US20090218373A1 - Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein - Google Patents
Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein Download PDFInfo
- Publication number
- US20090218373A1 US20090218373A1 US12/092,689 US9268906A US2009218373A1 US 20090218373 A1 US20090218373 A1 US 20090218373A1 US 9268906 A US9268906 A US 9268906A US 2009218373 A1 US2009218373 A1 US 2009218373A1
- Authority
- US
- United States
- Prior art keywords
- valve assembly
- flowable substance
- delivery system
- way valve
- inner core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
- B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
- B65D47/205—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the valve being formed by a tubular flexible sleeve surrounding a rod-like element provided with at least one radial passageway which is normally closed by the sleeve
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D5/00—Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper
- B65D5/42—Details of containers or of foldable or erectable container blanks
- B65D5/72—Contents-dispensing means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/80—Packaging reuse or recycling, e.g. of multilayer packaging
Abstract
A reusable continuously sealing one-way valve assembly and delivery system flows a sterile flowable substance from a source to an outlet orifice and prevents any backflow of contaminants through the continuously sealing one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped. Multiple dosing of preservative-free flowable substance is provided.
Description
- This application claims priority to U.S. patent application Ser. No. 11/267,868, filed Nov. 3, 2005, and U.S. Provisional Patent Application Ser. No. 60/823,462, filed Aug. 24, 2006, each of which are incorporated by reference herein in their entirety.
- The present invention is directed to a dispensing and delivery system including a continuously sealing one way valve assembly for dispensing a sterile flowable substance, which can include preservatives or be preservative free, while preventing a backflow of contaminants into the source of the flowable substance. The dispensing and delivery system includes, for example, a valve assembly enclosed by a pressure displaceable flexible member or elastomeric member for effecting the passage of the flowable substance to a controllable outlet, while preventing any backflow to the source of the flowable substance after dispensing individual portions or doses of the flowable substance.
- In the past, to maintain the flowable substance free of contaminants, preservatives have been mixed in with the flowable substance in the reservoir from which it is to be dispensed. The use of preservatives tends to be detrimental to users and often limits the effectiveness of the flowable substance, particularly when the flowable substance is a pharmaceutical such as an eye care solution, an intranasal drug, cosmetic treatment or skin treatment product. This group of prescription and nonprescription medications are often formulated with preservatives in multi-dose formats. The flowable substance may also be a food stuff, a beverage, a nutraceutical or cosmeceutical product.
- Another consideration is the ability of the valve assembly to deliver a selected amount of the flowable substance to the outlet without causing any damage to the user, such as when applying an eye care solution directly into the eye.
- In the past, flexible membranes have been used to control the flow of the flowable substance to the valve assembly outlet while preventing any backflow to the source of the flowable substance. However such valves, such as the valve described in U.S. Pat. No. RE34,243, which is incorporated by reference herein in its entirety, describe the use of O-rings in conjunction with a uniformly thick flexible membrane to effect a seal. Other valve assemblies also used cylindrical parts which required, for example, sliding the pretensioned flexible membrane over the straight sided core during assembly, preventing automated high speed assembly. Therefore, an effectively designed valve assembly which was able to be manufactured, for example via high speed automated production, and limited the costs of manufacture by reducing component parts and allowing the use of high speed automated production, was not provided in the past.
- According to an exemplary embodiment of the present invention, a dispensing and delivery system conveys a flowable substance from a closed source, such as a collapsible reservoir, while preventing any backflow of oxygen or other contaminants from the ambient atmosphere through the valve assembly and into the source of the flowable substance after a portion of the substance has been dispensed.
- The collapsible reservoir can be, for example, a bellows type reservoir, a collapsible tube, an internal bag or other type of suitable reservoir designed to dispense practically all of its contents. According to an exemplary embodiment of the present invention, the dispensing delivery system has a normally closed controllable outlet orifice for dispensing a controlled amount of the flowable substance out of the valve assembly. The reservoir is in sealed contact with the valve assembly so that its contents do not receive any contaminants when the flowable substance is dispensed.
- Dispensation of the flowable substance is effected by applying pressure to a reservoir directly or through a pump so that its contents flow to and through the valve assembly. The contents may be, for example, a pharmaceutical, such as an eye care solution or other substance which is to be kept free of contaminants during dispensing. According to an exemplary embodiment of the present invention, a multiple number of dispensed amounts can be provided while keeping the undispensed flowable substance preservative-free. Other flowable substances which are preservative-free can be food stuffs, juices or beverages, cosmetics, or other flowable substances intended to be maintained free of preservatives and contaminants, notwithstanding multiple uses of the dispenser delivery system. The flowable substance reservoir is protected by a housing so that pressure is not accidentally applied.
- The valve assembly includes, for example, an axially extending structure open to the dispenser or reservoir of the flowable substance. The valve assembly can be formed of an axially extending inner core open to the reservoir and formed of a rigid plastic component. The interior of the core can have a passageway for receiving the flowable substance from the reservoir. At least one port extending from the passageway can be provided and affords an opening for conveying the flow substance out of the inner core. The inner core can be designed with a substantially tapered or substantially conical shape.
- An axially extending flexible membrane tightly encloses the inner core and covers the outlet end of the port through the inner core. The flexible membrane moves outwardly from the inner core when the flowable substance is pressurized and passes through the port and flows toward the outlet end of the flexible membrane. The flexible membrane is structured such that it is, for example, thicker at the end closest to the valve opening, e.g. the flexible membrane is not uniformly thick along its length. This thickness allows the valve to seal at the thicker end first. Alternatively, even if the membrane was of uniform thickness, the elasticity of the membrane can be varied so that the portion of the membrane closest to the valve opening is less elastic, resulting in the portion of the membrane closest to the valve opening closing first.
- In exemplary embodiments, the flexible membrane and, as described above, the inner core, are of a substantially tapered or substantially conical shape, allowing for the rapid assembly and natural resting of the flexible membrane over the inner core.
- A valve cover located laterally outwardly from the flexible membrane ends at the controllable outlet orifice. The pressurized flowable substance travels between the radially outwardly extended flexible membrane and the outer surface of the inner core and flows to the controllable outlet orifice. The outlet orifice provides for controlled amounts of the flowable substance to be dispensed. An over cap covers the exterior of the valve cover to protect the valve assembly during storage. A collar can join the valve assembly to the reservoir and afford a sealed arrangement preventing any flow of contaminants into the reservoir. The collar and the neck area of the reservoir are designed with locking features that permit the override of the collar during assembly but subsequently prevent the unscrewing and disassembly of the collar and the opening of and likely contamination of the system.
- The various features of novelty which characterize the present invention are pointed out with particularity in the claims annexed to and forming a part of this disclosure. For a better understanding of the present invention, its operation, advantages and specific objects attained by its use, reference should be had to the accompanying drawings and descriptive matter in which preferred embodiments of the invention are illustrated and described.
-
FIG. 1 is an axially extending view of a dispensing and delivery system according to an exemplary embodiment of the present invention. -
FIG. 2A is an exploded view of a dispensing and delivery system such as that shown inFIG. 1 according to an exemplary embodiment of the present invention. -
FIG. 2B is an exploded view of a dispensing and delivery system such as that shown inFIG. 1 according to an exemplary embodiment of the present invention which includes a pump for dispensing flowable substance. -
FIG. 3 is an exploded view of the soft cover and its controllable outlet orifice according to an exemplary embodiment of the present invention wherein the controllable outlet orifice is a cross slit. -
FIG. 4A is an enlarged axially extending partial view of the continuously sealing one way valve assembly with a flat topped soft cover according to an exemplary embodiment of the present invention. -
FIG. 4B is an enlarged axially extending partial view of the continuously sealing one way valve assembly with a rounded soft cover according to an exemplary embodiment of the present invention wherein the continuously sealing one way valve assembly is in the rest position. -
FIG. 4C is an enlarged axially extending partial view of the continuously sealing one way valve assembly with a rounded soft cover according to an exemplary embodiment of the present invention wherein the continuously sealing one way valve assembly is in the dispensing position. -
FIG. 4D is an enlarged axially extending partial view of the continuously sealing one way valve assembly where the opening in the soft cover contains a portion of the flexible membrane and inner core of the valve assembly according to an exemplary embodiment of the present invention. -
FIG. 5 is an enlarged partial axially extending view of the continuously sealing one way valve assembly shown inFIGS. 4B and 4C according to an exemplary embodiment of the present invention. -
FIG. 6A is an axially extending partial view of the continuously sealing one way valve assembly with one port and an outlet port according to an exemplary embodiment of the present invention. -
FIG. 6B is an enlarged axially extending partial view of the continuously sealing one way valve assembly with one port and an outlet port according to an exemplary embodiment of the present invention. - As shown in
FIGS. 1 , 2A and 2B, dispensing anddelivery system 1 according to exemplary embodiments of the present invention is comprised of a bellows reservoir orsource 2 located within ahousing 6. Thehousing 6 and holdsreservoir 2 of flowable substance, preferably a sterile or pure flowable substance, a valve assembly 3 (shown in detail inFIGS. 2A , 2B and 4A-D) for conveying the flowable substance from thereservoir 2 to an outlet when pressure is applied to thereservoir 2 or to anactuator 2 a connected to thereservoir 2. An overcap 15 covers thevalve assembly 3 to prevent contamination from entering thevalve assembly 3 during storage. Thehousing 6 hassurfaces 6 a for holding the assembly. Acollar 8 connects thevalve assembly 3 to thereservoir 2 affording a sealed connection so that ambient contaminants cannot pass into thereservoir 2. - Referring again to
FIGS. 1 , 2A and 2B, thebellows reservoir 2 is sufficiently large to allow for multiple doses to be dispensed from the reservoir and collapses when pressure is applied to the reservoir. Other suitable reservoirs may be used, such as a collapsible tube or an internal bag in a reservoir that permit multi-dose dispensation of the flowable substance. Thevalve assembly 3 andcollar 8 preferably prevents air or other contamination from entering the reservoir following the dispensing procedure. - Referring yet again to
FIGS. 1 , 2A and 2B, the bellows reservoir orsource 2 is laterally enclosed, for example, by anaxially extending housing 6 to prevent the accidental application of pressure to the reservoir. Aslot 6 b extending axially in thehousing 6 permits a user to gain access to anactuator 2 a of the reservoir as the flowable substance is pressed out. Thehousing 6 hassurfaces 6 a for holding the housing when the flowable substance is being dispensed. - Referring now to
FIGS. 2A and 2B , thevalve assembly 3 hasvalve cover 14 which encircles theflexible membrane 13. Thevalve assembly 3 is comprised of aninner core 10, an axially extendingblind passageway 11,ports 12, aflexible membrane 13, avalve cover 14 with aflange 14 a, and asoft cover 7 with acontrollable outlet orifice 7 a (all of which are described in greater detail below in connection with the descriptions ofFIGS. 4A-D ). While theflexible membrane 13 is hollow so as to accommodate theinner core 10, it is understood that when assembled with the device, it is filled with theinner core 10 such that no gap remains when the valve assembly is at rest. - The end of the
valve cover 14 adjacent thereservoir 2 has a radially outwardly extendingflange 14 a bearing against the flange at the end of the flexible membrane effecting the seal for the valve assembly at the opening from thereservoir 2. The opening or neck area ofreservoir 2 seals againstflange 14 a, for example, by way of a screw thread which mates with thecollar 8. Alternatively, or in addition, thecollar 8 and the opening or neck area of thereservoir 2 are designed with locking features that permit the override of thecollar 8 during assembly but subsequently prevent the unscrewing and disassembly of thecollar 8 and the opening of the system. This prevents any unintended contamination by the consumer and also eliminates the possibility of refilling the system. - Referring now especially to
FIG. 2B , in an embodiment suitable for pumping flowable substance, apump assembly 16 is joined to avalve assembly 3 a and to areservoir 2 andbottle 6 b. Thecollar 8 surrounds the connection between thepump assembly 16 andvalve assembly 3 a. Thepump assembly 16 is connected to thebottle 6 by screw threads. The opening or neck area ofbottle 6 seals againstpump assembly 16, for example, by way of a screw thread which mates with thepump assembly 16 sealingflange 2 c ofreservoir 2 between thebottle 6 and thepump assembly 16. Alternatively, or in addition, thecollar 8 and the opening or neck area of thereservoir 2 are designed with locking features that permit the override of thepump assembly 16 during assembly but subsequently prevent the unscrewing and disassembly of thepump assembly 16 and the opening of the system. This prevents any unintended contamination by the consumer and also eliminates the possibility of refilling the system. - The
pump assembly 16 is thus connected to avalve assembly 3 a having anactuator 17, aninner core 10, an axially extendingblind passageway 11,ports 12, aflexible membrane 13, avalve cover 14 with aflange 14 a, and asoft cover 7 with acontrollable outlet orifice 7 a (further described below in connection with the descriptions ofFIGS. 4A-D ). Optionally, theactuator 17 may be connected to or include an atomizer. In operation theactuator 17 serves to transfer force via a check valve of thepump assembly 16 to draw flowable substance from thereservoir 2, thus providing the force necessary to dispense flowable substance. For example, conventional pumps may be utilized in this manner. - Furthermore, the
reservoir 2 can be disposed within abottle 6 whose open end is sealed by aplug 2 c.Plug 2 c serves to protect thereservoir 2 from damage, rupture or inadvertent application of force on thereservoir 2. - Referring now to
FIG. 3 , thecontrollable outlet orifice 7 a is a cross-slit enabling substantially dripless dispensing of the flowable substance. The cross-slit causes thecontrollable outlet orifice 7 a to self close on itself after pressure is released. - The
controllable outlet orifice 7 a can be formed as desired to provide a spray or a stream of the flowable substance. Alternatively, by selectively dimensioning thecontrollable outlet orifice 7 a, a drop-like amount of the flowable substance can be dispensed, for example if an eye care solution is being dispensed. If a greater amount of the flowable substance is to be dispensed, thecontrollable outlet orifice 7 a can be formed for dispensing a larger quantity of the flowable substance, for example, a eye or nasal solution and/or gel. - Referring now to
FIGS. 4A-D , thevalve assembly 3 preferably has aninner core 10, an axially extendingblind passageway 11,ports 12, aflexible membrane 13, avalve cover 14 with aflange 14 a, and asoft cover 7 with acontrollable outlet orifice 7 a. An overcap 15 is placed over thevalve assembly 3 when it is not in use, protecting it from contact with ambient contaminants. - In the
valve assembly 3, an axially extendinginner core 10 bears against the opening of thereservoir 2 so that flow from the reservoir enters into an axially extendingblind passageway 11 in the inner core. Thepassageway 11 extends for a major portion of the axial length of the inner core. At approximately half the length of thepassageway 11, the inner core has a pair ofports 12 extending transversely of the passageway axis from the surface of the passageway to the outer surface of theinner core 10. Theinner core 10 is formed of, for example, a rigid plastic material and terminates inwardly of the outlet end of the valve assembly. Furthermore, in exemplary embodiments, upon assembly and filling of the assembly no air is present inside thepassageway 11 and theports 12. It should be noted thatadditional ports 12 may be located through theinner core 10. - Furthermore, in exemplary embodiments the
inner core 10 and theflexible membrane 13 are constructed such that they fit tightly together, for example having very close tolerances which allow for an air-tight seal to be formed between theflexible membrane 13 and theinner core 10. In further exemplary embodiments the molding process for theflexible membrane 13 and theinner core 10, as well as other components described above as sealing against one another is an asymmetric molding process which creates a surface substantially free of defects or seam lines at the areas of contact where sealing occurs. Accordingly, in an exemplary embodiment, very close tolerances between the parts, for example theinner core 10 andflexible membrane 13 and the other parts, are used to provide an optimal seal and operation of the valve assembly. - A
flexible membrane 13, such as an elastomeric member, is fitted tightly over the outer surface of the inner core and extends from the opening in thereservoir 2 to the opposite end of theinner core 10. As can be noted inFIGS. 4A-D , the thickness of the membrane is preferably variable along its axial length. In the region of the outlet end of the inner core has, for example, an axially extending continuous uninterrupted end considerably thicker than the remainder of theflexible membrane 13. That is, the band is not separated in the axial direction by axially extending cuts. The thicker end ensures that after the valve has dispensed fluid, as further described below, the valve closes at the end closest to theopening 7 a first, therefore preventing any backflow. This is effected by the heavy wall thickness which provides for greater tension. As a result, theflexible membrane 13 exhibits non-uniform tension. - In a further example, in yet other embodiments, the thickness of the membrane may be variable along its axial length and the region surrounding the outlet end of the inner core has, for example, an axially extending continuous uninterrupted annular band considerably thicker than the remainder of the
flexible membrane 13. Furthermore, in certain embodiments, the band is not separated in the axial direction by axially extending cuts. Alternatively, the elasticity or durometer of the end of the flexible membrane closest to the valve opening may be varied, for example it may be reduced, such that the end closest to the valve opening seals first when pressure is relieved. - In a further embodiment,
flexible membrane 13 andinner core 10 are substantially tapered or substantially conical at the ends closest to thecontrollable outlet orifice 7 a such that theinner core 10 nest into theflexible membrane 13 one another when being assembled by high speed automated production equipment. - At its end adjacent to the opening of the
reservoir 2, theflexible membrane 13 has an outwardly extending flange bearing against a flange on the inner core located at the opening from the reservoir. - An axially extending
valve cover 14 encircles theflexible membrane 13 and, as shown in the rest position inFIG. 2 a, is spaced radially outwardly from the outer surface of the flexible membrane. The end of thevalve cover 14 adjacent thereservoir 2 has a radially outwardly extendingflange 14 a bearing against the flange at the end of the flexible membrane effecting the seal for the valve assembly at the opening from thereservoir 2. - The
valve cover 14 is formed, for example, of an inner layer of an elastomeric material extending axially from itsflange 14 a to and over the outlet end of thevalve assembly 3. Elastomeric material forms asoft cover 7 over the outlet end of thevalve cover 14 which is particularly advantageous when the valve assembly is used for dispensing an eye care solution. Such asoft cover 7 prevents, for example, any likelihood of harm to the delicate outer surfaces of the eye or surrounding tissue. Thesoft cover 7 has acontrollable outlet orifice 7 a for dispensing the flowable substance. The outlet orifice is closed in the rest position of the continuously sealing one way valve assembly and open in the dispensing position. - Referring yet again to
FIGS. 4A-D and toFIG. 5 , various embodiments of thevalve assembly 3 are depicted having variations in the structure of thesoft cover 7 as described below. - Referring now especially to
FIG. 4A , a valve assembly having a flat toppedsoft cover 7 is provided. Thesoft cover 7 has a flattened top, which allows for less flowable substance to adhere to thecontrollable outlet orifice 7 a because the flattened top results in a shortercontrollable outlet orifice 7 a. Thesoft cover 7 has acontrollable outlet orifice 7 a which can be formed as desired to provide a spray or a stream of the flowable substance. Furthermore, thecontrollable outlet orifice 7 a can be a cross-slit as shown inFIG. 3 . Alternatively, by selectively dimensioning thecontrollable outlet orifice 7 a, a drop-like amount of the flowable substance can be dispensed, for example if an eye care solution or other solution typically delivered in droplet form, is being dispensed. If a greater amount of the flowable substance is to be dispensed, thecontrollable outlet orifice 7 a can be formed for dispensing a larger quantity of the flowable substance, for example by having a larger diameter opening. - Referring now especially to
FIGS. 4B-C , a valve assembly having a roundedsoft cover 7 is provided. Thesoft cover 7 has a rounded top useful for dispensing flowable substance into the outer surfaces of the eye and surrounding tissue or other sensitive body areas. Because the rounded tip lacks sharp edges, damage to the eye or other sensitive tissues is avoided or reduced if incidental contact occurs during administration of the flowable substance. Thesoft cover 7 has acontrollable outlet orifice 7 a which can be formed as desired to provide a spray or a stream of the flowable substance. Furthermore, thecontrollable outlet orifice 7 a can be a cross-slit as shown inFIG. 3 . Alternatively, by selectively dimensioning thecontrollable outlet orifice 7 a, a drop-like amount of the flowable substance can be dispensed, for example if an eye care solution or other solution typically delivered in droplet form, is being dispensed. If a greater amount of the flowable substance is to be dispensed, thecontrollable outlet orifice 7 a can be formed for dispensing a larger quantity of the flowable substance, for example by having a larger diameter opening. - Referring now especially to
FIG. 4D , a valve assembly having aflat cover 7 which has an enlarged version ofcontrollable outlet orifice 7 a is provided. The enlarged version ofcontrollable outlet orifice 7 a is able to accommodate theinner core 10 andflexible membrane 13 and is suitable for dispensing viscous flowable substances such as lotions, creams and emollients, but may also be used for any flowable substance. The enlarged version ofcontrollable outlet orifice 7 a allows flowable substance to be dispensed without having to move through two openings—namely the opening at the end of theflexible elastomer 13 and thecontrollable outlet orifice 7 a, since these are now flush. - Referring now to
FIG. 5 the gap formed betweeninner core 10 and theflexible membrane 13 by the pressurized fluid flowing out ofports 12 can more easily be seen. Thecontrollable outlet orifice 7 a insoft cover 7 can also be seen and may for example be a substantially uniform circular bore thought the material ofsoft cover 7 or may be suitably dimensioned as described in the preceding paragraphs. - Referring now to
FIGS. 6A-B , in another embodiment, flowable substance flows through asingle port 12 ininner core 10 and expands theflexible membrane 13, swirling around the exterior ofinner core 10, and exiting via anoutlet port 12 a as shown inFIGS. 6A and 6B . This results in the need for less cracking pressure to dispense flowable substance and is particularly advantageous for use with, though not limited to, flowable substances having higher viscosities such as lotions, creams and emollients. It should be noted thatadditional ports 12 may be located through theinner core 10. - In exemplary operation, when the flowable substance is to be dispensed, the over
cap 15 is removed and pressure is applied to theactuator 2 a of thereservoir 2 so that an amount of the flowable substance passes out of the reservoir into thepassageway 11 in theinner core 10. The substance flows through theports 12 and expands theflexible membrane 13 radially outwardly and flows toward the outlet end of the flexible membrane where it exits from the flexible membrane radially inwardly into thecontrollable outlet orifice 7 a in the cover and is dispensed. - When the flowable substance is being dispensed and exits the outlet end of the flexible membrane, it flows radially inward to the
controllable outlet orifice 7 a which then opens allowing the substance to flow out of the valve assembly. When the flowable substance is dispensed and pressure on the source is withdrawn thecontrollable outlet orifice 7 a closes blocking any backflow into the valve assembly. An overcap 15 is placed over thevalve assembly 3 when it is not in use, protecting it from contact with ambient contaminants. - In another embodiment, as depicted in
FIGS. 6A and 6B for example, flowable substance flows through asingle port 12 ininner core 10 and expands theflexible membrane 13, swirling around the exterior ofinner core 10, and exiting via anoutlet port 12 a as shown inFIGS. 6A and 6B . This results in the need for less cracking pressure to dispense flowable substance and is particularly advantageous for use with, though not limited to, flowable substances having higher viscosities such as creams and emollients. - By releasing the pressure on the
actuator 2 a of the reservoir, the dispensing operation is terminated and theflexible membrane 13 returns inwardly into contact with the outer surface of theinner core 10. The inward movement of the flexible membrane starts at its outlet end because of its increased thickness and affords gradual contact with the outer surface of the inner core, returning any flowable substance through the ports back into the reservoir whereby contaminants cannot enter the reservoir. Dispensing individual portions of the flowable substance can be continued until the reservoir is almost completely emptied. As a result of the structure and operation of the valve assembly, the valve assembly according to an exemplary embodiment of the present invention provides uniform pressure on the valve components via the pressurization of the flowable substance. - In still another exemplary embodiment, for example a spray pump such as that depicted in
FIG. 2B , anactuator 17 serves to transfer force to thepump assembly 16 when it is depressed. This in turn compress thereservoir 2, thus providing the force necessary to open the valve assembly and in certain embodiments described above,controllable outlet port 7 a, to dispense flowable substance. - Elastomers suitable to form the
soft cover 7, theflexible membrane 13 and thevalve cover 14 in exemplary embodiments of the present invention include thermoplastic elastomers such as Dynaflex manufactured by GLS Corp., C-Flex manufactured by CPT Inc., or Santoprene manufactured by Advanced Elastomer Systems, Inc. The elastomers, and the materials comprising any of the other components of the device may have integrated, impregnated, otherwise placed within them anti-microbial ingredients such as silver ions contained within a ceramic carrier, such as those supplied by AgION, or sustained-release ionic silver compounds, such as those supplied by Westlake Plastic Technologies which are known to be used in the making of anti-microbial plastics. Furthermore, other anti-microbial suitable for compounding with or coating plastics may be used. Furthermore, thesoft cover 7 or theflexible membrane 13 or both could, for example, be positively charged to repel residual flowable substance, coated in for example, Teflon type-plastics, have increased surface tension or be anti-wetting, or any combination of the above so as to repel flowable substance. - In yet other embodiments, including those described above, the durometer of the elastomers can be varied in relation to the viscosity of the flowable substance. For example, assemblies containing substances with comparatively higher viscosities would utilize softer, i.e. lower durometer elastomers, in order to reduce the cracking force needed to dispense flowable substance, whereas lower viscosity flowable substances would utilized harder, i.e. higher durometer elastomers to maintain a strong seal. Likewise, flowable substances containing lubricants would also utilize harder, i.e. higher durometer elastomers to maintain a strong seal.
- As described above, the parts of the dispensing and delivery device, including the valve assembly may be manufactured to close tolerances such that they form airtight seals and are close fitting ensuring optimal seals and operation of the device.
- A variety of pharmaceuticals, cosmetics, food stuffs and other flowable materials can be dispensed where it is important to maintain them free of contaminants from the ambient atmosphere. The flowable characteristics of the material being dispensed determines or at least may affect the type and dimension of the valve assembly.
- According to exemplary embodiments of the present invention, the material forming the
controllable outlet orifice 7 a does not absorb the flowable substance. As a result, any substance entering theoutlet orifice 7 is ejected from the dispenser and does not return into the space between the inner core and the flexible membrane, thereby maintaining the purity or sterility of the product remaining in the reservoir. - It should be understood that the various embodiments of the valve assembly described above can each be used in the various embodiments of the continuously sealing one way valve assembly device.
- As mentioned, the flowable substance may be a pharmaceutical cosmeceutical, or nutraceautical, an eye care solution, other opthalmological product, otorhinolarygology product, dermatological product, gynecological product, or product for treating or preventing anorectal, dermatological or pulmonary disorders or any formulation administered to the body through the mucus membranes; a food stuff, such as dairy products, beverages or juices; a cosmetic, such as a skin care solution or toiletries; and liquid vitamins, all of which are intended to be maintained free of contaminants from the ambient atmosphere and of preservatives during storage within the
reservoir 2. - According to exemplary embodiments of the present invention, many existing commercial products that contain preservatives can be reformulated into preservative free versions and provided for multiple dose dispensing with the valve assembly and delivery system of the present invention. For example, conventional creams, emollients, eye drops, nasal sprays, cosmetic creams that currently require preservatives, notably parabens and benzalkonium chloride that have proved to be deleterious to tissue, may be reformulated in a preservative free form and are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. This can be accomplished by, for example, formulating the product according to its original formulation, but without the preservative, or by readjusting the formulation of the product, for example by changing the excipients or the amount of the excipients or both. Thus, these preservative free products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention because they are preservative free formulations.
- The following examples provide embodiments describing categories of medical products which are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. Preservative-free storage and delivery of formulations also can be accomplished by providing, for example, multi-dose metered, high barrier and for preservative-free systems as described in U.S. Pat. No. RE 34,243, incorporated by reference above and U.S. Pat. Nos. 5,092,855; 5,305,783; 5,279,447; 5,305,786; and 5,353,961 all of which are hereby incorporated by reference in their entirety.
- In an exemplary embodiment, preservative free opthalmological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. For example, eye drops, and preferably those eye drops involved in chronic care, for example, dry eye, glaucoma, allergies and NSAIDs, and also those eye drops intended for acute care, for example during ocular surgery, are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. As a further example, those eye drops used to relieve eye fatigue, those eye drops used to relieve dry eye, those eye drops used relieve dry eye due to computer use, television use, or fatigue due to prolonged awake periods are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
- Examples of dry eye products can include dry eye products comprising methycellulose, hyaluronic acid, polyethelene glycol 400 0.4%, propylene glycol 0.3%, glycerin, and mineral oils. Examples of glaucoma products include glaucoma products comprising timolol 0.25%/0.50%, brimonidine tartrate 0.1%, bimatoprost 0.03% and travaprost 0.004%. Examples of allergy products include allergy products comprising olopatadine HCL 0.1% and
predisalone acetate 1%. Examples of NSAID products include NSAID products comprising ketorolac 0.5% and diclofenac 0.1%. - In an exemplary embodiment, preservative-free otorhinolarygological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. For example, nasalia medicines, and preferably nasal sprays, external ear creams, ear drops, steroid ear drops, antibiotic ear drops, nose drops, and nose drops comprising phenylephrine 0.25% and pseudoephedrine 30 mg, are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
- In an exemplary embodiment, preservative free dermatological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. For example, preservative free skin preparations; scalp preparations; corticosteroid creams, lotions and ointments; topical antibiotics and topical anti-fungal agents are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. Thus, these preservative free dermatological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention because they are preservative free formulations.
- In an exemplary embodiment, preservative free products for the treatment or prevention of dermatologic disorders are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. For example, preservative free skin preparations; scalp preparations; corticosteroid creams, lotions and ointments; topical antibiotics; topical anti-fungal agents; therapeutic skin creams including anti-bacterial, anti-fungal/parasitic, allergic and non-specific dermatitis creams and emollients and all cosmetic dermatologic compounds used for dermatologic disorders are amendable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
- In an exemplary embodiment, products for the treatment or prevention of anorectal disorders are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. For example, preservative free creams, topical anaesthetics, lubricating jellies and jelly or other preparations for hemorrhoid treatment, prevention or management, are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
- In an exemplary embodiment, preservative free products for the treatment or prevention of pulmonary disorders are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. For example preservative free formulations of products for chronic obstruction disorder, for example, aerosol nebulizers using B-adrenergic, anticholinergic, corticosteroid and theophyline derivatives requiring multi-dose application are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
- In an exemplary embodiment, preservative free gynecological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. For example, vulvovaginal treatment medicines, such as medicines for contact irritant or allergic vulvitis, chemical irritation, bacterial vaginosis, Candidal vaginitis therapy including all azoles and nystatins, butoconazole, butoconalzole 2%, clotrimazole,
clotrimazole 1%, metronidazole and trichomonas treatments are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention. - In an exemplary embodiment, preservative free lens care products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly described herein. For example, contact lens rinsing, cleaning disinfecting and storage solutions, or a multi-purpose solution encompassing contact lens rinsing, cleaning disinfecting and storage are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
- In an exemplary embodiment, preservative free eye wash products (e.g. irrigation solutions) are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly described herein. For example, eye wash products used to clear the eye of environmental contamination are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly described herein. As a further example, eye wash products used to clear the eye of environmental contamination such as pollen or dirt are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
- Although the system is designed for use with various preservative free formulations it may also be used with formulations which are not preservative free.
Claims (42)
1. A continuously sealing one way valve assembly and delivery system for dispensing a flowable substance, comprising:
a source for storage of the flowable substance, the source having an opening;
a valve assembly coupled to the opening of the source, said valve assembly including
(i) an inner core having an inlet opening for receiving the flowable substance into a passageway and at least one port opening from the passageway,
(ii) a hollow flexible membrane having a first end and a second end, the first end being thicker than the second end, wherein the hollow flexible membrane is fitted over an outer surface of the inner core and when the flowable substance is placed under pressure the flowable substance exits through the at least one port opening and expands said membrane outwardly from said outer surface of said inner core;
a cover enclosing the flexible membrane and having an outlet orifice for dispensing the flowable substance from the valve assembly when pressure is applied to the flowable substance and
wherein when the pressure on the flowable substance is released, the first end of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of the inner core before the remainder of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of said inner core.
2. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein the hollow flexible membrane has an axially extending uninterrupted continuous band at the first end of the hollow flexible membrane adjacent the outlet orifice in the cover and completely encircling the core.
3. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein said membrane has a radially outwardly extending flange at the second end thereof adjacent to the passageway of the inner core, and the cover also has a radially outwardly extending flange pressing the flange on the membrane into fluid tight contact with a radially outwardly extending flange at the passageway opening into the inner core.
4. A continuously sealing one way valve assembly and delivery system as set forth in claim 3 , wherein a collar and connector member on the source secure the valve assembly to the source.
5. A continuously sealing one way valve assembly and delivery system as set forth in claim 4 wherein the connector member is a threaded screw which mates to the collar.
6. A continuously sealing one way valve assembly and delivery system as set forth in claim 4 wherein a collar and connector member on the source secure the valve assembly to the source and effect a positive lock preventing opening of the source.
7. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein the outlet orifice in the cover is arranged so that it can dispense a selected quantity of the flowable substance.
8. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein the outlet orifice in the cover is formed of a soft material.
9. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein the outlet orifice in the cover is formed of a flexible material.
10. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein the cover is formed of an inner axially extending flexible member laterally enclosed by an axially extending rigid plastic shell.
11. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein an overcap is arranged to fit over and form a seal with said valve assembly sufficient to prevent external contamination from coming in contact with the valve assembly during storage.
12. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein at least two ports extend from the passageway through the inner core and to the inner surface of the flexible membrane.
13. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein the source comprises a collapsible reservoir reducible in volume in proportion as the flowable substance is dispensed from of the collapsible reservoir.
14. A continuously sealing one way valve assembly and delivery system as set forth in claim 13 , wherein said collapsible reservoir is one of a bellows, a tube and an internal bag.
15. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein an axially extending housing laterally encloses the source.
16. A continuously sealing one way valve assembly and delivery system as set forth in claim 15 , wherein the housing has a slot extending in the axial direction for applying dispensing pressure to an actuator of the collapsible reservoir.
17. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein the cover has a closed outlet orifice which opens for dispensing the flowable substance from the cover when dispensing pressure is applied to the source.
18. A continuously sealing one way valve assembly and delivery system, as set forth in claim 17 , wherein the outlet orifice in the cover is impervious to the flowable substance and does not retain the flowable substance inwardly of the outlet orifice.
19. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 wherein the inner core is connected to a pump assembly and to an actuator such that flowable substance is dispensed from the outlet orifice when the actuator is depressed.
20. A one-way valve assembly and delivery system of claim 1 , wherein the source is filled with a preservative free product.
21. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product is selected from one of opthalmological products, otorhinolarygological products, dermatological products, gynecological products, and products for the treatment or prevention of anorectal disorders, dermatological disorders, pulmonary disorders or any product which can be administered to the body through mucus membranes.
22. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of methycellulose, hyaluronic acid, polyethelene glycol 400 0.4%, propylene glycol 0.3%, glycerin, and mineral oils.
23. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of timolol 0.25%/0.50%, brimonidine tartrate 0.1%, bimatoprost 0.03% and travaprost 0.004%.
24. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of olopatadine HCL 0.1% and prednisolone acetate 1%.
25. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of ketorolac 0.5% and diclofenac 0.1%.
26. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of phenylephrine 0.25% and pseudoephedrine 30 mg.
27. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of skin preparations; scalp preparations; corticosteroid creams, lotions and ointments; topical antibiotics and topical anti-fungal agents.
28. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of skin preparations; scalp preparations; corticosteroid creams, lotions and ointments; topical antibiotics; topical anti-fungal agents; therapeutic skin creams including anti-bacterial, anti-fungal/parasitic, allergic and non-specific dermatitis creams and emollients and cosmetic dermatologic compounds used for dermatologic disorders
29. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of creams, topical anaesthetics, lubricating jellies and other preparations for hemorrhoid treatment, prevention or management.
30. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of B-adrenergic, anticholinergic, corticosteroid and theophyline derivatives.
31. A one-way valve assembly and delivery system of claim 20 wherein said preservative-free product comprises a product selected from one of azoles, nystatins, butoconazole, butoconalzole 2%, clotrimazole, clotrimazole 1%, metronidazole and trichomonas treatments.
32. A one-way valve assembly and delivery system of claim 19 , wherein said product is a contact lens care product.
33. A one-way valve assembly and delivery system of claim 19 , wherein said product is selected from one of: herbal, cosmetic, eye wash or skin care products.
34. A continuously sealing one way valve assembly and delivery system as set forth in claim 1 , wherein the continuously sealing one way valve assembly and delivery system can dispense multiple doses of preservative-free product.
35. A continuously sealing one way valve assembly and delivery system for dispensing a preservative-free flowable substance, comprising:
a source for storage of the preservative-free flowable substance, the source having an opening;
a valve assembly coupled to the opening of the source, said valve assembly including
(i) an inner core having an inlet opening for receiving the preservative-free flowable substance into a passageway and at least one port opening from the passageway,
(ii) a hollow flexible membrane having a first end and a second end, the first end being thicker than the second end, wherein the hollow flexible membrane is fitted over an outer surface of the inner core and when the preservative-free flowable substance is placed under pressure the preservative-free flowable substance exits through the at least one port opening and expands said membrane outwardly from said outer surface of said inner core;
a cover enclosing the flexible membrane and having an outlet orifice for dispensing the preservative-free flowable substance from the valve assembly when pressure is applied to the preservative-free flowable substance and
wherein when the pressure on the preservative-free flowable substance is released, the first end of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of the inner core before the remainder of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of said inner core.
36. A continuously sealing one way valve assembly and delivery system for dispensing multiple doses of a preservative-free flowable substance, comprising:
a source for storage of the preservative-free flowable substance, the source having an opening;
a valve assembly coupled to the opening of the source, said valve assembly including
(i) an inner core having an inlet opening for receiving the preservative-free flowable substance into a passageway and at least one port opening from the passageway,
(ii) a hollow flexible membrane having a first end and a second end, the first end being thicker than the second end, wherein the hollow flexible membrane is fitted over an outer surface of the inner core and when the preservative-free flowable substance is placed under pressure the preservative-free flowable substance exits through the at least one port opening and expands said membrane outwardly from said outer surface of said inner core;
a cover enclosing the flexible membrane and having an outlet orifice for dispensing the preservative-free flowable substance from the valve assembly when pressure is applied to the preservative-free flowable substance and
wherein when the pressure on the preservative-free flowable substance is released, the first end of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of the inner core before the remainder of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of said inner core.
37. A delivery system comprising:
a source for storage of a flowable substance, the source having an opening;
a valve assembly coupled to the opening of the source, said valve assembly including
(i) an inner core having an inlet opening for receiving the flowable substance into a passageway and at least one port opening from the passageway,
(ii) a hollow flexible membrane having a first end and a second end, the first end being thicker than the second end, wherein the hollow flexible membrane is fitted over an outer surface of the inner core and when the flowable substance is placed under pressure the flowable substance exits through the at least one port opening and expands said membrane outwardly from said outer surface of said inner core;
a cover enclosing the flexible membrane and having an outlet orifice for dispensing the flowable substance from the valve assembly when pressure is applied to the flowable substance and
wherein when the pressure on the flowable substance is released, the first end of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of the inner core before the remainder of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of said inner core.
38. A continuously sealing one way valve assembly and delivery system for dispensing a flowable substance, comprising:
a source for storage of the flowable substance, the source having an opening;
a valve assembly coupled to the opening of the source, said valve assembly including
(i) an inner core having an inlet opening for receiving the flowable substance into a passageway and at least one port opening from the passageway,
(ii) a hollow flexible membrane having a first end and a second end, the first end being thicker than the second end, wherein the hollow flexible membrane is fitted over an outer surface of the inner core and when the flowable substance is placed under pressure the flowable substance exits through the at least one port opening and expands said membrane outwardly from said outer surface of said inner core;
a cover enclosing the flexible membrane and having an outlet orifice for dispensing the flowable substance from the valve assembly when pressure is applied to the flowable substance and
wherein when the pressure on the flowable substance is released, the first end of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of the inner core before the remainder of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of said inner core, and
wherein at least one of said inner core, hollow flexible membrane and cover comprises an antimicrobial material.
39. A one-way valve assembly and delivery system of claim 38 , wherein said antimicrobial material is selected from one of silver ions contained within a ceramic carrier and sustained-release ionic silver compounds.
40. A continuously sealing one way valve assembly and delivery system for dispensing a flowable substance, comprising:
a source for storage of the flowable substance, the source having an opening;
a valve assembly coupled to the opening of the source, said valve assembly including
(i) an inner core having an inlet opening for receiving the flowable substance into a passageway and at least one port opening from the passageway,
(ii) a hollow flexible membrane having a first end and a second end, the first end being thicker than the second end, wherein the hollow flexible membrane is fitted over an outer surface of the inner core and when the flowable substance is placed under pressure the flowable substance exits through the at least one port opening and expands said membrane outwardly from said outer surface of said inner core;
a cover enclosing the flexible membrane and having an outlet orifice for dispensing the flowable substance from the valve assembly when pressure is applied to the flowable substance and
wherein when the pressure on the flowable substance is released, the first end of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of the inner core before the remainder of the hollow flexible membrane moves back into tightly fitting contact with the outer surface of said inner core, and
wherein at least one of said hollow flexible membrane and cover comprises a hydrophobic material.
41. A one-way valve assembly and delivery system of claim 40 , wherein said hydrophobic material is selected from one of positively charged material, low friction material, high surface tension material, or anti-wetting material.
42. A one-way valve assembly and delivery system of claim 41 , wherein said wherein said low friction material is Teflon.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/092,689 US20090218373A1 (en) | 2005-03-11 | 2006-11-03 | Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein |
US12/274,137 US7874467B2 (en) | 2005-11-03 | 2008-11-19 | Metered drop push button dispenser system |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11267868 | 2005-03-11 | ||
US11/267,868 US7306129B2 (en) | 2005-11-03 | 2005-11-03 | One way valve assembly |
US82346206P | 2006-08-24 | 2006-08-24 | |
PCT/US2006/042940 WO2007056131A2 (en) | 2005-11-03 | 2006-11-03 | Continuously sealing one way valve assembly and fluid delivery system formulations for use therein |
US12/092,689 US20090218373A1 (en) | 2005-03-11 | 2006-11-03 | Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/267,868 Continuation-In-Part US7306129B2 (en) | 2005-03-11 | 2005-11-03 | One way valve assembly |
PCT/US2006/042940 A-371-Of-International WO2007056131A2 (en) | 2005-03-11 | 2006-11-03 | Continuously sealing one way valve assembly and fluid delivery system formulations for use therein |
US12/274,137 Continuation-In-Part US7874467B2 (en) | 2005-11-03 | 2008-11-19 | Metered drop push button dispenser system |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/274,137 Continuation-In-Part US7874467B2 (en) | 2005-11-03 | 2008-11-19 | Metered drop push button dispenser system |
Publications (1)
Publication Number | Publication Date |
---|---|
US20090218373A1 true US20090218373A1 (en) | 2009-09-03 |
Family
ID=38023825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/092,689 Abandoned US20090218373A1 (en) | 2005-03-11 | 2006-11-03 | Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein |
Country Status (12)
Country | Link |
---|---|
US (1) | US20090218373A1 (en) |
EP (1) | EP1948522A4 (en) |
JP (1) | JP5132571B2 (en) |
KR (1) | KR20080093971A (en) |
AU (1) | AU2006311890A1 (en) |
BR (1) | BRPI0619710A2 (en) |
CA (1) | CA2628437A1 (en) |
MX (1) | MX2008005788A (en) |
NZ (1) | NZ568647A (en) |
RU (1) | RU2407682C2 (en) |
TW (1) | TW200735906A (en) |
WO (1) | WO2007056131A2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110068133A1 (en) * | 2008-03-27 | 2011-03-24 | Gaetan Painchaud | Device for dispensing a liquid in a tank |
US20110284579A1 (en) * | 2010-04-06 | 2011-11-24 | Reseal International Limited Partnership | Delivery system for dispensing metered volumes of pure or sterile flowable substances |
US20140336596A1 (en) * | 2011-11-21 | 2014-11-13 | Matthias Wochele | Dispenser for dispensing pharmaceutical liquids |
USD737951S1 (en) | 2013-11-26 | 2015-09-01 | Church & Dwight Co., Inc. | Nozzle |
US20180154092A1 (en) * | 2015-06-12 | 2018-06-07 | Philip Morris Products S.A. | Dispensing mechanism |
CN112423826A (en) * | 2018-06-11 | 2021-02-26 | 宝洁公司 | Methods and administration devices for treating vaginal conditions |
USD942586S1 (en) | 2018-11-27 | 2022-02-01 | Church & Dwight Co., Inc. | Front band on a spray nozzle |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7306129B2 (en) | 2005-11-03 | 2007-12-11 | Stewart Swiss | One way valve assembly |
US7874467B2 (en) * | 2005-11-03 | 2011-01-25 | Reseal International Limited Partnership | Metered drop push button dispenser system |
EP2190753A4 (en) * | 2007-09-07 | 2011-07-13 | Reseal Internat Partnership Ltd | Metered drop push button dispenser system |
FR2934572A1 (en) * | 2008-07-31 | 2010-02-05 | Thea Lab | BOTTLE FOR FLASK OF LIQUID CONDITIONING TO DISPENSE DROP GOUTTE. |
WO2010136585A2 (en) * | 2009-05-29 | 2010-12-02 | Galderma Research & Development | Combination of adrenergic receptor agonist -1 or -2, preferably brimonidine with fillers, preferablyhyaluronic acid |
JP5801163B2 (en) * | 2011-10-28 | 2015-10-28 | 株式会社吉野工業所 | Discharge container |
JP5878000B2 (en) * | 2011-10-28 | 2016-03-08 | 株式会社吉野工業所 | Discharge container |
GR1008330B (en) * | 2013-10-17 | 2014-10-20 | "Φαρματεν Α.Β.Ε.Ε.", | Preservative free pharmaceutical compositions for ophthalmic administration having improved physical characteristics and drop volume |
AU2014347153B2 (en) * | 2013-11-05 | 2019-08-29 | Alcon Inc. | Ophthalmic lubrication system and associated apparatus |
KR101554189B1 (en) | 2013-12-10 | 2015-09-21 | (주)연우 | Tube type cosmetic vessel exhausting into the form of water drop |
TWI580449B (en) * | 2015-04-29 | 2017-05-01 | 周正堉 | Medical connector and one-way valve module |
WO2021021003A1 (en) * | 2019-08-01 | 2021-02-04 | Герман Вячеславович КИЧАТОВ | Pulse trigger |
WO2021091402A1 (en) * | 2019-11-05 | 2021-05-14 | Gamboa Burgos Alejandro | Kit for ophthalmic solutions in screw-cap drop bottles |
Citations (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2715980A (en) * | 1950-10-09 | 1955-08-23 | Leo M Harvey | Liquid handling dispenser |
US3124275A (en) * | 1964-03-10 | Liquid dispensing container | ||
US3506163A (en) * | 1968-05-22 | 1970-04-14 | James A Rauh | Article for holding and dispensing flowable materials |
US3739652A (en) * | 1972-03-23 | 1973-06-19 | Caterpillar Tractor Co | Swing transmission for excavators |
US4349133A (en) * | 1979-09-12 | 1982-09-14 | Christine William C | Dispenser and refill package |
US4387734A (en) * | 1981-07-16 | 1983-06-14 | American Hospital Supply Corporation | Apparatus and method for spontaneous meniscus generation |
US4397132A (en) * | 1981-05-01 | 1983-08-09 | The Reseal Container Corporation Of America | Method for manufacturing a container assembly for storing and dispensing fluid materials |
US4413757A (en) * | 1981-03-09 | 1983-11-08 | Adler Harold A | Dispenser for repelling animals |
US4415121A (en) * | 1981-06-12 | 1983-11-15 | The Reseal Corporation Of America | Valve for spraying a mist |
US4421510A (en) * | 1979-01-18 | 1983-12-20 | Ahlbeck Stig Goran | Urine drainage device permitting training of the bladder |
US4846810A (en) * | 1987-07-13 | 1989-07-11 | Reseal International Limited Partnership | Valve assembly |
US4898306A (en) * | 1988-01-13 | 1990-02-06 | Reseal International Limited Partnership | Collapsible container for flowable substances |
US5080138A (en) * | 1990-10-31 | 1992-01-14 | Reseal International Limited Partnership | Valve assembly with multi-part valve body |
US5092855A (en) * | 1990-01-22 | 1992-03-03 | Reseal International Limited Partnership | Enclosing sleeve for one-way valve |
US5190190A (en) * | 1990-02-24 | 1993-03-02 | Weener-Plastik Gmbh & Co. Kg | Moldable two-part valve body |
US5305786A (en) * | 1993-01-14 | 1994-04-26 | Reseal International Limited Partnership | One-way valve assembly |
US5836484A (en) * | 1996-10-03 | 1998-11-17 | Gerber; Bernard R. | Contamination-safe multiple-dose dispensing cartridge for flowable materials |
US6325253B1 (en) * | 2001-02-02 | 2001-12-04 | Owens-Illinois Closure Inc. | Self-closing fluid dispensing closure |
US6386395B1 (en) * | 1998-02-10 | 2002-05-14 | Mrp Medical Research And Promotion Establishment | Multiple-dose bottle with dosage spout for products, particularly medicines |
US6536631B1 (en) * | 1998-04-29 | 2003-03-25 | Jean-Charles Nickels | Sealed fluid dispensing device |
US6662977B2 (en) * | 2002-03-14 | 2003-12-16 | Bernard R. Gerber | Modular valve assembly and system with airtight, leakproof and shockproof closure for engagement in the neck of a container |
US6695173B1 (en) * | 1999-06-24 | 2004-02-24 | Mrp Medical Research & Promotion Establishment | Multiple-dose bottle with dosage nozzle for liquids, particularly for pharmaceutical products |
US6766816B2 (en) * | 2001-10-03 | 2004-07-27 | Hunter Group, Inc. | Collapsible dispensing system |
US6896151B1 (en) * | 2002-11-04 | 2005-05-24 | Owens-Illinois Closure Inc. | Self-closing fluid dispensing closure |
US6997219B2 (en) * | 2003-05-12 | 2006-02-14 | Medical Instill Technologies, Inc. | Dispenser and apparatus and method for filling a dispenser |
US7077176B2 (en) * | 2003-04-28 | 2006-07-18 | Medical Instill Technologies, Inc. | Container with valve assembly for filling and dispensing substances, and apparatus and method for filling |
US7152759B2 (en) * | 2001-12-17 | 2006-12-26 | Ebac Limited | Bottled liquid dispensers |
US7226237B2 (en) * | 2002-09-23 | 2007-06-05 | Gildo Ceccarelli | Road barrier |
US7306129B2 (en) * | 2005-11-03 | 2007-12-11 | Stewart Swiss | One way valve assembly |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB773955A (en) * | 1955-11-16 | 1957-05-01 | Marcus Leonard Silver | Icing syringe |
US4099651A (en) * | 1975-05-22 | 1978-07-11 | Von Winckelmann Emil H | Closure assembly for collapsible tube dispensers, and the like |
AU594927B2 (en) * | 1984-08-16 | 1990-03-22 | Boots Company (Australia) Proprietary Limited, The | Packaging |
JPH0422861Y2 (en) * | 1986-08-11 | 1992-05-26 | ||
USRE34243E (en) | 1987-07-13 | 1993-05-04 | Reseal International Limited Partnership | Valve assembly |
EP0302575A1 (en) * | 1987-08-05 | 1989-02-08 | Gist-Brocades N.V. | Head for a container intended for repeated use |
DE3829356A1 (en) * | 1988-08-30 | 1990-03-01 | Sanner Friedr Gmbh Co Kg | Self-closing container closure |
US5305783A (en) * | 1991-12-31 | 1994-04-26 | Reseal International Limited Partnership | Elastomeric sleeve and method for assembling the sleeve on a one-way valve body |
US5353961A (en) * | 1993-01-15 | 1994-10-11 | Reseal International Limited Partnership | Dual chamber dispenser |
DE10303605A1 (en) * | 2003-01-30 | 2004-08-19 | Gaplast Gmbh | One-way valve device |
-
2006
- 2006-11-02 TW TW095140558A patent/TW200735906A/en unknown
- 2006-11-03 MX MX2008005788A patent/MX2008005788A/en active IP Right Grant
- 2006-11-03 JP JP2008539054A patent/JP5132571B2/en not_active Expired - Fee Related
- 2006-11-03 CA CA 2628437 patent/CA2628437A1/en not_active Abandoned
- 2006-11-03 NZ NZ568647A patent/NZ568647A/en not_active IP Right Cessation
- 2006-11-03 WO PCT/US2006/042940 patent/WO2007056131A2/en active Application Filing
- 2006-11-03 RU RU2008122052A patent/RU2407682C2/en not_active IP Right Cessation
- 2006-11-03 EP EP06827438A patent/EP1948522A4/en not_active Withdrawn
- 2006-11-03 AU AU2006311890A patent/AU2006311890A1/en not_active Abandoned
- 2006-11-03 US US12/092,689 patent/US20090218373A1/en not_active Abandoned
- 2006-11-03 KR KR20087013426A patent/KR20080093971A/en not_active Application Discontinuation
- 2006-11-03 BR BRPI0619710-8A patent/BRPI0619710A2/en not_active IP Right Cessation
Patent Citations (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3124275A (en) * | 1964-03-10 | Liquid dispensing container | ||
US2715980A (en) * | 1950-10-09 | 1955-08-23 | Leo M Harvey | Liquid handling dispenser |
US3506163A (en) * | 1968-05-22 | 1970-04-14 | James A Rauh | Article for holding and dispensing flowable materials |
US3739652A (en) * | 1972-03-23 | 1973-06-19 | Caterpillar Tractor Co | Swing transmission for excavators |
US4421510A (en) * | 1979-01-18 | 1983-12-20 | Ahlbeck Stig Goran | Urine drainage device permitting training of the bladder |
US4349133A (en) * | 1979-09-12 | 1982-09-14 | Christine William C | Dispenser and refill package |
US4413757A (en) * | 1981-03-09 | 1983-11-08 | Adler Harold A | Dispenser for repelling animals |
US4397132A (en) * | 1981-05-01 | 1983-08-09 | The Reseal Container Corporation Of America | Method for manufacturing a container assembly for storing and dispensing fluid materials |
US4415121A (en) * | 1981-06-12 | 1983-11-15 | The Reseal Corporation Of America | Valve for spraying a mist |
US4387734A (en) * | 1981-07-16 | 1983-06-14 | American Hospital Supply Corporation | Apparatus and method for spontaneous meniscus generation |
US4846810A (en) * | 1987-07-13 | 1989-07-11 | Reseal International Limited Partnership | Valve assembly |
US4898306A (en) * | 1988-01-13 | 1990-02-06 | Reseal International Limited Partnership | Collapsible container for flowable substances |
US5092855A (en) * | 1990-01-22 | 1992-03-03 | Reseal International Limited Partnership | Enclosing sleeve for one-way valve |
US5190190A (en) * | 1990-02-24 | 1993-03-02 | Weener-Plastik Gmbh & Co. Kg | Moldable two-part valve body |
US5080138A (en) * | 1990-10-31 | 1992-01-14 | Reseal International Limited Partnership | Valve assembly with multi-part valve body |
US5305786A (en) * | 1993-01-14 | 1994-04-26 | Reseal International Limited Partnership | One-way valve assembly |
US5836484A (en) * | 1996-10-03 | 1998-11-17 | Gerber; Bernard R. | Contamination-safe multiple-dose dispensing cartridge for flowable materials |
US6386395B1 (en) * | 1998-02-10 | 2002-05-14 | Mrp Medical Research And Promotion Establishment | Multiple-dose bottle with dosage spout for products, particularly medicines |
US6536631B1 (en) * | 1998-04-29 | 2003-03-25 | Jean-Charles Nickels | Sealed fluid dispensing device |
US6695173B1 (en) * | 1999-06-24 | 2004-02-24 | Mrp Medical Research & Promotion Establishment | Multiple-dose bottle with dosage nozzle for liquids, particularly for pharmaceutical products |
US6325253B1 (en) * | 2001-02-02 | 2001-12-04 | Owens-Illinois Closure Inc. | Self-closing fluid dispensing closure |
US6766816B2 (en) * | 2001-10-03 | 2004-07-27 | Hunter Group, Inc. | Collapsible dispensing system |
US7152759B2 (en) * | 2001-12-17 | 2006-12-26 | Ebac Limited | Bottled liquid dispensers |
US6662977B2 (en) * | 2002-03-14 | 2003-12-16 | Bernard R. Gerber | Modular valve assembly and system with airtight, leakproof and shockproof closure for engagement in the neck of a container |
US7226237B2 (en) * | 2002-09-23 | 2007-06-05 | Gildo Ceccarelli | Road barrier |
US6896151B1 (en) * | 2002-11-04 | 2005-05-24 | Owens-Illinois Closure Inc. | Self-closing fluid dispensing closure |
US7077176B2 (en) * | 2003-04-28 | 2006-07-18 | Medical Instill Technologies, Inc. | Container with valve assembly for filling and dispensing substances, and apparatus and method for filling |
US6997219B2 (en) * | 2003-05-12 | 2006-02-14 | Medical Instill Technologies, Inc. | Dispenser and apparatus and method for filling a dispenser |
US7306129B2 (en) * | 2005-11-03 | 2007-12-11 | Stewart Swiss | One way valve assembly |
US7513396B2 (en) * | 2005-11-03 | 2009-04-07 | Reseal International Limited Partnership | One way valve assembly |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110068133A1 (en) * | 2008-03-27 | 2011-03-24 | Gaetan Painchaud | Device for dispensing a liquid in a tank |
US8517222B2 (en) * | 2008-03-27 | 2013-08-27 | Rexam Healthcare La Verpilliere | Device for dispensing a liquid in a tank |
US20110284579A1 (en) * | 2010-04-06 | 2011-11-24 | Reseal International Limited Partnership | Delivery system for dispensing metered volumes of pure or sterile flowable substances |
US9241828B2 (en) * | 2010-04-06 | 2016-01-26 | Reseal International Limited Partnership | Delivery system for dispensing metered volumes of pure or sterile flowable substances |
US20140336596A1 (en) * | 2011-11-21 | 2014-11-13 | Matthias Wochele | Dispenser for dispensing pharmaceutical liquids |
US9833356B2 (en) * | 2011-11-21 | 2017-12-05 | Aptar Radolfzell Gmbh | Dispenser for dispensing pharmaceutical liquids |
USD737951S1 (en) | 2013-11-26 | 2015-09-01 | Church & Dwight Co., Inc. | Nozzle |
US20180154092A1 (en) * | 2015-06-12 | 2018-06-07 | Philip Morris Products S.A. | Dispensing mechanism |
CN112423826A (en) * | 2018-06-11 | 2021-02-26 | 宝洁公司 | Methods and administration devices for treating vaginal conditions |
USD942586S1 (en) | 2018-11-27 | 2022-02-01 | Church & Dwight Co., Inc. | Front band on a spray nozzle |
Also Published As
Publication number | Publication date |
---|---|
KR20080093971A (en) | 2008-10-22 |
EP1948522A2 (en) | 2008-07-30 |
EP1948522A4 (en) | 2011-10-19 |
MX2008005788A (en) | 2008-09-09 |
JP5132571B2 (en) | 2013-01-30 |
RU2407682C2 (en) | 2010-12-27 |
NZ568647A (en) | 2011-06-30 |
JP2009514601A (en) | 2009-04-09 |
WO2007056131A2 (en) | 2007-05-18 |
WO2007056131B1 (en) | 2007-09-27 |
AU2006311890A1 (en) | 2007-05-18 |
CA2628437A1 (en) | 2007-05-18 |
RU2008122052A (en) | 2009-12-20 |
TW200735906A (en) | 2007-10-01 |
WO2007056131A3 (en) | 2007-08-16 |
BRPI0619710A2 (en) | 2011-10-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7874467B2 (en) | Metered drop push button dispenser system | |
US20090218373A1 (en) | Continuously sealing one way valve assembly and fluid delivery system and formulations for use therein | |
EP1948523B1 (en) | One way valve assembly | |
CN101351387A (en) | Continuously sealing one way valve assembly and fluid delivery system formulations for use therein | |
WO2009033053A1 (en) | Metered drop push button dispenser system | |
JP2013523317A (en) | Delivery system for volumetric dispensing of pure or sterile flowable material | |
RU2410302C2 (en) | One-stroke valve block |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: RESEAL INTERNATIONAL LIMITED PARTNERSHIP, NEW YORK Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PARDES, GREG;REEL/FRAME:023043/0692 Effective date: 20090801 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO PAY ISSUE FEE |