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Número de publicaciónUS20090076847 A1
Tipo de publicaciónSolicitud
Número de solicitudUS 12/271,224
Fecha de publicación19 Mar 2009
Fecha de presentación14 Nov 2008
Fecha de prioridad29 Ago 2001
También publicado comoUS7461006, US20030046110, US20170061080, WO2003021389A2, WO2003021389A3
Número de publicación12271224, 271224, US 2009/0076847 A1, US 2009/076847 A1, US 20090076847 A1, US 20090076847A1, US 2009076847 A1, US 2009076847A1, US-A1-20090076847, US-A1-2009076847, US2009/0076847A1, US2009/076847A1, US20090076847 A1, US20090076847A1, US2009076847 A1, US2009076847A1
InventoresVictor Gogolak
Cesionario originalVictor Gogolak
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Method and system for the analysis and association of patient-specific and population-based genomic data with drug safety adverse event data
US 20090076847 A1
Resumen
A method for assessing and analyzing one or more drugs, adverse effects and associated risks, and patient characteristics resulting from the use of at least drug of interest is disclosed. The method comprises the steps of selecting one or more cases for analysis, said cases describing the behavior between at least one drug of interest and a patient genotype; profiling statistically derived values from multiple cases related to the safety of the at least one drug, wherein at least one filter is employed for deriving said values; at least one data mining engine; and an output device for displaying the analytic results from the data mining engine. A system for performing the method is likewise disclosed.
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Reclamaciones(16)
1. A method for assessing and analyzing one or more drugs, adverse effects and associated risks, and patient demographics resulting from the use of at least drug of interest, comprising the steps of:
(a) collecting data from a plurality of sources comprising drug information, adverse effects relating to drugs and patient demographics;
(b) generating a relational database for relating drug information, adverse effects and patient demographics.
(c) selecting at least one case for analysis, the at least one case describing the behavior between at least one drug of interest and a patient genotype;
(d) profiling statistically derived values from multiple cases related to the safety of the at least one drug, wherein at least one filter is employed for deriving the values;
(e) submitting the values to at least one data mining engine; and
(f) displaying the analytic results from the data mining engine through an output device.
2. The method of claim 1, wherein analyzing using a data mining engine comprises correlating or proportionally comparing any two data types, wherein the data types are drug, adverse effects, or patient demographics.
3. The method of claim 1, wherein the data is cleaned, wherein cleaning comprises removal of noise, spell checking, and removal of redundant entries.
4. The method of claim 1, wherein the relational database comprises stored data which is mapped to tokens, wherein a token comprises a standardized search term.
5. The method of claim 4 wherein a token is selected from the group of reference sources consisting of MEDRA, WHO Drug Directories, FDA Orange Book, COSTART, NDCD, GPRD and WHOART.
6. The method of claim 1, wherein steps (a)-(f) are performed in a network environment.
7. The method of claim 1, wherein the demographics are age, sex, weight, diet, reactions, environment, illness, dosage, genotype, outcome, report source or concomitant drugs.
8. The method of claim 1, wherein the data mining engine is a correlator, a proportional analysis engine, or a comparator.
9. A system for assessing and analyzing one or more drugs, adverse effects and associated risks, and patient demographics resulting from the use of at least one drug of interest, comprising:
(a) a selector for selecting one or more cases for analysis, the cases describing the behavior between the at least one drug of interest and a patient genotype;
(b) a profiler profiling statistically derived values from multiple cases related to the safety of the at least one drug, wherein at least one filter is employed for deriving said values;
(c) at least one data mining engine for submitting the values to; and
(d) an output device for displaying the analytic results from the data mining engine.
10. The method of claim 9, wherein analyzing using a data mining engine comprises correlating or proportionally comparing any two data types, wherein the data types are drug, adverse effects, or patient demographics.
11. The method of claim 9, wherein the data is cleaned, wherein cleaning comprises removal of noise, spell checking, and removal of redundant entries.
12. The method of claim 9, wherein the relational database comprises stored data which is mapped to tokens, wherein a token comprises a standardized search term.
13. The method of claim 9 wherein a token is selected from the group of reference sources consisting of MEDRA, WHO Drug Directories, FDA Orange Book, COSTART, NDCD, GPRD and WHOART.
14. The method of claim 9, wherein steps (a)-(d) are performed in a network environment.
15. The method of claim 9, wherein the demographics are age, sex, weight, diet, reactions, environment, illness, dosage, genotype, outcome, report source or concomitant drugs.
16. The method of claim 9, wherein the data mining engine is a correlator, a proportional analysis engine, or a comparator.
Descripción
    RELATED APPLICATIONS
  • [0001]
    This application is a continuation application of U.S. Ser. No. 10/229,119, filed Aug. 28, 2002, which claims the benefit of U.S. Provisional Application No. 60/315,525, filed Aug. 29, 2001, and is related to each of the following applications: U.S. patent application Ser. No. 09/681,586, filed May 2, 2001; U.S. patent application Ser. No. 09/681,587, filed May 2, 2001; U.S. patent application Ser. No. 09/681,583, filed May 2, 2001; and U.S. patent application Ser. No. 09/845,722, filed May 2, 2001, the disclosures of which are incorporated herein by reference in their entireties.
  • TECHNICAL FIELD
  • [0002]
    The present invention relates to a drug safety database. More particularly, the invention relates to a method and system for creating and utilizing a database that relates drugs, adverse events, patient characteristics, and in particular, genetic information.
  • BACKGROUND OF THE INVENTION
  • [0003]
    Publicly and privately developed pharmacological data is readily available from both reference data and source data. Statistical information has been collected for many years on adverse reactions to drugs, including information on prescriptions, nutraceuticals, and over-the-counter medications. With this information, databases have been created that provide both reporting and data analysis of adverse drug reactions. Typically, this data is provided in a format that is not amenable to searching, such as in ASCII format.
  • [0004]
    Additionally, these databases are often in different structures and language formats, decreasing the efficiency and impeding effective use. Further, the variations in terminology and software languages employed by these disparate databases complicates conventional queries, making the results unreliable.
  • [0005]
    Various methods and techniques have been developed to address the need to provide ready access to pharmacological data and adverse events. However, none of these partial solutions, such as the Freedom of Information data provided by the FDA (which relies on “flat files”) or standard dictionaries such as the Medical Dictionary for Regulatory Activities (MedDRA™), have been integrated to allow consistent analysis and results.
  • [0006]
    Pharmacogenetics is the study of individual response to drugs as a function of genetic differences. These responses relate to how a drug functions in any given individual, how it is metabolized, its toxicity and dosage requirements. With the human genome project, pharmacogenetics has expanded into pharmacogenomics. Pharmacogenomics goes beyond pharmacogenetics, with the potential to find uses from drug discovery and development, target discovery and validation, and clinical trials; and to get that information into the doctor's office so that the right medicine is given to the right patient at the right time.
  • [0007]
    For pharmacogenomics to be effective, markers are needed that are indicative of the connection between drug response and genetic makeup. One such marker that is being diligently pursued is the single-nucleotide polymorphism (SNP). Databases are presently available that furnish a map of over a million SNPs. From this data, information has been collected regarding the allelic frequency of a SNP within an ethnically diverse population. There are also other databases which are more narrowly tailored and focus only on particular groups of SNPs such as those that code for proteins; provide a data set related to ADME (absorption, distribution, metabolism and excretion) genes and SNPs that are associated with how the body responds to drugs. Instead of single SNPs, some databases focus on SNPs that are found in haplotypes, which work together to cause a particular drug response.
  • [0008]
    Pharmacogenomics is being applied to pharmacodynamics, how a drug affects a disease. Additionally, pharmacogenomics is being applied to pharmacokinetics, or how the body processes a drug. While the pathway for drug intervention is usually well known, there are two important mechanisms to consider in pharmacokinetics—the pathway that metabolizes the drug itself, and other pathways that drugs and their metabolites may inadvertently and adversely affect. It is in these two areas that drug safety comes into play. In the first, there are distinctions among human genotypes in the ability to metabolize drugs. If a drug is not metabolized as predicted in the clinical trials, it could potentially build up to toxic levels. Different segments of the population metabolize drugs differently, providing a variety of potential reactions to a drug which can impact the dosage, safety, and efficacy of that drug and its usefulness for an individual patient.
  • [0009]
    A drug and its metabolites may affect other pathways for varying genotypes (or phenotypes). Currently available data on drug safety, as collected by regulators around the world, does not address genetic variances, although hundreds of different reactions are reported to occur in many body systems.
  • [0010]
    Accordingly, what is needed is an understanding of the impact of differing rates of metabolism on adverse drug events. Additionally, there is a need for a database providing drug safety data as collected by regulators around the world, particularly from a genetic perspective. Further, there is a need for a relational database that can assimilate and correlate these two sets of data, particularly from a genomic perspective.
  • SUMMARY OF THE INVENTION
  • [0011]
    Using data, meta-analysis, standardization of terminology and sophisticated association algorithms, the present invention addresses the needs in the above area of drug safety by providing a system of relating drug safety data, adverse reactions, pharmacogenetics, pharmacogenomics and demographic data.
  • [0012]
    The system described herein is in the area of genomic drug safety, and accordingly provides a method to evaluate existing and/or potential drugs from a genomic point of view. This method takes the drug dimension, with its different characteristics (e.g. chemical class) and adds information regarding the metabolic pathway of drugs (including current and historical drugs), thereby creating genetically relevant taxonomies of drugs. The method also includes demographic information such as the phenotype and genotype of a particular patient involved with a particular reaction (case). These extensions allow the resulting application to correlate drugs with the metabolizing characteristics of specific patient genotypes. As such, the method shows how these drug/genotype interactions lead to increased or decreased chances for particular adverse reactions.
  • [0013]
    The method creates and utilizes a database which correlates drugs, adverse events and patient characteristics. The method focuses primarily on genetic information, particularly SNPs and gene variants that relate to drugs or drug classes and adverse reactions. Whereas drugs generally metabolize in one or two pathways, adverse events can occur in any of the body systems or pathways, even those not originally believed to be impacted by the drug, leading to extreme complexity.
  • [0014]
    In accordance with the method, data is collected, for example, from a multitude of sources, and is then analyzed and stored in a standardized data structure. A method of developing “mappings” allows data to be consistently compared and analyzed even if the original sources use incompatible language.
  • [0015]
    The method takes existing drug data on efficacy and safety, such as is found in drug labels, monographs, and post market information, and solicits new data, such as through clinical trial data in the literature, or from patient and medical histories, and then associates those relationships with patient characteristics including genetic and environmental factors (e.g., diet, age, sex, race, etc.).
  • [0016]
    The resulting databases can be used in drug research, using the analytic techniques as provided herein can be used to sort among lead compounds to determine those with the lowest possible side effects based on population genetics. It can also be used in prescribing drugs, matching a patient not only to the most efficacious drug, but also to the most effective drug with the least side effects and the lowest required dosage based on the patient's specific genetic and environmental markers.
  • [0017]
    Since it is possible to check all combinations of genotypes against all drug information, an additional benefit of the present invention is the capability to prepare a database of known relationships and apply them prior to or at the point-of-care (POC). This allows the physician to check a particular patient profile against the drug to be prescribed to assess the risk of an adverse drug reaction for that patient.
  • [0018]
    The method described herein provides risk analysis of the use of particular drugs based on chemical, proteomic, genomic, and demographic information for both diagnostic and therapeutic purposes. The method uses an innovative complex of tools that associate historical drug safety data with both drug characteristics and patient genetic make-up. One embodiment of the method includes summary data on populations that have had adverse drug reactions along with their genetic profile. Another embodiment provides broad population genetics data for prescribing decisions made on drugs and therapeutics, based on the likelihood of adverse drug reactions. A further embodiment compares individuals with the drug reaction profile of a given population. For example, if a patient profile matches the genetic profile of those prone to liver disorders, then the physicians/pharmacists will avoid prescribing or dispensing drugs with potential adverse liver effects to that patient.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0019]
    Certain embodiments of the disclosed invention will now be described in greater detail, and exemplarily shown in the associated drawings in which like reference numerals have been used to indicate like and similar components, arrangements of components, and functional features of the same. The illustrative drawings disclose exemplary and, in some cases, alternative embodiments of the invention, in which regard:
  • [0020]
    FIG. 1 is a schematic block diagram illustrating one embodiment of a method of mapping various data sources.
  • [0021]
    FIG. 2 is a block diagram illustrating one embodiment of the steps utilized in performing the method of the present invention.
  • [0022]
    FIG. 3 is a block diagram illustrating one embodiment of the present invention integrating information on drugs, demographics and adverse reactions.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0023]
    The present invention comprises a system and method for creating, storing and using patient-specific and population-based genomic drug safety data including at least one or more integrated databases; a selector for selecting at least one drug for analysis (based on the generic, brand name or therapeutic category); a profiler for displaying statistics that describe one or more behaviors of the drug in multiple dimensions; a series of at least two filters and the means to control the filters individually and in combination; at least one data mining engine. Preferably, the data mining engine is a correlator, a proportional analysis engine, and a comparator; and a graphical user interface for displaying the results of the analysis.
  • [0024]
    Dimensions such as age, sex, weight, diet, dates, reactions, doses, outcomes, illnesses, report source, and concomitant drugs can be analyzed in combinations of two dimensions, in combinations of three dimensions, in combinations of four dimensions, and other combinations. The method described herein also permits analysis of the association between outcomes and other dimensions.
  • [0025]
    FIG. 1 shows the relationship among the various data sources and how data is drawn into a consistent data structure, one that is referenced to standard dictionaries, regardless of which dictionaries were used in the source. In the embodiment of the system and method illustrated in FIG. 1, source data is gathered to create a composite genomic relational drug safety database 10. This source data is collected from databases covering three general areas: adverse event database 20, drug information database 30, and patient or genomic database 40. Adverse event source database 20 includes data on drugs, reactions, demographics and outcomes. Sources of this data are databases such as, but not limited to, the FDA's Spontaneous Regulatory System (“SRS”), the FDA's Adverse Event Reporting System (“AERS”), the World Health Organization Adverse event database, or other country-specific regulatory or epidemiological databases, such as the UK Advert system and the General Practice Research Database (GPRD) as well as other databases and sources, which may be domestic, foreign and/or international in scope. Unexpected or previously unrecognized adverse drug effects can take the form of single reactions, groups of reactions, or increases in a labeled reaction. These adverse reactions may be due to the exposure of a greater number of people to the drug, or the reactions of a particular demographic group. Such information is continually updated as new cases are released and can be added to the information for use in the present method.
  • [0026]
    Adverse event data 20 may also be provided, for example, from pharmaceutical corporations, hospitals, physicians, health insurers, and state, federal and international agencies. A primary source of pharmaceutical industry data is the individual adverse event databases of the various pharmaceutical corporation safety departments. In each case, source data may be focused on clinical trails, post-market surveillance, research databases, or the like. Unedited data in each source database is referred to as “verbatim.” Clinical trial data available in literature includes safety data. Other information is collected and can be accessed from the World Health Organization (WHO), PEM, the General Practice Research Database (GPRD), and so forth.
  • [0027]
    Drug information source database 30 may include the type or class of drug, metabolic pathways, and drug pharmacokinetics and pharmacodynamics. Such drug source database 30 provides drug taxonomies that offer characteristics of drugs including metabolites, clearance rates, peak serum levels, pharmacodynamics, therapeutic category, chemical structure, or a way to group drugs and explore the relationship to both reactions and genotypes.
  • [0028]
    Patient source database 40, both records with the name and patent identification removed and summarized records, may include genetic data, demographic, phenotypic, and drug and patient adverse drug reaction (“ADR”) history. This source data may be acquired by accessing, soliciting, or assembling data on patients experiencing adverse drug reactions, and comparing the data against data from a control set of a broad population who are not taking the drug/drugs in question in order to see the relationship between certain reactions and genotype/phenotype. For example, light skinned people (a kind of phenotype with genotypic background) are generally prone to sunburn and may additionally be particularly sensitive to certain drugs. Population genetics information includes a wide variety of sources including DNA samples solicited directly from people who have had documented adverse reactions to certain drugs.
  • [0029]
    In addition to source data, reference data 50 from various accepted canonical references, including dictionaries, thesauruses, taxonomies, and hierarchies, is gathered and used in the genomic drug safety database 10. Examples of such references include the Medical Dictionary for Regulatory activities (“MedDRA™”), National Drug Code Directory (“NDDC”), and the FDA Orange Book. The method described herein has the capacity to substitute and manage both source and reference data.
  • [0030]
    The basic steps of the method are shown in FIG. 2. In step 100, data is assembled from sources that relate drugs to reactions and characteristics, and patients to medical history and genotype as described above with respect to FIG. 1. In step 200 of the method, data is implanted into a data structure, information that has been broken down to its most fundamental level is mapped to reference dictionaries, and source data is parsed into a relational database structure. For data sources not already in a relational database structure, transformation from raw source data to a relational structure preferably includes parsing each data source into an image with fields tailored to its corresponding source. Subsequently, the images are consolidated into a single safety table space. Since the database can be simple or complex, the method provides the ability to add many “dimensions” such as age, sex, dates, reactions, doses, outcomes, report source, and concomitant drugs. These dimensions can be entered as structured, narrative, numerical, or categorical variables. Hierarchies in all dimensions (in both preferred and custom paths) are defined as required by the particular end user.
  • [0031]
    Since several of the most favored data sources are not published in a format that lends itself to direct query, e.g., SRS is available from the U.S. Government only as delimited ASCII data, parsing such data into a relational database model allows the use of leveraging data management tools, which are ineffective on flat files. In preferred embodiments of the present method, the safety table space provides a common set of fields for the parsed source data.
  • [0032]
    In one method, an information management system integrates data from a plurality of interconnected local databases, providing users with access to a virtual database that ties drug, reaction and patient parameters together. In another method, a record repository is provided for accepting data from a medical service provider and linking it to a patient database, allowing documents for a patient to be retrieved through demographic data. An additional method provides an information extraction system wherein users ask questions about documents in a database and the system responds with information extracted from the documents. In yet another method, copious amounts of data regarding adverse events associated with a particular product are received and analyzed in view of known adverse events associated with the product, providing new uses for the product as well as a catalog of adverse event information for a large number of population sub-groups.
  • [0033]
    FIG. 3 shows the relationship of three information categories and their various parameters (characteristics). The category entitled “Reactions” of “Adverse Reactions” (20) has been structured by various means: COSTART, WHOART, and most recently MedDRA™. “Reactions” are additionally characterized by their seriousness (e.g. the FDA's “Designated Medical Events,” or DME). The method provides a means to integrate these various dictionaries. The second entity is the product or “drug”. It is classified by therapeutic class, chemical class, metabolic pathway, metabolites or structure. The method provides a system to integrate these parameters. The last entity, named “demographics,” has typically rested on either broad parameters such as age and sex, or on the more specific characteristics of weight, diet, climate, phenotype, proteome, genotype and environment. Recent work in genetics has identified a critical SNP or gene, a defining characteristic for an individual—the genotype.
  • [0034]
    In one embodiment, data cleanup may be performed independently of parsing source data into a safety database. This allows cleanup to be continual, ongoing, and iterative, either before or after one or more source databases are processed into the pharmacovigilance database which determines if the events are or are not due to the drug. Source database cleanup is an incremental process, proceeding from automated cleanup of certain errors, through human-assisted cleanup of ambiguous entries, to human correction of identified gross errors. Specific cleanup tasks include noise reduction (e.g., suppression of non-alpha characters noise words and combination words), adjustment for misspellings, adjustment for dislocations, transpositions and resolution of possible redundant entries.
  • [0035]
    In a preferred embodiment, reactions, drugs, and counts of the occurrence (by case and absolute) of each are extracted from the parsed source data. The counts are then grouped. In this embodiment, grouping is by order of magnitude of the count.
  • [0036]
    In a preferred embodiment, the bulk of data cleanup is performed on a computing platform separate from database storage. A spreadsheet application, such as Microsoft® Excel® is used to track cleanup operations. For example, the first column in such a spreadsheet may contain the verbatim term; the second column may contain a noise-suppressed verbatim term; the fourth column may contain the spell-checked verbatim term, and so on. Other data cleanup applications, such as Metaphone (discussed below), also reside on this separate computing platform. However, cleanup applications need not reside on a separate computing platform, or may be accessible via the Internet or other computer network.
  • [0037]
    As a part of the data cleanup operation, noise reduction may be performed on the data. Noise reduction involves suppression of words and characters that are typically unnecessary in determining the correct name for drug or reaction verbatim. Noise words and characters include, but are not limited to non-alpha characters (such as numbers, diacriticals, brackets, and control characters), words (e.g., “mg” or “tablet”), combination words (e.g., “20 mg” with no space). For example, both “Tylenol (500 mg)” and “Tylenol Capsules” would be reduced to “Tylenol.” A list of noise words and noise punctuation is stored in database tables associated with lexical processing. Non-alpha characters, such as control characters, are also suppressed at this stage.
  • [0038]
    After noise reduction, misspellings are detected and corrected using known tools such as spell checkers, sound-alike suggestion programs, a verbatim replacement table, and human inspection. A preferred spell checker operates on noise-suppressed verbatim terms, making a series of spelling variations on terms not found in the reference sources. These variations are used as the basis for searching reference sources and suggesting candidate canonical terms. Reference sources include standard and special-purpose dictionaries. The variations introduced include:
      • adding an extra character to the term, e.g., allowing noise-suppressed verbatim such as “proza” to be searched as “prozac”;
      • removing a character from the term, e.g., allowing noise-suppressed verbatim such as “prozzac” to be searched as “prozac”;
      • swapping adjacent characters, e.g., allowing noise-suppressed verbatim such as “rpozac” to be searched as “prozac.”
  • [0042]
    In addition to a spelling suggester, a sound-alike program, such as Metaphone or Soundex is employed to suggest variations. Metaphone is a published phonetic code algorithm similar to Soundex, which is a sound based indexing system. Every word has a four-letter Metaphone value that can be calculated. The Metaphone suggester calculates the Metaphone value for each entry in the reference sources and for each unresolved verbatim term. Those reference source terms having a Metaphone value matching that of an unresolved verbatim term will be offered as a suggestion to a database developer for resolution. For example, the Metaphone value for both “prosac” and “prozack” is PRSK; the Metaphone value for both “Claritin” and “Klariton” is “KLRT.” Where no candidates satisfy the developer, an option is provided for accepting a surrogate term from the developer.
  • [0043]
    Various embodiments of the method described herein include steps for capturing and using domain specific lexical knowledge not easily applied through noise reduction or spell checking. At the basic level, this amounts to use of a replacement table, containing mappings from known errors to corrected canonical terms. On a more sophisticated level, as domain-specific knowledge is accumulated, autocoders are employed to capture human decision-making experience regarding cleanup.
  • [0044]
    Human interaction is particularly useful in identification and correction of dislocation errors, i.e., where a term valid in one field (e.g., headache/reaction) appears in a field where it is not valid (e.g., headache/drug). Dislocation errors are identified in preferred embodiments where a term does not fit the type of the field it is found in, but nonetheless exists in reference sources outside the scope of the particular field.
  • [0045]
    Redundant entries are identified and removed with operator assistance. A “case” may include all data regarding the adverse events experienced by one person taking a drug. A sequence of events regarding a single individual taking a drug should not be recorded as separate cases (potentially duplicating the adverse events associated with the case). This is important for correct statistical views of the data. The method provides tools to operators to allow identification and consolidation of redundant cases. In preferred embodiments of the present invention, multiple cases involving the same person over a contiguous period are presented to an operator for determination as to whether or not such entries actually represent one case with multiple (or possibly single-occurrence, multiple-reported) events.
  • [0046]
    For example, if a case concerning an “eye pain” reaction is amended fifteen times, only one instance of eye pain should be aggregated for this individual case. Through record linking, preferred embodiments of the method match successor reports with their predecessors using data inherent in the records, and compare other information in the records to gauge the quality of the match. For example, two cases may match on the “case identification” field, or a “drug manufacturer identification” field, or a “report date.” Those cases known to be redundant, and those cases showing a link between records, are presented to researchers for resolution. In alternate embodiments, resolution between likely redundant cases is accomplished via an expert system.
  • [0047]
    It should be understood that underlying verbatim terms are not changed by application of noise suppression, the use of spell checkers, the resolution of dislocations, or the resolution of redundant entries. Verbatim terrns, such as drug and reaction terms, that have been parsed into a safety database and cleaned are then mapped to “tokens” from the reference data sources. The word “token” refers to the specific term(s), from one or more of the reference sources, that is associated with one or more of the verbatim terms in a manner that allows a search for the token to return results containing the verbatim term(s) linked to the token. Where an exact match exists between a verbatim term (source or cleaned) and a reference term, the verbatim term is mapped to the reference term as token. Where no exact match is found between verbatim (cleaned or otherwise) and reference data terms, the present invention presents a series of steps for resolving such unmatched terms.
  • [0048]
    In addition to corruption in verbatim data, valid variations in terminology may also be resolved through mapping to reference data tokens. For example, “PROZAC” and other trade names for flouxetine are preferably mapped to the generic “flouxetine.” In another example, luliberin, gonadotropin releasing hormone, GnRH, gonadotropin releasing factor, luteinizing hormone releasing hormone, LHRH, and LH-FSH RH are equivalents and may be considered as such for analyzing adverse effects. Furthermore, different chemical derivatives, such as esters, salts, or acidic or basic forms of the same drug may be grouped together, where a reference data term exists, under the same token in order to analyze adverse drug events.
  • [0049]
    In accordance with the method, source data verbatim terms may be nominated as token candidates; frequency of occurrence and absolute count being typical bases for nominating a term as a token candidate. Verbatim drug, patient and reaction terms may be grouped by order of magnitude of absolute count. For reactions, token candidates are chosen from accepted reference sources such as MedDRA™, Coding Symbols for a Thesarus of Adverse Reaction Terms (“COSTART”), GPRD, and World Health Organization Adverse Drug Reaction Terminology (“WHOART”). For drugs, token candidates are chosen from corresponding canonical sources such as the National Drug Code Directory (“NDCD”), WHO Drug Dictionaries for drugs, and the FDA's Orange Book.
  • [0050]
    Individual verbatim terms are then mapped to the selected tokens. According to the present method, this process may be used for multiple database dimensions in addition to drug and reaction, e.g., outcomes, where the definition of “serious” outcomes can differ over time and between reference sources. This mapping enables those searches of the database focused on tokenized fields, e.g., drug, patient, and reaction fields, to be executed with greater confidence. Using the mapping approach, variability in source event data entry, typically a difficult-to-control aspect of data collection on a large scale, is mitigated as a source of error.
  • [0051]
    Corrected verbatim is mapped to reference canonical terms and structures. As noted earlier, where an exact match exists between a verbatim term (source or cleaned) and a reference term, the verbatim term is mapped to the reference term as token. Where no exact match is found between verbatim (cleaned or otherwise) and reference data terms, the method presents a series of steps for resolving such unmatched terms. In those instances where a user is presented with a number of assigned unresolved entries, the method presents the user with suggestions identified by lexical processing (e.g., Metaphone, fixed list) for each unresolved verbatim term. The user may then select from this list or enter a surrogate term. After selecting a candidate term or entering a surrogate term, a list of generic drug names will be shown (if the matched term was indeed a trade name rather than a generic). At this point, a user can either save the mapping or modify the list of generic terms. This last option will allow a user to override the list of generics or to enter new chemical compounds as they are developed.
  • [0052]
    Cleaned source data reaction terms may be mapped to standardized hierarchies such as WHOART, COSTART, and MedDRA. Specifically, cleaned source data reaction terms are mapped to multiple levels (and possibly multiple entries within a level) of the hierarchy. In preferred embodiments, mapping of cleaned verbatim reaction terms proceeds in a fashion similar to mapping of drug terms. While the preferred embodiments perform mapping on cleaned source data, it should be understood that mapping may be performed on uncleaned, or even unparsed, source data.
  • [0053]
    Transparency in the process of moving from source data verbatim terms to a cleaned safety database with verbatim terms mapped to tokens is important to both database developers/operators and to end users. The present method captures the way source data terms have been cleaned and mapped as the “pedigree” of each term. The pedigree of a term is the link between the mapped term and the decisions made during data cleanup. End users typically wish to verify the pedigree of the data they use. In those embodiments, retained data includes one or more of the following as appropriate: verbatim term, token mapped to, source of the verbatim term, number of occurrences of the verbatim term, number of cases in which the verbatim term appears, which type of cleanup (if any) was performed, a cross-reference to where the token is defined, and dates of the earliest and latest reported occurrence.
  • [0054]
    The method may be implemented on a single computer or across a network of computers, e.g., a local area network or on or across the Internet. Preferred embodiments include implementations on computer-readable media storing a computer program product performing one or more of the steps described herein. Such a computer program product contains modules implementing the steps as inter-related functions as described herein. In a networked implementation, the databases, data management software and analytical software may reside in any combination of one or more local workstations and one or more network servers.
  • [0055]
    As described above, the database used in the present method sets up different information sources in a composite relational data structure, as illustrated in FIG. 3. This composition correlates patient information 40 (demographics, genetic make-up, environment), drug information 30 (class, therapeutic use, structure), and events of adverse reactions 20 (at different levels of detail). Along with DNA sample references and detailed individual medical histories, these are assembled and referenced into cases. The information in these cases includes both the verbatim data from the original sources as well as a standard reference dictionary term for each element of data. The latter is critical to ensure the ability to compare cases across drugs, patients and events.
  • [0056]
    Referring again to FIG. 2, in step 300 of the method, described herein, statistical associations are analyzed. The present method looks at cases and determines two outcomes:
      • a. Whether there is an indication of association among a drug, a reaction or group of reactions, and a genotype
      • b. The distribution of that association in a population.
        The first outcome is determined from one of four techniques—
      • 1. Proportional analysis against a variety of backgrounds,
      • 2. A correlation of two or more parameters (e.g., Pearson product-moment correlation coefficient),
      • 3. Differential analysis (i.e., changes over time or another dimension), and
      • 4. Neural networks (one of several paradigms that associate items and provide weights based on the statistical distribution of outcomes), or other machine learning algorithms such as Hidden Markov models, Bayesian networks and kernel methods among other methods known in the art.
  • [0063]
    Note that the method provides a way to apply these techniques, in a novel way, to categorical variables. That is, variables that retain non-numeric values. Reactions such as headache, rash, genotype, drug chemical class, etc. are the key parameters. The application of the Pearson Product-Moment using a binary scale (0 or 1) that means that one of possibly hundreds of parameters is there or not there, is a unique application of the Pearson technique. This application of the Pearson P-M rests on the ability of the method to link data to consistent dictionaries and also calculates millions of pairs.
  • [0064]
    Various methods are available according to the present method for using the database to analyze relationships. The database provides a classification taxonomy structure for drug and genomic data. As taxonomies develop over time (typically based on new ways of grouping drugs or new ways of grouping SNPs and gene variants), the method provides parameters and hierarchies to enable richer correlations. As drugs or genes are grouped, they provide the basis for “coherent processing” in signal detection, i.e., they have the ability to group information to reinforce the “signal” that a particular drug or genotype is, in fact, a possible cause of a reaction. Similar structures are used for reactions and outcomes (e.g., hospitalization or death) as well as a drug classification template that allows mapping between drug and pathway, proteome, drug classification and others, in search of potential associations at the drug level; and a SNPs and gene classification template that allows a variety of high/medium/low level detail (e.g., broad SNPs region for certain reactions to specify SNPs related to Stevens-Johnson Syndrome).
  • [0065]
    The present method analyzes the multivariate relationships of drug safety, therefore making the database more usable to researchers and clinicians. Many aspects of the use of drug, reaction, and genetic/environmental information depend on having the ability to consolidate data across many different databases, with specific applications of standard categories and standard dictionaries allowing the consolidated data to provide meaning. These applications include: a database on demographics, drugs, reactions, and outcomes linked to standard dictionaries; a selector/profiler/filter that allows a researcher to hypothesize on (i.e., groups of reactions or symptoms) and filter confounding elements (e.g., the known pathway effects etc.) in order to enhance the ability to uncover unwanted effects, by analyzing similar drugs chemically, or pathways genetically; a set of analytical engines that respectively analyze different aspects of the database (which is basically organized into historical or current “cases”, i.e. a patient), with a certain drug or drugs, and with certain reactions and outcomes. These include: proportional Engines (PRR, OR) that look for anomalies against a background; correlators that look for associations; differing engines that compare different sets of data (e.g., one population or another) in search of variations; Neural Network and other learning machine paradigms that apply heuristics to large databases in order to model and classify, e.g. by comparing weights of associations; a set of data display, viewing and visualization that helps the researcher use his/her insight and pattern recognition capabilities to see, for example, genetic patterns or patterns of pathways that are involved for certain genotypes. The present method then, uses both automated and semi-automated techniques to blend and create the best data mining and hypothesis testing.
  • [0066]
    Even though the efficacy of a given drug may only involve one or two metabolic pathways, and therefore body systems, adverse reactions may stem from one or several of the many different pathways inherent in the human organism. Thus, the present method combines detection as well as association algorithms to help identify the relationships among a drug, a given patient genotype, and the reactions and outcomes that could result.
  • [0067]
    Based upon the above, the present method accesses the system database, wherein a set of cases may be selected for analysis. Having selected the case-set of interest, the method then preferably proceeds to a profile, which preferably displays statistically-derived values that describe the behavior of the drug of interest based upon patient genotype. From the profile, the method can then preferably proceed to employ one or more filters that permit recalculation of the statistics by selecting among available variables. Once a set of cases is determined, for example, by the use of one or more filters, the cases can then preferably be submitted to one or more data mining engines. Such data mining engines may include a correlator engine, which provides information on analyses that have been previously completed—including date and time, task number, and generic drug. Each listing ends with a hyperlink that a user can employ to view the results of a search. A “delete” function is preferably provided to manage this list.
  • [0068]
    Step 400 of the method provides the data mining and extraction capabilities in which the results of statistical analysis in step 300 are compared against selected thresholds or criteria to extract the data of interest. Based on the above techniques, each dimension in the present invention will have a natural “filter” framework based on the number of parameter (dimension) variables and their number in the database. Within this framework, one or more of a combination of filters can be used to select “cases” and perform a restricted analysis of step 300. This interaction between steps 300 and 400 allows an individual researcher to use his/her hypothesis to adjust the analysis. For example, a set of adverse events are really a reflection of non-efficacy of a certain drug, such as reported adverse event of “depression” for a patient taking an anti-depressant. These reactions could be filtered out as part of step 300.
  • [0069]
    Output from the data mining engines is preferably displayed using a graphical viewer, which permits the user to present the data in a variety of formats, including, but not limited to a sortable table, a sortable line listing, and a radar screen, thus, allowing rapid identification of signals and providing the user the ability to drill down to individual case details.
  • [0070]
    Alternatively, in another preferred embodiment, the method of the present invention permits choosing a profile, applying one or more filters, processing the set of cases using the data mining engines, and displaying the results for a user or viewer.
  • [0071]
    The present invention therefore includes a means to assemble data, create a database, and finally produce a summary and individual outputs based on the implied parameter “triplet” consisting of patient, drug, and adverse event data. The result is a structural database that combines a variety of drug characteristics, drug class and pathway characteristics, and population as well as individual genetics. The present invention provides a method for applying genomic-based adverse event data in a drug lifecycle. There are many research and medical situations where it is critical to associate individual patient's genotype or the general population's genetic distribution to Adverse Drug Reactions (“ADRs”). The ADR arena is complex because it involves many possible human metabolic pathways. Due to this complexity, and the extremely difficult tracing of hundreds or thousands of possible causes for thousands of reactions, the database of the present invention was developed based on clinical outcomes. In this respect, the system and method works backward from ADRs toward the statistical distribution of genotypes potentially associated with the event. The grouping of SNPs and gene variants provides a “cluster” that can be associated with a higher-than-expected reaction. For example, it may be that roughly 1% of patients experience headache with a particular drug, but 30% of those patients sharing a particular genotype have experienced headache with the drug. This may potentially link that genotype to headaches associated with the drug.
  • [0072]
    With efficient and effective analysis of adverse drug effects, pharmaceutical research and development professionals can learn more details of the reaction profiles of drugs and the at-risk populations who may be prescribed those drugs. This information would allow a more effective selection of lead compounds and would ultimately lead to development of drugs with reduced risk of adverse effects.
  • [0073]
    The system and method disclosed herein may be used during the research and pre-clinical trial stage of drug development for reviewing a set of drugs against the genetic background of a population in order to determine the ADR profile. The system and method may also be used during clinical trials, comparing the actual experience of ADRs with the database, for example, using proportional analysis (or any of the above techniques) to see if the trial population exhibits unexpected adverse events. The system and method may additionally be used during the diagnosis and prescription process at a point of care for checking a particular patient's genetic profile against a drug to assess or determine the probability of an adverse drug reaction for a drug (especially those considered serious by the healthcare provider) compared to other drugs. The system and method may further be used on a continuing basis for collecting post-market data on drugs by retrieving the genetic profile of patients exhibiting adverse events for a drug, and updating the present invention database with this information.
  • [0074]
    It should be appreciated that in all these genetic comparisons, there is potential to identify phenotypic markers (e.g. blue eyes, blond hair, fair skin—people of Nordic decent) with genotypes. In addition, environmental factors such as diet, work, or smoking habit may be related as well.
  • [0075]
    The system and method further utilize a drug utilization review (“DUR”), incorporating the genomic dimension to the patient specific DUR. DUR application uses the link among the three elements discussed above, drug reactions and genotype, to create methods for avoiding ADRs for a given patient. With the knowledge of the genomic drug safety database, there is an established association of certain SNPs and gene variants of an individual that are associated with a drug and its reactions. By having background tested, or through an understanding of a person's genotype or phenotype from clinical evidence (for example, a person who does not metabolize and respond to fluoxetine can be presumed to poorly metabolize CYP (2D6) related drugs. If the database shows certain ADRs with such a person, the DUR application of the database would assess the drug and rate its potential for adverse reactions for that individual. Other factors, such as environment, nutrition, foodstuffs, beverages, exposure to toxins, chemicals, supplements, herbal remedies, and the use of other drugs, would also continue to be considered, based on the best available evidence.
  • [0076]
    To formulate risk of drug safety, the system and method assign a risk parameter that combines drug, genetic, and outcome information of drugs on the drug label, to create a rapid means to improve drugs for an individual patient, or assess the risk of a specific drug for that patient.
  • [0077]
    The system may assign a PIN to an individual, and then provide a means by which to query the database on the relative risk for a drug, as described below. By using a PIN based system, there is provided the maintenance of privacy.
  • [0078]
    The method and system described herein may be embodied in a network environment. Such an implementation enables the DUR application in a web-based system, where a central (or other network accessible means) is used to allow access to the check of drugs from any location. A subscriber would be provided the information in the background. Others would enter the PIN and drug and the resulting assessment of the risk would be returned. As a means for universal understanding of the results, a scale could be used (such as described below). This method would allow any subscriber or enrollee to a healthcare program using the method to input genomic data from any location, for example, a genomics lab that examines the patient, or enrollees profile. The data on other aspects of the patient would similarly be entered, all via PIN. Then, at any time, the DUR application would allow network access to the risk assessment.
  • [0079]
    The present method may use a parameter or coefficient specifically designed to measure risk. Although many weightings may be used, this parameter would provide, on a suitable scale (e.g., 0 to 1.0 or other normalized scale), a weighted assessment of genetic risk for the patient based on the probability that certain drug reactions are likely for the patient genotype. The scale takes into account the closeness of the drug to the drug in the database (it could only share chemical class) and the closeness of the genetic profile of the patient to the average genetic profile of the database, again using a closeness fraction based on the number of standard deviations from the mean fit. This scale would then provide a nominal risk, with an error range, for the individual. Any actual scale that uses a linear, or logarithmic weighting (or other), that accounts for a closeness adjustment for the drug and for the genotype, will then be used to report the expected ADRs. Note, in the preferred embodiment, the most serious reaction would be used and weighted more heavily (using, for example, the FDA CDER Designated Medical Event list).
  • [0080]
    The scale would be refined over time as better tests and more population statistics are added. Thus, both the database and the precision of the scale will improve over time. The use of a numerical range that healthcare providers become accustomed to will allow ease of interpretation of the results.
  • [0081]
    The method described herein provides for personalized medicine application in drug safety. The system and method draw a relationship between genetic type and predispositions to adverse reactions for certain drugs or drug types. Given a sufficient set of specific genetic information on an individual, there exists the potential to create a “profile” for that individual.
  • [0082]
    Unlike the relationship of genetic information to diseases, where only a few genes, or SNPs may be involved, the realm of adverse events involves numerous other areas of an individual's metabolism. In fact, it goes beyond that to include the influence of environmental factors such as coffee drinker, smoker, traveler, etc., that changes an individual's environment and medical situation into which drugs are prescribed. The system and method allow, for example, an individual's profile to be privately stored and accessed via a PIN. Then, given the drug a physician is considering, the patient's background can be checked for potential risk.
  • [0083]
    As disclosed herein above, various embodiments of the system and method provide several benefits. These benefits include warning a patient or physician that certain drugs have produced reactions associated with the patient's genotype; a broad understanding of gene and SNP relationships to pathways, proteome and drugs in those pathways; a statistical understanding of the genetic behavior of drug classes; a structural database that allows a drill-down on genetic differences for more specific reactions; a database that makes ADR profile associations with proteome possible; a database that increases the potential to uncover the multiple ways certain ADRs could develop; a method for scoring the genomic based risk of certain adverse events for drugs or drug classes; a method for preserving patient privacy while permitting clinical labs, physicians, etc., to access the information for a particular patient; adjustment of the genetic risk by correlation with environmental factors; a method for adding details to the genomic database as new information is made available; a broad, statistical understanding of population genetic impact on the percentage risk of certain adverse events with certain drugs or drug classes; and a method for adding data from sources that may have been based on different vocabularies.
  • [0084]
    Although the present invention has been described and illustrated in detail, it is to be clearly understood that the same is by way of illustration and example only, and is not to be taken as a limitation. The spirit and scope of the present invention are to be limited only by the terms of any claims presented hereinafter.
Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US4384329 *19 Dic 198017 May 1983International Business Machines CorporationRetrieval of related linked linguistic expressions including synonyms and antonyms
US5299121 *4 Jun 199229 Mar 1994Medscreen, Inc.Non-prescription drug medication screening system
US5337919 *11 Feb 199316 Ago 1994Dispensing Technologies, Inc.Automatic dispensing system for prescriptions and the like
US5371807 *20 Mar 19926 Dic 1994Digital Equipment CorporationMethod and apparatus for text classification
US5495604 *25 Ago 199327 Feb 1996Asymetrix CorporationMethod and apparatus for the modeling and query of database structures using natural language-like constructs
US5502576 *24 Ago 199226 Mar 1996Ramsay International CorporationMethod and apparatus for the transmission, storage, and retrieval of documents in an electronic domain
US5583758 *7 Jun 199510 Dic 1996Health Risk Management, Inc.Health care management system for managing medical treatments and comparing user-proposed and recommended resources required for treatment
US5592668 *6 Jun 19957 Ene 1997Asymetrix CorporationMethod and apparatus for specifying a query to an information system using natural language-like constructs
US5594637 *26 May 199314 Ene 1997Base Ten Systems, Inc.System and method for assessing medical risk
US5634053 *29 Ago 199527 May 1997Hughes Aircraft CompanyFederated information management (FIM) system and method for providing data site filtering and translation for heterogeneous databases
US5642731 *2 Dic 19941 Jul 1997Informedix, Inc.Method of and apparatus for monitoring the management of disease
US5659731 *19 Jun 199519 Ago 1997Dun & Bradstreet, Inc.Method for rating a match for a given entity found in a list of entities
US5664109 *7 Jun 19952 Sep 1997E-Systems, Inc.Method for extracting pre-defined data items from medical service records generated by health care providers
US5692171 *27 Mar 199625 Nov 1997Bull S.A.Method of extracting statistical profiles, and use of the statistics created by the method
US5737539 *28 Oct 19947 Abr 1998Advanced Health Med-E-Systems Corp.Prescription creation system
US5758095 *24 Feb 199526 May 1998Albaum; DavidInteractive medication ordering system
US5804803 *2 Abr 19968 Sep 1998International Business Machines CorporationMechanism for retrieving information using data encoded on an object
US5833599 *8 Abr 199610 Nov 1998Multum Information ServicesProviding patient-specific drug information
US5845255 *2 Oct 19971 Dic 1998Advanced Health Med-E-Systems CorporationPrescription management system
US5860917 *15 Ene 199719 Ene 1999Chiron CorporationMethod and apparatus for predicting therapeutic outcomes
US5864789 *24 Jun 199626 Ene 1999Apple Computer, Inc.System and method for creating pattern-recognizing computer structures from example text
US5911132 *14 Oct 19978 Jun 1999Lucent Technologies Inc.Method using central epidemiological database
US5924074 *27 Sep 199613 Jul 1999Azron IncorporatedElectronic medical records system
US5978804 *10 Abr 19972 Nov 1999Dietzman; Gregg R.Natural products information system
US5991729 *28 Jun 199723 Nov 1999Barry; James T.Methods for generating patient-specific medical reports
US6000828 *22 Ago 199714 Dic 1999Power Med IncorporatedMethod of improving drug treatment
US6014631 *2 Abr 199811 Ene 2000Merck-Medco Managed Care, LlcComputer implemented patient medication review system and process for the managed care, health care and/or pharmacy industry
US6054268 *21 Oct 199625 Abr 2000Perlin; Mark W.Method and system for genotyping
US6055538 *22 Dic 199725 Abr 2000Hewlett Packard CompanyMethods and system for using web browser to search large collections of documents
US6067524 *7 Ene 199923 May 2000Catalina Marketing International, Inc.Method and system for automatically generating advisory information for pharmacy patients along with normally transmitted data
US6076083 *21 Ago 199613 Jun 2000Baker; MichelleDiagnostic system utilizing a Bayesian network model having link weights updated experimentally
US6076088 *6 Feb 199713 Jun 2000Paik; WoojinInformation extraction system and method using concept relation concept (CRC) triples
US6082776 *7 May 19974 Jul 2000Feinberg; Lawrence E.Storing personal medical information
US6092072 *7 Abr 199818 Jul 2000Lucent Technologies, Inc.Programmed medium for clustering large databases
US6098062 *17 Ene 19971 Ago 2000Janssen; TerryArgument structure hierarchy system and method for facilitating analysis and decision-making processes
US6108635 *30 Abr 199722 Ago 2000Interleukin Genetics, Inc.Integrated disease information system
US6112182 *16 Ene 199629 Ago 2000Healthcare Computer CorporationMethod and apparatus for integrated management of pharmaceutical and healthcare services
US6120443 *8 Abr 199719 Sep 2000Cohen-Laroque; Emmanuel-S.Device for determining the depth of anesthesia
US6128620 *2 Feb 19993 Oct 2000Lemed IncMedical database for litigation
US6137911 *16 Jun 199724 Oct 2000The Dialog Corporation PlcTest classification system and method
US6151581 *16 Dic 199721 Nov 2000Pulsegroup Inc.System for and method of collecting and populating a database with physician/patient data for processing to improve practice quality and healthcare delivery
US6188988 *10 Mar 200013 Feb 2001Triangle Pharmaceuticals, Inc.Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens
US6209004 *28 Ago 199627 Mar 2001Taylor Microtechnology Inc.Method and system for generating and distributing document sets using a relational database
US6219674 *24 Nov 199917 Abr 2001Classen Immunotherapies, Inc.System for creating and managing proprietary product data
US6226564 *1 Nov 19961 May 2001John C. StuartMethod and apparatus for dispensing drugs to prevent inadvertent administration of incorrect drug to patient
US6246975 *30 Oct 199712 Jun 2001American Board Of Family Practice, Inc.Computer architecture and process of patient generation, evolution, and simulation for computer based testing system
US6253169 *28 May 199826 Jun 2001International Business Machines CorporationMethod for improvement accuracy of decision tree based text categorization
US6263329 *3 Sep 199917 Jul 2001ClaritechMethod and apparatus for cross-linguistic database retrieval
US6273854 *5 May 199814 Ago 2001Body Bio CorporationMedical diagnostic analysis method and system
US6317719 *10 Nov 199813 Nov 2001Cerner Mulium, Inc.Providing patient-specific drug information
US6331138 *27 May 199818 Dic 2001Holland Industriele Diamantwerken B.V.Grinding machine
US6421665 *1 Oct 199916 Jul 2002Ncr CorporationSQL-based data reduction techniques for delivering data to analytic tools
US6446081 *16 Dic 19983 Sep 2002British Telecommunications Public Limited CompanyData input and retrieval apparatus
US6466923 *29 Abr 199815 Oct 2002Chroma Graphics, Inc.Method and apparatus for biomathematical pattern recognition
US6507829 *17 Ene 200014 Ene 2003Ppd Development, LpTextual data classification method and apparatus
US6542902 *23 Mar 20011 Abr 2003Bridge Medical, Inc.Method and apparatus for displaying medication information
US6578003 *1 May 200010 Jun 2003Schering CorporationMethod and apparatus for improving patient compliance with prescriptions
US6658396 *29 Nov 19992 Dic 2003Tang Sharon SNeural network drug dosage estimation
US6684221 *8 May 200027 Ene 2004Oracle International CorporationUniform hierarchical information classification and mapping system
US6697783 *29 Sep 199824 Feb 2004Medco Health Solutions, Inc.Computer implemented medical integrated decision support system
US6778994 *2 May 200117 Ago 2004Victor GogolakPharmacovigilance database
US6789091 *2 May 20017 Sep 2004Victor GogolakMethod and system for web-based analysis of drug adverse effects
US6876966 *16 Oct 20005 Abr 2005Microsoft CorporationPattern recognition training method and apparatus using inserted noise followed by noise reduction
US6950755 *2 Jul 200127 Sep 2005City Of HopeGenotype pattern recognition and classification
US7461006 *28 Ago 20022 Dic 2008Victor GogolakMethod and system for the analysis and association of patient-specific and population-based genomic data with drug safety adverse event data
US7539684 *20 Feb 200226 May 2009Qed Solutions, Inc.Processing drug data
US7542961 *2 May 20012 Jun 2009Victor GogolakMethod and system for analyzing drug adverse effects
US20010049673 *23 Mar 20016 Dic 2001Bridge Medical, Inc.Method and apparatus for displaying medication information
US20020010595 *2 Abr 200124 Ene 2002Kapp Thomas L.Web-based medication management system
US20020012921 *22 Ene 200131 Ene 2002Stanton Vincent P.Identification of genetic components of drug response
US20020040282 *22 Mar 20014 Abr 2002Bailey Thomas C.Drug monitoring and alerting system
US20020073042 *7 Dic 200013 Jun 2002Maritzen L. MichaelMethod and apparatus for secure wireless interoperability and communication between access devices
US20020082869 *27 Dic 200027 Jun 2002Gateway, Inc.Method and system for providing and updating customized health care information based on an individual's genome
US20020120350 *3 Oct 200129 Ago 2002Klass David B.Method and system for identifying and anticipating adverse drug events
US20020129031 *5 Ene 200112 Sep 2002Lau Lee MinManaging relationships between unique concepts in a database
US20020142815 *8 Dic 20003 Oct 2002Brant CandeloreMethod for creating a user profile through game play
US20020169771 *9 May 200114 Nov 2002Melmon Kenneth L.System & method for facilitating knowledge management
US20020183965 *2 May 20015 Dic 2002Gogolak Victor V.Method for analyzing drug adverse effects employing multivariate statistical analysis
US20020187483 *16 Oct 200112 Dic 2002Cerner CorporationComputer system for providing information about the risk of an atypical clinical event based upon genetic information
US20030040662 *22 Ago 200227 Feb 2003Philip KeysSystem, method and computer program for monitoring and managing medications
US20030124514 *8 Ago 20023 Jul 2003Vingerhoets Johan Hendrika JozefMethods of assessing HIV integrase inhibitor therapy
US20040010511 *11 Jul 200215 Ene 2004Gogolak Victor V.Method and system for drug utilization review
US20040015372 *19 Oct 200122 Ene 2004Harris BergmanMethod and system for processing and aggregating medical information for comparative and statistical analysis
US20040030503 *13 Ago 200212 Feb 2004Scott ArouhNeural -network-based identification, and application, of genomic information practically relevant to diverse biological and sociological problems, including susceptibility to disease
US20090158211 *2 May 200118 Jun 2009Gogolak Victor VMethod for graphically depicting drug adverse effect risks
Otras citas
Referencia
1 *Google patents search result, 11/24/2014
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US79256122 May 200112 Abr 2011Victor GogolakMethod for graphically depicting drug adverse effect risks
US797937322 May 200912 Jul 2011Druglogic, Inc.Method and system for analyzing drug adverse effects
US813176914 May 20096 Mar 2012Druglogic, Inc.Processing drug data
US8799022 *4 May 20125 Ago 2014Strat ID GIC, Inc.Method and network for secure transactions
US96072668 May 201428 Mar 2017Tata Consultancy Services LimitedSystems and methods for signal detection in pharmacovigilance using distributed processing, analysis and representing of the signals in multiple forms
US20090158211 *2 May 200118 Jun 2009Gogolak Victor VMethod for graphically depicting drug adverse effect risks
US20100063830 *10 Sep 200811 Mar 2010Expanse Networks, Inc.Masked Data Provider Selection
US20100138161 *22 May 20093 Jun 2010Victor GogolakMethod and system for analyzing drug adverse effects
US20110161099 *8 Sep 201030 Jun 2011Igor Igorevich StukanovLow-cost method for reducing rates of side effects from using drugs, healing substances and medical procedures
US20120078601 *26 Sep 201129 Mar 2012General Electric CompanyDrug treatment plans derived from holistic analysis
US20120124051 *29 Jul 201017 May 2012Wilfred Wan Kei LinOntological information retrieval system
US20120143776 *7 Dic 20107 Jun 2012Oracle International CorporationPharmacovigilance alert tool
US20140350964 *21 May 201427 Nov 2014Quantros, Inc.Probabilistic event classification systems and methods
CN103336914A *31 May 20132 Oct 2013中国人民解放军国防科学技术大学Method and device for extracting meta biomarkers
Clasificaciones
Clasificación de EE.UU.705/2, 705/7.36
Clasificación internacionalG06Q10/06, G06Q50/22, G06Q50/24, G06F19/24, G06F19/18, G06F19/00, G06F19/28, G06F17/10
Clasificación cooperativaG06F19/18, G06F19/326, G06Q10/0637, G06F19/363, G06F19/3443, G06Q50/24, G06F19/24, G06F19/28, G06Q50/22, Y10S707/99945, Y10S707/99942
Clasificación europeaG06Q50/24, G06Q50/22, G06F19/32E3, G06Q10/0637, G06F19/24