US20080228201A1 - Mitral valve repair system and method for use - Google Patents
Mitral valve repair system and method for use Download PDFInfo
- Publication number
- US20080228201A1 US20080228201A1 US12/129,574 US12957408A US2008228201A1 US 20080228201 A1 US20080228201 A1 US 20080228201A1 US 12957408 A US12957408 A US 12957408A US 2008228201 A1 US2008228201 A1 US 2008228201A1
- Authority
- US
- United States
- Prior art keywords
- catheter
- fastener
- suture
- leaflet
- therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0467—Instruments for cutting sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0482—Needle or suture guides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00367—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like
- A61B2017/00371—Multiple actuation, e.g. pushing of two buttons, or two working tips becoming operational
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
- A61B2017/00783—Valvuloplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0445—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors cannulated, e.g. with a longitudinal through-hole for passage of an instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0446—Means for attaching and blocking the suture in the suture anchor
- A61B2017/0448—Additional elements on or within the anchor
- A61B2017/0451—Cams or wedges holding the suture by friction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0464—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors for soft tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
- A61B2017/0472—Multiple-needled, e.g. double-needled, instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
- A61B2017/0488—Instruments for applying suture clamps, clips or locks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22052—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation eccentric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22065—Functions of balloons
- A61B2017/22069—Immobilising; Stabilising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/30—Surgical pincettes without pivotal connections
- A61B2017/306—Surgical pincettes without pivotal connections holding by means of suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
Definitions
- the heart is a hollow muscular organ having four pumping chambers: the left atrium, the left ventricle, the right atrium and the right ventricle.
- the atria are isolated from their respective ventricles by one-way valves located at the respective atrial-ventricular junctions. These valves are identified as the mitral (or bicuspid) valve on the left side of the heart, and tricuspid valve on the right side of the heart.
- the exit valves from the left and right ventricles are identified as the aortic and pulmonary valves, respectively.
- valves of the heart are positioned in valvular annuluses that comprise dense fibrous rings attached either directly or indirectly to the atrial and ventricular muscle fibers.
- Valve leaflets comprising flexible collagenous structures are attached to, and extend inwardly from, the annuluses to meet at coapting edges.
- the aortic, tricuspid and pulmonary valves each have three leaflets, while the mitral valve only has two. In normal operation, the leaflets of the mitral valve open as left ventricle dilates thereby permitting blood to flow from the left atrium into the left ventricle. The leaflets then coapt (i.e.
- the tricuspid valve regulates flow from the right atrium into the right ventricle, and the pulmonary valve regulates blood exiting the right ventricle.
- Heart valve stenosis is a condition in which the valve does not open properly.
- Insufficiency is a condition in which the valve does not close properly.
- Insufficiency of the mitral valve most common because of the relatively high fluid pressures in the left ventricle, results in mitral valve regurgitation (“MR”), a condition in which blood reverses its intended course and flows “backward” from the left ventricle to the left atrium during ventricular contractions.
- MR mitral valve regurgitation
- a number of surgical techniques have been developed to repair degraded or otherwise incompetent heart valves.
- a common procedure involves replacement of a native aortic or mitral valve with a prosthetic heart valve. These procedures require the surgeon to gain access to the heart through the patient's chest (or possibly percutaneously), surgically remove the incompetent native heart valve and associated tissue, remodel the surrounding valve annulus, and secure a replacement valve in the remodeled annulus. While such procedures can be very effective, there are shortcomings associated with such replacement valves. For example, the invasive nature of the implantation procedure typically results in substantial patient discomfort and requires patients to remain hospitalized for extended recovery periods. In addition, the two basic types of commercially available replacement valves, mechanical valves and tissue valves, each have shortcomings of their own.
- tissue valves typically offer extended operational lifetimes, but the patient is usually required to maintain a regimen of anti-coagulant drugs for the remainder of his or her life.
- Tissue valves typically offer a higher degree of acceptance by the body which reduces or eliminates the need for anti-coagulants.
- the operational lifetimes of tissue valves is typically shorter than mechanical valves and thus may require a subsequent replacement(s) during the patient's lifetime.
- Valvular remodeling can be accomplished by implanting a prosthetic ring (a.k.a. “annuloplasty ring”) into the valve annulus to reduce and/or stabilize the structure of the annulus in order to correct valvular insufficiency.
- Annuloplasty rings are typically constructed of a resilient core covered with a fabric sewing material. Annuloplasty procedures can be performed alone, or they can be performed in conjunction with other procedures such as leaflet repair. Although such annuloplasty procedures have become popular and well accepted, reshaping the surrounding annulus and traditional leaflet repairs do not always lead to optimum leaflet coaptation. As a result, some patients may still experience residual mitral valve regurgitation following such annuloplasty procedures.
- a recently developed technique known as a “bow-tie” repair has also been advocated for repairing insufficient heart valves, in particular the mitral valve.
- the mitral valve bow-tie technique involves suturing the anterior and posterior leaflets together near the middle of their coapting edges, thereby causing blood to flow through two newly formed openings. While this does reduce the volume of blood that can flow from the atrium to the ventricle, this loss is compensated by improved leaflet coaptation which reduces mitral regurgitation.
- This process as originally developed by Dr. Ottavio Alfieri involved arresting the heart and placing the patient on extracorporeal bypass and required invasive surgery to access and suture the leaflets together. More recently, however, some have advocated a “beating heart” procedure in which the heart is accessed remotely and remains active throughout the bow-tie procedure.
- the associated device consists of a forceps-like grasper used to grasp and hold the mitral valve leaflets in a coapted position prior to the connecting step. Since the mitral valve leaflets curve toward and slightly into the left ventricular cavity at their mating edges, the grasper device is passed through a sealed aperture in the apex of the left ventricle.
- the edges of the mating mitral valve leaflets are then grasped and held together, and subsequently a fastening device such as a clip or suture is utilized to fasten them.
- a fastening device such as a clip or suture is utilized to fasten them.
- the Mehmet Oz disclosure also discloses teeth on the grasper device that are linearly slidable with respect to one another so as to permit alignment of the mitral valve leaflets prior to fastening. Since the procedure is done on a beating heart, it will be readily understood that the pressures and motions within the left ventricle and mitral valve leaflets are severe and render Dr. Oz's procedure very skill-intensive.
- the present invention solves the problem of effectively stabilizing at least one tissue portion in vivo. Additionally, the present invention provides a device capable of delivering a fastener to the stabilized tissue portion through a catheter from a remote insertion location.
- the present invention is directed to a system for repairing tissue within the heart of a patient and includes a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying at least one suture to the tissue, and a fastener catheter capable of attaching at least one fastener to the suture.
- the therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter.
- the present invention pertains to a system for repairing tissue within the heart of a patient and comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter having at least one needle lumen in communication with at least one needle port positioned therein, at least one needle positioned within the needle lumen, and a fastener catheter having at least one fastener detachably coupled thereto.
- the fastener catheter includes at least one cutting member.
- the present invention discloses a system for repairing tissue within the heart of a patient and includes a guide wire capable of being inserted into the patient and advanced through a circulatory pathway, a therapy catheter attachable to the guide wire and capable of applying at least one suture to the tissue, and a fastener catheter attachable to the guide wire and capable of attaching at least one fastener to the suture.
- the present invention pertains to a guide catheter for delivering a tissue repair device to tissue located within the heart of a patient and comprises an outer wall defining an outer wall lumen, a directing lumen capable of receiving a steering device therein and a flexible support device positioned within the outer wall lumen.
- the present invention discloses a catheter for delivering a suture to tissue within the heart of a patient and includes an elongated body having a distal end, at least one suction recess formed on the distal end, at least one needle port located proximate to the suction recess, at least one needle lumen having at least one needle positioned therein in communication with the needle port, at least one needle receiving port having at least one needle catch located therein positioned proximate to the suction recess, and at least one actuator member in communication with the needle.
- the present invention is directed to a catheter for delivering a suture to tissue within the heart of a patient and comprises an elongated body having a distal end with at least one suction recess formed thereon, at least one needle port located proximate to the suction recess, at least one needle lumen having at least one detachable needle attached to suture material positioned therein and in communication with the needle port, at least one needle receiving port located proximate to the suction recess, at least one needle trap capable of receiving the detachable needle positioned within the needle receiving port, and at least one actuator member in communication with the needle.
- the present invention pertains to a device for applying a fastener to suture material attached to tissue within the body of a patient and includes a catheter body having a proximal end and a distal end, an inner body defining a suture recess and an actuation recess, and a movable sleeve defining a deployment lumen.
- the suture recess on the inner body is in communication with a fastener lumen capable of receiving a fastener therein.
- the actuation recess is in communication with an actuation lumen formed in the inner body.
- the deployment lumen formed in the movable sleeve is sized to receive the inner body therein and includes a cutting recess having a cutting member located proximate thereto.
- the present invention is directed to a fastener attachable to suture material and comprises a fastener body having at least one attachment lumen formed therein and at least one engagement member attached to the fastener body wherein the engagement member is capable of engaging and retaining the suture material.
- the engagement member defines an engagement aperture which is in communication with the attachment lumen.
- the attachment lumen is capable of receiving at least one suture therein.
- the present invention also discloses various methods of repairing heart valve tissue within the body of a patient.
- a method of repairing tissue within the heart of a patient which includes advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with the therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and joining the first and second leaflets by reducing the distance between the first and second sutures.
- An alternate method of repairing tissue within the heart of a patient comprises advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with said therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and removing the therapy catheter from the guide catheter.
- a fastener catheter is positioned over the first and second suture and advanced through the guide catheter to the heart valve. Once positioned, the first and second leaflets are joined by reducing the distance between the first and second sutures and a fastener is deployed from the fastener catheter.
- FIG. 1 shows a perspective view of an embodiment of the guide catheter of the present invention
- FIG. 2 shows a cross-sectional view of an embodiment of the guide catheter of the present invention
- FIG. 3 shows a cross-sectional view of an alternate embodiment of the guide catheter of the present invention
- FIG. 4 shows a cross-sectional view of the embodiment of the guide catheter shown in FIG. 3 ;
- FIG. 5 shows a perspective view of an embodiment of the therapy catheter of the present invention
- FIG. 6 shows an embodiment of the therapy device handle of the present invention
- FIG. 7 shows an perspective view of an embodiment of the elongated body of the present invention having a suture attachment tip attached thereto;
- FIG. 8A shows a cross-sectional view of an embodiment of the elongated body of the present invention
- FIG. 8B shows a cross sectional view of an alternate embodiment of the elongated body of the present invention.
- FIG. 8C shows a side cross-sectional view of the embodiment of the elongated body shown in FIG. 8B ;
- FIG. 9 shows a top cross-sectional view of an embodiment of the elongated body of the present invention.
- FIG. 10 shows a side cross-sectional view of the embodiment of the elongated body shown in FIG. 9 prior to actuation
- FIG. 11 shows a side cross-sectional view of an embodiment of the elongated body shown in FIG. 10 during actuation;
- FIG. 12 shows a side cross-sectional view of an embodiment of the elongated body shown in FIG. 10 following actuation
- FIG. 13 shows another side cross-sectional view of an embodiment of the elongated body shown in FIG. 10 during actuation;
- FIG. 14 shows another side cross-sectional view of an embodiment of the elongated body shown in FIG. 10 following actuation
- FIG. 15 shows a top cross-sectional view of an alternate embodiment of the elongated body of the present invention.
- FIG. 16 shows a side cross-sectional view of the embodiment of the elongated body shown in FIG. 15 prior to actuation;
- FIG. 17 shows a side cross-sectional view of an embodiment of the elongated body shown in FIG. 15 during actuation;
- FIG. 18 shows a side cross-sectional view of an embodiment of the elongated body shown in FIG. 15 following actuation
- FIG. 19 shows a perspective view of an embodiment of the fastener catheter of the present invention.
- FIG. 20 shows an embodiment of the fastener catheter handle of the present invention
- FIGS. 21 a and 21 b show a perspective view of the components of the fastener tip of the present invention
- FIG. 22 shows a perspective view of the fastener tip of the present invention having a fastener attached thereto;
- FIG. 23 shows a side view of an embodiment of the fastener of the present invention.
- FIG. 24 shows a side view of the fastener of the present invention attached to suture material
- FIG. 25 shows a perspective view of a guidewire traversing the mitral valve within a heart
- FIG. 26 shows a perspective view of a guide catheter positioned proximate to the mitral valve within a heart
- FIG. 27 shows a perspective view of a therapy catheter advancing through a guide catheter to a position proximate to the mitral valve of a heart
- FIG. 28 shows a perspective view of a therapy catheter stabilizing a first leaflet of the mitral valve of a heart
- FIG. 29 shows a perspective view of the first leaflet of the mitral valve having a suture applied thereto
- FIG. 30 shows a perspective view of a therapy catheter stabilizing a second leaflet of the mitral valve of a heart
- FIG. 31 shows a perspective view of the first and second leaflets of the mitral valve having sutures applied thereto;
- FIG. 32 shows a perspective view of a fastener catheter advancing through a guide catheter to a position proximate to the mitral valve of a heart
- FIG. 33 shows a perspective view of the fastener catheter of the present invention applying a fastener to suture material attached to the mitral valve;
- FIG. 34 shows a perspective view of the fastener applied to suture material attached to the first and second leaflet of the mitral valve
- FIG. 35 shows a perspective view of another embodiment of the present invention wherein a dilator is used to introduce the guide catheter onto the left atrium;
- FIG. 36 shows a perspective view of the dilator of the present embodiment traversing the atrial septum
- FIG. 37 shows a perspective view of the guide catheter of the present embodiment positioned within the left atrium proximate to the mitral valve
- FIG. 38 shows a perspective view of an alternate embodiment of the therapy catheter advanced through the guide catheter to the mitral valve
- FIG. 39 shows a perspective view of the embodiment of the therapy catheter shown in FIG. 38 having an inflatable positioning balloon positioned thereon inflated;
- FIG. 40 shows a perspective view of the embodiment of the therapy catheter shown in FIG. 38 engaging a first leaflet
- FIG. 41 shows a perspective view of the first leaflet of the mitral valve having a suture attached thereto
- FIG. 42 shows a perspective view of the embodiment of the therapy catheter shown in FIG. 38 engaging the second leaflet of the mitral valve
- FIG. 43 shows a perspective view of the first and second leaflets of the mitral valve having sutures attached thereto.
- FIG. 44 shows another perspective view of the first and second leaflets of the mitral valve having sutures attached thereto.
- the mitral valve repair system of the present invention is designed for use in a surgical treatment of bodily tissue.
- the exemplary mitral valve repair system disclosed herein is designed to minimize trauma to the patient before, during, and subsequent to a minimally invasive surgical procedure while providing improved tissue stabilization and enhanced placement of a fastening device thereon.
- the mitral valve repair system of the present invention includes a guide catheter capable of being introduced into body of a patient and advanced to an area of interest, a therapy catheter capable of traversing or otherwise engaging the guide catheter and applying a suture to a repair site, and a fastener catheter capable of applying a fastening device to the attached suture.
- the various components of the present invention may be used individually.
- the therapy catheter, the fastener catheter, or both may be coupled to a guidewire and advanced to a repair site in vivo without the use of the guide catheter.
- the mitral valve repair system of the present invention is useful in repairing dysfunctional mitral valve tissue by stabilizing discreet valvular tissue pieces and deploying a fastening device therethrough.
- the mitral valve repair system may be used to repair tissue throughout a patient's body as desired.
- the present invention may also be used to repair arterial septal defects (ASD), ventricular septal defects (VSD), and defects associated with patent foramen ovale (PFO).
- ASD arterial septal defects
- VSD ventricular septal defects
- PFO patent foramen ovale
- FIGS. 1-4 show various illustrations of the guide catheter of the present invention.
- the guide catheter 10 comprises a guide body 12 having a proximal end 14 and a distal end 16 .
- the guide catheter 10 of the present invention may be manufactured from a variety of materials, including, without limitation, various plastics, thermoplastics, silicones, elastomers, ceramics, composite materials, or various combinations of the aforementioned materials.
- the guide catheter 10 may be manufactured in various lengths and widths as desired by the user.
- FIGS. 2-4 show various embodiments of the guide catheter 10 .
- the guide catheter 10 includes an outer wall 18 defining at least one internal lumen 20 .
- the outer wall 18 defines an internal lumen 20 and includes at least one directing lumen 22 formed therein.
- the directing lumen 22 is sized to receive a guidewire (not shown) or steering device (not shown) therein.
- at least one flexible support structure such as a coiled wire support (not shown) may be embedded within the outer wall 18 of the guide catheter 10 .
- FIG. 5 shows a perspective view of an embodiment of the therapy catheter 30 of the present invention.
- the therapy catheter 30 includes an elongated body 32 having a therapy device handle 34 located at the proximal end and a suture attachment tip 36 located at the distal end.
- the elongated body 32 may be manufactured in a variety of shape, sizes, lengths, widths, and biologically-compatible materials as desired.
- FIG. 6 shows a more detailed illustration of the therapy device handle 34 of the present invention.
- the therapy device handle 34 comprises a handle body 38 having at least a suction connector 40 and a elongated body receiver 42 attached thereto.
- the suction connector 40 is capable of coupling to a vacuum source (not shown).
- the elongated body receiver 42 is capable of receiving the elongated body 32 ( FIG. 5 ) thereon.
- a first actuator 44 is located within a first actuator recess 46 formed on the handle body 38 .
- a second actuator 48 is positioned within a second actuator recess 50 formed in the handle body 38 . As shown in FIG.
- a suction actuator 52 configured to open or close the fluid path between suction connector 40 and elongated body receiver 42 , may be located within a suction actuator recess 54 proximal to the first and second actuators 44 , 48 .
- FIGS. 7-10 show various illustrations of the elongated body 32 and the suture attachment tip 36 of the present invention.
- the elongated body 32 includes a suction recess 56 having a first needle port 58 A and a second needle port 58 B located proximate thereto.
- the elongated body 32 or the suture attachment tip 36 may include a guidewire port 60 capable of receiving a guidewire 62 .
- FIG. 8A shows a cross sectional view of the elongated body 32 .
- the elongated body 32 comprises an outer wall 64 defining a suction lumen 66 .
- the suction lumen 66 is in fluid communication with the suction recess 56 ( FIG.
- a first needle lumen 68 having a first needle 70 located therein may be formed in or otherwise positioned proximate to the outer wall 64 of the elongated body 32 .
- a second needle lumen 72 having a second needle 74 located therein may be formed in or otherwise positioned proximate to the outer wall 64 of the elongated body 32 .
- the first and second needles 70 , 74 are coupled to or otherwise in communication with the first and second actuators 44 , 48 located on the therapy device handle 34 ( FIG. 6 ).
- first and second actuators 44 , 48 results in the longitudinal movement of the first and second needles 70 , 74 thereby permitting the first and second needles, 70 , 74 to extend from and retract into the first and second needle lumens 68 , 72 .
- first and second needles 70 , 74 may be capable of individual or simultaneous movement.
- a first suture lumen 76 having a first suture 78 located therein and a second suture lumen 80 having a second suture 82 located therein may be formed within or located proximate to the outer wall 64 of the elongated body 32 .
- a guidewire lumen 84 sized to receive guidewire 62 therein may be positioned within or proximate to the outer wall 64 of the elongated body 32 and may be in communication with the guidewire port 60 formed on the suture attachment tip 36 .
- FIGS. 8B-8C show various illustrations of an alternate embodiment of the present invention, wherein an inflatable positioning balloon 252 is positioned on the outer wall 64 of the elongated body 32 .
- the inflatable positioning balloon 252 is in fluid communication with an inflation lumen 84 ′ positioned within the elongated body 32 .
- the inflation lumen 84 ′ may be in fluid communication with an inflation source in ways known to those skilled in the art and may be attached to or otherwise in communication with the therapy device handle 34 ( FIG. 5 ), thereby permitting the position of the therapy catheter 30 to be manipulated without using a guidewire.
- the positioning balloon 252 can be used to hold the therapy device steady once in position.
- FIGS. 9-10 show various illustrations of the present invention prior to use.
- a first needle receiving port 86 A may be positioned within or proximate to the suction lumen 56 co-aligned with and opposing the first needle port 58 A.
- a second needle receiving port 86 B may be positioned within or proximate to the suction lumen 56 co-aligned with and opposing the second needle port 58 B.
- the first needle receiving port 86 A is in communication with the first suture lumen 76 and contains at least a first needle catch 88 A attached to the first suture 78 therein.
- the second needle receiving port 86 B is positioned proximate to the suction recess 56 opposing the second needle port 58 B.
- the second needle receiving port 86 B is in communication with the second suture lumen 80 and contains a second needle catch 88 B attached to the second suture 82 therein.
- FIGS. 11-12 show an embodiment of the therapy catheter of the present invention during various stages of use.
- forward movement of the first actuator 44 within the first actuator recess 46 results in the first needle 70 advancing through the first needle port 58 A and traversing the suction recess 56 .
- Continued actuation of the first actuator 44 results in the first needle 70 advancing through the first needle receiving port 86 A and engaging the first needle catch 88 A positioned within the first suture lumen 76 .
- the first needle catch 88 A engages and is retained on the first needle 70 .
- the user may then retract the first needle 70 , thereby pulling the first suture across the suture recess 56 .
- the user rearwardly moves the first actuator 44 .
- the first needle 70 having the first needle catch 88 A attached thereto is retracted through the first needle receiving port 86 A, traverses the suction recess 56 , and enters the first needle lumen 68 through the first needle port 58 A.
- FIG. 12 shows the first suture 78 traversing the suction recess 56 .
- forward movement of the second actuator 48 results in the second needle 74 advancing through exiting the second needle port 58 B and traversing the suction recess 56 .
- the continued actuation of the second actuator 48 results in the second needle 74 advancing through the second needle receiving port 86 B and engaging the second needle catch 88 B positioned within the second suture lumen 80 .
- the second needle catch 88 B is then engaged and retained on the second needle 74 .
- the user may retract the second needle 74 thereby pulling the second suture across suture recess second needle port 58 B.
- the user rearwardly moves the second actuator 48 . As shown in FIG.
- the second needle 74 having the second needle catch 88 B attached thereto is retracted through the second needle receiving port 86 B, traverses the suction recess 56 , and enters the second needle lumen 72 through the second needle port 58 B.
- the second suture 82 which is attached to the second needle catch 88 B, thus traverses the suction recess 56 .
- FIG. 15 illustrates an alternate embodiment of the present invention.
- the elongated body 32 includes a suction recess 90 formed thereon which is in fluid communication with a suction lumen 92 formed therein which in turn is in communication with a vacuum source (not shown) attached to the suction connector 40 ( FIG. 6 ).
- First and second needle ports 94 A, 94 B, respectively, are positioned within or proximate to the suction recess 90 .
- first and second needle receiving ports 96 A, 96 B respectively, are positioned within or proximate to the suction recess 90 and are co-aligned with and opposed to the first and second needle ports 94 A, 94 B.
- the first needle port 94 A communicates with a first needle lumen 98 .
- a first deployment rod 100 having a first detachable needle 102 attached thereto is located within the first needle lumen 98 .
- the first detachable needle 102 is coupled to a first suture 104 located within the first needle lumen 98 .
- the second needle port 94 B communicates with a second needle lumen 106 .
- a second deployment rod 108 having a second detachable needle 110 attached thereto is located within the second needle lumen 106 .
- the second detachable needle 110 is coupled to a second suture 112 located within the second needle lumen 106 .
- the first needle receiving port 96 A leads to a first needle trap lumen 114 A formed in or positioned proximate to suction recess 90 .
- a first needle trap 116 A capable of receiving and retaining the first detachable needle 102 therein is positioned within the first needle trap lumen 114 A.
- the second needle receiving port 96 B leads to a second needle trap lumen 114 B formed in or positioned proximate to the suction recess 90 .
- a second needle trap 116 B capable of receiving and retaining the second detachable needle 110 therein is positioned within the second needle trap lumen 114 B.
- FIGS. 16-18 show the embodiment of FIG. 15 during use.
- Forward movement of the first actuator 44 results in first needle rod 100 extending from first needle lumen 98 .
- FIG. 17 shows the first needle rod 100 with a first detachable needle 102 attached thereto extended through the first needle port 94 A traversing the suction recess 90 , and entering into the first needle trap lumen 114 A through the first needle receiving port 96 A.
- the first detachable needle then engages the first needle trap 116 A.
- the first needle rod 100 is retracted into the first needle lumen 98 , thereby leaving first detachable needle 102 in first needle trap 116 A.
- FIG. 18 shows the first needle rod 100 retracted into the first needle lumen 98 .
- the first suture 104 which is attached to the first detachable needle 102 traverses the suction recess 90 .
- a second needle (not shown) may be deployed in a similar manner.
- FIGS. 19-21 show various illustrations of the fastener catheter of the present invention.
- the fastener catheter 130 comprises a fastener catheter body 132 having a fastener catheter handle 134 attached at the proximal end and a fastening tip 136 at the distal end.
- the fastener catheter 130 may be manufactured in a variety of shapes, sizes, lengths, widths, and biologically-compatible materials as desired.
- FIG. 20 shows a more detailed illustration of a preferred fastener catheter handle 134 of the present invention.
- the fastener catheter handle 134 comprises a fastener handle body 138 having an auxiliary connector 140 and a fastener body receiver 142 attached thereto.
- the auxiliary connector 140 may be capable of coupling to a variety of devices including, for example, a vacuum source or a visualization device.
- the fastener body connector 142 is capable of receiving and coupling to the fastener catheter body 132 ( FIG. 19 ).
- a fastener actuator 144 may be positioned within a fastener actuator recess 146 formed on the fastener handle body 138 .
- the fastener actuator 144 positioned within the fastener actuator recess 146 may be capable of being positioned in three distinct locations. For example, in a non-actuated condition, the fastener actuator 144 may be located in a first position 148 . Thereafter, the user may partially actuate the fastener catheter 130 by positioning the fastener actuator 144 in a second position 150 , thereby deploying a fastening device (not shown) from the fastener catheter 130 ( FIG. 19 ).
- the user may then fully actuate the fastener catheter 130 by moving the fastener actuator 144 to a third position 152 within the fastener actuator recess 146 , thereby actuating a cutting member (discussed below) located on or proximate to the fastening tip 136 .
- FIGS. 21 a and 21 b illustrate, in exploded fashion, pieces of fastening tip 136 .
- An inner body 154 includes a suture recess 160 formed in the side thereof, which in turn is in communication with an internal fastener lumen 158 .
- Inner body 154 also includes a pin 162 extending radially outward therefrom.
- Sleeve 156 comprises an axial deployment lumen 166 of sufficient diameter to receive inner body 154 therein.
- Sleeve 156 also comprises a cutting recess 168 formed in an axial side thereof and a cutting member 170 on a proximal edge of cutting recess 168 .
- Slot 172 extends parallel to the axis of the deployment lumen 166 and may extend radially through to fastener lumen. Pin recess 172 receives pin 162 in sliding relation.
- FIGS. 23-24 illustrate fastener 180 of the present invention.
- Fastener 180 may be manufactured from a variety of materials including, for example, Nickel-Titanium alloys, shape-memory alloys, stainless steel, titanium, various plastics, and other biologically-compatible materials.
- Fastener 180 has an internal lumen 188 extending axially therethrough and one or more engagement member(s) 184 formed on an end thereof. Between the engagement members is defined engagement aperture 186 which is in communication with attachment lumen 188 .
- Attachment lumen 188 and engagement aperture 186 are sized to receive a first suture lead 176 A and a second suture lead 176 B therein.
- engagement member(s) 184 Prior to deployment, engagement member(s) 184 are deflected radially away from the axis of the fastener 180 such that engagement aperture 186 has a relative large first diameter sufficient to permit suture leads 176 A and 176 B to slide therethrough.
- engagement members 184 Upon deployment, i.e. after the suture leads 176 A and 176 B have been retracted, engagement members 184 are deflected or permitted to spring back toward the axis of the device such that the engagement aperture 186 assumes a second smaller diameter compressing and securing suture leads 176 A and 176 B in place.
- the engagement member(s) 184 tend to spring toward a natural position at the axis of fastener 180 .
- Each engagement member(s) 184 may further include a pointed tip 190 which, when the engagement member(s) are in the deployed position, engages and further restricts movement of the suture leads 176 A, 176 B.
- FIG. 22 An operational fastening tip 136 with fastener 180 attached thereto and ready for deployment can be seen in FIG. 22 .
- Inner body 154 has been placed inside sleeve 156 such that suture recess 160 is in alignment with cutting recess 168 .
- Pin 172 is in slidable communication with slot 162 thereby permitting relative linear motion, but preventing relative rotational motion, between inner body 154 and sleeve 156 .
- Fastener 180 has been placed on the end of the fastening tip 136 by deflecting the engagement members 184 radially outward until they can be placed around the outer circumference of the inner body 154 .
- the fastener is secured to the end of inner body 154 by means of the frictional engagement between the engagement members 184 and the outer surface of inner body 154 .
- Suture loop 178 extends from the fastener 180 .
- Suture leads 176 A and 176 B extend through the lumen 188 , through engagement aperture 186 , exit the side of inner body 154 through suture recess 160 , and exit the side of sleeve 156 through cutting recess 168 .
- Deployment of the fastener is a two step process. Once suture 178 has been secured through one or more tissue segments, the fastener tip 136 is coaxed toward the tissue and the suture leads 176 A and 176 B are pulled away from the tissue until the suture loop is sufficiently cinched around the target tissue. Sleeve 156 is then held in place adjacent the tissue while the inner body 154 is pulled axially away. This causes sleeve 156 to push (i.e. slide) fastener 180 off the outer surface of the inner body 154 . When fastener 180 has been completely removed from inner body 154 engagement members 184 spring axially inward thereby reducing the diameter of engagement aperture 186 and securing suture leads 176 A and 176 B.
- the second deployment step, cutting suture leads 176 A and 176 B, is accomplished when the inner body 154 is pulled sufficiently through sleeve 156 that the suture leads are pinched between the trailing edge of suture recess 160 and cutting member 170 and ultimately cut by cutting member 170 .
- Remote deployment of fastener 180 is accomplished by attaching inner body 154 to fastener actuator 144 , and attaching sleeve 156 to the fastener catheter handle 134 .
- axial movement of the fastener actuator 144 relative to the handle 134 causes similar relative movement between inner body 154 and sleeve 156 .
- the distal end of inner body 154 will extend from sleeve 156 a sufficient distance to hold fastener 180 thereon.
- the inner body 154 In the second position 150 the inner body 154 will have been withdrawn into sleeve 156 a sufficient distance to deploy the fastener 180 , and in the third position 152 the inner body 154 will have been withdrawn a sufficient distance to cut the suture leads 176 A and 176 B.
- the present invention also discloses various methods of using the disclose mitral valve repair system to repair discreet tissue portions in vivo.
- the following paragraphs describe methods of repairing a dysfunctional mitral valve, though those skilled in the art will appreciate that the present invention and procedure may be adapted for use on other valves or in other procedures requiring the attachment of two or more pieces of tissue.
- a guidewire capable of traversing the circulatory system and entering the heart of the patient is introduced into the patient through an endoluminal entry point.
- the endoluminal entry point may be formed in a femoral vein or right jugular vein.
- the guidewire is advanced through the circulatory system, eventually arriving at the heart.
- the guidewire is directed into the right atrium, traverses the right atrium and is made to puncture with the aid of a tran-septal needle or pre-existing hole, the atrial septum, thereby entering the left atrium.
- the guidewire 220 may then be advanced through the mitral valve 222 and into the left ventricle 226 .
- the guidewire 220 traverses the aortic valve 228 into the aorta 230 and is made to emerge at the left femoral artery through an endoluminal exit point. Once the guidewire 220 is positioned, the endoluminal entry or exit port is dilated to permit entry of a catheter therethrough. A protective sheath may be advanced in the venous area to protect the vascular structure.
- the guide catheter 10 of the present invention may be attached to the guidewire 220 and advanced through the dilated guidewire entry port to a point proximate to the mitral valve 222 .
- the mitral valve repair system of the present invention may approach the mitral valve from an antegrade position or from a retrograde position as desired by the user.
- the therapy catheter 30 may be advanced through the guide catheter 10 to a position proximate to the mitral valve 222 .
- FIG. 27 shows the therapy catheter 30 emerging from the guide catheter 10 proximate to the mitral valve 222 .
- the user may actuate the suction actuator 52 located on the handle body 38 of the therapy device handle 34 ( FIG. 6 ).
- a suction force is applied from the suction recess 56 formed on the suture attachment tip 36 of the therapy catheter 30 ( FIG. 7 ) to the tissue located proximate thereto.
- a first valve leaflet 240 A is engaged and retained by the suction force applied through the suction recess 56 .
- the user may apply a suture 242 A thereto as described above.
- FIG. 29 shows the first valve leaflet 240 A having a first suture 242 A applied thereto.
- the therapy catheter 30 may then be rotated and positioned to engage a second valve leaflet 240 B.
- the user may actuate the suction actuator 52 to apply suction force to the second valve leaflet 240 B through the suction recess 56 .
- the user may apply a suture 242 B thereto by actuating the second actuator 48 located on the therapy device handle 34 , which results in the second needle 74 advancing through the second valve leaflet 240 B and engaging and retaining the second needle catch 88 B, thereby applying a second suture 242 B to the tissue.
- the second actuator 48 located on the therapy device handle 34
- first and second sutures 242 A, 242 B are actually portions of the same suture such that when the therapy catheter is removed there is a single suture loop through the valve leaflets 240 A and 240 B.
- the fastener catheter 130 may be attached to the guidewire 220 and will be attached to first and second sutures 242 A, 242 B. Thereafter, the fastener catheter 130 may be inserted into the guide catheter 10 and advanced to a position proximate to the mitral valve 222 . The user then draws the first and second sutures 242 A, 242 B taut while advancing the fastener catheter 130 to the mitral valve 22 , thereby decreasing the distance between the first and second valve leaflets 240 A, 240 B.
- the fastener actuator 144 causes the cutting member 170 to engage and cut the first and second sutures 242 A, 242 B.
- the fastener 180 remains applied to the mitral valve 222 .
- FIGS. 35-44 describe an alternate method of repairing tissue, specifically valve leaflets in this embodiment, in vivo.
- a guide catheter 10 is advanced through the circulatory system to the right atrium of the heart.
- a dilator 250 is advanced through the guide catheter 10 and is made to puncture the atrial septum, thereby entering the left atrium.
- the guide catheter 10 is advanced into the left atrium through the punctured atrial septum and positioned proximate to the mitral valve 222 .
- the therapy catheter 30 may be inserted into the guide catheter 10 and advanced to a position proximate to the mitral valve 222 .
- FIG. 35-37 a guide catheter 10 is advanced through the circulatory system to the right atrium of the heart.
- a dilator 250 is advanced through the guide catheter 10 and is made to puncture the atrial septum, thereby entering the left atrium.
- the guide catheter 10 is advanced into the left atrium through the punctured atrial septum and positioned proximate to the
- an inflatable positioning balloon 252 (discussed above) located on the therapy catheter 30 is inflated to orient and steady the catheter.
- the suction actuator 52 on the therapy device handle 34 is then actuated to apply a suction force to the suction recess 56 (see. FIG. 6 ).
- the inflated balloon 252 engages the second valve leaflet 240 B which forces the suction recess 56 towards the first valve leaflet 240 A, thereby resulting in the stabilization of the first valve leaflet 240 A as shown in FIG. 40 .
- the user may then apply the first suture 242 A to the first valve leaflet 240 A as described above.
- the user may deflate the inflatable positioning balloon 252 and rotates the therapy catheter 30 approximately 180°. Thereafter, the user inflates the positioning balloon 252 and actuates suction actuator 52 to apply a suction force to the suction recess 56 . As shown in FIG. 42 , the inflatable positioning balloon 252 is again inflated and made to engage the first valve leaflet 240 thereby forcing the suction recess 56 to engage the second valve leaflet 240 B and permitting the stabilization of the second valve leaflet 240 B as shown in FIG. 42 . Thereafter, the user applies the second suture 242 B to the second valve leaflet 240 B as described above. FIGS.
- 43-44 show the first and second valve leaflets 240 A, 240 B having a first and second suture 242 A, 242 B applied thereto. Thereafter, the therapy catheter 30 is removed from the patient's body and the fastener catheter 130 is used to apply a fastener to the first and second sutures 242 A, 242 B as described above.
Abstract
The present invention is directed to various systems for repairing tissue within the heart of a patient. The mitral valve repair system of the present invention comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying a suture to the tissue, and a fastener catheter capable of attaching a fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. In addition, the present invention discloses various methods for repairing tissue within the heart of a patient. In one embodiment, the method of repairing heart valve tissue includes advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with the therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and joining the first and second leaflets by reducing the distance between the first and second sutures.
Description
- This application is a divisional of U.S. application Ser. No. 10/389,721 filed on Mar. 14, 2003, the contents of which are expressly incorporated herein by reference in their entirety.
- In vertebrate animals, the heart is a hollow muscular organ having four pumping chambers: the left atrium, the left ventricle, the right atrium and the right ventricle. The atria are isolated from their respective ventricles by one-way valves located at the respective atrial-ventricular junctions. These valves are identified as the mitral (or bicuspid) valve on the left side of the heart, and tricuspid valve on the right side of the heart. The exit valves from the left and right ventricles are identified as the aortic and pulmonary valves, respectively.
- The valves of the heart are positioned in valvular annuluses that comprise dense fibrous rings attached either directly or indirectly to the atrial and ventricular muscle fibers. Valve leaflets comprising flexible collagenous structures are attached to, and extend inwardly from, the annuluses to meet at coapting edges. The aortic, tricuspid and pulmonary valves each have three leaflets, while the mitral valve only has two. In normal operation, the leaflets of the mitral valve open as left ventricle dilates thereby permitting blood to flow from the left atrium into the left ventricle. The leaflets then coapt (i.e. close) during the contraction cycle of the left ventricle, thereby preventing the blood from returning to the left atrium and forcing the blood to exit the left ventricle through the aortic valve. Similarly, the tricuspid valve regulates flow from the right atrium into the right ventricle, and the pulmonary valve regulates blood exiting the right ventricle.
- For a number of clinical reasons various problems with heart valves can develop. One common form of heart disease involves the deterioration or degradation of the heart valves which leads to stenosis and/or insufficiency. Heart valve stenosis is a condition in which the valve does not open properly. Insufficiency is a condition in which the valve does not close properly. Insufficiency of the mitral valve, most common because of the relatively high fluid pressures in the left ventricle, results in mitral valve regurgitation (“MR”), a condition in which blood reverses its intended course and flows “backward” from the left ventricle to the left atrium during ventricular contractions.
- A number of surgical techniques have been developed to repair degraded or otherwise incompetent heart valves. A common procedure involves replacement of a native aortic or mitral valve with a prosthetic heart valve. These procedures require the surgeon to gain access to the heart through the patient's chest (or possibly percutaneously), surgically remove the incompetent native heart valve and associated tissue, remodel the surrounding valve annulus, and secure a replacement valve in the remodeled annulus. While such procedures can be very effective, there are shortcomings associated with such replacement valves. For example, the invasive nature of the implantation procedure typically results in substantial patient discomfort and requires patients to remain hospitalized for extended recovery periods. In addition, the two basic types of commercially available replacement valves, mechanical valves and tissue valves, each have shortcomings of their own. Mechanical replacement valves typically offer extended operational lifetimes, but the patient is usually required to maintain a regimen of anti-coagulant drugs for the remainder of his or her life. Tissue valves typically offer a higher degree of acceptance by the body which reduces or eliminates the need for anti-coagulants. However, the operational lifetimes of tissue valves is typically shorter than mechanical valves and thus may require a subsequent replacement(s) during the patient's lifetime.
- As an alternative to prosthetic heart valve replacement, it is often preferable to remodel the native heart valve and/or the surrounding tissue. Remodeling of the valve often preserves left ventricular function better than mitral valve replacement because the subvalvular papillary muscles and chordae tendineae are preserved (most prosthetic valves do not utilize these muscles). Valvular remodeling can be accomplished by implanting a prosthetic ring (a.k.a. “annuloplasty ring”) into the valve annulus to reduce and/or stabilize the structure of the annulus in order to correct valvular insufficiency. Annuloplasty rings are typically constructed of a resilient core covered with a fabric sewing material. Annuloplasty procedures can be performed alone, or they can be performed in conjunction with other procedures such as leaflet repair. Although such annuloplasty procedures have become popular and well accepted, reshaping the surrounding annulus and traditional leaflet repairs do not always lead to optimum leaflet coaptation. As a result, some patients may still experience residual mitral valve regurgitation following such annuloplasty procedures.
- A recently developed technique known as a “bow-tie” repair has also been advocated for repairing insufficient heart valves, in particular the mitral valve. The mitral valve bow-tie technique involves suturing the anterior and posterior leaflets together near the middle of their coapting edges, thereby causing blood to flow through two newly formed openings. While this does reduce the volume of blood that can flow from the atrium to the ventricle, this loss is compensated by improved leaflet coaptation which reduces mitral regurgitation. This process as originally developed by Dr. Ottavio Alfieri involved arresting the heart and placing the patient on extracorporeal bypass and required invasive surgery to access and suture the leaflets together. More recently, however, some have advocated a “beating heart” procedure in which the heart is accessed remotely and remains active throughout the bow-tie procedure.
- One particular method for performing a beating heart bow-tie procedure (i.e. without extracorporeal bypass) has been proposed by Dr. Mehmet Oz, of Columbia University. (See PCT publication WO 99/00059, published Jan. 7, 1999, the contents of which are incorporated herein by reference). In one embodiment of this procedure, the associated device consists of a forceps-like grasper used to grasp and hold the mitral valve leaflets in a coapted position prior to the connecting step. Since the mitral valve leaflets curve toward and slightly into the left ventricular cavity at their mating edges, the grasper device is passed through a sealed aperture in the apex of the left ventricle. The edges of the mating mitral valve leaflets are then grasped and held together, and subsequently a fastening device such as a clip or suture is utilized to fasten them. The Mehmet Oz disclosure also discloses teeth on the grasper device that are linearly slidable with respect to one another so as to permit alignment of the mitral valve leaflets prior to fastening. Since the procedure is done on a beating heart, it will be readily understood that the pressures and motions within the left ventricle and mitral valve leaflets are severe and render Dr. Oz's procedure very skill-intensive.
- The bow-tie technique has proved to be a viable alternative for treating otherwise incompetent heart valves. Nonetheless, shortcomings associated with the current bow-tie procedures have been identified. Current systems typically include tissue stabilizing devices having mechanical graspers, barbed members, and vacuum devices. Often, use of these devices results in the less than optimal leaflet stabilization and fastener placement. Many of these problems arise from the fact that the surgeon is required to capture, retain and fasten the leaflets in one relatively inflexible procedure. These difficulties are compounded when the leaflets are small or calcified making them difficult to pull together, and in beating heart procedures in which the leaflets are actively functioning. In addition, the size and complexity of most current devices make minimally invasive surgical procedures more difficult, if not impossible. In light of the foregoing, there is presently a need for improved systems for stabilizing multiple tissue heart valve leaflets and placing a fastening device therebetween. More specifically, there is a present need for an improved bow-tie procedure for repairing a patient's mitral valve.
- The present invention solves the problem of effectively stabilizing at least one tissue portion in vivo. Additionally, the present invention provides a device capable of delivering a fastener to the stabilized tissue portion through a catheter from a remote insertion location.
- In one aspect, the present invention is directed to a system for repairing tissue within the heart of a patient and includes a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying at least one suture to the tissue, and a fastener catheter capable of attaching at least one fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter.
- In another aspect, the present invention pertains to a system for repairing tissue within the heart of a patient and comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter having at least one needle lumen in communication with at least one needle port positioned therein, at least one needle positioned within the needle lumen, and a fastener catheter having at least one fastener detachably coupled thereto. In addition, the fastener catheter includes at least one cutting member.
- In yet another aspect, the present invention discloses a system for repairing tissue within the heart of a patient and includes a guide wire capable of being inserted into the patient and advanced through a circulatory pathway, a therapy catheter attachable to the guide wire and capable of applying at least one suture to the tissue, and a fastener catheter attachable to the guide wire and capable of attaching at least one fastener to the suture.
- In a further aspect, the present invention pertains to a guide catheter for delivering a tissue repair device to tissue located within the heart of a patient and comprises an outer wall defining an outer wall lumen, a directing lumen capable of receiving a steering device therein and a flexible support device positioned within the outer wall lumen.
- In another aspect, the present invention discloses a catheter for delivering a suture to tissue within the heart of a patient and includes an elongated body having a distal end, at least one suction recess formed on the distal end, at least one needle port located proximate to the suction recess, at least one needle lumen having at least one needle positioned therein in communication with the needle port, at least one needle receiving port having at least one needle catch located therein positioned proximate to the suction recess, and at least one actuator member in communication with the needle.
- In yet another aspect, the present invention is directed to a catheter for delivering a suture to tissue within the heart of a patient and comprises an elongated body having a distal end with at least one suction recess formed thereon, at least one needle port located proximate to the suction recess, at least one needle lumen having at least one detachable needle attached to suture material positioned therein and in communication with the needle port, at least one needle receiving port located proximate to the suction recess, at least one needle trap capable of receiving the detachable needle positioned within the needle receiving port, and at least one actuator member in communication with the needle.
- In yet another aspect, the present invention pertains to a device for applying a fastener to suture material attached to tissue within the body of a patient and includes a catheter body having a proximal end and a distal end, an inner body defining a suture recess and an actuation recess, and a movable sleeve defining a deployment lumen. The suture recess on the inner body is in communication with a fastener lumen capable of receiving a fastener therein. The actuation recess is in communication with an actuation lumen formed in the inner body. The deployment lumen formed in the movable sleeve is sized to receive the inner body therein and includes a cutting recess having a cutting member located proximate thereto.
- In another aspect, the present invention is directed to a fastener attachable to suture material and comprises a fastener body having at least one attachment lumen formed therein and at least one engagement member attached to the fastener body wherein the engagement member is capable of engaging and retaining the suture material. The engagement member defines an engagement aperture which is in communication with the attachment lumen. The attachment lumen is capable of receiving at least one suture therein.
- The present invention also discloses various methods of repairing heart valve tissue within the body of a patient. In one aspect, a method of repairing tissue within the heart of a patient is disclosed which includes advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with the therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and joining the first and second leaflets by reducing the distance between the first and second sutures.
- An alternate method of repairing tissue within the heart of a patient is disclosed and comprises advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with said therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and removing the therapy catheter from the guide catheter. Thereafter, a fastener catheter is positioned over the first and second suture and advanced through the guide catheter to the heart valve. Once positioned, the first and second leaflets are joined by reducing the distance between the first and second sutures and a fastener is deployed from the fastener catheter.
- Other objects, features, and advantages of the present invention will become apparent from a consideration of the following detailed description.
- The apparatus of the present invention will be explained in more detail by way of the accompanying drawings, wherein:
-
FIG. 1 shows a perspective view of an embodiment of the guide catheter of the present invention; -
FIG. 2 shows a cross-sectional view of an embodiment of the guide catheter of the present invention; -
FIG. 3 shows a cross-sectional view of an alternate embodiment of the guide catheter of the present invention; -
FIG. 4 shows a cross-sectional view of the embodiment of the guide catheter shown inFIG. 3 ; -
FIG. 5 shows a perspective view of an embodiment of the therapy catheter of the present invention; -
FIG. 6 shows an embodiment of the therapy device handle of the present invention; -
FIG. 7 shows an perspective view of an embodiment of the elongated body of the present invention having a suture attachment tip attached thereto; -
FIG. 8A shows a cross-sectional view of an embodiment of the elongated body of the present invention; -
FIG. 8B shows a cross sectional view of an alternate embodiment of the elongated body of the present invention; -
FIG. 8C shows a side cross-sectional view of the embodiment of the elongated body shown inFIG. 8B ; -
FIG. 9 shows a top cross-sectional view of an embodiment of the elongated body of the present invention; -
FIG. 10 shows a side cross-sectional view of the embodiment of the elongated body shown inFIG. 9 prior to actuation; -
FIG. 11 shows a side cross-sectional view of an embodiment of the elongated body shown inFIG. 10 during actuation; -
FIG. 12 shows a side cross-sectional view of an embodiment of the elongated body shown inFIG. 10 following actuation; -
FIG. 13 shows another side cross-sectional view of an embodiment of the elongated body shown inFIG. 10 during actuation; -
FIG. 14 shows another side cross-sectional view of an embodiment of the elongated body shown inFIG. 10 following actuation; -
FIG. 15 shows a top cross-sectional view of an alternate embodiment of the elongated body of the present invention; -
FIG. 16 shows a side cross-sectional view of the embodiment of the elongated body shown inFIG. 15 prior to actuation; -
FIG. 17 shows a side cross-sectional view of an embodiment of the elongated body shown inFIG. 15 during actuation; -
FIG. 18 shows a side cross-sectional view of an embodiment of the elongated body shown inFIG. 15 following actuation; -
FIG. 19 shows a perspective view of an embodiment of the fastener catheter of the present invention; -
FIG. 20 shows an embodiment of the fastener catheter handle of the present invention; -
FIGS. 21 a and 21 b show a perspective view of the components of the fastener tip of the present invention; -
FIG. 22 shows a perspective view of the fastener tip of the present invention having a fastener attached thereto; -
FIG. 23 shows a side view of an embodiment of the fastener of the present invention; -
FIG. 24 shows a side view of the fastener of the present invention attached to suture material; -
FIG. 25 shows a perspective view of a guidewire traversing the mitral valve within a heart; -
FIG. 26 shows a perspective view of a guide catheter positioned proximate to the mitral valve within a heart; -
FIG. 27 shows a perspective view of a therapy catheter advancing through a guide catheter to a position proximate to the mitral valve of a heart; -
FIG. 28 shows a perspective view of a therapy catheter stabilizing a first leaflet of the mitral valve of a heart; -
FIG. 29 shows a perspective view of the first leaflet of the mitral valve having a suture applied thereto; -
FIG. 30 shows a perspective view of a therapy catheter stabilizing a second leaflet of the mitral valve of a heart; -
FIG. 31 shows a perspective view of the first and second leaflets of the mitral valve having sutures applied thereto; -
FIG. 32 shows a perspective view of a fastener catheter advancing through a guide catheter to a position proximate to the mitral valve of a heart; -
FIG. 33 shows a perspective view of the fastener catheter of the present invention applying a fastener to suture material attached to the mitral valve; -
FIG. 34 shows a perspective view of the fastener applied to suture material attached to the first and second leaflet of the mitral valve; -
FIG. 35 shows a perspective view of another embodiment of the present invention wherein a dilator is used to introduce the guide catheter onto the left atrium; -
FIG. 36 shows a perspective view of the dilator of the present embodiment traversing the atrial septum; -
FIG. 37 shows a perspective view of the guide catheter of the present embodiment positioned within the left atrium proximate to the mitral valve; -
FIG. 38 shows a perspective view of an alternate embodiment of the therapy catheter advanced through the guide catheter to the mitral valve; -
FIG. 39 shows a perspective view of the embodiment of the therapy catheter shown inFIG. 38 having an inflatable positioning balloon positioned thereon inflated; -
FIG. 40 shows a perspective view of the embodiment of the therapy catheter shown inFIG. 38 engaging a first leaflet; -
FIG. 41 shows a perspective view of the first leaflet of the mitral valve having a suture attached thereto; -
FIG. 42 shows a perspective view of the embodiment of the therapy catheter shown inFIG. 38 engaging the second leaflet of the mitral valve; -
FIG. 43 shows a perspective view of the first and second leaflets of the mitral valve having sutures attached thereto; and -
FIG. 44 shows another perspective view of the first and second leaflets of the mitral valve having sutures attached thereto. - Disclosed herein is a detailed description of various embodiments of the present invention. This description is not to be taken in a limiting sense, but is made merely for the purpose of illustrating the general principles of the invention. The overall organization of the detailed description is for the purpose of convenience only and is not intended to limit the present invention.
- The mitral valve repair system of the present invention is designed for use in a surgical treatment of bodily tissue. As those skilled in the art will appreciate, the exemplary mitral valve repair system disclosed herein is designed to minimize trauma to the patient before, during, and subsequent to a minimally invasive surgical procedure while providing improved tissue stabilization and enhanced placement of a fastening device thereon. The mitral valve repair system of the present invention includes a guide catheter capable of being introduced into body of a patient and advanced to an area of interest, a therapy catheter capable of traversing or otherwise engaging the guide catheter and applying a suture to a repair site, and a fastener catheter capable of applying a fastening device to the attached suture. While the guide catheter, therapy catheter, and fastener catheter cooperatively enable a surgeon to deliver a suture to a repair site in vivo, the various components of the present invention may be used individually. For example, the therapy catheter, the fastener catheter, or both may be coupled to a guidewire and advanced to a repair site in vivo without the use of the guide catheter. The mitral valve repair system of the present invention is useful in repairing dysfunctional mitral valve tissue by stabilizing discreet valvular tissue pieces and deploying a fastening device therethrough. However, the mitral valve repair system may be used to repair tissue throughout a patient's body as desired. For example, the present invention may also be used to repair arterial septal defects (ASD), ventricular septal defects (VSD), and defects associated with patent foramen ovale (PFO).
-
FIGS. 1-4 show various illustrations of the guide catheter of the present invention. As shown inFIG. 1 , theguide catheter 10 comprises aguide body 12 having aproximal end 14 and adistal end 16. Those skilled in the art will appreciate that theguide catheter 10 of the present invention may be manufactured from a variety of materials, including, without limitation, various plastics, thermoplastics, silicones, elastomers, ceramics, composite materials, or various combinations of the aforementioned materials. In addition, theguide catheter 10 may be manufactured in various lengths and widths as desired by the user.FIGS. 2-4 show various embodiments of theguide catheter 10. As shown inFIG. 2 , theguide catheter 10 includes anouter wall 18 defining at least oneinternal lumen 20.FIGS. 3-4 illustrate alternate embodiments wherein theouter wall 18 defines aninternal lumen 20 and includes at least onedirecting lumen 22 formed therein. The directinglumen 22 is sized to receive a guidewire (not shown) or steering device (not shown) therein. In another embodiment, at least one flexible support structure such as a coiled wire support (not shown) may be embedded within theouter wall 18 of theguide catheter 10. -
FIG. 5 shows a perspective view of an embodiment of thetherapy catheter 30 of the present invention. As shown inFIG. 5 , thetherapy catheter 30 includes anelongated body 32 having a therapy device handle 34 located at the proximal end and asuture attachment tip 36 located at the distal end. Like theguide body 12 of theguide catheter 10, theelongated body 32 may be manufactured in a variety of shape, sizes, lengths, widths, and biologically-compatible materials as desired. -
FIG. 6 shows a more detailed illustration of the therapy device handle 34 of the present invention. As shown, the therapy device handle 34 comprises ahandle body 38 having at least asuction connector 40 and aelongated body receiver 42 attached thereto. Thesuction connector 40 is capable of coupling to a vacuum source (not shown). Theelongated body receiver 42 is capable of receiving the elongated body 32 (FIG. 5 ) thereon. Afirst actuator 44 is located within afirst actuator recess 46 formed on thehandle body 38. Similarly, asecond actuator 48 is positioned within asecond actuator recess 50 formed in thehandle body 38. As shown inFIG. 6 , asuction actuator 52, configured to open or close the fluid path betweensuction connector 40 andelongated body receiver 42, may be located within asuction actuator recess 54 proximal to the first andsecond actuators -
FIGS. 7-10 show various illustrations of theelongated body 32 and thesuture attachment tip 36 of the present invention. As shown inFIG. 7 , theelongated body 32 includes asuction recess 56 having afirst needle port 58A and asecond needle port 58B located proximate thereto. Theelongated body 32 or thesuture attachment tip 36 may include aguidewire port 60 capable of receiving aguidewire 62.FIG. 8A shows a cross sectional view of theelongated body 32. As shown, theelongated body 32 comprises anouter wall 64 defining asuction lumen 66. Thesuction lumen 66 is in fluid communication with the suction recess 56 (FIG. 7 ) and the vacuum source (not shown) attached to thesuction connector 40 located on the therapy device handle 34 (FIG. 6 ). Afirst needle lumen 68 having afirst needle 70 located therein may be formed in or otherwise positioned proximate to theouter wall 64 of theelongated body 32. Similarly, asecond needle lumen 72 having asecond needle 74 located therein may be formed in or otherwise positioned proximate to theouter wall 64 of theelongated body 32. The first andsecond needles second actuators FIG. 6 ). The forward and rearward movement of the first andsecond actuators second needles second needle lumens second needles first suture lumen 76 having afirst suture 78 located therein and asecond suture lumen 80 having asecond suture 82 located therein may be formed within or located proximate to theouter wall 64 of theelongated body 32. Of course one of skill in the art will recognize that references herein to “sutures” include not just traditional suture material, but also any material of sufficient length and flexibility to accomplish the purposes of this tissue repair system. In one embodiment, aguidewire lumen 84 sized to receiveguidewire 62 therein may be positioned within or proximate to theouter wall 64 of theelongated body 32 and may be in communication with theguidewire port 60 formed on thesuture attachment tip 36. -
FIGS. 8B-8C show various illustrations of an alternate embodiment of the present invention, wherein aninflatable positioning balloon 252 is positioned on theouter wall 64 of theelongated body 32. As shown, theinflatable positioning balloon 252 is in fluid communication with aninflation lumen 84′ positioned within theelongated body 32. Theinflation lumen 84′ may be in fluid communication with an inflation source in ways known to those skilled in the art and may be attached to or otherwise in communication with the therapy device handle 34 (FIG. 5 ), thereby permitting the position of thetherapy catheter 30 to be manipulated without using a guidewire. Moreover, thepositioning balloon 252 can be used to hold the therapy device steady once in position. -
FIGS. 9-10 show various illustrations of the present invention prior to use. As shown, a firstneedle receiving port 86A may be positioned within or proximate to thesuction lumen 56 co-aligned with and opposing thefirst needle port 58A. Similarly, a secondneedle receiving port 86B may be positioned within or proximate to thesuction lumen 56 co-aligned with and opposing thesecond needle port 58B. The firstneedle receiving port 86A is in communication with thefirst suture lumen 76 and contains at least afirst needle catch 88A attached to thefirst suture 78 therein. Likewise, the secondneedle receiving port 86B is positioned proximate to thesuction recess 56 opposing thesecond needle port 58B. The secondneedle receiving port 86B is in communication with thesecond suture lumen 80 and contains asecond needle catch 88B attached to thesecond suture 82 therein. -
FIGS. 11-12 show an embodiment of the therapy catheter of the present invention during various stages of use. As shown inFIG. 11 , forward movement of thefirst actuator 44 within the first actuator recess 46 (FIG. 6 ) results in thefirst needle 70 advancing through thefirst needle port 58A and traversing thesuction recess 56. Continued actuation of thefirst actuator 44 results in thefirst needle 70 advancing through the firstneedle receiving port 86A and engaging thefirst needle catch 88A positioned within thefirst suture lumen 76. Thefirst needle catch 88A engages and is retained on thefirst needle 70. The user may then retract thefirst needle 70, thereby pulling the first suture across thesuture recess 56. To retract thefirst needle 70, the user rearwardly moves thefirst actuator 44. As shown inFIG. 12 , thefirst needle 70 having thefirst needle catch 88A attached thereto is retracted through the firstneedle receiving port 86A, traverses thesuction recess 56, and enters thefirst needle lumen 68 through thefirst needle port 58A.FIG. 12 shows thefirst suture 78 traversing thesuction recess 56. - Similarly, as shown in
FIG. 13 , forward movement of the second actuator 48 (FIG. 6 ) results in thesecond needle 74 advancing through exiting thesecond needle port 58B and traversing thesuction recess 56. Like the actuation process described above, the continued actuation of thesecond actuator 48 results in thesecond needle 74 advancing through the secondneedle receiving port 86B and engaging thesecond needle catch 88B positioned within thesecond suture lumen 80. Thesecond needle catch 88B is then engaged and retained on thesecond needle 74. Thereafter, the user may retract thesecond needle 74 thereby pulling the second suture across suture recesssecond needle port 58B. To retract thesecond needle 74, the user rearwardly moves thesecond actuator 48. As shown inFIG. 14 , thesecond needle 74 having thesecond needle catch 88B attached thereto is retracted through the secondneedle receiving port 86B, traverses thesuction recess 56, and enters thesecond needle lumen 72 through thesecond needle port 58B. Thesecond suture 82, which is attached to thesecond needle catch 88B, thus traverses thesuction recess 56. -
FIG. 15 illustrates an alternate embodiment of the present invention. As shown, theelongated body 32 includes asuction recess 90 formed thereon which is in fluid communication with asuction lumen 92 formed therein which in turn is in communication with a vacuum source (not shown) attached to the suction connector 40 (FIG. 6 ). First andsecond needle ports suction recess 90. Similarly, first and secondneedle receiving ports 96A, 96B, respectively, are positioned within or proximate to thesuction recess 90 and are co-aligned with and opposed to the first andsecond needle ports first needle port 94A communicates with afirst needle lumen 98. Afirst deployment rod 100 having a firstdetachable needle 102 attached thereto is located within thefirst needle lumen 98. The firstdetachable needle 102 is coupled to afirst suture 104 located within thefirst needle lumen 98. Similarly, thesecond needle port 94B communicates with asecond needle lumen 106. Asecond deployment rod 108 having a seconddetachable needle 110 attached thereto is located within thesecond needle lumen 106. The seconddetachable needle 110 is coupled to asecond suture 112 located within thesecond needle lumen 106. The firstneedle receiving port 96A leads to a firstneedle trap lumen 114A formed in or positioned proximate tosuction recess 90. Afirst needle trap 116A capable of receiving and retaining the firstdetachable needle 102 therein is positioned within the firstneedle trap lumen 114A. Similarly, the second needle receiving port 96B leads to a secondneedle trap lumen 114B formed in or positioned proximate to thesuction recess 90. Like thefirst needle trap 116A, asecond needle trap 116B capable of receiving and retaining the seconddetachable needle 110 therein is positioned within the secondneedle trap lumen 114B. -
FIGS. 16-18 show the embodiment ofFIG. 15 during use. Forward movement of thefirst actuator 44 results infirst needle rod 100 extending fromfirst needle lumen 98.FIG. 17 shows thefirst needle rod 100 with a firstdetachable needle 102 attached thereto extended through thefirst needle port 94A traversing thesuction recess 90, and entering into the firstneedle trap lumen 114A through the firstneedle receiving port 96A. The first detachable needle then engages thefirst needle trap 116A. Thereafter, thefirst needle rod 100 is retracted into thefirst needle lumen 98, thereby leaving firstdetachable needle 102 infirst needle trap 116A. To retract thefirst needle rod 100, the user moves the first actuator 44 a rearward direction which causes thefirst needle rod 100 to retract into thefirst needle lumen 98.FIG. 18 shows thefirst needle rod 100 retracted into thefirst needle lumen 98. As a result, thefirst suture 104 which is attached to the firstdetachable needle 102 traverses thesuction recess 90. Those skilled in the art will appreciate that a second needle (not shown) may be deployed in a similar manner. -
FIGS. 19-21 show various illustrations of the fastener catheter of the present invention. As shown inFIG. 19 , thefastener catheter 130 comprises afastener catheter body 132 having a fastener catheter handle 134 attached at the proximal end and afastening tip 136 at the distal end. Thefastener catheter 130 may be manufactured in a variety of shapes, sizes, lengths, widths, and biologically-compatible materials as desired. -
FIG. 20 shows a more detailed illustration of a preferred fastener catheter handle 134 of the present invention. As shown, the fastener catheter handle 134 comprises afastener handle body 138 having anauxiliary connector 140 and afastener body receiver 142 attached thereto. Theauxiliary connector 140 may be capable of coupling to a variety of devices including, for example, a vacuum source or a visualization device. Thefastener body connector 142 is capable of receiving and coupling to the fastener catheter body 132 (FIG. 19 ). Afastener actuator 144 may be positioned within afastener actuator recess 146 formed on thefastener handle body 138. Thefastener actuator 144 positioned within thefastener actuator recess 146 may be capable of being positioned in three distinct locations. For example, in a non-actuated condition, thefastener actuator 144 may be located in afirst position 148. Thereafter, the user may partially actuate thefastener catheter 130 by positioning thefastener actuator 144 in asecond position 150, thereby deploying a fastening device (not shown) from the fastener catheter 130 (FIG. 19 ). The user may then fully actuate thefastener catheter 130 by moving thefastener actuator 144 to athird position 152 within thefastener actuator recess 146, thereby actuating a cutting member (discussed below) located on or proximate to thefastening tip 136. -
FIGS. 21 a and 21 b illustrate, in exploded fashion, pieces offastening tip 136. Aninner body 154 includes asuture recess 160 formed in the side thereof, which in turn is in communication with aninternal fastener lumen 158.Inner body 154 also includes apin 162 extending radially outward therefrom.Sleeve 156 comprises anaxial deployment lumen 166 of sufficient diameter to receiveinner body 154 therein.Sleeve 156 also comprises acutting recess 168 formed in an axial side thereof and a cuttingmember 170 on a proximal edge of cuttingrecess 168.Slot 172 extends parallel to the axis of thedeployment lumen 166 and may extend radially through to fastener lumen.Pin recess 172 receivespin 162 in sliding relation. -
FIGS. 23-24 illustratefastener 180 of the present invention.Fastener 180 may be manufactured from a variety of materials including, for example, Nickel-Titanium alloys, shape-memory alloys, stainless steel, titanium, various plastics, and other biologically-compatible materials.Fastener 180 has aninternal lumen 188 extending axially therethrough and one or more engagement member(s) 184 formed on an end thereof. Between the engagement members is definedengagement aperture 186 which is in communication withattachment lumen 188.Attachment lumen 188 andengagement aperture 186 are sized to receive afirst suture lead 176A and asecond suture lead 176B therein. Prior to deployment, engagement member(s) 184 are deflected radially away from the axis of thefastener 180 such thatengagement aperture 186 has a relative large first diameter sufficient to permit suture leads 176A and 176B to slide therethrough. Upon deployment, i.e. after the suture leads 176A and 176B have been retracted,engagement members 184 are deflected or permitted to spring back toward the axis of the device such that theengagement aperture 186 assumes a second smaller diameter compressing and securing suture leads 176A and 176B in place. Preferably the engagement member(s) 184 tend to spring toward a natural position at the axis offastener 180.FIG. 24 shows thefastener 180 in the deployed configuration in which asuture loop 178 has passed through twodiscreet tissue portions fastener 180. Each engagement member(s) 184 may further include apointed tip 190 which, when the engagement member(s) are in the deployed position, engages and further restricts movement of the suture leads 176A, 176B. - An
operational fastening tip 136 withfastener 180 attached thereto and ready for deployment can be seen inFIG. 22 .Inner body 154 has been placed insidesleeve 156 such thatsuture recess 160 is in alignment with cuttingrecess 168.Pin 172 is in slidable communication withslot 162 thereby permitting relative linear motion, but preventing relative rotational motion, betweeninner body 154 andsleeve 156.Fastener 180 has been placed on the end of thefastening tip 136 by deflecting theengagement members 184 radially outward until they can be placed around the outer circumference of theinner body 154. Accordingly, the fastener is secured to the end ofinner body 154 by means of the frictional engagement between theengagement members 184 and the outer surface ofinner body 154.Suture loop 178 extends from thefastener 180. Suture leads 176A and 176B extend through thelumen 188, throughengagement aperture 186, exit the side ofinner body 154 throughsuture recess 160, and exit the side ofsleeve 156 through cuttingrecess 168. - Deployment of the fastener is a two step process. Once
suture 178 has been secured through one or more tissue segments, thefastener tip 136 is coaxed toward the tissue and the suture leads 176A and 176B are pulled away from the tissue until the suture loop is sufficiently cinched around the target tissue.Sleeve 156 is then held in place adjacent the tissue while theinner body 154 is pulled axially away. This causessleeve 156 to push (i.e. slide)fastener 180 off the outer surface of theinner body 154. Whenfastener 180 has been completely removed frominner body 154engagement members 184 spring axially inward thereby reducing the diameter ofengagement aperture 186 and securing suture leads 176A and 176B. The second deployment step, cutting suture leads 176A and 176B, is accomplished when theinner body 154 is pulled sufficiently throughsleeve 156 that the suture leads are pinched between the trailing edge ofsuture recess 160 and cuttingmember 170 and ultimately cut by cuttingmember 170. - Remote deployment of
fastener 180 is accomplished by attachinginner body 154 tofastener actuator 144, and attachingsleeve 156 to thefastener catheter handle 134. Thus, axial movement of thefastener actuator 144 relative to thehandle 134 causes similar relative movement betweeninner body 154 andsleeve 156. For example, in the non-actuated position 148 (seeFIG. 20 ) the distal end ofinner body 154 will extend from sleeve 156 a sufficient distance to holdfastener 180 thereon. In thesecond position 150 theinner body 154 will have been withdrawn into sleeve 156 a sufficient distance to deploy thefastener 180, and in thethird position 152 theinner body 154 will have been withdrawn a sufficient distance to cut the suture leads 176A and 176B. - The present invention also discloses various methods of using the disclose mitral valve repair system to repair discreet tissue portions in vivo. The following paragraphs describe methods of repairing a dysfunctional mitral valve, though those skilled in the art will appreciate that the present invention and procedure may be adapted for use on other valves or in other procedures requiring the attachment of two or more pieces of tissue.
- To repair a dysfunctional or otherwise incompetent heart valve, a guidewire capable of traversing the circulatory system and entering the heart of the patient is introduced into the patient through an endoluminal entry point. For example, the endoluminal entry point may be formed in a femoral vein or right jugular vein. Thereafter, the guidewire is advanced through the circulatory system, eventually arriving at the heart. The guidewire is directed into the right atrium, traverses the right atrium and is made to puncture with the aid of a tran-septal needle or pre-existing hole, the atrial septum, thereby entering the left atrium. As shown in
FIG. 25 , theguidewire 220 may then be advanced through themitral valve 222 and into theleft ventricle 226. Theguidewire 220 traverses theaortic valve 228 into theaorta 230 and is made to emerge at the left femoral artery through an endoluminal exit point. Once theguidewire 220 is positioned, the endoluminal entry or exit port is dilated to permit entry of a catheter therethrough. A protective sheath may be advanced in the venous area to protect the vascular structure. - As shown in
FIG. 26 , theguide catheter 10 of the present invention may be attached to theguidewire 220 and advanced through the dilated guidewire entry port to a point proximate to themitral valve 222. Those skilled in the art will appreciate that the mitral valve repair system of the present invention may approach the mitral valve from an antegrade position or from a retrograde position as desired by the user. Once the guide catheter is suitably positioned in the heart, thetherapy catheter 30 may be advanced through theguide catheter 10 to a position proximate to themitral valve 222.FIG. 27 shows thetherapy catheter 30 emerging from theguide catheter 10 proximate to themitral valve 222. Thereafter, the user may actuate thesuction actuator 52 located on thehandle body 38 of the therapy device handle 34 (FIG. 6 ). As a result, a suction force is applied from thesuction recess 56 formed on thesuture attachment tip 36 of the therapy catheter 30 (FIG. 7 ) to the tissue located proximate thereto. As shown inFIG. 28 , afirst valve leaflet 240A is engaged and retained by the suction force applied through thesuction recess 56. With thefirst valve leaflet 240A stabilized, the user may apply asuture 242A thereto as described above. To apply the first suture to thefirst valve leaflet 240A, the user actuates thefirst actuator 44 located on the therapy device handle 34, which results in thefirst needle 70 advancing through thefirst valve leaflet 240A and engaging and retaining thefirst needle catch 88A, thereby applying afirst suture 242A to the tissue (FIGS. 6-7 ). Thereafter, the user may terminate application of suction force to thefirst valve leaflet 240A thereby releasing the sutured tissue.FIG. 29 shows thefirst valve leaflet 240A having afirst suture 242A applied thereto. As shown inFIG. 30 , thetherapy catheter 30 may then be rotated and positioned to engage asecond valve leaflet 240B. Once again, the user may actuate thesuction actuator 52 to apply suction force to thesecond valve leaflet 240B through thesuction recess 56. With thesecond valve leaflet 240B stabilized as shown inFIG. 30 , the user may apply asuture 242B thereto by actuating thesecond actuator 48 located on the therapy device handle 34, which results in thesecond needle 74 advancing through thesecond valve leaflet 240B and engaging and retaining thesecond needle catch 88B, thereby applying asecond suture 242B to the tissue. As shown inFIG. 31 , the user may terminate the application of suction to the stabilized tissue and remove the therapy catheter from the patient, thereby leaving the first andsecond sutures second valve leaflets second sutures valve leaflets - As shown in
FIGS. 32-33 , thefastener catheter 130 may be attached to theguidewire 220 and will be attached to first andsecond sutures fastener catheter 130 may be inserted into theguide catheter 10 and advanced to a position proximate to themitral valve 222. The user then draws the first andsecond sutures fastener catheter 130 to themitral valve 22, thereby decreasing the distance between the first andsecond valve leaflets fastener actuator 144 which causes thesleeve 156 to engage and apply thefastener 180 to the first andsecond sutures fastener actuator 144 causes the cuttingmember 170 to engage and cut the first andsecond sutures FIG. 34 , after thefastener catheter 130, theguide catheter 10, and theguidewire 220 are removed from the patient, thefastener 180 remains applied to themitral valve 222. -
FIGS. 35-44 describe an alternate method of repairing tissue, specifically valve leaflets in this embodiment, in vivo. As shown inFIG. 35-37 , aguide catheter 10 is advanced through the circulatory system to the right atrium of the heart. Once positioned, adilator 250 is advanced through theguide catheter 10 and is made to puncture the atrial septum, thereby entering the left atrium. Thereafter, theguide catheter 10 is advanced into the left atrium through the punctured atrial septum and positioned proximate to themitral valve 222. As shown inFIG. 38 , thetherapy catheter 30 may be inserted into theguide catheter 10 and advanced to a position proximate to themitral valve 222. As shown inFIG. 39 , an inflatable positioning balloon 252 (discussed above) located on thetherapy catheter 30 is inflated to orient and steady the catheter. Thesuction actuator 52 on the therapy device handle 34 is then actuated to apply a suction force to the suction recess 56 (see.FIG. 6 ). Theinflated balloon 252 engages thesecond valve leaflet 240B which forces thesuction recess 56 towards thefirst valve leaflet 240A, thereby resulting in the stabilization of thefirst valve leaflet 240A as shown inFIG. 40 . As shown inFIG. 41 , the user may then apply thefirst suture 242A to thefirst valve leaflet 240A as described above. Once the suture is applied, the user may deflate theinflatable positioning balloon 252 and rotates thetherapy catheter 30 approximately 180°. Thereafter, the user inflates thepositioning balloon 252 and actuatessuction actuator 52 to apply a suction force to thesuction recess 56. As shown inFIG. 42 , theinflatable positioning balloon 252 is again inflated and made to engage the first valve leaflet 240 thereby forcing thesuction recess 56 to engage thesecond valve leaflet 240B and permitting the stabilization of thesecond valve leaflet 240B as shown inFIG. 42 . Thereafter, the user applies thesecond suture 242B to thesecond valve leaflet 240B as described above.FIGS. 43-44 show the first andsecond valve leaflets second suture therapy catheter 30 is removed from the patient's body and thefastener catheter 130 is used to apply a fastener to the first andsecond sutures - In closing, it is understood that the embodiments of the invention disclosed herein are illustrative of the principals of the invention. Other modifications may be employed which remain within the scope of the present invention. Accordingly, the present invention is not limited to the embodiments shown and described in this disclosure.
Claims (20)
1. A method of repairing tissue within the heart of a patient, comprising;
advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve;
advancing a therapy catheter through the guide catheter to the heart valve;
stabilizing a first leaflet with the therapy catheter;
deploying a first suture material into the stabilized first leaflet;
disengaging the first leaflet from the therapy catheter while leaving the first suture material attached thereto;
stabilizing a second leaflet with the therapy catheter;
deploying a second suture material into the second leaflet;
disengaging the second leaflet from the therapy catheter while leaving the second suture material attached thereto;
removing the therapy catheter from the guide catheter;
advancing a fastener catheter along the first and second suture material through the guide catheter to the heart valve; and
joining the first and second leaflets by reducing a distance between the first and second sutures with a fastener deployed from the fastener catheter.
2. The method of claim 1 , further comprising:
cutting the first and second suture portions.
3. The method of claim 2 , wherein the fastener catheter comprises a suture cutter, and cutting the first and second suture portions is performed by the fastener catheter suture cutter, and wherein the method further comprises:
removing the fastener catheter from the patient.
4. The method of claim 1 , wherein the therapy catheter comprises a suction recess on a first side of the therapy catheter, and the method further comprises:
rotating the therapy catheter, wherein rotating the therapy catheter occurs after disengaging the first leaflet from the therapy catheter, and prior to stabilizing the second leaflet with the therapy catheter.
5. The method of claim 1 , wherein the fastener comprises a memory material and is configured to receive the first and second suture portions and to secure the first and second suture portions when released from the fastener, and the method further comprises:
releasing the fastener from the fastener catheter, whereby the fastener is secured to the first and second suture portions.
6. The method of claim 1 , wherein the fastener comprises one or more engagement members configured to engage and secure the first and second suture portions.
7. A method of repairing tissue within the heart of a patient, comprising;
advancing a guide catheter through a circulatory pathway to a location in the heart;
advancing a therapy catheter through the guide catheter into the heart and adjacent a first heart tissue portion;
stabilizing the first heart tissue portion with the therapy catheter;
deploying a first suture material into the stabilized first heart tissue portion;
disengaging the first heart tissue portion from the therapy catheter while leaving the first suture material attached thereto;
stabilizing a second heart tissue portion with the therapy catheter;
deploying a second suture material into the second heart tissue portion;
disengaging the second heart tissue portion from the therapy catheter while leaving the second suture material attached thereto;
removing the therapy catheter from the guide catheter;
advancing a fastener catheter along the first and second suture material through the guide catheter and into the heart; and
joining the first and second sutures with a fastener deployed from the fastener catheter.
8. The method of claim 7 , wherein further comprising:
pulling the first suture portion and the second suture portion while advancing the fastener catheter along the first and second suture material.
9. The method of claim 8 , wherein the fastener catheter is advanced along the first and second suture material until the fastener catheter is adjacent the first heart tissue portion and the second heart tissue portion, thereby decreasing the distance between the first heart tissue portion and the second heart tissue portion.
10. The method of claim 7 , wherein advancing the fastener catheter comprises advancing the fastener catheter to a position adjacent the first heart tissue portion.
11. The method of claim 7 , wherein advancing the fastener catheter comprises advancing the fastener catheter to a position adjacent the second heart tissue portion.
12. The method of claim 7 , wherein the fastener catheter comprises a suture cutter, and the method further comprises:
cutting the first and second suture portions; and
removing the fastener catheter from the patient.
13. The method of claim 7 , further comprising:
repositioning the therapy catheter, wherein repositioning the therapy catheter adjacent the second heart tissue portion occurs after disengaging the first heart tissue portion from the therapy catheter, and prior to stabilizing the second heart tissue portion with the therapy catheter.
14. The method of claim 13 , wherein repositioning the therapy catheter comprises rotating the therapy catheter.
15. The method of claim 7 , wherein the first heart tissue portion and the second heart tissue portion are at or adjacent a patent foramen ovale.
16. The method of claim 7 , wherein the first heart tissue portion comprises a first valve leaflet.
17. The method of claim 7 , wherein the second heart tissue portion comprises a second valve leaflet.
18. A method of repairing tissue within the heart of a patient, comprising;
advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve;
advancing a therapy catheter through the guide catheter to the heart valve; inflating an inflatable positioning balloon on the therapy catheter;
engaging a second leaflet with the inflatable positioning balloon thereby directing the therapy catheter to a first leaflet;
stabilizing the first leaflet with the therapy catheter;
deploying a first suture material into the stabilized first leaflet;
disengaging the first leaflet from the therapy catheter while leaving the first suture material attached thereto;
engaging the first leaflet with the inflatable positioning balloon thereby directing the therapy catheter to the second leaflet;
stabilizing a second leaflet with the therapy catheter;
deploying a second suture material into the second leaflet;
disengaging the second leaflet from the therapy catheter while leaving the second suture material attached thereto;
deflating the inflatable positioning balloon;
removing the therapy catheter from the guide catheter;
advancing a fastener catheter along the first and second suture material through the guide catheter to the heart valve; and
joining the first and second leaflets by reducing a distance between the first and second sutures with a fastener deployed from the fastener catheter.
19. The method of claim 18 , further comprising:
cutting the first and second suture portions.
20. The method of claim 19 , wherein the fastener catheter comprises a suture cutter, and cutting the first and second suture portions is performed by the fastener catheter suture cutter, and wherein the method further comprises:
removing the fastener catheter from the patient.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/129,574 US20080228201A1 (en) | 2003-03-14 | 2008-05-29 | Mitral valve repair system and method for use |
US12/552,972 US8226666B2 (en) | 2003-03-14 | 2009-09-02 | Mitral valve repair system and method for use |
US13/556,039 US8777991B2 (en) | 2003-03-14 | 2012-07-23 | Mitral valve repair system and method for use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/389,721 US7381210B2 (en) | 2003-03-14 | 2003-03-14 | Mitral valve repair system and method for use |
US12/129,574 US20080228201A1 (en) | 2003-03-14 | 2008-05-29 | Mitral valve repair system and method for use |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/389,721 Division US7381210B2 (en) | 2003-03-14 | 2003-03-14 | Mitral valve repair system and method for use |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/552,972 Division US8226666B2 (en) | 2003-03-14 | 2009-09-02 | Mitral valve repair system and method for use |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080228201A1 true US20080228201A1 (en) | 2008-09-18 |
Family
ID=32962331
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/389,721 Active 2025-01-15 US7381210B2 (en) | 2003-03-14 | 2003-03-14 | Mitral valve repair system and method for use |
US12/129,574 Abandoned US20080228201A1 (en) | 2003-03-14 | 2008-05-29 | Mitral valve repair system and method for use |
US12/552,972 Expired - Lifetime US8226666B2 (en) | 2003-03-14 | 2009-09-02 | Mitral valve repair system and method for use |
US13/556,039 Expired - Lifetime US8777991B2 (en) | 2003-03-14 | 2012-07-23 | Mitral valve repair system and method for use |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/389,721 Active 2025-01-15 US7381210B2 (en) | 2003-03-14 | 2003-03-14 | Mitral valve repair system and method for use |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/552,972 Expired - Lifetime US8226666B2 (en) | 2003-03-14 | 2009-09-02 | Mitral valve repair system and method for use |
US13/556,039 Expired - Lifetime US8777991B2 (en) | 2003-03-14 | 2012-07-23 | Mitral valve repair system and method for use |
Country Status (6)
Country | Link |
---|---|
US (4) | US7381210B2 (en) |
EP (2) | EP1605833A2 (en) |
JP (1) | JP4558718B2 (en) |
AU (1) | AU2004222384A1 (en) |
CA (2) | CA2518962C (en) |
WO (1) | WO2004082523A2 (en) |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110190793A1 (en) * | 2010-01-29 | 2011-08-04 | Med-Venture Investments, Llc | Methods and apparatuses for suturing of cardiac openings |
KR101116867B1 (en) | 2009-08-28 | 2012-03-06 | 김준홍 | The device for delivering optimal tension safaely and effectively in cerclage annuloplasty procedure |
WO2012043898A1 (en) * | 2010-09-29 | 2012-04-05 | Kim June-Hong | Tissue protective device for coronary sinus and tricuspid valve, knot delivery device, and device for mitral valve cerclage, containing same |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US20140155990A1 (en) * | 2012-05-30 | 2014-06-05 | Neovasc Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
KR101467373B1 (en) * | 2013-05-23 | 2014-12-10 | 부산대학교 산학협력단 | Stopper for myocardial protection and cerclage annuloplasty procedure apparatus with the same |
US9131938B2 (en) | 2007-03-29 | 2015-09-15 | Nobles Medical Technologies, Inc. | Suturing devices and methods for closing a patent foramen ovale |
WO2015178612A1 (en) * | 2014-05-20 | 2015-11-26 | (주)타우피엔유메디칼 | Tissue protection device for mitral valve membrane cerclage procedure |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9326764B2 (en) | 2008-05-09 | 2016-05-03 | Nobles Medical Technologies Inc. | Suturing devices and methods for suturing an anatomic valve |
US9398907B2 (en) | 1999-07-02 | 2016-07-26 | Quickpass, Inc. | Suturing device |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
US9642616B2 (en) | 2005-06-20 | 2017-05-09 | Nobles Medical Technologies, Inc. | Method and apparatus for applying a knot to a suture |
US9649106B2 (en) | 2011-04-15 | 2017-05-16 | Heartstitch, Inc. | Suturing devices and methods for suturing an anatomic valve |
US9706988B2 (en) | 2012-05-11 | 2017-07-18 | Heartstitch, Inc. | Suturing devices and methods for suturing an anatomic structure |
US10512458B2 (en) | 2013-12-06 | 2019-12-24 | Med-Venture Investments, Llc | Suturing methods and apparatuses |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
US10687801B2 (en) | 2016-04-11 | 2020-06-23 | Nobles Medical Technologies Ii, Inc. | Suture spools for tissue suturing device |
US10828022B2 (en) | 2013-07-02 | 2020-11-10 | Med-Venture Investments, Llc | Suturing devices and methods for suturing an anatomic structure |
US11026791B2 (en) | 2018-03-20 | 2021-06-08 | Medtronic Vascular, Inc. | Flexible canopy valve repair systems and methods of use |
US11202624B2 (en) | 2017-08-18 | 2021-12-21 | Nobles Medical Technologies Ii, Inc. | Apparatus for applying a knot to a suture |
US11285003B2 (en) | 2018-03-20 | 2022-03-29 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
US11395658B2 (en) | 2014-07-11 | 2022-07-26 | Cardio Medical Solutions, Inc. | Device and method for assisting end-to-side anastomosis |
US11779742B2 (en) | 2019-05-20 | 2023-10-10 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
US11839370B2 (en) | 2017-06-19 | 2023-12-12 | Heartstitch, Inc. | Suturing devices and methods for suturing an opening in the apex of the heart |
US11957331B2 (en) | 2017-06-19 | 2024-04-16 | Heartstitch, Inc. | Suturing systems and methods for suturing body tissue |
Families Citing this family (427)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
US6050936A (en) | 1997-01-02 | 2000-04-18 | Myocor, Inc. | Heart wall tension reduction apparatus |
FR2768324B1 (en) | 1997-09-12 | 1999-12-10 | Jacques Seguin | SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER |
US6332893B1 (en) | 1997-12-17 | 2001-12-25 | Myocor, Inc. | Valve to myocardium tension members device and method |
US6260552B1 (en) | 1998-07-29 | 2001-07-17 | Myocor, Inc. | Transventricular implant tools and devices |
US7842048B2 (en) | 2006-08-18 | 2010-11-30 | Abbott Laboratories | Articulating suture device and method |
US7235087B2 (en) | 1999-03-04 | 2007-06-26 | Abbott Park | Articulating suturing device and method |
US7001400B1 (en) | 1999-03-04 | 2006-02-21 | Abbott Laboratories | Articulating suturing device and method |
US20040092964A1 (en) | 1999-03-04 | 2004-05-13 | Modesitt D. Bruce | Articulating suturing device and method |
US6964668B2 (en) | 1999-03-04 | 2005-11-15 | Abbott Laboratories | Articulating suturing device and method |
US8137364B2 (en) | 2003-09-11 | 2012-03-20 | Abbott Laboratories | Articulating suturing device and method |
US6752813B2 (en) | 1999-04-09 | 2004-06-22 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
ATE484241T1 (en) | 1999-04-09 | 2010-10-15 | Evalve Inc | METHOD AND DEVICE FOR HEART VALVE REPAIR |
US20040044350A1 (en) | 1999-04-09 | 2004-03-04 | Evalve, Inc. | Steerable access sheath and methods of use |
US8216256B2 (en) | 1999-04-09 | 2012-07-10 | Evalve, Inc. | Detachment mechanism for implantable fixation devices |
US7563267B2 (en) | 1999-04-09 | 2009-07-21 | Evalve, Inc. | Fixation device and methods for engaging tissue |
US10327743B2 (en) | 1999-04-09 | 2019-06-25 | Evalve, Inc. | Device and methods for endoscopic annuloplasty |
US7811296B2 (en) | 1999-04-09 | 2010-10-12 | Evalve, Inc. | Fixation devices for variation in engagement of tissue |
US6461364B1 (en) | 2000-01-05 | 2002-10-08 | Integrated Vascular Systems, Inc. | Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use |
US9579091B2 (en) | 2000-01-05 | 2017-02-28 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US8758400B2 (en) | 2000-01-05 | 2014-06-24 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US7842068B2 (en) | 2000-12-07 | 2010-11-30 | Integrated Vascular Systems, Inc. | Apparatus and methods for providing tactile feedback while delivering a closure device |
US6391048B1 (en) | 2000-01-05 | 2002-05-21 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant and methods of use |
US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
US7083628B2 (en) | 2002-09-03 | 2006-08-01 | Edwards Lifesciences Corporation | Single catheter mitral valve repair device and method for use |
SE0002878D0 (en) * | 2000-08-11 | 2000-08-11 | Kimblad Ola | Device and method of treatment of atrioventricular regurgitation |
AU8800801A (en) | 2000-09-08 | 2002-03-22 | James E Coleman | Surgical staple |
US6626918B1 (en) | 2000-10-06 | 2003-09-30 | Medical Technology Group | Apparatus and methods for positioning a vascular sheath |
US6723038B1 (en) | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US6602286B1 (en) | 2000-10-26 | 2003-08-05 | Ernst Peter Strecker | Implantable valve system |
US7905900B2 (en) | 2003-01-30 | 2011-03-15 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US6623510B2 (en) | 2000-12-07 | 2003-09-23 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US7211101B2 (en) | 2000-12-07 | 2007-05-01 | Abbott Vascular Devices | Methods for manufacturing a clip and clip |
US8690910B2 (en) | 2000-12-07 | 2014-04-08 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US7556646B2 (en) | 2001-09-13 | 2009-07-07 | Edwards Lifesciences Corporation | Methods and apparatuses for deploying minimally-invasive heart valves |
US6733525B2 (en) | 2001-03-23 | 2004-05-11 | Edwards Lifesciences Corporation | Rolled minimally-invasive heart valves and methods of use |
US6770080B2 (en) | 2001-04-26 | 2004-08-03 | Fenestra Medical, Inc. | Mechanically registered videoscopic myringotomy/tympanostomy tube placement system |
IES20010547A2 (en) | 2001-06-07 | 2002-12-11 | Christy Cummins | Surgical Staple |
US6893460B2 (en) | 2001-10-11 | 2005-05-17 | Percutaneous Valve Technologies Inc. | Implantable prosthetic valve |
US6575971B2 (en) | 2001-11-15 | 2003-06-10 | Quantum Cor, Inc. | Cardiac valve leaflet stapler device and methods thereof |
US6764510B2 (en) | 2002-01-09 | 2004-07-20 | Myocor, Inc. | Devices and methods for heart valve treatment |
US6749621B2 (en) | 2002-02-21 | 2004-06-15 | Integrated Vascular Systems, Inc. | Sheath apparatus and methods for delivering a closure device |
US7048754B2 (en) | 2002-03-01 | 2006-05-23 | Evalve, Inc. | Suture fasteners and methods of use |
US6752828B2 (en) | 2002-04-03 | 2004-06-22 | Scimed Life Systems, Inc. | Artificial valve |
DE60325355D1 (en) | 2002-06-04 | 2009-01-29 | Abbott Vascular Inc | SURGICAL CLOSURE AND MOUNTING DEVICE FOR VASCULAR SEALING |
US8287555B2 (en) | 2003-02-06 | 2012-10-16 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US20060122633A1 (en) | 2002-06-13 | 2006-06-08 | John To | Methods and devices for termination |
AU2003245507A1 (en) | 2002-06-13 | 2003-12-31 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US7753924B2 (en) | 2003-09-04 | 2010-07-13 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US7666193B2 (en) | 2002-06-13 | 2010-02-23 | Guided Delivery Sytems, Inc. | Delivery devices and methods for heart valve repair |
US7753922B2 (en) | 2003-09-04 | 2010-07-13 | Guided Delivery Systems, Inc. | Devices and methods for cardiac annulus stabilization and treatment |
US7883538B2 (en) | 2002-06-13 | 2011-02-08 | Guided Delivery Systems Inc. | Methods and devices for termination |
US7758637B2 (en) | 2003-02-06 | 2010-07-20 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US7753858B2 (en) | 2002-06-13 | 2010-07-13 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US9949829B2 (en) | 2002-06-13 | 2018-04-24 | Ancora Heart, Inc. | Delivery devices and methods for heart valve repair |
US8641727B2 (en) | 2002-06-13 | 2014-02-04 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US8758372B2 (en) | 2002-08-29 | 2014-06-24 | St. Jude Medical, Cardiology Division, Inc. | Implantable devices for controlling the size and shape of an anatomical structure or lumen |
JP4316503B2 (en) * | 2002-08-29 | 2009-08-19 | ミトラルソリューションズ、インコーポレイテッド | Implantable device for controlling an anatomical orifice or lumen |
US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
US6945957B2 (en) | 2002-12-30 | 2005-09-20 | Scimed Life Systems, Inc. | Valve treatment catheter and methods |
US7160309B2 (en) | 2002-12-31 | 2007-01-09 | Laveille Kao Voss | Systems for anchoring a medical device in a body lumen |
US8905937B2 (en) | 2009-02-26 | 2014-12-09 | Integrated Vascular Systems, Inc. | Methods and apparatus for locating a surface of a body lumen |
US8202293B2 (en) | 2003-01-30 | 2012-06-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8398656B2 (en) | 2003-01-30 | 2013-03-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8758398B2 (en) | 2006-09-08 | 2014-06-24 | Integrated Vascular Systems, Inc. | Apparatus and method for delivering a closure element |
US8821534B2 (en) | 2010-12-06 | 2014-09-02 | Integrated Vascular Systems, Inc. | Clip applier having improved hemostasis and methods of use |
US7381210B2 (en) | 2003-03-14 | 2008-06-03 | Edwards Lifesciences Corporation | Mitral valve repair system and method for use |
US10646229B2 (en) | 2003-05-19 | 2020-05-12 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US7462188B2 (en) | 2003-09-26 | 2008-12-09 | Abbott Laboratories | Device and method for suturing intracardiac defects |
US7854761B2 (en) | 2003-12-19 | 2010-12-21 | Boston Scientific Scimed, Inc. | Methods for venous valve replacement with a catheter |
US8128681B2 (en) | 2003-12-19 | 2012-03-06 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7449024B2 (en) | 2003-12-23 | 2008-11-11 | Abbott Laboratories | Suturing device with split arm and method of suturing tissue |
US20050267520A1 (en) | 2004-05-12 | 2005-12-01 | Modesitt D B | Access and closure device and method |
CA2566666C (en) | 2004-05-14 | 2014-05-13 | Evalve, Inc. | Locking mechanisms for fixation devices and methods of engaging tissue |
IES20040368A2 (en) | 2004-05-25 | 2005-11-30 | James E Coleman | Surgical stapler |
US7566343B2 (en) | 2004-09-02 | 2009-07-28 | Boston Scientific Scimed, Inc. | Cardiac valve, system, and method |
US8052592B2 (en) | 2005-09-27 | 2011-11-08 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US7635329B2 (en) | 2004-09-27 | 2009-12-22 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
DE102005003632A1 (en) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Catheter for the transvascular implantation of heart valve prostheses |
CA2595459C (en) * | 2005-01-21 | 2013-11-26 | Mayo Foundation For Medical Education And Research | Thorascopic heart valve repair method and apparatus |
US20060173490A1 (en) | 2005-02-01 | 2006-08-03 | Boston Scientific Scimed, Inc. | Filter system and method |
US7854755B2 (en) | 2005-02-01 | 2010-12-21 | Boston Scientific Scimed, Inc. | Vascular catheter, system, and method |
JP4716745B2 (en) * | 2005-02-04 | 2011-07-06 | オリンパス株式会社 | Medical suture ligation apparatus and medical suture ligation tool |
US7878966B2 (en) | 2005-02-04 | 2011-02-01 | Boston Scientific Scimed, Inc. | Ventricular assist and support device |
US8470028B2 (en) | 2005-02-07 | 2013-06-25 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
US7780722B2 (en) | 2005-02-07 | 2010-08-24 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
CA2597066C (en) | 2005-02-07 | 2014-04-15 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
US7670368B2 (en) | 2005-02-07 | 2010-03-02 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7867274B2 (en) | 2005-02-23 | 2011-01-11 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
EP1861045B1 (en) * | 2005-03-25 | 2015-03-04 | St. Jude Medical, Cardiology Division, Inc. | Apparatus for controlling the internal circumference of an anatomic orifice or lumen |
US8864823B2 (en) | 2005-03-25 | 2014-10-21 | StJude Medical, Cardiology Division, Inc. | Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen |
US7722666B2 (en) | 2005-04-15 | 2010-05-25 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US7674271B2 (en) * | 2005-05-04 | 2010-03-09 | InTailor Surgical, Inc. | Endoluminal gastric ring and method |
CN101217916B (en) | 2005-05-12 | 2013-04-10 | 阿尔斯塔西斯公司 | Access and closure device and method |
US8012198B2 (en) | 2005-06-10 | 2011-09-06 | Boston Scientific Scimed, Inc. | Venous valve, system, and method |
US8926633B2 (en) | 2005-06-24 | 2015-01-06 | Abbott Laboratories | Apparatus and method for delivering a closure element |
US20070005079A1 (en) * | 2005-06-30 | 2007-01-04 | David Zarbatany | System, apparatus, and method for repairing septal defects |
US8252005B2 (en) * | 2005-06-30 | 2012-08-28 | Edwards Lifesciences Corporation | System, apparatus, and method for fastening tissue |
US8313497B2 (en) | 2005-07-01 | 2012-11-20 | Abbott Laboratories | Clip applier and methods of use |
US8641729B2 (en) * | 2005-07-13 | 2014-02-04 | Creighton University | Systems and techniques for minimally invasive gastrointestinal procedures |
US7883517B2 (en) | 2005-08-08 | 2011-02-08 | Abbott Laboratories | Vascular suturing device |
US8083754B2 (en) * | 2005-08-08 | 2011-12-27 | Abbott Laboratories | Vascular suturing device with needle capture |
WO2007019016A1 (en) | 2005-08-08 | 2007-02-15 | Abbott Laboratories | Vascular suturing device |
US20070032801A1 (en) * | 2005-08-08 | 2007-02-08 | Pantages Anthony J | Vascular suturing device |
US9456811B2 (en) | 2005-08-24 | 2016-10-04 | Abbott Vascular Inc. | Vascular closure methods and apparatuses |
US20070060895A1 (en) | 2005-08-24 | 2007-03-15 | Sibbitt Wilmer L Jr | Vascular closure methods and apparatuses |
US8920442B2 (en) | 2005-08-24 | 2014-12-30 | Abbott Vascular Inc. | Vascular opening edge eversion methods and apparatuses |
US7569071B2 (en) | 2005-09-21 | 2009-08-04 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US8778017B2 (en) | 2005-10-26 | 2014-07-15 | Cardiosolutions, Inc. | Safety for mitral valve implant |
US9259317B2 (en) | 2008-06-13 | 2016-02-16 | Cardiosolutions, Inc. | System and method for implanting a heart implant |
US7785366B2 (en) * | 2005-10-26 | 2010-08-31 | Maurer Christopher W | Mitral spacer |
US8852270B2 (en) | 2007-11-15 | 2014-10-07 | Cardiosolutions, Inc. | Implant delivery system and method |
US8216302B2 (en) | 2005-10-26 | 2012-07-10 | Cardiosolutions, Inc. | Implant delivery and deployment system and method |
US8449606B2 (en) | 2005-10-26 | 2013-05-28 | Cardiosolutions, Inc. | Balloon mitral spacer |
US8092525B2 (en) | 2005-10-26 | 2012-01-10 | Cardiosolutions, Inc. | Heart valve implant |
US20070232941A1 (en) * | 2005-10-27 | 2007-10-04 | Stan Rabinovich | System, apparatus, and method for imaging and treating tissue |
US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
US7799038B2 (en) | 2006-01-20 | 2010-09-21 | Boston Scientific Scimed, Inc. | Translumenal apparatus, system, and method |
US7628797B2 (en) | 2006-01-31 | 2009-12-08 | Edwards Lifesciences Corporation | System, apparatus, and method for fastening tissue |
US8808310B2 (en) | 2006-04-20 | 2014-08-19 | Integrated Vascular Systems, Inc. | Resettable clip applier and reset tools |
US7731727B2 (en) | 2006-04-26 | 2010-06-08 | Lsi Solutions, Inc. | Medical instrument to place a pursestring suture, open a hole and pass a guidewire |
US9511214B2 (en) | 2006-05-02 | 2016-12-06 | Vascular Access Technologies, Inc. | Methods of transvascular retrograde access placement and devices for facilitating therein |
US8556930B2 (en) | 2006-06-28 | 2013-10-15 | Abbott Laboratories | Vessel closure device |
AU2007285898B2 (en) * | 2006-08-16 | 2013-07-11 | Cook Medical Technologies Llc | Suturing device |
US20080065156A1 (en) | 2006-09-08 | 2008-03-13 | Hauser David L | Expandable clip for tissue repair |
US8388680B2 (en) | 2006-10-18 | 2013-03-05 | Guided Delivery Systems, Inc. | Methods and devices for catheter advancement and delivery of substances therethrough |
US8236045B2 (en) | 2006-12-22 | 2012-08-07 | Edwards Lifesciences Corporation | Implantable prosthetic valve assembly and method of making the same |
CA2674485A1 (en) | 2007-01-03 | 2008-07-17 | Mitralsolutions, Inc. | Implantable devices for controlling the size and shape of an anatomical structure or lumen |
WO2008091493A1 (en) | 2007-01-08 | 2008-07-31 | California Institute Of Technology | In-situ formation of a valve |
WO2008097999A2 (en) | 2007-02-05 | 2008-08-14 | Mitralsolutions, Inc. | Minimally invasive system for delivering and securing an annular implant |
JP5313928B2 (en) | 2007-02-05 | 2013-10-09 | ボストン サイエンティフィック リミテッド | Percutaneous valves and systems |
EP2114304B1 (en) | 2007-02-14 | 2017-09-06 | Edwards Lifesciences Corporation | implantable medical device for repairing heart |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US8425488B2 (en) * | 2007-04-19 | 2013-04-23 | Acclarent, Inc. | System and method for the simultaneous bilateral treatment of target tissues within the ears using a guide block structure |
US8753373B2 (en) * | 2007-05-08 | 2014-06-17 | Edwards Lifesciences Corporation | Suture-fastening clip |
US8480730B2 (en) | 2007-05-14 | 2013-07-09 | Cardiosolutions, Inc. | Solid construct mitral spacer |
US8574244B2 (en) | 2007-06-25 | 2013-11-05 | Abbott Laboratories | System for closing a puncture in a vessel wall |
US8828079B2 (en) | 2007-07-26 | 2014-09-09 | Boston Scientific Scimed, Inc. | Circulatory valve, system and method |
DE102007043830A1 (en) | 2007-09-13 | 2009-04-02 | Lozonschi, Lucian, Madison | Heart valve stent |
CA2703129C (en) | 2007-10-18 | 2016-02-16 | Neochord Inc. | Minimially invasive repair of a valve leaflet in a beating heart |
US8197464B2 (en) * | 2007-10-19 | 2012-06-12 | Cordis Corporation | Deflecting guide catheter for use in a minimally invasive medical procedure for the treatment of mitral valve regurgitation |
US8597347B2 (en) | 2007-11-15 | 2013-12-03 | Cardiosolutions, Inc. | Heart regurgitation method and apparatus |
US8893947B2 (en) | 2007-12-17 | 2014-11-25 | Abbott Laboratories | Clip applier and methods of use |
US20090157101A1 (en) | 2007-12-17 | 2009-06-18 | Abbott Laboratories | Tissue closure system and methods of use |
US7841502B2 (en) | 2007-12-18 | 2010-11-30 | Abbott Laboratories | Modular clip applier |
US8192420B2 (en) | 2007-12-20 | 2012-06-05 | Acclarent, Inc. | Iontophoresis methods |
US7892276B2 (en) | 2007-12-21 | 2011-02-22 | Boston Scientific Scimed, Inc. | Valve with delayed leaflet deployment |
WO2009100242A2 (en) | 2008-02-06 | 2009-08-13 | Guided Delivery Systems, Inc. | Multi-window guide tunnel |
ES2903231T3 (en) | 2008-02-26 | 2022-03-31 | Jenavalve Tech Inc | Stent for positioning and anchoring a valve prosthesis at an implantation site in a patient's heart |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
EP2265225B1 (en) | 2008-02-29 | 2013-02-13 | Edwards Lifesciences Corporation | Expandable member for deploying a prosthetic device |
AU2009221903B2 (en) * | 2008-03-04 | 2015-07-02 | Cayenne Medical, Inc. | Arthroscopic meniscal repair systems and methods |
US20090276040A1 (en) | 2008-05-01 | 2009-11-05 | Edwards Lifesciences Corporation | Device and method for replacing mitral valve |
CA2723810C (en) | 2008-05-07 | 2015-06-30 | Guided Delivery Systems, Inc. | Deflectable guide |
US9282965B2 (en) | 2008-05-16 | 2016-03-15 | Abbott Laboratories | Apparatus and methods for engaging tissue |
US8591460B2 (en) | 2008-06-13 | 2013-11-26 | Cardiosolutions, Inc. | Steerable catheter and dilator and system and method for implanting a heart implant |
US8323335B2 (en) | 2008-06-20 | 2012-12-04 | Edwards Lifesciences Corporation | Retaining mechanisms for prosthetic valves and methods for using |
EP2312993A4 (en) | 2008-07-21 | 2015-03-11 | Arstasis Inc | Devices, methods, and kits for forming tracts in tissue |
US20100023118A1 (en) * | 2008-07-24 | 2010-01-28 | Edwards Lifesciences Corporation | Method and apparatus for repairing or replacing chordae tendinae |
US8452392B2 (en) * | 2008-07-31 | 2013-05-28 | Acclarent, Inc. | Systems and methods for anesthetizing ear tissue |
US8840602B2 (en) * | 2008-07-31 | 2014-09-23 | Acclarent, Inc. | Systems and methods for anesthetizing ear tissue |
US8778016B2 (en) * | 2008-08-14 | 2014-07-15 | Edwards Lifesciences Corporation | Method and apparatus for repairing or replacing chordae tendinae |
US8652202B2 (en) | 2008-08-22 | 2014-02-18 | Edwards Lifesciences Corporation | Prosthetic heart valve and delivery apparatus |
AU2009302169B2 (en) | 2008-10-10 | 2016-01-14 | Ancora Heart, Inc. | Termination devices and related methods |
EP2349020B1 (en) | 2008-10-10 | 2020-06-03 | Ancora Heart, Inc. | Tether tensioning device |
US8690936B2 (en) | 2008-10-10 | 2014-04-08 | Edwards Lifesciences Corporation | Expandable sheath for introducing an endovascular delivery device into a body |
WO2010048333A2 (en) * | 2008-10-21 | 2010-04-29 | Cayenne Medical, Inc. | Meniscal repair systems and methods |
US8398676B2 (en) | 2008-10-30 | 2013-03-19 | Abbott Vascular Inc. | Closure device |
US8551123B2 (en) * | 2008-11-13 | 2013-10-08 | Rajiv D. Pandya | Device for the intraosteal seizing of sutures |
US8858594B2 (en) | 2008-12-22 | 2014-10-14 | Abbott Laboratories | Curved closure device |
US9078783B2 (en) * | 2008-12-24 | 2015-07-14 | Acclarent, Inc. | Silent effusion removal |
US9173644B2 (en) | 2009-01-09 | 2015-11-03 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9089311B2 (en) | 2009-01-09 | 2015-07-28 | Abbott Vascular Inc. | Vessel closure devices and methods |
US9414820B2 (en) | 2009-01-09 | 2016-08-16 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9486191B2 (en) | 2009-01-09 | 2016-11-08 | Abbott Vascular, Inc. | Closure devices |
US20100198192A1 (en) | 2009-01-20 | 2010-08-05 | Eugene Serina | Anchor deployment devices and related methods |
JP2012515625A (en) * | 2009-01-22 | 2012-07-12 | セント・ジュード・メディカル,カーディオロジー・ディヴィジョン,インコーポレイテッド | Magnetic docking system and method for long term adjustment of implantable devices |
US8808371B2 (en) | 2009-01-22 | 2014-08-19 | St. Jude Medical, Cardiology Division, Inc. | Post-operative adjustment tool, minimally invasive attachment apparatus, and adjustable tricuspid ring |
EP2389118B1 (en) * | 2009-01-26 | 2019-05-15 | Synthes GmbH | Bi-directional suture passer |
CA2961053C (en) | 2009-04-15 | 2019-04-30 | Edwards Lifesciences Cardiaq Llc | Vascular implant and delivery system |
EP2424442A4 (en) * | 2009-05-01 | 2015-05-20 | Cayenne Medical Inc | Meniscal repair systems and methods |
US9770366B2 (en) | 2009-07-15 | 2017-09-26 | Tusker Medical, Inc. | Tympanic membrane pressure equalization tube delivery system |
JP5596142B2 (en) * | 2009-07-15 | 2014-09-24 | アクラレント インコーポレイテッド | Tympanic pressure equalizing tube delivery system |
US9539146B2 (en) | 2009-07-15 | 2017-01-10 | Tusker Medical, Inc. | Trigger assembly for tympanostomy tube delivery device |
US8409236B2 (en) | 2009-08-21 | 2013-04-02 | Vascular Access Technologies, Inc. | Methods of transvascular retrograde access placement and devices for facilitating the placement |
US20110046642A1 (en) * | 2009-08-21 | 2011-02-24 | Coloplast A/S | Suture assembly and system |
EP2477555B1 (en) | 2009-09-15 | 2013-12-25 | Evalve, Inc. | Device for cardiac valve repair |
DE102009055969A1 (en) * | 2009-11-27 | 2011-06-01 | Transcatheter Technologies Gmbh | Device and set for folding or unfolding a medical implant and method |
US8449599B2 (en) | 2009-12-04 | 2013-05-28 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
JP2013512765A (en) | 2009-12-08 | 2013-04-18 | アヴァロン メディカル リミテッド | Devices and systems for transcatheter mitral valve replacement |
US9307980B2 (en) | 2010-01-22 | 2016-04-12 | 4Tech Inc. | Tricuspid valve repair using tension |
US8475525B2 (en) | 2010-01-22 | 2013-07-02 | 4Tech Inc. | Tricuspid valve repair using tension |
US10058323B2 (en) | 2010-01-22 | 2018-08-28 | 4 Tech Inc. | Tricuspid valve repair using tension |
US9107749B2 (en) | 2010-02-03 | 2015-08-18 | Edwards Lifesciences Corporation | Methods for treating a heart |
US8398659B2 (en) * | 2010-03-12 | 2013-03-19 | Coloplast A/S | Method of intracorporeally suturing tissue |
WO2011135400A1 (en) | 2010-04-30 | 2011-11-03 | Indian Institute Of Technology Bombay | Nanoparticulate in-situ gels as vitreous humor substitutes for ocular diseases |
US9155533B2 (en) | 2010-05-06 | 2015-10-13 | DePuy Synthes Products, Inc. | Soft tissue defect device and associated method |
BR112012029896A2 (en) | 2010-05-25 | 2017-06-20 | Jenavalve Tech Inc | prosthetic heart valve for stent graft and stent graft |
US20110306992A1 (en) | 2010-06-09 | 2011-12-15 | C.R. Bard, Inc. | Instruments for delivering transfascial sutures, transfascial suture assemblies, and methods of transfascial suturing |
US8758399B2 (en) | 2010-08-02 | 2014-06-24 | Abbott Cardiovascular Systems, Inc. | Expandable bioabsorbable plug apparatus and method |
US9370353B2 (en) | 2010-09-01 | 2016-06-21 | Abbott Cardiovascular Systems, Inc. | Suturing devices and methods |
US8663252B2 (en) | 2010-09-01 | 2014-03-04 | Abbott Cardiovascular Systems, Inc. | Suturing devices and methods |
US9861350B2 (en) | 2010-09-03 | 2018-01-09 | Ancora Heart, Inc. | Devices and methods for anchoring tissue |
CA3035048C (en) | 2010-12-23 | 2021-05-04 | Mark Deem | System for mitral valve repair and replacement |
EP2658480B1 (en) | 2010-12-29 | 2017-11-01 | Neochord Inc. | Exchangeable system for minimally invasive beating heart repair of heart valve leaflets |
US8777966B2 (en) | 2011-02-01 | 2014-07-15 | St. Jude Medical, Inc. | Apparatus and method for heart valve repair |
US8617184B2 (en) | 2011-02-15 | 2013-12-31 | Abbott Cardiovascular Systems, Inc. | Vessel closure system |
US9155619B2 (en) | 2011-02-25 | 2015-10-13 | Edwards Lifesciences Corporation | Prosthetic heart valve delivery apparatus |
US9149276B2 (en) * | 2011-03-21 | 2015-10-06 | Abbott Cardiovascular Systems, Inc. | Clip and deployment apparatus for tissue closure |
US8974476B2 (en) * | 2011-03-23 | 2015-03-10 | St. Jude Medical Puerto Rico Llc | Vascular closure device with compaction tube suture cutting port and methods |
US9414822B2 (en) | 2011-05-19 | 2016-08-16 | Abbott Cardiovascular Systems, Inc. | Tissue eversion apparatus and tissue closure device and methods for use thereof |
US9289282B2 (en) | 2011-05-31 | 2016-03-22 | Edwards Lifesciences Corporation | System and method for treating valve insufficiency or vessel dilatation |
CA2837206C (en) | 2011-06-01 | 2019-09-24 | John Zentgraf | Minimally invasive repair of heart valve leaflets |
AU2012272855C1 (en) | 2011-06-21 | 2018-04-05 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US8992550B2 (en) * | 2011-07-20 | 2015-03-31 | Coloplast A/S | Suture system with capsule eyelet providing multiple suture tissue fixation |
CN103826581B (en) | 2011-07-25 | 2016-05-04 | 阿克拉伦特公司 | For anaesthetizing personalization system and the method for eardrum |
US9119716B2 (en) | 2011-07-27 | 2015-09-01 | Edwards Lifesciences Corporation | Delivery systems for prosthetic heart valve |
US9668859B2 (en) | 2011-08-05 | 2017-06-06 | California Institute Of Technology | Percutaneous heart valve delivery systems |
AU2012299311B2 (en) | 2011-08-11 | 2016-03-03 | Tendyne Holdings, Inc. | Improvements for prosthetic valves and related inventions |
US8945177B2 (en) | 2011-09-13 | 2015-02-03 | Abbott Cardiovascular Systems Inc. | Gripper pusher mechanism for tissue apposition systems |
US10016271B2 (en) | 2011-10-19 | 2018-07-10 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9039757B2 (en) | 2011-10-19 | 2015-05-26 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
EP2750630B1 (en) | 2011-10-19 | 2021-06-30 | Twelve, Inc. | Device for heart valve replacement |
US9763780B2 (en) | 2011-10-19 | 2017-09-19 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9078648B2 (en) | 2011-11-07 | 2015-07-14 | C.R. Bard, Inc. | Instruments for delivering transfascial sutures and methods of transfascial suturing |
US9332976B2 (en) | 2011-11-30 | 2016-05-10 | Abbott Cardiovascular Systems, Inc. | Tissue closure device |
US8968336B2 (en) | 2011-12-07 | 2015-03-03 | Edwards Lifesciences Corporation | Self-cinching surgical clips and delivery system |
US9827092B2 (en) | 2011-12-16 | 2017-11-28 | Tendyne Holdings, Inc. | Tethers for prosthetic mitral valve |
US9078652B2 (en) | 2011-12-19 | 2015-07-14 | Edwards Lifesciences Corporation | Side-entry knotless suture anchoring clamps and deployment tools |
US9078645B2 (en) | 2011-12-19 | 2015-07-14 | Edwards Lifesciences Corporation | Knotless suture anchoring devices and tools for implants |
US9017347B2 (en) | 2011-12-22 | 2015-04-28 | Edwards Lifesciences Corporation | Suture clip deployment devices |
US9610082B2 (en) | 2012-01-25 | 2017-04-04 | St. Jude Medical, Inc. | Apparatus and method for heart valve repair |
EP2806804B1 (en) | 2012-01-25 | 2018-08-29 | St. Jude Medical, LLC | Apparatus for heart valve repair |
WO2013116617A1 (en) | 2012-02-02 | 2013-08-08 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method for heart valve repair |
US10076414B2 (en) | 2012-02-13 | 2018-09-18 | Mitraspan, Inc. | Method and apparatus for repairing a mitral valve |
EP2814428A4 (en) | 2012-02-13 | 2016-05-25 | Mitraspan Inc | Method and apparatus for repairing a mitral valve |
US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
US8858573B2 (en) | 2012-04-10 | 2014-10-14 | Abbott Cardiovascular Systems, Inc. | Apparatus and method for suturing body lumens |
US8864778B2 (en) | 2012-04-10 | 2014-10-21 | Abbott Cardiovascular Systems, Inc. | Apparatus and method for suturing body lumens |
US20130317438A1 (en) | 2012-05-25 | 2013-11-28 | Arstasis, Inc. | Vascular access configuration |
US20130317481A1 (en) | 2012-05-25 | 2013-11-28 | Arstasis, Inc. | Vascular access configuration |
US9623217B2 (en) | 2012-05-30 | 2017-04-18 | Vascular Access Techonlogies, Inc. | Transvascular access methods |
US9364648B2 (en) | 2012-05-30 | 2016-06-14 | Tusker Medical, Inc. | Adhesive earplugs useful for sealing the ear canal |
US9220874B2 (en) | 2012-05-30 | 2015-12-29 | Vascular Access Technologies, Inc. | Transvascular access device and method |
US8961594B2 (en) * | 2012-05-31 | 2015-02-24 | 4Tech Inc. | Heart valve repair system |
US9241707B2 (en) | 2012-05-31 | 2016-01-26 | Abbott Cardiovascular Systems, Inc. | Systems, methods, and devices for closing holes in body lumens |
US9498202B2 (en) | 2012-07-10 | 2016-11-22 | Edwards Lifesciences Corporation | Suture securement devices |
US10016193B2 (en) | 2013-11-18 | 2018-07-10 | Edwards Lifesciences Ag | Multiple-firing crimp device and methods for using and manufacturing same |
WO2014022124A1 (en) | 2012-07-28 | 2014-02-06 | Tendyne Holdings, Inc. | Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly |
US9675454B2 (en) | 2012-07-30 | 2017-06-13 | Tendyne Holdings, Inc. | Delivery systems and methods for transcatheter prosthetic valves |
US10105219B2 (en) | 2012-08-02 | 2018-10-23 | St. Jude Medical, Cardiology Division, Inc. | Mitral valve leaflet clip |
US9254141B2 (en) * | 2012-08-02 | 2016-02-09 | St. Jude Medical, Inc. | Apparatus and method for heart valve repair |
US9125653B2 (en) | 2012-08-02 | 2015-09-08 | St. Jude Medical, Cardiology Division, Inc. | Flexible nosecone for percutaneous device |
US9662205B2 (en) | 2012-08-02 | 2017-05-30 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method for heart valve repair |
US9445899B2 (en) | 2012-08-22 | 2016-09-20 | Joseph M. Arcidi | Method and apparatus for mitral valve annuloplasty |
KR101296604B1 (en) * | 2012-09-05 | 2013-08-14 | 부산대학교 산학협력단 | Sheath and cerclage thread for mitral cerclage annuloplasty |
US20140067048A1 (en) | 2012-09-06 | 2014-03-06 | Edwards Lifesciences Corporation | Heart Valve Sealing Devices |
US9066710B2 (en) | 2012-10-19 | 2015-06-30 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method for heart valve repair |
US9364209B2 (en) | 2012-12-21 | 2016-06-14 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device |
EP2943132B1 (en) | 2013-01-09 | 2018-03-28 | 4Tech Inc. | Soft tissue anchors |
US9439763B2 (en) | 2013-02-04 | 2016-09-13 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US9168129B2 (en) | 2013-02-12 | 2015-10-27 | Edwards Lifesciences Corporation | Artificial heart valve with scalloped frame design |
US9642706B2 (en) | 2013-03-11 | 2017-05-09 | St. Jude Medical, Llc | Apparatus and method for heart valve repair |
US10130808B2 (en) | 2013-03-14 | 2018-11-20 | Tusker Medical, Inc. | System and method for providing iontophoresis at tympanic membrane |
US9681891B2 (en) | 2013-03-14 | 2017-06-20 | Tusker Medical, Inc. | Tympanostomy tube delivery device with cutting dilator |
US9320652B2 (en) | 2013-03-14 | 2016-04-26 | Tusker Medical, Inc. | Features to improve and sense tympanic membrane apposition by tympanostomy tube delivery instrument |
EP2967931B8 (en) | 2013-03-14 | 2017-04-12 | 4Tech Inc. | Stent with tether interface |
US9289297B2 (en) | 2013-03-15 | 2016-03-22 | Cardiosolutions, Inc. | Mitral valve spacer and system and method for implanting the same |
US9744037B2 (en) | 2013-03-15 | 2017-08-29 | California Institute Of Technology | Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves |
US9232998B2 (en) | 2013-03-15 | 2016-01-12 | Cardiosolutions Inc. | Trans-apical implant systems, implants and methods |
US10463489B2 (en) | 2013-04-02 | 2019-11-05 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems and methods for delivering the same |
US11224510B2 (en) | 2013-04-02 | 2022-01-18 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems and methods for delivering the same |
US9486306B2 (en) | 2013-04-02 | 2016-11-08 | Tendyne Holdings, Inc. | Inflatable annular sealing device for prosthetic mitral valve |
US10478293B2 (en) | 2013-04-04 | 2019-11-19 | Tendyne Holdings, Inc. | Retrieval and repositioning system for prosthetic heart valve |
ES2908132T3 (en) | 2013-05-20 | 2022-04-27 | Edwards Lifesciences Corp | Prosthetic Heart Valve Delivery Apparatus |
CN108294846A (en) | 2013-05-20 | 2018-07-20 | 托尔福公司 | Implantable cardiac valve device, mitral valve repair device and related system and method |
KR101611854B1 (en) * | 2013-05-29 | 2016-04-12 | 김준홍 | The punching device and for guiding RVOT wire from coronary sinus to the right centricle in cerclage annuloplasty procedure and guiding method of the RVOT wire using the same |
US9610159B2 (en) | 2013-05-30 | 2017-04-04 | Tendyne Holdings, Inc. | Structural members for prosthetic mitral valves |
JP6731339B2 (en) | 2013-06-14 | 2020-07-29 | カーディオソリューションズ インコーポレイテッドCardiosolutions, Inc. | Mitral valve spacer and implantation system and method thereof |
JP6461122B2 (en) | 2013-06-25 | 2019-01-30 | テンダイン ホールディングス,インコーポレイテッド | Thrombus management and structural compliance features of prosthetic heart valves |
CN105073026B (en) | 2013-07-11 | 2018-02-02 | 爱德华兹生命科学公司 | Without knot suture anchor installation system |
CA2919379C (en) | 2013-08-01 | 2021-03-30 | Tendyne Holdings, Inc. | Epicardial anchor devices and methods |
WO2015028209A1 (en) | 2013-08-30 | 2015-03-05 | Jenavalve Technology Gmbh | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
USD767127S1 (en) * | 2013-10-14 | 2016-09-20 | Tsk Laboratory Europe B.V. | Needle with dome shaped tip |
WO2015058039A1 (en) | 2013-10-17 | 2015-04-23 | Robert Vidlund | Apparatus and methods for alignment and deployment of intracardiac devices |
CN108403261B (en) | 2013-10-28 | 2021-02-12 | 坦迪尼控股股份有限公司 | Prosthetic heart valves and systems and methods for delivering prosthetic heart valves |
US9526611B2 (en) | 2013-10-29 | 2016-12-27 | Tendyne Holdings, Inc. | Apparatus and methods for delivery of transcatheter prosthetic valves |
US10052095B2 (en) | 2013-10-30 | 2018-08-21 | 4Tech Inc. | Multiple anchoring-point tension system |
US10022114B2 (en) | 2013-10-30 | 2018-07-17 | 4Tech Inc. | Percutaneous tether locking |
US9622863B2 (en) | 2013-11-22 | 2017-04-18 | Edwards Lifesciences Corporation | Aortic insufficiency repair device and method |
US10098734B2 (en) | 2013-12-05 | 2018-10-16 | Edwards Lifesciences Corporation | Prosthetic heart valve and delivery apparatus |
WO2015120122A2 (en) | 2014-02-05 | 2015-08-13 | Robert Vidlund | Apparatus and methods for transfemoral delivery of prosthetic mitral valve |
WO2016126942A2 (en) | 2015-02-05 | 2016-08-11 | Vidlund Robert M | Expandable epicardial pads and devices and methods for delivery of same |
US9986993B2 (en) | 2014-02-11 | 2018-06-05 | Tendyne Holdings, Inc. | Adjustable tether and epicardial pad system for prosthetic heart valve |
EP3116409B1 (en) | 2014-03-10 | 2023-07-26 | Tendyne Holdings, Inc. | Devices for positioning and monitoring tether load for prosthetic mitral valve |
US10390943B2 (en) | 2014-03-17 | 2019-08-27 | Evalve, Inc. | Double orifice device for transcatheter mitral valve replacement |
US9572666B2 (en) | 2014-03-17 | 2017-02-21 | Evalve, Inc. | Mitral valve fixation device removal devices and methods |
CA2903891C (en) | 2014-05-30 | 2021-01-19 | Manouchehr A. Miraki | Systems for securing sutures |
US9532870B2 (en) | 2014-06-06 | 2017-01-03 | Edwards Lifesciences Corporation | Prosthetic valve for replacing a mitral valve |
WO2015193728A2 (en) | 2014-06-19 | 2015-12-23 | 4Tech Inc. | Cardiac tissue cinching |
WO2016011275A2 (en) | 2014-07-16 | 2016-01-21 | Edwards Lifesciences Corporation | Devices and methods for suturing a cardiac implant |
US10195026B2 (en) | 2014-07-22 | 2019-02-05 | Edwards Lifesciences Corporation | Mitral valve anchoring |
US20160038341A1 (en) | 2014-08-08 | 2016-02-11 | Acclarent, Inc. | Tympanostomy tube delivery device with elastomeric brake |
US10195086B2 (en) | 2014-08-11 | 2019-02-05 | Tusker Medical, Inc. | Tympanostomy tube delivery device with rotatable |
US9833360B2 (en) | 2014-08-12 | 2017-12-05 | Tusker Medical, Inc. | Tympanostomy tube delivery device with replaceable shaft portion |
US9833359B2 (en) | 2014-08-12 | 2017-12-05 | Tusker Medical, Inc. | Tympanostomy tube delivery device with cutter force clutch |
US10058424B2 (en) | 2014-08-21 | 2018-08-28 | Edwards Lifesciences Corporation | Dual-flange prosthetic valve frame |
EP3284412A1 (en) | 2014-12-02 | 2018-02-21 | 4Tech Inc. | Off-center tissue anchors |
EP3226810A4 (en) | 2014-12-04 | 2018-08-15 | Edwards Lifesciences Corporation | Percutaneous clip for repairing a heart valve |
JP6471341B2 (en) | 2014-12-10 | 2019-02-20 | エドワーズ・ライフサイエンシス・アーゲー | Multi-shot fixing device, method for using a multi-shot fixing device, and method for manufacturing a multi-shot fixing device |
US10188392B2 (en) | 2014-12-19 | 2019-01-29 | Abbott Cardiovascular Systems, Inc. | Grasping for tissue repair |
SG10201901425QA (en) | 2014-12-24 | 2019-03-28 | Edwards Lifesciences Corp | Suture clip deployment devices |
EP3242630A2 (en) | 2015-01-07 | 2017-11-15 | Tendyne Holdings, Inc. | Prosthetic mitral valves and apparatus and methods for delivery of same |
EP3265004B1 (en) | 2015-03-05 | 2023-06-28 | Ancora Heart, Inc. | Devices of visualizing and determining depth of penetration in cardiac tissue |
US10470759B2 (en) | 2015-03-16 | 2019-11-12 | Edwards Lifesciences Corporation | Suture securement devices |
US10524912B2 (en) | 2015-04-02 | 2020-01-07 | Abbott Cardiovascular Systems, Inc. | Tissue fixation devices and methods |
US10010417B2 (en) | 2015-04-16 | 2018-07-03 | Edwards Lifesciences Corporation | Low-profile prosthetic heart valve for replacing a mitral valve |
US10064718B2 (en) | 2015-04-16 | 2018-09-04 | Edwards Lifesciences Corporation | Low-profile prosthetic heart valve for replacing a mitral valve |
CA2983002C (en) | 2015-04-16 | 2023-07-04 | Tendyne Holdings, Inc. | Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves |
US10709555B2 (en) | 2015-05-01 | 2020-07-14 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
WO2016183386A1 (en) | 2015-05-12 | 2016-11-17 | Guided Delivery Systems Inc. | Device and method for releasing catheters from cardiac structures |
US10517726B2 (en) | 2015-05-14 | 2019-12-31 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10376673B2 (en) | 2015-06-19 | 2019-08-13 | Evalve, Inc. | Catheter guiding system and methods |
US10238494B2 (en) | 2015-06-29 | 2019-03-26 | Evalve, Inc. | Self-aligning radiopaque ring |
US10016304B2 (en) | 2015-07-16 | 2018-07-10 | Tusker Medical, Inc. | Earplug assembly for iontophoresis system |
US10667815B2 (en) | 2015-07-21 | 2020-06-02 | Evalve, Inc. | Tissue grasping devices and related methods |
US10413408B2 (en) | 2015-08-06 | 2019-09-17 | Evalve, Inc. | Delivery catheter systems, methods, and devices |
CN107920895B (en) | 2015-08-21 | 2020-06-26 | 托尔福公司 | Implantable heart valve devices, mitral valve repair devices, and associated systems and methods |
US10327894B2 (en) | 2015-09-18 | 2019-06-25 | Tendyne Holdings, Inc. | Methods for delivery of prosthetic mitral valves |
US10765517B2 (en) | 2015-10-01 | 2020-09-08 | Neochord, Inc. | Ringless web for repair of heart valves |
US10238495B2 (en) | 2015-10-09 | 2019-03-26 | Evalve, Inc. | Delivery catheter handle and methods of use |
US10376364B2 (en) | 2015-11-10 | 2019-08-13 | Edwards Lifesciences Corporation | Implant delivery capsule |
US10470876B2 (en) | 2015-11-10 | 2019-11-12 | Edwards Lifesciences Corporation | Transcatheter heart valve for replacing natural mitral valve |
ES2777609T3 (en) | 2015-12-03 | 2020-08-05 | Tendyne Holdings Inc | Framework Features for Prosthetic Mitral Valves |
CN106901784A (en) * | 2015-12-22 | 2017-06-30 | 潘湘斌 | A kind of guiding system and its application method for ultrasound guidance research of transcatheter closure of ventricular septal defect |
WO2017117109A1 (en) | 2015-12-28 | 2017-07-06 | Tendyne Holdings, Inc. | Atrial pocket closures for prosthetic heart valves |
CN108882981B (en) | 2016-01-29 | 2021-08-10 | 内奥瓦斯克迪亚拉公司 | Prosthetic valve for preventing outflow obstruction |
US10687802B2 (en) | 2016-03-02 | 2020-06-23 | Edwards Lifesciences Corporation | Systems and method for deploying surgical suture |
US11219746B2 (en) | 2016-03-21 | 2022-01-11 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10835714B2 (en) | 2016-03-21 | 2020-11-17 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799677B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799676B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799675B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Cam controlled multi-direction steerable handles |
CN109069272A (en) | 2016-04-29 | 2018-12-21 | 美敦力瓦斯科尔勒公司 | Prosthetic heart valve equipment and associated system and method with the anchor log with tether |
US10470877B2 (en) | 2016-05-03 | 2019-11-12 | Tendyne Holdings, Inc. | Apparatus and methods for anterior valve leaflet management |
CN109475419B (en) | 2016-05-13 | 2021-11-09 | 耶拿阀门科技股份有限公司 | Heart valve prosthesis delivery systems and methods for delivering heart valve prostheses through guide sheaths and loading systems |
US11039921B2 (en) | 2016-06-13 | 2021-06-22 | Tendyne Holdings, Inc. | Sequential delivery of two-part prosthetic mitral valve |
CN109640887B (en) | 2016-06-30 | 2021-03-16 | 坦迪尼控股股份有限公司 | Prosthetic heart valve and apparatus and method for delivering same |
US10736632B2 (en) | 2016-07-06 | 2020-08-11 | Evalve, Inc. | Methods and devices for valve clip excision |
US10973638B2 (en) | 2016-07-07 | 2021-04-13 | Edwards Lifesciences Corporation | Device and method for treating vascular insufficiency |
WO2018013515A1 (en) | 2016-07-12 | 2018-01-18 | Tendyne Holdings, Inc. | Apparatus and methods for trans-septal retrieval of prosthetic heart valves |
US10939905B2 (en) | 2016-08-26 | 2021-03-09 | Edwards Lifesciences Corporation | Suture clips, deployment devices therefor, and methods of use |
US11071564B2 (en) | 2016-10-05 | 2021-07-27 | Evalve, Inc. | Cardiac valve cutting device |
US10653862B2 (en) | 2016-11-07 | 2020-05-19 | Edwards Lifesciences Corporation | Apparatus for the introduction and manipulation of multiple telescoping catheters |
US10363138B2 (en) | 2016-11-09 | 2019-07-30 | Evalve, Inc. | Devices for adjusting the curvature of cardiac valve structures |
US10398553B2 (en) | 2016-11-11 | 2019-09-03 | Evalve, Inc. | Opposing disk device for grasping cardiac valve tissue |
US10426616B2 (en) | 2016-11-17 | 2019-10-01 | Evalve, Inc. | Cardiac implant delivery system |
CN116746975A (en) | 2016-11-18 | 2023-09-15 | 复心公司 | Myocardial implant load sharing apparatus and method for promoting LV function |
EP3541462A4 (en) | 2016-11-21 | 2020-06-17 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
US10779837B2 (en) | 2016-12-08 | 2020-09-22 | Evalve, Inc. | Adjustable arm device for grasping tissues |
US10617854B2 (en) | 2016-12-09 | 2020-04-14 | Vascular Access Technologies, Inc. | Trans-jugular carotid artery access methods |
US10314586B2 (en) | 2016-12-13 | 2019-06-11 | Evalve, Inc. | Rotatable device and method for fixing tricuspid valve tissue |
US10863980B2 (en) | 2016-12-28 | 2020-12-15 | Edwards Lifesciences Corporation | Suture fastener having spaced-apart layers |
US10925597B2 (en) | 2016-12-29 | 2021-02-23 | Medtentia International Ltd Oy | Medical securing device for securing an object with a securing member |
EP3342355B1 (en) * | 2016-12-29 | 2020-04-22 | Medtentia International Ltd Oy | Medical securing device for securing an object with a securing member |
US11654224B2 (en) | 2016-12-30 | 2023-05-23 | Vascular Access Technologies, Inc. | Methods and devices for percutaneous implantation of arterio-venous grafts |
US10905554B2 (en) | 2017-01-05 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve coaptation device |
CN110392557A (en) | 2017-01-27 | 2019-10-29 | 耶拿阀门科技股份有限公司 | Heart valve simulation |
US10426449B2 (en) | 2017-02-16 | 2019-10-01 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device with improved actuation and alignment mechanisms |
US10213306B2 (en) * | 2017-03-31 | 2019-02-26 | Neochord, Inc. | Minimally invasive heart valve repair in a beating heart |
US11224511B2 (en) | 2017-04-18 | 2022-01-18 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
US10575950B2 (en) | 2017-04-18 | 2020-03-03 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
US10433961B2 (en) | 2017-04-18 | 2019-10-08 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
ES2906137T3 (en) | 2017-04-18 | 2022-04-13 | Edwards Lifesciences Corp | Heart valve sealing devices and delivery devices therefor |
US10799312B2 (en) | 2017-04-28 | 2020-10-13 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
US10959846B2 (en) | 2017-05-10 | 2021-03-30 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US10792151B2 (en) | 2017-05-11 | 2020-10-06 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
US11065119B2 (en) | 2017-05-12 | 2021-07-20 | Evalve, Inc. | Long arm valve repair clip |
US10646338B2 (en) | 2017-06-02 | 2020-05-12 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
USD836324S1 (en) * | 2017-06-20 | 2018-12-25 | Nestlé Skin Health Sa | Needle tip |
US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
CN111050702B (en) | 2017-07-13 | 2022-07-05 | 坦迪尼控股股份有限公司 | Prosthetic heart valve and apparatus and method for delivering a prosthetic heart valve |
EP3672530A4 (en) | 2017-08-25 | 2021-04-14 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
CN111031967B (en) | 2017-08-28 | 2022-08-09 | 坦迪尼控股股份有限公司 | Prosthetic heart valve with tether connection features |
US11051940B2 (en) | 2017-09-07 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic spacer device for heart valve |
US11065117B2 (en) | 2017-09-08 | 2021-07-20 | Edwards Lifesciences Corporation | Axisymmetric adjustable device for treating mitral regurgitation |
US11040174B2 (en) | 2017-09-19 | 2021-06-22 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10111751B1 (en) | 2018-01-09 | 2018-10-30 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10231837B1 (en) | 2018-01-09 | 2019-03-19 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10076415B1 (en) | 2018-01-09 | 2018-09-18 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10105222B1 (en) | 2018-01-09 | 2018-10-23 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10136993B1 (en) | 2018-01-09 | 2018-11-27 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10159570B1 (en) | 2018-01-09 | 2018-12-25 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
EP3964175A1 (en) | 2018-01-09 | 2022-03-09 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10123873B1 (en) | 2018-01-09 | 2018-11-13 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10973639B2 (en) | 2018-01-09 | 2021-04-13 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10238493B1 (en) | 2018-01-09 | 2019-03-26 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10245144B1 (en) | 2018-01-09 | 2019-04-02 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
JP7083549B2 (en) | 2018-03-23 | 2022-06-13 | ネオコード インコーポレイテッド | Suture attachment device for minimally invasive heart valve repair |
US10660637B2 (en) * | 2018-04-06 | 2020-05-26 | Cypris Medical, Inc. | Suturing system |
US11389297B2 (en) | 2018-04-12 | 2022-07-19 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US11207181B2 (en) | 2018-04-18 | 2021-12-28 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11253360B2 (en) | 2018-05-09 | 2022-02-22 | Neochord, Inc. | Low profile tissue anchor for minimally invasive heart valve repair |
US11173030B2 (en) | 2018-05-09 | 2021-11-16 | Neochord, Inc. | Suture length adjustment for minimally invasive heart valve repair |
US11134937B2 (en) | 2018-07-02 | 2021-10-05 | Edwards Lifesciences Corporation | Suture clip |
CA3112020C (en) | 2018-09-07 | 2023-10-03 | Neochord, Inc. | Device for suture attachment for minimally invasive heart valve repair |
US10945844B2 (en) | 2018-10-10 | 2021-03-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
JP7260930B2 (en) | 2018-11-08 | 2023-04-19 | ニオバスク ティアラ インコーポレイテッド | Ventricular deployment of a transcatheter mitral valve prosthesis |
CN114206264A (en) | 2019-02-14 | 2022-03-18 | 爱德华兹生命科学公司 | Heart valve sealing device and delivery device thereof |
AU2020233892A1 (en) | 2019-03-08 | 2021-11-04 | Neovasc Tiara Inc. | Retrievable prosthesis delivery system |
EP3946163A4 (en) | 2019-04-01 | 2022-12-21 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
CN113924065A (en) | 2019-04-10 | 2022-01-11 | 内奥瓦斯克迪亚拉公司 | Prosthetic valve with natural blood flow |
EP3955855A4 (en) | 2019-04-16 | 2023-01-25 | NeoChord, Inc. | Transverse helical cardiac anchor for minimally invasive heart valve repair |
US20200338324A1 (en) * | 2019-04-23 | 2020-10-29 | Merit Medical Systems, Inc. | Drainage catheter with suture lumen |
WO2020257643A1 (en) | 2019-06-20 | 2020-12-24 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
WO2021011659A1 (en) * | 2019-07-15 | 2021-01-21 | Ancora Heart, Inc. | Devices and methods for tether cutting |
CN112294376B (en) * | 2019-08-29 | 2021-12-28 | 杭州德晋医疗科技有限公司 | A long-range suture locking device of staple and intervention formula for locking suture |
EP3831343B1 (en) | 2019-12-05 | 2024-01-31 | Tendyne Holdings, Inc. | Braided anchor for mitral valve |
US11648114B2 (en) | 2019-12-20 | 2023-05-16 | Tendyne Holdings, Inc. | Distally loaded sheath and loading funnel |
US11951002B2 (en) | 2020-03-30 | 2024-04-09 | Tendyne Holdings, Inc. | Apparatus and methods for valve and tether fixation |
EP4199860A1 (en) | 2020-08-19 | 2023-06-28 | Tendyne Holdings, Inc. | Fully-transseptal apical pad with pulley for tensioning |
CN117098502A (en) * | 2021-01-21 | 2023-11-21 | 尼奥绰德有限公司 | Minimally invasive heart valve repair in beating heart |
Citations (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3769980A (en) * | 1971-06-28 | 1973-11-06 | Medical Concepts Inc | Medical instruments |
US3805793A (en) * | 1973-03-21 | 1974-04-23 | S Wright | Anastomotic apparatus |
US4350160A (en) * | 1979-11-14 | 1982-09-21 | Kolesov Evgeny V | Instrument for establishing vascular anastomoses |
US5080663A (en) * | 1990-09-26 | 1992-01-14 | Univerity College London | Sewing device |
US5242456A (en) * | 1991-11-21 | 1993-09-07 | Kensey Nash Corporation | Apparatus and methods for clamping tissue and reflecting the same |
US5267958A (en) * | 1992-03-30 | 1993-12-07 | Medtronic, Inc. | Exchange catheter having exterior guide wire loops |
US5330442A (en) * | 1992-10-09 | 1994-07-19 | United States Surgical Corporation | Suture retaining clip |
US5374275A (en) * | 1993-03-25 | 1994-12-20 | Synvasive Technology, Inc. | Surgical suturing device and method of use |
US5403326A (en) * | 1993-02-01 | 1995-04-04 | The Regents Of The University Of California | Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux |
US5431666A (en) * | 1994-02-24 | 1995-07-11 | Lasersurge, Inc. | Surgical suture instrument |
US5443446A (en) * | 1991-04-04 | 1995-08-22 | Shturman Cardiology Systems, Inc. | Method and apparatus for in vivo heart valve decalcification |
US5458131A (en) * | 1992-08-25 | 1995-10-17 | Wilk; Peter J. | Method for use in intra-abdominal surgery |
US5474573A (en) * | 1994-08-22 | 1995-12-12 | Hatcher; Charles W. | Toggle suture handling means and method |
US5540704A (en) * | 1992-09-04 | 1996-07-30 | Laurus Medical Corporation | Endoscopic suture system |
US5569274A (en) * | 1993-02-22 | 1996-10-29 | Heartport, Inc. | Endoscopic vascular clamping system and method |
US5573540A (en) * | 1994-07-18 | 1996-11-12 | Yoon; Inbae | Apparatus and method for suturing an opening in anatomical tissue |
US5575800A (en) * | 1992-09-04 | 1996-11-19 | Laurus Medical Corporation | Endoscopic suture system |
US5578044A (en) * | 1992-09-04 | 1996-11-26 | Laurus Medical Corporation | Endoscopic suture system |
US5601574A (en) * | 1992-09-14 | 1997-02-11 | Ethicon, Inc. | Sterile clips and instrument for their placement |
US5609598A (en) * | 1994-12-30 | 1997-03-11 | Vnus Medical Technologies, Inc. | Method and apparatus for minimally invasive treatment of chronic venous insufficiency |
US5643289A (en) * | 1994-02-24 | 1997-07-01 | Lasersurge, Inc. | Surgical crimping device and method of use |
US5685867A (en) * | 1990-01-08 | 1997-11-11 | The Curators Of The University Of Missouri | Clot resistant multiple lumen catheter |
US5695457A (en) * | 1994-07-28 | 1997-12-09 | Heartport, Inc. | Cardioplegia catheter system |
US5713911A (en) * | 1996-10-03 | 1998-02-03 | United States Surgical Corporation | Surgical clip |
US5713910A (en) * | 1992-09-04 | 1998-02-03 | Laurus Medical Corporation | Needle guidance system for endoscopic suture device |
US5716367A (en) * | 1995-10-18 | 1998-02-10 | Nissho Corporation | Catheter assembly for intracardiac suture |
US5766183A (en) * | 1996-10-21 | 1998-06-16 | Lasersurge, Inc. | Vascular hole closure |
US5792094A (en) * | 1991-07-16 | 1998-08-11 | Heartport, Inc. | Method of delivering cardioplegic fluid to a patient's heart |
US5792153A (en) * | 1994-03-23 | 1998-08-11 | University College London | Sewing device |
US5814097A (en) * | 1992-12-03 | 1998-09-29 | Heartport, Inc. | Devices and methods for intracardiac procedures |
US5836956A (en) * | 1995-07-14 | 1998-11-17 | C.R. Bard, Inc. | Wound closure apparatus and method |
US5839639A (en) * | 1995-08-17 | 1998-11-24 | Lasersurge, Inc. | Collapsible anvil assembly and applicator instrument |
US5849019A (en) * | 1995-03-09 | 1998-12-15 | Yoon; Inbae | Multifunctional spring clips and cartridges and applications therefor |
US5860992A (en) * | 1996-01-31 | 1999-01-19 | Heartport, Inc. | Endoscopic suturing devices and methods |
US5891160A (en) * | 1996-02-23 | 1999-04-06 | Cardiovascular Technologies, Llc | Fastener delivery and deployment mechanism and method for placing the fastener in minimally invasive surgery |
US5891159A (en) * | 1997-05-02 | 1999-04-06 | Cardiothoratic Systems, Inc. | Automatic purse string suture device |
US5924424A (en) * | 1993-02-22 | 1999-07-20 | Heartport, Inc. | Method and apparatus for thoracoscopic intracardiac procedures |
US5928250A (en) * | 1997-01-30 | 1999-07-27 | Nissho Corporation | Catheter assembly for intracardiac suture |
US5928224A (en) * | 1997-01-24 | 1999-07-27 | Hearten Medical, Inc. | Device for the treatment of damaged heart valve leaflets and methods of using the device |
US5968059A (en) * | 1997-03-06 | 1999-10-19 | Scimed Life Systems, Inc. | Transmyocardial revascularization catheter and method |
US5972020A (en) * | 1997-02-14 | 1999-10-26 | Cardiothoracic Systems, Inc. | Surgical instrument for cardiac valve repair on the beating heart |
US5976159A (en) * | 1995-02-24 | 1999-11-02 | Heartport, Inc. | Surgical clips and methods for tissue approximation |
US6004310A (en) * | 1998-06-17 | 1999-12-21 | Target Therapeutics, Inc. | Multilumen catheter shaft with reinforcement |
US6010531A (en) * | 1993-02-22 | 2000-01-04 | Heartport, Inc. | Less-invasive devices and methods for cardiac valve surgery |
US6015417A (en) * | 1996-01-25 | 2000-01-18 | Reynolds, Jr.; Walker | Surgical fastener |
US6015427A (en) * | 1997-07-07 | 2000-01-18 | Eclipse Surgical Technologies, Inc. | Heart stabilizer with controllable stay suture and cutting element |
US6029671A (en) * | 1991-07-16 | 2000-02-29 | Heartport, Inc. | System and methods for performing endovascular procedures |
US6047700A (en) * | 1998-03-30 | 2000-04-11 | Arthrocare Corporation | Systems and methods for electrosurgical removal of calcified deposits |
US6056760A (en) * | 1997-01-30 | 2000-05-02 | Nissho Corporation | Device for intracardiac suture |
US6080182A (en) * | 1996-12-20 | 2000-06-27 | Gore Enterprise Holdings, Inc. | Self-expanding defect closure device and method of making and using |
US6088889A (en) * | 1997-09-03 | 2000-07-18 | Edward Elson | Clamp operable as a hemostasis valve |
US6117159A (en) * | 1996-03-22 | 2000-09-12 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US6136010A (en) * | 1999-03-04 | 2000-10-24 | Perclose, Inc. | Articulating suturing device and method |
US6149660A (en) * | 1996-04-22 | 2000-11-21 | Vnus Medical Technologies, Inc. | Method and apparatus for delivery of an appliance in a vessel |
US6157852A (en) * | 1998-01-15 | 2000-12-05 | Lumend, Inc. | Catheter apparatus for treating arterial occlusions |
US6162233A (en) * | 1996-02-23 | 2000-12-19 | Cardiovascular Technologies, Llc | Wire fasteners for use in minimally invasive surgery and means and methods for handling those fasteners |
US6165204A (en) * | 1999-06-11 | 2000-12-26 | Scion International, Inc. | Shaped suture clip, appliance and method therefor |
US6165183A (en) * | 1998-07-15 | 2000-12-26 | St. Jude Medical, Inc. | Mitral and tricuspid valve repair |
US6190357B1 (en) * | 1998-04-21 | 2001-02-20 | Cardiothoracic Systems, Inc. | Expandable cannula for performing cardiopulmonary bypass and method for using same |
US6210419B1 (en) * | 1998-12-18 | 2001-04-03 | Aesculap Ag & Co. Kg | Surgical clip |
US6234995B1 (en) * | 1998-11-12 | 2001-05-22 | Advanced Interventional Technologies, Inc. | Apparatus and method for selectively isolating a proximal anastomosis site from blood in an aorta |
US6269819B1 (en) * | 1997-06-27 | 2001-08-07 | The Trustees Of Columbia University In The City Of New York | Method and apparatus for circulatory valve repair |
US6312447B1 (en) * | 1999-10-13 | 2001-11-06 | The General Hospital Corporation | Devices and methods for percutaneous mitral valve repair |
US20020049402A1 (en) * | 1997-11-21 | 2002-04-25 | Peacock James C. | Endolumenal aortic isolation assembly and method |
US20020107531A1 (en) * | 2001-02-06 | 2002-08-08 | Schreck Stefan G. | Method and system for tissue repair using dual catheters |
US20020107530A1 (en) * | 2001-02-02 | 2002-08-08 | Sauer Jude S. | System for endoscopic suturing |
US6443922B1 (en) * | 1997-01-24 | 2002-09-03 | Heartport, Inc. | Methods and devices for maintaining cardiopulmonary bypass and arresting a patient's heart |
US6461366B1 (en) * | 1997-09-12 | 2002-10-08 | Evalve, Inc. | Surgical device for connecting soft tissue |
US20020188321A1 (en) * | 2001-04-12 | 2002-12-12 | Scion International, Inc. | Suture lock, lock applicator and method therefor |
US6508777B1 (en) * | 1998-05-08 | 2003-01-21 | Cardeon Corporation | Circulatory support system and method of use for isolated segmental perfusion |
US6575971B2 (en) * | 2001-11-15 | 2003-06-10 | Quantum Cor, Inc. | Cardiac valve leaflet stapler device and methods thereof |
US6582388B1 (en) * | 1997-11-21 | 2003-06-24 | Advanced Interventional Technologies, Inc. | Cardiac bypass catheter system and method of use |
US20030130571A1 (en) * | 2001-12-08 | 2003-07-10 | Lattouf Omar M. | Treatment for patient with congestive heart failure |
US20030167062A1 (en) * | 2003-03-13 | 2003-09-04 | Gambale Richard A | Suture clips,delivery devices and methods |
US6626930B1 (en) * | 1999-10-21 | 2003-09-30 | Edwards Lifesciences Corporation | Minimally invasive mitral valve repair method and apparatus |
US6629534B1 (en) * | 1999-04-09 | 2003-10-07 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US6645205B2 (en) * | 2001-08-15 | 2003-11-11 | Core Medical, Inc. | Apparatus and methods for reducing lung volume |
US6652562B2 (en) * | 2001-12-28 | 2003-11-25 | Ethicon, Inc. | Suture anchoring and tensioning device |
US20040044365A1 (en) * | 2002-09-03 | 2004-03-04 | Bachman Alan B. | Single catheter mitral valve repair device and method for use |
US6752813B2 (en) * | 1999-04-09 | 2004-06-22 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4055167A (en) | 1976-04-23 | 1977-10-25 | Bernstein Dell L | Curettement device |
US4311140A (en) | 1976-05-10 | 1982-01-19 | Henry Bridgman | Vacuum curet having an improved curetting opening |
US5269809A (en) * | 1990-07-02 | 1993-12-14 | American Cyanamid Company | Locking mechanism for use with a slotted suture anchor |
US5258015A (en) * | 1991-05-03 | 1993-11-02 | American Cyanamid Company | Locking filament caps |
US5571215A (en) | 1993-02-22 | 1996-11-05 | Heartport, Inc. | Devices and methods for intracardiac procedures |
US5344059A (en) | 1992-05-19 | 1994-09-06 | United States Surgical Corporation | Surgical apparatus and anvil delivery system therefor |
US5312423A (en) * | 1992-10-01 | 1994-05-17 | Advanced Surgical Intervention, Inc. | Apparatus and method for laparaoscopic ligation |
ES2129803T3 (en) | 1993-12-22 | 1999-06-16 | Sulzer Osypka Gmbh | ULTRASONICALLY MARKED CARDIAC ABLATION CATHETER. |
US5601576A (en) | 1994-08-10 | 1997-02-11 | Heartport Inc. | Surgical knot pusher and method of use |
JP3587571B2 (en) * | 1994-11-21 | 2004-11-10 | オリンパス株式会社 | Medical suture device |
US5695504A (en) | 1995-02-24 | 1997-12-09 | Heartport, Inc. | Devices and methods for performing a vascular anastomosis |
US5669935A (en) * | 1995-07-28 | 1997-09-23 | Ethicon, Inc. | One-way suture retaining device for braided sutures |
AU733332B2 (en) | 1996-02-02 | 2001-05-10 | Transvascular, Inc. | Methods and apparatus for blocking flow through blood vessels |
JP2001502190A (en) * | 1996-02-22 | 2001-02-20 | スミス アンド ネフュー インコーポレーテッド | Suture collet |
US5993466A (en) | 1997-06-17 | 1999-11-30 | Yoon; Inbae | Suturing instrument with multiple rotatably mounted spreadable needle holders |
DE19725739C1 (en) | 1997-06-18 | 1999-04-15 | Aesculap Ag & Co Kg | Instrument for applying clips to tubular organs |
AU9669898A (en) | 1997-09-26 | 1999-04-12 | Cardeon Corporation | Multi-function aortic catheterization and bumper instrument |
US6099552A (en) * | 1997-11-12 | 2000-08-08 | Boston Scientific Corporation | Gastrointestinal copression clips |
JP4125814B2 (en) | 1998-03-04 | 2008-07-30 | Hoya株式会社 | Ultrasound endoscope |
US6599311B1 (en) * | 1998-06-05 | 2003-07-29 | Broncus Technologies, Inc. | Method and assembly for lung volume reduction |
US7569062B1 (en) | 1998-07-15 | 2009-08-04 | St. Jude Medical, Inc. | Mitral and tricuspid valve repair |
AU4055700A (en) | 1999-04-01 | 2000-10-23 | David B. Bjerken | Vacuum-assisted remote suture placement system |
US6299622B1 (en) | 1999-08-19 | 2001-10-09 | Fox Hollow Technologies, Inc. | Atherectomy catheter with aligned imager |
US6641592B1 (en) | 1999-11-19 | 2003-11-04 | Lsi Solutions, Inc. | System for wound closure |
WO2001066018A1 (en) | 2000-03-03 | 2001-09-13 | C. R. Bard, Inc. | Endoscopic tissue apposition device with multiple suction ports |
EP1263330B1 (en) * | 2000-03-03 | 2014-06-18 | C.R. Bard, Inc. | Suture clip delivery device |
JP2004520853A (en) * | 2000-05-19 | 2004-07-15 | シー・アール・バード・インク | Tissue capture suturing device and method |
EP1303218A1 (en) | 2000-06-14 | 2003-04-23 | Sterilis, Inc. | Suturing method and apparatus |
US6551330B1 (en) | 2000-09-21 | 2003-04-22 | Opus Medical, Inc. | Linear suturing apparatus and methods |
US6860890B2 (en) | 2001-03-02 | 2005-03-01 | Edwards Lifesciences Corporation | Surgical knot pushing device and method of use |
US6629543B2 (en) * | 2001-08-03 | 2003-10-07 | Siemens Automotive Corporation | Fuel system including a self-contained flow-through pressure regulator |
US7048754B2 (en) | 2002-03-01 | 2006-05-23 | Evalve, Inc. | Suture fasteners and methods of use |
US7094244B2 (en) | 2002-03-26 | 2006-08-22 | Edwards Lifesciences Corporation | Sequential heart valve leaflet repair device and method of use |
US20030195524A1 (en) | 2002-04-12 | 2003-10-16 | Gil Barner | Body tissue aspiration cannula |
IL150151A (en) | 2002-06-11 | 2010-11-30 | Mim Minimally Invasive Mastopexy Ltd | System for breast lifting |
US7381210B2 (en) * | 2003-03-14 | 2008-06-03 | Edwards Lifesciences Corporation | Mitral valve repair system and method for use |
US8388653B2 (en) | 2004-05-14 | 2013-03-05 | Ethicon Endo-Surgery, Inc. | T-type suture anchoring devices and methods of using same |
US8252005B2 (en) * | 2005-06-30 | 2012-08-28 | Edwards Lifesciences Corporation | System, apparatus, and method for fastening tissue |
-
2003
- 2003-03-14 US US10/389,721 patent/US7381210B2/en active Active
-
2004
- 2004-03-11 CA CA2518962A patent/CA2518962C/en not_active Expired - Fee Related
- 2004-03-11 JP JP2006507062A patent/JP4558718B2/en not_active Expired - Lifetime
- 2004-03-11 CA CA2754649A patent/CA2754649C/en not_active Expired - Fee Related
- 2004-03-11 EP EP04719723A patent/EP1605833A2/en not_active Withdrawn
- 2004-03-11 WO PCT/US2004/007383 patent/WO2004082523A2/en active Application Filing
- 2004-03-11 AU AU2004222384A patent/AU2004222384A1/en not_active Abandoned
- 2004-03-11 EP EP11182951.1A patent/EP2401970B1/en not_active Expired - Lifetime
-
2008
- 2008-05-29 US US12/129,574 patent/US20080228201A1/en not_active Abandoned
-
2009
- 2009-09-02 US US12/552,972 patent/US8226666B2/en not_active Expired - Lifetime
-
2012
- 2012-07-23 US US13/556,039 patent/US8777991B2/en not_active Expired - Lifetime
Patent Citations (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3769980A (en) * | 1971-06-28 | 1973-11-06 | Medical Concepts Inc | Medical instruments |
US3805793A (en) * | 1973-03-21 | 1974-04-23 | S Wright | Anastomotic apparatus |
US4350160A (en) * | 1979-11-14 | 1982-09-21 | Kolesov Evgeny V | Instrument for establishing vascular anastomoses |
US5685867A (en) * | 1990-01-08 | 1997-11-11 | The Curators Of The University Of Missouri | Clot resistant multiple lumen catheter |
US5080663A (en) * | 1990-09-26 | 1992-01-14 | Univerity College London | Sewing device |
US5443446A (en) * | 1991-04-04 | 1995-08-22 | Shturman Cardiology Systems, Inc. | Method and apparatus for in vivo heart valve decalcification |
US6029671A (en) * | 1991-07-16 | 2000-02-29 | Heartport, Inc. | System and methods for performing endovascular procedures |
US5792094A (en) * | 1991-07-16 | 1998-08-11 | Heartport, Inc. | Method of delivering cardioplegic fluid to a patient's heart |
US5885238A (en) * | 1991-07-16 | 1999-03-23 | Heartport, Inc. | System for cardiac procedures |
US5242456A (en) * | 1991-11-21 | 1993-09-07 | Kensey Nash Corporation | Apparatus and methods for clamping tissue and reflecting the same |
US5267958A (en) * | 1992-03-30 | 1993-12-07 | Medtronic, Inc. | Exchange catheter having exterior guide wire loops |
US5458131A (en) * | 1992-08-25 | 1995-10-17 | Wilk; Peter J. | Method for use in intra-abdominal surgery |
US5713910A (en) * | 1992-09-04 | 1998-02-03 | Laurus Medical Corporation | Needle guidance system for endoscopic suture device |
US5540704A (en) * | 1992-09-04 | 1996-07-30 | Laurus Medical Corporation | Endoscopic suture system |
US5741279A (en) * | 1992-09-04 | 1998-04-21 | Laurus Medical Corporation | Endoscopic suture system |
US5662664A (en) * | 1992-09-04 | 1997-09-02 | Laurus Medical Corporation | Endoscopic suture system |
US5575800A (en) * | 1992-09-04 | 1996-11-19 | Laurus Medical Corporation | Endoscopic suture system |
US5578044A (en) * | 1992-09-04 | 1996-11-26 | Laurus Medical Corporation | Endoscopic suture system |
US5700272A (en) * | 1992-09-04 | 1997-12-23 | Laurus Medical Corporation | Endoscopic suture system |
US5741277A (en) * | 1992-09-04 | 1998-04-21 | Laurus Medical Corporation | Endoscopic suture system |
US5601574A (en) * | 1992-09-14 | 1997-02-11 | Ethicon, Inc. | Sterile clips and instrument for their placement |
US5330442A (en) * | 1992-10-09 | 1994-07-19 | United States Surgical Corporation | Suture retaining clip |
US5814097A (en) * | 1992-12-03 | 1998-09-29 | Heartport, Inc. | Devices and methods for intracardiac procedures |
US5403326A (en) * | 1993-02-01 | 1995-04-04 | The Regents Of The University Of California | Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux |
US5569274A (en) * | 1993-02-22 | 1996-10-29 | Heartport, Inc. | Endoscopic vascular clamping system and method |
US5924424A (en) * | 1993-02-22 | 1999-07-20 | Heartport, Inc. | Method and apparatus for thoracoscopic intracardiac procedures |
US6010531A (en) * | 1993-02-22 | 2000-01-04 | Heartport, Inc. | Less-invasive devices and methods for cardiac valve surgery |
US5374275A (en) * | 1993-03-25 | 1994-12-20 | Synvasive Technology, Inc. | Surgical suturing device and method of use |
US5643289A (en) * | 1994-02-24 | 1997-07-01 | Lasersurge, Inc. | Surgical crimping device and method of use |
US5431666A (en) * | 1994-02-24 | 1995-07-11 | Lasersurge, Inc. | Surgical suture instrument |
US5792153A (en) * | 1994-03-23 | 1998-08-11 | University College London | Sewing device |
US5573540A (en) * | 1994-07-18 | 1996-11-12 | Yoon; Inbae | Apparatus and method for suturing an opening in anatomical tissue |
US5695457A (en) * | 1994-07-28 | 1997-12-09 | Heartport, Inc. | Cardioplegia catheter system |
US5474573A (en) * | 1994-08-22 | 1995-12-12 | Hatcher; Charles W. | Toggle suture handling means and method |
US5609598A (en) * | 1994-12-30 | 1997-03-11 | Vnus Medical Technologies, Inc. | Method and apparatus for minimally invasive treatment of chronic venous insufficiency |
US5810847A (en) * | 1994-12-30 | 1998-09-22 | Vnus Medical Technologies, Inc. | Method and apparatus for minimally invasive treatment of chronic venous insufficiency |
US5976159A (en) * | 1995-02-24 | 1999-11-02 | Heartport, Inc. | Surgical clips and methods for tissue approximation |
US5849019A (en) * | 1995-03-09 | 1998-12-15 | Yoon; Inbae | Multifunctional spring clips and cartridges and applications therefor |
US5836956A (en) * | 1995-07-14 | 1998-11-17 | C.R. Bard, Inc. | Wound closure apparatus and method |
US5839639A (en) * | 1995-08-17 | 1998-11-24 | Lasersurge, Inc. | Collapsible anvil assembly and applicator instrument |
US5716367A (en) * | 1995-10-18 | 1998-02-10 | Nissho Corporation | Catheter assembly for intracardiac suture |
US6015417A (en) * | 1996-01-25 | 2000-01-18 | Reynolds, Jr.; Walker | Surgical fastener |
US5860992A (en) * | 1996-01-31 | 1999-01-19 | Heartport, Inc. | Endoscopic suturing devices and methods |
US5891160A (en) * | 1996-02-23 | 1999-04-06 | Cardiovascular Technologies, Llc | Fastener delivery and deployment mechanism and method for placing the fastener in minimally invasive surgery |
US6162233A (en) * | 1996-02-23 | 2000-12-19 | Cardiovascular Technologies, Llc | Wire fasteners for use in minimally invasive surgery and means and methods for handling those fasteners |
US6117159A (en) * | 1996-03-22 | 2000-09-12 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US6149660A (en) * | 1996-04-22 | 2000-11-21 | Vnus Medical Technologies, Inc. | Method and apparatus for delivery of an appliance in a vessel |
US5713911A (en) * | 1996-10-03 | 1998-02-03 | United States Surgical Corporation | Surgical clip |
US5766183A (en) * | 1996-10-21 | 1998-06-16 | Lasersurge, Inc. | Vascular hole closure |
US6080182A (en) * | 1996-12-20 | 2000-06-27 | Gore Enterprise Holdings, Inc. | Self-expanding defect closure device and method of making and using |
US6443922B1 (en) * | 1997-01-24 | 2002-09-03 | Heartport, Inc. | Methods and devices for maintaining cardiopulmonary bypass and arresting a patient's heart |
US5928224A (en) * | 1997-01-24 | 1999-07-27 | Hearten Medical, Inc. | Device for the treatment of damaged heart valve leaflets and methods of using the device |
US6083219A (en) * | 1997-01-24 | 2000-07-04 | Laufer; Michael D. | Device for the treatment of damaged heart value leaflets and method of using the device |
US5928250A (en) * | 1997-01-30 | 1999-07-27 | Nissho Corporation | Catheter assembly for intracardiac suture |
US6056760A (en) * | 1997-01-30 | 2000-05-02 | Nissho Corporation | Device for intracardiac suture |
US5972020A (en) * | 1997-02-14 | 1999-10-26 | Cardiothoracic Systems, Inc. | Surgical instrument for cardiac valve repair on the beating heart |
US5968059A (en) * | 1997-03-06 | 1999-10-19 | Scimed Life Systems, Inc. | Transmyocardial revascularization catheter and method |
US5891159A (en) * | 1997-05-02 | 1999-04-06 | Cardiothoratic Systems, Inc. | Automatic purse string suture device |
US6269819B1 (en) * | 1997-06-27 | 2001-08-07 | The Trustees Of Columbia University In The City Of New York | Method and apparatus for circulatory valve repair |
US6015427A (en) * | 1997-07-07 | 2000-01-18 | Eclipse Surgical Technologies, Inc. | Heart stabilizer with controllable stay suture and cutting element |
US6088889A (en) * | 1997-09-03 | 2000-07-18 | Edward Elson | Clamp operable as a hemostasis valve |
US6770083B2 (en) * | 1997-09-12 | 2004-08-03 | Evalve, Inc. | Surgical device for connecting soft tissue |
US6461366B1 (en) * | 1997-09-12 | 2002-10-08 | Evalve, Inc. | Surgical device for connecting soft tissue |
US20020049402A1 (en) * | 1997-11-21 | 2002-04-25 | Peacock James C. | Endolumenal aortic isolation assembly and method |
US6582388B1 (en) * | 1997-11-21 | 2003-06-24 | Advanced Interventional Technologies, Inc. | Cardiac bypass catheter system and method of use |
US6157852A (en) * | 1998-01-15 | 2000-12-05 | Lumend, Inc. | Catheter apparatus for treating arterial occlusions |
US6047700A (en) * | 1998-03-30 | 2000-04-11 | Arthrocare Corporation | Systems and methods for electrosurgical removal of calcified deposits |
US6190357B1 (en) * | 1998-04-21 | 2001-02-20 | Cardiothoracic Systems, Inc. | Expandable cannula for performing cardiopulmonary bypass and method for using same |
US6508777B1 (en) * | 1998-05-08 | 2003-01-21 | Cardeon Corporation | Circulatory support system and method of use for isolated segmental perfusion |
US6004310A (en) * | 1998-06-17 | 1999-12-21 | Target Therapeutics, Inc. | Multilumen catheter shaft with reinforcement |
US6165183A (en) * | 1998-07-15 | 2000-12-26 | St. Jude Medical, Inc. | Mitral and tricuspid valve repair |
US6234995B1 (en) * | 1998-11-12 | 2001-05-22 | Advanced Interventional Technologies, Inc. | Apparatus and method for selectively isolating a proximal anastomosis site from blood in an aorta |
US6210419B1 (en) * | 1998-12-18 | 2001-04-03 | Aesculap Ag & Co. Kg | Surgical clip |
US6136010A (en) * | 1999-03-04 | 2000-10-24 | Perclose, Inc. | Articulating suturing device and method |
US6629534B1 (en) * | 1999-04-09 | 2003-10-07 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US6752813B2 (en) * | 1999-04-09 | 2004-06-22 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US6165204A (en) * | 1999-06-11 | 2000-12-26 | Scion International, Inc. | Shaped suture clip, appliance and method therefor |
US6875224B2 (en) * | 1999-10-13 | 2005-04-05 | Massachusetts General Hospital | Devices and methods for percutaneous mitral valve repair |
US6312447B1 (en) * | 1999-10-13 | 2001-11-06 | The General Hospital Corporation | Devices and methods for percutaneous mitral valve repair |
US6626930B1 (en) * | 1999-10-21 | 2003-09-30 | Edwards Lifesciences Corporation | Minimally invasive mitral valve repair method and apparatus |
US20020107530A1 (en) * | 2001-02-02 | 2002-08-08 | Sauer Jude S. | System for endoscopic suturing |
US20020107531A1 (en) * | 2001-02-06 | 2002-08-08 | Schreck Stefan G. | Method and system for tissue repair using dual catheters |
US20020188321A1 (en) * | 2001-04-12 | 2002-12-12 | Scion International, Inc. | Suture lock, lock applicator and method therefor |
US6645205B2 (en) * | 2001-08-15 | 2003-11-11 | Core Medical, Inc. | Apparatus and methods for reducing lung volume |
US6575971B2 (en) * | 2001-11-15 | 2003-06-10 | Quantum Cor, Inc. | Cardiac valve leaflet stapler device and methods thereof |
US20030130571A1 (en) * | 2001-12-08 | 2003-07-10 | Lattouf Omar M. | Treatment for patient with congestive heart failure |
US6652562B2 (en) * | 2001-12-28 | 2003-11-25 | Ethicon, Inc. | Suture anchoring and tensioning device |
US20040044365A1 (en) * | 2002-09-03 | 2004-03-04 | Bachman Alan B. | Single catheter mitral valve repair device and method for use |
US7083628B2 (en) * | 2002-09-03 | 2006-08-01 | Edwards Lifesciences Corporation | Single catheter mitral valve repair device and method for use |
US20030167062A1 (en) * | 2003-03-13 | 2003-09-04 | Gambale Richard A | Suture clips,delivery devices and methods |
Cited By (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10194902B2 (en) | 1999-07-02 | 2019-02-05 | Quickpass, Inc. | Suturing device |
US9398907B2 (en) | 1999-07-02 | 2016-07-26 | Quickpass, Inc. | Suturing device |
US11744576B2 (en) | 2005-06-20 | 2023-09-05 | Scarab Technology Services, Llc | Method and apparatus for applying a knot to a suture |
US10758223B2 (en) | 2005-06-20 | 2020-09-01 | Scarab Technology Services, Llc | Method and apparatus for applying a knot to a suture |
US9642616B2 (en) | 2005-06-20 | 2017-05-09 | Nobles Medical Technologies, Inc. | Method and apparatus for applying a knot to a suture |
US10182802B2 (en) | 2007-03-29 | 2019-01-22 | Nobles Medical Technologies, Inc. | Suturing devices and methods for closing a patent foramen ovale |
US9131938B2 (en) | 2007-03-29 | 2015-09-15 | Nobles Medical Technologies, Inc. | Suturing devices and methods for closing a patent foramen ovale |
US11197661B2 (en) | 2007-03-29 | 2021-12-14 | Scarab Technology Services, Llc | Device for applying a knot to a suture |
US9326764B2 (en) | 2008-05-09 | 2016-05-03 | Nobles Medical Technologies Inc. | Suturing devices and methods for suturing an anatomic valve |
US10285687B2 (en) | 2008-05-09 | 2019-05-14 | Nobles Medical Technologies Inc. | Suturing devices and methods for suturing an anatomic valve |
US11166712B2 (en) | 2008-05-09 | 2021-11-09 | Scarab Technology Services, Llc | Suturing devices and methods for suturing an anatomic valve |
KR101116867B1 (en) | 2009-08-28 | 2012-03-06 | 김준홍 | The device for delivering optimal tension safaely and effectively in cerclage annuloplasty procedure |
US10195032B2 (en) | 2009-08-28 | 2019-02-05 | Tau Pnu Medical Co., Ltd. | Mitral cerclage annuloplasty apparatus |
CN102892359A (en) * | 2010-01-29 | 2013-01-23 | 麦德风险投资有限责任公司 | Methods and apparatuses for suturing of cardiac openings |
US20110190793A1 (en) * | 2010-01-29 | 2011-08-04 | Med-Venture Investments, Llc | Methods and apparatuses for suturing of cardiac openings |
US9241790B2 (en) | 2010-05-05 | 2016-01-26 | Neovasc Tiara Inc. | Transcatheter mitral valve prosthesis |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US10449042B2 (en) | 2010-05-05 | 2019-10-22 | Neovasc Tiara Inc. | Transcatheter mitral valve prosthesis |
US9770329B2 (en) | 2010-05-05 | 2017-09-26 | Neovasc Tiara Inc. | Transcatheter mitral valve prosthesis |
US11432924B2 (en) | 2010-05-05 | 2022-09-06 | Neovasc Tiara Inc. | Transcatheter mitral valve prosthesis |
US9248014B2 (en) | 2010-05-05 | 2016-02-02 | Neovasc Tiara Inc. | Transcatheter mitral valve prosthesis |
US11419720B2 (en) | 2010-05-05 | 2022-08-23 | Neovasc Tiara Inc. | Transcatheter mitral valve prosthesis |
CN103153230A (en) * | 2010-09-29 | 2013-06-12 | 金埈弘 | Tissue protective device for coronary sinus and tricuspid valve, knot delivery device, and device for mitral valve cerclage, containing same |
WO2012043898A1 (en) * | 2010-09-29 | 2012-04-05 | Kim June-Hong | Tissue protective device for coronary sinus and tricuspid valve, knot delivery device, and device for mitral valve cerclage, containing same |
US10610216B2 (en) | 2011-04-15 | 2020-04-07 | Heartstitch, Inc. | Suturing devices and methods for suturing an anatomic valve |
US9649106B2 (en) | 2011-04-15 | 2017-05-16 | Heartstitch, Inc. | Suturing devices and methods for suturing an anatomic valve |
US10624629B2 (en) | 2011-04-15 | 2020-04-21 | Heartstitch, Inc. | Suturing devices and methods for suturing an anatomic valve |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9713529B2 (en) | 2011-04-28 | 2017-07-25 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US10537422B2 (en) | 2011-11-23 | 2020-01-21 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US11413139B2 (en) | 2011-11-23 | 2022-08-16 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US10363133B2 (en) | 2012-02-14 | 2019-07-30 | Neovac Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US11497602B2 (en) | 2012-02-14 | 2022-11-15 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US10420545B2 (en) | 2012-05-11 | 2019-09-24 | Heartstitch, Inc. | Suturing devices and methods for suturing an anatomic structure |
US11051802B2 (en) | 2012-05-11 | 2021-07-06 | Heartstitch, Inc. | Suturing devices and methods for suturing an anatomic structure |
US9706988B2 (en) | 2012-05-11 | 2017-07-18 | Heartstitch, Inc. | Suturing devices and methods for suturing an anatomic structure |
US11389294B2 (en) | 2012-05-30 | 2022-07-19 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US10016275B2 (en) | 2012-05-30 | 2018-07-10 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US10314705B2 (en) | 2012-05-30 | 2019-06-11 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US11617650B2 (en) | 2012-05-30 | 2023-04-04 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US10940001B2 (en) | 2012-05-30 | 2021-03-09 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US9345573B2 (en) * | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US20140155990A1 (en) * | 2012-05-30 | 2014-06-05 | Neovasc Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
US10383728B2 (en) | 2013-04-04 | 2019-08-20 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
US11389291B2 (en) | 2013-04-04 | 2022-07-19 | Neovase Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
KR101467373B1 (en) * | 2013-05-23 | 2014-12-10 | 부산대학교 산학협력단 | Stopper for myocardial protection and cerclage annuloplasty procedure apparatus with the same |
US10828022B2 (en) | 2013-07-02 | 2020-11-10 | Med-Venture Investments, Llc | Suturing devices and methods for suturing an anatomic structure |
US11779324B2 (en) | 2013-12-06 | 2023-10-10 | Med-Venture Investments, Llc | Suturing methods and apparatuses |
US10512458B2 (en) | 2013-12-06 | 2019-12-24 | Med-Venture Investments, Llc | Suturing methods and apparatuses |
WO2015178612A1 (en) * | 2014-05-20 | 2015-11-26 | (주)타우피엔유메디칼 | Tissue protection device for mitral valve membrane cerclage procedure |
US10729427B2 (en) | 2014-05-20 | 2020-08-04 | Taupnu Medical Co., Ltd. | Tissue protection device for mitral valve membrane cerclage procedure |
US11395658B2 (en) | 2014-07-11 | 2022-07-26 | Cardio Medical Solutions, Inc. | Device and method for assisting end-to-side anastomosis |
US10687801B2 (en) | 2016-04-11 | 2020-06-23 | Nobles Medical Technologies Ii, Inc. | Suture spools for tissue suturing device |
US11957331B2 (en) | 2017-06-19 | 2024-04-16 | Heartstitch, Inc. | Suturing systems and methods for suturing body tissue |
US11839370B2 (en) | 2017-06-19 | 2023-12-12 | Heartstitch, Inc. | Suturing devices and methods for suturing an opening in the apex of the heart |
US11202624B2 (en) | 2017-08-18 | 2021-12-21 | Nobles Medical Technologies Ii, Inc. | Apparatus for applying a knot to a suture |
US11026791B2 (en) | 2018-03-20 | 2021-06-08 | Medtronic Vascular, Inc. | Flexible canopy valve repair systems and methods of use |
US11701228B2 (en) | 2018-03-20 | 2023-07-18 | Medtronic Vascular, Inc. | Flexible canopy valve repair systems and methods of use |
US11285003B2 (en) | 2018-03-20 | 2022-03-29 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
US11931261B2 (en) | 2018-03-20 | 2024-03-19 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
US11779742B2 (en) | 2019-05-20 | 2023-10-10 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
Also Published As
Publication number | Publication date |
---|---|
US8777991B2 (en) | 2014-07-15 |
EP2401970B1 (en) | 2013-05-08 |
US20120289977A1 (en) | 2012-11-15 |
EP1605833A2 (en) | 2005-12-21 |
WO2004082523A3 (en) | 2005-03-31 |
EP2401970A1 (en) | 2012-01-04 |
US20040181238A1 (en) | 2004-09-16 |
CA2754649A1 (en) | 2004-09-30 |
AU2004222384A1 (en) | 2004-09-30 |
US7381210B2 (en) | 2008-06-03 |
WO2004082523A2 (en) | 2004-09-30 |
CA2518962A1 (en) | 2004-09-30 |
WO2004082523A8 (en) | 2005-07-21 |
CA2518962C (en) | 2012-01-03 |
JP4558718B2 (en) | 2010-10-06 |
JP2006520240A (en) | 2006-09-07 |
CA2754649C (en) | 2015-04-28 |
US8226666B2 (en) | 2012-07-24 |
US20090318871A1 (en) | 2009-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8777991B2 (en) | Mitral valve repair system and method for use | |
US9999419B2 (en) | Single catheter heart repair device and method for use | |
US11672662B2 (en) | Short-throw tissue anchor deployment | |
US7094244B2 (en) | Sequential heart valve leaflet repair device and method of use | |
US20230310153A1 (en) | Tissue anchor deployment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: EDWARDS LIFESCIENCES CORPORATION, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ZARBATANY, DAVID;TIEU, TAI;PUNG, PONAKA;AND OTHERS;SIGNING DATES FROM 20030905 TO 20030922;REEL/FRAME:024824/0939 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |