a greater thickness than adjacent lobes 516 a, 516 b, 516 c. Portions of material of a greater thickness may not expand as readily as adjacent areas having a thinner thickness, thereby allowing lobes 516 a, 516 b, 516 c to expand while band 575 retains a reduced cross-sectioned profile.
  • [0048]
    One or more cutting members 520 may be coupled to balloon 516. As shown in FIG. 8, the one or more cutting members 520 may extend substantially the length of balloon 516. Alternatively, cutting members 520 may individually be coupled to one of lobes 516 a, 516 b, 516 c, therefore not extending over a reduced cross-sectioned region 570. Cutting members 520 may include one or more flexibility regions or breaks 546 for increased flexibility. Preferably, break 546 in cutting member 520 may be aligned with reduced cross-sectioned region 570 to impart enhanced flexibility to catheter 510. In other words, cutting member 520 may be positioned such that break 546 is located at the same longitudinal position of balloon 516 as band 575. Such an arrangement may provide catheter 510 with sufficient flexibility to navigate a tortuous vasculature and retain a curved configuration during inflation of balloon 516 at a target location.
  • [0049]
    FIG. 9 shows a catheter 610 having a distal portion 630 including a plurality of balloons 616 a, 616 b. Although FIG. 9 shows a catheter 610 having two balloons 616 a, 616 b, it is contemplated that catheter 610 may include two, three, four, five, six or more balloons 616. Proximal balloon 616 a may be secured to catheter 610 at proximal waist 611 and intermediate waist 615. Distal balloon 616 b may be secured to catheter 610 at distal waist 613 and intermediate waist 615. Intermediate waist 615 may be a portion of proximal balloon 616 a, distal balloon 616 b, or intermediate waist 615 may be a portion shared with proximal balloon 616 a and distal balloon 616 b. Balloon 616 a may be integrally connected with balloon 616 b by intermediate waist 615. Intermediate waist 615 may be secured to catheter 610 in any of a number of suitable ways. For example, intermediate waist 615 may be adhesively or thermally bonded to catheter 610, or intermediate waist 615 may be secured to catheter 610 by a discrete member such as a heat shrink tube, coupler, generally inelastic member, or the like. Such bonding techniques may include laser welding, heat shrinking, adhesive, and tie layers, for example. Alternatively, balloons 616 a, 616 b may comprise two discrete elements each having an intermediate waist 615 secured to catheter 610. Balloons 616 a, 616 b may be independently expanded, expanded simultaneously, or expanded in series.
  • [0050]
    A plurality of cutting members 620 may be coupled to balloons 616 a, 616 b. Preferably, each balloon 616 a, 616 b may include three cutting members 620 disposed equidistantly about balloon 616 a, 616 b. However, each balloon 616 a, 616 b may include one, two, three, four, five, six or more cutting members 620.
  • [0051]
    Intermediate waist 615 may define a reduced cross-sectioned region 670 of distal portion 630 of catheter 610 while balloons 616 a, 616 b are expanded. Therefore, reduced cross-sectioned region 670 may provide a discrete point of flexibility in the distal region 630 of catheter 610. In an expanded state, the distal region 630 of catheter 610 may readily conform to the curvature of a vessel due to a discrete point of flexibility 670 provided by intermediate waist 615. The enhanced flexibility of distal portion 630 may allow expansion of balloons 616 a, 616 b within a vessel without surrendering compliance to a curvature of a vessel. Therefore, catheter 610 may be designed to sufficiently treat a stenosis located in a sharply curved portion of a vessel.
  • [0052]
    Those skilled in the art will recognize that the present invention may be manifested in a variety of forms other than the specific embodiments described and contemplated herein. It is contemplated that one may combine, substitute, or modify specific elements of the various embodiments described herein without departing from the scope and spirit of the invention. Accordingly, departure in form and detail may be made without departing from the scope and spirit of the present invention as described in the appended claims.
Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US3174851 *1 Dic 196123 Mar 1965Buehler William JNickel-base alloys
US3557794 *30 Jul 196826 Ene 1971Us Air ForceArterial dilation device
US3635223 *2 Dic 196918 Ene 1972Us Catheter & Instr CorpEmbolectomy catheter
US4018231 *2 Jun 197519 Abr 1977Airco, Inc.Disposable balloon type catheter
US4140126 *18 Feb 197720 Feb 1979Choudhury M HasanMethod for performing aneurysm repair
US4141364 *18 Mar 197727 Feb 1979Jorge SchultzeExpandable endotracheal or urethral tube
US4248246 *5 Jul 19793 Feb 1981Terumo CorporationSampling needle protector
US4263236 *21 Ago 197821 Abr 1981Matburn (Holdings) LimitedMethod for producing catheters
US4444186 *15 Jun 198124 Abr 1984Datascope CorporationEnvelope wrapping system for intra-aortic balloon
US4449532 *30 Jun 198122 May 1984Karl StorzDilator to facilitate endoscope insertion into the body
US4572186 *7 Dic 198325 Feb 1986Cordis CorporationVessel dilation
US4573470 *30 May 19844 Mar 1986Advanced Cardiovascular Systems, Inc.Low-profile steerable intraoperative balloon dilitation catheter
US4574781 *24 Sep 198111 Mar 1986Thomas J. FogartyEndarterectomy process
US4576142 *19 Nov 198218 Mar 1986Peter SchiffPercutaneous intra-aortic balloon and method for using same
US4636201 *1 Nov 198513 Ene 1987American Hospital Supply CorporationHypodermic syringe having a protective sheath cover
US4723549 *18 Sep 19869 Feb 1988Wholey Mark HMethod and apparatus for dilating blood vessels
US4728319 *21 May 19861 Mar 1988Helmut MaschIntravascular catheter
US4738666 *28 Ene 198719 Abr 1988Genus Catheter Technologies, Inc.Variable diameter catheter
US4743258 *12 Abr 198510 May 1988Japan Medical Supply Co., Ltd.Polymer materials for vascular prostheses
US4747405 *16 Sep 198631 May 1988Vaser, Inc.Angioplasty catheter
US4796629 *3 Jun 198710 Ene 1989Joseph GrayzelStiffened dilation balloon catheter device
US4799479 *8 Ene 198724 Ene 1989The Beth Israel Hospital AssociationMethod and apparatus for angioplasty
US4820349 *21 Ago 198711 Abr 1989C. R. Bard, Inc.Dilatation catheter with collapsible outer diameter
US4896669 *31 Ago 198830 Ene 1990Meadox Medicals, Inc.Dilatation catheter
US4906244 *24 Jul 19896 Mar 1990Cordis CorporationBalloons for medical devices and fabrication thereof
US4909781 *19 Jul 198920 Mar 1990Husted Royce HillCatheter with flexible cutter
US4921483 *23 Sep 19871 May 1990Leocor, Inc.Angioplasty catheter
US4983167 *23 Nov 19888 Ene 1991Harvinder SahotaBalloon catheters
US4986807 *23 Ene 198922 Ene 1991Interventional Technologies, Inc.Atherectomy cutter with radially projecting blade
US4994018 *31 May 198919 Feb 1991Datascope CorporationIntra-aortic balloon assembly
US4994072 *30 Ago 198919 Feb 1991Meadox Medicals, Inc.Dilation catheter
US5009659 *30 Oct 198923 Abr 1991Schneider (Usa) Inc.Fiber tip atherectomy catheter
US5078722 *14 Ago 19907 Ene 1992Cordis CorporationMethod and apparatus for removing deposits from a vessel
US5078725 *9 Nov 19897 Ene 1992C. R. Bard, Inc.Balloon catheter and techniques for dilating obstructed lumens and other luminal procedures
US5084010 *20 Feb 199028 Ene 1992Devices For Vascular Intervention, Inc.System and method for catheter construction
US5085662 *13 Nov 19894 Feb 1992Scimed Life Systems, Inc.Atherectomy catheter and related components
US5087246 *29 Dic 198811 Feb 1992C. R. Bard, Inc.Dilation catheter with fluted balloon
US5087265 *24 Jul 198911 Feb 1992American Biomed, Inc.Distal atherectomy catheter
US5100424 *21 May 199031 Mar 1992Cardiovascular Imaging Systems, Inc.Intravascular catheter having combined imaging abrasion head
US5100425 *14 Sep 198931 Mar 1992Medintec R&D Limited PartnershipExpandable transluminal atherectomy catheter system and method for the treatment of arterial stenoses
US5102390 *2 May 19857 Abr 1992C. R. Bard, Inc.Microdilatation probe and system for performing angioplasty in highly stenosed blood vessels
US5102403 *18 Jun 19907 Abr 1992Eckhard AltTherapeutic medical instrument for insertion into body
US5176693 *11 May 19925 Ene 1993Interventional Technologies, Inc.Balloon expandable atherectomy cutter
US5178625 *19 Dic 199112 Ene 1993Evi CorporationCatheter atherotome
US5180368 *11 Oct 199119 Ene 1993Advanced Cardiovascular Systems, Inc.Rapidly exchangeable and expandable cage catheter for repairing damaged blood vessels
US5181920 *10 Dic 199026 Ene 1993Devices For Vascular Intervention, Inc.Atherectomy device with angioplasty balloon and method
US5192291 *13 Ene 19929 Mar 1993Interventional Technologies, Inc.Rotationally expandable atherectomy cutter assembly
US5192296 *29 Nov 19909 Mar 1993Meadox Medicals, Inc.Dilatation catheter
US5195970 *26 Abr 199123 Mar 1993Gahara William JCollapsible balloon catheters
US5196024 *3 Jul 199023 Mar 1993Cedars-Sinai Medical CenterBalloon catheter with cutting edge
US5196025 *21 May 199023 Mar 1993Ryder International CorporationLancet actuator with retractable mechanism
US5295959 *13 Mar 199222 Mar 1994Medtronic, Inc.Autoperfusion dilatation catheter having a bonded channel
US5295995 *27 Ago 199222 Mar 1994Kleiman Jay HPerfusion dilatation catheter
US5300025 *30 Sep 19925 Abr 1994Advanced Cardiovascular Systems, Inc.Dilatation catheter having a coil supported inflation lumen
US5306246 *11 Sep 199226 Abr 1994Boston Scientific CorporationBalloon for medical catheter
US5395361 *16 Jun 19947 Mar 1995Pillco Limited PartnershipExpandable fiberoptic catheter and method of intraluminal laser transmission
US5399164 *2 Nov 199221 Mar 1995Catheter Imaging SystemsCatheter having a multiple durometer
US5403334 *1 Oct 19934 Abr 1995Devices For Vascular Intervention, Inc.Atherectomy device having helical blade and blade guide
US5409454 *2 May 199425 Abr 1995Arrow International Investment Corp.Apparatus for atherectomy
US5487730 *27 May 199430 Ene 1996Medtronic, Inc.Balloon catheter with balloon surface retention means
US5490839 *22 May 199513 Feb 1996Scimed Life Systems, Inc.Catheter balloon with retraction coating
US5496308 *27 Dic 19935 Mar 1996Brown; JosephRadial laser delivery device
US5507760 *9 Nov 199316 Abr 1996Devices For Vascular Intervention, Inc.Cutter device
US5507761 *11 Oct 199416 Abr 1996Duer; Edward Y.Embolic cutting catheter
US5616149 *28 Mar 19941 Abr 1997Cedars-Sinai Medical CenterBalloon catheter with cutting edge
US5713913 *12 Nov 19963 Feb 1998Interventional Technologies Inc.Device and method for transecting a coronary artery
US5718684 *24 May 199617 Feb 1998Gupta; MukeshMulti-lobed balloon catheter
US5720724 *24 Sep 199624 Feb 1998Scimed Life Systems, Inc.Intravascular catheter with distal guide wire lumen and transition member
US5728123 *26 Abr 199517 Mar 1998Lemelson; Jerome H.Balloon actuated catheter
US5730698 *9 May 199524 Mar 1998Fischell; Robert E.Balloon expandable temporary radioisotope stent system
US5743875 *4 Nov 199628 Abr 1998Advanced Cardiovascular Systems, Inc.Catheter shaft with an oblong transverse cross-section
US5860954 *29 Sep 199719 Ene 1999Boston Scientific CorporationMultiple hole drug delivery balloon
US5895402 *17 Ene 199720 Abr 1999Hundertmark; Ron RayIntravascular catheter with guiding structure
US6010521 *25 Nov 19974 Ene 2000Advanced Cardiovasular Systems, Inc.Catheter member with bondable layer
US6013055 *13 Nov 199711 Ene 2000Boston Scientific CorporationCatheter balloon having selected folding characteristics
US6022359 *13 Ene 19998 Feb 2000Frantzen; John J.Stent delivery system featuring a flexible balloon
US6024722 *27 Dic 199415 Feb 2000Scimed Life Systems, Inc.Thermoplastic polyimide balloon catheter construction
US6030371 *22 Ago 199729 Feb 2000Pursley; Matt D.Catheters and method for nonextrusion manufacturing of catheters
US6039699 *22 Ene 199621 Mar 2000Cordis CorporationStiff catheter guidewire with flexible distal portion
US6048350 *14 Jun 199911 Abr 2000Scimed Life Systems, Inc.Segmented balloon delivery system
US6168571 *4 Ago 19992 Ene 2001Symbiosis CorporationLinear elastic member
US6179851 *15 Jun 199930 Ene 2001Scimed Life Systems, Inc.Guiding catheter for positioning a medical device within an artery
US6190332 *19 Feb 199820 Feb 2001Percusurge, Inc.Core wire with shapeable tip
US6193686 *30 Jun 199927 Feb 2001Advanced Cardiovascular Systems, Inc.Catheter with enhanced flexibility
US6213957 *22 Sep 199810 Abr 2001United States Surgical CorporationApparatus and method for removing tissue
US6217549 *8 Sep 199817 Abr 2001Lumend, Inc.Methods and apparatus for treating vascular occlusions
US6217567 *8 Oct 199917 Abr 2001Percusurge, Inc.Hollow medical wires and methods of constructing same
US6221006 *9 Feb 199924 Abr 2001Artemis Medical Inc.Entrapping apparatus and method for use
US6344029 *28 Nov 20005 Feb 2002Advanced Cardiovascular Systems, Inc.Catheter with enhanced flexibility
US6355016 *22 Feb 199912 Mar 2002Medtronic Percusurge, Inc.Catheter core wire
US6533754 *22 Nov 200018 Mar 2003Terumo Kabushiki KaishaCatheter
US6544224 *5 May 20008 Abr 2003Advanced Cardiovascular Systems, Inc.Lobed balloon catheter and method of use
US6544276 *27 Mar 19988 Abr 2003Medtronic Ave. Inc.Exchange method for emboli containment
US20020010489 *24 Jul 200124 Ene 2002Jeffrey GrayzelStiffened balloon catheter for dilatation and stenting
US20030032973 *10 Ago 200113 Feb 2003Matthew JenusaitisBalloon anchoring system
US20030040770 *23 Ago 200127 Feb 2003Radisch Herbert R.Segmented balloon catheter blade
US20040034384 *8 Ago 200219 Feb 2004Kohei FukayaExpansion catheter
US20050038383 *14 Ago 200317 Feb 2005Scimed Life Systems, Inc.Catheter having a cutting balloon including multiple cavities or multiple channels
USRE33561 *21 Dic 198826 Mar 1991E. I. Du Pont De Nemours And CompanyBalloon and manufacture thereof
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US768682430 Jul 200330 Mar 2010Angioscore, Inc.Apparatus and methods for treating hardened vascular lesions
US76911196 Nov 20026 Abr 2010Angioscore, Inc.Balloon catheter with non-deployable stent
US784205618 May 200730 Nov 2010Boston Scientific Scimed, Inc.Cutting member for bifurcation catheter assembly
US79316631 Dic 200526 Abr 2011Angioscore, Inc.Balloon catheter with non-deployable stent
US795535025 Mar 20047 Jun 2011Angioscore, Inc.Apparatus and methods for treating hardened vascular lesions
US796220825 Abr 200514 Jun 2011Cardiac Pacemakers, Inc.Method and apparatus for pacing during revascularization
US808002613 Ago 200420 Dic 2011Angioscore, Inc.Apparatus and methods for treating hardened vascular lesions
US821135418 May 20103 Jul 2012Cook Medical Technologies LlcBalloon with integral retention of a dilation element
US824435215 Jun 200914 Ago 2012Cardiac Pacemakers, Inc.Pacing catheter releasing conductive liquid
US845240023 May 201128 May 2013Cardiac Pacemakers, Inc.Method and apparatus for pacing during revascularization
US84546369 Nov 20114 Jun 2013Angioscore, Inc.Apparatus and methods for treating hardened vascular lesions
US845463718 Ene 20124 Jun 2013Cook Medical Technologies LlcScoring balloon with offset scoring elements
US845773815 Jun 20094 Jun 2013Cardiac Pacemakers, Inc.Pacing catheter for access to multiple vessels
US863935715 Jun 200928 Ene 2014Cardiac Pacemakers, Inc.Pacing catheter with stent electrode
US872166715 Mar 201313 May 2014Angioscore, Inc.Apparatus and methods for treating hardened vascular lesions
US88647436 Dic 201221 Oct 2014Angioscore, Inc.Methods and systems for delivering substances into luminal walls
US9017353 *20 Ene 201428 Abr 2015Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
US903723515 Jun 200919 May 2015Cardiac Pacemakers, Inc.Pacing catheter with expandable distal end
US909568818 Jun 20124 Ago 2015Cook Medical Technologies LlcBalloon with integral retention of a dilation element
US917397727 Sep 20123 Nov 2015Angioscore, Inc.Coating formulations for scoring or cutting balloon catheters
US9277935 *15 Nov 20138 Mar 2016Quadra Endovascular, Inc.Temporary vascular scaffold and scoring device
US935175627 Ago 201331 May 2016Angioscore, Inc.Method and system for treating valve stenosis
US936425415 May 201314 Jun 2016Angioscore, Inc.Method and system for treating valve stenosis
US937532826 Ene 201028 Jun 2016Angioscore, Inc.Balloon catheter with non-deployable stent
US940901215 Jun 20099 Ago 2016Cardiac Pacemakers, Inc.Pacemaker integrated with vascular intervention catheter
US941522515 Mar 201316 Ago 2016Cardiac Pacemakers, Inc.Method and apparatus for pacing during revascularization
US9480826 *18 Sep 20091 Nov 2016Cagent Vascular, LlcIntravascular device
US958603115 Mar 20137 Mar 2017Angioscore, Inc.Methods and systems for delivering substances into luminal walls
US9603619 *27 Mar 201528 Mar 2017Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
US9615848 *13 Sep 201211 Abr 2017John P. PigottIntravascular catheter having an expandable incising portion
US964949528 Oct 201516 May 2017Cardiac Pacemakers, Inc.Method and apparatus for pacing during revascularization
US20040143287 *30 Jul 200322 Jul 2004Angioscore, Inc.Apparatus and methods for treating hardened vascular lesions
US20050021070 *13 Ago 200427 Ene 2005Angioscore, Inc.Methods and apparatus for manipulating vascular prostheses
US20050049677 *6 Nov 20023 Mar 2005Farnan Robert C.Baloon catherter with non-deployable stent
US20060259005 *26 Abr 200616 Nov 2006Angioscore, Inc.Methods and systems for delivering substances into luminal walls
US20080077164 *29 Ago 200727 Mar 2008National University Of Ireland, GalwayMinimally Invasive Intravascular Treatment Device
US20080288041 *18 May 200720 Nov 2008Boston Scientific Scimed, Inc.Cutting Member for Bifurcation Catheter Assembly
US20090105687 *26 Sep 200823 Abr 2009Angioscore, Inc.Scoring catheter with drug delivery membrane
US20100042121 *18 Sep 200918 Feb 2010Peter SchneiderPre-angioplasty serration of atherosclerotic plaque enabling low-pressure balloon angioplasty and avoidance of stenting
US20100121372 *26 Ene 201013 May 2010Angioscore, Inc.Balloon catheter with non-deployable stent
US20100286593 *11 May 201011 Nov 2010Hotspur Technologies, Inc.Balloon catheter with cutting features and methods for use
US20110071559 *29 Nov 201024 Mar 2011Boston Scientific Scimed, Inc.Cutting Member for Bifurcation Catheter Assembly
US20110125247 *7 Feb 201126 May 2011Angioscore, Inc.Balloon catheter with non-deployable stent
US20130066346 *13 Sep 201214 Mar 2013John P. PigottIntravascular Catheter Having An Expandable Incising Portion
US20140128895 *20 Ene 20148 May 2014Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
US20140142598 *15 Nov 201322 May 2014Nfinium Vascular Technologies, LlcTemporary Vascular Scaffold and Scoring Device
US20140343590 *17 Sep 201220 Nov 2014Syntach AgDevice, And A Method For Treatment Of Increased Blood Pressure
US20150196319 *27 Mar 201516 Jul 2015Boston Scientific Scimed, Inc.Cutting balloon catheter having flexible atherotomes
WO2008144311A1 *13 May 200827 Nov 2008Boston Scientific Scimed, Inc.Cutting member for bifurcation catheter assembly
WO2009154730A1 *16 Jun 200923 Dic 2009Cardiac Pacemakers, Inc.Vascular intervention catheters with pacing electrodes
Clasificaciones
Clasificación de EE.UU.606/192
Clasificación internacionalA61F2/958, A61M29/00
Clasificación cooperativaA61B2017/22054, A61B2017/22061, A61M25/1002, A61M2025/1086, A61B2017/00778, A61B17/320725, A61B2017/22055
Clasificación europeaA61M25/10A, A61B17/3207E
Eventos legales
FechaCódigoEventoDescripción
10 Ago 2005ASAssignment
Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:O BRIEN, DENNIS;REEL/FRAME:016381/0371
Effective date: 20050201