US20100136209A1 - Systems and methods for applying an antimicrobial coating to a medical device - Google Patents
Systems and methods for applying an antimicrobial coating to a medical device Download PDFInfo
- Publication number
- US20100136209A1 US20100136209A1 US12/490,235 US49023509A US2010136209A1 US 20100136209 A1 US20100136209 A1 US 20100136209A1 US 49023509 A US49023509 A US 49023509A US 2010136209 A1 US2010136209 A1 US 2010136209A1
- Authority
- US
- United States
- Prior art keywords
- coating
- antimicrobial
- medical device
- composition
- acrylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/02—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
- B05D3/0254—After-treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/06—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
- B05D3/061—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation using U.V.
- B05D3/065—After-treatment
- B05D3/067—Curing or cross-linking the coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/02—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to macromolecular substances, e.g. rubber
- B05D7/04—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to macromolecular substances, e.g. rubber to surfaces of films or sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/24—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials for applying particular liquids or other fluent materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1811—C10or C11-(Meth)acrylate, e.g. isodecyl (meth)acrylate, isobornyl (meth)acrylate or 2-naphthyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/10—Esters
- C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
- C08F222/103—Esters of polyhydric alcohols or polyhydric phenols of trialcohols, e.g. trimethylolpropane tri(meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/10—Esters
- C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
- C08F222/104—Esters of polyhydric alcohols or polyhydric phenols of tetraalcohols, e.g. pentaerythritol tetra(meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
- C09D4/06—Organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups C09D159/00 - C09D187/00
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/16—Antifouling paints; Underwater paints
- C09D5/1656—Antifouling paints; Underwater paints characterised by the film-forming substance
- C09D5/1662—Synthetic film-forming substance
- C09D5/1668—Vinyl-type polymers
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M105/00—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound
- C10M105/08—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound containing oxygen
- C10M105/20—Aldehydes; Ketones
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M105/00—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound
- C10M105/08—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound containing oxygen
- C10M105/32—Esters
- C10M105/40—Esters containing free hydroxy or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M105/00—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound
- C10M105/56—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound containing nitrogen
- C10M105/58—Amines, e.g. polyalkylene polyamines, quaternary amines
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
- C10M125/04—Metals; Alloys
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
- C10M125/06—Sulfur
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
- C10M125/16—Hydrogen peroxide; Oxygenated water
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
- C10M125/20—Compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
- C10M125/26—Compounds containing silicon or boron, e.g. silica, sand
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M129/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen
- C10M129/02—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen having a carbon chain of less than 30 atoms
- C10M129/24—Aldehydes; Ketones
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M133/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M169/00—Lubricating compositions characterised by containing as components a mixture of at least two types of ingredient selected from base-materials, thickeners or additives, covered by the preceding groups, each of these compounds being essential
- C10M169/04—Mixtures of base-materials and additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1808—C8-(meth)acrylate, e.g. isooctyl (meth)acrylate or 2-ethylhexyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/10—Esters
- C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
- C08F222/102—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2201/00—Inorganic compounds or elements as ingredients in lubricant compositions
- C10M2201/10—Compounds containing silicon
- C10M2201/105—Silica
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2205/00—Organic macromolecular hydrocarbon compounds or fractions, whether or not modified by oxidation as ingredients in lubricant compositions
- C10M2205/14—Synthetic waxes, e.g. polythene waxes
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
- C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
- C10M2215/04—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to acyclic or cycloaliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
- C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
- C10M2215/06—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M2229/00—Organic macromolecular compounds containing atoms of elements not provided for in groups C10M2205/00, C10M2209/00, C10M2213/00, C10M2217/00, C10M2221/00 or C10M2225/00 as ingredients in lubricant compositions
- C10M2229/04—Siloxanes with specific structure
- C10M2229/05—Siloxanes with specific structure containing atoms other than silicon, hydrogen, oxygen or carbon
- C10M2229/051—Siloxanes with specific structure containing atoms other than silicon, hydrogen, oxygen or carbon containing halogen
- C10M2229/0515—Siloxanes with specific structure containing atoms other than silicon, hydrogen, oxygen or carbon containing halogen used as base material
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
- C10N2020/00—Specified physical or chemical properties or characteristics, i.e. function, of component of lubricating compositions
- C10N2020/01—Physico-chemical properties
- C10N2020/055—Particles related characteristics
- C10N2020/06—Particles of special shape or size
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
- C10N2030/00—Specified physical or chemical properties which is improved by the additive characterising the lubricating composition, e.g. multifunctional additives
- C10N2030/16—Antiseptic; (micro) biocidal or bactericidal
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
- C10N2040/00—Specified use or application for which the lubricating composition is intended
- C10N2040/50—Medical uses
Definitions
- the present invention relates to systems and methods for using antimicrobial coatings in various medical applications.
- One of the major challenges of modern medical treatment is control of infection and the spread of microbial organisms.
- Infusion therapy is one of the most common healthcare procedures. Hospitalized, home care, and other patients receive fluids, pharmaceuticals, and blood products via a vascular access device inserted into the patient's vascular system. Infusion therapy may be used to treat an infection, provide anesthesia or analgesia, provide nutritional support, treat cancerous growths, maintain blood pressure and heart rhythm, or for many other clinically significant uses.
- vascular access device may access a patient's peripheral or central vasculature. Additionally, the vascular access device may be indwelling for a short term (e.g., days), a moderate term (e.g., weeks), or a long term (e.g., months to years). The vascular access device may also be used for continuous infusion therapy or for intermittent therapy.
- a short term e.g., days
- a moderate term e.g., weeks
- long term e.g., months to years
- a common vascular access device is a plastic catheter that is inserted into a patient's vein. Generally, the length of such a catheter may vary from a few centimeters, for peripheral access, to many centimeters, for central access.
- the catheter may be inserted transcutaneously or may be surgically implanted beneath the patient's skin.
- the catheter, or any other vascular access device attached thereto, may have a single lumen or multiple lumens for infusion of many fluids simultaneously.
- the vascular access device commonly includes an adapter (e.g., a Luer adapter) to which other medical devices may be attached.
- an administration set may be attached to a vascular access device at one end while an intravenous (IV) bag is attached at the other.
- the administration set is a fluid conduit for the continuous infusion of fluids and pharmaceuticals.
- an IV access device is a vascular access device that attaches to another vascular access device, closes the vascular access device, and allows for intermittent infusion or injection of fluids and pharmaceuticals.
- An IV access device may include a housing and a septum for closing the system. The septum may be opened with a blunt cannula or a male Luer of a medical device.
- CVC central venous catheter
- BAI blood stream infection
- vascular access devices prevent complications, such as infection resulting in CRBSIs, by providing a septum that functions properly during attachment and/or access of the vascular access device by other medical devices. Septa that function properly will act, in part, as infection barriers between the internal and external environments of the vascular access device during attachment and/or access by other medical devices. By functioning properly as infection barriers, septa minimize CRBSIs and other complications.
- a vascular access device may serve as a nidus of infection, resulting in a disseminated BSI. This may be caused by failure to regularly flush the device, a non-sterile insertion technique, or by pathogens that enter the fluid flow path through either end of the path subsequent to catheter insertion.
- pathogens adhere to the vascular access device, colonize, and form a biofilm.
- biofilms are resistant to a variety of biocidal agents and provide a replenishing source for pathogens to enter a patient's bloodstream and cause a BSI.
- thermoplastic polyurethane solution As the carrier for an antimicrobial coating.
- the solvent is usually tetrahydrofuran (THF), dimethylformamide (DMF), or a blend of both. Because THF can be oxidized very quickly and tends to be very explosive, an expensive explosion-proof coating facility is necessary when THF is used as the solvent. Harsh solvents, such as THF and DMF, are also highly toxic and environmentally hazardous.
- the harsh solvents tend to attack most of the polymeric materials (i.e., polyurethane, silicone, polyisoprene, butyl rubber polycarbonate, polyvinyl chloride, PET, and acrylics) that are used to produce medical devices (e.g., vascular access devices). Therefore, medical devices that are made with these materials can become distorted and/or form micro-cracks on their surfaces.
- Another issue with coatings comprising harsh solvents is that such coatings generally require a relatively long period of time (e.g., about 24 hours) for the solvent to be completely heat evaporated.
- Still another issue with coatings comprising a harsh solvent is that such solvents are difficult to apply uniformly across the surface of a medical device. Accordingly, conventional technologies using harsh solvents have persistent problems with processing and performance.
- Silver salts and elemental silver are well known antimicrobial agents in both the medical surgical industry and general industries. They are usually incorporated into the polymeric bulk material or coated onto the surface of the medical devices by plasma, heat evaporation, electroplating, or by conventional solvent coating technologies. These technologies, however, are often very tedious, expensive, time consuming, and environmentally hazardous.
- the performance of silver coating medical devices is mediocre at best. For example, it can take up to 8 hours before the silver ion, ionized from the silver salts or silver element, can reach certain efficacy as an antimicrobial agent. As a result, substantial microbial activity can occur prior to the silver coating even becoming effective. Furthermore, the silver compound or silver element has an unpleasant color, from dark amber to black.
- the present invention has been developed in response to problems and needs in the art that have not yet been fully resolved by currently available systems and methods for applying antimicrobial coatings to medical devices.
- the described methods, systems, and compositions are developed to reduce complications (e.g., the occurrence of CRBSIs, damage to medical devices caused by harsh solvents, environmental damage caused by harsh solvents, etc.) by providing improved methods and systems for coating medical devices with an improved antimicrobial coating.
- the present invention includes coating a medical device with an antimicrobial coating.
- the described methods can be used to coat a medical device made from a variety of materials. In some preferred implementations, however, the described methods are used to coat medical devices that comprise one or more polymeric substrates, which include, but are not limited to, polycarbonate, polyurethane, polyvinyl chloride, acrylic, and combinations thereof.
- the described methods can be performed with one or more of a wide variety of coatings. Nevertheless, the preferred coating is selected from an ultraviolet light-(UV) curable, antimicrobial composition and an antimicrobial solution.
- the UV-curable composition can comprise any suitable ingredient.
- the UV-curable composition comprises a UV-curable material comprising one or more urethane- or polyester-type oligomers with at least one acrylate-type functional group, acrylate-type monomers, and photoinitiators. Additionally, in some implementations, the UV-curable composition further comprises one or more Theological modifiers and antimicrobial agents.
- the coating comprises the antimicrobial solution
- the solution can comprise any suitable ingredient.
- the solution comprises one or more solvents, coating resins, Theological modifiers, and antimicrobial agents.
- the described methods generally include providing a medical device, dispensing an antimicrobial coating onto a surface of the device, flushing excess coating from the device, and curing the coating onto the device.
- the methods can be modified in any suitable manner.
- the methods include masking a portion of the device to prevent the coating from being deposited on the portion of the medical device that is covered by the masking.
- the coating can be dispensed onto a surface of the device in any suitable manner.
- a machine injects a calculated amount of the coating into the device.
- excess coating can be removed from the device in any suitable manner.
- the excess coating can be removed by blowing the excess coating from the device with an inert gas, spinning the medical device in a centrifuge, by wiping the device with a material, through gravity, etc.
- nitrogen gas is used to blow the excess coating from the medical device.
- the coating can be cured in any suitable manner.
- the UV-curable composition can be rapidly cured through exposure to UV light.
- the composition can be cured within seconds or minutes, depending on the formulation and curing conditions.
- the antimicrobial solution can be cured relatively quickly by exposure to heat (e.g., infrared heat). Indeed, under certain circumstances, the solution can be heat-cured at about 100° Celsius (C.) in about 5 minutes or less.
- FIG. 1 illustrates a block diagram of a representative embodiment of a method for coating a medical device with an antimicrobial coating
- FIG. 2 illustrates a block diagram of a representative embodiment of the method for coating a medical device with an antimicrobial coating
- FIG. 3 illustrates a perspective view of a representative embodiment of an IV access device
- FIG. 4A illustrates a perspective view of a representative embodiment of a system for applying an antimicrobial coating to a medical device
- FIG. 4B illustrates a perspective view of a representative pallet for holding a medical device during operation of the system shown in FIG. 4A .
- the described invention relates to methods and compositions for coating one or more surfaces of a medical device with an antimicrobial coating. Once the antimicrobial coating is cured onto the medical device, an antimicrobial agent in the coating can gradually diffuse out of the coating when the coating is softened by IV fluids or other types of fluids. Accordingly, microbes that come into contact with the coated surface of the medical device can be killed and the medical device may remain sanitary for a prolonged period of time.
- FIG. 1 illustrates a representative embodiment of the described coating methods.
- the method 10 for coating a medical device with an antimicrobial coating generally comprises providing a medical device 12 , dispensing an antimicrobial coating onto the device 14 , flushing excess coating from the device 16 , and curing the coating to the device.
- the following disclosure provides a more detailed disclosure of medical devices and antimicrobial coatings that can be used with the coating method, the various stages of method, and systems for performing the method.
- the methods can be used with any suitable medical device, including, but not limited to, an IV access device, medical tubing, a catheter assembly, and any other viable medical-grade instrument that contacts fluids flowing into or out of a patient.
- the medical device can comprise any material that is suitable for use with the described methods.
- the medical device comprises one or more polymeric substrates.
- the medical device can comprise one or more polycarbonates, polyurethanes, polyvinyl chlorides, silicones, PET plastics, styrene-butadiene rubbers, acrylics, and combinations thereof.
- the antimicrobial coating can comprise any suitable antimicrobial composition that is suitable for use on the medical device. Nevertheless, in preferred embodiments, the antimicrobial coating is selected from a UV-curable, antimicrobial composition and an antimicrobial solution. To provide a better understanding of the UV-curable composition and the antimicrobial solution, each is discussed below in more detail.
- the antimicrobial coating comprises the UV-curable, antimicrobial composition.
- the UV-curable composition may comprise any suitable ingredient.
- the UV-curable coating comprises materials (referred to herein the UV-curable material) that are capable of forming a UV-curable polymer composition. While the UV-curable material may comprise any suitable ingredient, in some preferred embodiments, the UV-curable material comprises one or more oligomers, monomers, and photoinitiators. In addition to the UV-curable material, the UV-curable composition further comprises an effective antimicrobial agent.
- the UV-curable material will comprise 100 parts by weight. Additionally, the ingredients added to the UV-curable material to form the UV-curable composition will be defined in parts by weight added to 100 parts by weight of the UV-curable material.
- the UV-curable material may comprise any oligomer that is compatible with the other components of the UV-curable composition and that is usable within the scope of the present invention. Nevertheless, the oligomer is generally selected from one or more acrylated aliphatic urethanes, acrylated aromatic urethanes, acrylated polyesters, unsaturated polyesters, acrylated polyethers, acrylated acrylics, and the like, or combinations thereof. Indeed, in some embodiments, the UV-curable coating comprises a urethane- or polyester-type acrylate, such as 7104 , 7101 , 7124 -K, 7105-5K from Electronic Materials Inc.
- the oligomer comprises an acrylated functional group
- the functional group is preferably selected from a mono-functional, di-functional, tri-functional, tetra-functional, penta-functional, and hexa-functional acrylate.
- the oligomer may account for any suitable portion of the UV-curable material. Typically, however, the oligomer will comprise from about 10% to about 90% of the UV-curable material. In some preferred embodiments, the oligomer comprises from about 20% to about 80% of the UV-curable material. In certain other embodiments, however, the oligomer comprises from about 30% to about 70% of the UV-curable material.
- the monomer in the UV-curable material can be selected from any monomer that is compatible with the other components of the UV-curable composition and that is usable within the scope of the invention, the monomer is preferably selected from 2-ethyl hexyl acrylate, isooctyl acrylate, isobomylacrylate, 1,6-hexanediol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, pentaerythritol tetra acrylate, penta erythritol tri acrylate, dimethoxy phenyl acetophenone hexyl methyl acrylate, 1,6 hexanidiol methacrylate, and the like, or combinations of these compounds.
- the monomer comprises from about 5% to about 90% of the UV-curable material. In other embodiments, however, the monomer comprises from about 10% to about 75% of the UV-curable material. In still other embodiments, the monomer comprises from about 20% to about 60% of the UV-curable material.
- the photoinitiator can comprise any photoinitiator that is compatible with the other components of the UV-curable composition (i.e., the UV-curable material) and that is usable within the scope of the invention.
- the photoinitiator is selected from either a single molecule cleavage type photoinitiator, such as one or more benzoin ethers, acetophenones, benzoyl oximes, and acyl phosphine oxides; or a hydrogen abstraction type of photoinitiator, such as Michler's ketone, thioxanthone, anthroguionone, benzophenone, methyl diethanol amine, and 2-N-butoxyethyl-4-(dimethylamino) benzoate.
- a single molecule cleavage type photoinitiator such as one or more benzoin ethers, acetophenones, benzoyl oximes, and acyl phosphine oxides
- the photoinitiator typically comprises from about 0.5% to about 10% of the UV-curable material. Indeed, in some embodiments, the photoinitiator comprises from about 1% to about 8.5% of the UV-curable material. In still other embodiments, the photoinitiator comprises from about 2% to about 7% of the UV-curable material.
- the antimicrobial agent can comprise any antimicrobial agent that is compatible with the other components of the UV-curable composition and that is usable within the scope of the invention. Additionally, in some embodiments, the antimicrobial agent comprises an agent that either dissolves in the UV-curable composition or can be uniformly distributed therein. Accordingly, in such embodiments, sufficient antimicrobial agent can migrate within the UV-curable composition to contact the location of microbial activity. In any event, it is preferred that the antimicrobial agent not react chemically with the other components of the UV-curable composition.
- Some examples of antimicrobial agents that are suitable for use with the UV-curable composition include one or more aldehydes, anilides, biguanides, silver, silver compound, bis-phenols, and quaternary ammonium compounds.
- the antimicrobial agent is generally present in the UV-curable composition in the amount of from about 0.5 to about 50 parts, by weight, in comparison to 100 parts by weight of the UV-curable material. In other embodiments, the antimicrobial agent is present in the UV-curable composition in the amount of from about 0.5 to about 30 parts, by weight, in comparison to 100 parts of the UV-curable material. In further embodiments of the UV-curable composition, the antimicrobial agent is present in the amount of from about 0.5 to about 20 parts, by weight, in comparison to 100 parts of the UV-curable material.
- the UV-curable composition can comprise any other suitable component.
- the UV-curable composition also includes a Theological modifier to improve the composition's flow characteristics and to help components be uniformly distributed throughout the composition.
- the Theological modifier is preferably selected from organic clay, castor wax, polyamide wax, polyurethane, and fumed silica.
- the Theological modifier generally comprises from about 0.1 to about 30 parts, by weight, added to 100 parts, by weight, of the UV-curable material (i.e. the UV-curable material is 100 weight units, while the Theological modifier comprises from about 0.1 to about 30 parts of additional weight that is added to the 100 parts of the UV-curable material).
- the Theological modifier comprises from 0.1 to about 20 parts by weight compared to 100 parts by weight of the UV-curable material. In certain further embodiments, the rheological modifier comprises from about 0.2 to about 10 parts by weight compared to 100 parts by weight of the UV-curable material.
- the UV-curable composition may also have any other suitable characteristic.
- the UV-curable composition has a viscosity that is less than about 10,000 centipoises (cps). In other embodiments, the viscosity of the UV-curable composition is below about 5,000 cps. In some presently preferred embodiments, the UV-curable composition has a viscosity that is between about 20 and about 1,000 cps.
- UV-curable composition has been described above with specificity, a more detailed description of the UV-curable composition is found in U.S. patent application Ser. No. 12/397,760, filed Mar. 4, 2009, and entitled “Antimicrobial Compositions;” the entire disclosure of which is hereby incorporated by reference.
- the antimicrobial coating comprises an antimicrobial solution
- the solution may comprise any suitable ingredient.
- the antibacterial solution comprises an acrylate polymer or copolymer, a solvent, and an antimicrobial agent. To provide a better understanding of the antimicrobial solution, each of its aforementioned ingredients is described below in more detail.
- the acrylate polymer or copolymer can comprise any acrylate polymer and/or copolymer that is compatible with the other components of the antimicrobial solution and that is usable within the scope of the invention.
- the acrylate-type polymer, copolymer, or polymer resin is insoluble in water while being soluble in one or more of the solvents that are discussed hereinafter.
- the acrylate polymer or copolymer is generally selected from one or more alkyl acrylates, alkyl methacryloates, alkyl hydroxyl (meth) acrylates, and alkyl methoxycinnamate acrylates.
- the acrylate can be alkyl acrylate, alkyl hydroxyl (meth) acrylate, or alkyl methacrylate.
- the alkyl group can have a carbon number from 0 to 22, wherein 0 means hydrogen, 1 means a methyl group, 2 means an ethyl group, 3 means a propyl group, etc.), but preferably a number from 0 to 6, and more preferably from 0 to 3.
- the solvent in the antimicrobial solution can comprise any solvent that is compatible with the other components of the antimicrobial solution and that allows the solution to function as intended.
- the solvent may comprise one or more of a variety of solvents that are capable of dissolving the aforementioned acrylate polymer or copolymer.
- suitable solvents include one or more low molecular weight alcohols, low molecular weight alkanes, simple ketones, and combinations thereof.
- suitable low molecular weight alcohols comprise alcohols having from 1 to 6 carbons (e.g., methanol, ethanol, propanol, isopropanol, and butanol). Because methanol evaporates relatively quickly, however, methanol may not be preferred in all embodiments.
- the solvent comprises ethanol or isopropanol.
- suitable low molecular weight alkanes comprise alkanes having from 5 to 7 carbons (e.g., pentane, hexane, heptane, and isomers thereof).
- the solvent comprises hexane and/or heptane.
- an example of a suitable simple ketone is acetone. It should be noted, however, that in some embodiments that comprises acetone, the solvent preferably also comprises another solvent, such as an alcohol or an alkane.
- the solvent may comprise any suitable amount of the antimicrobial solution, in some embodiments, the solvent comprises less than about 67% of the dry weight of the antimicrobial solution. For instance, where the polymer accounts for about 60% ⁇ 10% of the antimicrobial solution, the solvent can account for less than about 40% ⁇ 10% of the solution. In other embodiments, however, the solvent comprises less than about 50% of the dry weight of the composition. In still other embodiments, the solvent comprises less than about 40% of the dry weight of the composition.
- the antimicrobial agent in the antimicrobial solution can comprise any antimicrobial agent that is compatible with the other components of the solution and that allows the solution to function as intended.
- the antimicrobial agent for the antimicrobial solution is generally selected from one or more aldehydes, anilides, biguanides, silver, silver compounds, bis-pheonols, and quaternary ammonium compounds.
- the antimicrobial agent is preferably selected from cetyl pyridium chloride, cetrimide, benzalkonium chloride, alexidine, chlorexidine diacetate, and o-phthalaldehyde.
- the antimicrobial agent may comprise any suitable amount of the antimicrobial solution, in some embodiments, the antimicrobial agent comprises less than about 50% of the dry weight of the solution. In other embodiments, the antimicrobial comprises less than about 30% of the dry weight of the antimicrobial solution. In still other embodiments, the antimicrobial agent comprises about 0.5% and about 20% of the dry weight of the antimicrobial solution.
- the antimicrobial solution may comprise any other suitable ingredient.
- the antimicrobial solution comprises a Theological modifier that is generally selected from organic clay, castor wax, polyamide wax, polyurethane, and fumed silica.
- the Theological modifier is generally present in an amount of from about 0.2% to about 30% of the dry weight of the antimicrobial solution. That is, the weight of the composition once the solvent has evaporated.
- the rheological modifier is present in the amount of from about 0.2% to about 20% of the dry weight of the antimicrobial solution.
- the rheological modifier is present in an amount of from about 0.2% to about 10% of the dry weight of the antimicrobial solution.
- FIG. 2 illustrates one presently preferred embodiment of the described method for coating a medical device. Specifically, FIG. 2 shows an example in which the method 11 begins at 12 by providing a medical device.
- FIG. 2 shows the method 10 optionally includes masking one or more desired portions of the medical device to prevent the antimicrobial coating from contacting the masked portion(s).
- FIG. 3 shows that where the medical device comprises a portion of an IV access device 100 (e.g., BECTON DICKINSON's Q-SYTE® IV access device) having a Luer component 102 , the Luer component 102 can be inserted into a medical-grade tube 104 so that the external surface of the Luer 102 is prevented from being coated with the antimicrobial coating.
- an IV access device 100 e.g., BECTON DICKINSON's Q-SYTE® IV access device
- box 14 shows that the method 10 continues by dispensing the antimicrobial coating (e.g., the UV-curable composition or the antimicrobial solution) onto the medical device.
- the antimicrobial coating e.g., the UV-curable composition or the antimicrobial solution
- Any suitable amount of the antimicrobial coating can be dispensed onto the desired surface(s) of the medical device.
- the medical device comprises the IV access device of FIG. 3
- between about 0.01 and about 0.05 grams of the antimicrobial coating can be dispensed into the device's inner lumen 106 .
- between 0.02 and about 0.04 grams of antimicrobial coating are dispensed into the device's inner lumen.
- box 16 of FIG. 2 shows that any excess coating on the device is flushed or otherwise removed from the medical device.
- the antimicrobial coating can be caused to have a uniform thickness across the coated surface.
- the excess coating can be removed in any suitable manner, including by blowing an inert gas across the coated surface of the medical device, spinning the medical device in a centrifuge, by allowing excess material to drip from the device due to the pull of gravity, etc.
- a pressured inert gas such as nitrogen, helium, or argon, is blown across the coated surface.
- an insert gas such as nitrogen
- an air pressure of between about 5 and about 25 pounds per square inch (psi) (e.g., 10 psi ⁇ 5 psi) is preferably blown past the coated surface.
- box 17 of FIG. 2 shows that the excess antimicrobial coating that is flushed from the medical device is optionally collected and recycled. In other words, the excess antimicrobial coating can be collected and be used to coat another medical device.
- boxes 20 and 22 show that the coating left on the device is cured. While the antimicrobial coating can be cured in any suitable manner, box 20 shows that in some embodiments where the antimicrobial coating comprises the UV-curable composition, the UV-curable composition is cured by being exposed to UV light. In such embodiments, the UV-curable composition can be exposed to any suitable wavelength of UV light. In one example, the UV-curable composition is exposed to UV light with a wavelength of between about 320 to about 500 nm. In another example, the UV-curable composition is cross-linked by being exposed to light with a wavelength of between about 350 and about 450 nm.
- the UV-curable composition can be exposed to the UV light for any amount of time that allows the UV-curable composition to dry and be cured to the medical device. Indeed, in one example, the UV-curable composition is cured after less than about 1 minute of exposure to the UV light. In another example, the UV-curable coating is cured after less than about 30 seconds of exposure to the UV light. In still another example, the UV-curable coating is cured after less than about 10 seconds of exposure to the UV light. In a final example, the UV-curable coating is cured after less than about 4 seconds of exposure to the UV light.
- FIG. 2 shows that in some embodiments where the antimicrobial coating comprises the antimicrobial solution, the solution is cured through exposure to heat from a heat source (e.g., an infrared heater, a convectional heater, a conventional heater, etc.).
- a heat source e.g., an infrared heater, a convectional heater, a conventional heater, etc.
- the antimicrobial solution coating the device can be cured at any suitable temperature.
- the solution is cured at a temperature of less than about 120° C.
- the antimicrobial solution is cured at a temperature of less than about 100° C.
- the antimicrobial solution is cured at a temperature of less than about 60° C.
- the antimicrobial solution can be cured in any suitable amount of time, under certain conditions, the solution is cured after less than about 10 minutes of exposure to a temperature of less than about 60° C. Similarly, under certain conditions, the antimicrobial solution is cured after less than about 5 minutes of exposure to a temperature of less than about 100° C.
- box 24 of FIG. 2 shows that any masking material is optionally removed from the medical device.
- the medical device can be used and the antimicrobial coating can be effective almost immediately after being exposed to a fluid (e.g., an IV fluid).
- a fluid e.g., an IV fluid
- FIG. 4A illustrates a representative embodiment in which the medical device coating system 200 comprises a medical device pallet 202 , a top slide 204 having coating-dispending heads 206 and gas-dispensing heads 208 , coating valves 210 , gas valves 212 , a gas reservoir 214 , excess funnels 216 , and a pressurized coating reservoir 218 .
- FIG. 4B shows that one or more medical devices, such as the IV access device 100 , can be placed on the medical device pallet 202 so that an opening 108 to the inner lumen 106 of the device 100 is facing towards a coating-dispensing head 206 (shown in FIG. 4A ).
- the pallet may secure the medical device in a desired orientation, in any suitable manner.
- FIG. 4B shows an embodiment in which the IV access device 100 is secured to the pallet 202 when a lip 110 on the access device 100 is slid into a groove 220 on the pallet 202 .
- FIG. 4A shows that the pallet 202 is placed beneath the top slide 204 .
- the top slide 204 may move with respect to the pallet 202 so that a coating dispensing head 206 is disposed above the opening of each device (not shown in FIG. 4A ).
- the coating valves 210 are opened to allow a predetermined amount (e.g., between about 0.01 and about 0.05 g) of antimicrobial coating to be squirt from the pressurized coating reservoir 218 , through the coating-dispensing heads 206 , and onto the medical device. While this dispensing process can take any suitable amount of time, in some instances, the dispensing process takes as little as 4 seconds or less (e.g., about 2 seconds+1 second).
- the top slide 204 moves in the direction of arrow 222 so that a gas-dispensing head 208 is disposed above the coated surface of each medical device. Once the gas-dispensing heads are properly aligned, the top slide 204 moves in the direction of arrow 224 so that the gas-dispensing heads 208 form a seal against the medical device's opening (not shown in FIG. 4A ). Once a seal is formed, the gas valves 212 open to allow a controlled amount of the inert gas, at a controlled pressure, to flush any excess coating from the medical device. This excess coating is then collected in the excess funnels 216 , which direct the excess coating back to the pressurized coating reservoir 218 for future use.
- the pallet 202 can be removed from beneath the top slide 204 and be placed in a curing chamber (not shown), such as a UV-light chamber or a heated chamber-depending on composition of the antimicrobial coating.
- a curing chamber such as a UV-light chamber or a heated chamber-depending on composition of the antimicrobial coating.
- the medical devices are removed from the pallet and new batch of uncoated medical devices can be placed in the pallet so that the process can be repeated.
- the described system can be modified in any suitable manner.
- FIG. 4A shows an embodiment in which the system 200 is configured to coat 4 medical devices simultaneously
- the system can modified to simultaneously coat any suitable number of medical devices.
- the system can be modified to coat 1 , 2 , 3 , 5 , 6 , 7 , 8 , or more medical devices, simultaneously.
- the antimicrobial coating and the inert gas may be dispensed to a medical device through single head so as to speed the time between the dispensing and flushing portions of the method.
- the pallet, the gas dispensing head, or some other component in proximity to the medical devices can comprise a UV light source. In such embodiments, the system can cure the medical devices without requiring the pallet to be removed from a location beneath the top slide.
- the described methods, apparatus, and compositions have several beneficial characteristics.
- the described methods allow a medical device to be coated with an antimicrobial coating (e.g., the UV-curable composition) in a relatively short period of time. For instance, instead of taking several hours (e.g., 24) to cure a harsh solvent (e.g., THF or DMF) onto a medical device, the UV-curable coating and the antimicrobial solution can be cured onto a medical device in a few second or minutes, respectively.
- the antimicrobial coating comprises the UV-curable composition
- the composition can be dispensed, flushed, and cured within about 30 seconds.
- the UV-curable composition can be dispensed, flushed, and cured within about 10 seconds.
- the antimicrobial coating comprises the antimicrobial solution
- the solution is dispensed, flushed, and cured within about 10 minutes. In some presently preferred embodiments, however, the antimicrobial solution is dispensed, flushed, and cured in less than about 5 minutes.
- the methods can allow the antimicrobial coating to be applied to the medical device with a substantially uniform coating thickness.
- the described methods may use less antimicrobial coating, overall, than certain conventional coating techniques.
- the described UV-curable and antimicrobial solutions provide several advantages over certain known antimicrobial coatings.
- the UV-curable and antimicrobial solutions can be less toxic, less expensive, more environmentally friendly, cause less deformation or cracking to a medical device, be more aesthetically pleasing, and require less-expensive equipment than do several competing antimicrobial coatings (e.g., THF and DMF).
Abstract
Description
- This application claims priority to U.S. Provisional Patent Application No. 61/118,988, filed Dec. 1, 2008, entitled “Antimicrobial Compositions and Methods for Medical Product Use;” the entire disclosure of which is incorporated herein by this reference.
- The present invention relates to systems and methods for using antimicrobial coatings in various medical applications. One of the major challenges of modern medical treatment is control of infection and the spread of microbial organisms.
- One area where this challenge is constantly presented is in infusion therapies of various types. Infusion therapy is one of the most common healthcare procedures. Hospitalized, home care, and other patients receive fluids, pharmaceuticals, and blood products via a vascular access device inserted into the patient's vascular system. Infusion therapy may be used to treat an infection, provide anesthesia or analgesia, provide nutritional support, treat cancerous growths, maintain blood pressure and heart rhythm, or for many other clinically significant uses.
- Infusion therapy is facilitated by a vascular access device. The vascular access device may access a patient's peripheral or central vasculature. Additionally, the vascular access device may be indwelling for a short term (e.g., days), a moderate term (e.g., weeks), or a long term (e.g., months to years). The vascular access device may also be used for continuous infusion therapy or for intermittent therapy.
- A common vascular access device is a plastic catheter that is inserted into a patient's vein. Generally, the length of such a catheter may vary from a few centimeters, for peripheral access, to many centimeters, for central access. The catheter may be inserted transcutaneously or may be surgically implanted beneath the patient's skin. The catheter, or any other vascular access device attached thereto, may have a single lumen or multiple lumens for infusion of many fluids simultaneously.
- The vascular access device commonly includes an adapter (e.g., a Luer adapter) to which other medical devices may be attached. For example, an administration set may be attached to a vascular access device at one end while an intravenous (IV) bag is attached at the other. The administration set is a fluid conduit for the continuous infusion of fluids and pharmaceuticals. Commonly, an IV access device is a vascular access device that attaches to another vascular access device, closes the vascular access device, and allows for intermittent infusion or injection of fluids and pharmaceuticals. An IV access device may include a housing and a septum for closing the system. The septum may be opened with a blunt cannula or a male Luer of a medical device.
- When the septum of a vascular access device fails to operate properly or has inadequate design features, certain complications may occur. Complications associated with infusion therapy may cause significant morbidity and even mortality. One significant complication is catheter related blood stream infection (CRBSI). An estimate of 250,000-400,000 cases of central venous catheter (CVC) associated blood stream infections (BSIs) occur annually in US hospitals.
- Current vascular access devices prevent complications, such as infection resulting in CRBSIs, by providing a septum that functions properly during attachment and/or access of the vascular access device by other medical devices. Septa that function properly will act, in part, as infection barriers between the internal and external environments of the vascular access device during attachment and/or access by other medical devices. By functioning properly as infection barriers, septa minimize CRBSIs and other complications.
- In some cases, a vascular access device may serve as a nidus of infection, resulting in a disseminated BSI. This may be caused by failure to regularly flush the device, a non-sterile insertion technique, or by pathogens that enter the fluid flow path through either end of the path subsequent to catheter insertion. When a vascular access device is contaminated, pathogens adhere to the vascular access device, colonize, and form a biofilm. Many such biofilms are resistant to a variety of biocidal agents and provide a replenishing source for pathogens to enter a patient's bloodstream and cause a BSI.
- Over the past few decades, it has been a common practice to use a thermoplastic polyurethane solution as the carrier for an antimicrobial coating. The solvent is usually tetrahydrofuran (THF), dimethylformamide (DMF), or a blend of both. Because THF can be oxidized very quickly and tends to be very explosive, an expensive explosion-proof coating facility is necessary when THF is used as the solvent. Harsh solvents, such as THF and DMF, are also highly toxic and environmentally hazardous. Additionally, the harsh solvents tend to attack most of the polymeric materials (i.e., polyurethane, silicone, polyisoprene, butyl rubber polycarbonate, polyvinyl chloride, PET, and acrylics) that are used to produce medical devices (e.g., vascular access devices). Therefore, medical devices that are made with these materials can become distorted and/or form micro-cracks on their surfaces. Another issue with coatings comprising harsh solvents is that such coatings generally require a relatively long period of time (e.g., about 24 hours) for the solvent to be completely heat evaporated. Still another issue with coatings comprising a harsh solvent is that such solvents are difficult to apply uniformly across the surface of a medical device. Accordingly, conventional technologies using harsh solvents have persistent problems with processing and performance.
- Another conventional method for providing medical devices with antimicrobial characteristics involves the use of silver salts and elemental silver. Silver salts and elemental silver are well known antimicrobial agents in both the medical surgical industry and general industries. They are usually incorporated into the polymeric bulk material or coated onto the surface of the medical devices by plasma, heat evaporation, electroplating, or by conventional solvent coating technologies. These technologies, however, are often very tedious, expensive, time consuming, and environmentally hazardous.
- In addition, the performance of silver coating medical devices is mediocre at best. For example, it can take up to 8 hours before the silver ion, ionized from the silver salts or silver element, can reach certain efficacy as an antimicrobial agent. As a result, substantial microbial activity can occur prior to the silver coating even becoming effective. Furthermore, the silver compound or silver element has an unpleasant color, from dark amber to black.
- Accordingly, there is a need in the art for improved coatings for providing antimicrobial capability to medical devices of various types, and particularly to devices related to infusion therapy. There is also a need for improved methods of applying such antimicrobial coatings to medical devices.
- The present invention has been developed in response to problems and needs in the art that have not yet been fully resolved by currently available systems and methods for applying antimicrobial coatings to medical devices. Thus, the described methods, systems, and compositions are developed to reduce complications (e.g., the occurrence of CRBSIs, damage to medical devices caused by harsh solvents, environmental damage caused by harsh solvents, etc.) by providing improved methods and systems for coating medical devices with an improved antimicrobial coating.
- Generally, the present invention includes coating a medical device with an antimicrobial coating. The described methods can be used to coat a medical device made from a variety of materials. In some preferred implementations, however, the described methods are used to coat medical devices that comprise one or more polymeric substrates, which include, but are not limited to, polycarbonate, polyurethane, polyvinyl chloride, acrylic, and combinations thereof.
- The described methods can be performed with one or more of a wide variety of coatings. Nevertheless, the preferred coating is selected from an ultraviolet light-(UV) curable, antimicrobial composition and an antimicrobial solution.
- Where the coating comprises the UV-curable, antimicrobial composition, the UV-curable composition can comprise any suitable ingredient. In some implementations, the UV-curable composition comprises a UV-curable material comprising one or more urethane- or polyester-type oligomers with at least one acrylate-type functional group, acrylate-type monomers, and photoinitiators. Additionally, in some implementations, the UV-curable composition further comprises one or more Theological modifiers and antimicrobial agents.
- Where the coating comprises the antimicrobial solution, the solution can comprise any suitable ingredient. Indeed, in some implementations, the solution comprises one or more solvents, coating resins, Theological modifiers, and antimicrobial agents.
- The described methods generally include providing a medical device, dispensing an antimicrobial coating onto a surface of the device, flushing excess coating from the device, and curing the coating onto the device. Of course, the methods can be modified in any suitable manner. In one example of a modification, the methods include masking a portion of the device to prevent the coating from being deposited on the portion of the medical device that is covered by the masking.
- In the described methods, the coating can be dispensed onto a surface of the device in any suitable manner. In one example, a machine injects a calculated amount of the coating into the device.
- After the antimicrobial coating has been applied to the medical device, excess coating, if any, can be removed from the device in any suitable manner. For example, the excess coating can be removed by blowing the excess coating from the device with an inert gas, spinning the medical device in a centrifuge, by wiping the device with a material, through gravity, etc. In some presently preferred implementations, however, nitrogen gas is used to blow the excess coating from the medical device.
- With the excess coating removed from the medical device, the coating can be cured in any suitable manner. For example, the UV-curable composition can be rapidly cured through exposure to UV light. For instance, after the UV-curable composition is applied to the medical device, the composition can be cured within seconds or minutes, depending on the formulation and curing conditions. In another example, the antimicrobial solution can be cured relatively quickly by exposure to heat (e.g., infrared heat). Indeed, under certain circumstances, the solution can be heat-cured at about 100° Celsius (C.) in about 5 minutes or less.
- While the methods of the present invention have proven to be particularly useful in the area of coating IV access devices, those skilled in the art will appreciate that the described methods can be used for a variety of different applications in a variety of different areas of manufacture that include coating an object with an antimicrobial coating.
- These and other features and advantages of the present invention will be set forth or will become more fully apparent in the description that follows and in the appended claims. The features and advantages may be realized and obtained by means of the instruments and combinations particularly pointed out in the appended claims. Furthermore, the features and advantages of the intention may be learned by the practice of the invention or will be obvious from the description, as set forth hereinafter.
- In order that the manner in which the above-recited and other features and advantages of the invention are obtained and will be readily understood, a more particular description of the invention briefly described above will be rendered by reference to specific embodiments thereof, which are illustrated in the appended drawings. Understanding that these drawings depict only typical embodiments of the invention and are not, therefore, to be considered to be limiting of its scope, the invention will be described and explained with additional specificity and detail through the use of the accompanying drawings in which:
-
FIG. 1 illustrates a block diagram of a representative embodiment of a method for coating a medical device with an antimicrobial coating; -
FIG. 2 illustrates a block diagram of a representative embodiment of the method for coating a medical device with an antimicrobial coating; -
FIG. 3 illustrates a perspective view of a representative embodiment of an IV access device; -
FIG. 4A illustrates a perspective view of a representative embodiment of a system for applying an antimicrobial coating to a medical device; and -
FIG. 4B illustrates a perspective view of a representative pallet for holding a medical device during operation of the system shown inFIG. 4A . - The described invention relates to methods and compositions for coating one or more surfaces of a medical device with an antimicrobial coating. Once the antimicrobial coating is cured onto the medical device, an antimicrobial agent in the coating can gradually diffuse out of the coating when the coating is softened by IV fluids or other types of fluids. Accordingly, microbes that come into contact with the coated surface of the medical device can be killed and the medical device may remain sanitary for a prolonged period of time.
-
FIG. 1 illustrates a representative embodiment of the described coating methods. Specifically,FIG. 1 shows that themethod 10 for coating a medical device with an antimicrobial coating generally comprises providing amedical device 12, dispensing an antimicrobial coating onto thedevice 14, flushing excess coating from thedevice 16, and curing the coating to the device. In order to provide a better understanding of the described coating method, the following disclosure provides a more detailed disclosure of medical devices and antimicrobial coatings that can be used with the coating method, the various stages of method, and systems for performing the method. - With respect to the types of medical devices that can be used with the described coating methods, the methods can be used with any suitable medical device, including, but not limited to, an IV access device, medical tubing, a catheter assembly, and any other viable medical-grade instrument that contacts fluids flowing into or out of a patient.
- The medical device can comprise any material that is suitable for use with the described methods. In some typical embodiments, however, the medical device comprises one or more polymeric substrates. For instance, the medical device can comprise one or more polycarbonates, polyurethanes, polyvinyl chlorides, silicones, PET plastics, styrene-butadiene rubbers, acrylics, and combinations thereof.
- The antimicrobial coating can comprise any suitable antimicrobial composition that is suitable for use on the medical device. Nevertheless, in preferred embodiments, the antimicrobial coating is selected from a UV-curable, antimicrobial composition and an antimicrobial solution. To provide a better understanding of the UV-curable composition and the antimicrobial solution, each is discussed below in more detail.
- In some currently preferred embodiments, the antimicrobial coating comprises the UV-curable, antimicrobial composition. In such embodiments, the UV-curable composition may comprise any suitable ingredient. In one aspect of the invention, the UV-curable coating comprises materials (referred to herein the UV-curable material) that are capable of forming a UV-curable polymer composition. While the UV-curable material may comprise any suitable ingredient, in some preferred embodiments, the UV-curable material comprises one or more oligomers, monomers, and photoinitiators. In addition to the UV-curable material, the UV-curable composition further comprises an effective antimicrobial agent. The various ingredients that are added together to form the UV-curable composition are described below. In the following discussion, the UV-curable material will comprise 100 parts by weight. Additionally, the ingredients added to the UV-curable material to form the UV-curable composition will be defined in parts by weight added to 100 parts by weight of the UV-curable material.
- The UV-curable material may comprise any oligomer that is compatible with the other components of the UV-curable composition and that is usable within the scope of the present invention. Nevertheless, the oligomer is generally selected from one or more acrylated aliphatic urethanes, acrylated aromatic urethanes, acrylated polyesters, unsaturated polyesters, acrylated polyethers, acrylated acrylics, and the like, or combinations thereof. Indeed, in some embodiments, the UV-curable coating comprises a urethane- or polyester-type acrylate, such as 7104, 7101, 7124-K, 7105-5K from Electronic Materials Inc. (EMI) (EM Breckenridge, Co.), 1168-M, 1-20781 from Dymax Corporation (Torrington, Conn.), or UV 630 from Permabond Engineering Adhesives (Somerset, N.J.). Where the oligomer comprises an acrylated functional group, the functional group is preferably selected from a mono-functional, di-functional, tri-functional, tetra-functional, penta-functional, and hexa-functional acrylate.
- The oligomer may account for any suitable portion of the UV-curable material. Typically, however, the oligomer will comprise from about 10% to about 90% of the UV-curable material. In some preferred embodiments, the oligomer comprises from about 20% to about 80% of the UV-curable material. In certain other embodiments, however, the oligomer comprises from about 30% to about 70% of the UV-curable material.
- While the monomer in the UV-curable material can be selected from any monomer that is compatible with the other components of the UV-curable composition and that is usable within the scope of the invention, the monomer is preferably selected from 2-ethyl hexyl acrylate, isooctyl acrylate, isobomylacrylate, 1,6-hexanediol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, pentaerythritol tetra acrylate, penta erythritol tri acrylate, dimethoxy phenyl acetophenone hexyl methyl acrylate, 1,6 hexanidiol methacrylate, and the like, or combinations of these compounds.
- In typical embodiments, the monomer comprises from about 5% to about 90% of the UV-curable material. In other embodiments, however, the monomer comprises from about 10% to about 75% of the UV-curable material. In still other embodiments, the monomer comprises from about 20% to about 60% of the UV-curable material.
- The photoinitiator can comprise any photoinitiator that is compatible with the other components of the UV-curable composition (i.e., the UV-curable material) and that is usable within the scope of the invention. Generally, the photoinitiator is selected from either a single molecule cleavage type photoinitiator, such as one or more benzoin ethers, acetophenones, benzoyl oximes, and acyl phosphine oxides; or a hydrogen abstraction type of photoinitiator, such as Michler's ketone, thioxanthone, anthroguionone, benzophenone, methyl diethanol amine, and 2-N-butoxyethyl-4-(dimethylamino) benzoate.
- The photoinitiator typically comprises from about 0.5% to about 10% of the UV-curable material. Indeed, in some embodiments, the photoinitiator comprises from about 1% to about 8.5% of the UV-curable material. In still other embodiments, the photoinitiator comprises from about 2% to about 7% of the UV-curable material.
- The antimicrobial agent can comprise any antimicrobial agent that is compatible with the other components of the UV-curable composition and that is usable within the scope of the invention. Additionally, in some embodiments, the antimicrobial agent comprises an agent that either dissolves in the UV-curable composition or can be uniformly distributed therein. Accordingly, in such embodiments, sufficient antimicrobial agent can migrate within the UV-curable composition to contact the location of microbial activity. In any event, it is preferred that the antimicrobial agent not react chemically with the other components of the UV-curable composition. Some examples of antimicrobial agents that are suitable for use with the UV-curable composition include one or more aldehydes, anilides, biguanides, silver, silver compound, bis-phenols, and quaternary ammonium compounds.
- The antimicrobial agent is generally present in the UV-curable composition in the amount of from about 0.5 to about 50 parts, by weight, in comparison to 100 parts by weight of the UV-curable material. In other embodiments, the antimicrobial agent is present in the UV-curable composition in the amount of from about 0.5 to about 30 parts, by weight, in comparison to 100 parts of the UV-curable material. In further embodiments of the UV-curable composition, the antimicrobial agent is present in the amount of from about 0.5 to about 20 parts, by weight, in comparison to 100 parts of the UV-curable material.
- In addition to the aforementioned materials, the UV-curable composition can comprise any other suitable component. Indeed, in certain embodiments, the UV-curable composition also includes a Theological modifier to improve the composition's flow characteristics and to help components be uniformly distributed throughout the composition. In such embodiments, the Theological modifier is preferably selected from organic clay, castor wax, polyamide wax, polyurethane, and fumed silica. Additionally, in such embodiments, the Theological modifier generally comprises from about 0.1 to about 30 parts, by weight, added to 100 parts, by weight, of the UV-curable material (i.e. the UV-curable material is 100 weight units, while the Theological modifier comprises from about 0.1 to about 30 parts of additional weight that is added to the 100 parts of the UV-curable material). In other embodiments, the Theological modifier comprises from 0.1 to about 20 parts by weight compared to 100 parts by weight of the UV-curable material. In certain further embodiments, the rheological modifier comprises from about 0.2 to about 10 parts by weight compared to 100 parts by weight of the UV-curable material.
- The UV-curable composition may also have any other suitable characteristic. For instance, in some embodiments, the UV-curable composition has a viscosity that is less than about 10,000 centipoises (cps). In other embodiments, the viscosity of the UV-curable composition is below about 5,000 cps. In some presently preferred embodiments, the UV-curable composition has a viscosity that is between about 20 and about 1,000 cps.
- While the UV-curable composition has been described above with specificity, a more detailed description of the UV-curable composition is found in U.S. patent application Ser. No. 12/397,760, filed Mar. 4, 2009, and entitled “Antimicrobial Compositions;” the entire disclosure of which is hereby incorporated by reference.
- Where the antimicrobial coating comprises an antimicrobial solution, the solution may comprise any suitable ingredient. In some embodiments, the antibacterial solution comprises an acrylate polymer or copolymer, a solvent, and an antimicrobial agent. To provide a better understanding of the antimicrobial solution, each of its aforementioned ingredients is described below in more detail.
- The acrylate polymer or copolymer can comprise any acrylate polymer and/or copolymer that is compatible with the other components of the antimicrobial solution and that is usable within the scope of the invention. In some embodiments, the acrylate-type polymer, copolymer, or polymer resin is insoluble in water while being soluble in one or more of the solvents that are discussed hereinafter. For example, the acrylate polymer or copolymer is generally selected from one or more alkyl acrylates, alkyl methacryloates, alkyl hydroxyl (meth) acrylates, and alkyl methoxycinnamate acrylates. In this example, the acrylate can be alkyl acrylate, alkyl hydroxyl (meth) acrylate, or alkyl methacrylate. Additionally, in this example, the alkyl group can have a carbon number from 0 to 22, wherein 0 means hydrogen, 1 means a methyl group, 2 means an ethyl group, 3 means a propyl group, etc.), but preferably a number from 0 to 6, and more preferably from 0 to 3.
- The solvent in the antimicrobial solution can comprise any solvent that is compatible with the other components of the antimicrobial solution and that allows the solution to function as intended. For instance, the solvent may comprise one or more of a variety of solvents that are capable of dissolving the aforementioned acrylate polymer or copolymer. Some examples of suitable solvents include one or more low molecular weight alcohols, low molecular weight alkanes, simple ketones, and combinations thereof. Some examples of suitable low molecular weight alcohols comprise alcohols having from 1 to 6 carbons (e.g., methanol, ethanol, propanol, isopropanol, and butanol). Because methanol evaporates relatively quickly, however, methanol may not be preferred in all embodiments. Instead, in some currently preferred embodiments, the solvent comprises ethanol or isopropanol. Some suitable examples of suitable low molecular weight alkanes comprise alkanes having from 5 to 7 carbons (e.g., pentane, hexane, heptane, and isomers thereof). Indeed, in some preferred embodiments the solvent comprises hexane and/or heptane. Additionally, an example of a suitable simple ketone is acetone. It should be noted, however, that in some embodiments that comprises acetone, the solvent preferably also comprises another solvent, such as an alcohol or an alkane.
- While the solvent may comprise any suitable amount of the antimicrobial solution, in some embodiments, the solvent comprises less than about 67% of the dry weight of the antimicrobial solution. For instance, where the polymer accounts for about 60%±10% of the antimicrobial solution, the solvent can account for less than about 40%±10% of the solution. In other embodiments, however, the solvent comprises less than about 50% of the dry weight of the composition. In still other embodiments, the solvent comprises less than about 40% of the dry weight of the composition.
- The antimicrobial agent in the antimicrobial solution can comprise any antimicrobial agent that is compatible with the other components of the solution and that allows the solution to function as intended. Indeed, the antimicrobial agent for the antimicrobial solution is generally selected from one or more aldehydes, anilides, biguanides, silver, silver compounds, bis-pheonols, and quaternary ammonium compounds. In certain instances, the antimicrobial agent is preferably selected from cetyl pyridium chloride, cetrimide, benzalkonium chloride, alexidine, chlorexidine diacetate, and o-phthalaldehyde.
- While the antimicrobial agent may comprise any suitable amount of the antimicrobial solution, in some embodiments, the antimicrobial agent comprises less than about 50% of the dry weight of the solution. In other embodiments, the antimicrobial comprises less than about 30% of the dry weight of the antimicrobial solution. In still other embodiments, the antimicrobial agent comprises about 0.5% and about 20% of the dry weight of the antimicrobial solution.
- In addition to the aforementioned ingredients, the antimicrobial solution may comprise any other suitable ingredient. Indeed, in some embodiments, the antimicrobial solution comprises a Theological modifier that is generally selected from organic clay, castor wax, polyamide wax, polyurethane, and fumed silica. In such embodiments, the Theological modifier is generally present in an amount of from about 0.2% to about 30% of the dry weight of the antimicrobial solution. That is, the weight of the composition once the solvent has evaporated. In certain other embodiments, the rheological modifier is present in the amount of from about 0.2% to about 20% of the dry weight of the antimicrobial solution. In certain other embodiments, the rheological modifier is present in an amount of from about 0.2% to about 10% of the dry weight of the antimicrobial solution.
- While the antimicrobial solution has been described above with specificity, a more detailed description of the antimicrobial solution is found in U.S. patent application Ser. No. 12/476,997, filed Jun. 2, 2009, and entitled “Antimicrobial Coating Compositions;” the entire disclosure of which is hereby incorporated by reference.
- The described methods can be performed or modified in any suitable manner. By way of example,
FIG. 2 illustrates one presently preferred embodiment of the described method for coating a medical device. Specifically,FIG. 2 shows an example in which themethod 11 begins at 12 by providing a medical device. - Next, at 13,
FIG. 2 shows themethod 10 optionally includes masking one or more desired portions of the medical device to prevent the antimicrobial coating from contacting the masked portion(s). By way of illustration,FIG. 3 shows that where the medical device comprises a portion of an IV access device 100 (e.g., BECTON DICKINSON's Q-SYTE® IV access device) having aLuer component 102, theLuer component 102 can be inserted into a medical-grade tube 104 so that the external surface of theLuer 102 is prevented from being coated with the antimicrobial coating. - Returning back to
FIG. 2 ,box 14 shows that themethod 10 continues by dispensing the antimicrobial coating (e.g., the UV-curable composition or the antimicrobial solution) onto the medical device. Any suitable amount of the antimicrobial coating can be dispensed onto the desired surface(s) of the medical device. For example, where the medical device comprises the IV access device ofFIG. 3 , between about 0.01 and about 0.05 grams of the antimicrobial coating can be dispensed into the device'sinner lumen 106. In still another example, where the medical device comprises the IV access device ofFIG. 3 , between 0.02 and about 0.04 grams of antimicrobial coating are dispensed into the device's inner lumen. - After the antimicrobial coating has been dispensed onto the medical device,
box 16 ofFIG. 2 shows that any excess coating on the device is flushed or otherwise removed from the medical device. In this manner, the antimicrobial coating can be caused to have a uniform thickness across the coated surface. The excess coating can be removed in any suitable manner, including by blowing an inert gas across the coated surface of the medical device, spinning the medical device in a centrifuge, by allowing excess material to drip from the device due to the pull of gravity, etc. Nevertheless, in some presently preferred embodiments, a pressured inert gas, such as nitrogen, helium, or argon, is blown across the coated surface. By way of example, where the medical device comprises theIV access device 100 ofFIG. 3 , an insert gas, such as nitrogen, with an air pressure of between about 5 and about 25 pounds per square inch (psi) (e.g., 10 psi±5 psi) is preferably blown past the coated surface. - In order to reduce the amount of antimicrobial coating that is wasted during the described method,
box 17 ofFIG. 2 shows that the excess antimicrobial coating that is flushed from the medical device is optionally collected and recycled. In other words, the excess antimicrobial coating can be collected and be used to coat another medical device. - With the excess antimicrobial coating removed from the medical device,
boxes box 20 shows that in some embodiments where the antimicrobial coating comprises the UV-curable composition, the UV-curable composition is cured by being exposed to UV light. In such embodiments, the UV-curable composition can be exposed to any suitable wavelength of UV light. In one example, the UV-curable composition is exposed to UV light with a wavelength of between about 320 to about 500 nm. In another example, the UV-curable composition is cross-linked by being exposed to light with a wavelength of between about 350 and about 450 nm. - Additionally, the UV-curable composition can be exposed to the UV light for any amount of time that allows the UV-curable composition to dry and be cured to the medical device. Indeed, in one example, the UV-curable composition is cured after less than about 1 minute of exposure to the UV light. In another example, the UV-curable coating is cured after less than about 30 seconds of exposure to the UV light. In still another example, the UV-curable coating is cured after less than about 10 seconds of exposure to the UV light. In a final example, the UV-curable coating is cured after less than about 4 seconds of exposure to the UV light.
- Referring now to
box 22,FIG. 2 shows that in some embodiments where the antimicrobial coating comprises the antimicrobial solution, the solution is cured through exposure to heat from a heat source (e.g., an infrared heater, a convectional heater, a conventional heater, etc.). In such embodiments, the antimicrobial solution coating the device can be cured at any suitable temperature. In one example, the solution is cured at a temperature of less than about 120° C. In another example, the antimicrobial solution is cured at a temperature of less than about 100° C. In still another example, the antimicrobial solution is cured at a temperature of less than about 60° C. - While the antimicrobial solution can be cured in any suitable amount of time, under certain conditions, the solution is cured after less than about 10 minutes of exposure to a temperature of less than about 60° C. Similarly, under certain conditions, the antimicrobial solution is cured after less than about 5 minutes of exposure to a temperature of less than about 100° C.
- Once the antimicrobial coating is cured,
box 24 ofFIG. 2 shows that any masking material is optionally removed from the medical device. At that point, the medical device can be used and the antimicrobial coating can be effective almost immediately after being exposed to a fluid (e.g., an IV fluid). - The described methods can be performed by any suitable system and/or apparatus that is capable of performing one or more of the features illustrated in
FIG. 2 . Indeed, in some embodiments, at least a portion of the described methods are performed by medical device coating system. While such a system can comprise any suitable component or characteristic,FIG. 4A illustrates a representative embodiment in which the medicaldevice coating system 200 comprises amedical device pallet 202, atop slide 204 having coating-dispending heads 206 and gas-dispensingheads 208, coatingvalves 210,gas valves 212, agas reservoir 214, excess funnels 216, and apressurized coating reservoir 218. - While the medical device coating system may be used in any suitable manner, in order to provide a better understanding of the system, a typical example of its use is provided herein. Specifically,
FIG. 4B shows that one or more medical devices, such as theIV access device 100, can be placed on themedical device pallet 202 so that anopening 108 to theinner lumen 106 of thedevice 100 is facing towards a coating-dispensing head 206 (shown inFIG. 4A ). - In order to ensure that the medical device stays in a proper orientation through the coating process, the pallet may secure the medical device in a desired orientation, in any suitable manner. By way of illustration,
FIG. 4B shows an embodiment in which theIV access device 100 is secured to thepallet 202 when alip 110 on theaccess device 100 is slid into agroove 220 on thepallet 202. - With the medical devices secured to the
pallet 202,FIG. 4A shows that thepallet 202 is placed beneath thetop slide 204. At this point, thetop slide 204 may move with respect to thepallet 202 so that acoating dispensing head 206 is disposed above the opening of each device (not shown inFIG. 4A ). - Once the dispensing heads are aligned with the surface of the medical device that is to be coated, the
coating valves 210 are opened to allow a predetermined amount (e.g., between about 0.01 and about 0.05 g) of antimicrobial coating to be squirt from thepressurized coating reservoir 218, through the coating-dispensingheads 206, and onto the medical device. While this dispensing process can take any suitable amount of time, in some instances, the dispensing process takes as little as 4 seconds or less (e.g., about 2 seconds+1 second). - After the coating has been dispensed, the
top slide 204 moves in the direction ofarrow 222 so that a gas-dispensinghead 208 is disposed above the coated surface of each medical device. Once the gas-dispensing heads are properly aligned, thetop slide 204 moves in the direction ofarrow 224 so that the gas-dispensingheads 208 form a seal against the medical device's opening (not shown inFIG. 4A ). Once a seal is formed, thegas valves 212 open to allow a controlled amount of the inert gas, at a controlled pressure, to flush any excess coating from the medical device. This excess coating is then collected in the excess funnels 216, which direct the excess coating back to thepressurized coating reservoir 218 for future use. - With the excess coating removed from the medical devices, the
pallet 202 can be removed from beneath thetop slide 204 and be placed in a curing chamber (not shown), such as a UV-light chamber or a heated chamber-depending on composition of the antimicrobial coating. - Following the curing process, the medical devices are removed from the pallet and new batch of uncoated medical devices can be placed in the pallet so that the process can be repeated.
- The described system can be modified in any suitable manner. In one example, while
FIG. 4A shows an embodiment in which thesystem 200 is configured to coat 4 medical devices simultaneously, the system can modified to simultaneously coat any suitable number of medical devices. For instance, the system can be modified to coat 1, 2, 3, 5, 6, 7, 8, or more medical devices, simultaneously. In another example, instead of comprising a coating-dispensing head and a separate gas-dispensing head, the antimicrobial coating and the inert gas may be dispensed to a medical device through single head so as to speed the time between the dispensing and flushing portions of the method. In yet another embodiment, the pallet, the gas dispensing head, or some other component in proximity to the medical devices can comprise a UV light source. In such embodiments, the system can cure the medical devices without requiring the pallet to be removed from a location beneath the top slide. - As discussed above, the described methods, apparatus, and compositions have several beneficial characteristics. In one example, the described methods allow a medical device to be coated with an antimicrobial coating (e.g., the UV-curable composition) in a relatively short period of time. For instance, instead of taking several hours (e.g., 24) to cure a harsh solvent (e.g., THF or DMF) onto a medical device, the UV-curable coating and the antimicrobial solution can be cured onto a medical device in a few second or minutes, respectively. Indeed, in some embodiments in which the antimicrobial coating comprises the UV-curable composition, the composition can be dispensed, flushed, and cured within about 30 seconds. In some preferred embodiments, the UV-curable composition can be dispensed, flushed, and cured within about 10 seconds. Similarly, in some embodiments in which the antimicrobial coating comprises the antimicrobial solution, the solution is dispensed, flushed, and cured within about 10 minutes. In some presently preferred embodiments, however, the antimicrobial solution is dispensed, flushed, and cured in less than about 5 minutes.
- In another example of a beneficial characteristic of the described methods, the methods can allow the antimicrobial coating to be applied to the medical device with a substantially uniform coating thickness. In still another example, because the described methods allow for excess antimicrobial coating to be recycled, the described methods may use less antimicrobial coating, overall, than certain conventional coating techniques.
- In yet another example, the described UV-curable and antimicrobial solutions provide several advantages over certain known antimicrobial coatings. For instance, the UV-curable and antimicrobial solutions can be less toxic, less expensive, more environmentally friendly, cause less deformation or cracking to a medical device, be more aesthetically pleasing, and require less-expensive equipment than do several competing antimicrobial coatings (e.g., THF and DMF).
- The present invention may be embodied in other specific forms without departing from its structures, methods, or other essential characteristics as broadly described herein and claimed hereinafter. The described embodiments and examples are to be considered in all respects only as illustrative, and not restrictive. The scope of the invention is, therefore, indicated by the appended claims, rather than by the foregoing description. All changes that come within the meaning and range of equivalency of the claims are to be embraced within their scope.
Claims (20)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/490,235 US20100136209A1 (en) | 2008-12-01 | 2009-06-23 | Systems and methods for applying an antimicrobial coating to a medical device |
CN2009801542796A CN102271826A (en) | 2008-12-01 | 2009-11-30 | Systems and methods for applying an antimicrobial coating to a medical device |
KR1020117015128A KR20110106328A (en) | 2008-12-01 | 2009-11-30 | Systems and methods for applying an antimicrobial coating to a medical device |
MX2011005738A MX349482B (en) | 2008-12-01 | 2009-11-30 | Systems and methods for applying an antimicrobial coating to a medical device. |
PCT/US2009/066122 WO2010065463A2 (en) | 2008-12-01 | 2009-11-30 | Systems and methods for applying an antimicrobial coating to a medical device |
EP09764422A EP2370210A2 (en) | 2008-12-01 | 2009-11-30 | Systems and methods for applying an antimicrobial coating to a medical device |
CA2745158A CA2745158A1 (en) | 2008-12-01 | 2009-11-30 | Systems and methods for applying an antimicrobial coating to a medical device |
BRPI0922699A BRPI0922699A2 (en) | 2008-12-01 | 2009-11-30 | systems and methods for applying an antimicrobial coating to a medical device |
AU2009322644A AU2009322644A1 (en) | 2008-12-01 | 2009-11-30 | Systems and methods for applying an antimicrobial coating to a medical device |
JP2011539615A JP5730213B2 (en) | 2008-12-01 | 2009-11-30 | System and method for applying antimicrobial coatings to medical devices |
ZA2011/04282A ZA201104282B (en) | 2008-12-01 | 2011-06-08 | Systems and methods for applying an antimicrobial coating to a medical device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11898808P | 2008-12-01 | 2008-12-01 | |
US12/490,235 US20100136209A1 (en) | 2008-12-01 | 2009-06-23 | Systems and methods for applying an antimicrobial coating to a medical device |
Publications (1)
Publication Number | Publication Date |
---|---|
US20100136209A1 true US20100136209A1 (en) | 2010-06-03 |
Family
ID=42223012
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/397,760 Abandoned US20100135949A1 (en) | 2008-12-01 | 2009-03-04 | Antimicrobial compositions |
US12/436,404 Active 2030-03-23 US8426348B2 (en) | 2008-12-01 | 2009-05-06 | Antimicrobial lubricant compositions |
US12/476,997 Active 2029-07-06 US8691887B2 (en) | 2008-12-01 | 2009-06-02 | Antimicrobial coating compositions |
US12/490,235 Abandoned US20100136209A1 (en) | 2008-12-01 | 2009-06-23 | Systems and methods for applying an antimicrobial coating to a medical device |
US13/867,901 Active US8754020B2 (en) | 2008-12-01 | 2013-04-22 | Antimicrobial lubricant compositions |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/397,760 Abandoned US20100135949A1 (en) | 2008-12-01 | 2009-03-04 | Antimicrobial compositions |
US12/436,404 Active 2030-03-23 US8426348B2 (en) | 2008-12-01 | 2009-05-06 | Antimicrobial lubricant compositions |
US12/476,997 Active 2029-07-06 US8691887B2 (en) | 2008-12-01 | 2009-06-02 | Antimicrobial coating compositions |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/867,901 Active US8754020B2 (en) | 2008-12-01 | 2013-04-22 | Antimicrobial lubricant compositions |
Country Status (12)
Country | Link |
---|---|
US (5) | US20100135949A1 (en) |
EP (4) | EP2370525B1 (en) |
JP (4) | JP5615289B2 (en) |
KR (4) | KR20110099293A (en) |
CN (4) | CN102272245A (en) |
AU (4) | AU2009322694B2 (en) |
BR (4) | BRPI0922354B1 (en) |
CA (4) | CA2745194C (en) |
ES (3) | ES2701624T3 (en) |
MX (4) | MX2011005730A (en) |
WO (4) | WO2010065421A1 (en) |
ZA (3) | ZA201104198B (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100137472A1 (en) * | 2008-12-01 | 2010-06-03 | Becton, Dickinson And Company | Antimicrobial coating compositions |
US8821455B2 (en) | 2009-07-09 | 2014-09-02 | Becton, Dickinson And Company | Antimicrobial coating for dermally invasive devices |
US20150027920A1 (en) * | 2013-07-25 | 2015-01-29 | Dennis Christopher Riordan | Medicine cup with infection control tab |
US9327095B2 (en) | 2013-03-11 | 2016-05-03 | Becton, Dickinson And Company | Blood control catheter with antimicrobial needle lube |
US9352119B2 (en) | 2012-05-15 | 2016-05-31 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
US9579486B2 (en) | 2012-08-22 | 2017-02-28 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
US9675793B2 (en) | 2014-04-23 | 2017-06-13 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
US9695323B2 (en) | 2013-02-13 | 2017-07-04 | Becton, Dickinson And Company | UV curable solventless antimicrobial compositions |
US9750928B2 (en) | 2013-02-13 | 2017-09-05 | Becton, Dickinson And Company | Blood control IV catheter with stationary septum activator |
US9750927B2 (en) | 2013-03-11 | 2017-09-05 | Becton, Dickinson And Company | Blood control catheter with antimicrobial needle lube |
US9789279B2 (en) | 2014-04-23 | 2017-10-17 | Becton, Dickinson And Company | Antimicrobial obturator for use with vascular access devices |
US10208429B2 (en) | 2010-09-10 | 2019-02-19 | Henkel IP & Holding GmbH | Adhesive having insulative properties |
US10232088B2 (en) | 2014-07-08 | 2019-03-19 | Becton, Dickinson And Company | Antimicrobial coating forming kink resistant feature on a vascular access device |
US10376686B2 (en) | 2014-04-23 | 2019-08-13 | Becton, Dickinson And Company | Antimicrobial caps for medical connectors |
US10493244B2 (en) | 2015-10-28 | 2019-12-03 | Becton, Dickinson And Company | Extension tubing strain relief |
US10543354B2 (en) | 2017-09-27 | 2020-01-28 | Becton, Dickinson And Company | Peripheral intravenous catheters having flow diverting features |
US11730862B2 (en) * | 2020-05-08 | 2023-08-22 | DePuy Synthes Products, Inc. | Identifier-based application of therapeutic coatings to medical implant devices |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
WO2013070951A1 (en) * | 2011-11-09 | 2013-05-16 | Arrow International, Inc. | Novel enhanced formulations for coating medical devices |
US11219706B2 (en) | 2009-03-11 | 2022-01-11 | Arrow International Llc | Enhanced formulations for coating medical devices |
WO2011139817A2 (en) | 2010-04-28 | 2011-11-10 | University Of Georgia Research Foundation, Inc. | Photochemical cross-linkable polymers, methods of marking photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers |
US20110301553A1 (en) * | 2010-06-04 | 2011-12-08 | Smiths Medical Asd, Inc. | Antimicrobial lubricant |
US8257827B1 (en) | 2011-06-02 | 2012-09-04 | The Regents Of The University Of California | Silicone composition and devices incorporating same |
CN103796704B (en) | 2011-07-12 | 2016-12-07 | 博讯瓦勒公司 | For the device that antimicrobial is delivered in percutaneous catheter |
US20140141230A1 (en) * | 2011-08-04 | 2014-05-22 | Jason J. Locklin | Permanent attachment of ammonium and guanidine-based antimicrobials to surfaces containing c-h functionality |
WO2013056007A2 (en) | 2011-10-14 | 2013-04-18 | University Of Georgia Research Foundation, Inc. | Photochemical cross-linkable polymers, methods of making photochemical cross-linkable plolymers, methods of using photochemical cross-linkable poloymers, and methods of making articles containing photochemical cross-linkable polymers |
BR112014023436B1 (en) | 2012-03-23 | 2021-05-04 | Massachusetts Institute Of Technology | container having surface impregnated with liquid and its manufacturing process |
JP5935133B2 (en) * | 2012-03-29 | 2016-06-15 | フジコピアン株式会社 | Hard coat film |
US20130255061A1 (en) * | 2012-04-03 | 2013-10-03 | Becton, Dickinson And Company | Systems and methods for applying a novel antimicrobial coating material to a medical device |
JP2015522839A (en) * | 2012-05-24 | 2015-08-06 | マサチューセッツ インスティテュート オブ テクノロジー | Apparatus having a liquid-impregnated surface |
US20130337027A1 (en) | 2012-05-24 | 2013-12-19 | Massachusetts Institute Of Technology | Medical Devices and Implements with Liquid-Impregnated Surfaces |
WO2014028203A1 (en) * | 2012-08-14 | 2014-02-20 | Henkel US IP LLC | Moisture and vapor barrier coating compositions |
KR101398301B1 (en) * | 2012-09-25 | 2014-05-27 | 주식회사 신바람 | Door with storage area |
US20140178611A1 (en) | 2012-11-19 | 2014-06-26 | Massachusetts Institute Of Technology | Apparatus and methods employing liquid-impregnated surfaces |
JP2016510252A (en) | 2012-11-19 | 2016-04-07 | マサチューセッツ インスティテュート オブ テクノロジー | Apparatus and method utilizing liquid impregnated surface |
JP6371301B2 (en) | 2012-12-11 | 2018-08-08 | ナノ セーフ コーティングス インコーポレイテッド(ア フロリダ コーポレーション 3 ピー14000024914)Nano Safe Coatings Incorporated(A Florida Corporation 3 P14000024914) | UV curable benzophenone-terminated quaternary ammonium antibacterial agent for surface |
AU2014211319B2 (en) * | 2013-02-01 | 2017-05-18 | Croda International Plc | Self-disinfecting surfaces |
EP2968677B1 (en) * | 2013-03-11 | 2018-02-21 | Teleflex Medical, Incorporated | Devices with anti-thrombogenic and anti-microbial treatment |
US8877882B1 (en) | 2013-10-04 | 2014-11-04 | Rochal Industries Llp | Non-self-adherent coating materials |
GB201322453D0 (en) * | 2013-12-18 | 2014-02-05 | Dow Corning | Antifriction coating |
US10792399B2 (en) | 2014-02-20 | 2020-10-06 | Becton, Dickinson And Company | Antimicrobial inserts for medical devices |
US10792398B2 (en) | 2014-02-20 | 2020-10-06 | Becton, Dickinson And Company | Antimicrobial inserts for medical devices |
KR20230153494A (en) | 2014-04-18 | 2023-11-06 | 백톤 디킨슨 앤드 컴퍼니 | Needle capture safety interlock for catheter |
WO2016168737A1 (en) | 2015-04-17 | 2016-10-20 | Becton, Dickinson And Company | Needle capture safety interlock for catheter |
US10149971B2 (en) | 2014-04-23 | 2018-12-11 | Becton, Dickinson And Company | Antimicrobial stopcock medical connector |
US20160008569A1 (en) * | 2014-07-08 | 2016-01-14 | Becton, Dickinson And Company | Antimicrobial actuator for opening the side port of a ported catheter |
US20160073937A1 (en) | 2014-09-11 | 2016-03-17 | Becton, Dickinson And Company | Blood sampling system for improving draw success and reducing hemolysis |
KR101641857B1 (en) * | 2014-11-26 | 2016-07-22 | 삼화페인트공업주식회사 | Antibacterial ultra-violet curing paint composition |
US10004890B2 (en) | 2015-01-27 | 2018-06-26 | Becton, Dickinson And Company | Antimicrobial inserts for stopcock medical connectors |
JP6822978B2 (en) | 2015-05-08 | 2021-01-27 | アイシーユー・メディカル・インコーポレーテッド | Medical connector configured to accept the emitter of a therapeutic agent |
EP3324739A4 (en) * | 2015-07-24 | 2019-02-13 | Teleflex Medical Incorporated | Antimicrobial compositions for surgical applications |
CN108430967A (en) | 2015-08-27 | 2018-08-21 | 纳米安全涂层公司(佛罗里达公司3 P 14000024914) | The preparation of the matrix treatments composition of antimicrobial containing sulfanilamide (SN) and the antimicrobial containing sulfanilamide (SN) |
JP6970668B2 (en) | 2015-10-28 | 2021-11-24 | ケアフュージョン 303、インコーポレイテッド | Closed IV access device with Y-port needle free connector |
KR101680003B1 (en) | 2016-01-26 | 2016-11-25 | (주)한도기공 | Automatic mixing roll for rubber mixing with symmetrical combination structure of extruding die and extruding screw |
DE102016108198A1 (en) * | 2016-05-03 | 2017-11-09 | B. Braun Avitum Ag | Medical device with antimicrobial surface coating and method for controlling microorganisms on the surface of such a device |
EP3525865B1 (en) | 2016-10-14 | 2022-10-12 | ICU Medical, Inc. | Sanitizing caps for medical connectors |
WO2018136274A1 (en) * | 2017-01-20 | 2018-07-26 | Medivators Inc. | Disposable valve for an endoscope having a lubricant and/or antimicrobial |
USD852368S1 (en) | 2017-03-27 | 2019-06-25 | Avery Dennison Corporation | Catheter dressing |
WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
KR102193014B1 (en) * | 2017-10-11 | 2020-12-18 | 주식회사 엘지화학 | Antibacterial polymer coating composition and antibacterial polymer film |
US10994101B2 (en) * | 2018-03-02 | 2021-05-04 | Becton, Dickinson And Company | Catheter assembly with high viscosity lubricant and related methods |
KR102112057B1 (en) * | 2018-07-13 | 2020-05-18 | (주)유니드 | Antibacterial, antifungal and high functional coating composition and products using this |
US11613719B2 (en) | 2018-09-24 | 2023-03-28 | Becton, Dickinson And Company | Self-lubricating medical articles |
CN110938365A (en) * | 2018-09-25 | 2020-03-31 | 天津大学 | Waterborne polyurethane antibacterial coating and preparation method thereof |
CN110938359A (en) * | 2018-09-25 | 2020-03-31 | 天津大学 | Method for improving antibacterial property of polyurethane coating by using hydrophilic chain extender |
US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
JP6838037B2 (en) * | 2018-11-16 | 2021-03-03 | イビデン株式会社 | Method of fixing antiviral cured product and method of manufacturing antiviral member |
US11433215B2 (en) | 2018-11-21 | 2022-09-06 | Icu Medical, Inc. | Antimicrobial device comprising a cap with ring and insert |
CN110041199B (en) * | 2019-01-23 | 2021-07-09 | 中山大学 | Monomer containing o-phthalaldehyde, polymer prepared from monomer, preparation method and application |
KR102636596B1 (en) * | 2019-01-31 | 2024-02-13 | 주식회사 엘지화학 | Antibacterial polymer coating composition and antibacterial polymer film |
KR102557941B1 (en) * | 2019-03-11 | 2023-07-19 | 주식회사 엘지화학 | Antibacterial polymer coating composition and antibacterial polymer film |
US11648385B2 (en) | 2019-05-30 | 2023-05-16 | Beeton, Dickinson and Company | Automatic disinfection of a vascular access device connector |
KR102450967B1 (en) * | 2019-12-06 | 2022-10-05 | 울산대학교 산학협력단 | Organic-inorganic emulsion composition for deodorization and antibacterial agent and fibrous mat having the composition |
CN111282777B (en) * | 2020-03-26 | 2022-07-12 | 苏州微比特自动化有限公司 | Coating and curing production line |
CN111955476A (en) * | 2020-09-03 | 2020-11-20 | 常熟理工学院 | LED light-cured pesticide microcapsule and preparation method thereof |
CN113694226A (en) * | 2021-08-20 | 2021-11-26 | 中山大学 | Method for synergistic sterilization, disinfection and biological adhesion prevention of ultraviolet sterilization corrosion inhibitor |
CN115340901A (en) * | 2022-09-22 | 2022-11-15 | 袁培锷 | Biolubricant compositions and methods of making the same |
Citations (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3223629A (en) * | 1963-05-13 | 1965-12-14 | Shell Oil Co | Lubricant compositions |
US3986508A (en) * | 1973-08-22 | 1976-10-19 | Abcor, Inc. | Sterilizable, medical connector for blood processing |
US4339336A (en) * | 1981-03-23 | 1982-07-13 | Texaco Inc. | Quaternary ammonium succinimide salt composition and lubricating oil containing same |
US4512766A (en) * | 1982-12-08 | 1985-04-23 | Whitman Medical Corporation | Catheter valve |
US4584192A (en) * | 1984-06-04 | 1986-04-22 | Minnesota Mining & Manufacturing Company | Film-forming composition containing an antimicrobial agent and methods of use |
US4629746A (en) * | 1985-01-26 | 1986-12-16 | Etablissement Dentaire Ivoclar | Radiopaque dental materials |
US4629743A (en) * | 1985-05-20 | 1986-12-16 | The B.F. Goodrich Company | Process for preparing high bulk density vinyl resins |
US4642126A (en) * | 1985-02-11 | 1987-02-10 | Norton Company | Coated abrasives with rapidly curable adhesives and controllable curvature |
US4677143A (en) * | 1984-10-01 | 1987-06-30 | Baxter Travenol Laboratories, Inc. | Antimicrobial compositions |
US4716032A (en) * | 1983-08-03 | 1987-12-29 | Geoffrey J. Westfall | Aerosol spray composition for mastitis prevention |
US4897427A (en) * | 1987-01-14 | 1990-01-30 | Sandoz Ltd. | Method of combatting pruning wound diseases |
US4915934A (en) * | 1983-10-24 | 1990-04-10 | Tomlinson Roderick P J | Foamable biocide composition |
US4925668A (en) * | 1989-01-18 | 1990-05-15 | Becton, Dickinson And Company | Anti-infective and lubricious medical articles and method for their preparation |
US4933178A (en) * | 1988-10-07 | 1990-06-12 | Biointerface Technologies, Inc. | Metal-based antimicrobial coating |
US5023082A (en) * | 1986-05-18 | 1991-06-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Sustained-release pharmaceutical compositions |
US5077352A (en) * | 1990-04-23 | 1991-12-31 | C. R. Bard, Inc. | Flexible lubricious organic coatings |
US5512199A (en) * | 1993-11-02 | 1996-04-30 | Becton Dickinson And Company | Hand wipe solution |
US5547662A (en) * | 1993-08-27 | 1996-08-20 | Becton, Dickinson And Company | Preparation of a skin surface for a surgical procedure |
US5616338A (en) * | 1988-02-11 | 1997-04-01 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
US5629006A (en) * | 1994-06-27 | 1997-05-13 | Becton, Dickinson And Company | Skin disinfecting formulations |
US5698229A (en) * | 1992-06-30 | 1997-12-16 | Toagosei Co., Ltd. | Antimicrobial composition |
US5773487A (en) * | 1991-05-15 | 1998-06-30 | Uv Coatings, Inc. | Finishing composition which is curable by UV light and method of using same |
US5861440A (en) * | 1993-04-19 | 1999-01-19 | Beiersdorf Aktiengesellschaft | Cosmetic and medicinal topical preparations |
US6051609A (en) * | 1997-09-09 | 2000-04-18 | Tristrata Technology, Inc. | Additives enhancing the effect of therapeutic agents |
US6127320A (en) * | 1998-01-19 | 2000-10-03 | University Of Cincinnati | Methods and compositions for increasing lubricity of rubber surfaces |
US6242526B1 (en) * | 1997-01-28 | 2001-06-05 | Stepan Company | Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes |
US6248811B1 (en) * | 1997-01-03 | 2001-06-19 | Huels Aktiengesellschaft | Bioactive surface coating |
US20010016589A1 (en) * | 1995-11-13 | 2001-08-23 | Shanta Modak | Triple antimicrobial composition |
US6326417B1 (en) * | 1999-10-21 | 2001-12-04 | Jeneric/Pentron Incorporated | Anti-microbial dental compositions and method |
US20010053895A1 (en) * | 2000-06-15 | 2001-12-20 | Vaillancourt Vincent L. | Bloodless catheter |
US20010056133A1 (en) * | 1998-02-19 | 2001-12-27 | Montgomery R. Eric | Curable compositions with antimicrobial properties |
US6337357B1 (en) * | 1997-02-24 | 2002-01-08 | Kuraray Co., Ltd. | Antimicrobial caries-detecting composition |
US20020022660A1 (en) * | 1998-01-20 | 2002-02-21 | Hanuman B. Jampani | Deep penetrating antimicrobial compositions |
US6353041B1 (en) * | 1999-10-22 | 2002-03-05 | Kerr Corporation | Dental compositions |
US20020028751A1 (en) * | 1999-10-27 | 2002-03-07 | Ecolab Inc. | Lubricant compositions having antimicrobial properties and methods for manufacturing and using lubricant compositions having antimicrobial properties |
US6413539B1 (en) * | 1996-10-31 | 2002-07-02 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
US20020119111A1 (en) * | 2000-06-12 | 2002-08-29 | General Electric Company | Silicone compositions |
US20020144705A1 (en) * | 2000-12-29 | 2002-10-10 | Brattesani Steven J. | Dental floss with usage identification capability |
US6488942B1 (en) * | 1997-10-18 | 2002-12-03 | Ddg Dental Devices Gmbh | Disinfecting agent |
US20030072781A1 (en) * | 1998-09-24 | 2003-04-17 | Advantage Dental Products, Inc. | Calcified tissue facing preparation containing antimicrobial agent |
US6576633B1 (en) * | 1996-02-22 | 2003-06-10 | The Dow Chemical Company | Stable liquid antimicrobial suspension compositions containing quarternaries prepared from hexamethylenetetramine and certain halohydrocarbons |
US20030119932A1 (en) * | 1999-12-08 | 2003-06-26 | Walid Al-Akhdar | Novel phosphine oxide photoinitiator systems and curable compostions with low color |
US20030147932A1 (en) * | 2001-08-10 | 2003-08-07 | Creavis Gesellschaft Fuer Tech. Und Innovation Mbh | Self-cleaning lotus effect surfaces having antimicrobial properties |
US20030162839A1 (en) * | 2000-04-03 | 2003-08-28 | Symington John Marston | Use of chlorhexidine in the prevention of root caries |
US20030170308A1 (en) * | 2001-05-01 | 2003-09-11 | Cleary Gary W. | Hydrogel compositions |
US20040014864A1 (en) * | 2002-05-15 | 2004-01-22 | Richard Milic | Decorative coating composition for solid substrates |
US20040039349A1 (en) * | 1996-01-05 | 2004-02-26 | Shanta Modak | Tricolosan-containing medical devices |
US20040058829A1 (en) * | 1999-08-16 | 2004-03-25 | Ecolab Inc. | Conveyor lubricant, passivation of a thermoplastic container to stress cracking and thermoplastic stress crack inhibitor |
US20040115477A1 (en) * | 2002-12-12 | 2004-06-17 | Bruce Nesbitt | Coating reinforcing underlayment and method of manufacturing same |
US20040185296A1 (en) * | 2001-07-04 | 2004-09-23 | Raffaello Mazzanti | Method for protecting a flooring or lining material from staining substances |
US20040234475A1 (en) * | 2001-06-22 | 2004-11-25 | Helene Lannibois-Drean | Oil-in-oil emulsions comprising a silicone, dispersions and use of said emulsions |
US6861060B1 (en) * | 2000-04-21 | 2005-03-01 | Elena Luriya | Personal care formulations |
US20050048005A1 (en) * | 2003-08-26 | 2005-03-03 | Stockel Richard F. | Antimicrobial compositions for dental applications |
US20050080158A1 (en) * | 2001-10-10 | 2005-04-14 | Ong Ivan W | Antimicrobial radiation curable coating |
US20050100580A1 (en) * | 2003-10-14 | 2005-05-12 | Cook Incorporated | Hydrophilic coated medical device |
US6896889B2 (en) * | 2001-04-06 | 2005-05-24 | L'oreal | Immediate effect anti-wrinkle composition, based on an aqueous dispersion, of at least one mineral filler |
US20050176905A1 (en) * | 2002-01-31 | 2005-08-11 | Woong-Sig Moon | Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof |
US20050265931A1 (en) * | 2002-06-21 | 2005-12-01 | Kerr Corporation | Silver-containing dental composition |
US20060051385A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
US7074839B2 (en) * | 2004-03-01 | 2006-07-11 | 3M Innovative Properties Company | Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups |
US20060165903A1 (en) * | 2002-10-01 | 2006-07-27 | Raffaello Mazzanti | Method for the decoration of porous ceramic materials and in particular polished porcelain stoneware |
US20060165751A1 (en) * | 2000-08-15 | 2006-07-27 | Chudzik Stephen J | Medicament incorporation matrix |
WO2006095648A1 (en) * | 2005-03-05 | 2006-09-14 | Kyoto University | Three-dimensional photonic crystal and method for producing the same |
US20060239954A1 (en) * | 2005-04-22 | 2006-10-26 | Sancho Karrie A | Antimicrobial spray for use on pets |
US20060258780A1 (en) * | 2002-12-30 | 2006-11-16 | Rhodia Chimie | Method for preparing a silica suspension in a potentially crosslinkable silicone material |
US20060281663A1 (en) * | 2005-06-13 | 2006-12-14 | 3M Innovative Properties Company | Foamable alcohol compositions, systems and methods of use |
US20070000407A1 (en) * | 2003-10-09 | 2007-01-04 | York International Corporation | Nano composite photocatalytic coating |
US7179849B2 (en) * | 1999-12-15 | 2007-02-20 | C. R. Bard, Inc. | Antimicrobial compositions containing colloids of oligodynamic metals |
US7198800B1 (en) * | 1999-11-23 | 2007-04-03 | Thomas Sai Ying Ko | Compositions and methods |
US20070112112A1 (en) * | 2005-11-15 | 2007-05-17 | Judith Kerschner | Swollen silicone composition and process of producing same |
US20070112146A1 (en) * | 2005-11-15 | 2007-05-17 | Benjamin Falk | Swollen silicone composition, process of producing same and products thereof |
US7232540B2 (en) * | 2004-05-02 | 2007-06-19 | Ashland Licensing And Intellectual Property Llc | Radiation-curable coatings for plastic substrates from multifunctional acrylate oligomers |
US20070141524A1 (en) * | 2005-12-20 | 2007-06-21 | Brennan Joan V | Dental compositions including radiation-to-heat converters, and the use thereof |
US20070160547A1 (en) * | 2006-01-11 | 2007-07-12 | Janet Duffy | Method of applying a composition |
US20070166344A1 (en) * | 2006-01-18 | 2007-07-19 | Xin Qu | Non-leaching surface-active film compositions for microbial adhesion prevention |
US20070202177A1 (en) * | 2006-02-28 | 2007-08-30 | Becton, Dickinson And Company | Antimicrobial Compositions and Methods for Locking Catheters |
US20070203574A1 (en) * | 2006-02-25 | 2007-08-30 | Mcgrath Terrence S | Ultraviolet activated antimicrobial surfaces |
US20070225179A1 (en) * | 2004-08-13 | 2007-09-27 | Markus Schutz | Lubricant for Sports Equipment |
US20070275101A1 (en) * | 2006-02-23 | 2007-11-29 | Lu Helen S | Removable antimicrobial coating compositions and methods of use |
US20080075761A1 (en) * | 2000-12-22 | 2008-03-27 | Modak Shanta M | Antimicrobial Medical Devices Containing Chlorhexidine Free Base And Salt |
US20080161763A1 (en) * | 2006-07-28 | 2008-07-03 | Becton, Dickinson And Company | Vascular access device antimicrobial materials and solutions |
US20080182921A1 (en) * | 2007-01-29 | 2008-07-31 | Bisco, Inc. | Dental Primer Adhesive System and Optional Hydrophobic Resin |
US7407707B2 (en) * | 2004-05-02 | 2008-08-05 | Ashland Licensing And Intellectual Property Llc | Radiation-curable coatings for metal substrates from multifunctional acrylate oligomers |
US7462401B2 (en) * | 2005-12-23 | 2008-12-09 | Xerox Corporation | Radiation curable composition |
US7494339B2 (en) * | 2005-08-10 | 2009-02-24 | Dentsply International, Inc. | Compositions for use as dental crowns and methods for preparing dental crowns |
US7498367B2 (en) * | 2005-02-21 | 2009-03-03 | Kerr Corporation | Acid-tolerant dental composition |
US7514477B2 (en) * | 2005-10-18 | 2009-04-07 | Derve-Otoplastik Gmbh | Low-viscosity radiation-curable composition for making an earpiece |
US20090110844A1 (en) * | 2007-10-26 | 2009-04-30 | Dymax Corporation | Photopolymerizable compositions containing an oxonol dye |
US20090114327A1 (en) * | 2005-04-08 | 2009-05-07 | Stefan Breunig | Composition based on siloxane for the moulding/unmoulding of tyres |
US20090117164A1 (en) * | 2005-08-22 | 2009-05-07 | Quick-Med Technologies, Inc. | Disinfectant with Durable Activity Based on Alcohol-Soluble Quaternary Ammonium Polymers and Copolymers |
US20090162530A1 (en) * | 2007-12-21 | 2009-06-25 | Orion Industries, Ltd. | Marked precoated medical device and method of manufacturing same |
US20090176907A1 (en) * | 2008-01-08 | 2009-07-09 | Ramesh Subramanian | Direct-to-metal radiation curable compositions |
US20090188559A1 (en) * | 2008-01-30 | 2009-07-30 | Nesbitt Jeffrey E | Ultraviolet cured coating system |
US20090220739A1 (en) * | 2005-12-09 | 2009-09-03 | Chougule Vivek A | Selectively permeable films |
US20090324666A1 (en) * | 2008-06-25 | 2009-12-31 | Baxter International Inc. | Methods for making antimicrobial resins |
US20110009831A1 (en) * | 2009-07-09 | 2011-01-13 | Becton, Dickinson And Company | Antimicrobial coating for dermally invasive devices |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4359564A (en) | 1980-03-14 | 1982-11-16 | Rohm & Haas Co. | Addition polymer of oligomeric polyesters of acrylic acid |
US5013717A (en) | 1988-04-18 | 1991-05-07 | Becton, Dickinson And Company | Blood compatible, lubricious article and composition and method therefor |
CA1331333C (en) * | 1988-07-20 | 1994-08-09 | Thomas M. Gentle | Antimicrobial antifoam compositions and methods |
DE4011867A1 (en) | 1990-04-12 | 1991-10-17 | Herberts Gmbh | Conductive, radiation-cured coating materials - contain radiation-curable monomer(s) oligomer(s) and/or polymer(s), mica pigment coated with antimony doped tin oxide photoinitiators, etc. |
JP2666654B2 (en) | 1992-04-01 | 1997-10-22 | 住友金属工業株式会社 | How to apply water-soluble rust preventive oil to steel |
JPH0751651A (en) * | 1993-08-19 | 1995-02-28 | Mitsubishi Materials Corp | Coating material for dirt prevention and deodorization |
JPH08209064A (en) | 1994-12-27 | 1996-08-13 | Ebihara:Kk | Antimicrobial coating material for fancy plywood |
JPH08311373A (en) * | 1995-05-22 | 1996-11-26 | Tokuyama Corp | Photo-setting composition for antimicrobial film |
JPH09151262A (en) | 1995-11-29 | 1997-06-10 | Fuji Silysia Chem Ltd | Surface-hardened resin plate |
JPH09157548A (en) | 1995-12-01 | 1997-06-17 | Sumitomo Chem Co Ltd | Antibacterial surface-coating agent and synthetic resin molding coated therewith |
WO1998058989A1 (en) | 1997-06-20 | 1998-12-30 | Coloplast A/S | A hydrophilic coating and a method for the preparation thereof |
US6110483A (en) * | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
WO1999032168A1 (en) | 1997-12-22 | 1999-07-01 | Becton Dickinson And Company | A material for use in medical devices with a self-replenishing antimicrobial and/or lubricious surface |
US6299980B1 (en) * | 1998-09-29 | 2001-10-09 | Medtronic Ave, Inc. | One step lubricious coating |
JP2000178475A (en) | 1998-12-15 | 2000-06-27 | Nisseki Kk | Antimicrobial deodorizing coating agent |
JP3824120B2 (en) * | 1999-03-18 | 2006-09-20 | 新東工業株式会社 | Photopolymerizable monomer composition having antibacterial properties, and solvent-free ultraviolet and electron beam curable resin compositions having antibacterial properties |
US6156373A (en) | 1999-05-03 | 2000-12-05 | Scimed Life Systems, Inc. | Medical device coating methods and devices |
US6706022B1 (en) | 1999-07-27 | 2004-03-16 | Alaris Medical Systems, Inc. | Needleless medical connector with expandable valve mechanism |
JP2001072438A (en) | 1999-08-31 | 2001-03-21 | Wako Kagaku Kogyo Kk | Antimicrobial processed flat glass material |
KR100405030B1 (en) | 2001-02-10 | 2003-11-10 | 주식회사 유레이 | New UV-curing antibacterial agents |
JP3730529B2 (en) | 2001-03-27 | 2006-01-05 | 日本ペイント株式会社 | Method and apparatus for coating porous material |
DE10144531B4 (en) * | 2001-09-11 | 2006-01-19 | Henkel Kgaa | UV-curable anti-fingerprint coatings, methods for coating and using a solvent-free coating agent |
NO320324B1 (en) | 2002-03-26 | 2005-11-21 | Jotun As | Polymers and monomers and their use as well as processes for preparing polymers and antifouling paints containing polymers |
JP2003342402A (en) | 2002-05-27 | 2003-12-03 | Mitsubishi Rayon Co Ltd | Antimicrobial resin molding having scratch resistance and production method therefor |
JP2004043669A (en) | 2002-07-12 | 2004-02-12 | Dainippon Toryo Co Ltd | Toning method for powdery coating material |
CN1487035A (en) * | 2002-08-07 | 2004-04-07 | 珠海东诚化工有限公司 | Ultraviolet ray cured insulating paint |
CN1247712C (en) | 2003-03-03 | 2006-03-29 | 珠海东诚化工有限公司 | Visible light cured metal paint |
JP2005028209A (en) | 2003-07-07 | 2005-02-03 | Dainippon Ink & Chem Inc | Antibacterial, mildew-proofing cured-film and formation method therefor |
WO2006036982A2 (en) * | 2004-09-28 | 2006-04-06 | Atrium Medical Corporation | Drug delivery coating for use with a stent |
WO2006056482A1 (en) | 2004-11-29 | 2006-06-01 | Dsm Ip Assets B.V. | Method for reducing the amount of migrateables of polymer coatings |
EP1841814B1 (en) | 2005-01-17 | 2009-11-18 | Biomodics | A method of coating a polymer surface with a polymer containing coating and an item comprising a polymer coated polymer |
WO2006099359A2 (en) * | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of reducing microbial contamination |
EP1898900B1 (en) * | 2005-03-10 | 2011-06-08 | 3M Innovative Properties Company | Antimicrobial compositions comprising esters of hydroxycarboxylic acids |
JP2007016096A (en) | 2005-07-06 | 2007-01-25 | Chugoku Marine Paints Ltd | Curable composition, composition for coating, coating material, antifouling coating material, cured product thereof and antifouling method of base material |
US20070048344A1 (en) * | 2005-08-31 | 2007-03-01 | Ali Yahiaoui | Antimicrobial composition |
US8227050B1 (en) * | 2005-10-31 | 2012-07-24 | E I Du Pont De Nemours And Company | Coating composition and method for coating substrates |
AU2007214450B2 (en) | 2006-02-14 | 2011-08-04 | Care Fusion 2200, Inc | Liquid applicator and method for reducing the concentration of by-products from antiseptic |
JP2010503737A (en) * | 2006-09-13 | 2010-02-04 | ディーエスエム アイピー アセッツ ビー.ブイ. | Antibacterial hydrophilic coating containing metallic silver particles |
PL2136645T3 (en) | 2007-04-18 | 2013-11-29 | Basf Se | Antimicrobial plastics and coatings |
EP2160097A2 (en) | 2007-04-25 | 2010-03-10 | Basf Se | Substrates with biocidal coating |
WO2009070227A1 (en) * | 2007-11-30 | 2009-06-04 | Corning Incorporated | Dense homogeneous fluoride films for duv elements and method of preparing same |
US8034455B2 (en) * | 2008-06-06 | 2011-10-11 | Novasolar Holdings Limited | Coating composition, substrates coated therewith and methods of making and using same |
US8178120B2 (en) * | 2008-06-20 | 2012-05-15 | Baxter International Inc. | Methods for processing substrates having an antimicrobial coating |
CN101353545B (en) | 2008-08-26 | 2010-06-23 | 苏州市明大高分子科技材料有限公司 | UV curing antibiotic coating and preparation thereof |
US20100135949A1 (en) * | 2008-12-01 | 2010-06-03 | Becton, Dickinson And Company | Antimicrobial compositions |
US20110065798A1 (en) | 2009-09-17 | 2011-03-17 | Becton, Dickinson And Company | Anti-infective lubricant for medical devices and methods for preparing the same |
-
2009
- 2009-03-04 US US12/397,760 patent/US20100135949A1/en not_active Abandoned
- 2009-05-06 US US12/436,404 patent/US8426348B2/en active Active
- 2009-06-02 US US12/476,997 patent/US8691887B2/en active Active
- 2009-06-23 US US12/490,235 patent/US20100136209A1/en not_active Abandoned
- 2009-11-25 WO PCT/US2009/065941 patent/WO2010065421A1/en active Application Filing
- 2009-11-25 JP JP2011539604A patent/JP5615289B2/en active Active
- 2009-11-25 BR BRPI0922354-1A patent/BRPI0922354B1/en active IP Right Grant
- 2009-11-25 AU AU2009322694A patent/AU2009322694B2/en active Active
- 2009-11-25 CN CN2009801542921A patent/CN102272245A/en active Pending
- 2009-11-25 JP JP2011539605A patent/JP6022771B2/en active Active
- 2009-11-25 WO PCT/US2009/065942 patent/WO2010065422A1/en active Application Filing
- 2009-11-25 CA CA2745194A patent/CA2745194C/en active Active
- 2009-11-25 MX MX2011005730A patent/MX2011005730A/en active IP Right Grant
- 2009-11-25 KR KR1020117015126A patent/KR20110099293A/en active Search and Examination
- 2009-11-25 AU AU2009322693A patent/AU2009322693B2/en active Active
- 2009-11-25 CA CA2745191A patent/CA2745191C/en active Active
- 2009-11-25 CN CN200980154281.3A patent/CN102272274B/en active Active
- 2009-11-25 MX MX2011005729A patent/MX336185B/en unknown
- 2009-11-25 EP EP09764419.9A patent/EP2370525B1/en active Active
- 2009-11-25 ES ES09764420T patent/ES2701624T3/en active Active
- 2009-11-25 EP EP09764420.7A patent/EP2370559B1/en active Active
- 2009-11-25 ES ES09764419.9T patent/ES2618803T3/en active Active
- 2009-11-25 BR BRPI0922357A patent/BRPI0922357A2/en not_active Application Discontinuation
- 2009-11-25 KR KR1020117015127A patent/KR101691679B1/en active IP Right Grant
- 2009-11-30 KR KR1020117015125A patent/KR101691678B1/en active IP Right Grant
- 2009-11-30 EP EP09764422A patent/EP2370210A2/en not_active Withdrawn
- 2009-11-30 JP JP2011539612A patent/JP5628195B2/en active Active
- 2009-11-30 BR BRPI0922697A patent/BRPI0922697A2/en not_active Application Discontinuation
- 2009-11-30 AU AU2009322644A patent/AU2009322644A1/en not_active Abandoned
- 2009-11-30 CA CA2745149A patent/CA2745149C/en active Active
- 2009-11-30 MX MX2011005739A patent/MX2011005739A/en active IP Right Grant
- 2009-11-30 CA CA2745158A patent/CA2745158A1/en not_active Abandoned
- 2009-11-30 EP EP09768270.2A patent/EP2370526B1/en active Active
- 2009-11-30 CN CN200980154283.2A patent/CN102272244B/en active Active
- 2009-11-30 KR KR1020117015128A patent/KR20110106328A/en not_active Application Discontinuation
- 2009-11-30 WO PCT/US2009/066080 patent/WO2010065445A1/en active Application Filing
- 2009-11-30 BR BRPI0922699A patent/BRPI0922699A2/en not_active Application Discontinuation
- 2009-11-30 JP JP2011539615A patent/JP5730213B2/en active Active
- 2009-11-30 ES ES09768270.2T patent/ES2643600T3/en active Active
- 2009-11-30 WO PCT/US2009/066122 patent/WO2010065463A2/en active Application Filing
- 2009-11-30 AU AU2009322626A patent/AU2009322626B2/en active Active
- 2009-11-30 CN CN2009801542796A patent/CN102271826A/en active Pending
- 2009-11-30 MX MX2011005738A patent/MX349482B/en active IP Right Grant
-
2011
- 2011-06-06 ZA ZA2011/04198A patent/ZA201104198B/en unknown
- 2011-06-06 ZA ZA2011/04197A patent/ZA201104197B/en unknown
- 2011-06-08 ZA ZA2011/04282A patent/ZA201104282B/en unknown
-
2013
- 2013-04-22 US US13/867,901 patent/US8754020B2/en active Active
Patent Citations (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3223629A (en) * | 1963-05-13 | 1965-12-14 | Shell Oil Co | Lubricant compositions |
US3986508A (en) * | 1973-08-22 | 1976-10-19 | Abcor, Inc. | Sterilizable, medical connector for blood processing |
US4339336A (en) * | 1981-03-23 | 1982-07-13 | Texaco Inc. | Quaternary ammonium succinimide salt composition and lubricating oil containing same |
US4512766A (en) * | 1982-12-08 | 1985-04-23 | Whitman Medical Corporation | Catheter valve |
US4716032A (en) * | 1983-08-03 | 1987-12-29 | Geoffrey J. Westfall | Aerosol spray composition for mastitis prevention |
US4915934A (en) * | 1983-10-24 | 1990-04-10 | Tomlinson Roderick P J | Foamable biocide composition |
US4584192A (en) * | 1984-06-04 | 1986-04-22 | Minnesota Mining & Manufacturing Company | Film-forming composition containing an antimicrobial agent and methods of use |
US4677143A (en) * | 1984-10-01 | 1987-06-30 | Baxter Travenol Laboratories, Inc. | Antimicrobial compositions |
US4629746A (en) * | 1985-01-26 | 1986-12-16 | Etablissement Dentaire Ivoclar | Radiopaque dental materials |
US4642126A (en) * | 1985-02-11 | 1987-02-10 | Norton Company | Coated abrasives with rapidly curable adhesives and controllable curvature |
US4629743A (en) * | 1985-05-20 | 1986-12-16 | The B.F. Goodrich Company | Process for preparing high bulk density vinyl resins |
US5023082A (en) * | 1986-05-18 | 1991-06-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Sustained-release pharmaceutical compositions |
US4897427A (en) * | 1987-01-14 | 1990-01-30 | Sandoz Ltd. | Method of combatting pruning wound diseases |
US5616338A (en) * | 1988-02-11 | 1997-04-01 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
US4933178A (en) * | 1988-10-07 | 1990-06-12 | Biointerface Technologies, Inc. | Metal-based antimicrobial coating |
US4925668A (en) * | 1989-01-18 | 1990-05-15 | Becton, Dickinson And Company | Anti-infective and lubricious medical articles and method for their preparation |
US5077352A (en) * | 1990-04-23 | 1991-12-31 | C. R. Bard, Inc. | Flexible lubricious organic coatings |
US5773487A (en) * | 1991-05-15 | 1998-06-30 | Uv Coatings, Inc. | Finishing composition which is curable by UV light and method of using same |
US5698229A (en) * | 1992-06-30 | 1997-12-16 | Toagosei Co., Ltd. | Antimicrobial composition |
US5861440A (en) * | 1993-04-19 | 1999-01-19 | Beiersdorf Aktiengesellschaft | Cosmetic and medicinal topical preparations |
US5547662A (en) * | 1993-08-27 | 1996-08-20 | Becton, Dickinson And Company | Preparation of a skin surface for a surgical procedure |
US5512199A (en) * | 1993-11-02 | 1996-04-30 | Becton Dickinson And Company | Hand wipe solution |
US5629006A (en) * | 1994-06-27 | 1997-05-13 | Becton, Dickinson And Company | Skin disinfecting formulations |
US20010016589A1 (en) * | 1995-11-13 | 2001-08-23 | Shanta Modak | Triple antimicrobial composition |
US20040039349A1 (en) * | 1996-01-05 | 2004-02-26 | Shanta Modak | Tricolosan-containing medical devices |
US6576633B1 (en) * | 1996-02-22 | 2003-06-10 | The Dow Chemical Company | Stable liquid antimicrobial suspension compositions containing quarternaries prepared from hexamethylenetetramine and certain halohydrocarbons |
US6413539B1 (en) * | 1996-10-31 | 2002-07-02 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
US6248811B1 (en) * | 1997-01-03 | 2001-06-19 | Huels Aktiengesellschaft | Bioactive surface coating |
US20020040092A1 (en) * | 1997-01-28 | 2002-04-04 | Stepan Company | Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealant, adhesives and elastomers produced from such latexes |
US6492445B2 (en) * | 1997-01-28 | 2002-12-10 | Stepan Company | Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes |
US6242526B1 (en) * | 1997-01-28 | 2001-06-05 | Stepan Company | Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes |
US6337357B1 (en) * | 1997-02-24 | 2002-01-08 | Kuraray Co., Ltd. | Antimicrobial caries-detecting composition |
US6051609A (en) * | 1997-09-09 | 2000-04-18 | Tristrata Technology, Inc. | Additives enhancing the effect of therapeutic agents |
US6488942B1 (en) * | 1997-10-18 | 2002-12-03 | Ddg Dental Devices Gmbh | Disinfecting agent |
US6127320A (en) * | 1998-01-19 | 2000-10-03 | University Of Cincinnati | Methods and compositions for increasing lubricity of rubber surfaces |
US20020022660A1 (en) * | 1998-01-20 | 2002-02-21 | Hanuman B. Jampani | Deep penetrating antimicrobial compositions |
US20010056133A1 (en) * | 1998-02-19 | 2001-12-27 | Montgomery R. Eric | Curable compositions with antimicrobial properties |
US20030072781A1 (en) * | 1998-09-24 | 2003-04-17 | Advantage Dental Products, Inc. | Calcified tissue facing preparation containing antimicrobial agent |
US20040058829A1 (en) * | 1999-08-16 | 2004-03-25 | Ecolab Inc. | Conveyor lubricant, passivation of a thermoplastic container to stress cracking and thermoplastic stress crack inhibitor |
US6326417B1 (en) * | 1999-10-21 | 2001-12-04 | Jeneric/Pentron Incorporated | Anti-microbial dental compositions and method |
US6353041B1 (en) * | 1999-10-22 | 2002-03-05 | Kerr Corporation | Dental compositions |
US20020028751A1 (en) * | 1999-10-27 | 2002-03-07 | Ecolab Inc. | Lubricant compositions having antimicrobial properties and methods for manufacturing and using lubricant compositions having antimicrobial properties |
US7198800B1 (en) * | 1999-11-23 | 2007-04-03 | Thomas Sai Ying Ko | Compositions and methods |
US20030119932A1 (en) * | 1999-12-08 | 2003-06-26 | Walid Al-Akhdar | Novel phosphine oxide photoinitiator systems and curable compostions with low color |
US7179849B2 (en) * | 1999-12-15 | 2007-02-20 | C. R. Bard, Inc. | Antimicrobial compositions containing colloids of oligodynamic metals |
US20030162839A1 (en) * | 2000-04-03 | 2003-08-28 | Symington John Marston | Use of chlorhexidine in the prevention of root caries |
US6861060B1 (en) * | 2000-04-21 | 2005-03-01 | Elena Luriya | Personal care formulations |
US20020119111A1 (en) * | 2000-06-12 | 2002-08-29 | General Electric Company | Silicone compositions |
US20010053895A1 (en) * | 2000-06-15 | 2001-12-20 | Vaillancourt Vincent L. | Bloodless catheter |
US20060165751A1 (en) * | 2000-08-15 | 2006-07-27 | Chudzik Stephen J | Medicament incorporation matrix |
US20080075761A1 (en) * | 2000-12-22 | 2008-03-27 | Modak Shanta M | Antimicrobial Medical Devices Containing Chlorhexidine Free Base And Salt |
US20020144705A1 (en) * | 2000-12-29 | 2002-10-10 | Brattesani Steven J. | Dental floss with usage identification capability |
US6896889B2 (en) * | 2001-04-06 | 2005-05-24 | L'oreal | Immediate effect anti-wrinkle composition, based on an aqueous dispersion, of at least one mineral filler |
US20030170308A1 (en) * | 2001-05-01 | 2003-09-11 | Cleary Gary W. | Hydrogel compositions |
US20040234475A1 (en) * | 2001-06-22 | 2004-11-25 | Helene Lannibois-Drean | Oil-in-oil emulsions comprising a silicone, dispersions and use of said emulsions |
US20040185296A1 (en) * | 2001-07-04 | 2004-09-23 | Raffaello Mazzanti | Method for protecting a flooring or lining material from staining substances |
US20030147932A1 (en) * | 2001-08-10 | 2003-08-07 | Creavis Gesellschaft Fuer Tech. Und Innovation Mbh | Self-cleaning lotus effect surfaces having antimicrobial properties |
US20050080158A1 (en) * | 2001-10-10 | 2005-04-14 | Ong Ivan W | Antimicrobial radiation curable coating |
US7098256B2 (en) * | 2001-10-10 | 2006-08-29 | Microban Products Company | Antimicrobial radiation curable coating |
US20050176905A1 (en) * | 2002-01-31 | 2005-08-11 | Woong-Sig Moon | Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof |
US20040014864A1 (en) * | 2002-05-15 | 2004-01-22 | Richard Milic | Decorative coating composition for solid substrates |
US20050265931A1 (en) * | 2002-06-21 | 2005-12-01 | Kerr Corporation | Silver-containing dental composition |
US20060165903A1 (en) * | 2002-10-01 | 2006-07-27 | Raffaello Mazzanti | Method for the decoration of porous ceramic materials and in particular polished porcelain stoneware |
US20040115477A1 (en) * | 2002-12-12 | 2004-06-17 | Bruce Nesbitt | Coating reinforcing underlayment and method of manufacturing same |
US7261925B2 (en) * | 2002-12-12 | 2007-08-28 | Orion Industries Ltd. | Coating reinforcing underlayment and method of manufacturing same |
US20060258780A1 (en) * | 2002-12-30 | 2006-11-16 | Rhodia Chimie | Method for preparing a silica suspension in a potentially crosslinkable silicone material |
US20050048005A1 (en) * | 2003-08-26 | 2005-03-03 | Stockel Richard F. | Antimicrobial compositions for dental applications |
US20070000407A1 (en) * | 2003-10-09 | 2007-01-04 | York International Corporation | Nano composite photocatalytic coating |
US20050100580A1 (en) * | 2003-10-14 | 2005-05-12 | Cook Incorporated | Hydrophilic coated medical device |
US7074839B2 (en) * | 2004-03-01 | 2006-07-11 | 3M Innovative Properties Company | Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups |
US7232540B2 (en) * | 2004-05-02 | 2007-06-19 | Ashland Licensing And Intellectual Property Llc | Radiation-curable coatings for plastic substrates from multifunctional acrylate oligomers |
US7407707B2 (en) * | 2004-05-02 | 2008-08-05 | Ashland Licensing And Intellectual Property Llc | Radiation-curable coatings for metal substrates from multifunctional acrylate oligomers |
US20070225179A1 (en) * | 2004-08-13 | 2007-09-27 | Markus Schutz | Lubricant for Sports Equipment |
US20060051385A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
US7498367B2 (en) * | 2005-02-21 | 2009-03-03 | Kerr Corporation | Acid-tolerant dental composition |
WO2006095648A1 (en) * | 2005-03-05 | 2006-09-14 | Kyoto University | Three-dimensional photonic crystal and method for producing the same |
US20090114327A1 (en) * | 2005-04-08 | 2009-05-07 | Stefan Breunig | Composition based on siloxane for the moulding/unmoulding of tyres |
US20060239954A1 (en) * | 2005-04-22 | 2006-10-26 | Sancho Karrie A | Antimicrobial spray for use on pets |
US20060281663A1 (en) * | 2005-06-13 | 2006-12-14 | 3M Innovative Properties Company | Foamable alcohol compositions, systems and methods of use |
US7494339B2 (en) * | 2005-08-10 | 2009-02-24 | Dentsply International, Inc. | Compositions for use as dental crowns and methods for preparing dental crowns |
US20090117164A1 (en) * | 2005-08-22 | 2009-05-07 | Quick-Med Technologies, Inc. | Disinfectant with Durable Activity Based on Alcohol-Soluble Quaternary Ammonium Polymers and Copolymers |
US7514477B2 (en) * | 2005-10-18 | 2009-04-07 | Derve-Otoplastik Gmbh | Low-viscosity radiation-curable composition for making an earpiece |
US20070112112A1 (en) * | 2005-11-15 | 2007-05-17 | Judith Kerschner | Swollen silicone composition and process of producing same |
US20070112146A1 (en) * | 2005-11-15 | 2007-05-17 | Benjamin Falk | Swollen silicone composition, process of producing same and products thereof |
US20090220739A1 (en) * | 2005-12-09 | 2009-09-03 | Chougule Vivek A | Selectively permeable films |
US20070141524A1 (en) * | 2005-12-20 | 2007-06-21 | Brennan Joan V | Dental compositions including radiation-to-heat converters, and the use thereof |
US7462401B2 (en) * | 2005-12-23 | 2008-12-09 | Xerox Corporation | Radiation curable composition |
US20070160547A1 (en) * | 2006-01-11 | 2007-07-12 | Janet Duffy | Method of applying a composition |
US20070166344A1 (en) * | 2006-01-18 | 2007-07-19 | Xin Qu | Non-leaching surface-active film compositions for microbial adhesion prevention |
US20070275101A1 (en) * | 2006-02-23 | 2007-11-29 | Lu Helen S | Removable antimicrobial coating compositions and methods of use |
US20080026026A1 (en) * | 2006-02-23 | 2008-01-31 | Lu Helen S | Removable antimicrobial coating compositions and methods of use |
US20070203574A1 (en) * | 2006-02-25 | 2007-08-30 | Mcgrath Terrence S | Ultraviolet activated antimicrobial surfaces |
US20070202177A1 (en) * | 2006-02-28 | 2007-08-30 | Becton, Dickinson And Company | Antimicrobial Compositions and Methods for Locking Catheters |
US20080161763A1 (en) * | 2006-07-28 | 2008-07-03 | Becton, Dickinson And Company | Vascular access device antimicrobial materials and solutions |
US20080182921A1 (en) * | 2007-01-29 | 2008-07-31 | Bisco, Inc. | Dental Primer Adhesive System and Optional Hydrophobic Resin |
US20090110844A1 (en) * | 2007-10-26 | 2009-04-30 | Dymax Corporation | Photopolymerizable compositions containing an oxonol dye |
US20090162530A1 (en) * | 2007-12-21 | 2009-06-25 | Orion Industries, Ltd. | Marked precoated medical device and method of manufacturing same |
US20090176907A1 (en) * | 2008-01-08 | 2009-07-09 | Ramesh Subramanian | Direct-to-metal radiation curable compositions |
US20090188559A1 (en) * | 2008-01-30 | 2009-07-30 | Nesbitt Jeffrey E | Ultraviolet cured coating system |
US20090324666A1 (en) * | 2008-06-25 | 2009-12-31 | Baxter International Inc. | Methods for making antimicrobial resins |
US20110009831A1 (en) * | 2009-07-09 | 2011-01-13 | Becton, Dickinson And Company | Antimicrobial coating for dermally invasive devices |
Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8691887B2 (en) | 2008-12-01 | 2014-04-08 | Becton, Dickinson And Company | Antimicrobial coating compositions |
US8754020B2 (en) | 2008-12-01 | 2014-06-17 | Becton, Dickinson And Company | Antimicrobial lubricant compositions |
US20100137472A1 (en) * | 2008-12-01 | 2010-06-03 | Becton, Dickinson And Company | Antimicrobial coating compositions |
US8821455B2 (en) | 2009-07-09 | 2014-09-02 | Becton, Dickinson And Company | Antimicrobial coating for dermally invasive devices |
US10208429B2 (en) | 2010-09-10 | 2019-02-19 | Henkel IP & Holding GmbH | Adhesive having insulative properties |
US9770580B2 (en) | 2012-05-15 | 2017-09-26 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
US9352119B2 (en) | 2012-05-15 | 2016-05-31 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
US9579486B2 (en) | 2012-08-22 | 2017-02-28 | Becton, Dickinson And Company | Blood control IV catheter with antimicrobial properties |
US9750928B2 (en) | 2013-02-13 | 2017-09-05 | Becton, Dickinson And Company | Blood control IV catheter with stationary septum activator |
US11357962B2 (en) | 2013-02-13 | 2022-06-14 | Becton, Dickinson And Company | Blood control IV catheter with stationary septum activator |
US9695323B2 (en) | 2013-02-13 | 2017-07-04 | Becton, Dickinson And Company | UV curable solventless antimicrobial compositions |
US9750927B2 (en) | 2013-03-11 | 2017-09-05 | Becton, Dickinson And Company | Blood control catheter with antimicrobial needle lube |
US9327095B2 (en) | 2013-03-11 | 2016-05-03 | Becton, Dickinson And Company | Blood control catheter with antimicrobial needle lube |
US9789280B2 (en) | 2013-03-11 | 2017-10-17 | Becton, Dickinson And Company | Blood control catheter with antimicrobial needle lube |
US20160067145A1 (en) * | 2013-07-25 | 2016-03-10 | Dennis Christopher Riordan | Medicine cup with infection control tab |
US20150027920A1 (en) * | 2013-07-25 | 2015-01-29 | Dennis Christopher Riordan | Medicine cup with infection control tab |
US10857069B2 (en) * | 2013-07-25 | 2020-12-08 | Dennis Christopher Riordan | Medicine cup with infection control tab |
US9789279B2 (en) | 2014-04-23 | 2017-10-17 | Becton, Dickinson And Company | Antimicrobial obturator for use with vascular access devices |
US10376686B2 (en) | 2014-04-23 | 2019-08-13 | Becton, Dickinson And Company | Antimicrobial caps for medical connectors |
US10589063B2 (en) | 2014-04-23 | 2020-03-17 | Becton, Dickinson And Company | Antimicrobial obturator for use with vascular access devices |
US9956379B2 (en) | 2014-04-23 | 2018-05-01 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
US9675793B2 (en) | 2014-04-23 | 2017-06-13 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
US11357965B2 (en) | 2014-04-23 | 2022-06-14 | Becton, Dickinson And Company | Antimicrobial caps for medical connectors |
US10232088B2 (en) | 2014-07-08 | 2019-03-19 | Becton, Dickinson And Company | Antimicrobial coating forming kink resistant feature on a vascular access device |
US11219705B2 (en) | 2014-07-08 | 2022-01-11 | Becton, Dickinson And Company | Antimicrobial coating forming kink resistant feature on a vascular access device |
US10493244B2 (en) | 2015-10-28 | 2019-12-03 | Becton, Dickinson And Company | Extension tubing strain relief |
US11904114B2 (en) | 2015-10-28 | 2024-02-20 | Becton, Dickinson And Company | Extension tubing strain relief |
US10543354B2 (en) | 2017-09-27 | 2020-01-28 | Becton, Dickinson And Company | Peripheral intravenous catheters having flow diverting features |
US11452857B2 (en) | 2017-09-27 | 2022-09-27 | Beeton, Dickinson and Company | Peripheral intravenous catheters having flow diverting features |
US11730862B2 (en) * | 2020-05-08 | 2023-08-22 | DePuy Synthes Products, Inc. | Identifier-based application of therapeutic coatings to medical implant devices |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20100136209A1 (en) | Systems and methods for applying an antimicrobial coating to a medical device | |
CA2900355C (en) | Uv curable solventless antimicrobial compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BECTON, DICKINSON AND COMPANY,NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:OU-YANG, DAVID T.;KHAN, AZHAR;CLUFF, KEN;REEL/FRAME:022864/0455 Effective date: 20090618 |
|
AS | Assignment |
Owner name: BECTON, DICKINSON AND COMPANY, NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:OU-YANG, DAVID T.;KHAN, AZHAR;CLUFF, KEN;REEL/FRAME:026773/0608 Effective date: 20110729 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |