US20090226502A1 - Balloon catheter devices with solvent-swellable polymer - Google Patents
Balloon catheter devices with solvent-swellable polymer Download PDFInfo
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- US20090226502A1 US20090226502A1 US12/399,532 US39953209A US2009226502A1 US 20090226502 A1 US20090226502 A1 US 20090226502A1 US 39953209 A US39953209 A US 39953209A US 2009226502 A1 US2009226502 A1 US 2009226502A1
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- polymer
- balloon
- solvent
- styrene
- block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
- A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2009/00—Layered products
- B29L2009/005—Layered products coated
Definitions
- the present invention relates to medical devices, more particularly, to catheter devices.
- Balloon catheters having drug coatings may be used to treat diseased portions of blood vessels.
- the balloon is inserted through a peripheral blood vessel and then guided via a catheter through the vascular system to the target intravascular site.
- the flow of blood may wash away some of the drug coating.
- the control of the timing, location and/or duration of the release of the drug can be an issue. Therefore, there is a need for improved catheter-based devices for drug delivery to an intravascular site.
- the present invention provides a method for making a medical device, comprising: providing a balloon, wherein a wall of the balloon or a coating over the balloon comprises a polymer, wherein the polymer is swellable in an organic solvent; exposing said polymer to a mixture of said solvent and a therapeutic agent; and removing the solvent.
- FIGS. 1A and 1B show a catheter device according to an embodiment of the present invention.
- FIG. 1A shows the catheter device with the balloon in a deflated state.
- FIG. 1B shows the catheter device with the balloon in an inflated state.
- FIGS. 2A-2C schematically illustrate a polymer matrix in a balloon wall or a balloon coating according to an embodiment of the present invention.
- FIG. 2A shows the polymer matrix prior to solvent exposure.
- FIG. 2B shows the polymer matrix in an expanded condition after exposure to a mixture of a solvent and a therapeutic agent.
- FIG. 2C shows the polymer matrix in a contracted condition after the removal of the solvent.
- Catheter devices of the present invention use an expandable balloon for delivering a therapeutic agent to a target site in the body.
- the balloon is designed to be insertable in the body via a catheter.
- the therapeutic agent can be associated with the balloon in any of various ways, as further described below. Any of various mechanisms conventionally used for the delivery, actuation, or expansion (e.g., by inflation) of balloon catheter devices may be used in the present invention.
- the balloon catheter may be designed similar to those that have been known in the art, including but not limited to angioplasty catheters, stent delivery catheters, inflation catheters and/or perfusion catheters.
- the catheter devices of the present invention may be used in conjunction with other drug delivery devices, such as stents.
- a balloon catheter 20 comprises a catheter body 22 having a balloon 24 mounted thereon.
- the balloon In FIG. 1A , the balloon is in a deflated state; in FIG. 1B , the balloon is in an inflated state.
- the body of the balloon can be single-layered or multiple-layered.
- a balloon comprises a solvent-swellable polymer.
- the solvent-swellable polymer may have a therapeutic agent incorporated therein and may be used to form a wall of the balloon or to form a coating disposed over the balloon.
- the polymer is swellable upon exposure to an organic solvent.
- the organic solvent can be polar or non-polar.
- the organic solvent has a low boiling point.
- the organic solvent has a boiling point of about 90° C. or less, about 80° C. or less, or about 70° C. or less. Solvents with low boiling points can be removed relatively easier than those with high boiling points.
- Non-limiting examples of organic solvents include dichloromethane, chloroform, carbon tetrachloride, ethyl acetate, tetrahydrofuran, acetonitrile, hexane, and cyclohexane.
- the solvent-swellable polymer is a semi-crystalline polymer.
- the semi-crystalline polymer can form a polymer matrix having crystalline portions and amorphous portions.
- the solvent and the therapeutic agent diffuses into and swells preferentially the amorphous regions of the polymer matrix.
- the crystalline portions of the polymer matrix are more resistant to swelling, and therefore form a stable structure that maintains the physical structure of the polymer-containing balloon wall or coating.
- the solvent is removed, the polymer matrix contracts to its original conformation, entrapping the therapeutic agent within the polymer matrix.
- a catheter device comprises a balloon comprising a solvent-swellable, semi-crystalline polymer.
- FIG. 2A shows a polymer matrix 70 on the wall of the balloon prior to solvent exposure.
- Polymer matrix 70 has crystalline regions 72 , which are represented schematically by the lines, and amorphous regions 74 , which are represented schematically by the spaces.
- FIG. 2B upon exposure to a mixture of a solvent and a therapeutic agent, amorphous regions 74 absorb the solvent and therapeutic agent 76 , causing polymer matrix 70 to swell.
- FIG. 2C upon removal of the solvent, polymer matrix 70 contracts to its original conformation such that therapeutic agent 76 is retained within polymer matrix 70 .
- the solvent-swellable polymer is a partially cross-linked polymer.
- the cross-linking density is low to allow at least a portion of the polymer to swell in an organic solvent.
- the cross-linking can be done using any known methods.
- the cross-linking may be induced by UV irradiation or electron beam irradiation.
- the cross-linked portions of the polymer serve as the stable structure, while the non-crosslinked portions of the polymer swell upon exposure to an organic solvent and entrap the therapeutic agent previously mixed with the solvent after the solvent is removed.
- the solvent-swellable polymer is grafted onto the surface of the balloon through chemical bonding.
- the balloon wall base itself serves as the stable structure, while the polymer swells upon exposure to an organic solvent and entraps the therapeutic agent previously mixed with the solvent after the solvent is removed.
- Non-limiting examples of solvent-swellable polymers include block copolymers of styrene-ethylene/butylene-styrene (“SEBS”), block copolymers of styrene-ethylene/propylene-styrene (“SEPS”), block copolymers of styrene-butadiene-styrene (“SBS”), block copolymers of styrene-isoprene-styrene (“SIS”), polyolefins such as polyethylene and polypropylene, polyurethane, polyoxymethylene-acetyl copolymers, polyamide block copolymers, and copolymers of acrylates and methacrylates.
- SEBS block copolymers of styrene-ethylene/butylene-styrene
- SEPS styrene-ethylene/propylene-styrene
- SBS block copolymers of styrene-buta
- the SEBS, SEPS, SBS, and SIS copolymers can be commercially-available copolymers, such as those sold under the trade names KRATON G and KRATON D.
- the solvent-swellable polymer has unsaturated bonds to allow for cross-linking or grafting.
- the solvent may be removed by any known method, for example, evaporation or vacuum drying.
- the solvent is removed without heating.
- the solvent is removed by evaporation.
- the balloon comprising a therapeutic agent-containing polymer is inserted into the body and delivered to the target site.
- the balloon is then inflated, causing the polymer (in the case of a semi-crystalline polymer being used, polymer matrix 70 ) in the balloon wall to undergo expansion by mechanical force.
- the therapeutic agent e.g. therapeutic agent 76
- the therapeutic agent is released from the wall of the balloon. Because the therapeutic agent is preferably loaded through diffusion, it tends to locate near the surface of the wall or coating and can be easily released after the balloon catheter device is delivered to the target site.
- Medical devices of the present invention may also include a vascular stent mounted on the balloon.
- the vascular stent may be any of those known in the art, including those with or without coatings that contain a therapeutic agent.
- the stent may also be biostable, bioerodable, or biodegradable.
- the balloons of the present invention may also be coated with a low-molecular weight carbohydrate, such as mannitol.
- the carbohydrate may be a separate coating or be blended with the therapeutic agent.
- the balloons of the present invention may also be coated with a radiocontrast agent (ionic or non-ionic), such as iopromide.
- the contrast agent may be a separate coating or be blended with the therapeutic agent.
- the therapeutic agent used in the present invention may be any pharmaceutically acceptable agent (such as a drug), a biomolecule, a small molecule, or cells.
- Example drugs include anti-proliferative agents or anti-restenosis agents such as paclitaxel, sirolimus (rapamycin), tacrolimus, everolimus, and zotarolimus.
- Other example drugs include those that are anti-spasmodic agents and vasodilators.
- Example biomolecules include peptides, polypeptides and proteins; antibodies; oligonucleotides; nucleic acids such as double or single stranded DNA (including naked and cDNA), RNA, antisense nucleic acids such as antisense DNA and RNA, small interfering RNA (siRNA), and ribozymes; genes; carbohydrates; angiogenic factors including growth factors; cell cycle inhibitors; and anti-restenosis agents.
- Example small molecules include hormones, nucleotides, amino acids, sugars, and lipids and compounds have a molecular weight of less than 100 kD.
- Example cells include stem cells, progenitor cells, endothelial cells, adult cardiomyocytes, and smooth muscle cells.
- a double-layered balloon is manufactured.
- the inner layer is made of high density polyethylene and the outer layer is made of SEBS (KRATON G, Kraton Polymers, Houston, Tex.).
- SEBS KRATON G, Kraton Polymers, Houston, Tex.
- the SEBS in the outer layer is crosslinked by electron beam irradiation.
- the balloon is then immersed in a mixture of cyclohexane and paclitaxel for drug loading. After the balloon is taken out, the cyclohexane is removed by evaporation.
- the balloon is then assembled onto a balloon catheter device.
Abstract
Methods for making a balloon catheter device comprising a solvent-swellable polymer are provided. The method includes providing a balloon, wherein a wall of the balloon or a coating over the balloon comprises a polymer, wherein the polymer is swellable in an organic solvent. In certain embodiments of the invention, the polymer on the balloon is exposed to a mixture of said solvent and a therapeutic agent; and the solvent is thereafter removing, leaving the therapeutic agent in the polymer.
Description
- This application claims the benefit of provisional application Ser. No. 61/034,328, filed Mar. 6, 2008, which is incorporated herein by reference in its entirety.
- The present invention relates to medical devices, more particularly, to catheter devices.
- Catheters are used in a wide variety of minimally-invasive or percutaneous medical procedures. Balloon catheters having drug coatings may be used to treat diseased portions of blood vessels. Typically, the balloon is inserted through a peripheral blood vessel and then guided via a catheter through the vascular system to the target intravascular site. However, as the balloon travels through the vascular system, the flow of blood may wash away some of the drug coating. In addition, the control of the timing, location and/or duration of the release of the drug can be an issue. Therefore, there is a need for improved catheter-based devices for drug delivery to an intravascular site.
- In one embodiment, the present invention provides a method for making a medical device, comprising: providing a balloon, wherein a wall of the balloon or a coating over the balloon comprises a polymer, wherein the polymer is swellable in an organic solvent; exposing said polymer to a mixture of said solvent and a therapeutic agent; and removing the solvent.
-
FIGS. 1A and 1B show a catheter device according to an embodiment of the present invention.FIG. 1A shows the catheter device with the balloon in a deflated state.FIG. 1B shows the catheter device with the balloon in an inflated state. -
FIGS. 2A-2C schematically illustrate a polymer matrix in a balloon wall or a balloon coating according to an embodiment of the present invention.FIG. 2A shows the polymer matrix prior to solvent exposure.FIG. 2B shows the polymer matrix in an expanded condition after exposure to a mixture of a solvent and a therapeutic agent.FIG. 2C shows the polymer matrix in a contracted condition after the removal of the solvent. - Catheter devices of the present invention use an expandable balloon for delivering a therapeutic agent to a target site in the body. The balloon is designed to be insertable in the body via a catheter. The therapeutic agent can be associated with the balloon in any of various ways, as further described below. Any of various mechanisms conventionally used for the delivery, actuation, or expansion (e.g., by inflation) of balloon catheter devices may be used in the present invention. The balloon catheter may be designed similar to those that have been known in the art, including but not limited to angioplasty catheters, stent delivery catheters, inflation catheters and/or perfusion catheters. The catheter devices of the present invention may be used in conjunction with other drug delivery devices, such as stents.
- Referring to
FIGS. 1A and 1B , in certain embodiments, aballoon catheter 20 comprises acatheter body 22 having aballoon 24 mounted thereon. InFIG. 1A , the balloon is in a deflated state; inFIG. 1B , the balloon is in an inflated state. The body of the balloon can be single-layered or multiple-layered. - In one aspect of the present invention, a balloon comprises a solvent-swellable polymer. The solvent-swellable polymer may have a therapeutic agent incorporated therein and may be used to form a wall of the balloon or to form a coating disposed over the balloon.
- Preferably, the polymer is swellable upon exposure to an organic solvent. The organic solvent can be polar or non-polar. Preferably, the organic solvent has a low boiling point. Preferably, the organic solvent has a boiling point of about 90° C. or less, about 80° C. or less, or about 70° C. or less. Solvents with low boiling points can be removed relatively easier than those with high boiling points. Non-limiting examples of organic solvents include dichloromethane, chloroform, carbon tetrachloride, ethyl acetate, tetrahydrofuran, acetonitrile, hexane, and cyclohexane.
- Optionally, the solvent-swellable polymer is a semi-crystalline polymer. The semi-crystalline polymer can form a polymer matrix having crystalline portions and amorphous portions. When the polymer matrix is exposed to a mixture of a suitable organic solvent and a therapeutic agent, the solvent and the therapeutic agent diffuses into and swells preferentially the amorphous regions of the polymer matrix. The crystalline portions of the polymer matrix are more resistant to swelling, and therefore form a stable structure that maintains the physical structure of the polymer-containing balloon wall or coating. When the solvent is removed, the polymer matrix contracts to its original conformation, entrapping the therapeutic agent within the polymer matrix.
- For example, referring to the schematic illustration shown in
FIGS. 2A-2C , a catheter device comprises a balloon comprising a solvent-swellable, semi-crystalline polymer.FIG. 2A shows apolymer matrix 70 on the wall of the balloon prior to solvent exposure.Polymer matrix 70 hascrystalline regions 72, which are represented schematically by the lines, andamorphous regions 74, which are represented schematically by the spaces. Referring toFIG. 2B , upon exposure to a mixture of a solvent and a therapeutic agent,amorphous regions 74 absorb the solvent andtherapeutic agent 76, causingpolymer matrix 70 to swell. Referring toFIG. 2C , upon removal of the solvent,polymer matrix 70 contracts to its original conformation such thattherapeutic agent 76 is retained withinpolymer matrix 70. - Optionally, the solvent-swellable polymer is a partially cross-linked polymer. Preferably, the cross-linking density is low to allow at least a portion of the polymer to swell in an organic solvent. The cross-linking can be done using any known methods. For example, the cross-linking may be induced by UV irradiation or electron beam irradiation. The cross-linked portions of the polymer serve as the stable structure, while the non-crosslinked portions of the polymer swell upon exposure to an organic solvent and entrap the therapeutic agent previously mixed with the solvent after the solvent is removed.
- Optionally, the solvent-swellable polymer is grafted onto the surface of the balloon through chemical bonding. In this case, the balloon wall base itself serves as the stable structure, while the polymer swells upon exposure to an organic solvent and entraps the therapeutic agent previously mixed with the solvent after the solvent is removed.
- Non-limiting examples of solvent-swellable polymers include block copolymers of styrene-ethylene/butylene-styrene (“SEBS”), block copolymers of styrene-ethylene/propylene-styrene (“SEPS”), block copolymers of styrene-butadiene-styrene (“SBS”), block copolymers of styrene-isoprene-styrene (“SIS”), polyolefins such as polyethylene and polypropylene, polyurethane, polyoxymethylene-acetyl copolymers, polyamide block copolymers, and copolymers of acrylates and methacrylates. The SEBS, SEPS, SBS, and SIS copolymers can be commercially-available copolymers, such as those sold under the trade names KRATON G and KRATON D. Preferably, the solvent-swellable polymer has unsaturated bonds to allow for cross-linking or grafting.
- After the therapeutic agent is loaded into the polymer, the solvent may be removed by any known method, for example, evaporation or vacuum drying. Preferably, the solvent is removed without heating. Preferably, the solvent is removed by evaporation.
- In operation, the balloon comprising a therapeutic agent-containing polymer is inserted into the body and delivered to the target site. The balloon is then inflated, causing the polymer (in the case of a semi-crystalline polymer being used, polymer matrix 70) in the balloon wall to undergo expansion by mechanical force. By enlarging the space within the polymer (e.g. polymer matrix 70), the therapeutic agent (e.g. therapeutic agent 76) is released from the wall of the balloon. Because the therapeutic agent is preferably loaded through diffusion, it tends to locate near the surface of the wall or coating and can be easily released after the balloon catheter device is delivered to the target site.
- Medical devices of the present invention may also include a vascular stent mounted on the balloon. The vascular stent may be any of those known in the art, including those with or without coatings that contain a therapeutic agent. The stent may also be biostable, bioerodable, or biodegradable.
- The balloons of the present invention may also be coated with a low-molecular weight carbohydrate, such as mannitol. The carbohydrate may be a separate coating or be blended with the therapeutic agent. The balloons of the present invention may also be coated with a radiocontrast agent (ionic or non-ionic), such as iopromide. The contrast agent may be a separate coating or be blended with the therapeutic agent.
- The therapeutic agent used in the present invention may be any pharmaceutically acceptable agent (such as a drug), a biomolecule, a small molecule, or cells. Example drugs include anti-proliferative agents or anti-restenosis agents such as paclitaxel, sirolimus (rapamycin), tacrolimus, everolimus, and zotarolimus. Other example drugs include those that are anti-spasmodic agents and vasodilators. Example biomolecules include peptides, polypeptides and proteins; antibodies; oligonucleotides; nucleic acids such as double or single stranded DNA (including naked and cDNA), RNA, antisense nucleic acids such as antisense DNA and RNA, small interfering RNA (siRNA), and ribozymes; genes; carbohydrates; angiogenic factors including growth factors; cell cycle inhibitors; and anti-restenosis agents. Example small molecules include hormones, nucleotides, amino acids, sugars, and lipids and compounds have a molecular weight of less than 100 kD. Example cells include stem cells, progenitor cells, endothelial cells, adult cardiomyocytes, and smooth muscle cells.
- A double-layered balloon is manufactured. The inner layer is made of high density polyethylene and the outer layer is made of SEBS (KRATON G, Kraton Polymers, Houston, Tex.). The SEBS in the outer layer is crosslinked by electron beam irradiation. The balloon is then immersed in a mixture of cyclohexane and paclitaxel for drug loading. After the balloon is taken out, the cyclohexane is removed by evaporation. The balloon is then assembled onto a balloon catheter device.
- The foregoing description and examples have been set forth merely to illustrate the invention and are not intended to be limiting. Each of the disclosed aspects and embodiments of the present invention may be considered individually or in combination with other aspects, embodiments, and variations of the invention. Modifications of the disclosed embodiments incorporating the spirit and substance of the invention may occur to persons skilled in the art and such modifications are within the scope of the present invention.
Claims (20)
1. A method for making a medical device, comprising:
providing a balloon, wherein a wall of the balloon or a coating over the balloon comprises a polymer, wherein the polymer is swellable in an organic solvent;
exposing said polymer on the balloon to a mixture of said solvent and a therapeutic agent; and
removing the solvent.
2. The method of claim 1 , wherein a wall of the balloon comprises the polymer swellable in an organic solvent.
3. The method of claim 1 , wherein a coating over the balloon comprises the polymer swellable in an organic solvent.
4. The method of claim 3 , wherein the polymer is grafted to a wall of the balloon through chemical bonding.
5. The method of claim 1 , wherein the polymer is a semi-crystalline polymer comprising crystalline regions and amorphous regions.
6. The method of claim 1 , wherein the polymer is partially cross-linked.
7. The method of claim 1 , wherein the polymer is selected from the group consisting of block copolymers of styrene-ethylene/butylene-styrene, block copolymers of styrene-ethylene/propylene-styrene, block copolymers of styrene-butadiene, block copolymers of styrene-isoprene, polyolefins, polyurethane, polyoxymethylene-acetyl copolymers, polyamide block copolymers, copolymers of acrylates and methacrylates, and mixtures thereof.
8. The method of claim 7 , wherein the polymer is selected from the group consisting of block copolymers of styrene-ethylene/butylene-styrene, block copolymers of styrene-ethylene/propylene-styrene, block copolymers of styrene-butadiene, block copolymers of styrene-isoprene, polyurethane, and mixtures thereof.
9. The method of claim 1 , wherein the solvent is a polar organic solvent.
10. The method of claim 1 , wherein the solvent is a non-polar organic solvent.
11. The method of claim 1 , wherein the boiling point of the solvent is about 90° C. or less.
12. The method of claim 1 , wherein the solvent is selected from the group consisting of dichloromethane, chloroform, carbon tetrachloride, ethyl acetate, tetrahydrofuran, acetonitrile, hexane, cyclohexane, and mixtures thereof.
13. The method of claim 1 , wherein the solvent is removed by evaporation.
14. The method of claim 1 , wherein the therapeutic agent is selected from the group consisting of paclitaxel, sirolimus, tacrolimus, everolimus, zotarolimus, and mixtures thereof.
15. A method of releasing a therapeutic agent from the surface of a balloon catheter comprising:
providing a balloon, wherein a wall of the balloon or a coating over the balloon comprises a polymer, wherein the polymer is swellable in an organic solvent;
exposing said polymer on the balloon to a mixture of said solvent and a therapeutic agent;
removing the solvent; and
expanding the balloon to release the therapeutic agent.
16. The method of claim 15 , wherein the polymer is grafted to a wall of the balloon through chemical bonding.
17. The method of claim 15 , wherein the polymer is a semi-crystalline polymer comprising crystalline regions and amorphous regions.
18. The method of claim 15 , wherein the polymer is partially cross-linked.
19. The method of claim 15 , wherein the boiling point of the solvent is about 90° C. or less.
20. The method of claim 15 , wherein the solvent is removed by evaporation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US12/399,532 US20090226502A1 (en) | 2008-03-06 | 2009-03-06 | Balloon catheter devices with solvent-swellable polymer |
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Application Number | Priority Date | Filing Date | Title |
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US3432808P | 2008-03-06 | 2008-03-06 | |
US12/399,532 US20090226502A1 (en) | 2008-03-06 | 2009-03-06 | Balloon catheter devices with solvent-swellable polymer |
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US20090226502A1 true US20090226502A1 (en) | 2009-09-10 |
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Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/399,548 Expired - Fee Related US8114049B2 (en) | 2008-03-06 | 2009-03-06 | Balloon catheter devices with folded balloons |
US12/399,386 Abandoned US20090227948A1 (en) | 2008-03-06 | 2009-03-06 | Balloon catheter devices with sheath covering |
US12/399,532 Abandoned US20090226502A1 (en) | 2008-03-06 | 2009-03-06 | Balloon catheter devices with solvent-swellable polymer |
US13/179,054 Abandoned US20110270226A1 (en) | 2008-03-06 | 2011-07-08 | Balloon catheter devices with sheath covering |
US13/289,490 Abandoned US20120053517A1 (en) | 2008-03-06 | 2011-11-04 | Balloon catheter devices with sheath covering |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/399,548 Expired - Fee Related US8114049B2 (en) | 2008-03-06 | 2009-03-06 | Balloon catheter devices with folded balloons |
US12/399,386 Abandoned US20090227948A1 (en) | 2008-03-06 | 2009-03-06 | Balloon catheter devices with sheath covering |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/179,054 Abandoned US20110270226A1 (en) | 2008-03-06 | 2011-07-08 | Balloon catheter devices with sheath covering |
US13/289,490 Abandoned US20120053517A1 (en) | 2008-03-06 | 2011-11-04 | Balloon catheter devices with sheath covering |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100285085A1 (en) * | 2009-05-07 | 2010-11-11 | Abbott Cardiovascular Systems Inc. | Balloon coating with drug transfer control via coating thickness |
WO2012044913A1 (en) * | 2010-09-30 | 2012-04-05 | Suromdics, Inc. | Catheter assembly with guard |
US20120165922A1 (en) * | 2010-12-22 | 2012-06-28 | Gong Victoria M | Method of modifying a coating on a medical device |
WO2013015941A1 (en) | 2011-07-26 | 2013-01-31 | Medtronic Vascular Inc. | Textured dilatation balloon |
US8597720B2 (en) | 2007-01-21 | 2013-12-03 | Hemoteq Ag | Medical product for treating stenosis of body passages and for preventing threatening restenosis |
US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
US20140316515A1 (en) * | 2008-04-09 | 2014-10-23 | Alexander Rübben | Method for producing a bioactive surface on an endoprosthesis or on the balloon of a balloon catheter |
US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
US9415193B2 (en) | 2011-03-04 | 2016-08-16 | W. L. Gore & Associates, Inc. | Eluting medical devices |
US9901715B2 (en) | 2012-09-05 | 2018-02-27 | W. L. Gore Associates, Inc. | Retractable sheath devices, systems, and methods |
US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
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US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
US20200179659A1 (en) * | 2015-01-22 | 2020-06-11 | Intersect Ent, Inc. | Drug-coated balloon |
US11123528B2 (en) | 2016-07-04 | 2021-09-21 | Kaneka Corporation | Balloon catheter and method for manufacturing same |
US11672959B2 (en) | 2019-01-18 | 2023-06-13 | Intersect Ent, Inc. | Expandable member systems and methods for drug delivery |
US11690984B2 (en) | 2013-03-14 | 2023-07-04 | W. L. Gore & Associates, Inc. | Conformable balloon devices and methods |
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---|---|---|---|---|
US8177743B2 (en) | 1998-05-18 | 2012-05-15 | Boston Scientific Scimed, Inc. | Localized delivery of drug agents |
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US20090062909A1 (en) | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
CA2625264C (en) | 2005-10-13 | 2015-12-15 | Synthes (U.S.A.) | Drug-impregnated sleeve for a medical implant |
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US7777399B2 (en) * | 2006-07-31 | 2010-08-17 | Boston Scientific Scimed, Inc. | Medical balloon incorporating electroactive polymer and methods of making and using the same |
US9539593B2 (en) | 2006-10-23 | 2017-01-10 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US8153181B2 (en) | 2006-11-14 | 2012-04-10 | Boston Scientific Scimed, Inc. | Medical devices and related methods |
US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8425459B2 (en) * | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
US9737642B2 (en) | 2007-01-08 | 2017-08-22 | Micell Technologies, Inc. | Stents having biodegradable layers |
AU2008256684B2 (en) | 2007-05-25 | 2012-06-14 | Micell Technologies, Inc. | Polymer films for medical device coating |
WO2009061787A1 (en) * | 2007-11-05 | 2009-05-14 | Nanocopoeia, Inc. | Coated devices and method of making coated devices that reduce smooth muscle cell proliferation and platelet activity |
EP2262565A1 (en) * | 2008-03-06 | 2010-12-22 | Boston Scientific Scimed, Inc. | Balloon catheter devices with sheath covering |
US9480826B2 (en) | 2008-03-21 | 2016-11-01 | Cagent Vascular, Llc | Intravascular device |
US11219750B2 (en) | 2008-03-21 | 2022-01-11 | Cagent Vascular, Inc. | System and method for plaque serration |
CA2718067C (en) | 2008-03-21 | 2014-07-08 | Innovasc Llc | Device and method for opening blood vessels by pre-angioplasty serration and dilatation of atherosclerotic plaque |
CA2721832C (en) | 2008-04-17 | 2018-08-07 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
EP3159033B1 (en) | 2008-05-01 | 2019-02-27 | Bayer Intellectual Property GmbH | Catheter balloon drug adherence techniques and methods |
US9539381B2 (en) * | 2008-05-12 | 2017-01-10 | Humparkull, Llc | Hemostatic devices and methods for use thereof |
US10426483B2 (en) | 2008-05-12 | 2019-10-01 | Mitchell R. Humphreys | Hemostatic devices and methods for use thereof |
JP2011528275A (en) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | Drug delivery medical device |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
US8968239B2 (en) * | 2008-09-02 | 2015-03-03 | Jose E. Herrera | Catheter device for the dynamic regulation of the venous return to the heart for the treatment of patients with heart failure |
US8128951B2 (en) * | 2008-09-15 | 2012-03-06 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US9198968B2 (en) | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8257722B2 (en) * | 2008-09-15 | 2012-09-04 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8114429B2 (en) | 2008-09-15 | 2012-02-14 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
WO2010080575A2 (en) | 2008-12-18 | 2010-07-15 | Michal Konstantino | Method and apparatus for transport of substances into body tissue |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
CN102481195B (en) | 2009-04-01 | 2015-03-25 | 米歇尔技术公司 | Drug delivery medical device |
US8740843B2 (en) * | 2009-04-13 | 2014-06-03 | Cook Medical Technologies Llc | Coated balloon catheter |
EP3366326A1 (en) | 2009-04-17 | 2018-08-29 | Micell Technologies, Inc. | Stents having controlled elution |
EP2243501A1 (en) * | 2009-04-24 | 2010-10-27 | Eurocor Gmbh | Shellac and paclitaxel coated catheter balloons |
JP5767226B2 (en) * | 2009-08-27 | 2015-08-19 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Medical device |
US20120232640A1 (en) | 2009-11-19 | 2012-09-13 | Blue Medical Devices Bv | Narrow profile composition-releasing expandable medical balloon catheter |
WO2011091100A1 (en) | 2010-01-21 | 2011-07-28 | Boston Scientific Scimed, Inc. | Balloon catheters with therapeutic agent in balloon folds and methods of making the same |
WO2011097103A1 (en) | 2010-02-02 | 2011-08-11 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
US9199066B2 (en) | 2010-03-12 | 2015-12-01 | Quattro Vascular Pte Ltd. | Device and method for compartmental vessel treatment |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
US10285568B2 (en) * | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
US20110301565A1 (en) * | 2010-06-07 | 2011-12-08 | Boston Scientific Scimed, Inc. | Medical balloons having a sheath designed to facilitate release of therapeutic agent |
US10596355B2 (en) | 2010-06-30 | 2020-03-24 | Surmodics, Inc. | Catheter assembly |
CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
WO2012026717A2 (en) * | 2010-08-25 | 2012-03-01 | (주)이화바이오메딕스 | Balloon catheter in which film for drug delivery is provided |
US10780251B2 (en) * | 2010-09-17 | 2020-09-22 | W. L. Gore & Associates, Inc. | Expandable medical devices |
CA2821728A1 (en) | 2010-12-16 | 2012-06-21 | Ams Research Corporation | Micro-needle bladder balloon |
US9061127B2 (en) * | 2011-04-29 | 2015-06-23 | Boston Scientific Scimed, Inc. | Protective surfaces for drug-coated medical devices |
US8795228B2 (en) * | 2011-05-05 | 2014-08-05 | Boston Scientific Scimed, Inc. | Drug delivery device with sheath for improved drug delivery |
WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US9370643B2 (en) * | 2011-06-23 | 2016-06-21 | W.L. Gore & Associates, Inc. | High strength balloon cover |
US10016579B2 (en) * | 2011-06-23 | 2018-07-10 | W.L. Gore & Associates, Inc. | Controllable inflation profile balloon cover apparatus |
US20220032015A1 (en) * | 2011-06-23 | 2022-02-03 | W. L. Gore & Associates, Inc. | Controllable inflation profile balloon cover methods |
US9370647B2 (en) | 2011-07-14 | 2016-06-21 | W. L. Gore & Associates, Inc. | Expandable medical devices |
US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
US9730726B2 (en) | 2011-10-07 | 2017-08-15 | W. L. Gore & Associates, Inc. | Balloon assemblies having controllably variable topographies |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
TWI590843B (en) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | Films and methods of manufacture |
DE102012001188A1 (en) * | 2012-01-24 | 2013-07-25 | Qualimed Innovative Medizinprodukte Gmbh | balloon catheter |
WO2013114201A1 (en) | 2012-02-01 | 2013-08-08 | Tanhum Feld | Device for compartmental dilatation of blood vessels |
SG11201403915XA (en) | 2012-02-08 | 2014-08-28 | Quattro Vascular Pte Ltd | Constraining structure with non-linear axial struts |
US9216033B2 (en) * | 2012-02-08 | 2015-12-22 | Quattro Vascular Pte Ltd. | System and method for treating biological vessels |
CN104245038B (en) * | 2012-03-09 | 2017-05-31 | 明讯科技有限公司 | The medical sacculus of the radiation impermeable part with common extrusion |
US20150110719A1 (en) * | 2012-05-08 | 2015-04-23 | Health Line International Corp. | Hydrogel based delivery and sensor |
US9878132B2 (en) | 2012-06-15 | 2018-01-30 | W. L. Gore & Associates, Inc. | Vascular occlusion and drug delivery devices, systems, and methods |
US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
JP6162932B2 (en) * | 2012-06-29 | 2017-07-12 | フクダ電子株式会社 | Balloon catheter and balloon catheter manufacturing method |
US11504450B2 (en) | 2012-10-26 | 2022-11-22 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
CN104936629A (en) | 2012-10-26 | 2015-09-23 | 优敦力公司 | Drug coated balloon catheters for nonvascular strictures |
US10881839B2 (en) | 2012-10-26 | 2021-01-05 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
US10898700B2 (en) | 2012-10-26 | 2021-01-26 | Urotronic, Inc. | Balloon catheters for body lumens |
US10806830B2 (en) | 2012-10-26 | 2020-10-20 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
US10850076B2 (en) | 2012-10-26 | 2020-12-01 | Urotronic, Inc. | Balloon catheters for body lumens |
US11938287B2 (en) | 2012-10-26 | 2024-03-26 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
US10010654B2 (en) | 2012-10-30 | 2018-07-03 | W. L. Gore & Associates, Inc. | Sleeve for medical device assembly |
WO2014100030A1 (en) * | 2012-12-18 | 2014-06-26 | California Institute Of Technology | Drug-eluting angioplasty balloon systems |
US20140243846A1 (en) * | 2013-02-26 | 2014-08-28 | Cook Medical Technologies Llc | Balloon Catheter and Method of Use Thereof |
WO2014133708A1 (en) * | 2013-02-26 | 2014-09-04 | Cook Medical Technologies Llc | Balloon catheter |
AU2014248508B2 (en) | 2013-03-12 | 2018-11-08 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
JP6090852B2 (en) * | 2013-04-02 | 2017-03-08 | テルモ株式会社 | Balloon catheter |
CN105307716B (en) * | 2013-05-03 | 2021-09-14 | C·R·巴德公司 | Strippable protective sleeve |
JP2016519965A (en) | 2013-05-15 | 2016-07-11 | マイセル・テクノロジーズ,インコーポレイテッド | Bioabsorbable biomedical implant |
CN105555328B (en) | 2013-06-21 | 2019-01-11 | 德普伊新特斯产品公司 | film and manufacturing method |
WO2015103097A1 (en) * | 2014-01-02 | 2015-07-09 | Boston Scientific Scimed, Inc. | Drug eluting balloon with preferred drug orientation to improve drug transfer efficiency |
US10525171B2 (en) | 2014-01-24 | 2020-01-07 | The Spectranetics Corporation | Coatings for medical devices |
WO2015187872A1 (en) | 2014-06-04 | 2015-12-10 | Cagent Vascular, Llc | Cage for medical balloon |
US20150367112A1 (en) * | 2014-06-20 | 2015-12-24 | Daniel Gelbart | Medical Balloon with Reduced Straightening Force |
JP5758029B1 (en) * | 2014-06-25 | 2015-08-05 | 日出夫 文山 | Body fluid flow non-blocking balloon catheter |
LT3200860T (en) * | 2014-10-02 | 2021-05-10 | Aachen Scientific International Pte. Ltd. | Cutback method for intravascular dilation catheter |
CA2965376A1 (en) * | 2014-10-22 | 2016-04-28 | Jmd Innovation Inc. | Anti-adhesion intrauterine balloon |
WO2016073511A1 (en) * | 2014-11-03 | 2016-05-12 | Cagent Vascular, Llc | Medical balloon |
CN107405475B (en) | 2014-11-03 | 2020-09-15 | 开金血管有限公司 | Sawtooth air bag |
US10232148B2 (en) | 2014-11-17 | 2019-03-19 | TriReme Medical, LLC | Balloon catheter system and method of using same |
CN104436421B (en) * | 2014-11-28 | 2017-12-01 | 刘宗军 | One kind can dabbling drug sacculus |
KR101663805B1 (en) | 2014-12-03 | 2016-10-14 | 연세대학교 산학협력단 | Balloon Catheter Having Micro Needles and Manufacturing Method Thereof |
US11904072B2 (en) | 2015-04-24 | 2024-02-20 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
EP3285820A4 (en) | 2015-04-24 | 2018-12-12 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
EP3103501A1 (en) * | 2015-06-12 | 2016-12-14 | Arravasc Limited | A drug coated angioplasty balloon |
EP3326678A4 (en) | 2015-07-22 | 2019-04-17 | Olympus Corporation | Endoscope treatment tool |
US10166374B2 (en) | 2015-09-17 | 2019-01-01 | Cagent Vascular, Llc | Wedge dissectors for a medical balloon |
US10105519B2 (en) * | 2015-10-20 | 2018-10-23 | C.R. Bard, Inc. | Variable diameter medical balloon |
JP6788964B2 (en) * | 2015-11-26 | 2020-11-25 | フクダ電子株式会社 | Catheter Balloon manufacturing method and balloon catheter |
CN114225119A (en) * | 2016-02-08 | 2022-03-25 | 祥丰医疗私人有限公司 | Expandable balloon comprising a coating |
US10792477B2 (en) * | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
EP3406294B1 (en) * | 2016-03-23 | 2023-06-28 | Terumo Kabushiki Kaisha | Balloon catheter and production method therefor, and treatment method |
WO2018060466A1 (en) | 2016-09-30 | 2018-04-05 | Arravasc Limited | Finned angioplasty balloon |
US10874826B2 (en) | 2016-10-05 | 2020-12-29 | Terumo Corporation | Balloon catheter systems |
JP2018068724A (en) * | 2016-10-31 | 2018-05-10 | 株式会社カネカ | Balloon catheter |
CN110114108B (en) | 2016-11-16 | 2022-12-06 | 开金血管公司 | System and method for depositing a drug into tissue through teeth |
EP3558408A1 (en) | 2016-12-22 | 2019-10-30 | Biotronik AG | Intratumoral drug delivery materials and methods for treating breast cancer |
JP2021036924A (en) * | 2017-12-27 | 2021-03-11 | テルモ株式会社 | Balloon catheter |
US10688287B2 (en) | 2018-01-19 | 2020-06-23 | Medtronic, Inc. | Sheath including sheath body and sheath insert |
US10737071B2 (en) | 2018-01-19 | 2020-08-11 | Medtronic, Inc. | Splittable sheath |
US10702673B2 (en) | 2018-01-19 | 2020-07-07 | Medtronic Vascular, Inc. | Expandable balloon sheaths |
US10682492B2 (en) | 2018-01-19 | 2020-06-16 | Medtronic Vascular, Inc. | Expandable balloon sheath |
US10668255B2 (en) | 2018-01-19 | 2020-06-02 | Medtronic Vascular, Inc. | Sheath for medically expandable balloon |
CN108187212B (en) * | 2018-03-14 | 2022-07-15 | 董鹏 | Medicine balloon |
US10935149B2 (en) | 2018-03-15 | 2021-03-02 | University Of Washington | Temperature-actuated valve, fluidic device, and related methods of use |
WO2019182131A1 (en) * | 2018-03-23 | 2019-09-26 | テルモ株式会社 | Medical device and method of applying medicament |
JP2021530324A (en) | 2018-07-25 | 2021-11-11 | ケイジェント ヴァスキュラー, インコーポレイテッド | Medical balloon catheter with improved push performance |
US11389627B1 (en) | 2018-10-02 | 2022-07-19 | Lutonix Inc. | Balloon protectors, balloon-catheter assemblies, and methods thereof |
CN112089951A (en) * | 2019-06-18 | 2020-12-18 | 微创神通医疗科技(上海)有限公司 | Medical balloon, balloon catheter and medical device |
WO2021161545A1 (en) * | 2020-02-14 | 2021-08-19 | 日本ライフライン株式会社 | Drug delivery balloon catheter |
CN111298274B (en) * | 2020-05-14 | 2020-09-22 | 上海脉全医疗器械有限公司 | Medicine balloon and using method thereof |
CN113350648A (en) * | 2021-07-18 | 2021-09-07 | 温州医科大学附属第一医院 | Tracheal catheter capable of accurately local anesthesia |
Citations (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4417576A (en) * | 1982-02-25 | 1983-11-29 | Baran Ostap E | Double-wall surgical cuff |
US4423725A (en) * | 1982-03-31 | 1984-01-03 | Baran Ostap E | Multiple surgical cuff |
US4994033A (en) * | 1989-05-25 | 1991-02-19 | Schneider (Usa) Inc. | Intravascular drug delivery dilatation catheter |
US4994072A (en) * | 1988-08-31 | 1991-02-19 | Meadox Medicals, Inc. | Dilation catheter |
US5015231A (en) * | 1989-04-21 | 1991-05-14 | Scimed Life Systems, Inc. | Multipart split sleeve balloon protector for dilatation catheter |
US5042976A (en) * | 1987-01-13 | 1991-08-27 | Terumo Kabushiki Kaisha | Balloon catheter and manufacturing method of the same |
US5049132A (en) * | 1990-01-08 | 1991-09-17 | Cordis Corporation | Balloon catheter for delivering therapeutic agents |
US5091205A (en) * | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
US5092841A (en) * | 1990-05-17 | 1992-03-03 | Wayne State University | Method for treating an arterial wall injured during angioplasty |
US5100386A (en) * | 1988-10-28 | 1992-03-31 | Kanji Inoue | Balloon catheter assembly |
US5102402A (en) * | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
US5141494A (en) * | 1990-02-15 | 1992-08-25 | Danforth Biomedical, Inc. | Variable wire diameter angioplasty dilatation balloon catheter |
US5196024A (en) * | 1990-07-03 | 1993-03-23 | Cedars-Sinai Medical Center | Balloon catheter with cutting edge |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5213576A (en) * | 1991-06-11 | 1993-05-25 | Cordis Corporation | Therapeutic porous balloon catheter |
US5226913A (en) * | 1988-09-01 | 1993-07-13 | Corvita Corporation | Method of making a radially expandable prosthesis |
US5232444A (en) * | 1988-06-25 | 1993-08-03 | Just Hansjoerg | Dilatation catheter |
US5292321A (en) * | 1990-06-08 | 1994-03-08 | Lee Benjamin I | Thermal balloon angioplasty with thermoplastic stent |
US5295959A (en) * | 1992-03-13 | 1994-03-22 | Medtronic, Inc. | Autoperfusion dilatation catheter having a bonded channel |
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5320604A (en) * | 1991-04-24 | 1994-06-14 | Baxter International Inc. | Low-profile single-lumen dual-balloon catheter with integrated guide wire for embolectomy dilatation/occlusion and delivery of treatment fluid |
US5324261A (en) * | 1991-01-04 | 1994-06-28 | Medtronic, Inc. | Drug delivery balloon catheter with line of weakness |
US5348538A (en) * | 1992-09-29 | 1994-09-20 | Scimed Life Systems, Inc. | Shrinking balloon catheter having nonlinear or hybrid compliance curve |
US5352236A (en) * | 1992-09-29 | 1994-10-04 | Medtronic, Inc. | Balloon protector |
US5364356A (en) * | 1993-07-19 | 1994-11-15 | Bavaria Medizin Technologie Gmbh | Sleeve catheter |
US5383928A (en) * | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
US5397307A (en) * | 1993-12-07 | 1995-03-14 | Schneider (Usa) Inc. | Drug delivery PTCA catheter and method for drug delivery |
US5447497A (en) * | 1992-08-06 | 1995-09-05 | Scimed Life Systems, Inc | Balloon catheter having nonlinear compliance curve and method of using |
US5456666A (en) * | 1994-04-26 | 1995-10-10 | Boston Scientific Corp | Medical balloon folding into predetermined shapes and method |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5498238A (en) * | 1990-06-15 | 1996-03-12 | Cortrak Medical, Inc. | Simultaneous angioplasty and phoretic drug delivery |
US5499971A (en) * | 1990-06-15 | 1996-03-19 | Cortrak Medical, Inc. | Method for iontophoretically delivering drug adjacent to a heart |
US5501662A (en) * | 1992-05-22 | 1996-03-26 | Genetronics, Inc. | Implantable electroporation method and apparatus for drug and gene delivery |
US5505700A (en) * | 1994-06-14 | 1996-04-09 | Cordis Corporation | Electro-osmotic infusion catheter |
US5507724A (en) * | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5545132A (en) * | 1993-12-21 | 1996-08-13 | C. R. Bard, Inc. | Helically grooved balloon for dilatation catheter and method of using |
US5562922A (en) * | 1993-03-18 | 1996-10-08 | Cedars-Sinai Medical Center | Drug incorporating and release polymeric coating for bioprosthesis |
US5571086A (en) * | 1992-11-02 | 1996-11-05 | Localmed, Inc. | Method and apparatus for sequentially performing multiple intraluminal procedures |
US5599306A (en) * | 1994-04-01 | 1997-02-04 | Localmed, Inc. | Method and apparatus for providing external perfusion lumens on balloon catheters |
US5626600A (en) * | 1987-01-06 | 1997-05-06 | Advanced Cardiovascular Systems, Inc. | Reinforced balloon dilatation catheter with slitted exchange sleeve and method |
US5634901A (en) * | 1992-11-02 | 1997-06-03 | Localmed, Inc. | Method of using a catheter sleeve |
US5653689A (en) * | 1995-09-30 | 1997-08-05 | Abacus Design & Development, Inc. | Infusion catheter |
US5674192A (en) * | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5693014A (en) * | 1993-08-23 | 1997-12-02 | Boston Scientific Corporation | Balloon catheter |
US5704908A (en) * | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
US5707358A (en) * | 1996-05-13 | 1998-01-13 | Wright; John T. M. | Dual concentric balloon catheter for retrograde cardioplegia perfusion |
US5707385A (en) * | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
US5738901A (en) * | 1993-09-20 | 1998-04-14 | Scimed Life Systems, Inc. | Catheter balloon with retraction coating |
US5746745A (en) * | 1993-08-23 | 1998-05-05 | Boston Scientific Corporation | Balloon catheter |
US5749915A (en) * | 1988-08-24 | 1998-05-12 | Focal, Inc. | Polymeric endoluminal paving process |
US5810870A (en) * | 1993-08-18 | 1998-09-22 | W. L. Gore & Associates, Inc. | Intraluminal stent graft |
US5833651A (en) * | 1996-11-08 | 1998-11-10 | Medtronic, Inc. | Therapeutic intraluminal stents |
US5833659A (en) * | 1996-07-10 | 1998-11-10 | Cordis Corporation | Infusion balloon catheter |
US5843089A (en) * | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
US5893840A (en) * | 1991-01-04 | 1999-04-13 | Medtronic, Inc. | Releasable microcapsules on balloon catheters |
US5941871A (en) * | 1996-11-14 | 1999-08-24 | Scimed Life Systems, Inc. | Catheter systems with interchangeable parts |
US5947925A (en) * | 1996-03-18 | 1999-09-07 | Hiroaki Ashiya | Catheter assembly |
US5964730A (en) * | 1996-08-15 | 1999-10-12 | Advanced Cardiovascular Systems, Inc. | Protective sheath for catheter balloons |
US6129706A (en) * | 1998-12-10 | 2000-10-10 | Janacek; Jaroslav | Corrugated catheter balloon |
US6135982A (en) * | 1997-10-03 | 2000-10-24 | Boston Scientific Corporation | Balloon catheterization |
US6149641A (en) * | 1997-08-21 | 2000-11-21 | Scimed Life Systems, Inc. | Local delivery of estrogen for angiogenesis |
US6280411B1 (en) * | 1998-05-18 | 2001-08-28 | Scimed Life Systems, Inc. | Localized delivery of drug agents |
US6364856B1 (en) * | 1998-04-14 | 2002-04-02 | Boston Scientific Corporation | Medical device with sponge coating for controlled drug release |
US6369039B1 (en) * | 1998-06-30 | 2002-04-09 | Scimed Life Sytems, Inc. | High efficiency local drug delivery |
US6450989B2 (en) * | 1998-04-27 | 2002-09-17 | Artemis Medical, Inc. | Dilating and support apparatus with disease inhibitors and methods for use |
US6544223B1 (en) * | 2001-01-05 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Balloon catheter for delivering therapeutic agents |
US6544221B1 (en) * | 2000-08-30 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Balloon designs for drug delivery |
US6547803B2 (en) * | 2001-09-20 | 2003-04-15 | The Regents Of The University Of California | Microfabricated surgical device for interventional procedures |
US20030077310A1 (en) * | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US6593130B1 (en) * | 1999-04-16 | 2003-07-15 | The Regents Of The University Of California | Method and apparatus for ex vivo and in vivo cellular electroporation of gene protein or drug therapy |
US6638246B1 (en) * | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
US6652581B1 (en) * | 1998-07-07 | 2003-11-25 | Boston Scientific Scimed, Inc. | Medical device with porous surface for controlled drug release and method of making the same |
US6656155B2 (en) * | 2001-12-17 | 2003-12-02 | Scimed Life Systems, Inc. | Catheter for endoluminal delivery of therapeutic agents that minimizes loss of therapeutic |
US6656162B2 (en) * | 1999-11-17 | 2003-12-02 | Microchips, Inc. | Implantable drug delivery stents |
US20040049259A1 (en) * | 1992-07-08 | 2004-03-11 | Strecker Ernst Peter | Endoprosthesis that can be percutaneously implanted in the patient's body |
US6743388B2 (en) * | 2001-12-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Process of making polymer articles |
US20040127978A1 (en) * | 2002-08-13 | 2004-07-01 | Medtronic, Inc. | Active agent delivery system including a hydrophilic polymer, medical device, and method |
US6765059B2 (en) * | 1999-07-14 | 2004-07-20 | Biotronik Mess-Und Therapiegeraete Gmbh & Co. Ingenieurbuero Berlin | Polymer material |
US20040181252A1 (en) * | 1999-11-19 | 2004-09-16 | Boyle Christopher T. | Balloon catheter having metal balloon and method of making same |
US6796958B2 (en) * | 1994-07-25 | 2004-09-28 | Advanced Cardiovascular Systems, Inc. | Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters |
US20040215227A1 (en) * | 2002-02-28 | 2004-10-28 | Scimed Life Systems, Inc | Balloon folding apparatus, methods and products |
US20050015046A1 (en) * | 2003-07-18 | 2005-01-20 | Scimed Life Systems, Inc. | Medical devices and processes for preparing same |
US20050182361A1 (en) * | 1998-05-18 | 2005-08-18 | Boston Scientific Scimed, Inc. | Localized delivery of drug agents |
US6939320B2 (en) * | 1998-05-18 | 2005-09-06 | Boston Scientific Scimed., Inc. | Localized delivery of drug agents |
US20050228417A1 (en) * | 2004-03-26 | 2005-10-13 | Teitelbaum George P | Devices and methods for removing a matter from a body cavity of a patient |
US20050273049A1 (en) * | 2004-06-08 | 2005-12-08 | Peter Krulevitch | Drug delivery device using microprojections |
US6991617B2 (en) * | 2002-08-21 | 2006-01-31 | Hektner Thomas R | Vascular treatment method and device |
US20060079836A1 (en) * | 2004-10-12 | 2006-04-13 | Holman Thomas J | Reinforced and drug-eluting balloon catheters and methods for making same |
US7048714B2 (en) * | 2002-10-30 | 2006-05-23 | Biorest Ltd. | Drug eluting medical device with an expandable portion for drug release |
US20060127442A1 (en) * | 2004-12-09 | 2006-06-15 | Helmus Michael N | Use of supercritical fluids to incorporate biologically active agents into nanoporous medical articles |
US7081113B2 (en) * | 2003-06-26 | 2006-07-25 | Depuy Acromed, Inc. | Helical probe |
US20060167407A1 (en) * | 2005-01-26 | 2006-07-27 | Jan Weber | Medical devices and methods of making the same |
US20060184112A1 (en) * | 2005-02-17 | 2006-08-17 | Horn Daniel J | Medical devices |
US20060190022A1 (en) * | 2004-07-14 | 2006-08-24 | By-Pass, Inc. | Material delivery system |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU1069826A1 (en) | 1982-09-17 | 1984-01-30 | Запорожский медицинский институт | Endotracheal tube |
US5807306A (en) * | 1992-11-09 | 1998-09-15 | Cortrak Medical, Inc. | Polymer matrix drug delivery apparatus |
WO1994023787A1 (en) * | 1993-04-22 | 1994-10-27 | Rammler David H | Sampling balloon catheter |
US6027779A (en) * | 1993-08-18 | 2000-02-22 | W. L. Gore & Associates, Inc. | Thin-wall polytetrafluoroethylene tube |
US5601589A (en) * | 1994-06-29 | 1997-02-11 | General Surgical Innovations, Inc. | Extraluminal balloon dissection apparatus and method |
US6124007A (en) * | 1996-03-06 | 2000-09-26 | Scimed Life Systems Inc | Laminate catheter balloons with additive burst strength and methods for preparation of same |
EP0835673A3 (en) | 1996-10-10 | 1998-09-23 | Schneider (Usa) Inc. | Catheter for tissue dilatation and drug delivery |
US6306166B1 (en) * | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
US6299980B1 (en) | 1998-09-29 | 2001-10-09 | Medtronic Ave, Inc. | One step lubricious coating |
JP2001009037A (en) | 1999-06-25 | 2001-01-16 | Terumo Corp | Balloon for dilation of narrow segment and balloon catheter |
DE10244847A1 (en) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medical device for drug delivery |
WO2004060471A1 (en) | 2003-01-02 | 2004-07-22 | Novoste Corporation | Drug delivery balloon catheter |
US7364585B2 (en) * | 2003-08-11 | 2008-04-29 | Boston Scientific Scimed, Inc. | Medical devices comprising drug-loaded capsules for localized drug delivery |
US7166099B2 (en) * | 2003-08-21 | 2007-01-23 | Boston Scientific Scimed, Inc. | Multilayer medical devices |
WO2005027996A2 (en) | 2003-09-15 | 2005-03-31 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
WO2005037339A1 (en) | 2003-10-14 | 2005-04-28 | Cube Medical A/S | A balloon for use in angioplasty |
JP4443278B2 (en) | 2004-03-26 | 2010-03-31 | テルモ株式会社 | Catheter with expansion body |
WO2005105171A1 (en) * | 2004-04-29 | 2005-11-10 | Cube Medical A/S | A balloon for use in angioplasty with an outer layer of nanofibers |
WO2005113058A1 (en) | 2004-05-21 | 2005-12-01 | Medtronic Vascular Inc. | Folded balloon for catheter |
US20060025848A1 (en) * | 2004-07-29 | 2006-02-02 | Jan Weber | Medical device having a coating layer with structural elements therein and method of making the same |
US8672990B2 (en) * | 2005-05-27 | 2014-03-18 | Boston Scientific Scimed, Inc. | Fiber mesh controlled expansion balloon catheter |
US8795348B2 (en) | 2005-06-14 | 2014-08-05 | Boston Scientific Scimed, Inc. | Medical devices and related methods |
WO2007053728A1 (en) * | 2005-11-01 | 2007-05-10 | Cook Incorporated | Angioplasty cutting device and method |
US20070112300A1 (en) | 2005-11-14 | 2007-05-17 | Roman Ricardo D | Balloon folding design, apparatus and method of making the same |
US20070184085A1 (en) * | 2006-02-03 | 2007-08-09 | Boston Scientific Scimed, Inc. | Ultrasound activated medical device |
EP3150236B1 (en) * | 2006-02-09 | 2018-12-26 | B. Braun Melsungen AG | Coating method for a folded balloon |
US20070191811A1 (en) | 2006-02-10 | 2007-08-16 | Joseph Berglund | System and Method for Treating a Vascular Condition |
US7572625B2 (en) * | 2006-05-18 | 2009-08-11 | Boston Scientific Scimed, Inc. | Medical devices coated with drug carrier macromolecules |
US20080097300A1 (en) | 2006-08-07 | 2008-04-24 | Sherif Eskaros | Catheter balloon with multiple micropleats |
US20080033476A1 (en) * | 2006-08-07 | 2008-02-07 | Greene Joel M | Catheter balloon with controlled failure sheath |
US20080140002A1 (en) | 2006-12-06 | 2008-06-12 | Kamal Ramzipoor | System for delivery of biologically active substances with actuating three dimensional surface |
NZ588816A (en) | 2007-01-21 | 2011-11-25 | Hemoteq Ag | Medical device for the treatment of stenoses of corporal lumina and for the prevention of impending restenoses |
US9370642B2 (en) | 2007-06-29 | 2016-06-21 | J.W. Medical Systems Ltd. | Adjustable-length drug delivery balloon |
US20090105687A1 (en) | 2007-10-05 | 2009-04-23 | Angioscore, Inc. | Scoring catheter with drug delivery membrane |
EP2262565A1 (en) | 2008-03-06 | 2010-12-22 | Boston Scientific Scimed, Inc. | Balloon catheter devices with sheath covering |
EP2106820A1 (en) | 2008-03-31 | 2009-10-07 | Torsten Heilmann | Expansible biocompatible coats comprising a biologically active substance |
JP5767226B2 (en) * | 2009-08-27 | 2015-08-19 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Medical device |
-
2009
- 2009-03-06 EP EP09716409A patent/EP2262565A1/en not_active Withdrawn
- 2009-03-06 WO PCT/US2009/036349 patent/WO2009111709A2/en active Application Filing
- 2009-03-06 JP JP2010549915A patent/JP2011513005A/en active Pending
- 2009-03-06 EP EP13155418.0A patent/EP2594311A3/en not_active Withdrawn
- 2009-03-06 US US12/399,548 patent/US8114049B2/en not_active Expired - Fee Related
- 2009-03-06 EP EP09716422A patent/EP2262566A1/en not_active Withdrawn
- 2009-03-06 EP EP09717854A patent/EP2262547B1/en not_active Not-in-force
- 2009-03-06 US US12/399,386 patent/US20090227948A1/en not_active Abandoned
- 2009-03-06 WO PCT/US2009/036354 patent/WO2009111712A1/en active Application Filing
- 2009-03-06 CA CA2716985A patent/CA2716985A1/en not_active Abandoned
- 2009-03-06 US US12/399,532 patent/US20090226502A1/en not_active Abandoned
- 2009-03-06 WO PCT/US2009/036359 patent/WO2009111716A1/en active Application Filing
- 2009-03-06 JP JP2010549914A patent/JP2011513004A/en active Pending
-
2011
- 2011-07-08 US US13/179,054 patent/US20110270226A1/en not_active Abandoned
- 2011-11-04 US US13/289,490 patent/US20120053517A1/en not_active Abandoned
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4417576A (en) * | 1982-02-25 | 1983-11-29 | Baran Ostap E | Double-wall surgical cuff |
US4423725A (en) * | 1982-03-31 | 1984-01-03 | Baran Ostap E | Multiple surgical cuff |
US5626600A (en) * | 1987-01-06 | 1997-05-06 | Advanced Cardiovascular Systems, Inc. | Reinforced balloon dilatation catheter with slitted exchange sleeve and method |
US5042976A (en) * | 1987-01-13 | 1991-08-27 | Terumo Kabushiki Kaisha | Balloon catheter and manufacturing method of the same |
US5232444A (en) * | 1988-06-25 | 1993-08-03 | Just Hansjoerg | Dilatation catheter |
US5749915A (en) * | 1988-08-24 | 1998-05-12 | Focal, Inc. | Polymeric endoluminal paving process |
US4994072A (en) * | 1988-08-31 | 1991-02-19 | Meadox Medicals, Inc. | Dilation catheter |
US5226913A (en) * | 1988-09-01 | 1993-07-13 | Corvita Corporation | Method of making a radially expandable prosthesis |
US5100386A (en) * | 1988-10-28 | 1992-03-31 | Kanji Inoue | Balloon catheter assembly |
US5091205A (en) * | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
US5015231A (en) * | 1989-04-21 | 1991-05-14 | Scimed Life Systems, Inc. | Multipart split sleeve balloon protector for dilatation catheter |
US4994033A (en) * | 1989-05-25 | 1991-02-19 | Schneider (Usa) Inc. | Intravascular drug delivery dilatation catheter |
US5049132A (en) * | 1990-01-08 | 1991-09-17 | Cordis Corporation | Balloon catheter for delivering therapeutic agents |
US5141494A (en) * | 1990-02-15 | 1992-08-25 | Danforth Biomedical, Inc. | Variable wire diameter angioplasty dilatation balloon catheter |
US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5092841A (en) * | 1990-05-17 | 1992-03-03 | Wayne State University | Method for treating an arterial wall injured during angioplasty |
US5292321A (en) * | 1990-06-08 | 1994-03-08 | Lee Benjamin I | Thermal balloon angioplasty with thermoplastic stent |
US5499971A (en) * | 1990-06-15 | 1996-03-19 | Cortrak Medical, Inc. | Method for iontophoretically delivering drug adjacent to a heart |
US5498238A (en) * | 1990-06-15 | 1996-03-12 | Cortrak Medical, Inc. | Simultaneous angioplasty and phoretic drug delivery |
US5196024A (en) * | 1990-07-03 | 1993-03-23 | Cedars-Sinai Medical Center | Balloon catheter with cutting edge |
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5674192A (en) * | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5843089A (en) * | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
US5324261A (en) * | 1991-01-04 | 1994-06-28 | Medtronic, Inc. | Drug delivery balloon catheter with line of weakness |
US5893840A (en) * | 1991-01-04 | 1999-04-13 | Medtronic, Inc. | Releasable microcapsules on balloon catheters |
US5370614A (en) * | 1991-01-04 | 1994-12-06 | Medtronic, Inc. | Method for making a drug delivery balloon catheter |
US5102402A (en) * | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
US5320604A (en) * | 1991-04-24 | 1994-06-14 | Baxter International Inc. | Low-profile single-lumen dual-balloon catheter with integrated guide wire for embolectomy dilatation/occlusion and delivery of treatment fluid |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5213576A (en) * | 1991-06-11 | 1993-05-25 | Cordis Corporation | Therapeutic porous balloon catheter |
US5295959A (en) * | 1992-03-13 | 1994-03-22 | Medtronic, Inc. | Autoperfusion dilatation catheter having a bonded channel |
US5501662A (en) * | 1992-05-22 | 1996-03-26 | Genetronics, Inc. | Implantable electroporation method and apparatus for drug and gene delivery |
US5383928A (en) * | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
US5507724A (en) * | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
US20040049259A1 (en) * | 1992-07-08 | 2004-03-11 | Strecker Ernst Peter | Endoprosthesis that can be percutaneously implanted in the patient's body |
US5447497A (en) * | 1992-08-06 | 1995-09-05 | Scimed Life Systems, Inc | Balloon catheter having nonlinear compliance curve and method of using |
US5352236A (en) * | 1992-09-29 | 1994-10-04 | Medtronic, Inc. | Balloon protector |
US5348538A (en) * | 1992-09-29 | 1994-09-20 | Scimed Life Systems, Inc. | Shrinking balloon catheter having nonlinear or hybrid compliance curve |
US5634901A (en) * | 1992-11-02 | 1997-06-03 | Localmed, Inc. | Method of using a catheter sleeve |
US5571086A (en) * | 1992-11-02 | 1996-11-05 | Localmed, Inc. | Method and apparatus for sequentially performing multiple intraluminal procedures |
US5562922A (en) * | 1993-03-18 | 1996-10-08 | Cedars-Sinai Medical Center | Drug incorporating and release polymeric coating for bioprosthesis |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5624411A (en) * | 1993-04-26 | 1997-04-29 | Medtronic, Inc. | Intravascular stent and method |
US5679400A (en) * | 1993-04-26 | 1997-10-21 | Medtronic, Inc. | Intravascular stent and method |
US5364356A (en) * | 1993-07-19 | 1994-11-15 | Bavaria Medizin Technologie Gmbh | Sleeve catheter |
US5810870A (en) * | 1993-08-18 | 1998-09-22 | W. L. Gore & Associates, Inc. | Intraluminal stent graft |
US5746745A (en) * | 1993-08-23 | 1998-05-05 | Boston Scientific Corporation | Balloon catheter |
US5693014A (en) * | 1993-08-23 | 1997-12-02 | Boston Scientific Corporation | Balloon catheter |
US5738901A (en) * | 1993-09-20 | 1998-04-14 | Scimed Life Systems, Inc. | Catheter balloon with retraction coating |
US5397307A (en) * | 1993-12-07 | 1995-03-14 | Schneider (Usa) Inc. | Drug delivery PTCA catheter and method for drug delivery |
US5545132A (en) * | 1993-12-21 | 1996-08-13 | C. R. Bard, Inc. | Helically grooved balloon for dilatation catheter and method of using |
US5599306A (en) * | 1994-04-01 | 1997-02-04 | Localmed, Inc. | Method and apparatus for providing external perfusion lumens on balloon catheters |
US5456666A (en) * | 1994-04-26 | 1995-10-10 | Boston Scientific Corp | Medical balloon folding into predetermined shapes and method |
US5505700A (en) * | 1994-06-14 | 1996-04-09 | Cordis Corporation | Electro-osmotic infusion catheter |
US6796958B2 (en) * | 1994-07-25 | 2004-09-28 | Advanced Cardiovascular Systems, Inc. | Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters |
US5707385A (en) * | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
US5653689A (en) * | 1995-09-30 | 1997-08-05 | Abacus Design & Development, Inc. | Infusion catheter |
US5947925A (en) * | 1996-03-18 | 1999-09-07 | Hiroaki Ashiya | Catheter assembly |
US5707358A (en) * | 1996-05-13 | 1998-01-13 | Wright; John T. M. | Dual concentric balloon catheter for retrograde cardioplegia perfusion |
US5833659A (en) * | 1996-07-10 | 1998-11-10 | Cordis Corporation | Infusion balloon catheter |
US5964730A (en) * | 1996-08-15 | 1999-10-12 | Advanced Cardiovascular Systems, Inc. | Protective sheath for catheter balloons |
US5704908A (en) * | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
US5833651A (en) * | 1996-11-08 | 1998-11-10 | Medtronic, Inc. | Therapeutic intraluminal stents |
US5941871A (en) * | 1996-11-14 | 1999-08-24 | Scimed Life Systems, Inc. | Catheter systems with interchangeable parts |
US6149641A (en) * | 1997-08-21 | 2000-11-21 | Scimed Life Systems, Inc. | Local delivery of estrogen for angiogenesis |
US6517514B1 (en) * | 1997-10-03 | 2003-02-11 | Boston Scientific Corporation | Balloon catheterization |
US6135982A (en) * | 1997-10-03 | 2000-10-24 | Boston Scientific Corporation | Balloon catheterization |
US6364856B1 (en) * | 1998-04-14 | 2002-04-02 | Boston Scientific Corporation | Medical device with sponge coating for controlled drug release |
US6450989B2 (en) * | 1998-04-27 | 2002-09-17 | Artemis Medical, Inc. | Dilating and support apparatus with disease inhibitors and methods for use |
US6280411B1 (en) * | 1998-05-18 | 2001-08-28 | Scimed Life Systems, Inc. | Localized delivery of drug agents |
US6939320B2 (en) * | 1998-05-18 | 2005-09-06 | Boston Scientific Scimed., Inc. | Localized delivery of drug agents |
US20050182361A1 (en) * | 1998-05-18 | 2005-08-18 | Boston Scientific Scimed, Inc. | Localized delivery of drug agents |
US6369039B1 (en) * | 1998-06-30 | 2002-04-09 | Scimed Life Sytems, Inc. | High efficiency local drug delivery |
US6652581B1 (en) * | 1998-07-07 | 2003-11-25 | Boston Scientific Scimed, Inc. | Medical device with porous surface for controlled drug release and method of making the same |
US6129706A (en) * | 1998-12-10 | 2000-10-10 | Janacek; Jaroslav | Corrugated catheter balloon |
US6593130B1 (en) * | 1999-04-16 | 2003-07-15 | The Regents Of The University Of California | Method and apparatus for ex vivo and in vivo cellular electroporation of gene protein or drug therapy |
US6765059B2 (en) * | 1999-07-14 | 2004-07-20 | Biotronik Mess-Und Therapiegeraete Gmbh & Co. Ingenieurbuero Berlin | Polymer material |
US6656162B2 (en) * | 1999-11-17 | 2003-12-02 | Microchips, Inc. | Implantable drug delivery stents |
US20040181252A1 (en) * | 1999-11-19 | 2004-09-16 | Boyle Christopher T. | Balloon catheter having metal balloon and method of making same |
US6544221B1 (en) * | 2000-08-30 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Balloon designs for drug delivery |
US6638246B1 (en) * | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
US6544223B1 (en) * | 2001-01-05 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Balloon catheter for delivering therapeutic agents |
US6547803B2 (en) * | 2001-09-20 | 2003-04-15 | The Regents Of The University Of California | Microfabricated surgical device for interventional procedures |
US20030077310A1 (en) * | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US6656155B2 (en) * | 2001-12-17 | 2003-12-02 | Scimed Life Systems, Inc. | Catheter for endoluminal delivery of therapeutic agents that minimizes loss of therapeutic |
US6743388B2 (en) * | 2001-12-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Process of making polymer articles |
US20040215227A1 (en) * | 2002-02-28 | 2004-10-28 | Scimed Life Systems, Inc | Balloon folding apparatus, methods and products |
US20040127978A1 (en) * | 2002-08-13 | 2004-07-01 | Medtronic, Inc. | Active agent delivery system including a hydrophilic polymer, medical device, and method |
US6991617B2 (en) * | 2002-08-21 | 2006-01-31 | Hektner Thomas R | Vascular treatment method and device |
US7048714B2 (en) * | 2002-10-30 | 2006-05-23 | Biorest Ltd. | Drug eluting medical device with an expandable portion for drug release |
US7081113B2 (en) * | 2003-06-26 | 2006-07-25 | Depuy Acromed, Inc. | Helical probe |
US20050015046A1 (en) * | 2003-07-18 | 2005-01-20 | Scimed Life Systems, Inc. | Medical devices and processes for preparing same |
US20050228417A1 (en) * | 2004-03-26 | 2005-10-13 | Teitelbaum George P | Devices and methods for removing a matter from a body cavity of a patient |
US20050273049A1 (en) * | 2004-06-08 | 2005-12-08 | Peter Krulevitch | Drug delivery device using microprojections |
US20060190022A1 (en) * | 2004-07-14 | 2006-08-24 | By-Pass, Inc. | Material delivery system |
US20060079836A1 (en) * | 2004-10-12 | 2006-04-13 | Holman Thomas J | Reinforced and drug-eluting balloon catheters and methods for making same |
US20060127442A1 (en) * | 2004-12-09 | 2006-06-15 | Helmus Michael N | Use of supercritical fluids to incorporate biologically active agents into nanoporous medical articles |
US20060167407A1 (en) * | 2005-01-26 | 2006-07-27 | Jan Weber | Medical devices and methods of making the same |
US20060184112A1 (en) * | 2005-02-17 | 2006-08-17 | Horn Daniel J | Medical devices |
Cited By (26)
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Also Published As
Publication number | Publication date |
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WO2009111709A2 (en) | 2009-09-11 |
WO2009111716A1 (en) | 2009-09-11 |
US20090227948A1 (en) | 2009-09-10 |
US20120053517A1 (en) | 2012-03-01 |
EP2262547A2 (en) | 2010-12-22 |
EP2262547B1 (en) | 2013-01-09 |
WO2009111709A3 (en) | 2010-07-08 |
JP2011513004A (en) | 2011-04-28 |
EP2262566A1 (en) | 2010-12-22 |
US20110270226A1 (en) | 2011-11-03 |
JP2011513005A (en) | 2011-04-28 |
US20090227949A1 (en) | 2009-09-10 |
US8114049B2 (en) | 2012-02-14 |
EP2594311A3 (en) | 2013-07-10 |
CA2716985A1 (en) | 2009-09-11 |
EP2594311A2 (en) | 2013-05-22 |
EP2262565A1 (en) | 2010-12-22 |
WO2009111712A1 (en) | 2009-09-11 |
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