US20080135583A1 - Liquid Dispensing System - Google Patents
Liquid Dispensing System Download PDFInfo
- Publication number
- US20080135583A1 US20080135583A1 US11/795,425 US79542505A US2008135583A1 US 20080135583 A1 US20080135583 A1 US 20080135583A1 US 79542505 A US79542505 A US 79542505A US 2008135583 A1 US2008135583 A1 US 2008135583A1
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- United States
- Prior art keywords
- armature
- dispensing system
- liquid
- liquid dispensing
- cartridge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
- G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0666—Solenoid valves
Definitions
- This invention relates to a liquid dispensing system for dispensing sub-millilitre volumes of liquid. Such small volumes are used in laboratory experiments and tests such as in vitro diagnosis of conditions from samples such as blood serum, urine and the like. This invention could also be applied in the field of drink dispensing.
- In vitro diagnosis requires the use of between two and five reagents (most commonly three) stored in a machine and added successively to a prepared sample.
- the reagents are generally expensive, so that it is advantageous to use as little as possible for each test, particularly in view of the fact that medical staff require an increasing number of tests to be done in order to confirm diagnoses. It is important that the volumes of reagent used are measured accurately, so that the test results are accurate and repeatable.
- the amount of reagent used is in the range of 200 to 1000 microlitres, as it is difficult and expensive to make a diagnostic machine which can dispense lesser volumes from a reservoir sufficiently accurately.
- the liquid is usually dispensed via pipettes or syringes, using systems involving valves and seals, which suffer from hysteresis and so affect accuracy.
- a further problem with dispensing liquids is cross-contamination, which occurs when the reagent touches samples, other reagents or non-sterile surfaces. Drops of liquid tend to be left on the dispenser, and these may be difficult to remove without touching. Obviously, cross-contamination needs to be avoided if the tests are to be accurate and repeatable.
- a further problem with dispensing small volumes of liquid is that, in order to maintain accuracy, it must be ensured that all of the liquid intended to be dispensed is actually expelled from the dispensing device.
- the aim of the invention is to increase the accuracy of dispensing small volumes of liquid (from 2 to 80 microlitres) from a machine, while avoiding cross-contamination, and providing ease of replenishment of the liquids in the machine, such as by the use of disposable cartridges.
- a liquid dispensing system comprising a cartridge in which liquid to be dispensed is retained and at least one solenoid assembly, the solenoid assembly comprising a coil and an armature, the armature being movably mounted within the cartridge and the coil being separate from the cartridge, movement of the armature acting to expel liquid from the cartridge.
- the coil can be made part of the dispensing apparatus and the cartridge, which contains the armature, can be mounted within the coil.
- the cartridge can be replaced.
- the cartridge is disposable. This reduces the chance of contamination and the cartridge can be constructed in a factory to dispense accurate and consistent volumes of liquid, such as a reagent. The use of the armature movement to actively expel the liquid assists in accurate dispensing.
- the cartridge when assembled, comprises the cartridge body, the armature, a return spring for the armature, and a nozzle assembly.
- the liquid is expelled through the nozzle assembly.
- the armature is biased by the return spring towards a first position, and towards a second position by activation of the coil.
- the armature is moved in one direction by activation of the coil, and in the opposite direction by the return spring.
- the armature conveniently moves axially within the cartridge.
- the arrangement may be such that in the first position the armature closes off flow through the nozzle assembly.
- the normal position of the armature that is, with the coil inactive or when the cartridge is not installed in the dispensing system
- This has the advantage that liquid will not escape in the normal position, so that the cartridge can be filled with liquid, sealed and delivered to the point of use without fear of loss of liquid.
- the nozzle assembly is closed off, when the cartridge is installed in the dispensing system, but no liquid is being dispensed.
- the spring is normally separate from the cartridge, armature and nozzle assembly.
- the arrangement may be such that in the first position the armature allows flow through the nozzle assembly. Activation of the coil then moves the armature to dispense the liquid, while the return spring simply returns the armature to the first position.
- the return spring may be integrally formed with the nozzle assembly. This is advantageous from a manufacturing point of view, as it reduces the number of components.
- the armature comprises iron or other magnetic material.
- the armature can be constructed relatively inexpensively and is thus disposable as the solenoid coil is separate from it.
- the armature slides within the cartridge.
- the cartridge may be disposed within the coil when the cartridge is mounted in the dispensing system.
- the cartridge has two chambers, of which the first chamber is a reservoir for the liquid and the second chamber retains the armature.
- the second chamber is disposed within the coil when the cartridge is mounted in the dispensing system.
- the armature may define a dispensing chamber in the second chamber in which the liquid to be dispensed collects. This is advantageous as a measured quantity of liquid can be transferred to the dispensing chamber from the reservoir before dispensing.
- the armature has a fluid flow path for transferring fluid from the reservoir to the dispensing chamber.
- the fluid flow path may comprise a bore through the armature. Alternatively it may comprise an annular groove in its outer surface.
- axial movement of the armature in one direction dispenses the liquid and in the other direction, pumps liquid from the reservoir into the dispensing chamber.
- the nozzle assembly may also include a one-way valve, such as a “duck-bill” valve. This is advantageous, especially where liquid is dispensed by movement of the armature due to activation of the coil, as no air is also drawn into the dispensing chamber when the armature pumps liquid from the reservoir.
- a one-way valve such as a “duck-bill” valve.
- the dispensing system includes one solenoid coil.
- it may comprise two solenoid coils.
- the cartridge may contain two armatures and two dispensing chambers.
- the reservoir may have a pressure/vacuum source attached thereto.
- the pressure/vacuum source can be used to control more carefully the amount of fluid dispensed, and, if a vacuum is applied to the reservoir, the hydrostatic pressure of a large head of liquid in the reservoir can be supported.
- the cartridge includes a lid having a moulded hinge. This allows the liquid in the reservoir to be agitated or refilled as necessary.
- the nozzle assembly is mounted with the cartridge by interference fit or with adhesive or it may be integrally moulded therewith.
- the nozzle assembly has a nozzle and a shroud to protect the nozzle from damage or contamination.
- the nozzle or dispensing chamber may have a hydrophobic coating to aid complete expulsion of liquid therefrom. Preferably, they both have a hydrophobic coating.
- liquid dispensing system of the invention is adapted to dispense microlitres of liquid.
- FIG. 1 shows an exploded view of the cartridge and solenoid coil according to the invention
- FIG. 2 shows a modification to the nozzle assembly shown in FIG. 1 ;
- FIGS. 3 a and 3 b show a first embodiment of the invention
- FIG. 4 shows a modification to the nozzle of the dispensing system shown in FIGS. 3 a and 3 b;
- FIG. 5 shows a second embodiment of the invention
- FIGS. 6 a , 6 b and 6 c show a third embodiment of the invention.
- FIGS. 7 a , 7 b and 7 c show a fourth embodiment of the invention.
- FIGS. 8 a , 8 b and 8 c show a fifth embodiment of the invention that incorporates a collar section on the armature
- FIG. 9 is a perspective view of the armature and the collar section of the fifth embodiment.
- FIGS. 10 a , 10 b and 10 c show a sixth embodiment of the invention that incorporates two solenoid assemblies.
- the liquid dispensing system 1 of FIG. 1 comprises a cartridge 2 , an armature 3 and a nozzle assembly 4 .
- the cartridge 2 comprises a hollow body 5 , which is divided into a first chamber 6 and a second chamber 7 by a valve seat 8 .
- the first chamber 6 forms a reservoir which, in use, retains liquid to be dispensed by the system.
- the second chamber 7 defines an axial armature bore within which the armature 3 can move.
- the nozzle assembly 4 retains the armature 3 in the bore 7 .
- the liquid dispensing system 1 also includes a solenoid coil 15 of conventional construction having a bore 16 therethrough. Thus, the solenoid coil 15 and the armature 3 together form a solenoid assembly.
- the second chamber 7 of the cartridge 2 is, in use, adapted to be mounted within the bore 16 , thereby enabling the magnetic field generated by the coil 15 to move the armature 3 . Movement of the armature 3 causes liquid from the reservoir 6 to be expelled through the nozzle assembly 4 .
- the nozzle assembly 4 comprises a body 11 of a diameter to closely fit within the bore 7 , an elongate nozzle 12 , a shroud 13 and an integrally formed spring member 14 .
- the elongate nozzle 12 comprises a tapering cylindrical member extending from the body 11 , which has a dispensing bore 17 therethrough. The dispensing bore 17 also extends through the nozzle assembly body 11 .
- the spring member 14 is helical and is moulded integrally with the body 11 . When the nozzle assembly 4 is mounted within bore 16 , the spring member 14 abuts a shoulder 18 on the armature 3 to bias the armature 3 into a first position in which it is adjacent the reservoir 6 .
- the shroud 13 is annular and extends from the body 11 concentrically with the nozzle 12 .
- the annular shroud 13 also extends radially outwards adjacent its junction with the body 11 to define a shoulder 19 .
- the shoulder 19 is adapted to abut the free end of the second chamber 7 to ensure that the nozzle assembly 4 is appropriately mounted therein.
- the shroud 13 protects the nozzle 12 from damage.
- the nozzle 12 may comprise or be coated with a hydrophobic material to aid the expulsion of liquid therefrom.
- FIG. 2 A modification to the nozzle assembly 4 is shown in FIG. 2 in which the shroud 13 comprises two arcuate sections 20 , 20 ′ defining two diametrically opposed slots 21 , 21 ′. This allows the shroud 13 to provide protection for the nozzle 12 and is also easier and cheaper to manufacture, as the nozzle assembly can be moulded across the slots 21 , 21 ′.
- FIG. 2 also shows a modification to the spring member 14 .
- the spring member 14 comprises two spring sections 22 , 22 ′.
- the spring sections 22 , 22 ′ first extend in a longitudinal direction from diametrically opposed edges of body 11 and then extend circumferentially.
- the inwardly facing sides 23 of the spring sections 22 , 22 ′ are arcuate and define a gap to receive the armature 3 , with the spring sections 22 , 22 ′ in abutment with the armature shoulder 18 .
- this modification to the spring member 14 results in less linear travel but is easier and cheaper to manufacture.
- the cartridge 2 has a hinged lid 24 that provides access to the reservoir 6 .
- the lid 24 allows the reservoir 6 of the cartridge 2 to be filled with liquid, such as a reagent for diagnostic testing, and for the liquid to be agitated as necessary.
- the cartridge 2 also has clips 25 projecting from the body 5 which allow the cartridge 2 to be mounted within dispensing apparatus (not shown), or the like, so that the cartridge 2 can be appropriately positioned with the coil 15 .
- the cartridge 2 may be of plastics and formed integrally with the hinged lid 24 by injection moulding or any other appropriate method. It will be appreciated that the material used for the cartridge will depend upon the liquid that is to be dispensed, to ensure that the cartridge material does not react or degrade in the presence of the liquid.
- the nozzle assembly 4 may also be formed by injection moulding.
- the armature 3 or a proportion thereof may be of iron or other magnetic material. Further, the armature 3 may be coated to ensure it does not react or degrade in the presence of the liquid.
- the cartridge 2 , armature 3 and nozzle assembly 3 are simple and inexpensive to manufacture and thus can be disposable.
- FIGS. 3 a and 3 b show, in section, a first embodiment of the liquid dispensing system 1 assembled and mounted in the bore 16 of the solenoid coil 15 .
- the armature 3 has a fluid flow path 26 that extends axially part way through the armature and then radially.
- aperture 27 formed in the base of the armature 3 , adjacent the nozzle assembly 4 , is connected via the flow path 26 to aperture 28 formed in a circumferential side of the armature 3 , adjacent the reservoir 6 .
- the armature ledge 18 is located around the periphery of aperture 27 and thus the spring member 14 has a smaller diameter.
- the reservoir 6 has a port 30 formed in its side wall for applying pressure or a vacuum to the reservoir 6 .
- the solenoid coil 15 has terminals 10 for connecting it to a control system of the dispensing apparatus (not shown).
- the reservoir 6 is filled with liquid 31 and is sealed by the lid 24 .
- the coil 15 is not activated and thus the spring member 14 urges the armature 3 into the first position.
- the nozzle assembly 4 and the armature 3 define therebetween a dispensing chamber 32 in the second chamber 7 .
- the armature 3 is adapted such that it projects into the reservoir 6 such that aperture 28 is open to the liquid 31 .
- the liquid 31 from the reservoir enters aperture 28 , travels through the fluid flow path 26 and out of aperture 27 , and collects in the dispensing chamber 32 .
- the liquid is prevented from draining from the nozzle 12 due to the surface tension formed at the free end of the dispensing bore 17 .
- the form, and in particular the diameter, of the nozzle 12 is chosen to ensure that the particular liquid 31 being dispensed is able to exhibit sufficient surface tension to be retained in the dispensing chamber 32 .
- the pressure port 30 may apply a vacuum to the reservoir 6 to allow a larger “head” of liquid in the reservoir 6 to be supported by the surface tension at the dispensing nozzle 12 .
- the exact location of the armature 3 in the first position and the diameter of the dispensing chamber 32 is chosen so that a precise measured volume of liquid collects in the dispensing chamber 32 , to ensure accurate and repeatable dispensing.
- FIG. 3 b electrical power has been applied to the coil 15 by the dispensing apparatus resulting in a magnetic field, which has drawn the armature 3 into a second position in which it abuts the nozzle assembly 4 .
- the aperture 28 is closed off from the reservoir 6 by the wall of the second chamber 7 .
- the volume of the dispensing chamber 32 is reduced which forces a measured quantity of liquid from the dispensing chamber 32 out of the dispensing bore 17 .
- movement of the armature from the first position to the second position is an active dispensing stroke in which liquid is actively expelled thereby improving accuracy.
- the electrical power to the solenoid coil 15 is removed and the armature 3 will be urged to return to the first position by the spring member 14 .
- the volume of the dispensing chamber 32 increases, which leads to a decrease in pressure within chamber 32 .
- This decrease in pressure effectively pumps liquid 31 from the reservoir 6 into the dispensing chamber 32 , once the aperture 28 is open to the reservoir 6 .
- movement of the armature 3 from the second position to the first position is a pumping stroke.
- air will also be drawn in through the dispensing bore 17 and therefore the system will still rely on gravity to an extent to ensure the dispensing chamber 32 is completely filled.
- the pressure/vacuum port 30 is omitted.
- the dispensing bore 17 is elongated with a length of capillary tubing, and the spring 14 is constructed so that the force acting on the armature returns it relatively slowly to the first position.
- the return force needs to be chosen so that the velocity of the armature creates sufficient force to draw in liquid from the reservoir 6 to the dispensing chamber 32 , but not enough to overcome the surface tension at the capillary end of the bore 17 , so that air is not drawn in.
- the spring force can be altered for different liquids according to their viscosity to achieve this result. Activation of the coil, however, will cause a more rapid movement of the armature, so that the pressure created in the dispensing chamber 32 is sufficient to overcome the surface tension and dispense the liquid.
- FIG. 4 shows a modification to the nozzle assembly 4 of the embodiment shown in FIGS. 3 a and 3 b , which also addresses this problem.
- the pressure/vacuum port 30 is absent and the nozzle 12 incorporates a one-way “duck-bill” style valve 33 .
- the valve 33 only permits flow out of the dispensing bore 17 .
- the dispensing system 1 does not rely on surface tension to retain a measured volume in the dispensing chamber 32 . This obviates the need for the pressure/vacuum port 30 .
- valve 33 prevents air entering the dispensing chamber 32 through the dispensing bore 17 and therefore the reduction in pressure in the dispensing chamber 32 will solely cause liquid 31 from the reservoir 6 to be drawn into chamber 32 . This improves the accuracy and the repeatability of the dispensing device.
- the nozzle 12 is open, so that it may be possible for liquid to leak out.
- the armature 3 and spring 14 are arranged so that the spring force biases the armature 3 to the position where it closes off the dispensing bore 17 , and activation of the coil 15 moves the armature 3 away from the bore 17 .
- the spring 14 is then provided on the opposite end of the armature 3 , as a separate component.
- activation of the coil 15 moves the armature 3 away from the bore 17 to allow liquid to flow into the dispensing chamber 32 from the reservoir 6 .
- the armature 3 returns under the force of the spring 14 to dispense the liquid.
- FIG. 5 shows a second embodiment of the invention having a modified armature 3 .
- the remainder of the liquid dispensing system 1 is the same as the first embodiment and corresponding reference numerals have been applied to corresponding parts.
- the armature 3 of FIG. 5 does not have a machined fluid flow path 26 through the body of the armature 3 . Instead, it is of a lesser diameter than the second chamber 7 such that a flow path is formed between the armature 3 and the walls of the second chamber 7 . As the armature 3 is not machined, this makes it simpler and cheaper to manufacture.
- the liquid dispensing system 1 of this embodiment operates in a similar manner to the previous embodiment in that liquid 31 collects in the dispensing chamber 32 when the armature 3 is in the first position. Similarly, the surface tension of the liquid 31 at the free end of the dispensing bore 17 retains the liquid 31 in the chamber 32 .
- the solenoid coil 15 Upon activation of the solenoid coil 15 , the armature 3 is driven into the second position by the magnetic force, against the force of the spring member 14 . This dispensing stroke forces the fluid 31 in the dispensing chamber 32 out of the nozzle 12 . It will be appreciated that a certain amount of liquid will also be forced back into the reservoir 6 through flow path 26 .
- the area of the flow path 26 and the size of the dispensing chamber 32 when the armature 3 is in the first position can be chosen so that a precise and repeatable quantity of liquid is expelled from the nozzle 12 during each dispensing stroke.
- both liquid from the reservoir 6 and atmospheric air through the dispensing bore 17 will be drawn into the dispensing chamber 32 .
- the chamber 32 is then completely filled with liquid 31 by it flowing under gravity from the reservoir 6 , through the fluid flow path 26 .
- FIGS. 6 a , 6 b and 6 c show a third embodiment that includes a modified armature 3 and second chamber 7 .
- the armature 3 comprises a cylindrical body having a circumferential groove 34 therein, such that when the armature 3 is in the first position (see FIG. 6 a ), the groove 34 is open to the reservoir 6 .
- the second chamber 7 also has a groove in its inner wall that forms an intermediate chamber 35 .
- the intermediate chamber 35 is positioned such that when the armature 3 is in the second position the groove 34 aligns with the chamber 35 . In the second position, liquid 31 is prevented from flowing freely from the reservoir 6 to the intermediate chamber 35 by a radial flange 36 of the armature 3 .
- liquid 31 from the reservoir 6 collects within the groove 34 when the armature 3 is in the first position.
- Activation of the solenoid coil 15 draws the armature 3 downwards into the second position against the force of the spring member 14 .
- the liquid that has collected with the groove 34 is drawn downwards with the armature 3 .
- the groove 34 is aligned with the intermediate chamber 35 .
- the liquid in the groove 34 flows freely into the intermediate chamber 35 (as shown in FIG. 6 b ).
- the pumping stroke in which liquid 31 is urged from the reservoir 6 , occurs when the armature moves from the first position to the second position.
- the armature When the solenoid coil 15 is deactivated, the armature returns to the first position under the force of spring member 14 . The liquid 31 transferred to the intermediate chamber 35 is then able to flow from the chamber 35 into the dispensing chamber 32 . As shown in FIG. 6 c , the majority of the liquid collects in the dispensing bore 17 and the majority of the dispensing chamber 32 is filled with air. The liquid is held in the dispensing bore 17 by surface tension. The liquid is dispensed when the solenoid coil 15 is activated once again and the armature 3 moves to the second position. The resulting pressure from reduction in volume of the dispensing chamber 32 overcomes the surface tension and forces the liquid from the dispensing bore 17 .
- the air in the dispensing chamber 32 is also forced out of the bore 17 , which helps to ensure that all of the liquid is actively expelled from the dispensing chamber 32 and bore 17 .
- movement of the armature 3 from the first position to the second position is also an active dispensing stroke.
- the first dispense from this embodiment requires two cycles of the armature 3 (i.e. the solenoid coil 15 is activated and deactivated twice), it will be appreciated that liquid is dispensed on every cycle thereafter.
- FIGS. 7 a , 7 b and 7 c A fourth embodiment of the invention is shown in FIGS. 7 a , 7 b and 7 c , in which there are modifications to the armature 3 , the second chamber 7 and nozzle assembly 4 .
- the armature 3 comprises a body 37 of smaller diameter than the second chamber 7 and has an annular peripheral flange 38 that extends radially outward to a diameter that approaches the internal diameter of the second chamber 7 .
- the armature 3 also carries seals 40 , 41 in its top and bottom faces respectively.
- the second chamber 7 includes an annular elastomeric inlet seal 42 mounted within the second chamber 7 , adjacent the junction with the reservoir 6 .
- the inlet seal 42 prevents flow between itself and the wall of the second chamber 7 and has an aperture 43 .
- the seal 42 is comparable to the valve seat 8 shown in FIG. 1 .
- the nozzle assembly 4 also has an annular elastomeric outlet seal 44 in the nozzle body 11 , which surrounds the proximal end of the dispensing bore 17 .
- the spring member 14 has been omitted from these Figures for clarity, but would extend from the nozzle assembly body 11 and abut flange 38 of the armature 3 .
- FIG. 7 a the armature 3 is shown in the first position, wherein the dispensing chamber 32 is sealed from the reservoir 6 by seal 40 on the armature 3 abutting the inlet seal 42 .
- the armature 3 moves to the second position.
- the seal 40 moves away from the inlet seal 40 and into sealing contact with the outlet seal 44 on the nozzle assembly 4 .
- This movement of the armature 3 acts as a pumping stroke, drawing liquid 31 from the reservoir 6 , past the flange 38 into the dispensing chamber 32 (as shown in FIG. 7 b ).
- Deactivation of the solenoid coil 15 causes the armature 3 to return to the first position under the force of the spring member (not shown).
- seals 41 and 44 are separated, which allows a proportion of the liquid in the dispensing chamber 32 to flow into the dispensing bore 17 .
- the liquid 31 is retained in the dispensing bore 17 by surface tension (see FIG. 7 c ).
- the solenoid coil 15 is activated again and thus the armature 3 moves to the second position, a proportion of the liquid in the dispensing chamber is expelled from the nozzle 12 .
- liquid is dispensed and pumped from the reservoir 6 on the same stroke of the armature 3 from the first to the second position.
- FIGS. 8 a , 8 b and 8 c A fifth embodiment is shown in FIGS. 8 a , 8 b and 8 c .
- the nozzle assembly 4 comprises an elongate nozzle 12 that first extends radially from an aperture 48 in the second chamber 7 and then axially, adjacent the coil 15 (when the second chamber 7 is mounted within the solenoid coil aperture 16 ).
- the second chamber 7 includes an extension portion 45 that extends into the reservoir 6 and has an open end 47 and an inlet aperture 46 in its side wall.
- the second chamber 7 also includes a hollow guide member 50 having a cylindrical open bore 51 .
- the armature 3 comprises a head portion 52 having a support section 53 and a guide section 54 , separated by a shoulder 55 , depending axially therefrom.
- the guide section 54 is received in the bore 51 of the guide member 50 and can axially slide therein.
- An annular slider member 56 is slidably mounted on the support section 53 of armature 3 . Thus, the slider member 56 can slide between the head portion 52 and shoulder 55 .
- the slider member 56 has a series of circumferentially spaced axial channels 57 (see FIG. 9 ) that allows liquid to flow through the member 56 .
- FIG. 8 a shows the armature 3 biased into the first position by the spring member (not shown) in which the head 52 extends into the extension portion 45 , adjacent the reservoir 6 .
- the slider member 56 abuts the shoulder 55 and as such, seals the inlet aperture 46 .
- Liquid 31 from previous cycles is shown in the dispensing chamber 32 and the dispensing bore 17 .
- the armature 3 Upon activation of the coil 15 the armature 3 is drawn into the second position where, in this embodiment, the slider member 56 abuts the guide member 50 .
- This downward movement of the armature 3 is the active dispensing stroke, which reduces the volume of the dispensing chamber 32 and therefore causes liquid 31 to be expelled from the dispensing chamber 32 and bore 17 .
- FIGS. 10 a , 10 b and 10 c A sixth embodiment is shown in FIGS. 10 a , 10 b and 10 c .
- the construction of the liquid dispensing system 1 in this embodiment is similar to the first embodiment except that the cartridge 2 includes third section 59 which extends within an aperture of a second coil 58 and has a second nozzle 60 and second armature 61 mounted within.
- the second coil has terminals 62 for connecting it to the control system of the dispensing apparatus (not shown).
- the second armature 61 has a bore therethrough in which is mounted a one-way valve 63 .
- the third section 59 defines a second dispensing chamber 64 having a second dispensing bore 65 .
- Operation of the first armature 3 is the same as described for the first embodiment, except that downward movement of the armature 3 performs a dosing stroke, in which a measured amount of liquid is transferred through the one-way valve 63 of the second armature 61 , into the second dispensing chamber 64 (as shown in FIG. 10 b ). Then, the second coil 58 can be activated to move the second armature 61 through an active dispensing stroke from a first position in which it is adjacent the nozzle 4 , downward to a second position where it abuts the second nozzle 60 . During the active dispensing stroke, the liquid in the second dispensing chamber 64 is expelled from the second dispensing bore 65 (as shown in FIG. 10 c ).
- the solenoid coils 15 and 58 can then be deactivated so that the first armature 3 returns to the first position under the force of spring member 14 and the second armature returns to its first position under the force of a return spring (not shown).
- a measured quantity of liquid 31 is transferred between dispensing chambers 32 , 64 it is isolated from the effect of the hydrostatic pressure in the reservoir 6 . This is advantageous as the volume of liquid to be dispensed is unaffected by the change in hydrostatic pressure as the quantity of fluid in the reservoir decreases.
- the pressure/vacuum source may be incorporated in any of the embodiments shown or equally omitted, depending upon the application of the liquid dispensing system and the type of liquid being dispensed.
- the pressure/vacuum source can be used to allow greater control of the amount of liquid being dispensed.
- a vacuum can be applied to reduce the pressure in the reservoir 6 , thereby impeding the flow of liquid from the reservoir 6 .
- pressure could be applied to urge liquid from the reservoir 6 , to promote rapid and complete filling of the dispense chamber 32 , for example.
- the “duck-bill” valve 33 or any other suitable one-way valve may also be included in any of the embodiments.
- the armature or nozzle assembly may be coated in or comprise a material suitable for use with the liquid being dispensed which, in particular, may be a hydrophobic material to promote full expulsion from the dispensing chamber 32 and bore 17 on the active dispensing stroke.
- the spring member 14 may be omitted and the armature 3 may be returned to its first position by a reversal of the magnetic field generated by coil 15 .
Abstract
A liquid dispensing system comprises a cartridge (2) in which liquid to be dispensed is retained and at least one solenoid assembly. The solenoid assembly comprises a coil (15) and an armature (3), the armature (3) being movably mounted within the cartridge (2) and the coil (15) being separate from the cartridge (2). Movement of the armature (3) acts to expel liquid from the cartridge (2).
Description
- This invention relates to a liquid dispensing system for dispensing sub-millilitre volumes of liquid. Such small volumes are used in laboratory experiments and tests such as in vitro diagnosis of conditions from samples such as blood serum, urine and the like. This invention could also be applied in the field of drink dispensing.
- In vitro diagnosis requires the use of between two and five reagents (most commonly three) stored in a machine and added successively to a prepared sample. The reagents are generally expensive, so that it is advantageous to use as little as possible for each test, particularly in view of the fact that medical staff require an increasing number of tests to be done in order to confirm diagnoses. It is important that the volumes of reagent used are measured accurately, so that the test results are accurate and repeatable. Currently, the amount of reagent used is in the range of 200 to 1000 microlitres, as it is difficult and expensive to make a diagnostic machine which can dispense lesser volumes from a reservoir sufficiently accurately. The liquid is usually dispensed via pipettes or syringes, using systems involving valves and seals, which suffer from hysteresis and so affect accuracy.
- A further problem with dispensing liquids is cross-contamination, which occurs when the reagent touches samples, other reagents or non-sterile surfaces. Drops of liquid tend to be left on the dispenser, and these may be difficult to remove without touching. Obviously, cross-contamination needs to be avoided if the tests are to be accurate and repeatable.
- A further problem with dispensing small volumes of liquid is that, in order to maintain accuracy, it must be ensured that all of the liquid intended to be dispensed is actually expelled from the dispensing device.
- The aim of the invention is to increase the accuracy of dispensing small volumes of liquid (from 2 to 80 microlitres) from a machine, while avoiding cross-contamination, and providing ease of replenishment of the liquids in the machine, such as by the use of disposable cartridges.
- According to a first aspect of the invention, we provide a liquid dispensing system comprising a cartridge in which liquid to be dispensed is retained and at least one solenoid assembly, the solenoid assembly comprising a coil and an armature, the armature being movably mounted within the cartridge and the coil being separate from the cartridge, movement of the armature acting to expel liquid from the cartridge.
- This is advantageous as the coil can be made part of the dispensing apparatus and the cartridge, which contains the armature, can be mounted within the coil. Once the liquid has all been dispensed by movement of the armature, the cartridge can be replaced. Thus, preferably the cartridge is disposable. This reduces the chance of contamination and the cartridge can be constructed in a factory to dispense accurate and consistent volumes of liquid, such as a reagent. The use of the armature movement to actively expel the liquid assists in accurate dispensing.
- Preferably the cartridge, when assembled, comprises the cartridge body, the armature, a return spring for the armature, and a nozzle assembly. The liquid is expelled through the nozzle assembly.
- The armature is biased by the return spring towards a first position, and towards a second position by activation of the coil. Thus, the armature is moved in one direction by activation of the coil, and in the opposite direction by the return spring. The armature conveniently moves axially within the cartridge.
- The arrangement may be such that in the first position the armature closes off flow through the nozzle assembly. This means that the normal position of the armature (that is, with the coil inactive or when the cartridge is not installed in the dispensing system) is to prevent flow from the cartridge. This has the advantage that liquid will not escape in the normal position, so that the cartridge can be filled with liquid, sealed and delivered to the point of use without fear of loss of liquid. It also means that the nozzle assembly is closed off, when the cartridge is installed in the dispensing system, but no liquid is being dispensed.
- Activation of the coil then moves the armature to allow flow through the nozzle assembly, and movement of the armature in response to the return spring actually dispenses the liquid.
- With this arrangement, the spring is normally separate from the cartridge, armature and nozzle assembly.
- Alternatively, the arrangement may be such that in the first position the armature allows flow through the nozzle assembly. Activation of the coil then moves the armature to dispense the liquid, while the return spring simply returns the armature to the first position.
- With this arrangement the return spring may be integrally formed with the nozzle assembly. This is advantageous from a manufacturing point of view, as it reduces the number of components.
- Preferably the armature comprises iron or other magnetic material. The armature can be constructed relatively inexpensively and is thus disposable as the solenoid coil is separate from it. Preferably, the armature slides within the cartridge.
- The cartridge may be disposed within the coil when the cartridge is mounted in the dispensing system.
- Preferably the cartridge has two chambers, of which the first chamber is a reservoir for the liquid and the second chamber retains the armature. Thus, preferably the second chamber is disposed within the coil when the cartridge is mounted in the dispensing system.
- The armature may define a dispensing chamber in the second chamber in which the liquid to be dispensed collects. This is advantageous as a measured quantity of liquid can be transferred to the dispensing chamber from the reservoir before dispensing.
- Preferably the armature has a fluid flow path for transferring fluid from the reservoir to the dispensing chamber. The fluid flow path may comprise a bore through the armature. Alternatively it may comprise an annular groove in its outer surface.
- Preferably axial movement of the armature in one direction dispenses the liquid and in the other direction, pumps liquid from the reservoir into the dispensing chamber.
- The nozzle assembly may also include a one-way valve, such as a “duck-bill” valve. This is advantageous, especially where liquid is dispensed by movement of the armature due to activation of the coil, as no air is also drawn into the dispensing chamber when the armature pumps liquid from the reservoir.
- Preferably the dispensing system includes one solenoid coil. However alternatively it may comprise two solenoid coils. Thus, the cartridge may contain two armatures and two dispensing chambers.
- The reservoir may have a pressure/vacuum source attached thereto. The pressure/vacuum source can be used to control more carefully the amount of fluid dispensed, and, if a vacuum is applied to the reservoir, the hydrostatic pressure of a large head of liquid in the reservoir can be supported.
- Preferably the cartridge includes a lid having a moulded hinge. This allows the liquid in the reservoir to be agitated or refilled as necessary.
- Preferably the nozzle assembly is mounted with the cartridge by interference fit or with adhesive or it may be integrally moulded therewith.
- Preferably the nozzle assembly has a nozzle and a shroud to protect the nozzle from damage or contamination. Further the nozzle or dispensing chamber may have a hydrophobic coating to aid complete expulsion of liquid therefrom. Preferably, they both have a hydrophobic coating.
- Preferably the liquid dispensing system of the invention is adapted to dispense microlitres of liquid.
- There now follows by way of example only a detailed description of the present invention with reference to the accompanying drawings in which;
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FIG. 1 shows an exploded view of the cartridge and solenoid coil according to the invention; -
FIG. 2 shows a modification to the nozzle assembly shown inFIG. 1 ; -
FIGS. 3 a and 3 b show a first embodiment of the invention; -
FIG. 4 shows a modification to the nozzle of the dispensing system shown inFIGS. 3 a and 3 b; -
FIG. 5 shows a second embodiment of the invention; -
FIGS. 6 a, 6 b and 6 c show a third embodiment of the invention; -
FIGS. 7 a, 7 b and 7 c show a fourth embodiment of the invention; -
FIGS. 8 a, 8 b and 8 c show a fifth embodiment of the invention that incorporates a collar section on the armature; -
FIG. 9 is a perspective view of the armature and the collar section of the fifth embodiment; and -
FIGS. 10 a, 10 b and 10 c show a sixth embodiment of the invention that incorporates two solenoid assemblies. - The
liquid dispensing system 1 ofFIG. 1 comprises acartridge 2, anarmature 3 and anozzle assembly 4. Thecartridge 2 comprises ahollow body 5, which is divided into afirst chamber 6 and asecond chamber 7 by a valve seat 8. Thefirst chamber 6 forms a reservoir which, in use, retains liquid to be dispensed by the system. Thesecond chamber 7 defines an axial armature bore within which thearmature 3 can move. Thenozzle assembly 4 retains thearmature 3 in thebore 7. Theliquid dispensing system 1 also includes asolenoid coil 15 of conventional construction having abore 16 therethrough. Thus, thesolenoid coil 15 and thearmature 3 together form a solenoid assembly. Thesecond chamber 7 of thecartridge 2 is, in use, adapted to be mounted within thebore 16, thereby enabling the magnetic field generated by thecoil 15 to move thearmature 3. Movement of thearmature 3 causes liquid from thereservoir 6 to be expelled through thenozzle assembly 4. - The
nozzle assembly 4 comprises abody 11 of a diameter to closely fit within thebore 7, anelongate nozzle 12, ashroud 13 and an integrally formedspring member 14. Theelongate nozzle 12 comprises a tapering cylindrical member extending from thebody 11, which has a dispensing bore 17 therethrough. The dispensing bore 17 also extends through thenozzle assembly body 11. Thespring member 14 is helical and is moulded integrally with thebody 11. When thenozzle assembly 4 is mounted withinbore 16, thespring member 14 abuts ashoulder 18 on thearmature 3 to bias thearmature 3 into a first position in which it is adjacent thereservoir 6. Theshroud 13 is annular and extends from thebody 11 concentrically with thenozzle 12. Theannular shroud 13 also extends radially outwards adjacent its junction with thebody 11 to define ashoulder 19. Theshoulder 19 is adapted to abut the free end of thesecond chamber 7 to ensure that thenozzle assembly 4 is appropriately mounted therein. Theshroud 13 protects thenozzle 12 from damage. Further, thenozzle 12 may comprise or be coated with a hydrophobic material to aid the expulsion of liquid therefrom. - A modification to the
nozzle assembly 4 is shown inFIG. 2 in which theshroud 13 comprises twoarcuate sections opposed slots shroud 13 to provide protection for thenozzle 12 and is also easier and cheaper to manufacture, as the nozzle assembly can be moulded across theslots FIG. 2 also shows a modification to thespring member 14. In this modification thespring member 14 comprises twospring sections spring sections body 11 and then extend circumferentially. The inwardly facingsides 23 of thespring sections armature 3, with thespring sections armature shoulder 18. As can be appreciated, this modification to thespring member 14 results in less linear travel but is easier and cheaper to manufacture. - The
cartridge 2 has a hingedlid 24 that provides access to thereservoir 6. Thelid 24 allows thereservoir 6 of thecartridge 2 to be filled with liquid, such as a reagent for diagnostic testing, and for the liquid to be agitated as necessary. Thecartridge 2 also hasclips 25 projecting from thebody 5 which allow thecartridge 2 to be mounted within dispensing apparatus (not shown), or the like, so that thecartridge 2 can be appropriately positioned with thecoil 15. - The
cartridge 2 may be of plastics and formed integrally with the hingedlid 24 by injection moulding or any other appropriate method. It will be appreciated that the material used for the cartridge will depend upon the liquid that is to be dispensed, to ensure that the cartridge material does not react or degrade in the presence of the liquid. Thenozzle assembly 4 may also be formed by injection moulding. Thearmature 3 or a proportion thereof may be of iron or other magnetic material. Further, thearmature 3 may be coated to ensure it does not react or degrade in the presence of the liquid. Advantageously thecartridge 2,armature 3 andnozzle assembly 3 are simple and inexpensive to manufacture and thus can be disposable. -
FIGS. 3 a and 3 b show, in section, a first embodiment of theliquid dispensing system 1 assembled and mounted in thebore 16 of thesolenoid coil 15. Corresponding reference numerals have been applied to corresponding parts. In this embodiment thearmature 3 has afluid flow path 26 that extends axially part way through the armature and then radially. Thus,aperture 27, formed in the base of thearmature 3, adjacent thenozzle assembly 4, is connected via theflow path 26 toaperture 28 formed in a circumferential side of thearmature 3, adjacent thereservoir 6. Thearmature ledge 18 is located around the periphery ofaperture 27 and thus thespring member 14 has a smaller diameter. Further, thereservoir 6 has aport 30 formed in its side wall for applying pressure or a vacuum to thereservoir 6. Thesolenoid coil 15 hasterminals 10 for connecting it to a control system of the dispensing apparatus (not shown). - In use, the
reservoir 6 is filled withliquid 31 and is sealed by thelid 24. InFIG. 3 a thecoil 15 is not activated and thus thespring member 14 urges thearmature 3 into the first position. In the first position thenozzle assembly 4 and thearmature 3 define therebetween a dispensingchamber 32 in thesecond chamber 7. Further, in the first position thearmature 3 is adapted such that it projects into thereservoir 6 such thataperture 28 is open to the liquid 31. Thus, the liquid 31 from the reservoir entersaperture 28, travels through thefluid flow path 26 and out ofaperture 27, and collects in the dispensingchamber 32. The liquid is prevented from draining from thenozzle 12 due to the surface tension formed at the free end of the dispensing bore 17. It will be appreciated that the form, and in particular the diameter, of thenozzle 12 is chosen to ensure that theparticular liquid 31 being dispensed is able to exhibit sufficient surface tension to be retained in the dispensingchamber 32. Thepressure port 30 may apply a vacuum to thereservoir 6 to allow a larger “head” of liquid in thereservoir 6 to be supported by the surface tension at the dispensingnozzle 12. Further, the exact location of thearmature 3 in the first position and the diameter of the dispensingchamber 32 is chosen so that a precise measured volume of liquid collects in the dispensingchamber 32, to ensure accurate and repeatable dispensing. - In
FIG. 3 b, electrical power has been applied to thecoil 15 by the dispensing apparatus resulting in a magnetic field, which has drawn thearmature 3 into a second position in which it abuts thenozzle assembly 4. In moving from the first position to the second position theaperture 28 is closed off from thereservoir 6 by the wall of thesecond chamber 7. Further, as thearmature 3 moves to the second position the volume of the dispensingchamber 32 is reduced which forces a measured quantity of liquid from the dispensingchamber 32 out of the dispensing bore 17. Thus, movement of the armature from the first position to the second position is an active dispensing stroke in which liquid is actively expelled thereby improving accuracy. - Once the liquid has been dispensed the electrical power to the
solenoid coil 15 is removed and thearmature 3 will be urged to return to the first position by thespring member 14. In moving from the second position to the first position, the volume of the dispensingchamber 32 increases, which leads to a decrease in pressure withinchamber 32. This decrease in pressure effectively pumps liquid 31 from thereservoir 6 into the dispensingchamber 32, once theaperture 28 is open to thereservoir 6. This ensures that the dispensingchamber 32 is reliably filled with liquid after each dispensing stroke and operation of the dispensing system does not have to rely solely on gravity to fill the dispensing chamber, which improves reliability. Thus, movement of thearmature 3 from the second position to the first position is a pumping stroke. However, it will be appreciated that during the pumping stroke, air will also be drawn in through the dispensing bore 17 and therefore the system will still rely on gravity to an extent to ensure the dispensingchamber 32 is completely filled. - In a modification (not shown) the pressure/
vacuum port 30 is omitted. Instead, the dispensing bore 17 is elongated with a length of capillary tubing, and thespring 14 is constructed so that the force acting on the armature returns it relatively slowly to the first position. The return force needs to be chosen so that the velocity of the armature creates sufficient force to draw in liquid from thereservoir 6 to the dispensingchamber 32, but not enough to overcome the surface tension at the capillary end of thebore 17, so that air is not drawn in. The spring force can be altered for different liquids according to their viscosity to achieve this result. Activation of the coil, however, will cause a more rapid movement of the armature, so that the pressure created in the dispensingchamber 32 is sufficient to overcome the surface tension and dispense the liquid. -
FIG. 4 shows a modification to thenozzle assembly 4 of the embodiment shown inFIGS. 3 a and 3 b, which also addresses this problem. InFIG. 4 , the pressure/vacuum port 30 is absent and thenozzle 12 incorporates a one-way “duck-bill”style valve 33. Thevalve 33 only permits flow out of the dispensing bore 17. As the dispensing bore 17 is not open to atmosphere, thedispensing system 1 does not rely on surface tension to retain a measured volume in the dispensingchamber 32. This obviates the need for the pressure/vacuum port 30. Further, during the pumping stroke, thevalve 33 prevents air entering the dispensingchamber 32 through the dispensing bore 17 and therefore the reduction in pressure in the dispensingchamber 32 will solely cause liquid 31 from thereservoir 6 to be drawn intochamber 32. This improves the accuracy and the repeatability of the dispensing device. In the embodiment ofFIGS. 1 to 4 it will be noted that when thecoil 15 has no electrical power (i.e., it is inactive) thenozzle 12 is open, so that it may be possible for liquid to leak out. In a further modification (not shown) thearmature 3 andspring 14 are arranged so that the spring force biases thearmature 3 to the position where it closes off the dispensing bore 17, and activation of thecoil 15 moves thearmature 3 away from thebore 17. Thespring 14 is then provided on the opposite end of thearmature 3, as a separate component. - In operation, activation of the
coil 15 moves thearmature 3 away from thebore 17 to allow liquid to flow into the dispensingchamber 32 from thereservoir 6. When thecoil 15 is de-activated thearmature 3 returns under the force of thespring 14 to dispense the liquid. - This has the advantage that, as well as preventing leakage when the cartridge is installed in the system, leakage is also prevented before the cartridge is installed. This means that the cartridge can be manufactured, filled with liquid, sealed and delivered to the point of use without fear of loss of liquid.
-
FIG. 5 shows a second embodiment of the invention having a modifiedarmature 3. The remainder of theliquid dispensing system 1 is the same as the first embodiment and corresponding reference numerals have been applied to corresponding parts. Thearmature 3 ofFIG. 5 does not have a machinedfluid flow path 26 through the body of thearmature 3. Instead, it is of a lesser diameter than thesecond chamber 7 such that a flow path is formed between thearmature 3 and the walls of thesecond chamber 7. As thearmature 3 is not machined, this makes it simpler and cheaper to manufacture. - In use, the
liquid dispensing system 1 of this embodiment operates in a similar manner to the previous embodiment in that liquid 31 collects in the dispensingchamber 32 when thearmature 3 is in the first position. Similarly, the surface tension of the liquid 31 at the free end of the dispensing bore 17 retains the liquid 31 in thechamber 32. Upon activation of thesolenoid coil 15, thearmature 3 is driven into the second position by the magnetic force, against the force of thespring member 14. This dispensing stroke forces the fluid 31 in the dispensingchamber 32 out of thenozzle 12. It will be appreciated that a certain amount of liquid will also be forced back into thereservoir 6 throughflow path 26. However, the area of theflow path 26 and the size of the dispensingchamber 32 when thearmature 3 is in the first position can be chosen so that a precise and repeatable quantity of liquid is expelled from thenozzle 12 during each dispensing stroke. During the pumping stroke, both liquid from thereservoir 6 and atmospheric air through the dispensing bore 17 will be drawn into the dispensingchamber 32. Thechamber 32 is then completely filled withliquid 31 by it flowing under gravity from thereservoir 6, through thefluid flow path 26. -
FIGS. 6 a, 6 b and 6 c show a third embodiment that includes a modifiedarmature 3 andsecond chamber 7. Thearmature 3 comprises a cylindrical body having acircumferential groove 34 therein, such that when thearmature 3 is in the first position (seeFIG. 6 a), thegroove 34 is open to thereservoir 6. Thesecond chamber 7 also has a groove in its inner wall that forms anintermediate chamber 35. Theintermediate chamber 35 is positioned such that when thearmature 3 is in the second position thegroove 34 aligns with thechamber 35. In the second position, liquid 31 is prevented from flowing freely from thereservoir 6 to theintermediate chamber 35 by aradial flange 36 of thearmature 3. - Upon first use, liquid 31 from the
reservoir 6 collects within thegroove 34 when thearmature 3 is in the first position. Activation of thesolenoid coil 15 draws thearmature 3 downwards into the second position against the force of thespring member 14. The liquid that has collected with thegroove 34 is drawn downwards with thearmature 3. In the second position, thegroove 34 is aligned with theintermediate chamber 35. Thus, the liquid in thegroove 34 flows freely into the intermediate chamber 35 (as shown inFIG. 6 b). Thus, in this embodiment the pumping stroke, in whichliquid 31 is urged from thereservoir 6, occurs when the armature moves from the first position to the second position. When thesolenoid coil 15 is deactivated, the armature returns to the first position under the force ofspring member 14. The liquid 31 transferred to theintermediate chamber 35 is then able to flow from thechamber 35 into the dispensingchamber 32. As shown inFIG. 6 c, the majority of the liquid collects in the dispensing bore 17 and the majority of the dispensingchamber 32 is filled with air. The liquid is held in the dispensing bore 17 by surface tension. The liquid is dispensed when thesolenoid coil 15 is activated once again and thearmature 3 moves to the second position. The resulting pressure from reduction in volume of the dispensingchamber 32 overcomes the surface tension and forces the liquid from the dispensing bore 17. The air in the dispensingchamber 32 is also forced out of thebore 17, which helps to ensure that all of the liquid is actively expelled from the dispensingchamber 32 and bore 17. Thus, movement of thearmature 3 from the first position to the second position is also an active dispensing stroke. Although, the first dispense from this embodiment requires two cycles of the armature 3 (i.e. thesolenoid coil 15 is activated and deactivated twice), it will be appreciated that liquid is dispensed on every cycle thereafter. - A fourth embodiment of the invention is shown in
FIGS. 7 a, 7 b and 7 c, in which there are modifications to thearmature 3, thesecond chamber 7 andnozzle assembly 4. Firstly, thearmature 3 comprises abody 37 of smaller diameter than thesecond chamber 7 and has an annularperipheral flange 38 that extends radially outward to a diameter that approaches the internal diameter of thesecond chamber 7. Thearmature 3 also carriesseals second chamber 7 includes an annularelastomeric inlet seal 42 mounted within thesecond chamber 7, adjacent the junction with thereservoir 6. Theinlet seal 42 prevents flow between itself and the wall of thesecond chamber 7 and has anaperture 43. Theseal 42 is comparable to the valve seat 8 shown inFIG. 1 . Thenozzle assembly 4 also has an annularelastomeric outlet seal 44 in thenozzle body 11, which surrounds the proximal end of the dispensing bore 17. Thespring member 14 has been omitted from these Figures for clarity, but would extend from thenozzle assembly body 11 andabut flange 38 of thearmature 3. - In
FIG. 7 a thearmature 3 is shown in the first position, wherein the dispensingchamber 32 is sealed from thereservoir 6 byseal 40 on thearmature 3 abutting theinlet seal 42. On activation of thesolenoid coil 15, thearmature 3 moves to the second position. Theseal 40 moves away from theinlet seal 40 and into sealing contact with theoutlet seal 44 on thenozzle assembly 4. This movement of thearmature 3 acts as a pumping stroke, drawingliquid 31 from thereservoir 6, past theflange 38 into the dispensing chamber 32 (as shown inFIG. 7 b). Deactivation of thesolenoid coil 15 causes thearmature 3 to return to the first position under the force of the spring member (not shown). Thus, seals 41 and 44 are separated, which allows a proportion of the liquid in the dispensingchamber 32 to flow into the dispensing bore 17. The liquid 31 is retained in the dispensing bore 17 by surface tension (seeFIG. 7 c). When thesolenoid coil 15 is activated again and thus thearmature 3 moves to the second position, a proportion of the liquid in the dispensing chamber is expelled from thenozzle 12. As with the previous embodiment, after the first cycle as described above, liquid is dispensed and pumped from thereservoir 6 on the same stroke of thearmature 3 from the first to the second position. - A fifth embodiment is shown in
FIGS. 8 a, 8 b and 8 c. In this embodiment thenozzle assembly 4 comprises anelongate nozzle 12 that first extends radially from anaperture 48 in thesecond chamber 7 and then axially, adjacent the coil 15 (when thesecond chamber 7 is mounted within the solenoid coil aperture 16). Thesecond chamber 7 includes anextension portion 45 that extends into thereservoir 6 and has anopen end 47 and aninlet aperture 46 in its side wall. Thesecond chamber 7 also includes ahollow guide member 50 having a cylindricalopen bore 51. Thearmature 3 comprises ahead portion 52 having asupport section 53 and aguide section 54, separated by ashoulder 55, depending axially therefrom. Theguide section 54 is received in thebore 51 of theguide member 50 and can axially slide therein. Anannular slider member 56 is slidably mounted on thesupport section 53 ofarmature 3. Thus, theslider member 56 can slide between thehead portion 52 andshoulder 55. Theslider member 56 has a series of circumferentially spaced axial channels 57 (seeFIG. 9 ) that allows liquid to flow through themember 56. -
FIG. 8 a shows thearmature 3 biased into the first position by the spring member (not shown) in which thehead 52 extends into theextension portion 45, adjacent thereservoir 6. Theslider member 56 abuts theshoulder 55 and as such, seals theinlet aperture 46.Liquid 31 from previous cycles is shown in the dispensingchamber 32 and the dispensing bore 17. Upon activation of thecoil 15 thearmature 3 is drawn into the second position where, in this embodiment, theslider member 56 abuts theguide member 50. This downward movement of thearmature 3 is the active dispensing stroke, which reduces the volume of the dispensingchamber 32 and therefore causes liquid 31 to be expelled from the dispensingchamber 32 and bore 17. As theslider member 56 seals theinlet aperture 46, movement of thearmature 3 can only force liquid out of the dispensingchamber 32 and bore 17 and therefore a precise and reliable volume is dispensed. Before the active dispensing stroke is complete (as shown inFIG. 8 b) thehead 52 abuts theslider member 56 and draws it downward with thearmature 3. In the second position theslider member 56 seals the outlet aperture 48 (as shown inFIG. 8 c). Thus, when thecoil 15 is deactivated and thearmature 3 is urged by the spring member (not shown) to return to the first position (the pumping stroke), no air can be drawn in through the dispensing bore 17 and therefore only liquid 31 fromreservoir 6 is drawn into the dispensingchamber 32 throughaperture 46. Before the pumping stroke is complete theslider member 56 abuts theshoulder 55 and is drawn upwards with thearmature 3 and returns to the position shown inFIG. 8 a for further cycles. - A sixth embodiment is shown in
FIGS. 10 a, 10 b and 10 c. The construction of theliquid dispensing system 1 in this embodiment is similar to the first embodiment except that thecartridge 2 includesthird section 59 which extends within an aperture of asecond coil 58 and has asecond nozzle 60 andsecond armature 61 mounted within. The second coil hasterminals 62 for connecting it to the control system of the dispensing apparatus (not shown). Thesecond armature 61 has a bore therethrough in which is mounted a one-way valve 63. Thethird section 59 defines asecond dispensing chamber 64 having a second dispensing bore 65. Operation of thefirst armature 3 is the same as described for the first embodiment, except that downward movement of thearmature 3 performs a dosing stroke, in which a measured amount of liquid is transferred through the one-way valve 63 of thesecond armature 61, into the second dispensing chamber 64 (as shown inFIG. 10 b). Then, thesecond coil 58 can be activated to move thesecond armature 61 through an active dispensing stroke from a first position in which it is adjacent thenozzle 4, downward to a second position where it abuts thesecond nozzle 60. During the active dispensing stroke, the liquid in thesecond dispensing chamber 64 is expelled from the second dispensing bore 65 (as shown inFIG. 10 c). The solenoid coils 15 and 58 can then be deactivated so that thefirst armature 3 returns to the first position under the force ofspring member 14 and the second armature returns to its first position under the force of a return spring (not shown). As a measured quantity ofliquid 31 is transferred between dispensingchambers reservoir 6. This is advantageous as the volume of liquid to be dispensed is unaffected by the change in hydrostatic pressure as the quantity of fluid in the reservoir decreases. The use of twoarmatures chambers reservoir 6. By appropriately sequencing the activation of the solenoid coils 15, 58 a fast and reliable dispense rate can be achieved. - It will be appreciated that the pressure/vacuum source may be incorporated in any of the embodiments shown or equally omitted, depending upon the application of the liquid dispensing system and the type of liquid being dispensed. The pressure/vacuum source can be used to allow greater control of the amount of liquid being dispensed. For example, a vacuum can be applied to reduce the pressure in the
reservoir 6, thereby impeding the flow of liquid from thereservoir 6. Alternatively, pressure could be applied to urge liquid from thereservoir 6, to promote rapid and complete filling of the dispensechamber 32, for example. The “duck-bill”valve 33 or any other suitable one-way valve may also be included in any of the embodiments. The armature or nozzle assembly may be coated in or comprise a material suitable for use with the liquid being dispensed which, in particular, may be a hydrophobic material to promote full expulsion from the dispensingchamber 32 and bore 17 on the active dispensing stroke. In all the embodiments, thespring member 14 may be omitted and thearmature 3 may be returned to its first position by a reversal of the magnetic field generated bycoil 15. - It will also be appreciated that the modifications described in relation to
FIGS. 3 and 4 , (the choice of the spring force dependent on the viscosity of the liquid to ensure filling of the dispensing chamber without drawing in air, and the reversal of the normal position of the armature) could equally be applied to the embodiments ofFIGS. 5 to 10 .
Claims (34)
1. A liquid dispensing system comprising a cartridge (2) in which liquid to be dispensed is retained and at least one solenoid assembly, the solenoid assembly comprising a coil (15) and an armature (3), the armature (3) being movably mounted within the cartridge (2) and the coil (15) being separate from the cartridge (2), movement of the armature (3) acting to expel liquid from the cartridge (2).
2. A liquid dispensing system according to claim 1 , in which the cartridge (2) is disposable.
3. A liquid dispensing system according to claim 1 , in which the cartridge (2), when assembled, comprises a cartridge body (5), the armature (3), a return spring (14) for the armature (3) and a nozzle assembly (4).
4. A liquid dispensing system according to claim 3 , in which the armature (3) is biased by the return spring (14) towards a first position, and towards a second position by activation of the coil (15).
5. A liquid dispensing system according to claim 1 , in which the armature (3) slides within the cartridge (2).
6. A liquid dispensing system according to claim 4 , in which in the first position the armature (3) closes off flow through the nozzle assembly (4).
7. A liquid dispensing system according to claim 6 , in which activation of the coil (15) moves the armature (3) to allow flow through the nozzle assembly (4), and movement of the armature in response to the return spring (14) dispenses the liquid.
8. A liquid dispensing system according to claim 3 , in which the return spring (14) is a separate component from the cartridge (2), armature (3) and nozzle assembly (4).
9. A liquid dispensing system according to claim 4 , in which in the first position the armature (3) allows flow through the nozzle assembly (4).
10. A liquid dispensing system according to claim 9 , in which activation of the coil (15) moves the armature (3) to dispense the liquid.
11. A liquid dispensing system according to claim 3 , in which the return spring (14) is formed integrally with the nozzle assembly (4).
12. A liquid dispensing system according to claim 1 , in which the armature (3) comprises iron or other magnetic material.
13. A liquid dispensing system according to claim 1 , in which the cartridge (2) is disposed within the coil (15) when the cartridge (2) is mounted in the dispensing system (1).
14. A liquid dispensing system according to claim 1 , in which the cartridge (2) has two chambers, of which the first chamber (6) is a reservoir for the liquid and the second chamber (7) retains the armature (3).
15. A liquid dispensing system according to claim 14 , in which the second chamber (7) is disposed within the coil (15) when the cartridge (2) is mounted in the dispensing system (1).
16. A liquid dispensing system according to claim 14 , in which the armature (3) defines a dispensing chamber (32) in the second chamber (7) in which the liquid to be dispensed collects.
17. A liquid dispensing system according to claim 16 , in which the armature (3) has a fluid flow path (26) for transferring fluid from the reservoir (6) to the dispensing chamber (32).
18. A liquid dispensing system according to claim 17 , in which the fluid flow path (26) comprises a bore through the armature (3).
19. A liquid dispensing system according to claim 17 , in which the fluid flow path (26) comprises an annular groove in the outer surface of the armature (3).
20. A liquid dispensing system according to claim 16 , in which axial movement of the armature (3) in one direction dispenses the liquid and in the other direction, pumps liquid from the reservoir (6) into dispensing chamber (32).
21. A liquid dispensing system according to claim 3 , in which the nozzle assembly (4) includes a one-way valve.
22. A liquid dispensing system according to claim 21 , in which the one-way valve is a “duck-bill” valve (33).
23. A liquid dispensing system according to claim 1 , in which the dispensing system (1) includes one solenoid coil (15).
24. A liquid dispensing system according to claim 1 , in which the dispensing system (1) includes two solenoid coils (15, 58).
25. A liquid dispensing system according to claim 24 , in which the cartridge (2) contains two armatures (3, 61) and two dispensing chambers (32, 64).
26. A liquid dispensing system according to claim 14 , in which reservoir (6) has a pressure/vacuum source (30) attached thereto.
27. A liquid dispensing system according to claim 1 , in which the cartridge (2) includes a lid (24) having a moulded hinge.
28. A liquid dispensing system according to claim 3 , in which the nozzle assembly (4) is mounted with the cartridge (2) by interference fit.
29. A liquid dispensing system according to claim 3 , in which the nozzle assembly (4) is mounted with the cartridge (2) with adhesive.
30. A liquid dispensing system according to claim 3 , in which the nozzle assembly (4) is integrally moulded with the cartridge (2).
31. A liquid dispensing system according to claim 3 , in which the nozzle assembly (4) has a nozzle (12) and a shroud (13).
32. A liquid dispensing system according to claim 31 , in which the nozzle (12) has a hydrophobic coating to aid complete expulsion of liquid therefrom.
33. A liquid dispensing system according to claim 16 , in which dispensing chamber (32) has a hydrophobic coating to aid complete expulsion of liquid therefrom.
34. A liquid dispensing system according to claim 1 , adapted to dispense quantities of liquid in the order of microlitres.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0424313.5 | 2004-11-03 | ||
GBGB0424313.5A GB0424313D0 (en) | 2004-11-03 | 2004-11-03 | Liquid dispensing system |
PCT/GB2005/004239 WO2006048643A1 (en) | 2004-11-03 | 2005-11-03 | Liquid dispensing system |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080135583A1 true US20080135583A1 (en) | 2008-06-12 |
Family
ID=33515969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/795,425 Abandoned US20080135583A1 (en) | 2004-11-03 | 2005-11-03 | Liquid Dispensing System |
Country Status (4)
Country | Link |
---|---|
US (1) | US20080135583A1 (en) |
EP (1) | EP1812800A1 (en) |
GB (1) | GB0424313D0 (en) |
WO (1) | WO2006048643A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130037578A1 (en) * | 2010-04-01 | 2013-02-14 | Behzad MORTAZAVI | Inductively operated fluid dispensing device |
US8459509B2 (en) * | 2006-05-25 | 2013-06-11 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US8550131B1 (en) | 2013-01-02 | 2013-10-08 | Liquid Squeeze, LLC | Liquid dispensing device, system and method |
US8580568B2 (en) | 2011-09-21 | 2013-11-12 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
US8752732B2 (en) | 2011-02-01 | 2014-06-17 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
US8932543B2 (en) | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
CN104412075A (en) * | 2012-05-08 | 2015-03-11 | 霍夫曼-拉罗奇有限公司 | Cartridge for dispensing a fluid |
US9518899B2 (en) | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2374541A1 (en) * | 2010-04-06 | 2011-10-12 | Symbion Medical Systems Sàrl | Disposable dispensing cartridge for medical assay instrumentation |
EP2662138A1 (en) * | 2012-05-08 | 2013-11-13 | Roche Diagniostics GmbH | Microfluidic dispenser, cartridge and analysis system for analyzing a biological sample |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3395740A (en) * | 1965-10-22 | 1968-08-06 | Hazel L. Sutcliffe | Liquid dispensing nozzle spout structure |
US4015755A (en) * | 1975-12-12 | 1977-04-05 | Edward Lerner | Electromagnetically actuatable metering valve for successive delivery of measured volumes of fluid from a fluid reservoir |
US4518105A (en) * | 1981-03-26 | 1985-05-21 | Dagma Deutsche Automaten-Und Getrankemaschinen Gmbh & Co., Ltd. | Method of and device for dispensing viscous concentrates of variable viscosity in accurately metered quantities of variable volume |
US4651862A (en) * | 1985-06-10 | 1987-03-24 | Greenfield Jr Irving E | Dual temperature beverage dispenser with removable operating module |
US4844868A (en) * | 1985-06-18 | 1989-07-04 | Kabushiki Kaisha Toshiba | Automatic chemical analysis reagent distribution and analysis apparatus |
US5154325A (en) * | 1991-01-09 | 1992-10-13 | Ryder International Corporation | Solution delivery nozzle and system with antimicrobial features |
US5816445A (en) * | 1996-01-25 | 1998-10-06 | Stainless Steel Coatings, Inc. | Method of and apparatus for controlled dispensing of two-part bonding, casting and similar fluids and the like |
US6193933B1 (en) * | 1997-10-27 | 2001-02-27 | Hitachi, Ltd. | Automatic analysis apparatus |
US6192945B1 (en) * | 1997-08-11 | 2001-02-27 | Ventana Medical Systems, Inc. | Fluid dispenser |
US6216966B1 (en) * | 1996-10-30 | 2001-04-17 | The Procter & Gamble Company | Dispensing devices |
US6402841B1 (en) * | 1997-02-21 | 2002-06-11 | Akzo Nobel N.V. | Glue application device with glue conduit surrounding hardener conduit |
US20050035156A1 (en) * | 2003-08-11 | 2005-02-17 | Michael Hersch | Fluid dispensing apparatus |
US20050042170A1 (en) * | 2003-02-14 | 2005-02-24 | The Brigham And Women's Hospital, Inc. | Method and device for generating mists and medical uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB970396A (en) * | 1961-04-06 | 1964-09-23 | Fisher & Ludlow Ltd | Delivery device for controlling the flow of liquids |
DE3131650C2 (en) * | 1981-03-26 | 1985-02-14 | DAGMA Deutsche Automaten- und Getränkemaschinen GmbH & Co KG, 2067 Reinfeld | Device for dispensing viscous concentrates of variable viscosity in precisely metered amounts of variable volume, especially for vending machines |
AU2519184A (en) * | 1983-03-21 | 1984-09-27 | Miles Laboratories Inc. | Microdroplet dispensing apparatus |
DE4202561A1 (en) * | 1992-01-30 | 1993-08-05 | Boehringer Mannheim Gmbh | DEVICE FOR DELIVERING AN ANALYZING LIQUID |
-
2004
- 2004-11-03 GB GBGB0424313.5A patent/GB0424313D0/en not_active Ceased
-
2005
- 2005-11-03 WO PCT/GB2005/004239 patent/WO2006048643A1/en active Application Filing
- 2005-11-03 US US11/795,425 patent/US20080135583A1/en not_active Abandoned
- 2005-11-03 EP EP05800070A patent/EP1812800A1/en not_active Withdrawn
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3395740A (en) * | 1965-10-22 | 1968-08-06 | Hazel L. Sutcliffe | Liquid dispensing nozzle spout structure |
US4015755A (en) * | 1975-12-12 | 1977-04-05 | Edward Lerner | Electromagnetically actuatable metering valve for successive delivery of measured volumes of fluid from a fluid reservoir |
US4518105A (en) * | 1981-03-26 | 1985-05-21 | Dagma Deutsche Automaten-Und Getrankemaschinen Gmbh & Co., Ltd. | Method of and device for dispensing viscous concentrates of variable viscosity in accurately metered quantities of variable volume |
US4651862A (en) * | 1985-06-10 | 1987-03-24 | Greenfield Jr Irving E | Dual temperature beverage dispenser with removable operating module |
US4844868A (en) * | 1985-06-18 | 1989-07-04 | Kabushiki Kaisha Toshiba | Automatic chemical analysis reagent distribution and analysis apparatus |
US5154325A (en) * | 1991-01-09 | 1992-10-13 | Ryder International Corporation | Solution delivery nozzle and system with antimicrobial features |
US5816445A (en) * | 1996-01-25 | 1998-10-06 | Stainless Steel Coatings, Inc. | Method of and apparatus for controlled dispensing of two-part bonding, casting and similar fluids and the like |
US6216966B1 (en) * | 1996-10-30 | 2001-04-17 | The Procter & Gamble Company | Dispensing devices |
US6402841B1 (en) * | 1997-02-21 | 2002-06-11 | Akzo Nobel N.V. | Glue application device with glue conduit surrounding hardener conduit |
US6192945B1 (en) * | 1997-08-11 | 2001-02-27 | Ventana Medical Systems, Inc. | Fluid dispenser |
US6193933B1 (en) * | 1997-10-27 | 2001-02-27 | Hitachi, Ltd. | Automatic analysis apparatus |
US20050042170A1 (en) * | 2003-02-14 | 2005-02-24 | The Brigham And Women's Hospital, Inc. | Method and device for generating mists and medical uses thereof |
US20050035156A1 (en) * | 2003-08-11 | 2005-02-17 | Michael Hersch | Fluid dispensing apparatus |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9518899B2 (en) | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
US8459509B2 (en) * | 2006-05-25 | 2013-06-11 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US9914124B2 (en) | 2006-05-25 | 2018-03-13 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US20130037578A1 (en) * | 2010-04-01 | 2013-02-14 | Behzad MORTAZAVI | Inductively operated fluid dispensing device |
US8789727B2 (en) * | 2010-04-01 | 2014-07-29 | Alpimed Sarl | Inductively operated fluid dispensing device |
US9016526B2 (en) | 2011-02-01 | 2015-04-28 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
US8752732B2 (en) | 2011-02-01 | 2014-06-17 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
US8580568B2 (en) | 2011-09-21 | 2013-11-12 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
US9005980B2 (en) | 2011-09-21 | 2015-04-14 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
US8932543B2 (en) | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
US10295444B2 (en) | 2011-09-21 | 2019-05-21 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
CN104412075A (en) * | 2012-05-08 | 2015-03-11 | 霍夫曼-拉罗奇有限公司 | Cartridge for dispensing a fluid |
US8550131B1 (en) | 2013-01-02 | 2013-10-08 | Liquid Squeeze, LLC | Liquid dispensing device, system and method |
Also Published As
Publication number | Publication date |
---|---|
GB0424313D0 (en) | 2004-12-01 |
EP1812800A1 (en) | 2007-08-01 |
WO2006048643A1 (en) | 2006-05-11 |
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Owner name: NORGREN LIMITED, UNITED KINGDOM Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CASWELL, MARK;NIGHY, RICHARD;REEL/FRAME:019747/0321;SIGNING DATES FROM 20070620 TO 20070706 |
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STCB | Information on status: application discontinuation |
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