US20060239482A1 - System and method for providing a waveform for stimulating biological tissue - Google Patents
System and method for providing a waveform for stimulating biological tissue Download PDFInfo
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- US20060239482A1 US20060239482A1 US11/404,476 US40447606A US2006239482A1 US 20060239482 A1 US20060239482 A1 US 20060239482A1 US 40447606 A US40447606 A US 40447606A US 2006239482 A1 US2006239482 A1 US 2006239482A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
- A61N1/37223—Circuits for electromagnetic coupling
- A61N1/37229—Shape or location of the implanted or external antenna
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
Definitions
- the present invention relates generally to a system and method for providing a waveform for stimulating biological tissue.
- each stimulator can be employed for performing spinal cord stimulation, deep-brain stimulation or for stimulation of other neurological paths, such as for treatment of various disorders and diseases.
- each stimulator includes a waveform generator that generates its own waveform.
- a user defines the necessary parameters and the stimulator constructs the waveform accordingly.
- the parameters include amplitude, frequency, phase symmetry and duty cycle. The more complex the waveform, the more parameters are necessary to describe the waveform.
- Implantable stimulators are constrained by space and typically cannot accommodate complex circuitry. Implantable stimulators, therefore, usually trade off waveform complexity for saving space. A simpler stimulator design also tends to consume less power, which is also a significant consideration in implantable devices. For example, power saving is important since surgery is usually required to replace the battery. Furthermore, simple stimulator designs are rugged and are generally less prone to failure. Safety and low failure rate are important requirements by the government regulator agencies for approving any medical device.
- the present invention relates generally to a system and method for providing a waveform for stimulating biological tissue.
- One embodiment of the present invention provides an implantable programmable stimulator system that includes memory that stores waveform data for at least one waveform.
- a playback system provides at least one output waveform based on the waveform data.
- the IPG includes memory that stores a waveform representation for each of a plurality of waveforms.
- a playback system is configured to retrieve at least one of the stored waveform representations from the memory and to provide at least one corresponding output waveform signal.
- At least one amplifier amplifies the corresponding output waveform signal to provide a corresponding amplified output waveform signal.
- Yet another embodiment provides a method for providing a waveform for stimulation of biological tissue.
- the method includes storing non-parametric waveform data corresponding to a plurality of recorded waveforms in memory located in an implantable pulse generator. At least one of the plurality of waveforms is retrieved from the memory. An output waveform is provided from playback circuitry located in the implantable pulse generator, the output waveform corresponding to the at least one of the plurality of waveforms retrieved from the memory.
- FIG. 1 depicts an example of a block diagram for a programmable stimulation system that can be implemented according to an aspect of the present invention.
- FIG. 2 depicts an example of yet another stimulation system that can be implemented according to an aspect of the present invention.
- FIG. 3 depicts an example of a stimulation system with external programming implemented according to an aspect of the present invention.
- the present invention relates to an implantable programmable stimulation system that can provide an output waveform, such as for use in stimulating biological tissue.
- the system includes memory that stores waveform data that represents one or more waveforms. The waveforms can be generated externally and provided to the memory.
- the system also includes a playback system, which can be similar to electronic digital or analog sound recording and playback devices.
- the playback system provides an output waveform based on the waveform data. For instance, one or more selected waveforms can be selected and played back via the playback system to provide an output waveform to an amplifier.
- the amplifier amplifies the output waveform (e.g., using voltage or current control) to stimulate the biological tissue electrically.
- the amplified output waveform can be provided to an electrode implanted at a location for delivering the electrical stimulus to targeted biological tissue (e.g., target sites within organs such as the heart and brain/spinal cord, for example.
- targeted biological tissue e.g., target sites within organs such as the heart and brain/spinal cord, for example.
- the output waveform can be adjusted or modified.
- FIG. 1 depicts a stimulation system 10 that can be implemented according to an aspect of the present invention.
- the stimulation system 10 includes memory 12 that stores (or records) waveform data corresponding to one or more waveforms.
- the waveform data can be preprogrammed, such as prior to implantation, or the waveform data can be programmed post-implantation of the system 10 .
- the waveform data can be stored in the memory 12 based on an INPUT signal received by a communication system 14 .
- the one or more waveforms can be stored as one or more complete periods of the waveform, which can be referred to as snippets.
- the waveform data that is stored in the memory 12 corresponds to one or more actual waveforms, which can be an analog or digital representation of the waveform(s). This type of waveform data that is stored in the memory 12 is referred to herein as non-parametric waveform data.
- the communication system 14 can include a receiver that receives the INPUT signal via one or more communication modes, such as including radio frequency (RF), infrared (IR), direct contact (e.g., electrically or optically conductive path), capacitive coupling, and inductive coupling to name a few.
- the INPUT signal further can be provided via more than one communication mode, such as providing the INPUT signal as including one or more waveforms via one mode and command information (e.g., scheduling and programming information) via another mode.
- the communication system 14 can be capable of bi-directional communications, such as also including a transmitter or transceiver circuitry. The transmitter and receiver portions of the communication system 14 can employ the same or different communication modes.
- the memory 12 can be implemented as an analog memory, such as is capable of storing an analog version of the waveform that is received by the communication system 14 .
- the memory can also be implemented as digital memory that stores a digital representation or sample of the input waveform or stores a digitally encoded version of the waveform.
- the memory 12 can store the sample waveform as a digital sample, such as using pulse code modulation (PCM) or adaptive differential pulse code modulation (ADPCM) or pulse width modulation (PWM), although other modulation techniques can be utilized.
- PCM pulse code modulation
- ADPCM adaptive differential pulse code modulation
- PWM pulse width modulation
- the digital sample of the waveform further may be stored in a compressed format according to one or more CODECs (e.g., MP3, AAC, 3GPP, WAV, etc.), although compression is not required.
- CODECs e.g., MP3, AAC, 3GPP, WAV, etc.
- Audio CODECs There are a multitude of varying standards that can be grouped in three major forms of audio CODECs, including, for example, direct audio coding, perceptual audio coding, and synthesis coding, any one or more of which can be employed to store a digital representation of waveforms in the memory 12 .
- a playback system 16 is configured to retrieve and play back one or more waveforms according to selected waveform data stored in the memory 12 .
- the playback system 16 can be implemented as hardware (e.g., one or more integrated circuits), software or a combination or hardware and software.
- the implementation of the playback system 16 can vary, for example, according to the type of audio (analog or digital) that is stored in the memory 12 .
- the playback system 16 for example, can be programmed with one or more audio CODECs that convert (or decode) the encoded waveform data into a corresponding output waveform.
- the playback system 16 can be implemented as an integrated circuit 24 , such as including a microcontroller or microprocessor.
- suitable microcontroller integrated circuits are commercially available from Atmel Corporation of San Jose, Calif.
- Such microcontroller ICs may include the memory 12 integrated into the IC 24 , such as in the form or FLASH memory or other programmable memory (electrically programmable read only memory (EPROM)), or the memory 12 can be external to the IC 24 .
- the playback system 16 provides the output waveform to an amplifier 18 that amplifies the output waveform.
- the playback system 16 further can be configured to provide output waveforms to one or more output channels, each output channel providing an amplified output waveform corresponding to the waveform data stored in the memory 12 .
- One or more electrodes 20 can be coupled to each of the channels for delivering electrical stimulation to biological tissue located adjacent the electrode(s).
- the playback system 16 can be configured to select one or more waveforms from the memory 12 for providing a corresponding output waveform.
- a plurality of different types of waveforms can be stored in the memory 12 , generally limited only by the size of the memory.
- the playback system 16 thus can select and arrange one or more waveforms to provide a desired output waveform pattern.
- the playback system 16 further can combine a plurality of different waveforms into more complex composite output waveforms. It will be appreciated that the ability of selecting from a plurality of predefined stored waveforms affords the stimulation system enhanced capabilities, as virtually any output waveform can be stored and played back from the memory 12 .
- the design can be simplified even further by storing waveforms of gradually changing parameters in the memory 12 .
- a plurality of versions of the same waveform, but of varying amplitude can be stored in the memory 12 so as to effectively eliminate the need for additional amplitude controlling circuitry. Accordingly, if a greater or lesser amplitude may be required for a given application, an appropriate different waveform can be selected.
- the playback system 16 can also be programmed and/or configured to manipulate one or more selected waveforms from the memory 12 , such as using digital or analog computation, to vary parameters (e.g., amplitude, frequency, phase symmetry and/or duty cycle) of the one or more selected waveforms.
- the corresponding amplified output signal corresponds to an amplified version of the selected waveform, including any such manipulations.
- the amplifier 18 can be implemented as an analog amplifier or a digital amplifier.
- a digital-to-analog converter (not shown) can provide a corresponding analog version of the output waveform and a linear amplifier can, in turn, operate to amplify the analog output waveform to a desired level.
- Power conditioning circuitry can be utilized to provide a desired potential for use in generating the amplified output waveform.
- the amplifier can be implemented as a class D amplifier (or switched power supply), although other amplifier topologies can also be used. By implementing the amplifier as a class D amplifier, the amplifier 18 can run directly off a battery or other power supply efficiently and be implemented using low-voltage components. Those skilled in the art will appreciate various types of switching amplifier topologies are that can be utilized in the system 10 . Additionally, the amplifier 18 can be configured to operate in a current mode or a voltage mode control, such as to provide a desired current or voltage.
- the amplifier 18 can comprise a network of amplifiers arranged to drive a plurality of loads (depicted as electrodes 20 ) according to respective output waveforms provided by the playback system 16 .
- the electrode(s) 20 can be implanted in strategic locations in the patient's tissue according to given application of the stimulation system 10 .
- the electrode(s) can be located within a patient's brain, spinal cord or other anatomic locations.
- the anatomic locations can be in close proximity to the playback system or at remote locations.
- the system 10 can be implemented as an open loop system or a closed loop system.
- the system 10 can also include feedback, indicated as dotted line 22 .
- the feedback 22 provides information about the stimulus being applied to the electrode(s) and/or about a characteristic of the electrode(s).
- the feedback 22 can provide an electrical signal to the playback system 16 , based on which an indication of load impedance associated with the electrode(s) can be determined.
- the impedance characteristics can be utilized for a variety of purposes.
- the impedance can be employed to implement current control, such as by the playback system 16 selecting a predefined waveform from the memory 12 to maintain a desired current level in the waveform that is provided to the electrode(s) 20 .
- the impedance characteristics can be used as part of diagnostics, such as by recording (or logging) impedance over extended periods of time and evaluating a condition of the electrode(s).
- the feedback 22 can be employed to ascertain high impedance conditions (e.g., an open circuit) or a low impedance condition (e.g., a short circuit).
- high impedance conditions e.g., an open circuit
- a low impedance condition e.g., a short circuit
- the system 10 can be implemented in a cost efficient manner from commercially available recording and playback circuitry. Additionally, because the waveforms can be generated externally, provided to the system 10 , and stored in the memory 12 , there is a greater degree of flexibility in the types and complexity of waveforms that can be stored in the memory. That is, the system 10 is not constrained by limitations in the cost or size or complexity of a typical parametric waveform generator. Additionally, the playback system 16 may further construct more complex waveforms by combining two or more stored waveforms in a particular order (e.g., a pattern of waveform trains).
- one or more of the waveforms stored in the memory can include actual recorded impulses (electrical waveforms), such as can be recorded from the patient in which the stimulation system 10 is to be implanted, from a different person or from a non-human animal subject.
- actual recorded impulses electrical waveforms
- FIG. 2 depicts an example of a programmable stimulation system 50 that can be implemented according to an aspect of the present invention.
- the system 50 comprises an implantable pulse generator (IPG) 52 that is implanted in a patient's body 54 , such as implanted under the skin of the chest (e.g., below the collarbone) or other anatomic location.
- IPG implantable pulse generator
- the IPG 52 is not required to generate a pulse or waveform, but instead is configured to play back one or more predefined waveforms.
- the IPG 52 includes an internal receiver 56 that can receive a signal from an external programmer 58 , which is located external to the body 54 .
- the external programmer 58 can communicate the signal to the receiver 56 using one or more communications modes, such as described herein.
- a connectionless communications mode is illustrated, although a physical connection can be made to provide an electrical or optical conductive medium for data communications.
- a waveform generator 60 can provide one or more waveforms 62 to the external programmer 58 for transmission to the IPG 52 .
- the waveform generator 60 can include any type of device or system that can generate the one or more waveforms 62 , including a programmable signal generator, a pulse generator, and a waveform synthesizer to name a few.
- the waveform generator 60 further may be a PC-based system or a stand alone system capable of generating one or more desired waveforms.
- the waveform generator 60 can also be programmed with biological, recorded waveforms, such as may have been measured and recorded from the patient's body 54 or from any other biological subject (e.g., human or other animal).
- the waveform can be recorded as electrical impulses measured from one or more anatomical regions of a biological subject's brain.
- the waveform generator 60 thus can provide the biological, recorded waveforms to the external programmer 58 .
- the external programmer 58 transmits a signal 59 to the receiver 56 of the IPG 52 corresponding to the waveform 62 provided by the generator 60 .
- the signal 59 transmitted by the external programmer 58 can include (or encode) the actual waveform 62 provided by the waveform generator 60 (e.g., an actual biological, recorded waveform or a synthesized waveform).
- the external programmer can transmit the signal 59 as including a complete period, more than one period (e.g., snippets) or as a fraction of a period of the desired waveform 62 in any communications mode.
- the receiver 56 for example, can provide the waveform to the memory as encoded waveform date, such as corresponding to an encoding scheme implemented by the waveform generator 60 .
- the receiver 56 can demodulate/decode an encoded received signal and provide a corresponding demodulated/decoded signal 66 to the memory 64 so that the waveform data corresponds to the one or more waveforms 62 . Additionally encoding may also be performed by the receiver 56 or other circuitry (not shown) for providing encoded waveform date for storing the waveform(s) 62 the memory 64 .
- the sample of the waveform 66 stored in the memory 64 can correspond to an analog version of the waveform or a corresponding digital (e.g., PCM) representation of the waveform.
- PCM digital
- Those skilled in the art will appreciate various different representations that can be stored in the memory 64 based on the teachings contained herein. It will further be understood that some or all of the waveforms 66 stored in the memory 64 can be programmed prior to implantation of the IPG 52 within the body 54 .
- playback circuitry 68 can play back one or more selected waveforms 66 from the memory 64 .
- the playback circuitry 68 can play back a waveform according to a defined play back schedule, which may be a periodic or continuous schedule.
- the playback circuitry 68 can be configured to play back on or more selected waveforms in response to a stimulus, which stimulus can be user-generated or provided by associated sensing circuitry (not shown.)
- the playback circuitry 68 can play back the one or more selected waveforms by retrieving the selected waveform(s) from the memory and providing the output waveform(s) to one or more amplifiers 70 .
- the amplifier 70 amplifies the output waveform to a desired level to provide a corresponding amplified version of the waveform. That is, the amplified waveform 72 can be substantially the same as the waveform 62 generated by the waveform generator 60 . Alternatively, when the waveform 62 is stored as encoded date, the amplified waveform 72 can correspond to a decoded version of the waveform. Typically, a plurality of waveforms 66 are stored in the memory 64 to provide a greater selection of available waveforms for operating the IPG 52 .
- the amplified waveform 72 can be provided to one or more strategically placed electrodes or other implantable devices capable of delivering an electrical stimulus to adjacent biological tissue.
- FIG. 3 depicts an example of part of a microprocessor based stimulation system 100 that can be implemented according to an aspect of the present invention.
- the system 100 includes a microcontroller 102 that is programmed and/or configured to control the system.
- the microcontroller 102 can communicate with an external device via a data bus 104 .
- the data bus 104 can provide for bi-directional communication relative to the microcontroller 102 .
- the communication my include input and/or output (I/O) data, such as provided by a communications system (e.g., a transmitter or receiver, not shown).
- the I/O data can be analog or digital data, as the microcontroller 102 includes an analog-to-digital converter 106 .
- the I/O data can include command data and waveform data.
- the command data can include scheduling information that controls operation of the system 100 .
- the scheduling information can identify which waveform(s) is to be played, how many times the waveform is to be played (e.g., a fixed number or continuously).
- the command data thus can be employed to program one or more registers or other types of memory with program instructions or operating parameters to control operation of the system 100 .
- the command data may also be utilized to enter a programming or learning mode, such as during which waveform data can be learned or programmed into the system 100 .
- the command data can also be provided as part of a diagnostic mode in which information about system operation can be obtained from the system 100 as output data.
- the waveform data can correspond to any number of one or more sample waveforms, which can be stored in memory 108 of the microcontroller 102 . While the memory 108 is depicted as being internal to the microcontroller 102 , the memory could be external to the microcontroller or be distributed partially within the microcontroller and partially external.
- the memory 108 can be implemented as programmable memory, such as including FLASH memory, EPROM or other memory types.
- the memory 108 and other components of the microcontroller 102 (as depicted in FIG. 3 ) can be accessed via an internal bus 110 .
- the microcontroller 102 included a timing and control block 112 that controls an oscillator 114 to provide a corresponding digital waveform to one or more associated port drivers 116 .
- the one or more port drivers 116 can receive more than one waveform (e.g., via a register 118 ) from the oscillator 114 , each of which corresponds to one or more waveforms selected from the memory 108 .
- the waveforms stored in the memory 108 are digital waveforms, such as can be encoded according to any desired CODEC.
- the one or more port drivers 116 provide a corresponding output waveform to an associated output stage 120 .
- Each output stage 120 can include a digital-to-analog converter and an amplifier that provides a respective amplified output waveform.
- N output stages are utilized to provide N corresponding amplified output waveforms, where N is a positive integer (N ⁇ 1).
- each of the output stages 120 includes a sigma delta demodulator 122 that demodulates the encoded data provided by the port drivers 116 and converts the digital representation to an analog signal.
- the waveforms stored in the memory 108 can be encoded as 1-bit sigma delta modulated signals, which allows for high resolution waveform reproduction with low noise without required digital compression. It is to be appreciated that other forms of demodulation, with or without compression, can also be utilized in the system 100 .
- Each demodulator 122 provides a corresponding demodulated, analog output signal to an associated amplified 124 .
- Each amplified 124 can drive an associated electrode with a corresponding amplified analog output signal (the amplified output signals indicated as being provided “to electrodes”).
- each output stage 120 can be configured to directly convert the digital output waveforms provided by the port drivers 116 to corresponding amplified analog signals.
- the port drivers 116 could provide the output waveforms as PCM or PWM output waveforms.
- the output stages can include associated amplifiers, such as implemented as class D or switching amplifiers, which convert the digital output waveforms to corresponding amplified analog output waveforms.
- switching amplifier topologies that could be implemented to provide a switching output signals based on such output waveforms.
- the averaged (or low-pass filtered) amplified output signal for each output stage represents a desired amplified output waveform.
- amplifier topologies that can be utilized in the system 100 of FIG. 3 (as well as in the other approaches of FIGS. 1 and 2 ).
- the system 100 can also employ feedback 130 for use in impedance determination and charge balancing using the techniques mentioned herein.
- the feedback 130 can include an analog indication of electrode voltages, which are provided to the ADC 106 of the microcontroller 102 and converted to corresponding digital signals.
- the microcontroller 102 thus can employ the signals provided by the feedback information provided by the ADC to implement desired controls (e.g., voltage control or current control) or to implement diagnostic functions, such as described herein.
- Various feedback-schemes can be utilized to measure impedance characteristics of a load (e.g., electrode) that is associated with each of the respective output stages 120 .
- the impedance characteristics can be described according to a model of an implanted electrode, such as may describe an electrode-electrolyte interface that is expressed as a serial capacitance and a serial resistance, together with a Faradic resistance in parallel with the series resistance and capacitance.
- the feedback scheme can be configured to measure the electrode model parameters in real time.
- Possible feedback schemes that could be implemented include a positive feedback scheme, a current interrupt scheme or continuous impedance measurement using small signal injections of multi-sinusoidal waveforms. Those skilled in the art will understand and appreciate various types of feedback schemes that can be utilized in accordance with the present invention.
Abstract
An implantable programmable stimulator system that includes memory that stores waveform data for at least on waveform. A playback system provides at least one output waveform based on the waveform data.
Description
- This application claims the benefit of U.S. Provisional Patent Application No. 60/671,011, which was filed Apr. 13, 2005, and entitled SYSTEM AND METHOD FOR PROVIDING A WAVEFORM FOR STIMULATING BIOLOGICAL TISSUE, the entire contents of which is incorporated herein by reference.
- The present invention relates generally to a system and method for providing a waveform for stimulating biological tissue.
- Various types of stimulators have been developed for a variety of in-vivo applications. For example, a stimulator can be employed for performing spinal cord stimulation, deep-brain stimulation or for stimulation of other neurological paths, such as for treatment of various disorders and diseases. Typically, each stimulator includes a waveform generator that generates its own waveform. For instance, a user defines the necessary parameters and the stimulator constructs the waveform accordingly. Usually the parameters include amplitude, frequency, phase symmetry and duty cycle. The more complex the waveform, the more parameters are necessary to describe the waveform.
- Implantable stimulators are constrained by space and typically cannot accommodate complex circuitry. Implantable stimulators, therefore, usually trade off waveform complexity for saving space. A simpler stimulator design also tends to consume less power, which is also a significant consideration in implantable devices. For example, power saving is important since surgery is usually required to replace the battery. Furthermore, simple stimulator designs are rugged and are generally less prone to failure. Safety and low failure rate are important requirements by the government regulator agencies for approving any medical device.
- The present invention relates generally to a system and method for providing a waveform for stimulating biological tissue.
- One embodiment of the present invention provides an implantable programmable stimulator system that includes memory that stores waveform data for at least one waveform. A playback system provides at least one output waveform based on the waveform data.
- Another embodiment of the present invention provides an implantable pulse generator (IPG). The IPG includes memory that stores a waveform representation for each of a plurality of waveforms. A playback system is configured to retrieve at least one of the stored waveform representations from the memory and to provide at least one corresponding output waveform signal. At least one amplifier amplifies the corresponding output waveform signal to provide a corresponding amplified output waveform signal.
- Yet another embodiment provides a method for providing a waveform for stimulation of biological tissue. The method includes storing non-parametric waveform data corresponding to a plurality of recorded waveforms in memory located in an implantable pulse generator. At least one of the plurality of waveforms is retrieved from the memory. An output waveform is provided from playback circuitry located in the implantable pulse generator, the output waveform corresponding to the at least one of the plurality of waveforms retrieved from the memory.
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FIG. 1 depicts an example of a block diagram for a programmable stimulation system that can be implemented according to an aspect of the present invention. -
FIG. 2 depicts an example of yet another stimulation system that can be implemented according to an aspect of the present invention. -
FIG. 3 depicts an example of a stimulation system with external programming implemented according to an aspect of the present invention. - The present invention relates to an implantable programmable stimulation system that can provide an output waveform, such as for use in stimulating biological tissue. The system includes memory that stores waveform data that represents one or more waveforms. The waveforms can be generated externally and provided to the memory. The system also includes a playback system, which can be similar to electronic digital or analog sound recording and playback devices. The playback system provides an output waveform based on the waveform data. For instance, one or more selected waveforms can be selected and played back via the playback system to provide an output waveform to an amplifier. The amplifier amplifies the output waveform (e.g., using voltage or current control) to stimulate the biological tissue electrically. For example, the amplified output waveform can be provided to an electrode implanted at a location for delivering the electrical stimulus to targeted biological tissue (e.g., target sites within organs such as the heart and brain/spinal cord, for example. The output waveform can be adjusted or modified.
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FIG. 1 depicts astimulation system 10 that can be implemented according to an aspect of the present invention. Thestimulation system 10 includesmemory 12 that stores (or records) waveform data corresponding to one or more waveforms. The waveform data can be preprogrammed, such as prior to implantation, or the waveform data can be programmed post-implantation of thesystem 10. The waveform data can be stored in thememory 12 based on an INPUT signal received by acommunication system 14. The one or more waveforms can be stored as one or more complete periods of the waveform, which can be referred to as snippets. As described herein, the waveform data that is stored in thememory 12 corresponds to one or more actual waveforms, which can be an analog or digital representation of the waveform(s). This type of waveform data that is stored in thememory 12 is referred to herein as non-parametric waveform data. - The
communication system 14 can include a receiver that receives the INPUT signal via one or more communication modes, such as including radio frequency (RF), infrared (IR), direct contact (e.g., electrically or optically conductive path), capacitive coupling, and inductive coupling to name a few. The INPUT signal further can be provided via more than one communication mode, such as providing the INPUT signal as including one or more waveforms via one mode and command information (e.g., scheduling and programming information) via another mode. Thecommunication system 14 can be capable of bi-directional communications, such as also including a transmitter or transceiver circuitry. The transmitter and receiver portions of thecommunication system 14 can employ the same or different communication modes. - The
memory 12 can be implemented as an analog memory, such as is capable of storing an analog version of the waveform that is received by thecommunication system 14. The memory can also be implemented as digital memory that stores a digital representation or sample of the input waveform or stores a digitally encoded version of the waveform. For instance, thememory 12 can store the sample waveform as a digital sample, such as using pulse code modulation (PCM) or adaptive differential pulse code modulation (ADPCM) or pulse width modulation (PWM), although other modulation techniques can be utilized. The digital sample of the waveform further may be stored in a compressed format according to one or more CODECs (e.g., MP3, AAC, 3GPP, WAV, etc.), although compression is not required. There are a multitude of varying standards that can be grouped in three major forms of audio CODECs, including, for example, direct audio coding, perceptual audio coding, and synthesis coding, any one or more of which can be employed to store a digital representation of waveforms in thememory 12. - A
playback system 16 is configured to retrieve and play back one or more waveforms according to selected waveform data stored in thememory 12. Theplayback system 16 can be implemented as hardware (e.g., one or more integrated circuits), software or a combination or hardware and software. The implementation of theplayback system 16 can vary, for example, according to the type of audio (analog or digital) that is stored in thememory 12. Theplayback system 16, for example, can be programmed with one or more audio CODECs that convert (or decode) the encoded waveform data into a corresponding output waveform. - The
playback system 16 can be implemented as anintegrated circuit 24, such as including a microcontroller or microprocessor. For instance, suitable microcontroller integrated circuits (ICs) are commercially available from Atmel Corporation of San Jose, Calif. Such microcontroller ICs may include thememory 12 integrated into theIC 24, such as in the form or FLASH memory or other programmable memory (electrically programmable read only memory (EPROM)), or thememory 12 can be external to theIC 24. - The
playback system 16 provides the output waveform to anamplifier 18 that amplifies the output waveform. Theplayback system 16 further can be configured to provide output waveforms to one or more output channels, each output channel providing an amplified output waveform corresponding to the waveform data stored in thememory 12. One ormore electrodes 20 can be coupled to each of the channels for delivering electrical stimulation to biological tissue located adjacent the electrode(s). - As an example, the
playback system 16 can be configured to select one or more waveforms from thememory 12 for providing a corresponding output waveform. As mentioned above, a plurality of different types of waveforms can be stored in thememory 12, generally limited only by the size of the memory. Theplayback system 16 thus can select and arrange one or more waveforms to provide a desired output waveform pattern. Additionally, theplayback system 16 further can combine a plurality of different waveforms into more complex composite output waveforms. It will be appreciated that the ability of selecting from a plurality of predefined stored waveforms affords the stimulation system enhanced capabilities, as virtually any output waveform can be stored and played back from thememory 12. - The design can be simplified even further by storing waveforms of gradually changing parameters in the
memory 12. For example, a plurality of versions of the same waveform, but of varying amplitude, can be stored in thememory 12 so as to effectively eliminate the need for additional amplitude controlling circuitry. Accordingly, if a greater or lesser amplitude may be required for a given application, an appropriate different waveform can be selected. Theplayback system 16 can also be programmed and/or configured to manipulate one or more selected waveforms from thememory 12, such as using digital or analog computation, to vary parameters (e.g., amplitude, frequency, phase symmetry and/or duty cycle) of the one or more selected waveforms. The corresponding amplified output signal corresponds to an amplified version of the selected waveform, including any such manipulations. - The
amplifier 18 can be implemented as an analog amplifier or a digital amplifier. For an analog version of theamplifier 18, a digital-to-analog converter (not shown) can provide a corresponding analog version of the output waveform and a linear amplifier can, in turn, operate to amplify the analog output waveform to a desired level. Power conditioning circuitry can be utilized to provide a desired potential for use in generating the amplified output waveform. Alternatively, the amplifier can be implemented as a class D amplifier (or switched power supply), although other amplifier topologies can also be used. By implementing the amplifier as a class D amplifier, theamplifier 18 can run directly off a battery or other power supply efficiently and be implemented using low-voltage components. Those skilled in the art will appreciate various types of switching amplifier topologies are that can be utilized in thesystem 10. Additionally, theamplifier 18 can be configured to operate in a current mode or a voltage mode control, such as to provide a desired current or voltage. - The
amplifier 18 can comprise a network of amplifiers arranged to drive a plurality of loads (depicted as electrodes 20) according to respective output waveforms provided by theplayback system 16. The electrode(s) 20 can be implanted in strategic locations in the patient's tissue according to given application of thestimulation system 10. For example, the electrode(s) can be located within a patient's brain, spinal cord or other anatomic locations. The anatomic locations can be in close proximity to the playback system or at remote locations. - The
system 10 can be implemented as an open loop system or a closed loop system. For the example of a closed loop system, thesystem 10 can also include feedback, indicated as dottedline 22. Thefeedback 22 provides information about the stimulus being applied to the electrode(s) and/or about a characteristic of the electrode(s). As an example, thefeedback 22 can provide an electrical signal to theplayback system 16, based on which an indication of load impedance associated with the electrode(s) can be determined. - The impedance characteristics can be utilized for a variety of purposes. For instance, the impedance can be employed to implement current control, such as by the
playback system 16 selecting a predefined waveform from thememory 12 to maintain a desired current level in the waveform that is provided to the electrode(s) 20. Alternatively or additionally, the impedance characteristics can be used as part of diagnostics, such as by recording (or logging) impedance over extended periods of time and evaluating a condition of the electrode(s). As another alternative, thefeedback 22 can be employed to ascertain high impedance conditions (e.g., an open circuit) or a low impedance condition (e.g., a short circuit). Those skilled in the art will understand and appreciate various approaches that can be implemented to provide thefeedback 22. Additionally, various types of diagnostic or operational controls can be implemented based on such feedback. - Since the waveform is played back from non-parametric waveform data that is stored in the
memory 12, thesystem 10 can be implemented in a cost efficient manner from commercially available recording and playback circuitry. Additionally, because the waveforms can be generated externally, provided to thesystem 10, and stored in thememory 12, there is a greater degree of flexibility in the types and complexity of waveforms that can be stored in the memory. That is, thesystem 10 is not constrained by limitations in the cost or size or complexity of a typical parametric waveform generator. Additionally, theplayback system 16 may further construct more complex waveforms by combining two or more stored waveforms in a particular order (e.g., a pattern of waveform trains). As an example, one or more of the waveforms stored in the memory can include actual recorded impulses (electrical waveforms), such as can be recorded from the patient in which thestimulation system 10 is to be implanted, from a different person or from a non-human animal subject. -
FIG. 2 depicts an example of a programmable stimulation system 50 that can be implemented according to an aspect of the present invention. The system 50 comprises an implantable pulse generator (IPG) 52 that is implanted in a patient'sbody 54, such as implanted under the skin of the chest (e.g., below the collarbone) or other anatomic location. In contrast to many existing IPG designs, the IPG 52 is not required to generate a pulse or waveform, but instead is configured to play back one or more predefined waveforms. The IPG 52 includes aninternal receiver 56 that can receive a signal from anexternal programmer 58, which is located external to thebody 54. Theexternal programmer 58 can communicate the signal to thereceiver 56 using one or more communications modes, such as described herein. In the example, ofFIG. 2 , a connectionless communications mode is illustrated, although a physical connection can be made to provide an electrical or optical conductive medium for data communications. - A
waveform generator 60 can provide one ormore waveforms 62 to theexternal programmer 58 for transmission to the IPG 52. Thewaveform generator 60 can include any type of device or system that can generate the one ormore waveforms 62, including a programmable signal generator, a pulse generator, and a waveform synthesizer to name a few. Thewaveform generator 60 further may be a PC-based system or a stand alone system capable of generating one or more desired waveforms. Thewaveform generator 60 can also be programmed with biological, recorded waveforms, such as may have been measured and recorded from the patient'sbody 54 or from any other biological subject (e.g., human or other animal). For electrical stimulation of the patient's brain, the waveform can be recorded as electrical impulses measured from one or more anatomical regions of a biological subject's brain. Thewaveform generator 60 thus can provide the biological, recorded waveforms to theexternal programmer 58. - The
external programmer 58 transmits asignal 59 to thereceiver 56 of the IPG 52 corresponding to thewaveform 62 provided by thegenerator 60. As discussed herein, thesignal 59 transmitted by theexternal programmer 58 can include (or encode) theactual waveform 62 provided by the waveform generator 60 (e.g., an actual biological, recorded waveform or a synthesized waveform). The external programmer can transmit thesignal 59 as including a complete period, more than one period (e.g., snippets) or as a fraction of a period of the desiredwaveform 62 in any communications mode. Thereceiver 56, for example, can provide the waveform to the memory as encoded waveform date, such as corresponding to an encoding scheme implemented by thewaveform generator 60. Alternatively, thereceiver 56 can demodulate/decode an encoded received signal and provide a corresponding demodulated/decodedsignal 66 to thememory 64 so that the waveform data corresponds to the one ormore waveforms 62. Additionally encoding may also be performed by thereceiver 56 or other circuitry (not shown) for providing encoded waveform date for storing the waveform(s) 62 thememory 64. - The sample of the
waveform 66 stored in thememory 64 can correspond to an analog version of the waveform or a corresponding digital (e.g., PCM) representation of the waveform. Those skilled in the art will appreciate various different representations that can be stored in thememory 64 based on the teachings contained herein. It will further be understood that some or all of thewaveforms 66 stored in thememory 64 can be programmed prior to implantation of the IPG 52 within thebody 54. - After a desired number of one or
more waveforms 66 have been stored in thememory 64, such as during a program mode,playback circuitry 68 can play back one or more selectedwaveforms 66 from thememory 64. Theplayback circuitry 68 can play back a waveform according to a defined play back schedule, which may be a periodic or continuous schedule. Alternatively or additionally, theplayback circuitry 68 can be configured to play back on or more selected waveforms in response to a stimulus, which stimulus can be user-generated or provided by associated sensing circuitry (not shown.) - The
playback circuitry 68 can play back the one or more selected waveforms by retrieving the selected waveform(s) from the memory and providing the output waveform(s) to one ormore amplifiers 70. Theamplifier 70 amplifies the output waveform to a desired level to provide a corresponding amplified version of the waveform. That is, the amplifiedwaveform 72 can be substantially the same as thewaveform 62 generated by thewaveform generator 60. Alternatively, when thewaveform 62 is stored as encoded date, the amplifiedwaveform 72 can correspond to a decoded version of the waveform. Typically, a plurality ofwaveforms 66 are stored in thememory 64 to provide a greater selection of available waveforms for operating the IPG 52. The amplifiedwaveform 72 can be provided to one or more strategically placed electrodes or other implantable devices capable of delivering an electrical stimulus to adjacent biological tissue. -
FIG. 3 depicts an example of part of a microprocessor basedstimulation system 100 that can be implemented according to an aspect of the present invention. Thesystem 100 includes a microcontroller 102 that is programmed and/or configured to control the system. The microcontroller 102 can communicate with an external device via adata bus 104. Thedata bus 104 can provide for bi-directional communication relative to the microcontroller 102. The communication my include input and/or output (I/O) data, such as provided by a communications system (e.g., a transmitter or receiver, not shown). The I/O data can be analog or digital data, as the microcontroller 102 includes an analog-to-digital converter 106. - By way of example, the I/O data can include command data and waveform data. The command data can include scheduling information that controls operation of the
system 100. For instance, the scheduling information can identify which waveform(s) is to be played, how many times the waveform is to be played (e.g., a fixed number or continuously). The command data thus can be employed to program one or more registers or other types of memory with program instructions or operating parameters to control operation of thesystem 100. The command data may also be utilized to enter a programming or learning mode, such as during which waveform data can be learned or programmed into thesystem 100. The command data can also be provided as part of a diagnostic mode in which information about system operation can be obtained from thesystem 100 as output data. - The waveform data can correspond to any number of one or more sample waveforms, which can be stored in
memory 108 of the microcontroller 102. While thememory 108 is depicted as being internal to the microcontroller 102, the memory could be external to the microcontroller or be distributed partially within the microcontroller and partially external. Thememory 108 can be implemented as programmable memory, such as including FLASH memory, EPROM or other memory types. Thememory 108 and other components of the microcontroller 102 (as depicted inFIG. 3 ) can be accessed via aninternal bus 110. - The microcontroller 102 included a timing and control block 112 that controls an
oscillator 114 to provide a corresponding digital waveform to one or more associated port drivers 116. The one or more port drivers 116 can receive more than one waveform (e.g., via a register 118) from theoscillator 114, each of which corresponds to one or more waveforms selected from thememory 108. In the example ofFIG. 3 , it is assumed that the waveforms stored in thememory 108 are digital waveforms, such as can be encoded according to any desired CODEC. The one or more port drivers 116 provide a corresponding output waveform to an associatedoutput stage 120. - Each
output stage 120 can include a digital-to-analog converter and an amplifier that provides a respective amplified output waveform. N output stages are utilized to provide N corresponding amplified output waveforms, where N is a positive integer (N≧1). In the example ofFIG. 3 , each of the output stages 120 includes asigma delta demodulator 122 that demodulates the encoded data provided by the port drivers 116 and converts the digital representation to an analog signal. For instance, the waveforms stored in thememory 108 can be encoded as 1-bit sigma delta modulated signals, which allows for high resolution waveform reproduction with low noise without required digital compression. It is to be appreciated that other forms of demodulation, with or without compression, can also be utilized in thesystem 100. Eachdemodulator 122 provides a corresponding demodulated, analog output signal to an associated amplified 124. Each amplified 124 can drive an associated electrode with a corresponding amplified analog output signal (the amplified output signals indicated as being provided “to electrodes”). - As an alternative, each
output stage 120 can be configured to directly convert the digital output waveforms provided by the port drivers 116 to corresponding amplified analog signals. For example, the port drivers 116 could provide the output waveforms as PCM or PWM output waveforms. The output stages can include associated amplifiers, such as implemented as class D or switching amplifiers, which convert the digital output waveforms to corresponding amplified analog output waveforms. Those skilled in the art will understand and appreciate various types of switching amplifier topologies that could be implemented to provide a switching output signals based on such output waveforms. Thus, the averaged (or low-pass filtered) amplified output signal for each output stage represents a desired amplified output waveform. Those skilled in the art will understand and appreciate various possible amplifier topologies that can be utilized in thesystem 100 ofFIG. 3 (as well as in the other approaches ofFIGS. 1 and 2 ). - The
system 100 can also employfeedback 130 for use in impedance determination and charge balancing using the techniques mentioned herein. For example, thefeedback 130 can include an analog indication of electrode voltages, which are provided to theADC 106 of the microcontroller 102 and converted to corresponding digital signals. The microcontroller 102 thus can employ the signals provided by the feedback information provided by the ADC to implement desired controls (e.g., voltage control or current control) or to implement diagnostic functions, such as described herein. - Various feedback-schemes can be utilized to measure impedance characteristics of a load (e.g., electrode) that is associated with each of the respective output stages 120. The impedance characteristics can be described according to a model of an implanted electrode, such as may describe an electrode-electrolyte interface that is expressed as a serial capacitance and a serial resistance, together with a Faradic resistance in parallel with the series resistance and capacitance. Thus, the feedback scheme can be configured to measure the electrode model parameters in real time. Possible feedback schemes that could be implemented include a positive feedback scheme, a current interrupt scheme or continuous impedance measurement using small signal injections of multi-sinusoidal waveforms. Those skilled in the art will understand and appreciate various types of feedback schemes that can be utilized in accordance with the present invention.
- What have been described above are examples of the present invention. It is, of course, not possible to describe every conceivable combination of components or methodologies for purposes of describing the present invention, but one of ordinary skill in the art will recognize that many further combinations and permutations of the present invention are possible. Accordingly, the present invention is intended to embrace all such alterations, modifications, and variations that fall within the spirit and scope of the appended claims.
Claims (36)
1. An implantable programmable stimulator system comprising:
memory that stores waveform data for at least one waveform; and
a playback system that provides at least one output waveform based on the waveform data.
2. The system of claim 1 , wherein the waveform data comprises non-parametric waveform data corresponding to at least a fraction of a period of the at least one waveform.
3. The system of claim 1 , wherein the waveform data further comprises waveform data for a plurality of different waveforms, the playback system providing the output waveform based on the waveform data selected for at least one of the plurality of different waveforms.
4. The system of claim 3 , wherein the playback system is configured to construct the output waveform by combining at least two of the plurality of different waveforms stored in the memory.
5. The system of claim 1 , wherein the waveform data is encoded according to a CODEC, the playback system being operative to decode the waveform data according to the CODEC to provide the output waveform.
6. The system of claim 1 , further comprising an amplifier that provides an amplified output signal corresponding to the output waveform.
7. The system of claim 6 , wherein the amplifier comprises a switching amplifier that provides the amplified output signal as a pulse-width-modulated signal.
8. The system of claim 6 , further comprising at least one electrode that emits an electrical stimulation signal having desired waveform characteristics according to the amplified output signal.
9. The system of claim 8 , further comprising feedback from an output of the amplifier to the playback system; the feedback providing the playback system with information about at least one of the electrical stimulation signal emitted by the at least one electrode or a characteristic of the electrode.
10. The system of claim 1 , wherein the playback system is at least one of programmed and configured to manipulate the output waveform to vary at least one parameter of the output waveform.
11. The system of claim 1 , further comprising a receiver that receives an input signal that comprises the at least one waveform, the waveform data being stored in the memory according to the input signal to enable the playback system to provide the output waveform with a least a portion of the at least one waveform.
12. The system of claim 11 , further comprising an external transmitter that provides the input signal according to at least one communication mode.
13. The system of claim 12 , further comprising a waveform generator that provides the external transmitter with the at least one waveform, the external transmitter providing the input signal to program the memory with the waveform data for the at least one waveform.
14. The system of claim 13 , wherein the waveform generator is programmed with at least one biological recorded waveform, the waveform generator providing the at least one biological recorded waveform to the external transmitter, the input signal provided by the external transmitter comprising the at least one biological recorded waveform.
15. The system of claim 12 , wherein the memory and the playback system form part of a single integrated circuit that is separate from the external transmitter.
16. The system of claim 1 , wherein the playback system is configured to provide at least one selected waveform from the memory according to a defined schedule.
17. The system of claim 1 , wherein the playback system is configured to provide at least one of selected waveform from the memory in response to a stimulus.
18. The system of claim 1 , wherein the memory stores waveform data for a plurality of waveforms, at least one of the plurality waveforms comprising a biological waveform recorded from a biological subject.
19. An implantable pulse generator, comprising:
memory that stores a waveform representation for each of a plurality of waveforms; and
a playback system configured to retrieve at least one of the stored waveform representations from the memory and to provide at least one corresponding output waveform signal; and
at least one amplifier that amplifies the at least one corresponding output waveform signal to provide at least one corresponding amplified output waveform signal.
20. The implantable pulse generator of claim 19 , further comprising a receiver that receives a signal corresponding to at least one waveform according to a predetermined communication mode, the memory storing at least some of the stored waveform representations based on the signal received by the receiver.
21. The implantable pulse generator of claim 19 , wherein the playback system is configured to retrieve and play back at least one selected waveform from the memory in response to a stimulus, such that the output waveform signal provided by the playback system comprises the at least one selected waveform.
22. The implantable pulse generator of claim 19 , wherein the playback system is configured to retrieve and play back at least one selected waveform from the memory according to a schedule, such that the output waveform signal provided by the playback system comprises the at least one selected waveform.
23. The implantable pulse generator of claim 19 , wherein the memory and the playback system form part of a single integrated circuit.
24. The implantable pulse generator of claim 19 , further comprises at least one electrode that is electrically connected with the at least one amplifier, the at least one electrode emitting an electrical stimulation signal having waveform characteristics according to the corresponding amplified output waveform signal.
25. The implantable pulse generator of claim 24 , further comprising feedback connected to provide the playback system with information about at least one of the electrical stimulation signal emitted by the at least one electrode or a characteristic of the electrode.
26. The implantable pulse generator of claim 19 , wherein the playback system is configured to construct the at least one corresponding output waveform signal by combining at least two of the plurality of waveform representations stored in the memory.
27. The implantable pulse generator of claim 19 , wherein the playback system is at least one of programmed and configured to manipulate at least one of the plurality of waveforms is retrieved from the memory so as to vary at least one parameter of the corresponding output waveform signal.
28. The implantable pulse generator of claim 18 , further comprising a receiver that receives an input signal that is provided according to at least one communication mode, at least one waveform representation being stored in the memory according to the input signal.
29. The implantable pulse generator of claim 28 , further comprising an external transmitter that provides the input signal according to the at least one communication mode.
30. The implantable pulse generator of claim 29 , further comprising a waveform generator that provides the external transmitter with at least one of the plurality of waveforms, the external transmitter providing the input signal to program the memory with the waveform representation for the at least one of the plurality of waveforms provided by the waveform generator.
31. The implantable pulse generator of claim 30 , wherein the waveform generator is programmed with waveforms recorded from a biological subject, the at least one of the plurality of waveforms provided by the waveform generator comprising at least one of the biological recorded waveforms.
32. The implantable pulse generator of claim 19 , wherein the memory stores a plurality of waveforms, at least one of the plurality waveforms stored in the memory comprising a biological waveform recorded from a biological subject.
33. The implantable pulse generator of claim 19 , wherein the plurality waveforms are stored in the memory as digital data and the playback system provides the at corresponding output waveform signal as a digital output waveform signal, the implantable pulse generator further comprising a digital-to-analog converter that converts the digital output waveform signal to a corresponding analog output waveform signal, the amplifier comprising analog amplifier that amplifies the analog output waveform signal to provide the at least one corresponding amplified output waveform signal.
34. A method for providing a waveform for stimulation of biological tissue, the method comprising:
storing non-parametric waveform data corresponding to a plurality of recorded waveforms in memory located in an implantable pulse generator;
retrieving at least one of the plurality of waveforms from the memory; and
providing an output waveform from playback circuitry located in the implantable pulse generator, the output waveform corresponding to the at least one of the plurality of waveforms retrieved from the memory.
35. The method of claim 34 , further comprising:
implanting the implantable pulse generator in a patient's body, at least one electrode connected to receive the output waveform, the at least one electrode delivering at least one electrical stimulus to targeted biological tissue with waveform characteristics according to the output waveform provided from the playback circuitry.
36. The method of claim 34 , wherein the at least one waveform that is retrieved from memory includes at least one waveform recorded from a biological subject.
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Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070000372A1 (en) * | 2005-04-13 | 2007-01-04 | The Cleveland Clinic Foundation | System and method for providing a waveform for stimulating biological tissue |
CN102421477A (en) * | 2009-04-24 | 2012-04-18 | 康尔福盛2200公司 | Cortical stimulator method and apparatus |
US9101769B2 (en) | 2011-01-03 | 2015-08-11 | The Regents Of The University Of California | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
US9211408B2 (en) | 2005-04-13 | 2015-12-15 | The Cleveland Clinic Foundation | System and method for neuromodulation using composite patterns of stimulation or waveforms |
US20160022992A1 (en) * | 2014-07-25 | 2016-01-28 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
US9339650B2 (en) | 2005-04-13 | 2016-05-17 | The Cleveland Clinic Foundation | Systems and methods for neuromodulation using pre-recorded waveforms |
US9393409B2 (en) | 2011-11-11 | 2016-07-19 | Neuroenabling Technologies, Inc. | Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function |
US9409023B2 (en) | 2011-03-24 | 2016-08-09 | California Institute Of Technology | Spinal stimulator systems for restoration of function |
US9409011B2 (en) | 2011-01-21 | 2016-08-09 | California Institute Of Technology | Method of constructing an implantable microelectrode array |
US9415218B2 (en) | 2011-11-11 | 2016-08-16 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
US9717627B2 (en) | 2013-03-12 | 2017-08-01 | Oculeve, Inc. | Implant delivery devices, systems, and methods |
US9737702B2 (en) | 2013-04-19 | 2017-08-22 | Oculeve, Inc. | Nasal stimulation devices and methods |
US9737712B2 (en) | 2014-10-22 | 2017-08-22 | Oculeve, Inc. | Stimulation devices and methods for treating dry eye |
US9764150B2 (en) | 2014-10-22 | 2017-09-19 | Oculeve, Inc. | Contact lens for increasing tear production |
US9770583B2 (en) | 2014-02-25 | 2017-09-26 | Oculeve, Inc. | Polymer formulations for nasolacrimal stimulation |
US20170312519A1 (en) * | 2015-10-27 | 2017-11-02 | Hrl Laboratories, Llc | Transcranial control of procedural memory reconsolidation for skill acquisition |
US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
US9993642B2 (en) | 2013-03-15 | 2018-06-12 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
US10092750B2 (en) | 2011-11-11 | 2018-10-09 | Neuroenabling Technologies, Inc. | Transcutaneous neuromodulation system and methods of using same |
US10137299B2 (en) | 2013-09-27 | 2018-11-27 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
US10143846B2 (en) | 2010-11-16 | 2018-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for treatment of dry eye |
CN109157209A (en) * | 2018-10-25 | 2019-01-08 | 江南大学 | A kind of compressed sensing based processing of bioelectric signals circuit and method |
US10207108B2 (en) | 2014-10-22 | 2019-02-19 | Oculeve, Inc. | Implantable nasal stimulator systems and methods |
US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
US10426958B2 (en) | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
US10610095B2 (en) | 2016-12-02 | 2020-04-07 | Oculeve, Inc. | Apparatus and method for dry eye forecast and treatment recommendation |
US10646164B1 (en) * | 2016-05-24 | 2020-05-12 | Stimwave Technologies Incorporated | Pulse-density modulation to synthesize stimulation waveforms on an implantable device |
US10751533B2 (en) | 2014-08-21 | 2020-08-25 | The Regents Of The University Of California | Regulation of autonomic control of bladder voiding after a complete spinal cord injury |
US10773074B2 (en) | 2014-08-27 | 2020-09-15 | The Regents Of The University Of California | Multi-electrode array for spinal cord epidural stimulation |
US10786673B2 (en) | 2014-01-13 | 2020-09-29 | California Institute Of Technology | Neuromodulation systems and methods of using same |
US10918864B2 (en) | 2016-05-02 | 2021-02-16 | Oculeve, Inc. | Intranasal stimulation for treatment of meibomian gland disease and blepharitis |
US11097122B2 (en) | 2015-11-04 | 2021-08-24 | The Regents Of The University Of California | Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel |
US11273283B2 (en) | 2017-12-31 | 2022-03-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
US11298533B2 (en) | 2015-08-26 | 2022-04-12 | The Regents Of The University Of California | Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject |
US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
US11452839B2 (en) | 2018-09-14 | 2022-09-27 | Neuroenhancement Lab, LLC | System and method of improving sleep |
US11484718B2 (en) | 2021-01-22 | 2022-11-01 | Ruse Technologies, Llc | Multimode ICD system comprising phased array amplifiers to treat and manage CRT, CHF, and PVC disorders using ventricle level-shifting therapy to minimize VT/VF and SCA |
US11672982B2 (en) | 2018-11-13 | 2023-06-13 | Onward Medical N.V. | Control system for movement reconstruction and/or restoration for a patient |
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US11839766B2 (en) | 2019-11-27 | 2023-12-12 | Onward Medical N.V. | Neuromodulation system |
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US7346382B2 (en) | 2004-07-07 | 2008-03-18 | The Cleveland Clinic Foundation | Brain stimulation models, systems, devices, and methods |
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US11478644B2 (en) | 2020-04-22 | 2022-10-25 | Advanced Neuromodulation Systems, Inc. | Systems and methods for DC protection in implantable pulse generators |
Citations (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3699970A (en) * | 1969-06-26 | 1972-10-24 | Nat Res Dev | Striate cortex stimulator |
US4151470A (en) * | 1974-07-18 | 1979-04-24 | Olympus Optical Co., Ltd. | Combined portable tape recorder and stereophonic receiver system |
US4156259A (en) * | 1976-11-12 | 1979-05-22 | Olympus Optical Company | Tape recorder in which a cassette tape and a card are co-used |
US4180821A (en) * | 1975-10-14 | 1979-12-25 | Prewitt Richard H | Motion tape recorder |
US4612934A (en) * | 1981-06-30 | 1986-09-23 | Borkan William N | Non-invasive multiprogrammable tissue stimulator |
US4699143A (en) * | 1985-06-17 | 1987-10-13 | Minnesota Mining And Manufacturing Company | Electrical simulator for biological tissue having remote control |
US5354320A (en) * | 1991-09-12 | 1994-10-11 | Biotronik Mess- Und Therapiegerate Gmbh & Co., Ingenieurburo Berlin | Neurostimulator for production of periodic stimulation pulses |
US5503158A (en) * | 1994-08-22 | 1996-04-02 | Cardiocare, Inc. | Ambulatory electrocardiogram monitor |
US6044301A (en) * | 1998-04-29 | 2000-03-28 | Medtronic, Inc. | Audible sound confirmation of programming change in an implantable medical device |
US6208896B1 (en) * | 1998-11-13 | 2001-03-27 | Agilent Technologies, Inc. | Method and apparatus for providing variable defibrillation waveforms using switch-mode amplification |
US6249703B1 (en) * | 1994-07-08 | 2001-06-19 | Medtronic, Inc. | Handheld patient programmer for implantable human tissue stimulator |
US6289247B1 (en) * | 1998-06-02 | 2001-09-11 | Advanced Bionics Corporation | Strategy selector for multichannel cochlear prosthesis |
US6354299B1 (en) * | 1997-10-27 | 2002-03-12 | Neuropace, Inc. | Implantable device for patient communication |
US20020099421A1 (en) * | 2001-01-23 | 2002-07-25 | Manning Miles Goldsmith | Transcanal, transtympanic cochlear implant system for the rehabilitation of deafness and tinnitus |
US6516227B1 (en) * | 1999-07-27 | 2003-02-04 | Advanced Bionics Corporation | Rechargeable spinal cord stimulator system |
US20030093129A1 (en) * | 2001-10-29 | 2003-05-15 | Nicolelis Miguel A.L. | Closed loop brain machine interface |
US20030149457A1 (en) * | 2002-02-05 | 2003-08-07 | Neuropace, Inc. | Responsive electrical stimulation for movement disorders |
US6609031B1 (en) * | 1996-06-07 | 2003-08-19 | Advanced Neuromodulation Systems, Inc. | Multiprogrammable tissue stimulator and method |
US20030212440A1 (en) * | 2002-05-09 | 2003-11-13 | Boveja Birinder R. | Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system |
US6654642B2 (en) * | 1999-09-29 | 2003-11-25 | Medtronic, Inc. | Patient interactive neurostimulation system and method |
US6657106B2 (en) * | 1995-09-12 | 2003-12-02 | Isis Innovation Limited | Removal of metals from contaminated substrates by plants |
US6681136B2 (en) * | 2000-12-04 | 2004-01-20 | Science Medicus, Inc. | Device and method to modulate blood pressure by electrical waveforms |
US20040098067A1 (en) * | 2001-02-28 | 2004-05-20 | Jun Ohta | Built-in-eye- eyesight stimulating apparatus |
US6775573B2 (en) * | 2001-03-01 | 2004-08-10 | Science Medicus Inc. | Electrical method to control autonomic nerve stimulation of gastrointestinal tract |
US6778858B1 (en) * | 1999-09-16 | 2004-08-17 | Advanced Bionics N.V. | Cochlear implant |
US6934580B1 (en) * | 2002-07-20 | 2005-08-23 | Flint Hills Scientific, L.L.C. | Stimulation methodologies and apparatus for control of brain states |
US20050251061A1 (en) * | 2000-11-20 | 2005-11-10 | Schuler Eleanor L | Method and system to record, store and transmit waveform signals to regulate body organ function |
US20070000372A1 (en) * | 2005-04-13 | 2007-01-04 | The Cleveland Clinic Foundation | System and method for providing a waveform for stimulating biological tissue |
US7308302B1 (en) * | 2000-11-20 | 2007-12-11 | Schuler Eleanor L | Device and method to record, store and broadcast specific brain waveforms to modulate body organ functioning |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4424812A (en) * | 1980-10-09 | 1984-01-10 | Cordis Corporation | Implantable externally programmable microprocessor-controlled tissue stimulator |
US4598713A (en) * | 1982-06-29 | 1986-07-08 | Deutsche Nemectron Gmbh | Electrostimulation therapy device and method |
US4543955A (en) * | 1983-08-01 | 1985-10-01 | Cordis Corporation | System for controlling body implantable action device |
US4651740A (en) * | 1985-02-19 | 1987-03-24 | Cordis Corporation | Implant and control apparatus and method employing at least one tuning fork |
JPH02265571A (en) * | 1989-04-07 | 1990-10-30 | Omron Tateisi Electron Co | Low frequency remedial equipment |
WO1991010734A1 (en) * | 1990-01-12 | 1991-07-25 | Hsc Research Development Corporation | Introns and exons of the cystic fibrosis gene and mutations at various positions of the gene |
SE9300281D0 (en) * | 1993-01-29 | 1993-01-29 | Siemens Elema Ab | IMPLANTABLE MEDICAL DEVICE AND EXTRACORPORAL PROGRAMMING AND MONITORING DEVICE |
US5607460A (en) * | 1996-03-15 | 1997-03-04 | Angeion Corporation | Physician interface expert system for programming implantable arrythmia treatment devices |
US5891178A (en) | 1996-05-14 | 1999-04-06 | Pacesetter, Inc. | Programmer system and associated methods for rapidly evaluating and programming an implanted cardiac device |
US5938690A (en) * | 1996-06-07 | 1999-08-17 | Advanced Neuromodulation Systems, Inc. | Pain management system and method |
JP3255867B2 (en) | 1997-02-10 | 2002-02-12 | 株式会社伸貢製作所 | Potential therapy device |
US6662049B1 (en) * | 1997-12-17 | 2003-12-09 | Pacesetter, Inc. | Implantable device with a programmable reset mode and method of operation |
US6308099B1 (en) * | 1998-11-13 | 2001-10-23 | Intermedics Inc. | Implantable device and programmer system which permits multiple programmers |
US6539263B1 (en) * | 1999-06-11 | 2003-03-25 | Cornell Research Foundation, Inc. | Feedback mechanism for deep brain stimulation |
US6804558B2 (en) * | 1999-07-07 | 2004-10-12 | Medtronic, Inc. | System and method of communicating between an implantable medical device and a remote computer system or health care provider |
US6263246B1 (en) * | 1999-09-14 | 2001-07-17 | Medtronic, Inc. | Method and apparatus for communications with an implantable device |
FI19992484A (en) * | 1999-11-22 | 2001-05-23 | Polar Electro Oy | A method for performing the operation settings of a heart rate measurement arrangement and a heart rate measurement arrangement |
US6418346B1 (en) * | 1999-12-14 | 2002-07-09 | Medtronic, Inc. | Apparatus and method for remote therapy and diagnosis in medical devices via interface systems |
US6587724B2 (en) * | 1999-12-17 | 2003-07-01 | Advanced Bionics Corporation | Magnitude programming for implantable electrical stimulator |
US6505079B1 (en) * | 2000-09-13 | 2003-01-07 | Foster Bio Technology Corp. | Electrical stimulation of tissue for therapeutic and diagnostic purposes |
US6560490B2 (en) * | 2000-09-26 | 2003-05-06 | Case Western Reserve University | Waveforms for selective stimulation of central nervous system neurons |
US6628989B1 (en) * | 2000-10-16 | 2003-09-30 | Remon Medical Technologies, Ltd. | Acoustic switch and apparatus and methods for using acoustic switches within a body |
US6622045B2 (en) * | 2001-03-29 | 2003-09-16 | Pacesetter, Inc. | System and method for remote programming of implantable cardiac stimulation devices |
US20030208244A1 (en) * | 2002-04-26 | 2003-11-06 | Medtronic, Inc. | Voltage/current regulator improvements for an implantable medical device |
US7483748B2 (en) * | 2002-04-26 | 2009-01-27 | Medtronic, Inc. | Programmable waveform pulses for an implantable medical device |
US7024246B2 (en) * | 2002-04-26 | 2006-04-04 | Medtronic, Inc | Automatic waveform output adjustment for an implantable medical device |
US6950706B2 (en) * | 2002-04-26 | 2005-09-27 | Medtronic, Inc. | Wave shaping for an implantable medical device |
US7715912B2 (en) * | 2005-04-13 | 2010-05-11 | Intelect Medical, Inc. | System and method for providing a waveform for stimulating biological tissue |
-
2006
- 2006-04-13 US US11/404,476 patent/US20060239482A1/en not_active Abandoned
- 2006-04-13 WO PCT/US2006/013776 patent/WO2006113305A2/en active Application Filing
- 2006-04-13 US US11/404,006 patent/US8082033B2/en active Active
- 2006-04-13 WO PCT/US2006/013989 patent/WO2006113397A2/en active Application Filing
- 2006-04-13 EP EP06740916A patent/EP1871465A2/en not_active Withdrawn
Patent Citations (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3699970A (en) * | 1969-06-26 | 1972-10-24 | Nat Res Dev | Striate cortex stimulator |
US4151470A (en) * | 1974-07-18 | 1979-04-24 | Olympus Optical Co., Ltd. | Combined portable tape recorder and stereophonic receiver system |
US4180821A (en) * | 1975-10-14 | 1979-12-25 | Prewitt Richard H | Motion tape recorder |
US4156259A (en) * | 1976-11-12 | 1979-05-22 | Olympus Optical Company | Tape recorder in which a cassette tape and a card are co-used |
US4612934A (en) * | 1981-06-30 | 1986-09-23 | Borkan William N | Non-invasive multiprogrammable tissue stimulator |
US4699143A (en) * | 1985-06-17 | 1987-10-13 | Minnesota Mining And Manufacturing Company | Electrical simulator for biological tissue having remote control |
US5354320A (en) * | 1991-09-12 | 1994-10-11 | Biotronik Mess- Und Therapiegerate Gmbh & Co., Ingenieurburo Berlin | Neurostimulator for production of periodic stimulation pulses |
US6249703B1 (en) * | 1994-07-08 | 2001-06-19 | Medtronic, Inc. | Handheld patient programmer for implantable human tissue stimulator |
US5503158A (en) * | 1994-08-22 | 1996-04-02 | Cardiocare, Inc. | Ambulatory electrocardiogram monitor |
US6657106B2 (en) * | 1995-09-12 | 2003-12-02 | Isis Innovation Limited | Removal of metals from contaminated substrates by plants |
US6609031B1 (en) * | 1996-06-07 | 2003-08-19 | Advanced Neuromodulation Systems, Inc. | Multiprogrammable tissue stimulator and method |
US6354299B1 (en) * | 1997-10-27 | 2002-03-12 | Neuropace, Inc. | Implantable device for patient communication |
US6044301A (en) * | 1998-04-29 | 2000-03-28 | Medtronic, Inc. | Audible sound confirmation of programming change in an implantable medical device |
US6289247B1 (en) * | 1998-06-02 | 2001-09-11 | Advanced Bionics Corporation | Strategy selector for multichannel cochlear prosthesis |
US6208896B1 (en) * | 1998-11-13 | 2001-03-27 | Agilent Technologies, Inc. | Method and apparatus for providing variable defibrillation waveforms using switch-mode amplification |
US6516227B1 (en) * | 1999-07-27 | 2003-02-04 | Advanced Bionics Corporation | Rechargeable spinal cord stimulator system |
US6778858B1 (en) * | 1999-09-16 | 2004-08-17 | Advanced Bionics N.V. | Cochlear implant |
US6654642B2 (en) * | 1999-09-29 | 2003-11-25 | Medtronic, Inc. | Patient interactive neurostimulation system and method |
US7308302B1 (en) * | 2000-11-20 | 2007-12-11 | Schuler Eleanor L | Device and method to record, store and broadcast specific brain waveforms to modulate body organ functioning |
US20050251061A1 (en) * | 2000-11-20 | 2005-11-10 | Schuler Eleanor L | Method and system to record, store and transmit waveform signals to regulate body organ function |
US6681136B2 (en) * | 2000-12-04 | 2004-01-20 | Science Medicus, Inc. | Device and method to modulate blood pressure by electrical waveforms |
US20020099421A1 (en) * | 2001-01-23 | 2002-07-25 | Manning Miles Goldsmith | Transcanal, transtympanic cochlear implant system for the rehabilitation of deafness and tinnitus |
US20040098067A1 (en) * | 2001-02-28 | 2004-05-20 | Jun Ohta | Built-in-eye- eyesight stimulating apparatus |
US6775573B2 (en) * | 2001-03-01 | 2004-08-10 | Science Medicus Inc. | Electrical method to control autonomic nerve stimulation of gastrointestinal tract |
US20030093129A1 (en) * | 2001-10-29 | 2003-05-15 | Nicolelis Miguel A.L. | Closed loop brain machine interface |
US20030149457A1 (en) * | 2002-02-05 | 2003-08-07 | Neuropace, Inc. | Responsive electrical stimulation for movement disorders |
US20030212440A1 (en) * | 2002-05-09 | 2003-11-13 | Boveja Birinder R. | Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system |
US6934580B1 (en) * | 2002-07-20 | 2005-08-23 | Flint Hills Scientific, L.L.C. | Stimulation methodologies and apparatus for control of brain states |
US20070000372A1 (en) * | 2005-04-13 | 2007-01-04 | The Cleveland Clinic Foundation | System and method for providing a waveform for stimulating biological tissue |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8082033B2 (en) * | 2005-04-13 | 2011-12-20 | The Cleveland Clinic Foundation | System and method for providing a waveform for stimulating biological tissue |
US20070000372A1 (en) * | 2005-04-13 | 2007-01-04 | The Cleveland Clinic Foundation | System and method for providing a waveform for stimulating biological tissue |
US9211408B2 (en) | 2005-04-13 | 2015-12-15 | The Cleveland Clinic Foundation | System and method for neuromodulation using composite patterns of stimulation or waveforms |
US9339650B2 (en) | 2005-04-13 | 2016-05-17 | The Cleveland Clinic Foundation | Systems and methods for neuromodulation using pre-recorded waveforms |
CN102421477A (en) * | 2009-04-24 | 2012-04-18 | 康尔福盛2200公司 | Cortical stimulator method and apparatus |
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US10328262B2 (en) | 2010-11-16 | 2019-06-25 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
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US9409011B2 (en) | 2011-01-21 | 2016-08-09 | California Institute Of Technology | Method of constructing an implantable microelectrode array |
US9931508B2 (en) | 2011-03-24 | 2018-04-03 | California Institute Of Technology | Neurostimulator devices using a machine learning method implementing a gaussian process optimization |
US10737095B2 (en) | 2011-03-24 | 2020-08-11 | Californina Institute of Technology | Neurostimulator |
US9409023B2 (en) | 2011-03-24 | 2016-08-09 | California Institute Of Technology | Spinal stimulator systems for restoration of function |
US10092750B2 (en) | 2011-11-11 | 2018-10-09 | Neuroenabling Technologies, Inc. | Transcutaneous neuromodulation system and methods of using same |
US11638820B2 (en) | 2011-11-11 | 2023-05-02 | The Regents Of The University Of California | Transcutaneous neuromodulation system and methods of using same |
US9415218B2 (en) | 2011-11-11 | 2016-08-16 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
US10806927B2 (en) | 2011-11-11 | 2020-10-20 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
US11033736B2 (en) | 2011-11-11 | 2021-06-15 | The Regents Of The University Of California | Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function |
US10881853B2 (en) | 2011-11-11 | 2021-01-05 | The Regents Of The University Of California, A California Corporation | Transcutaneous neuromodulation system and methods of using same |
US10124166B2 (en) | 2011-11-11 | 2018-11-13 | Neuroenabling Technologies, Inc. | Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function |
US9393409B2 (en) | 2011-11-11 | 2016-07-19 | Neuroenabling Technologies, Inc. | Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function |
US9717627B2 (en) | 2013-03-12 | 2017-08-01 | Oculeve, Inc. | Implant delivery devices, systems, and methods |
US10537469B2 (en) | 2013-03-12 | 2020-01-21 | Oculeve, Inc. | Implant delivery devices, systems, and methods |
US11400284B2 (en) | 2013-03-15 | 2022-08-02 | The Regents Of The University Of California | Method of transcutaneous electrical spinal cord stimulation for facilitation of locomotion |
US9993642B2 (en) | 2013-03-15 | 2018-06-12 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
US10967173B2 (en) | 2013-04-19 | 2021-04-06 | Oculeve, Inc. | Nasal stimulation devices and methods for treating dry eye |
US9737702B2 (en) | 2013-04-19 | 2017-08-22 | Oculeve, Inc. | Nasal stimulation devices and methods |
US10238861B2 (en) | 2013-04-19 | 2019-03-26 | Oculeve, Inc. | Nasal stimulation devices and methods for treating dry eye |
US10155108B2 (en) | 2013-04-19 | 2018-12-18 | Oculeve, Inc. | Nasal stimulation devices and methods |
US10835738B2 (en) | 2013-04-19 | 2020-11-17 | Oculeve, Inc. | Nasal stimulation devices and methods |
US10799695B2 (en) | 2013-04-19 | 2020-10-13 | Oculeve, Inc. | Nasal stimulation devices and methods |
US11123312B2 (en) | 2013-09-27 | 2021-09-21 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
US10137299B2 (en) | 2013-09-27 | 2018-11-27 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
US10786673B2 (en) | 2014-01-13 | 2020-09-29 | California Institute Of Technology | Neuromodulation systems and methods of using same |
US9770583B2 (en) | 2014-02-25 | 2017-09-26 | Oculeve, Inc. | Polymer formulations for nasolacrimal stimulation |
US9956397B2 (en) | 2014-02-25 | 2018-05-01 | Oculeve, Inc. | Polymer Formulations for nasolacrimal stimulation |
US10799696B2 (en) | 2014-02-25 | 2020-10-13 | Oculeve, Inc. | Polymer formulations for nasolacrimal stimulation |
US10722713B2 (en) | 2014-07-25 | 2020-07-28 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
US9687652B2 (en) * | 2014-07-25 | 2017-06-27 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
US20160022992A1 (en) * | 2014-07-25 | 2016-01-28 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
JP2020096842A (en) * | 2014-07-25 | 2020-06-25 | オキュリーブ, インコーポレイテッド | Stimulation patterns for treating dry eye |
JP2017522127A (en) * | 2014-07-25 | 2017-08-10 | オキュリーブ, インコーポレイテッド | Stimulation patterns for treating dry eye |
AU2015292278B2 (en) * | 2014-07-25 | 2020-04-09 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
US10751533B2 (en) | 2014-08-21 | 2020-08-25 | The Regents Of The University Of California | Regulation of autonomic control of bladder voiding after a complete spinal cord injury |
US10773074B2 (en) | 2014-08-27 | 2020-09-15 | The Regents Of The University Of California | Multi-electrode array for spinal cord epidural stimulation |
US10780273B2 (en) | 2014-10-22 | 2020-09-22 | Oculeve, Inc. | Stimulation devices and methods for treating dry eye |
US9737712B2 (en) | 2014-10-22 | 2017-08-22 | Oculeve, Inc. | Stimulation devices and methods for treating dry eye |
US10610695B2 (en) | 2014-10-22 | 2020-04-07 | Oculeve, Inc. | Implantable device for increasing tear production |
US10207108B2 (en) | 2014-10-22 | 2019-02-19 | Oculeve, Inc. | Implantable nasal stimulator systems and methods |
US10112048B2 (en) | 2014-10-22 | 2018-10-30 | Oculeve, Inc. | Stimulation devices and methods for treating dry eye |
US9764150B2 (en) | 2014-10-22 | 2017-09-19 | Oculeve, Inc. | Contact lens for increasing tear production |
US11298533B2 (en) | 2015-08-26 | 2022-04-12 | The Regents Of The University Of California | Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject |
CN108024753A (en) * | 2015-10-27 | 2018-05-11 | 赫尔实验室有限公司 | In order to which technical ability obtains and consolidates being controlled through cranium for progress again to nondeclarative memory |
US20170312519A1 (en) * | 2015-10-27 | 2017-11-02 | Hrl Laboratories, Llc | Transcranial control of procedural memory reconsolidation for skill acquisition |
US10238870B2 (en) * | 2015-10-27 | 2019-03-26 | Hrl Laboratories, Llc | Transcranial control of procedural memory reconsolidation for skill acquisition |
US11097122B2 (en) | 2015-11-04 | 2021-08-24 | The Regents Of The University Of California | Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel |
US10426958B2 (en) | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
US10940310B2 (en) | 2016-02-19 | 2021-03-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
US10918864B2 (en) | 2016-05-02 | 2021-02-16 | Oculeve, Inc. | Intranasal stimulation for treatment of meibomian gland disease and blepharitis |
US10646164B1 (en) * | 2016-05-24 | 2020-05-12 | Stimwave Technologies Incorporated | Pulse-density modulation to synthesize stimulation waveforms on an implantable device |
US11672488B1 (en) * | 2016-05-24 | 2023-06-13 | Stimwave Technologies Incorporated | Pulse-density modulation to synthesize stimulation waveforms on an implantable device |
US10610095B2 (en) | 2016-12-02 | 2020-04-07 | Oculeve, Inc. | Apparatus and method for dry eye forecast and treatment recommendation |
US11691015B2 (en) | 2017-06-30 | 2023-07-04 | Onward Medical N.V. | System for neuromodulation |
US11723579B2 (en) | 2017-09-19 | 2023-08-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
US11318277B2 (en) | 2017-12-31 | 2022-05-03 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
US11478603B2 (en) | 2017-12-31 | 2022-10-25 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
US11273283B2 (en) | 2017-12-31 | 2022-03-15 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
US11452839B2 (en) | 2018-09-14 | 2022-09-27 | Neuroenhancement Lab, LLC | System and method of improving sleep |
CN109157209A (en) * | 2018-10-25 | 2019-01-08 | 江南大学 | A kind of compressed sensing based processing of bioelectric signals circuit and method |
US11672982B2 (en) | 2018-11-13 | 2023-06-13 | Onward Medical N.V. | Control system for movement reconstruction and/or restoration for a patient |
US11672983B2 (en) | 2018-11-13 | 2023-06-13 | Onward Medical N.V. | Sensor in clothing of limbs or footwear |
US11752342B2 (en) | 2019-02-12 | 2023-09-12 | Onward Medical N.V. | System for neuromodulation |
US11839766B2 (en) | 2019-11-27 | 2023-12-12 | Onward Medical N.V. | Neuromodulation system |
US11484718B2 (en) | 2021-01-22 | 2022-11-01 | Ruse Technologies, Llc | Multimode ICD system comprising phased array amplifiers to treat and manage CRT, CHF, and PVC disorders using ventricle level-shifting therapy to minimize VT/VF and SCA |
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WO2006113305A2 (en) | 2006-10-26 |
US8082033B2 (en) | 2011-12-20 |
WO2006113397A3 (en) | 2007-01-18 |
EP1871465A2 (en) | 2008-01-02 |
WO2006113397A2 (en) | 2006-10-26 |
WO2006113305A3 (en) | 2006-12-28 |
US20070000372A1 (en) | 2007-01-04 |
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