US20080058683A1 - Method and apparatus for non-invasively treating patent foramen ovale using high intensity focused ultrasound - Google Patents
Method and apparatus for non-invasively treating patent foramen ovale using high intensity focused ultrasound Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
- A61B8/4488—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer the transducer being a phased array
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
- A61B2090/3782—Surgical systems with images on a monitor during operation using ultrasound transmitter or receiver in catheter or minimal invasive instrument
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0883—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of the heart
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
Definitions
- the present invention relates to methods and apparatus for treatment of patent foramen ovale, and more particularly, to the use of high intensity focused ultrasound non-invasively to treat patent foramen ovale.
- Patent foramen ovale is characterized by a persistent fetal opening between the left and right atria of the heart that allows blood to bypass the lungs. In most people, this opening permanently closes during the first few months after birth. However, a PFO is present in up to 15 percent of adults.
- PFO may be associated with various heart conditions including paradoxical embolus, in which an embolus arising in venous circulation gains access to the arterial circulation through the PFO, thereby resulting in stroke or transient ischemic attack.
- Closure of PFO using a transcatheter approach may be medically necessary for patients with a history of cryptogenic stroke that are not candidates for anticoagulant therapy.
- Implantable devices such as those of AGA Medical Corporation (Golden Valley, Minn.) and NMT Medical, Inc. (Boston, Mass.) are used to close PFOs.
- the following devices pertain to the use of high intensity focused ultrasound (HIFU) energy to weld the tissues of a PFO closed.
- HIFU high intensity focused ultrasound
- Each device is used for application of energy to the tissues to be sealed.
- Heating of the tissues of the PFO by the HIFU causes a healing response which causes the formerly separate tissues of the PFO to heal together.
- the energy denatures the collagen of the tissues of the different portions of the PFO, and the tissues are caused to remain in close apposition in order to allow the collagen to bond while the tissue return to normal body temperature.
- WO 99/18871 and WO 99/18870 to Laufer, et al. (now abandoned) describe the heating of the tissue of a PFO to induce closure through natural wound healing. These, however are invasive devices which require entering and crossing the PFO. Additionally, U.S. Pat. No. 6,562,037 to Paton et al. describes in detail methods and considerations for the rejoining of two tissue sections through the precise application of energy in a two-stage algorithm, wherein all voltage levels used are empirically derived and pre-programmed into the energy delivery control system. Again, however, all devices described would need to be in contact with the tissues to be joined.
- Radio-frequency electrical energy, microwaves, cryothermia probes, alcohol injection, laser light, and ultrasound energy are just a few of the technologies that have been pursued.
- kidney stones generally are located within the body at a significant depth from the skin.
- One ultrasound imaging system is used to aim the system at the kidney stones, and then a second, high energy ultrasound system delivers energy that breaks up the stones so they can be passed.
- Therus Corp. of Seattle, Wash. has developed a system to seal blood vessels after the vessels have been punctured to insert sheaths and catheters.
- Therus system shrinks and seals femoral artery punctures at a depth of approximately 5 cm.
- Timi-3 Systems, Inc. Santa Clara, Calif.
- Timi-3 Systems, Inc. Santa Clara, Calif.
- This system delivers energy at a frequency intended to accelerate thrombolysis without damaging the myocardium or vasculature of the heart.
- the Epicor Medical, Inc. of Sunnyvale, Calif. has developed a localized high intensity focused ultrasound (“HIFU”) device to create lesions in the atrial walls.
- the Epicor device is a hand-held intraoperative surgical device, and is configured to be held directly against the epicardium or outside wall of the heart. When energized, the device creates full-thickness lesions through the atrial wall of the heart, and has demonstrated that ultrasound energy may be safely and effectively used to create atrial lesions, despite presence of blood flow past the interior wall of the atrium.
- Transurgical, Inc. Setauket, N.Y. has been actively developing HIFU devices.
- Epicor Medical devices are placed in close approximation against the outside of the heart, the Transurgical devices are directed to intravascular catheters for heating or ablating tissue in the heart and require that the catheter be brought into close approximation with the targeted tissue.
- FIG. 1 is a schematic view of an illustrative imaging and treatment ultrasound system of the present invention
- FIG. 2 is a schematic view of an illustrative display of the imaging and treatment ultrasound system of the present invention
- FIG. 3 is a schematic view showing the imaging and treatment ultrasound system of FIG. 1 disposed adjacent to a cross-section of a patient's thorax;
- FIG. 4 is a schematic view of the distal region of a catheter-based high intensity focused ultrasound array.
- the present invention is directed to methods and apparatus for creating lesions in the walls of the heart or for ablating or welding the tissue of a PFO in a non-invasive manner using high intensity focused ultrasound (HIFU).
- HIFU high intensity focused ultrasound
- Previously-known HIFU systems such as those being developed by Epicor Medical or Transurgical, require close approximation of the HIFU device to the target tissue. These systems are not adapted for PFO closure.
- the methods and apparatus of the present invention overcome this drawback by providing systems that enable the creation of lesions in the heart wall from a greater distance.
- System 10 comprises head 11 housing ultrasound imaging system 12 and high intensity focused ultrasound energy (“HIFU”) system 14 .
- Ultrasound imaging system 12 and HIFU system 14 may have in common all or just a subset of the transducers and related components, operating in different modes to image or ablate.
- Head 11 is mounted on arm 13 that permits the head to be positioned in contact with a patient (not shown) lying on table 15 .
- Head 11 also may be a handheld unit, not needing an arm 13 to support or position it.
- System 10 includes controller 16 that controls operation of imaging system 12 and HIFU system 14 .
- Monitor 18 displays images output by imaging system 12 that allows the clinician to identify the desired locations on the walls of the heart to be treated.
- controller 16 and monitor 18 also are programmed to indicate the focus of the HIFU energy relative to the image of the tissue cross-section.
- FIG. 2 shows illustrative screen display 19 of monitor 18 wherein the outline T of the tissue, as imaged by imaging system 12 ., and a marker corresponding to the location of focal point F of HIFU system 14 , may be seen.
- the HIFU system When activated, the HIFU system delivers ablative energy to the specific location shown on monitor 18 (focal point F in FIG. 2 ), thus enabling safe creation of lesions or tissue welds. Because the HIFU system is configured to deliver energy from a number of sources focused towards the target tissue area, intervening tissue is subjected to only a fraction of the energy deposited in the target tissue receives, and thus the intervening tissue is not significantly heated or ablated.
- ultrasound imaging system 12 may be similar in design to previously-known trans-thoracic ultrasound imaging systems, and are per se known.
- High intensity focused ultrasound system 14 may comprise one or more HIFU generators 20 constructed as described in U.S. Patent Publication No. US20010031922A1.
- imaging system 12 and HIFU system 14 also may use common elements.
- each HIFU generator 20 is the same as or is disposed approximately in the same plane as the imaging elements of ultrasound imaging system 12 , so that the focus of HIFU system 14 occurs in the plane of the target tissue imaged by ultrasound imaging system 12 .
- this arrangement advantageously ensures that the HIFU energy will reach the target.
- HIFU generators 20 deliver energy at a frequency optimized for heating myocardium, so that the lesions created will weld, occlude, or lead to the occlusion of the patent foramen ovale. Once the lesions are created, a gradual healing process is begun in which the lesions fibrose, thus permanently sealing the opening.
- controller 16 may be programmed to time-gate operation of imaging system 12 and HIFU system 14 , so that the tissue is alternately imaged and ablated at a frequency of up to several times per second.
- controller 16 may include suitable programming and joystick 22 , or other input device, for refocusing the focal point of HIFU system 14 along a desired trajectory.
- the HIFU system is used to create localized tissue heating of the septum primum and septum secundum that will lead to occlusion of a PFO.
- the consequent healing process is expected to cause the septum primum and septum secundum to heal together, thereby permanently closing the PFO or resulting in acute welding of the tissues.
- this non-invasive treatment were to be effective in closing PFO in only a small percentage of cases, the procedure would likely become the first choice for use in initial therapy.
- the tissues of the septum primum and the septum secundum preferably are in contact when the energy is applied to facilitate welding of the PFO.
- Adequate apposition exists in many patients in the absence of an elevated right atrial pressure. However, in some cases it may be necessary or desirable to artificially increase the pressure gradient between the right and left atria to ensure closure of the PFO and/or to increase the contact pressure between the septum primum and septum secundum.
- Closure of the PFO or increased contact pressure between the septum primum and septum secundum can be achieved noninvasively through a variety of known techniques using medications, mechanical expedients, or a combination of the two.
- briefly applying external pressure to a patient's jugular veins will temporarily limit blood flow into the superior vena cava and hence the right atrium. Of course, this lowers the right atrial pressure relative to the left atrial pressure, thereby creating the desired closure or increase in contact pressure.
- the desired closure or increase in contact pressure may be achieved by administering drugs that increase the patient's blood pressure by increasing heart rate and/or peripheral resistance.
- One suitable drug for increasing heart rate is epinephrine.
- such drugs may be administered in combination with the application of pressure to the patient's jugular veins.
- the focus of the HIFU system is fixed at a certain point within the field of the ultrasound image.
- the ultrasound image might show a picture of rectangular planar cross-section of tissue with a fixed focus of the HIFU energy in the center of the field.
- the clinician manually moves the probe until the desired tissue is in the target area, and then fires the HIFU system to ablate the tissue and occlude or weld the PFO.
- the HIFU system includes fluid-filled balloon 24 that covers the face of the probe.
- Balloon 24 preferably is filled with water and enables the clinician to reposition the probe at a variable distance from the skin. Balloon 24 also permits the clinician to position the probe at any desired angle to target tissue not aligned directly under the focal point of HIFU system 14 . Alternatively, the patient could sit in a tub of water, so the patient's chest and the probe were both underwater, again ensuring a continuous fluid path.
- controller 16 may be programmed so that the depth of the focal point of the HIFU system is depth-adjustable relative to the imaged tissue.
- the depth of the targeted tissue then could be adjusted relative to the imaged field, so a smaller fluid-filled balloon, or no balloon, is used to maintain fluid contact while adjusting the angle of the imaged section or make minor changes in the depth of the targeted tissue.
- WIPO Patent Publication No. WO/0145550A2 to Therus describes several ways to adjust the depth of the focused energy by changing the radius of curvature of one or more of the ultrasound generators. Alternatively, the direction of several focused energy generators of relatively fixed focal length could be shifted relative to one another to move the focal point.
- focused energy is applied from outside the patient's body. Because ultrasound energy does not travel coherently through non-fluid filled tissue, such as the lungs, positioning of the ultrasound imaging system and HIFU system at certain angles may be more advantageous for treatment of specific areas of the heart.
- the imaging system and HIFU system may be located on a movable arm or to position it by hand so as to permit other external approaches, such as from below the diaphragm on the left anterior side of the body, so the ultrasound has a coherent path through the diaphragm and apex and ventricles of the heart to the septa.
- Application of the probe also may be made along a patient's back.
- Intraluminal probe 30 is configured to deliver HIFU energy to the heart from the esophagus, from the aorta, or from the great veins of the heart such as the inferior vena cava, superior vena cava, or the right atrium itself.
- catheter 30 preferably has a diameter in a range of 5 to 10 mm for vascular devices, and a diameter in a range of 5 to 20 mm for an esophageal device.
- Imaging elements 32 and HIFU elements 34 are arranged linearly along the longitudinal axis of the catheter.
- the linear nature of the imaging element and HIFU element array may impose limitations on the ability to reposition the device. While translation and rotation of the catheter may be relatively easy, it is contemplated that it may be difficult to move the device very far to one side or another within a relatively small-diameter body lumen.
- intraluminal catheter 30 preferably is configured to adjust the focal point of the HIFU system with respect to both longitudinal position and depth. This may be accomplished by programming the controller used with intraluminal catheter 30 to adjust the focal point of the HIFU system, as described above. Alternatively, refocusing of the array of HIFU elements may be achieved by locating individual HIFU elements on independently steerable actuators 36 . Actuators 36 are controlled by the system controller and permit the clinician to move the focal point of the HIFU array to any desired point in the field of view of the imaging system.
- intraluminal catheter 30 preferably is configured, either mechanically or by suitable software algorithms, to move its focal point to enable a continuous linear ablation or heat affected zone without moving the device.
- the HIFU array of the catheter may be configured to create a linear ablation or heat affected zone, or have a fixed-focus so that a linear ablation or heat affected zone may be created by translating the HIFU array within the esophagus.
- Intraluminal catheter 30 may therefore include a water jacket that circulates fluid around the HIFU array to prevent any heat generated by the array or ultrasound energy absorbed by the esophagus from causing any tissue damage.
Abstract
Methods and apparatus are provided for non-invasively treating patent foramen ovale using an ultrasound imaging system and a high intensity focused ultrasound system to selectively target high intensity ultrasound energy on either or both of a patient's septum primum or septum secundum.
Description
- This application is a divisional of U.S. application Ser. No. 10/764,148 (Attorney Docket No. 022128-000510US), filed Jan. 23, 2004, which claims priority from provisional U.S. Application No. 60/477,532 (Attorney Docket No. 022128-000500US), filed Jun. 10, 2003. The full disclosures of each of these applications are incorporated herein by reference.
- 1. Field of the Invention
- The present invention relates to methods and apparatus for treatment of patent foramen ovale, and more particularly, to the use of high intensity focused ultrasound non-invasively to treat patent foramen ovale.
- 2. Background of the Invention
- Up until the 1980s, there was dramatic growth in the creation of new surgical methods for treating a wide variety of previously untreated conditions. Over the past twenty years there has been a clear trend towards the invention of devices and methods that enable less-invasive treatment of such diseases, moving from invasive surgery, and then to less-invasive surgery, and to interventional techniques. Ultimately, it is desirable to move to totally non-invasive therapies.
- Patent foramen ovale (PFO) is characterized by a persistent fetal opening between the left and right atria of the heart that allows blood to bypass the lungs. In most people, this opening permanently closes during the first few months after birth. However, a PFO is present in up to 15 percent of adults.
- PFO may be associated with various heart conditions including paradoxical embolus, in which an embolus arising in venous circulation gains access to the arterial circulation through the PFO, thereby resulting in stroke or transient ischemic attack. Closure of PFO using a transcatheter approach may be medically necessary for patients with a history of cryptogenic stroke that are not candidates for anticoagulant therapy. Implantable devices, such as those of AGA Medical Corporation (Golden Valley, Minn.) and NMT Medical, Inc. (Boston, Mass.) are used to close PFOs.
- It would be desirable to develop methods of treating PFO that are even less invasive than transvascular interventional techniques, thereby eliminating the need for catheters.
- The following devices pertain to the use of high intensity focused ultrasound (HIFU) energy to weld the tissues of a PFO closed. Each device is used for application of energy to the tissues to be sealed. Heating of the tissues of the PFO by the HIFU causes a healing response which causes the formerly separate tissues of the PFO to heal together. In some embodiments, the energy denatures the collagen of the tissues of the different portions of the PFO, and the tissues are caused to remain in close apposition in order to allow the collagen to bond while the tissue return to normal body temperature.
- By way of example, WO 99/18871 and WO 99/18870 to Laufer, et al. (now abandoned) describe the heating of the tissue of a PFO to induce closure through natural wound healing. These, however are invasive devices which require entering and crossing the PFO. Additionally, U.S. Pat. No. 6,562,037 to Paton et al. describes in detail methods and considerations for the rejoining of two tissue sections through the precise application of energy in a two-stage algorithm, wherein all voltage levels used are empirically derived and pre-programmed into the energy delivery control system. Again, however, all devices described would need to be in contact with the tissues to be joined. Relevant articles from the clinical literature include “High-burst-strength, feedback-controlled bipolar vessel sealing,” Kennedy et al., Surg Endosc (1998) 12:876-878. This article describes the development of a system for use in open or laparoscopic surgical procedures for achieving hemostasis in large-diameter arteries through the use of RF welding.
- A wide variety of energy modes have been used to create lesions using epicardial or intracardiac probes. Radio-frequency electrical energy, microwaves, cryothermia probes, alcohol injection, laser light, and ultrasound energy are just a few of the technologies that have been pursued.
- Separately, several groups have developed focused ultrasound devices with both imaging and therapeutic capabilities. These efforts began perhaps with lithotripsy, in which a high power focused ultrasound system developed by Dornier Medizintechnik, Germany, was used to break up kidney stones in the body. The kidney stones generally are located within the body at a significant depth from the skin. One ultrasound imaging system is used to aim the system at the kidney stones, and then a second, high energy ultrasound system delivers energy that breaks up the stones so they can be passed.
- More recently, Therus Corp. of Seattle, Wash., has developed a system to seal blood vessels after the vessels have been punctured to insert sheaths and catheters. The Therus system shrinks and seals femoral artery punctures at a depth of approximately 5 cm.
- In addition, Timi-3 Systems, Inc., Santa Clara, Calif., has developed and is testing a trans-thoracic ultrasound energy delivery system to accelerate the thrombolysis process for patients suffering an acute myocardial infarction. This system delivers energy at a frequency intended to accelerate thrombolysis without damaging the myocardium or vasculature of the heart.
- Epicor Medical, Inc. of Sunnyvale, Calif., has developed a localized high intensity focused ultrasound (“HIFU”) device to create lesions in the atrial walls. The Epicor device is a hand-held intraoperative surgical device, and is configured to be held directly against the epicardium or outside wall of the heart. When energized, the device creates full-thickness lesions through the atrial wall of the heart, and has demonstrated that ultrasound energy may be safely and effectively used to create atrial lesions, despite presence of blood flow past the interior wall of the atrium.
- In addition, Transurgical, Inc., Setauket, N.Y. has been actively developing HIFU devices. However, while the Epicor Medical devices are placed in close approximation against the outside of the heart, the Transurgical devices are directed to intravascular catheters for heating or ablating tissue in the heart and require that the catheter be brought into close approximation with the targeted tissue.
- In view of the aforementioned limitations or previously-known devices and methods, it would be desirable to provide methods and apparatus for treating PFO by heating or ablating tissue at a distance from that tissue, so that the procedure may be performed non-invasively.
- It also would be desirable to provide methods and apparatus for treating PFO by applying energy from outside the body or from organs, such as the esophagus, that are easily accessible via natural body openings.
- In view of the foregoing, it is an object of the present invention to provide methods and apparatus for treating PFO so as to cause closure by ablating or applying energy to weld the tissue at a distance from that tissue, so that the procedure may be performed non-invasively.
- It is another object of the present invention to provide methods and apparatus for treating PFO by applying energy from outside the body or from neighboring organs, such as the esophagus, that are easily accessible.
- These and other objects of the present invention are accomplished by providing methods and apparatus that enable a physician to image tissue within the body that is to be heated or ablated, and then to heat or ablate that tissue using a completely or relatively non-invasive procedure, and with little or no anesthesia. Advantageously, the methods and apparatus of the present invention are expected to be cost-effective and time-efficient to perform compared to the previously-known surgical and interventional procedures.
- The above and other objects and advantages of the present invention will be apparent upon consideration of the following detailed description, taken in conjunction with the accompanying drawings, in which like reference characters refer to like parts throughout, and in which:
-
FIG. 1 is a schematic view of an illustrative imaging and treatment ultrasound system of the present invention; -
FIG. 2 is a schematic view of an illustrative display of the imaging and treatment ultrasound system of the present invention; -
FIG. 3 is a schematic view showing the imaging and treatment ultrasound system ofFIG. 1 disposed adjacent to a cross-section of a patient's thorax; and -
FIG. 4 is a schematic view of the distal region of a catheter-based high intensity focused ultrasound array. - The present invention is directed to methods and apparatus for creating lesions in the walls of the heart or for ablating or welding the tissue of a PFO in a non-invasive manner using high intensity focused ultrasound (HIFU). Previously-known HIFU systems, such as those being developed by Epicor Medical or Transurgical, require close approximation of the HIFU device to the target tissue. These systems are not adapted for PFO closure. The methods and apparatus of the present invention overcome this drawback by providing systems that enable the creation of lesions in the heart wall from a greater distance.
- Referring to
FIG. 1 , apparatus constructed in accordance with the principles of the present invention is described.System 10 compriseshead 11 housingultrasound imaging system 12 and high intensity focused ultrasound energy (“HIFU”)system 14.Ultrasound imaging system 12 andHIFU system 14 may have in common all or just a subset of the transducers and related components, operating in different modes to image or ablate.Head 11 is mounted onarm 13 that permits the head to be positioned in contact with a patient (not shown) lying on table 15.Head 11 also may be a handheld unit, not needing anarm 13 to support or position it.System 10 includescontroller 16 that controls operation ofimaging system 12 andHIFU system 14.Monitor 18 displays images output by imagingsystem 12 that allows the clinician to identify the desired locations on the walls of the heart to be treated. - In accordance with the methods of the present invention,
controller 16 and monitor 18 also are programmed to indicate the focus of the HIFU energy relative to the image of the tissue cross-section.FIG. 2 showsillustrative screen display 19 ofmonitor 18 wherein the outline T of the tissue, as imaged by imaging system 12., and a marker corresponding to the location of focal point F ofHIFU system 14, may be seen. - When activated, the HIFU system delivers ablative energy to the specific location shown on monitor 18 (focal point F in
FIG. 2 ), thus enabling safe creation of lesions or tissue welds. Because the HIFU system is configured to deliver energy from a number of sources focused towards the target tissue area, intervening tissue is subjected to only a fraction of the energy deposited in the target tissue receives, and thus the intervening tissue is not significantly heated or ablated. - Referring still to
FIG. 1 ,ultrasound imaging system 12 may be similar in design to previously-known trans-thoracic ultrasound imaging systems, and are per se known. High intensity focusedultrasound system 14 may comprise one ormore HIFU generators 20 constructed as described in U.S. Patent Publication No. US20010031922A1. As mentioned before,imaging system 12 andHIFU system 14 also may use common elements. Preferably, eachHIFU generator 20 is the same as or is disposed approximately in the same plane as the imaging elements ofultrasound imaging system 12, so that the focus ofHIFU system 14 occurs in the plane of the target tissue imaged byultrasound imaging system 12. In addition, this arrangement advantageously ensures that the HIFU energy will reach the target. - In a preferred embodiment,
HIFU generators 20 deliver energy at a frequency optimized for heating myocardium, so that the lesions created will weld, occlude, or lead to the occlusion of the patent foramen ovale. Once the lesions are created, a gradual healing process is begun in which the lesions fibrose, thus permanently sealing the opening. - While it may be possible to image and heat simultaneously, it may occur that the output of
HIFU system 14 may interfere with the ability to image the tissue usingultrasound imaging system 12. Accordingly,controller 16 may be programmed to time-gate operation ofimaging system 12 andHIFU system 14, so that the tissue is alternately imaged and ablated at a frequency of up to several times per second. - In order to apply energy to the wall of the septa of the heart sufficient to occlude the PFO, it may be desirable to slowly move the focus of the HIFU system along the wall of the septa during the ablation process. While this may be accomplished by manually moving the HIFU system, it may alternatively be desirable to automate the process. For example,
controller 16 may include suitable programming and joystick 22, or other input device, for refocusing the focal point ofHIFU system 14 along a desired trajectory. - Referring now to
FIG. 3 , according to an aspect of the present invention, an exemplary method of using the HIFU system to treat PFO is described. More particularly, the HIFU system is used to create localized tissue heating of the septum primum and septum secundum that will lead to occlusion of a PFO. The consequent healing process is expected to cause the septum primum and septum secundum to heal together, thereby permanently closing the PFO or resulting in acute welding of the tissues. Even if this non-invasive treatment were to be effective in closing PFO in only a small percentage of cases, the procedure would likely become the first choice for use in initial therapy. - The tissues of the septum primum and the septum secundum preferably are in contact when the energy is applied to facilitate welding of the PFO. In cases where heat is applied to cause closure through scar formation and subsequent healing, it is also desirable to have the tissue in apposition to ensure that the correct target tissues are heated to an adequate degree to cause tissue damage. Adequate apposition exists in many patients in the absence of an elevated right atrial pressure. However, in some cases it may be necessary or desirable to artificially increase the pressure gradient between the right and left atria to ensure closure of the PFO and/or to increase the contact pressure between the septum primum and septum secundum.
- Closure of the PFO or increased contact pressure between the septum primum and septum secundum can be achieved noninvasively through a variety of known techniques using medications, mechanical expedients, or a combination of the two. By way of example, briefly applying external pressure to a patient's jugular veins will temporarily limit blood flow into the superior vena cava and hence the right atrium. Of course, this lowers the right atrial pressure relative to the left atrial pressure, thereby creating the desired closure or increase in contact pressure. Alternatively, the desired closure or increase in contact pressure may be achieved by administering drugs that increase the patient's blood pressure by increasing heart rate and/or peripheral resistance. One suitable drug for increasing heart rate is epinephrine. As a further alternative, such drugs may be administered in combination with the application of pressure to the patient's jugular veins.
- In the system shown in
FIG. 3 the focus of the HIFU system is fixed at a certain point within the field of the ultrasound image. For example, the ultrasound image might show a picture of rectangular planar cross-section of tissue with a fixed focus of the HIFU energy in the center of the field. In operation, the clinician manually moves the probe until the desired tissue is in the target area, and then fires the HIFU system to ablate the tissue and occlude or weld the PFO. In order to ablate tissue located less than 130 mm below the skin and still retain a continuous fluid path from the probe to the target, the HIFU system includes fluid-filledballoon 24 that covers the face of the probe. -
Balloon 24 preferably is filled with water and enables the clinician to reposition the probe at a variable distance from the skin.Balloon 24 also permits the clinician to position the probe at any desired angle to target tissue not aligned directly under the focal point ofHIFU system 14. Alternatively, the patient could sit in a tub of water, so the patient's chest and the probe were both underwater, again ensuring a continuous fluid path. - As a further alternative,
controller 16 may be programmed so that the depth of the focal point of the HIFU system is depth-adjustable relative to the imaged tissue. Advantageously, the depth of the targeted tissue then could be adjusted relative to the imaged field, so a smaller fluid-filled balloon, or no balloon, is used to maintain fluid contact while adjusting the angle of the imaged section or make minor changes in the depth of the targeted tissue. WIPO Patent Publication No. WO/0145550A2 to Therus describes several ways to adjust the depth of the focused energy by changing the radius of curvature of one or more of the ultrasound generators. Alternatively, the direction of several focused energy generators of relatively fixed focal length could be shifted relative to one another to move the focal point. - In accordance with the principles of the present invention, focused energy is applied from outside the patient's body. Because ultrasound energy does not travel coherently through non-fluid filled tissue, such as the lungs, positioning of the ultrasound imaging system and HIFU system at certain angles may be more advantageous for treatment of specific areas of the heart.
- Accordingly, it may be desirable to locate the imaging system and HIFU system on a movable arm or to position it by hand so as to permit other external approaches, such as from below the diaphragm on the left anterior side of the body, so the ultrasound has a coherent path through the diaphragm and apex and ventricles of the heart to the septa. Application of the probe also may be made along a patient's back.
- While in the preferred embodiment described hereinabove energy is delivered from outside the body, situations may arise where it is difficult to deliver the energy to the PFO tissue. Referring now to
FIG. 4 , and in accordance with another aspect of the present invention, methods and apparatus are provided for positioning a probe inside the body and closer to the targeted tissue, but still not necessarily adjacent to it.Intraluminal probe 30 is configured to deliver HIFU energy to the heart from the esophagus, from the aorta, or from the great veins of the heart such as the inferior vena cava, superior vena cava, or the right atrium itself. - This approach is fundamentally different from previously-known methods of performing ablation during surgical procedures using epicardial probes or during interventional procedures using intracardiac ablation catheters. These previously-known devices are designed to be in direct contact or at least very close proximity (e.g., within 5 mm) of the target tissue, and are not designed to avoid ablation of intervening tissue between the probe and the target tissue.
- Still referring to
FIG. 4 ,catheter 30 preferably has a diameter in a range of 5 to 10 mm for vascular devices, and a diameter in a range of 5 to 20 mm for an esophageal device.Imaging elements 32 andHIFU elements 34 are arranged linearly along the longitudinal axis of the catheter. - The linear nature of the imaging element and HIFU element array may impose limitations on the ability to reposition the device. While translation and rotation of the catheter may be relatively easy, it is contemplated that it may be difficult to move the device very far to one side or another within a relatively small-diameter body lumen.
- Accordingly,
intraluminal catheter 30 preferably is configured to adjust the focal point of the HIFU system with respect to both longitudinal position and depth. This may be accomplished by programming the controller used withintraluminal catheter 30 to adjust the focal point of the HIFU system, as described above. Alternatively, refocusing of the array of HIFU elements may be achieved by locating individual HIFU elements on independentlysteerable actuators 36.Actuators 36 are controlled by the system controller and permit the clinician to move the focal point of the HIFU array to any desired point in the field of view of the imaging system. - In accordance with another aspect of the present invention, methods of using
intraluminal catheter 30 to heat or ablate septal tissues from the esophagus to treat PFO are described. The esophagus is separated from the PFO by only about 20-25 mm, such that a lesion may be easily made in the PFO using a probe capable of delivering energy at a distance of approximately 20-50 mm. - As described above,
intraluminal catheter 30 preferably is configured, either mechanically or by suitable software algorithms, to move its focal point to enable a continuous linear ablation or heat affected zone without moving the device. Alternatively, the HIFU array of the catheter may be configured to create a linear ablation or heat affected zone, or have a fixed-focus so that a linear ablation or heat affected zone may be created by translating the HIFU array within the esophagus. - In addition, it may be beneficial to cool tissue surrounding the HIFU array of
intraluminal catheter 30, to further reduce the risk of damage to the esophagus.Intraluminal catheter 30 may therefore include a water jacket that circulates fluid around the HIFU array to prevent any heat generated by the array or ultrasound energy absorbed by the esophagus from causing any tissue damage. - Although preferred illustrative embodiments of the present invention are described above, it will be evident to one skilled in the art that various changes and modifications may be made without departing from the invention. It is intended in the appended claims to cover all such changes and modifications that fall within the true spirit and scope of the invention.
Claims (14)
1. An apparatus for non-invasively treating patent foramen ovale comprising:
a housing;
an ultrasound imaging system disposed within the housing;
a high intensity focused ultrasound system disposed within the housing in alignment with the ultrasound imaging system;
a controller operably connected to the ultrasound imaging system and high intensity focused ultrasound system to selectively target high intensity ultrasound energy on either or both of a patient's septum primum or septum secundum; and
a fluid-filled balloon coupled to the housing to adjust a location of a focal point of the high intensity focused ultrasound system.
2. The apparatus of claim 1 , wherein the patient's septum primum and septum secundum are apposed during treatment.
3. The apparatus of claim 2 , wherein apposition of the patient's septum primum and septum secundum is achieved noninvasively using drugs, noninvasive procedures, or a combination thereof.
4. The apparatus of claim 2 , wherein increased contact pressure between the patient's septum primum and septum secundum is achieved noninvasively using drugs, noninvasive procedures, or a combination thereof.
5. The apparatus of claim 1 , wherein the housing is adapted to apply energy to either or both of the septum primum or septum secundum from outside a patient's body.
6. A method of non-invasively treating patent foramen ovale comprising:
providing a housing having an ultrasound imaging system and a high intensity focused ultrasound system disposed in alignment with the ultrasound imaging system;
contacting the housing against a patient's body; and
operating the ultrasound imaging system to generate an image of a portion of cardiac tissue; and operating the high intensity focused ultrasound system, guided by the image, to heat or ablate either or both of a patient's septum primum or septum secundum.
7. The method of claim 6 , further comprising generating and displaying a marker corresponding to a focal point of the high intensity focused ultrasound system on the image.
8. The method of claim 6 , further comprising modifying a location of the target site by adjusting a location of a focal point of the high intensity focused ultrasound system.
9. The method of claim 6 , further comprising disposing a fluid-filled balloon between the patient's body and the housing to adjust a location of a focal point of the high intensity focused ultrasound system.
10. The method of claim 6 , further comprising apposing the patient's septum primum and septum secundum noninvasively using drugs, noninvasive procedures, or a combination thereof.
11. The method of claim 6 , further comprising increasing contact pressure between the patient's septum primum and septum secundum is noninvasively using drugs, noninvasive procedures, or a combination thereof.
12. The method of claim 6 , wherein contacting comprises engaging the housing on an outside surface of the patient's body.
13. The method of claim 6 , wherein contacting comprises engaging the housing on an esophageal surface of the patient's body.
14. The method of claim 6 , wherein contacting the housing comprises introducing the housing in a patient's heart chamber.
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US11/934,891 US20080058683A1 (en) | 2003-06-10 | 2007-11-05 | Method and apparatus for non-invasively treating patent foramen ovale using high intensity focused ultrasound |
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US11/934,891 US20080058683A1 (en) | 2003-06-10 | 2007-11-05 | Method and apparatus for non-invasively treating patent foramen ovale using high intensity focused ultrasound |
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US11/494,387 Expired - Fee Related US9302125B2 (en) | 2003-06-10 | 2006-07-26 | Methods and apparatus for non-invasively treating atrial fibrillation using high intensity focused ultrasound |
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Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070027445A1 (en) * | 2003-06-10 | 2007-02-01 | Gifford Hanson S | Methods and apparatus for non-invasively treating patent foramen ovale using high intensity focused ultrasound |
US20080221448A1 (en) * | 2007-03-07 | 2008-09-11 | Khuri-Yakub Butrus T | Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions |
US20090005776A1 (en) * | 2007-06-25 | 2009-01-01 | Terumo Kabushiki Kaisha | Medical device |
US20090069810A1 (en) * | 2007-08-28 | 2009-03-12 | Terumo Kabushiki Kaisha | Biological tissue closing device |
US20090069809A1 (en) * | 2007-08-28 | 2009-03-12 | Terumo Kabushiki Kaisha | Pfo closing device |
US20090076525A1 (en) * | 2007-08-28 | 2009-03-19 | Terumo Kabushiki Kaisha | Pfo closing device |
US20090240146A1 (en) * | 2007-10-26 | 2009-09-24 | Liposonix, Inc. | Mechanical arm |
US20100036292A1 (en) * | 2008-08-06 | 2010-02-11 | Mirabilis Medica Inc. | Optimization and feedback control of hifu power deposition through the analysis of detected signal characteristics |
US20100106019A1 (en) * | 2008-10-24 | 2010-04-29 | Mirabilis Medica, Inc. | Method and apparatus for feedback control of hifu treatments |
US20110092880A1 (en) * | 2009-10-12 | 2011-04-21 | Michael Gertner | Energetic modulation of nerves |
US20110092781A1 (en) * | 2009-10-12 | 2011-04-21 | Michael Gertner | Energetic modulation of nerves |
US20110118600A1 (en) * | 2009-11-16 | 2011-05-19 | Michael Gertner | External Autonomic Modulation |
US20110118598A1 (en) * | 2009-10-12 | 2011-05-19 | Michael Gertner | Targeted Inhibition of Physiologic and Pathologic Processes |
US20110257561A1 (en) * | 2009-10-12 | 2011-10-20 | Kona Medical, Inc. | Energetic modulation of nerves |
WO2011123862A3 (en) * | 2010-04-02 | 2012-03-08 | Mirabilis Medica, Inc. | Office-based system for treating uterine fibroids or other tissues with hifu |
US20120065494A1 (en) * | 2009-10-12 | 2012-03-15 | Kona Medical, Inc. | Energetic modulation of nerves |
US8172839B2 (en) | 2006-02-24 | 2012-05-08 | Terumo Kabushiki Kaisha | PFO closing device |
US8394090B2 (en) | 2007-06-25 | 2013-03-12 | Terumo Kabushiki Kaisha | Medical device |
US8469904B2 (en) | 2009-10-12 | 2013-06-25 | Kona Medical, Inc. | Energetic modulation of nerves |
CN103236213A (en) * | 2013-04-19 | 2013-08-07 | 上海交通大学 | Atrial fibrillation catheter ablation simulation based on optical binocular positioning |
US8517962B2 (en) | 2009-10-12 | 2013-08-27 | Kona Medical, Inc. | Energetic modulation of nerves |
US8845559B2 (en) | 2008-10-03 | 2014-09-30 | Mirabilis Medica Inc. | Method and apparatus for treating tissues with HIFU |
US8992447B2 (en) | 2009-10-12 | 2015-03-31 | Kona Medical, Inc. | Energetic modulation of nerves |
US9573000B2 (en) | 2010-08-18 | 2017-02-21 | Mirabilis Medica Inc. | HIFU applicator |
US20170325880A1 (en) * | 2009-10-12 | 2017-11-16 | Kona Medical, Inc. | Energy delivery to intraparenchymal regions of the kidney |
US10925579B2 (en) | 2014-11-05 | 2021-02-23 | Otsuka Medical Devices Co., Ltd. | Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7713190B2 (en) | 1998-02-24 | 2010-05-11 | Hansen Medical, Inc. | Flexible instrument |
AU2002333102A1 (en) * | 2002-02-22 | 2003-09-09 | Bombardier Inc. | A three-wheeled vehicle having a split radiator and an interior storage compartment |
US20040082859A1 (en) | 2002-07-01 | 2004-04-29 | Alan Schaer | Method and apparatus employing ultrasound energy to treat body sphincters |
US8021359B2 (en) | 2003-02-13 | 2011-09-20 | Coaptus Medical Corporation | Transseptal closure of a patent foramen ovale and other cardiac defects |
US7165552B2 (en) | 2003-03-27 | 2007-01-23 | Cierra, Inc. | Methods and apparatus for treatment of patent foramen ovale |
US7293562B2 (en) | 2003-03-27 | 2007-11-13 | Cierra, Inc. | Energy based devices and methods for treatment of anatomic tissue defects |
JP4382087B2 (en) | 2003-03-27 | 2009-12-09 | テルモ株式会社 | Method and apparatus for treatment of patent foramen ovale |
US6939348B2 (en) * | 2003-03-27 | 2005-09-06 | Cierra, Inc. | Energy based devices and methods for treatment of patent foramen ovale |
US7883506B2 (en) * | 2004-11-08 | 2011-02-08 | Boston Scientific Scimed, Inc. | Devices and methods for the treatment of endometriosis |
WO2006087649A1 (en) * | 2005-02-17 | 2006-08-24 | Koninklijke Philips Electronics, N.V. | Method and apparatus for the visualization of the focus generated using focused ultrasound |
US20060229597A1 (en) * | 2005-04-07 | 2006-10-12 | Mcintyre Jon T | Ultrasound medical device and related methods of use |
US7824397B2 (en) * | 2005-08-19 | 2010-11-02 | Boston Scientific Scimed, Inc. | Occlusion apparatus |
US7837619B2 (en) * | 2005-08-19 | 2010-11-23 | Boston Scientific Scimed, Inc. | Transeptal apparatus, system, and method |
US8062309B2 (en) * | 2005-08-19 | 2011-11-22 | Boston Scientific Scimed, Inc. | Defect occlusion apparatus, system, and method |
US7998095B2 (en) * | 2005-08-19 | 2011-08-16 | Boston Scientific Scimed, Inc. | Occlusion device |
US20070106214A1 (en) * | 2005-10-17 | 2007-05-10 | Coaptus Medical Corporation | Systems and methods for securing cardiovascular tissue, including via asymmetric inflatable members |
SG132553A1 (en) * | 2005-11-28 | 2007-06-28 | Pang Ah San | A device for laparoscopic or thoracoscopic surgery |
US20070142699A1 (en) * | 2005-12-16 | 2007-06-21 | Acoustx Corporation | Methods and implantable apparatuses for treating an esophageal disorder such as gastroesophageal reflux disease |
US20070142884A1 (en) * | 2005-12-16 | 2007-06-21 | Acoustx Corporation | Methods and apparatuses for treating an esophageal disorder such as gastroesophageal reflux disease |
WO2007084508A2 (en) | 2006-01-13 | 2007-07-26 | Mirabilis Medica, Inc. | Apparatus for delivering high intensity focused ultrasound energy to a treatment site internal to a patient's body |
CA2649119A1 (en) | 2006-04-13 | 2007-12-13 | Mirabilis Medica, Inc. | Methods and apparatus for the treatment of menometrorrhagia, endometrial pathology, and cervical neoplasia using high intensity focused ultrasound energy |
WO2007134258A2 (en) * | 2006-05-12 | 2007-11-22 | Vytronus, Inc. | Device for ablating body tissue |
US10499937B2 (en) | 2006-05-19 | 2019-12-10 | Recor Medical, Inc. | Ablation device with optimized input power profile and method of using the same |
CN101490548A (en) * | 2006-06-02 | 2009-07-22 | 哈佛大学校长及研究员协会 | Protein surface remodeling |
WO2007143574A1 (en) | 2006-06-02 | 2007-12-13 | President And Fellows Of Harvard College | Protein surface remodeling |
US20090297455A1 (en) * | 2006-08-09 | 2009-12-03 | Koninklijke Philips Electronics N.V. | Device for and a method of activating a physiologically effective substance by ultrasonic waves, and a capsule |
US20080071173A1 (en) * | 2006-09-18 | 2008-03-20 | Aldrich William N | Visualizing Formation of Ablation Lesions |
US20080140113A1 (en) * | 2006-12-07 | 2008-06-12 | Cierra, Inc. | Method for sealing a pfo using an energy delivery device |
US8052604B2 (en) | 2007-07-31 | 2011-11-08 | Mirabilis Medica Inc. | Methods and apparatus for engagement and coupling of an intracavitory imaging and high intensity focused ultrasound probe |
US8439907B2 (en) | 2007-11-07 | 2013-05-14 | Mirabilis Medica Inc. | Hemostatic tissue tunnel generator for inserting treatment apparatus into tissue of a patient |
US8187270B2 (en) | 2007-11-07 | 2012-05-29 | Mirabilis Medica Inc. | Hemostatic spark erosion tissue tunnel generator with integral treatment providing variable volumetric necrotization of tissue |
EP2240081A1 (en) * | 2007-12-21 | 2010-10-20 | Koninklijke Philips Electronics N.V. | Systems and methods for tracking and guiding high intensity focused ultrasound beams |
JP5181791B2 (en) * | 2008-04-03 | 2013-04-10 | ソニー株式会社 | Voltage controlled variable frequency oscillation circuit and signal processing circuit |
US20090259128A1 (en) * | 2008-04-14 | 2009-10-15 | Stribling Mark L | Moveable ultrasound elements for use in medical diagnostic equipment |
US9155588B2 (en) | 2008-06-13 | 2015-10-13 | Vytronus, Inc. | System and method for positioning an elongate member with respect to an anatomical structure |
US20100152582A1 (en) * | 2008-06-13 | 2010-06-17 | Vytronus, Inc. | Handheld system and method for delivering energy to tissue |
WO2009152354A1 (en) * | 2008-06-14 | 2009-12-17 | Vytronus, Inc. | System and method for delivering energy to tissue |
US20100049099A1 (en) * | 2008-07-18 | 2010-02-25 | Vytronus, Inc. | Method and system for positioning an energy source |
US10363057B2 (en) | 2008-07-18 | 2019-07-30 | Vytronus, Inc. | System and method for delivering energy to tissue |
US8216161B2 (en) | 2008-08-06 | 2012-07-10 | Mirabilis Medica Inc. | Optimization and feedback control of HIFU power deposition through the frequency analysis of backscattered HIFU signals |
US9033885B2 (en) * | 2008-10-30 | 2015-05-19 | Vytronus, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US9192789B2 (en) | 2008-10-30 | 2015-11-24 | Vytronus, Inc. | System and method for anatomical mapping of tissue and planning ablation paths therein |
US9220924B2 (en) | 2008-10-30 | 2015-12-29 | Vytronus, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US8414508B2 (en) | 2008-10-30 | 2013-04-09 | Vytronus, Inc. | System and method for delivery of energy to tissue while compensating for collateral tissue |
US11298568B2 (en) | 2008-10-30 | 2022-04-12 | Auris Health, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US8475379B2 (en) * | 2008-11-17 | 2013-07-02 | Vytronus, Inc. | Systems and methods for ablating body tissue |
JP5941281B2 (en) | 2008-11-17 | 2016-06-29 | バイトロナス, インコーポレイテッド | System and method for ablating body tissue |
WO2010080886A1 (en) | 2009-01-09 | 2010-07-15 | Recor Medical, Inc. | Methods and apparatus for treatment of mitral valve in insufficiency |
US9221886B2 (en) | 2009-04-28 | 2015-12-29 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
KR101143645B1 (en) * | 2009-07-29 | 2012-05-09 | 주세은 | Transcranial low-intensity ultrasound delivery device and non-invasive modulation of brain function |
WO2011127216A2 (en) | 2010-04-06 | 2011-10-13 | Innovative Pulmonary Solutions, Inc. | System and method for pulmonary treatment |
US8617150B2 (en) | 2010-05-14 | 2013-12-31 | Liat Tsoref | Reflectance-facilitated ultrasound treatment |
US9242122B2 (en) | 2010-05-14 | 2016-01-26 | Liat Tsoref | Reflectance-facilitated ultrasound treatment and monitoring |
US8956346B2 (en) | 2010-05-14 | 2015-02-17 | Rainbow Medical, Ltd. | Reflectance-facilitated ultrasound treatment and monitoring |
CN104160423A (en) * | 2012-02-02 | 2014-11-19 | 华盛顿大学商业中心 | Filtering systems and methods for suppression of non-stationary reverberation in ultrasound images |
US9707414B2 (en) | 2012-02-14 | 2017-07-18 | Rainbow Medical Ltd. | Reflectance-facilitated ultrasound treatment and monitoring |
US9770593B2 (en) | 2012-11-05 | 2017-09-26 | Pythagoras Medical Ltd. | Patient selection using a transluminally-applied electric current |
US10004557B2 (en) | 2012-11-05 | 2018-06-26 | Pythagoras Medical Ltd. | Controlled tissue ablation |
EP3139853B1 (en) | 2014-05-07 | 2018-12-19 | Pythagoras Medical Ltd. | Controlled tissue ablation apparatus |
JP6727286B2 (en) * | 2015-04-02 | 2020-07-22 | カーディアウェイブ | Method and apparatus for treating pericardial disease |
US10383685B2 (en) | 2015-05-07 | 2019-08-20 | Pythagoras Medical Ltd. | Techniques for use with nerve tissue |
KR20240032165A (en) * | 2015-08-10 | 2024-03-08 | 퍼스모바일 인코포레이티드 | Image guided focused ultrasound treatment device and aiming apparatus |
EP3367943B1 (en) * | 2015-10-30 | 2021-02-24 | Georgia Tech Research Corporation | Foldable 2-d cmut-on-cmos arrays |
US11678932B2 (en) | 2016-05-18 | 2023-06-20 | Symap Medical (Suzhou) Limited | Electrode catheter with incremental advancement |
US10300308B2 (en) * | 2016-09-23 | 2019-05-28 | SonaCare Medical, LLC | System, apparatus and method for high-intensity focused ultrasound (HIFU) and/or ultrasound delivery while protecting critical structures |
CN110997066B (en) * | 2017-06-21 | 2022-08-05 | 香港理工大学 | Apparatus and method for ultrasonic spinal cord stimulation |
AU2020232595A1 (en) | 2019-03-01 | 2021-09-16 | Rampart Health, L.L.C. | Pharmaceutical composition combining immunologic and chemotherapeutic method for the treatment of cancer |
WO2021081105A1 (en) * | 2019-10-21 | 2021-04-29 | University Of Virginia Patent Foundation | Methods, systems, and computer readable media for utilizing a therapeutic ultrasound device to perform mitral valve decalcification |
IL305126A (en) | 2021-02-12 | 2023-10-01 | Rampart Health L L C | Therapeutic composition and method combining multiplex immunotherapy with cancer vaccine for the treatment of cancer |
Citations (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2275167A (en) * | 1939-04-26 | 1942-03-03 | Bierman William | Electrosurgical instrument |
US2580628A (en) * | 1950-07-12 | 1952-01-01 | Bowen & Company Inc | Suction electrode |
US3490442A (en) * | 1966-02-09 | 1970-01-20 | Hellige & Co Gmbh F | Electrode with contact-forming suction cup means |
US3862627A (en) * | 1973-08-16 | 1975-01-28 | Sr Wendel J Hans | Suction electrode |
US3874388A (en) * | 1973-02-12 | 1975-04-01 | Ochsner Med Found Alton | Shunt defect closure system |
US4326529A (en) * | 1978-05-26 | 1982-04-27 | The United States Of America As Represented By The United States Department Of Energy | Corneal-shaping electrode |
US4562838A (en) * | 1981-01-23 | 1986-01-07 | Walker William S | Electrosurgery instrument |
US4798594A (en) * | 1987-09-21 | 1989-01-17 | Cordis Corporation | Medical instrument valve |
US4832048A (en) * | 1987-10-29 | 1989-05-23 | Cordis Corporation | Suction ablation catheter |
US4895565A (en) * | 1987-09-21 | 1990-01-23 | Cordis Corporation | Medical instrument valve |
US4911159A (en) * | 1988-11-21 | 1990-03-27 | Johnson Jeffrey W | Electrosurgical instrument with electrical contacts between the probe and the probe holder |
US4919129A (en) * | 1987-11-30 | 1990-04-24 | Celebration Medical Products, Inc. | Extendable electrocautery surgery apparatus and method |
US4929246A (en) * | 1988-10-27 | 1990-05-29 | C. R. Bard, Inc. | Method for closing and sealing an artery after removing a catheter |
US4986889A (en) * | 1988-12-23 | 1991-01-22 | Societe Des Techniques En Milieu Ionisant Stmi | Suction cup for the electrolytic treatment of a surface |
US5078717A (en) * | 1989-04-13 | 1992-01-07 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US5099827A (en) * | 1989-12-13 | 1992-03-31 | Richard Wolf Gmbh | Instrument set for closing opened body organs, wounds or the like |
US5196007A (en) * | 1991-06-07 | 1993-03-23 | Alan Ellman | Electrosurgical handpiece with activator |
US5195959A (en) * | 1991-05-31 | 1993-03-23 | Paul C. Smith | Electrosurgical device with suction and irrigation |
US5197963A (en) * | 1991-12-02 | 1993-03-30 | Everest Medical Corporation | Electrosurgical instrument with extendable sheath for irrigation and aspiration |
US5207670A (en) * | 1990-06-15 | 1993-05-04 | Rare Earth Medical, Inc. | Photoreactive suturing of biological materials |
US5209756A (en) * | 1989-11-03 | 1993-05-11 | Bahaa Botros Seedhom | Ligament fixation staple |
US5290278A (en) * | 1992-10-20 | 1994-03-01 | Proclosure Inc. | Method and apparatus for applying thermal energy to luminal tissue |
US5292362A (en) * | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
US5295955A (en) * | 1992-02-14 | 1994-03-22 | Amt, Inc. | Method and apparatus for microwave aided liposuction |
US5300065A (en) * | 1992-11-06 | 1994-04-05 | Proclosure Inc. | Method and apparatus for simultaneously holding and sealing tissue |
US5380304A (en) * | 1991-08-07 | 1995-01-10 | Cook Incorporated | Flexible, kink-resistant, introducer sheath and method of manufacture |
US5383917A (en) * | 1991-07-05 | 1995-01-24 | Jawahar M. Desai | Device and method for multi-phase radio-frequency ablation |
US5405322A (en) * | 1993-08-12 | 1995-04-11 | Boston Scientific Corporation | Method for treating aneurysms with a thermal source |
US5409481A (en) * | 1992-05-21 | 1995-04-25 | Laserscope | Laser tissue welding control system |
US5409479A (en) * | 1983-10-06 | 1995-04-25 | Premier Laser Systems, Inc. | Method for closing tissue wounds using radiative energy beams |
US5500012A (en) * | 1992-07-15 | 1996-03-19 | Angeion Corporation | Ablation catheter system |
US5505730A (en) * | 1994-06-24 | 1996-04-09 | Stuart D. Edwards | Thin layer ablation apparatus |
US5507744A (en) * | 1992-04-23 | 1996-04-16 | Scimed Life Systems, Inc. | Apparatus and method for sealing vascular punctures |
US5611794A (en) * | 1990-10-11 | 1997-03-18 | Lasersurge, Inc. | Clamp for approximating tissue sections |
US5620481A (en) * | 1991-07-05 | 1997-04-15 | Desai; Jawahar M. | Device for multi-phase radio-frequency ablation |
US5626607A (en) * | 1995-04-03 | 1997-05-06 | Heartport, Inc. | Clamp assembly and method of use |
US5709224A (en) * | 1995-06-07 | 1998-01-20 | Radiotherapeutics Corporation | Method and device for permanent vessel occlusion |
US5725522A (en) * | 1990-06-15 | 1998-03-10 | Rare Earth Medical, Inc. | Laser suturing of biological materials |
US5730742A (en) * | 1994-08-04 | 1998-03-24 | Alto Development Corporation | Inclined, flared, thermally-insulated, anti-clog tip for electrocautery suction tubes |
US5749895A (en) * | 1991-02-13 | 1998-05-12 | Fusion Medical Technologies, Inc. | Method for bonding or fusion of biological tissue and material |
US5855312A (en) * | 1996-07-25 | 1999-01-05 | Toledano; Haviv | Flexible annular stapler for closed surgery of hollow organs |
US5871443A (en) * | 1992-09-25 | 1999-02-16 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
US6036699A (en) * | 1992-12-10 | 2000-03-14 | Perclose, Inc. | Device and method for suturing tissue |
US6056760A (en) * | 1997-01-30 | 2000-05-02 | Nissho Corporation | Device for intracardiac suture |
US6063085A (en) * | 1992-04-23 | 2000-05-16 | Scimed Life Systems, Inc. | Apparatus and method for sealing vascular punctures |
US6063081A (en) * | 1995-02-22 | 2000-05-16 | Medtronic, Inc. | Fluid-assisted electrocautery device |
US6168594B1 (en) * | 1992-11-13 | 2001-01-02 | Scimed Life Systems, Inc. | Electrophysiology RF energy treatment device |
US6211335B1 (en) * | 1995-01-20 | 2001-04-03 | The Microsearch Foundation Of Australia | Method of tissue repair |
US6221068B1 (en) * | 1998-01-15 | 2001-04-24 | Northwestern University | Method for welding tissue |
US6236875B1 (en) * | 1994-10-07 | 2001-05-22 | Surgical Navigation Technologies | Surgical navigation systems including reference and localization frames |
US6355030B1 (en) * | 1998-09-25 | 2002-03-12 | Cardiothoracic Systems, Inc. | Instruments and methods employing thermal energy for the repair and replacement of cardiac valves |
US6375668B1 (en) * | 1999-06-02 | 2002-04-23 | Hanson S. Gifford | Devices and methods for treating vascular malformations |
US6383198B1 (en) * | 1999-12-07 | 2002-05-07 | Scimed Life System, Inc. | Flexible vacuum grabber for holding lesions |
US6391049B1 (en) * | 1999-10-06 | 2002-05-21 | Board Of Regents The University Of Texas System | Solid biodegradable device for use in tissue repair |
US6391048B1 (en) * | 2000-01-05 | 2002-05-21 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant and methods of use |
US6514250B1 (en) * | 2000-04-27 | 2003-02-04 | Medtronic, Inc. | Suction stabilized epicardial ablation devices |
US20030028189A1 (en) * | 1998-08-11 | 2003-02-06 | Arthrocare Corporation | Systems and methods for electrosurgical tissue treatment |
US20030045893A1 (en) * | 2001-09-06 | 2003-03-06 | Integrated Vascular Systems, Inc. | Clip apparatus for closing septal defects and methods of use |
US20030045901A1 (en) * | 2001-09-06 | 2003-03-06 | Nmt Medical, Inc. | Flexible delivery system |
US20030050665A1 (en) * | 2001-09-07 | 2003-03-13 | Integrated Vascular Systems, Inc. | Needle apparatus for closing septal defects and methods for using such apparatus |
US20030065364A1 (en) * | 2001-09-28 | 2003-04-03 | Ethicon, Inc. | Expandable intracardiac return electrode and method of use |
US20030069570A1 (en) * | 1999-10-02 | 2003-04-10 | Witzel Thomas H. | Methods for repairing mitral valve annulus percutaneously |
US20030078578A1 (en) * | 2001-10-22 | 2003-04-24 | Csaba Truckai | Electrosurgical instrument and method of use |
US6558314B1 (en) * | 2000-02-11 | 2003-05-06 | Iotek, Inc. | Devices and method for manipulation of organ tissue |
US6558382B2 (en) * | 2000-04-27 | 2003-05-06 | Medtronic, Inc. | Suction stabilized epicardial ablation devices |
US6562037B2 (en) * | 1998-02-12 | 2003-05-13 | Boris E. Paton | Bonding of soft biological tissues by passing high frequency electric current therethrough |
US20030092988A1 (en) * | 2001-05-29 | 2003-05-15 | Makin Inder Raj S. | Staging medical treatment using ultrasound |
US20030093071A1 (en) * | 2001-11-15 | 2003-05-15 | Hauck Wallace N. | Cardiac valve leaflet stapler device and methods thereof |
US6676685B2 (en) * | 1999-02-22 | 2004-01-13 | Tyco Healthcare Group Lp | Arterial hole closure apparatus |
US6682546B2 (en) * | 1994-07-08 | 2004-01-27 | Aga Medical Corporation | Intravascular occlusion devices |
US6692450B1 (en) * | 2000-01-19 | 2004-02-17 | Medtronic Xomed, Inc. | Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same |
US6712836B1 (en) * | 1999-05-13 | 2004-03-30 | St. Jude Medical Atg, Inc. | Apparatus and methods for closing septal defects and occluding blood flow |
US6712804B2 (en) * | 1999-09-20 | 2004-03-30 | Ev3 Sunnyvale, Inc. | Method of closing an opening in a wall of the heart |
US6726718B1 (en) * | 1999-12-13 | 2004-04-27 | St. Jude Medical, Inc. | Medical articles prepared for cell adhesion |
US6730108B2 (en) * | 1999-10-27 | 2004-05-04 | Atritech, Inc. | Barrier device for ostium of left atrial appendage |
US6733498B2 (en) * | 2002-02-19 | 2004-05-11 | Live Tissue Connect, Inc. | System and method for control of tissue welding |
US20040092973A1 (en) * | 2002-09-23 | 2004-05-13 | Nmt Medical, Inc. | Septal puncture device |
US6736810B2 (en) * | 1998-07-07 | 2004-05-18 | Medtronic, Inc. | Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue |
US20040098042A1 (en) * | 2002-06-03 | 2004-05-20 | Devellian Carol A. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
US20040098031A1 (en) * | 1998-11-06 | 2004-05-20 | Van Der Burg Erik J. | Method and device for left atrial appendage occlusion |
US20040102721A1 (en) * | 2002-11-22 | 2004-05-27 | Mckinley Laurence M. | System, method and apparatus for locating, measuring and evaluating the enlargement of a foramen |
US6846319B2 (en) * | 2000-12-14 | 2005-01-25 | Core Medical, Inc. | Devices for sealing openings through tissue and apparatus and methods for delivering them |
US20050021059A1 (en) * | 2000-04-29 | 2005-01-27 | Cole David H. | Magnetic components for use in forming anastomoses, creating ports in vessels and closing openings in tissue |
US20050033288A1 (en) * | 2003-02-13 | 2005-02-10 | Coaptus Medical Corporation | Transseptal left atrial access and septal closure |
US20050033327A1 (en) * | 1999-09-07 | 2005-02-10 | John Gainor | Retrievable septal defect closure device |
US20050055050A1 (en) * | 2003-07-24 | 2005-03-10 | Alfaro Arthur A. | Intravascular occlusion device |
US20050065509A1 (en) * | 2003-09-22 | 2005-03-24 | Scimed Life Systems, Inc. | Flat electrode arrays for generating flat lesions |
US20050065506A1 (en) * | 2003-09-12 | 2005-03-24 | Scimed Life Systems, Inc. | Vacuum-based catheter stabilizer |
US20050070923A1 (en) * | 2003-09-26 | 2005-03-31 | Mcintosh Scott A. | Device and method for suturing intracardiac defects |
US20050075665A1 (en) * | 2003-09-19 | 2005-04-07 | St. Jude Medical, Inc. | Apparatus and methods for tissue gathering and securing |
US20060036284A1 (en) * | 2002-05-06 | 2006-02-16 | Velocimed, Llc | PFO closure devices and related methods of use |
US20060052821A1 (en) * | 2001-09-06 | 2006-03-09 | Ovalis, Inc. | Systems and methods for treating septal defects |
US20060069408A1 (en) * | 2004-09-29 | 2006-03-30 | Terumo Kabushiki Kaisha | Device for treating a patent foramen ovale |
US7165552B2 (en) * | 2003-03-27 | 2007-01-23 | Cierra, Inc. | Methods and apparatus for treatment of patent foramen ovale |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2888928A (en) | 1957-04-15 | 1959-06-02 | Seiger Harry Wright | Coagulating surgical instrument |
US3906955A (en) | 1974-05-06 | 1975-09-23 | Richard R Roberts | Surgical cauterizing tool having suction means |
US4307720A (en) | 1979-07-26 | 1981-12-29 | Weber Jr Jaroy | Electrocautery apparatus and method and means for cleaning the same |
US4485817A (en) | 1982-05-28 | 1984-12-04 | United States Surgical Corporation | Surgical stapler apparatus with flexible shaft |
US4473077A (en) | 1982-05-28 | 1984-09-25 | United States Surgical Corporation | Surgical stapler apparatus with flexible shaft |
US5370675A (en) | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
DE3374522D1 (en) * | 1982-10-26 | 1987-12-23 | University Of Aberdeen | |
DE3300765C1 (en) | 1983-01-12 | 1983-10-20 | Ingeborg Nieß Elektromedizinische Apparate, 7906 Blaustein | Electrode device for the reduction of electro-physiological voltages |
US4682596A (en) | 1984-05-22 | 1987-07-28 | Cordis Corporation | Electrosurgical catheter and method for vascular applications |
US4788975B1 (en) | 1987-11-05 | 1999-03-02 | Trimedyne Inc | Control system and method for improved laser angioplasty |
US4884567A (en) | 1987-12-03 | 1989-12-05 | Dimed Inc. | Method for transvenous implantation of objects into the pericardial space of patients |
US4858613A (en) * | 1988-03-02 | 1989-08-22 | Laboratory Equipment, Corp. | Localization and therapy system for treatment of spatially oriented focal disease |
US4976711A (en) | 1989-04-13 | 1990-12-11 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US5057107A (en) | 1989-04-13 | 1991-10-15 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US5125928A (en) | 1989-04-13 | 1992-06-30 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US5055100A (en) | 1989-06-19 | 1991-10-08 | Eugene Olsen | Suction attachment for electrosurgical instruments or the like |
US5056517A (en) | 1989-07-24 | 1991-10-15 | Consiglio Nazionale Delle Ricerche | Biomagnetically localizable multipurpose catheter and method for magnetocardiographic guided intracardiac mapping, biopsy and ablation of cardiac arrhythmias |
US5041095A (en) | 1989-12-22 | 1991-08-20 | Cordis Corporation | Hemostasis valve |
GB9008764D0 (en) | 1990-04-19 | 1990-06-13 | Egnell Ameda Ltd | A resilient suction cup |
US5171311A (en) | 1990-04-30 | 1992-12-15 | Everest Medical Corporation | Percutaneous laparoscopic cholecystectomy instrument |
US5071418A (en) | 1990-05-16 | 1991-12-10 | Joseph Rosenbaum | Electrocautery surgical scalpel |
US5540677A (en) | 1990-06-15 | 1996-07-30 | Rare Earth Medical, Inc. | Endoscopic systems for photoreactive suturing of biological materials |
DE4024106C1 (en) | 1990-07-30 | 1992-04-23 | Ethicon Gmbh & Co Kg, 2000 Norderstedt, De | |
US5042707A (en) | 1990-10-16 | 1991-08-27 | Taheri Syde A | Intravascular stapler, and method of operating same |
US5156613A (en) | 1991-02-13 | 1992-10-20 | Interface Biomedical Laboratories Corp. | Collagen welding rod material for use in tissue welding |
AU1444292A (en) | 1991-02-13 | 1992-09-15 | Interface Biomedical Laboratories Corp. | Filler material for use in tissue welding |
US5669934A (en) | 1991-02-13 | 1997-09-23 | Fusion Medical Technologies, Inc. | Methods for joining tissue by applying radiofrequency energy to performed collagen films and sheets |
US20010051803A1 (en) * | 1991-07-05 | 2001-12-13 | Desai Jawahar M. | Device and method for multi-phase radio-frequency ablation |
WO1993019705A1 (en) * | 1992-03-31 | 1993-10-14 | Massachusetts Institute Of Technology | Apparatus and method for acoustic heat generation and hyperthermia |
US5295484A (en) * | 1992-05-19 | 1994-03-22 | Arizona Board Of Regents For And On Behalf Of The University Of Arizona | Apparatus and method for intra-cardiac ablation of arrhythmias |
SE9201600L (en) | 1992-05-21 | 1993-11-22 | Siemens Elema Ab | The electrode device |
US5324284A (en) | 1992-06-05 | 1994-06-28 | Cardiac Pathways, Inc. | Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method |
US5336252A (en) | 1992-06-22 | 1994-08-09 | Cohen Donald M | System and method for implanting cardiac electrical leads |
US5336221A (en) | 1992-10-14 | 1994-08-09 | Premier Laser Systems, Inc. | Method and apparatus for applying thermal energy to tissue using a clamp |
DE4302537C1 (en) * | 1993-01-29 | 1994-04-28 | Siemens Ag | Ultrasound imaging and therapy device - generates imaging waves and focussed treatment waves having two differing frequencies for location and treatment of e.g tumours |
WO1994023793A1 (en) * | 1993-04-15 | 1994-10-27 | Siemens Aktiengesellschaft | Therapeutic appliance for the treatment of conditions of the heart and of blood vessels in the vicinity of the heart |
US5571088A (en) | 1993-07-01 | 1996-11-05 | Boston Scientific Corporation | Ablation catheters |
US5571216A (en) | 1994-01-19 | 1996-11-05 | The General Hospital Corporation | Methods and apparatus for joining collagen-containing materials |
ES2340142T3 (en) * | 1994-07-08 | 2010-05-31 | Ev3 Inc. | SYSTEM TO CARRY OUT AN INTRAVASCULAR PROCEDURE. |
US5972023A (en) | 1994-08-15 | 1999-10-26 | Eva Corporation | Implantation device for an aortic graft method of treating aortic aneurysm |
US5931165A (en) | 1994-09-06 | 1999-08-03 | Fusion Medical Technologies, Inc. | Films having improved characteristics and methods for their preparation and use |
US5662643A (en) | 1994-09-28 | 1997-09-02 | Abiomed R & D, Inc. | Laser welding system |
US6087552A (en) | 1994-11-15 | 2000-07-11 | Sisters Of Providence Of Oregon | Method of producing fused biomaterials and tissue |
US5665109A (en) | 1994-12-29 | 1997-09-09 | Yoon; Inbae | Methods and apparatus for suturing tissue |
US5713891A (en) | 1995-06-02 | 1998-02-03 | Children's Medical Center Corporation | Modified solder for delivery of bioactive substances and methods of use thereof |
US5895356A (en) * | 1995-11-15 | 1999-04-20 | American Medical Systems, Inc. | Apparatus and method for transurethral focussed ultrasound therapy |
NL1001890C2 (en) | 1995-12-13 | 1997-06-17 | Cordis Europ | Catheter with plate-shaped electrode array. |
JPH09164147A (en) * | 1995-12-15 | 1997-06-24 | Olympus Optical Co Ltd | Ultrasonic medical treatment apparatus |
US6475213B1 (en) * | 1996-01-19 | 2002-11-05 | Ep Technologies, Inc. | Method of ablating body tissue |
US5827265A (en) | 1996-02-07 | 1998-10-27 | Regents Of The University Of California | Intraluminal tissue welding for anastomosis |
US5814065A (en) | 1996-02-09 | 1998-09-29 | Cordis Corporation | Suture delivery tool |
US5676692A (en) * | 1996-03-28 | 1997-10-14 | Indianapolis Center For Advanced Research, Inc. | Focussed ultrasound tissue treatment method |
US5728133A (en) | 1996-07-09 | 1998-03-17 | Cardiologics, L.L.C. | Anchoring device and method for sealing percutaneous punctures in vessels |
US6451044B1 (en) * | 1996-09-20 | 2002-09-17 | Board Of Regents, The University Of Texas System | Method and apparatus for heating inflammed tissue |
US5827268A (en) | 1996-10-30 | 1998-10-27 | Hearten Medical, Inc. | Device for the treatment of patent ductus arteriosus and method of using the device |
US5972024A (en) | 1996-12-24 | 1999-10-26 | Metacardia, Inc. | Suture-staple apparatus and method |
US6083223A (en) | 1997-08-28 | 2000-07-04 | Baker; James A. | Methods and apparatus for welding blood vessels |
US6187003B1 (en) | 1997-11-12 | 2001-02-13 | Sherwood Services Ag | Bipolar electrosurgical instrument for sealing vessels |
DE19801646A1 (en) * | 1998-01-17 | 1999-07-22 | Bayer Ag | New bicyclic lactone glutamate receptor modulators for treating cerebral ischemia, cranial/brain trauma, pain or CNS-mediated spasms |
US5944738A (en) | 1998-02-06 | 1999-08-31 | Aga Medical Corporation | Percutaneous catheter directed constricting occlusion device |
WO1999049788A1 (en) * | 1998-03-30 | 1999-10-07 | Focus Surgery, Inc. | Ablation system |
US6740082B2 (en) * | 1998-12-29 | 2004-05-25 | John H. Shadduck | Surgical instruments for treating gastro-esophageal reflux |
US6086586A (en) | 1998-09-14 | 2000-07-11 | Enable Medical Corporation | Bipolar tissue grasping apparatus and tissue welding method |
US6086570A (en) | 1998-09-29 | 2000-07-11 | A-Med Systems, Inc. | Hemostasis valve with membranes having offset apertures |
WO2000019926A1 (en) * | 1998-10-05 | 2000-04-13 | Scimed Life Systems, Inc. | Large area thermal ablation |
US5919200A (en) | 1998-10-09 | 1999-07-06 | Hearten Medical, Inc. | Balloon catheter for abrading a patent foramen ovale and method of using the balloon catheter |
JP2000201942A (en) * | 1999-01-14 | 2000-07-25 | Toshiba Corp | Ultrasonic therapeutic device |
US6423057B1 (en) * | 1999-01-25 | 2002-07-23 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method and apparatus for monitoring and controlling tissue temperature and lesion formation in radio-frequency ablation procedures |
AU6786200A (en) | 1999-08-20 | 2001-03-19 | Miracle Medical/Surgical Technologies Inc. | Method and system for laser tissue welding |
EP1241994A4 (en) | 1999-12-23 | 2005-12-14 | Therus Corp | Ultrasound transducers for imaging and therapy |
US6451013B1 (en) * | 2000-01-19 | 2002-09-17 | Medtronic Xomed, Inc. | Methods of tonsil reduction using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
US6409720B1 (en) * | 2000-01-19 | 2002-06-25 | Medtronic Xomed, Inc. | Methods of tongue reduction using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
US6413254B1 (en) * | 2000-01-19 | 2002-07-02 | Medtronic Xomed, Inc. | Method of tongue reduction by thermal ablation using high intensity focused ultrasound |
US6595934B1 (en) * | 2000-01-19 | 2003-07-22 | Medtronic Xomed, Inc. | Methods of skin rejuvenation using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions |
US20020032394A1 (en) * | 2000-03-08 | 2002-03-14 | Axel Brisken | Methods, systems, and kits for plaque stabilization |
US6605084B2 (en) * | 2000-03-24 | 2003-08-12 | Transurgical, Inc. | Apparatus and methods for intrabody thermal treatment |
US6946134B1 (en) * | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US6650923B1 (en) * | 2000-04-13 | 2003-11-18 | Ev3 Sunnyvale, Inc. | Method for accessing the left atrium of the heart by locating the fossa ovalis |
US6419648B1 (en) * | 2000-04-21 | 2002-07-16 | Insightec-Txsonics Ltd. | Systems and methods for reducing secondary hot spots in a phased array focused ultrasound system |
WO2001082778A2 (en) * | 2000-04-28 | 2001-11-08 | Focus Surgery, Inc. | Ablation system with visualization |
WO2002005868A2 (en) * | 2000-07-13 | 2002-01-24 | Transurgical, Inc. | Thermal treatment methods and apparatus with focused energy application |
US6618620B1 (en) * | 2000-11-28 | 2003-09-09 | Txsonics Ltd. | Apparatus for controlling thermal dosing in an thermal treatment system |
FR2827149B1 (en) * | 2001-07-13 | 2003-10-10 | Technomed Medical Systems | FOCUSED ULTRASOUND TREATMENT PROBE |
JP2003033365A (en) * | 2001-07-23 | 2003-02-04 | Hitachi Ltd | Ultrasonic wave treatment apparatus |
US20050267495A1 (en) | 2004-05-17 | 2005-12-01 | Gateway Medical, Inc. | Systems and methods for closing internal tissue defects |
US6893431B2 (en) * | 2001-10-15 | 2005-05-17 | Scimed Life Systems, Inc. | Medical device for delivering patches |
US6929644B2 (en) * | 2001-10-22 | 2005-08-16 | Surgrx Inc. | Electrosurgical jaw structure for controlled energy delivery |
US6926716B2 (en) * | 2001-11-09 | 2005-08-09 | Surgrx Inc. | Electrosurgical instrument |
US6770072B1 (en) * | 2001-10-22 | 2004-08-03 | Surgrx, Inc. | Electrosurgical jaw structure for controlled energy delivery |
US7311701B2 (en) * | 2003-06-10 | 2007-12-25 | Cierra, Inc. | Methods and apparatus for non-invasively treating atrial fibrillation using high intensity focused ultrasound |
US20050192627A1 (en) | 2003-10-10 | 2005-09-01 | Whisenant Brian K. | Patent foramen ovale closure devices, delivery apparatus and related methods and systems |
EP1680027A2 (en) * | 2003-10-10 | 2006-07-19 | Proximare, Inc. | Patent foramen ovale (pfo) closure devices, delivery apparatus and related methods and systems |
WO2005046487A1 (en) | 2003-11-06 | 2005-05-26 | Nmt Medical, Inc. | Transseptal puncture apparatus |
EP1713401A2 (en) | 2004-01-30 | 2006-10-25 | NMT Medical, Inc. | Devices, systems, and methods for closure of cardiac openings |
US8262694B2 (en) | 2004-01-30 | 2012-09-11 | W.L. Gore & Associates, Inc. | Devices, systems, and methods for closure of cardiac openings |
US7282051B2 (en) * | 2004-02-04 | 2007-10-16 | Boston Scientific Scimed, Inc. | Ablation probe for delivering fluid through porous structure |
US20050187568A1 (en) | 2004-02-20 | 2005-08-25 | Klenk Alan R. | Devices and methods for closing a patent foramen ovale with a coil-shaped closure device |
-
2004
- 2004-01-23 US US10/764,148 patent/US7311701B2/en not_active Expired - Fee Related
- 2004-06-09 JP JP2006533680A patent/JP4970037B2/en not_active Expired - Fee Related
- 2004-06-09 CN CN2004800192383A patent/CN1816308B/en not_active Expired - Fee Related
- 2004-06-09 EP EP04754905.0A patent/EP1633266B1/en not_active Not-in-force
- 2004-06-09 CN CN2010101567340A patent/CN101874915A/en active Pending
- 2004-06-09 WO PCT/US2004/018452 patent/WO2005000097A2/en active Search and Examination
-
2006
- 2006-07-26 US US11/494,387 patent/US9302125B2/en not_active Expired - Fee Related
-
2007
- 2007-11-05 US US11/934,891 patent/US20080058683A1/en not_active Abandoned
-
2010
- 2010-09-21 JP JP2010211416A patent/JP2011036688A/en not_active Withdrawn
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2275167A (en) * | 1939-04-26 | 1942-03-03 | Bierman William | Electrosurgical instrument |
US2580628A (en) * | 1950-07-12 | 1952-01-01 | Bowen & Company Inc | Suction electrode |
US3490442A (en) * | 1966-02-09 | 1970-01-20 | Hellige & Co Gmbh F | Electrode with contact-forming suction cup means |
US3874388A (en) * | 1973-02-12 | 1975-04-01 | Ochsner Med Found Alton | Shunt defect closure system |
US3862627A (en) * | 1973-08-16 | 1975-01-28 | Sr Wendel J Hans | Suction electrode |
US4326529A (en) * | 1978-05-26 | 1982-04-27 | The United States Of America As Represented By The United States Department Of Energy | Corneal-shaping electrode |
US4562838A (en) * | 1981-01-23 | 1986-01-07 | Walker William S | Electrosurgery instrument |
US5409479A (en) * | 1983-10-06 | 1995-04-25 | Premier Laser Systems, Inc. | Method for closing tissue wounds using radiative energy beams |
US4798594A (en) * | 1987-09-21 | 1989-01-17 | Cordis Corporation | Medical instrument valve |
US4895565A (en) * | 1987-09-21 | 1990-01-23 | Cordis Corporation | Medical instrument valve |
US4832048A (en) * | 1987-10-29 | 1989-05-23 | Cordis Corporation | Suction ablation catheter |
US4919129A (en) * | 1987-11-30 | 1990-04-24 | Celebration Medical Products, Inc. | Extendable electrocautery surgery apparatus and method |
US4929246A (en) * | 1988-10-27 | 1990-05-29 | C. R. Bard, Inc. | Method for closing and sealing an artery after removing a catheter |
US4911159A (en) * | 1988-11-21 | 1990-03-27 | Johnson Jeffrey W | Electrosurgical instrument with electrical contacts between the probe and the probe holder |
US4986889A (en) * | 1988-12-23 | 1991-01-22 | Societe Des Techniques En Milieu Ionisant Stmi | Suction cup for the electrolytic treatment of a surface |
US5078717A (en) * | 1989-04-13 | 1992-01-07 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US5209756A (en) * | 1989-11-03 | 1993-05-11 | Bahaa Botros Seedhom | Ligament fixation staple |
US5099827A (en) * | 1989-12-13 | 1992-03-31 | Richard Wolf Gmbh | Instrument set for closing opened body organs, wounds or the like |
US5725522A (en) * | 1990-06-15 | 1998-03-10 | Rare Earth Medical, Inc. | Laser suturing of biological materials |
US5207670A (en) * | 1990-06-15 | 1993-05-04 | Rare Earth Medical, Inc. | Photoreactive suturing of biological materials |
US5292362A (en) * | 1990-07-27 | 1994-03-08 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
US5611794A (en) * | 1990-10-11 | 1997-03-18 | Lasersurge, Inc. | Clamp for approximating tissue sections |
US5749895A (en) * | 1991-02-13 | 1998-05-12 | Fusion Medical Technologies, Inc. | Method for bonding or fusion of biological tissue and material |
US5195959A (en) * | 1991-05-31 | 1993-03-23 | Paul C. Smith | Electrosurgical device with suction and irrigation |
US5196007A (en) * | 1991-06-07 | 1993-03-23 | Alan Ellman | Electrosurgical handpiece with activator |
US5620481A (en) * | 1991-07-05 | 1997-04-15 | Desai; Jawahar M. | Device for multi-phase radio-frequency ablation |
US5383917A (en) * | 1991-07-05 | 1995-01-24 | Jawahar M. Desai | Device and method for multi-phase radio-frequency ablation |
US5380304A (en) * | 1991-08-07 | 1995-01-10 | Cook Incorporated | Flexible, kink-resistant, introducer sheath and method of manufacture |
US5197963A (en) * | 1991-12-02 | 1993-03-30 | Everest Medical Corporation | Electrosurgical instrument with extendable sheath for irrigation and aspiration |
US5295955A (en) * | 1992-02-14 | 1994-03-22 | Amt, Inc. | Method and apparatus for microwave aided liposuction |
US5507744A (en) * | 1992-04-23 | 1996-04-16 | Scimed Life Systems, Inc. | Apparatus and method for sealing vascular punctures |
US6063085A (en) * | 1992-04-23 | 2000-05-16 | Scimed Life Systems, Inc. | Apparatus and method for sealing vascular punctures |
US5409481A (en) * | 1992-05-21 | 1995-04-25 | Laserscope | Laser tissue welding control system |
US5500012A (en) * | 1992-07-15 | 1996-03-19 | Angeion Corporation | Ablation catheter system |
US5871443A (en) * | 1992-09-25 | 1999-02-16 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
US5290278A (en) * | 1992-10-20 | 1994-03-01 | Proclosure Inc. | Method and apparatus for applying thermal energy to luminal tissue |
US5300065A (en) * | 1992-11-06 | 1994-04-05 | Proclosure Inc. | Method and apparatus for simultaneously holding and sealing tissue |
US6168594B1 (en) * | 1992-11-13 | 2001-01-02 | Scimed Life Systems, Inc. | Electrophysiology RF energy treatment device |
US6036699A (en) * | 1992-12-10 | 2000-03-14 | Perclose, Inc. | Device and method for suturing tissue |
US5405322A (en) * | 1993-08-12 | 1995-04-11 | Boston Scientific Corporation | Method for treating aneurysms with a thermal source |
US5505730A (en) * | 1994-06-24 | 1996-04-09 | Stuart D. Edwards | Thin layer ablation apparatus |
US6682546B2 (en) * | 1994-07-08 | 2004-01-27 | Aga Medical Corporation | Intravascular occlusion devices |
US5730742A (en) * | 1994-08-04 | 1998-03-24 | Alto Development Corporation | Inclined, flared, thermally-insulated, anti-clog tip for electrocautery suction tubes |
US6236875B1 (en) * | 1994-10-07 | 2001-05-22 | Surgical Navigation Technologies | Surgical navigation systems including reference and localization frames |
US6211335B1 (en) * | 1995-01-20 | 2001-04-03 | The Microsearch Foundation Of Australia | Method of tissue repair |
US6716211B2 (en) * | 1995-02-22 | 2004-04-06 | Medtronic, Inc. | Medical device with porous metal element |
US6063081A (en) * | 1995-02-22 | 2000-05-16 | Medtronic, Inc. | Fluid-assisted electrocautery device |
US5626607A (en) * | 1995-04-03 | 1997-05-06 | Heartport, Inc. | Clamp assembly and method of use |
US5709224A (en) * | 1995-06-07 | 1998-01-20 | Radiotherapeutics Corporation | Method and device for permanent vessel occlusion |
US5855312A (en) * | 1996-07-25 | 1999-01-05 | Toledano; Haviv | Flexible annular stapler for closed surgery of hollow organs |
US6056760A (en) * | 1997-01-30 | 2000-05-02 | Nissho Corporation | Device for intracardiac suture |
US6221068B1 (en) * | 1998-01-15 | 2001-04-24 | Northwestern University | Method for welding tissue |
US6562037B2 (en) * | 1998-02-12 | 2003-05-13 | Boris E. Paton | Bonding of soft biological tissues by passing high frequency electric current therethrough |
US6736810B2 (en) * | 1998-07-07 | 2004-05-18 | Medtronic, Inc. | Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue |
US20030028189A1 (en) * | 1998-08-11 | 2003-02-06 | Arthrocare Corporation | Systems and methods for electrosurgical tissue treatment |
US6355030B1 (en) * | 1998-09-25 | 2002-03-12 | Cardiothoracic Systems, Inc. | Instruments and methods employing thermal energy for the repair and replacement of cardiac valves |
US20040098031A1 (en) * | 1998-11-06 | 2004-05-20 | Van Der Burg Erik J. | Method and device for left atrial appendage occlusion |
US6676685B2 (en) * | 1999-02-22 | 2004-01-13 | Tyco Healthcare Group Lp | Arterial hole closure apparatus |
US6712836B1 (en) * | 1999-05-13 | 2004-03-30 | St. Jude Medical Atg, Inc. | Apparatus and methods for closing septal defects and occluding blood flow |
US6375668B1 (en) * | 1999-06-02 | 2002-04-23 | Hanson S. Gifford | Devices and methods for treating vascular malformations |
US20050033327A1 (en) * | 1999-09-07 | 2005-02-10 | John Gainor | Retrievable septal defect closure device |
US6712804B2 (en) * | 1999-09-20 | 2004-03-30 | Ev3 Sunnyvale, Inc. | Method of closing an opening in a wall of the heart |
US7025756B2 (en) * | 1999-09-20 | 2006-04-11 | Ev 3 Sunnyvale, Inc. | Method of securing tissue |
US20030069570A1 (en) * | 1999-10-02 | 2003-04-10 | Witzel Thomas H. | Methods for repairing mitral valve annulus percutaneously |
US6391049B1 (en) * | 1999-10-06 | 2002-05-21 | Board Of Regents The University Of Texas System | Solid biodegradable device for use in tissue repair |
US6730108B2 (en) * | 1999-10-27 | 2004-05-04 | Atritech, Inc. | Barrier device for ostium of left atrial appendage |
US6383198B1 (en) * | 1999-12-07 | 2002-05-07 | Scimed Life System, Inc. | Flexible vacuum grabber for holding lesions |
US20040059347A1 (en) * | 1999-12-07 | 2004-03-25 | Peter Hamilton | Flexible vacuum grabber for holding lesions |
US6726718B1 (en) * | 1999-12-13 | 2004-04-27 | St. Jude Medical, Inc. | Medical articles prepared for cell adhesion |
US6391048B1 (en) * | 2000-01-05 | 2002-05-21 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant and methods of use |
US6692450B1 (en) * | 2000-01-19 | 2004-02-17 | Medtronic Xomed, Inc. | Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same |
US6558314B1 (en) * | 2000-02-11 | 2003-05-06 | Iotek, Inc. | Devices and method for manipulation of organ tissue |
US6514250B1 (en) * | 2000-04-27 | 2003-02-04 | Medtronic, Inc. | Suction stabilized epicardial ablation devices |
US6887238B2 (en) * | 2000-04-27 | 2005-05-03 | Medtronic, Inc. | Suction stabilized epicardial ablation devices |
US6558382B2 (en) * | 2000-04-27 | 2003-05-06 | Medtronic, Inc. | Suction stabilized epicardial ablation devices |
US20050021059A1 (en) * | 2000-04-29 | 2005-01-27 | Cole David H. | Magnetic components for use in forming anastomoses, creating ports in vessels and closing openings in tissue |
US6846319B2 (en) * | 2000-12-14 | 2005-01-25 | Core Medical, Inc. | Devices for sealing openings through tissue and apparatus and methods for delivering them |
US20030092988A1 (en) * | 2001-05-29 | 2003-05-15 | Makin Inder Raj S. | Staging medical treatment using ultrasound |
US20030045893A1 (en) * | 2001-09-06 | 2003-03-06 | Integrated Vascular Systems, Inc. | Clip apparatus for closing septal defects and methods of use |
US20060052821A1 (en) * | 2001-09-06 | 2006-03-09 | Ovalis, Inc. | Systems and methods for treating septal defects |
US20030045901A1 (en) * | 2001-09-06 | 2003-03-06 | Nmt Medical, Inc. | Flexible delivery system |
US20030050665A1 (en) * | 2001-09-07 | 2003-03-13 | Integrated Vascular Systems, Inc. | Needle apparatus for closing septal defects and methods for using such apparatus |
US6702835B2 (en) * | 2001-09-07 | 2004-03-09 | Core Medical, Inc. | Needle apparatus for closing septal defects and methods for using such apparatus |
US20030065364A1 (en) * | 2001-09-28 | 2003-04-03 | Ethicon, Inc. | Expandable intracardiac return electrode and method of use |
US20030078578A1 (en) * | 2001-10-22 | 2003-04-24 | Csaba Truckai | Electrosurgical instrument and method of use |
US20030093071A1 (en) * | 2001-11-15 | 2003-05-15 | Hauck Wallace N. | Cardiac valve leaflet stapler device and methods thereof |
US6733498B2 (en) * | 2002-02-19 | 2004-05-11 | Live Tissue Connect, Inc. | System and method for control of tissue welding |
US20060036284A1 (en) * | 2002-05-06 | 2006-02-16 | Velocimed, Llc | PFO closure devices and related methods of use |
US20040098042A1 (en) * | 2002-06-03 | 2004-05-20 | Devellian Carol A. | Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof |
US20040092973A1 (en) * | 2002-09-23 | 2004-05-13 | Nmt Medical, Inc. | Septal puncture device |
US20040102721A1 (en) * | 2002-11-22 | 2004-05-27 | Mckinley Laurence M. | System, method and apparatus for locating, measuring and evaluating the enlargement of a foramen |
US20050033288A1 (en) * | 2003-02-13 | 2005-02-10 | Coaptus Medical Corporation | Transseptal left atrial access and septal closure |
US7165552B2 (en) * | 2003-03-27 | 2007-01-23 | Cierra, Inc. | Methods and apparatus for treatment of patent foramen ovale |
US20050055050A1 (en) * | 2003-07-24 | 2005-03-10 | Alfaro Arthur A. | Intravascular occlusion device |
US20050065506A1 (en) * | 2003-09-12 | 2005-03-24 | Scimed Life Systems, Inc. | Vacuum-based catheter stabilizer |
US20050075665A1 (en) * | 2003-09-19 | 2005-04-07 | St. Jude Medical, Inc. | Apparatus and methods for tissue gathering and securing |
US20050065509A1 (en) * | 2003-09-22 | 2005-03-24 | Scimed Life Systems, Inc. | Flat electrode arrays for generating flat lesions |
US20050070923A1 (en) * | 2003-09-26 | 2005-03-31 | Mcintosh Scott A. | Device and method for suturing intracardiac defects |
US20060069408A1 (en) * | 2004-09-29 | 2006-03-30 | Terumo Kabushiki Kaisha | Device for treating a patent foramen ovale |
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US20090240146A1 (en) * | 2007-10-26 | 2009-09-24 | Liposonix, Inc. | Mechanical arm |
US9248318B2 (en) | 2008-08-06 | 2016-02-02 | Mirabilis Medica Inc. | Optimization and feedback control of HIFU power deposition through the analysis of detected signal characteristics |
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US8845559B2 (en) | 2008-10-03 | 2014-09-30 | Mirabilis Medica Inc. | Method and apparatus for treating tissues with HIFU |
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Also Published As
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US20070027445A1 (en) | 2007-02-01 |
EP1633266A4 (en) | 2008-12-03 |
US7311701B2 (en) | 2007-12-25 |
CN1816308B (en) | 2010-05-12 |
JP4970037B2 (en) | 2012-07-04 |
CN101874915A (en) | 2010-11-03 |
JP2011036688A (en) | 2011-02-24 |
US20050228283A1 (en) | 2005-10-13 |
EP1633266A2 (en) | 2006-03-15 |
WO2005000097A3 (en) | 2005-05-19 |
CN1816308A (en) | 2006-08-09 |
JP2007503290A (en) | 2007-02-22 |
WO2005000097A2 (en) | 2005-01-06 |
EP1633266B1 (en) | 2016-05-18 |
US9302125B2 (en) | 2016-04-05 |
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