US20110008462A1 - System and method for therapeutic application of dissolved oxygen - Google Patents
System and method for therapeutic application of dissolved oxygen Download PDFInfo
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- US20110008462A1 US20110008462A1 US12/697,846 US69784610A US2011008462A1 US 20110008462 A1 US20110008462 A1 US 20110008462A1 US 69784610 A US69784610 A US 69784610A US 2011008462 A1 US2011008462 A1 US 2011008462A1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K63/00—Receptacles for live fish, e.g. aquaria; Terraria
- A01K63/04—Arrangements for treating water specially adapted to receptacles for live fish
- A01K63/042—Introducing gases into the water, e.g. aerators, air pumps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/233—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids using driven stirrers with completely immersed stirring elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/43—Mixing liquids with liquids; Emulsifying using driven stirrers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/43—Mixing liquids with liquids; Emulsifying using driven stirrers
- B01F23/431—Mixing liquids with liquids; Emulsifying using driven stirrers the liquids being introduced from the outside through or along the axis of a rotating stirrer, e.g. the stirrer rotating due to the reaction of the introduced liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
- B01F27/2713—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator the surfaces having a conical shape
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
- B01F27/2723—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces the surfaces having a conical shape
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/20—Treatment of water, waste water, or sewage by degassing, i.e. liberation of dissolved gases
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/305—Treatment of water, waste water or sewage
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/001—Processes for the treatment of water whereby the filtration technique is of importance
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/34—Treatment of water, waste water, or sewage with mechanical oscillations
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/68—Treatment of water, waste water, or sewage by addition of specified substances, e.g. trace elements, for ameliorating potable water
- C02F1/685—Devices for dosing the additives
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/72—Treatment of water, waste water, or sewage by oxidation
- C02F1/727—Treatment of water, waste water, or sewage by oxidation using pure oxygen or oxygen rich gas
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/72—Treatment of water, waste water, or sewage by oxidation
- C02F1/78—Treatment of water, waste water, or sewage by oxidation with ozone
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2101/00—Nature of the contaminant
- C02F2101/30—Organic compounds
- C02F2101/32—Hydrocarbons, e.g. oil
- C02F2101/322—Volatile compounds, e.g. benzene
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2303/00—Specific treatment goals
- C02F2303/04—Disinfection
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F9/00—Multistage treatment of water, waste water or sewage
Definitions
- This invention relates in general to diffusers and, more particularly, to a method and apparatus for diffusing or emulsifying a gas or liquid into a material.
- This invention relates in general to diffusers and, more particularly, to a method and apparatus for diffusing or emulsifying a gas or liquid into a material.
- the oxygen available in water or other liquids often has a therapeutic value.
- eyes have a minimum necessary oxygen requirement.
- the continued presence of oxygen on the eye can be difficult to maintain when wearing contact lenses, particularly when contacts are worn during sleep when the eyes are closed.
- oxygen passes through the water in the lens.
- the oxygen content of the water used in the manufacture, storage, cleaning and wetting of contact lenses is an important factor in their manufacture and use.
- a contact lens wearer's ocular tissue can be damaged by a lack of oxygen.
- Contact lenses are designed in order to maximize the amount of oxygen reaching the cornea, keeping the eyes fresh and healthy all day long
- Emulsification is a subset of the process of diffusion wherein small globules of one liquid are suspended in a second liquid with which the first will not mix, such as oil into vinegar.
- wastewater treatment Many municipalities aerate their wastewater as part of the treatment process in order to stimulate biological degradation of organic matter. The rate of biological digestion of organic matter is very dependent upon the amount of oxygen in the wastewater, since the oxygen is necessary to sustain the life of the microorganisms which consume the organic matter. Additionally, oxygen is able to remove some compounds, such as iron, magnesium and carbon dioxide.
- a system and method for generating an oxygen enriched aqueous solution for therapeutic application includes a diffuser comprising a first diffusing member having a surface incorporating surface disturbances, and a second diffusing member positioned relative to the first diffusing member to form a channel through which an aqueous solution and oxygen gas may flow.
- a reservoir containing the aqueous solution is connected to a pump that draws the aqueous solution from the reservoir and inputs the aqueous solution into the diffuser.
- the aqueous solution is moved through the channel relative to the surface disturbances to create cavitation in the aqueous solution to diffuse the oxygen gas into the aqueous solution to produce an oxygen enriched aqueous solution.
- FIGS. 1 and 1 a illustrate a partially cross sectional, partially block diagram of a first embodiment of a diffuser
- FIGS. 2 a , 2 b and 2 c illustrate the diffusion process internal to the diffuser
- FIG. 3 illustrates an exploded view of the rotor and stator of the diffuser
- FIG. 4 illustrates an embodiment of the stator
- FIG. 5 a illustrates a cross-section view of the rotor-stator assembly in a second embodiment of the invention
- FIG. 5 b illustrates a top view of the rotor in the second embodiment of the invention
- FIG. 6 illustrates a cut-away view of a third embodiment of the invention
- FIGS. 8 a and 8 b illustrate another alternative embodiment of the invention
- FIG. 9 illustrates a schematic drawing of a method for producing oxygenated solutions using a diffuser in accordance with the present invention.
- FIGS. 10 a through 10 c illustrate an oxygenated solution and its application to the eye as drops or as contact lens solution
- FIG. 11 illustrates the storage and transportation of organs or living tissues in a container filled with oxygenated solution.
- FIG. 12 illustrates the storage and transportation of organs or living tissue using a system having a container of oxygenated solution and having a portable pump and diffuser recirculation system;
- FIG. 13 illustrates the delivery of oxygenated medicine, plasma, or other intravenous fluid to a patient
- FIG. 14 illustrates the use of oxygenated solution in hydrotherapy or other topical application to a patient
- FIG. 15 illustrates an alternative embodiment of a pump and diffuser system constructed in accordance with a disclosed embodiment
- FIG. 16 illustrates a simplified nanocage
- FIG. 17 illustrates an eye
- FIG. 18 illustrates a cut-away view of a contact lens
- FIG. 19 illustrates a spin-cast process for forming a contact lens
- FIG. 20 illustrates a lathe cutting process for forming a contact lens
- FIG. 21 illustrates a mold casting process for forming a contact lens
- FIG. 22 illustrates an eyewash station.
- FIGS. 1-8 of the drawings like numerals being used for like elements of the various drawings.
- FIGS. 1 and 1 a illustrate a partially block diagram, partially cross-sectional view first embodiment of a device 10 capable of diffusing or emulsifying one or two gaseous or liquid materials (hereinafter the “infusion materials”) into another gaseous or liquid material (hereinafter the “host material”).
- the host material may be a normally solid material which is heated or otherwise processed to be in a liquid or gaseous state during the diffusion/emulsification process.
- a rotor 12 comprises a hollow cylinder, generally closed at both ends.
- Shaft 14 and inlet 16 are coupled to the ends of the rotor 12 .
- a first infusion material can pass through inlet 16 into the interior of rotor 12 .
- Shaft 14 is coupled to a motor 18 , which rotates the rotor at a desired speed.
- the rotor 12 has a plurality of openings 22 formed there through, shown in greater detail in FIG. 1 a .
- the openings 22 each have a narrow orifice 24 and a larger borehole 26 .
- the sidewalls 28 of the boreholes 26 can assume various shapes including straight (as shown in FIG. 4 ), angled (as shown in FIG. 1 ) or curved.
- a stator 30 encompasses the rotor 12 , leaving a channel 32 between the rotor and the stator through which the host material may flow.
- the stator 30 also has openings 22 formed about its circumference.
- a housing 34 surrounds the stator 30 and inlet 36 passes a second infusion material to an area 35 between the stator 30 and the housing 34 .
- the host material passes through inlet 37 into the channel 32 .
- Seals 38 are formed between the shafts 14 and 16 and the housing 34 .
- An outlet 40 passes the host material from the channel 32 to a pump 42 , where it exits via pump outlet 44 .
- the pump may also be driven by motor 18 or by an auxiliary source.
- the diffusion device receives the host material through inlet 37 .
- pump 42 draws the host material on the pump's suction side in order to allow the host material to pass through the channel at low pressures.
- the first and second infusion materials are introduced to the host material through openings 22 .
- the infusion materials may be pressurized at their source to prevent the host material from passing through openings 22 .
- FIG. 1 has separate inlets for 16 and 36 for the diffusion materials. This arrangement allows two different infusion materials to be introduced to the host material. Alternatively, a single infusion material could be introduced into both inlets.
- the embodiment shown in FIG. 1 has demonstrated high levels of diffusion of the infusion material(s) into the host material.
- Tests using oxygen as the infusion material and water as the host material have resulted in levels of 400% dissolved oxygen in the water, with the increased oxygen levels lasting for days.
- the reason for the high efficiency and persistence of the diffusion is believed to be the result of micro-cavitation, which is described in connection with FIGS. 2 a - c .
- a rather laminar flow is established with a thin boundary layer that is stationary or moving very slowly because of the surface tension between the moving fluid and the stationary surface.
- the openings 22 disrupt the laminar flow and can cause compression and decompression of the material. If the pressure during the decompression cycle is low enough, voids (cavitation bubbles) will form in the material.
- the cavitation bubbles generate a rotary flow pattern 46 , like a tornado, because the localized area of low pressure draws the host material and the infusion material, as shown in FIG.
- the tangential velocity of the rotor 12 and the number of openings that pass each other per rotation dictate the frequency at which the device operates. It has been found that operation in the ultrasonic frequency can be beneficial in many applications. It is believed that operating the device in the ultrasonic region of frequencies provides the maximum succussion shock energy to shift the bonding angle of the fluid molecule, which enables it to transport additional infusion materials which it would not normally be able to retain. The frequency at which the diffuser operates appears to affect the degree of diffusion, leading to much longer persistence of the infusion material in the host material.
- a particular frequency or frequencies may be desired to break down certain complex molecules, such as in the case of water purification.
- multiple frequencies of succussion can be used to break complex structures, such as VOCs (volatile organic compounds), into smaller sub-structures.
- Ozone can be used as one of the infusion materials to oxidize the sub-structures at a high efficiency.
- sonochemistry uses ultrasound to assist chemical reactions.
- the ultrasound is generated using a piezoelectric or other electro-acoustical device.
- electro-acoustical transducers A problem associated with electro-acoustical transducers is that the sound waves do not provide uniform sound waves throughout the material; rather, the desired cavitation is localized around the device itself
- the present invention allows the ultrasonic waves to be produced throughout a material using a simple mechanical device.
- FIG. 3 illustrates an exploded view of an embodiment of the rotor 12 and stator 30 where multiple frequencies may be obtained at a single rotational velocity.
- three circular arrays of openings 50 (shown individually as arrays 50 a , 50 b , and 50 c ) of openings 22 are disposed circumferentially about the rotor 12 .
- Each ring has a different number of openings evenly spaced about its circumference.
- the stator 30 would have three circular arrays of openings 52 (shown individually as arrays 52 a , 52 b , and 52 c ).
- the number of openings 22 in a given array 52 on the stator 30 can be one more (or less) than the number of openings 22 in the corresponding array 50 of the rotor 12 .
- array 50 a had twenty openings evenly spaced around the circumference of rotor 12
- array 52 could have 21 openings spaced evenly around the circumference of stator 30 .
- each array will create succussions at a different frequency.
- a sum and difference interference pattern will result, creating a wide spectrum of frequencies. This spectrum of frequencies can be beneficial in many applications where unknown impurities in a host liquid need to be broken down and oxidized.
- FIG. 4 illustrates a cross-sectional side view of an embodiment of a stator 30 .
- the embodiment of FIG. 4 uses an inner sleeve 54 and an outer sleeve 56 .
- the boreholes 26 can be drilled, from the outside, of the inner sleeve 54 .
- a corresponding aligned orifice 24 is drilled on the outer sleeve 56 .
- the inner sleeve 54 is then placed in, and secured to, the outer sleeve 56 to form the stator 30 .
- Other methods, such as casting, could also be used to form the stator 30 .
- FIGS. 5 a - b and 6 illustrate alternative embodiments of the diffuser 10 . Where appropriate, reference numerals from FIG. 1 are repeated in these figures.
- FIG. 5 a illustrates an cross-sectional side view of an embodiment where the rotor 12 and stator 30 are disk shaped.
- FIG. 5 b illustrates a top view of the disk shaped rotor 12 .
- the stator 30 is formed above and below the rotor 12 .
- Both the stator 12 and rotor 30 have a plurality of openings of the type described in connection with FIG. 1 , which pass by each other as the rotor 12 is driven by the motor.
- the stator 30 may have one opening more or less than the corresponding array 50 in rotor 12 in order to prevent simultaneous succussion at two openings within an array.
- the openings 22 can be of the same shape as shown in FIG. 1 .
- a hollow shaft serves as the inlet 16 to the interior of the disk shaped rotor for the first infusion material.
- an area 35 between the stator 30 and the housing 34 receives the second infusion material.
- FIG. 5 b illustrates a top view of the rotor 12 .
- a plurality of openings forms concentric arrays of openings on the rotor 12 .
- Each array can, if desired, generate secussions at different frequencies.
- openings 22 would be formed on the top and bottom of the rotor 12 .
- Corresponding openings would be formed above and below these openings on the stator 30 .
- FIG. 6 illustrates a cut away view of an embodiment of the invention where the rotor 12 has a conical shape.
- Both the stator 12 and rotor 30 have a plurality of openings of the type described in connection with FIG. 1 , which pass by each other as the rotor 12 is driven by the motor.
- the stator 30 may have one opening more or less than the rotor 12 in order to prevent simultaneous succussion at two openings 22 on the same array.
- a hollow shaft serves as the inlet 16 to the interior of the disk shaped rotor for the first infusion material.
- an area 35 between the stator 30 and the housing 34 receives the second infusion material.
- the infused host material passes to outlets 40 .
- the diffuser described herein can be used in a number of applications. Optimal opening size (for both the orifice 24 and borehole 26 ), width of channel 32 , rotational speed and rotor/stator diameters may be dependent upon the application of the device.
- the diffuser 10 may be used for water aeration.
- air or oxygen is used as both the first and second infusion materials.
- the air/oxygen is diffused into the wastewater (or other water needing aeration) as described in connection with FIG. 1 . It has been found that the diffuser can increase the oxygenation to approximately 400% dissolved oxygen, with greater concentrations expected as parameters are optimized for this application. In tests which circulated approximately twenty five gallons of municipal water at ambient temperatures (initially having a reading of 84.4% dissolved oxygen) through the device for five minutes to achieve 390% dissolved oxygen content, the enhanced concentration of oxygen levels remained above 300% dissolved oxygen for a period of four hours and above 200% dissolved oxygen for over 19 hours.
- oxygen could be used as one of the infusion materials and ozone could be used as the other infusion material.
- the ozone would be used to oxidize hazardous structures in the host material, such as VOCs and dangerous microorganism.
- a set of frequencies (as determined by the arrays of openings in the rotor 12 and stator 30 ) could be used to provide an destructive interference pattern which would break down many of the complex structures into smaller substructures.
- a set of frequencies which result in a constructive interference pattern could be used to combine two or more compounds into a more complex and highly structured substance.
- ozone could be used as the first and second infusion material to break down and oxidize contaminants.
- the diffuser 10 While the operation of the diffuser 10 has been discussed in connection with large applications, such as municipal wastewater remediation, it could also be used in household applications, such as drinking water purifiers, swimming pools and aquariums.
- the diffuser could also be used for other applications where diffusion of a gas or liquid into another liquid changes the characteristics of the host material. Examples of such applications would include the homogenization of milk or the hydrogenation of oils. Other applications could include higher efficiencies in mixing fuel and gases/liquids resulting in higher fuel economy.
- FIGS. 7 a - b illustrate alternative embodiments for the rotor 12 and stator 30 .
- the “stator” 30 also rotates; in this case, the frequency of the succussions will be dependent upon the relative rotational speed between the rotor 12 and stator 30 .
- one of either the rotor 12 or stator 30 does not pass an infusion material through the component (in FIG. 7 b only the rotor passes an infusion material); the component which does not pass an infusion material has its openings 22 replaced by cavities 58 to produce the turbulence.
- the cavities 58 could be shaped similarly to the boreholes 26 without the accompanying orifices 24 .
- the orifice 24 through which the infusion material is passed through the rotor 12 or stator 30 is positioned next to the borehole 26 , rather than in the borehole 26 as in previous embodiments.
- the primary purpose of the borehole 26 is to disrupt the laminar flow of the host material along the surface of the rotor 12 and stator 30 .
- the compression and rarefaction (decompression) of the host material causes the micro-cavitation, which provides the high degree of diffusion produced by the device.
- voids cavitation bubbles
- the cavitation bubbles grow and contract (or implode) subject to the stresses induced by the frequencies of the succussions.
- Implosions of cavitation bubbles produce the energy which contribute to the high degree of diffusion of the infusion materials into the host material as it passes through the channel 32 .
- the diffusion described above will result.
- FIG. 7 d illustrates an embodiment where the initial mixing of the host material and one or more infusion materials is performed outside of channel 32 .
- a Mazzie diffuser 60 (or other device) is used to perform the initial mixing of the infusion material(s) and the host material.
- the mixture is input into the channel 32 between the rotor 12 and stator 30 , wherein undergoes the compression/rarefaction cycles discussed above, which cause cavitation in the mixture, and is subjected to the frequency of the shock waves.
- the generation of the cavitation and shock waves could be performed using structures which differ from the boreholes 26 shown in the embodiments above.
- the boreholes 26 are surface disturbances which impede the laminar flow of the host material along the sidewalls of the channel 32 .
- a protrusion such as bump 62 could be used as a surface disturbance in place of or in conjunction with the boreholes 26 .
- Shapes other than rounded shapes could also be used.
- grooves (or ridges) 64 could be formed in the rotor 12 and/or stator 30 to generate the cavitation and shock waves.
- the rotor 12 or stator 30 could have the boreholes 26 (or other surface disturbances) arranged such that a white noise was produced, rather than a particular frequency.
- the structures used to create the cavitation need not be uniform; a sufficiently rough surface be formed on the rotor 12 or stator 30 will cause the cavitation. Additionally, as shown in FIG. 7 g , it may not be necessary for both the surface of the rotor 12 and the surface of the stator 30 to create the cavitation; however, in most cases, operation of the device 10 will be more efficient if both surfaces are used.
- FIG. 7 h illustrates a embodiment where the movement which causes the cavitation is provided by the host material (optionally with entrained infused material) rather than by relative motion of the rotor 12 and stator 30 .
- the channel 32 is formed between two walls 66 which are static relative to one another, one or both of which have surface disturbances facing the channel 32 .
- the host material is driven through the channel at high speed using a pump or other device for creating a high speed flow.
- One or more infusion materials are input into the channel, either through orifices 24 or by mixing the host material with the infusion materials external to the channel.
- the high speed of the host material relative to the walls 66 causes the micro-cavitation and succussions described above.
- one or more of the walls 66 could be a fine mesh, through which the infusion material(s) flows to mix with the host material in the channel 32 .
- the surface disturbances in the mesh would cause micro-cavitations and succussions as the host material flows over the mesh at high speed.
- the frequency of the succussions would depend upon the resolution of the mesh and the speed of the host material.
- the infusion materials would diffuse into the host material at the molecular level at the micro-cavitation sites.
- FIGS. 8 a and 8 b illustrate another embodiment, where a rotating member 70 is disposed within a conduit 72 and rotated by motor 73 .
- the host material and infusion material(s) are mixed in the conduit 72 upstream from the rotating member 70 using a Mazzie diffuser 74 or other device.
- the rotating member could be, for example, propeller or auger shaped.
- On the surface of the rotating member 70 has one or more surface disturbances 76 , such that the rotation of the rotating member 70 creates the micro cavitation discussed above, thereby causing a high degree of diffusion between the materials.
- the shape of the propeller blades and pattern of the surface disturbances 76 thereon could create the cavitation and succussion at a desired frequency for purposes described above. Further, the shape of the rotating device could draw the materials through the conduit.
- the micro-cavitations generated by the device allow diffusion to occur at a molecular level, increasing the amount of infusion material which will be held by the host material and the persistence of the diffusion.
- the micro-cavitations and shock waves can be produced by a relatively simple mechanical device.
- the frequency or frequencies of the shock wave produced by the device can be used in many applications, either to break down complex structures or to aid in combining structures.
- the cavitations and shock waves can be produced uniformly throughout a material for consistent diffusion.
- FIG. 9 illustrates a schematic representation of a method for producing oxygenated solutions using a diffuser constructed in accordance with the present invention.
- the oxygenation system 90 comprises a supply or reservoir 91 of solution which is drawn up and circulated through tubing or other conduits by a pump 92 which subsequently delivers the solution to the diffuser 95 .
- the diffuser 95 may be of any number of various embodiments including those set forth and described herein above in regard to FIGS. 1 through 8 b .
- diffusers significantly increase the amount of dissolved oxygen (DO) present in a solution by introducing gaseous oxygen to the solution using a diffuser having coaxial cylindrical or frusto conical stator and rotor components rotating discs or plates within a housing, Mazzie diffusers and impellers to create the desired cavitation and succussion desired for mixing of the solution and the gas.
- DO dissolved oxygen
- many of the solutions will be aqueous or water-based, but that the present invention is not limited to these solutions and is believed to work with other liquid mediums as well.
- the diffuser 95 is supplied with solution by the pump 92 and combines this with gaseous oxygen from supply 94 and returns the oxygenated solution to the reservoir 91 .
- the diffuser 95 may employ any number of possible embodiments for achieving diffusion including, but not limited to, micro-membrane, Mazzi injector, fine bubble, vortexing, electromolecular activation, or other methods known in the art.
- the oxygen supply 94 may be either a cylinder of compressed oxygen gas or a system for generating oxygen gas from the air or other chemical components.
- the oxygenated solution produced by the diffuser 95 is returned to the reservoir 91 and may be recirculated through the pump 92 and the diffuser 95 again to further attempt to increase the dissolved oxygen content or may be drawn off using the oxygenated solution outlet 97 . Oxygenated solutions which are drawn off through the outlet 97 may be immediately put to use in various applications or alternatively may be packaged for later use.
- the packaging step 98 may enclose oxygenated solutions in a variety of bottles, bags or other containers formed of plastic, metal, glass, or other suitable materials. Although the oxygenated solutions produced in accordance with the present invention have a relatively long shelf life under atmospheric conditions, the shelf life may be further extended by using packaging which hermetically seals the oxygenated solution. In this manner, dissolved oxygen which works its way out of the solution during storage will form a pressure head above the oxygenated solution and help to prevent the migration of dissolved oxygen out of the solution and back into the atmosphere. In one preferred embodiment of the present invention the oxygenated solution is packaged in an air tight container and the void space is filled with nitrogen or other inert gas at a pressure of greater than one atmosphere prior to sealing the container. The packaging step 98 may be used to produce bottles, bags, pouches, or other suitable containers for holding oxygenated solutions.
- a diffusion system in accordance with the present invention it is possible to significantly increase the amount of dissolved gas in most liquids.
- the system and method allows oxygen to be dissolved stably at a high concentration with minimal passive loss.
- This system and method can be effectively used to dissolve a wide variety of gases at heightened percentages into a wide variety of liquids.
- a de-ionized water at room temperature that typcially has levels of about 2-3 ppm (parts per million) of dissolved oxygen can achieve levels of dissolved oxygen ranging from about 8-70 ppm using the disclosed system and method.
- an oxygenated water solution may be generated with levels of about 30-60 ppm of dissolved oxygen.
- a protonated water cluster typically takes the form of H + (H 2 0) n .
- Some protonated water clusters occur naturally, such as in the ionosphere.
- OH + molecules 202 bind to form a nanocage 200 .
- Oxygen atoms 204 may be caught in the resulting nanocage 200 .
- the chemistry of the semi-bound nanocage allows the oxygen 204 to remain dissolved for extended periods of time, far in excess of the natural evaporation rate of oxygen is unprocessed water.
- Oxygen is known or purported to have a wide variety of therapeutic and medicinal benefits. Among these benefits are faster healing and cell regrowth, improved resistance to disease, and increased energy or vitality. Increasing the level of dissolved oxygen in a liquid may increase the therapeutic and medicinal benefits of the liquid. These oxygenated liquids may be ingested, applied topically, injected or used in medicinal or therapeutic equipment or processes.
- gases having therapeutic or medicinal benefits may similarly be dissolved at heightened levels into liquids to increase the therapeutic and medicinal benefits of the liquid.
- the synergy of a heightened level of a gas in a liquid may provide therapeutic or medicinal qualities.
- an eye 206 is shown.
- Light is admitted through the pupil 210 .
- the cornea 208 is the transparent gel-like coating of the eye 206 which covers the pupil 210 and iris 109 .
- Tear ducts 212 at the corner of the eye 206 provide tears to continually moisten the cornea 208 .
- People use contact lenses to correct refractive disorders of the eye 206 such as myopia, hyperopia and astigmatism. Lack of oxygen available to the cornea 206 , which is covered by the contact lens can be major source of trouble for contact-lens wearers.
- An oxygen-rich solution may be used to formulate an eye-drop that patients can use daily to optimize contact lens wear and thereby provide enhanced levels of oxygen to the contact-lens covered cornea 208 .
- the aerated water produced in accordance with the disclosed systems and methods may be used in the manufacture, storage or care of contact lenses. Heightened levels of dissolved gas may increase the potency or safety of solutions used to store, clean, or moisten contact lenses.
- Contact lenses 214 are typically formed of soft polymer substances and may generally be divided into the categories of hydrophilic and hydrophobic lenses. Hydrophilic contact lenses 214 have a water content in excess of ten percent while hydrophobic lenses have water content of less than ten percent.
- the oxygen permeability of a contact lens 214 depends largely on the specific polymer used to form the lens. The oxygen permeability may be increased by using an aerated water to hydrate the polymer when the lens is created.
- Contact lenses may be made from a variety of commercially available materials, such as hydrophilic polymers (e.g., hydrogels) or poly(methyl methacrylate).
- a typical hydrogel polymer composition may consist of a reaction product of hydrophilic methacrylamide as well as an acrylic monomer, which may contain a zwitterionic monomer, such as a sulfobetaine, for example, N-(3-sulfopropyl)-N-methacryloxyethyl-N,N-dimethylammonium betaine (SPE), in order to improve the water-retention capability
- a sulfobetaine for example, N-(3-sulfopropyl)-N-methacryloxyethyl-N,N-dimethylammonium betaine (SPE)
- the contact lens 214 has a generally dome shape in its entirety.
- a contact lens 214 is typically worn on a cornea 208 of a lens wearer with its back surface 218 held in contact with a surface of the cornea 208 via tear fluid, as is well known in the art.
- the contact lens 214 has a center axis 222 approximately aligned with an optical axis of the lens, and is shaped as a solid of revolution about the center axis 222 .
- FIG. 18 shows only a symmetrical half of the contact lens 214 in its diametrical cross section.
- the contact lens 214 includes a front surface 216 and the back surface 218 .
- a central portion of the front surface 216 serves as a front optical zone, while a central portion of the back surface 218 serves as a back optical zone.
- These front and back optical zones have circular shapes in a plane view or as seen in a direction of the optical axis 222 , and cooperate with each other to form an optical zone provided with a suitable degree of dioptric power for vision correction.
- These circular front and back optical zones have centers located on the center axis 222 , and have different diameters.
- a spin casting contact lens production process 224 including aerated water produced in accordance with the disclosed methods is shown.
- Liquid monomer 228 is injected into a spinning mold 226 to create the a contact lens 230 with a desired lens shape, thickness and size.
- the monomer 228 is distributed along the mold 226 according to centrifugal force, gravity and surface tension of the liquid 228 . Slower rotations produce smaller diameters, thicker centers, flatter base curves and plus powers. The opposite is true for faster rotations.
- UV light 232 is used to polymerize the monomer 228 into a solid lens 280 .
- the lens 230 is then hydrated in a solution of oxygenated water 236 to its final state.
- a contact lens 230 with an increased oxygen permeability can be formed.
- a lathe cutting contact lens production process including aerated water produced in accordance with the disclosed methods is shown.
- a polymerized soft lens material 238 in the rigid state is cut into the desired contact lens shape using a lathe 240 .
- the contact lens 242 is polished using a polishing tool 241 or chemical process.
- the polished contact lens 242 is then hydrated in a oxygenated hydrating solution 244 to create the final soft contact lens 242 .
- the final soft contact lens 242 is hydrated with aerated water 244 to a specific water content, where the water content depends primarily on the polymer used.
- a cast molding contact lens production process 246 including aerated water produced in accordance with the disclosed methods is shown.
- a liquid monomer 248 is injected between two molds 250 and 252 .
- the monomer is polymerized into a solid form 254 , which is then removed from the molds 250 and 252 and hydrated using aerated water 256 .
- Another cast molding technique maintains the lens 254 in a liquid state during the hydration. This technique minimized variations in lens parameters caused by the hydration process.
- an ultraviolet mask allows the monomer within a central clear zone to be polymerized. The extra monomer can be washed away. This process produces precise edges, decreasing complications caused by rough edges formed in other techniques.
- FIGS. 10 a through 10 c illustrate various applications of oxygenated solutions for use as eye drops or contact lens solution.
- a variety of oxygenated liquids may be used as eye drops or contact lens solutions.
- Typical contact lens solutions are made for rinsing, cleaning and disinfecting the contact lenses.
- the oxygenated solution 101 may be packaged in a bottle or other sealed container 100 provided with a pipette or eye dropper 102 for use in various ocular applications.
- a pipette or eye dropper 102 for use in various ocular applications.
- One such application is that of an oxygenated saline solution for use as eye drops or artificial tears 103 .
- the moisturizing eye drops 103 may be applied directly to the eye using the eye dropper 102 and applying two or three drops 103 per application directly to the eye 104 to alleviate dry eyes, redness, allergic reactions, and to provide additional moisture to the corneal region 208 of the eye.
- oxygenate other solutions such as various aqueous medications that might be applied topically to the surface of the eye 206 .
- This may be particularly useful to patients that have recently had surgery performed on the cornea 208 or other areas of the eye 206 to improve vision (i.e., laser keratotomy, lasic, intralasic, and so forth) or to alleviate or lessen the effects of glaucoma.
- Aging eyes 206 often become dry as a result of lowered tear production due to problems with the tear ducts 212 . This problem is particularly marked in women. Seventeen percent of menopausal women us tear supplements to maintain stable vision and eye comfort. The most immediate patho-physiological problem produced by lower tear volume in these patients is the lack of dissolved oxygen from the air which has only a smaller volume to diffuse to reach the eye. Using an aerated solution with heightened levels of dissolved oxygen may be used with positive effects as a tear supplement.
- FIG. 10 b another alternative application of an oxygenated solution in contact with the eye is shown.
- the oxygenation process may also be applied to contact lens solutions such as saline solutions.
- a contact lens 106 is normally stored in a solution to keep the semipermeable polymer membrane moist and flexible.
- a contact lens 106 which has been stored in a lens solution is normally disposed just above the cornea of the eye 104 .
- the contact lens 106 will normally float just above the surface of the cornea on a layer of solution which may comprise the oxygenated saline solution 105 in which the lens has been stored.
- the oxygenated saline solution should increase the amount dissolved oxygen near the cornea of the eye and should help the eye to absorb greater amounts of oxygen that is usually possible with a contact lens in place.
- FIG. 10 c illustrates the storage of a pair of contact lenses 109 in a storage container 108 .
- the storage container 108 has a pair of shallow recesses for containing an oxygenated contact lens solution 107 which is used to provide a suitable storage environment for the contact lenses 109 .
- Contact lenses 109 are normally formed of thin polymer membranes which are semi-permeable to oxygen gas and which must be kept moist to retain their flexibility and other physical property characteristics.
- the contact lens solution 107 may be oxygenated using the disclosed processes.
- the solutions are typically a saline solution which is intended to mimic natural tears and which will be readily accepted by the body. However, the solution may further include various agents to help reduce the build up of proteins or other residues on the surface of the lens which may impair vision or cause some discomfort to the wearer.
- oxygen-rich solution can be used in artificial blood and blood-perfusing medicinal procedures such as coronary bypass surgery and shock-trauma procedures.
- oxygen-rich solutions may be used to perfuse solid organs, such as livers, kidneys, hearts, etc., in transit for transplantation and at the time of surgery. Use of oxygenated solutions produced in accordance with the disclosed embodiments may lead to longer storage time and better transplant results.
- FIG. 11 illustrates a container and method of transporting or storing organs, organic samples, test subjects other living tissues using oxygenated solution.
- the storage system 110 comprises an oxygenated solution 112 which has been poured into a storage container 114 and holds a specified volume of oxygenated storage medium 116 containing an organ or other living tissues 118 .
- the container 114 may be insulated or provided with a portable refrigeration unit (not shown) and may further include various impellers or other circulators for moving the oxygenated solution on and about all the surfaces of the living tissues 118 which are being stored or transported for transplantation. In this manner, it is believed that living tissues will be better preserved with less cell damage prior to transplantation.
- FIG. 12 illustrates an alternative system for storing and transporting living tissues and organs.
- the system 120 comprises a container 121 holding an oxygenated storage medium 122 and living tissues 124 which is to be stored or transported for transplantation.
- the system 120 further comprises a circulation pump 125 which draws solution 122 and combines the solution with oxygen gas from the supply 126 using a diffuser 127 constructed in accordance with the present invention.
- the pump, diffuser, and other components of the transportation and storage system may be provided with a portable power supply in the form of one or more batteries 128 or a hydrogen fuel cell.
- oxygenated storage medium 122 By storing and transporting organs and other living tissues 124 in an oxygenated storage medium 122 , it is possible to reduce damage to cells and living tissues outside the body and to supply these tissues to transplantation candidates in a healthier condition. By using oxygenated solutions as a storage and transportation medium 122 it is possible to promote life and health in transplant recipients by introducing higher levels of dissolved oxygen, slowing down cell decomposition during storage and transportation, and further increasing the probability of a successful organ transplant.
- the unique qualities of the liquids with high levels of stable dissolved gases produced in accordance with the disclosed embodiment make it possible to use the solution as a drug delivery device.
- Medicinal compounds such as peptides, as growth factors, anti-cancer agents, etc., antibiotics or any other suitable drugs may be introduced using the solution.
- FIG. 13 shows a system for the delivery of intravenous fluids including medicines, plasma, or saline solution into a patient.
- the system 130 comprises at least one intravenous solution bag 132 filled with an oxygenated saline solution or plasma 133 and optionally various medications in solution 134 .
- the medications in solution 134 may also be oxygenated in accordance with the present invention.
- the oxygenated solutions 133 and 134 may be mixed together at a single valve 135 and directed to an infusion pump 136 to be dispensed intravenously to the arm of the patient 138 .
- oxygenate a plasma for use in the human body or other animals and that this may have application in the treatment of all forms of cancer or other medical diseases and anomalies. It is may be useful to oxygenate plasma to preserve it in useful condition when stored for extended periods of time. Additionally, it is possible to oxygenate other intravenous solutions which are to be injected via a needle or plasma into the human body. These oxygenated medicines, serums, drugs or other liquids may be used to treat all forms of cancer and other medical diseases and anomalies. It is also believed that by using oxygenated saline solutions, plasmas, or other medicines it is possible to increase the amount of oxygen that reaches living tissues and to speed the healing process.
- FIG. 14 illustrates a system using hydrotherapy or other topical applications for introducing oxygenated solutions to the body.
- the system 140 comprises a tub 142 or whirlpool bath which may be filled with oxygenated solution 144 .
- the patient 146 is either partially or wholly immersed in the oxygenated solution for topical treatment of various maladies. It is believed that using hydrotherapy or topical application of oxygenated solution it is possible for the patient to receive an increased blood oxygen level and should hopefully lead to a healthier, better feeling patient with increased energy and vitality.
- FIG. 15 illustrates an alternative embodiment of a pump and diffuser system constructed in accordance with the present invention.
- the system 150 comprises a check valve 151 for introducing a solution to be oxygenated into the system.
- the solution passes though the wall of the housing 152 and into the pump chamber 153 .
- a pumping action may be achieved by using a flexible diaphragm 154 which moves up and down. As the diaphragm 154 moves outward, solution is first drawn into the pump chamber 153 by a slight suction. As the diaphragm is drawn inward, solution is pushed upward and through an second check valve mechanism 155 .
- This valve mechanism 155 may be a selectively permeable polymer membrane, as shown here.
- the polymer membrane may be a liquid crystalline material that is activated by passing an electrical current.
- Aerated water produced in accordance with the disclosed embodiment may also be used to decontaminate or wash away contaminants from a person, animal or object. Because of the higher levels of oxygen in the water, some contaminants can be more thoroughly cleaned away by the aerated water, while providing high levels of oxygen to the surface being cleaned, which may be particularly therapeutic where the surface is an organic surface such as the eye. With reference to FIG. 22 , an eyewash station 258 using aerated water may be used to cleanse a contaminated eye 206 .
Abstract
A system and method for generating an oxygen enriched aqueous solution for therapeutic application includes a diffuser comprising a first diffusing member having a surface incorporating surface disturbances, and a second diffusing member positioned relative to the first diffusing member to form a channel through which an aqueous solution and oxygen gas may flow. A reservoir containing the aqueous solution is connected to a pump that draws the aqueous solution from the reservoir and inputs the aqueous solution into the diffuser. The aqueous solution is moved through the channel relative to the surface disturbances to create cavitation in the aqueous solution to diffuse the oxygen gas into the aqueous solution to produce an oxygen enriched aqueous solution.
Description
- This application claims priority to provisional patent application Ser. No. 60/483,422 filed Jun. 27, 2003.
- This application is a Continuation of pending U.S. patent application Ser. No. 10/877,106, filed Jun. 25, 2004, now U.S. Pat. No. 7,654,728, entitled “SYSTEM AND METHOD FOR THERAPEUTIC APPLICATION OF DISSOLVED OXYGEN,” which is a Continuation-In-Part of pending U.S. patent application Ser. No. 10/796,583, filed Mar. 9, 2004, now U.S. Pat. No. 6,974,546, entitled “DIFFUSER/EMULSIFIER FOR USE IN AQUACULTURE APPLICATIONS,” which is a Continuation of U.S. patent application Ser. No. 10/213,499, filed Aug. 6, 2002, now U.S. Pat. No. 6,702,949, entitled “DIFFUSER/EMULSIFIER FOR AQUACULTURE APPLICATIONS,” which is a Continuation-in-Part of U.S. patent application Ser. No. 10/123,004, filed Apr. 15, 2002, entitled “DIFFUSER/EMULSIFIER,” which is a Continuation of U.S. patent application Ser. No. 08/957,530, filed Oct. 24, 1997, entitled “DIFFUSER/EMULSIFIER,” now U.S. Pat. No. 6,386,751.
- This invention relates in general to diffusers and, more particularly, to a method and apparatus for diffusing or emulsifying a gas or liquid into a material.
- This invention relates in general to diffusers and, more particularly, to a method and apparatus for diffusing or emulsifying a gas or liquid into a material.
- The oxygen available in water or other liquids often has a therapeutic value. For example, eyes have a minimum necessary oxygen requirement. The continued presence of oxygen on the eye can be difficult to maintain when wearing contact lenses, particularly when contacts are worn during sleep when the eyes are closed. With typical contact lenses, oxygen passes through the water in the lens. There is a limit to the amount of water that can be used in any contact lens material and this, in turn, limits the amount of oxygen that can get to the eye. The oxygen content of the water used in the manufacture, storage, cleaning and wetting of contact lenses is an important factor in their manufacture and use. In particular, a contact lens wearer's ocular tissue can be damaged by a lack of oxygen. Contact lenses are designed in order to maximize the amount of oxygen reaching the cornea, keeping the eyes fresh and healthy all day long
- In many applications, it is necessary to diffuse or emulsify one material—gas or liquid—within a second material. Emulsification is a subset of the process of diffusion wherein small globules of one liquid are suspended in a second liquid with which the first will not mix, such as oil into vinegar. One important application of the diffusion process is in wastewater treatment. Many municipalities aerate their wastewater as part of the treatment process in order to stimulate biological degradation of organic matter. The rate of biological digestion of organic matter is very dependent upon the amount of oxygen in the wastewater, since the oxygen is necessary to sustain the life of the microorganisms which consume the organic matter. Additionally, oxygen is able to remove some compounds, such as iron, magnesium and carbon dioxide.
- There are several methods of oxygenating water. First, turbine aeration systems release air near the rotating blades of an impeller which mixes the air or oxygen with the water. Second, water can be sprayed into the air to increase its oxygen content. Third, a system produced by AQUATEX injects air or oxygen into the water and subjects the water/gas to a large scale vortex. Tests on the AQUATEX device have shown an improvement to 200% dissolved oxygen (approximately 20 ppm (parts per million)) under ideal conditions Naturally occurring levels of oxygen in water are approximately 10 ppm maximum, which is considered to be a level of 100% dissolved oxygen. Thus, the AQUATEX device doubles the oxygen content of the water. The increased oxygenation levels last only minutes prior to reverting back to 100% dissolved oxygen levels.
- Greater oxygenation levels, and longer persistence of the increased oxygen levels, could provide significant benefits in treating wastewater. Importantly, the efficiency of the organic digestion would be increased and the amount of time need for biological remediation would decrease, improving on the capacity of wastewater treatment facilities.
- Accordingly, a need has arisen for a diffusing mechanism capable of diffusing high levels of one or more materials into another material.
- A system and method for generating an oxygen enriched aqueous solution for therapeutic application includes a diffuser comprising a first diffusing member having a surface incorporating surface disturbances, and a second diffusing member positioned relative to the first diffusing member to form a channel through which an aqueous solution and oxygen gas may flow. A reservoir containing the aqueous solution is connected to a pump that draws the aqueous solution from the reservoir and inputs the aqueous solution into the diffuser. The aqueous solution is moved through the channel relative to the surface disturbances to create cavitation in the aqueous solution to diffuse the oxygen gas into the aqueous solution to produce an oxygen enriched aqueous solution.
- For a more complete understanding of the present invention, and the advantages thereof, reference is now made to the following descriptions taken in conjunction with the accompanying drawings, in which:
-
FIGS. 1 and 1 a illustrate a partially cross sectional, partially block diagram of a first embodiment of a diffuser; -
FIGS. 2 a, 2 b and 2 c illustrate the diffusion process internal to the diffuser; -
FIG. 3 illustrates an exploded view of the rotor and stator of the diffuser; -
FIG. 4 illustrates an embodiment of the stator; -
FIG. 5 a illustrates a cross-section view of the rotor-stator assembly in a second embodiment of the invention; -
FIG. 5 b illustrates a top view of the rotor in the second embodiment of the invention; -
FIG. 6 illustrates a cut-away view of a third embodiment of the invention; - 7 a through 7 h illustrate alternative embodiments for generating the diffusion;
-
FIGS. 8 a and 8 b illustrate another alternative embodiment of the invention; -
FIG. 9 illustrates a schematic drawing of a method for producing oxygenated solutions using a diffuser in accordance with the present invention; -
FIGS. 10 a through 10 c illustrate an oxygenated solution and its application to the eye as drops or as contact lens solution; -
FIG. 11 illustrates the storage and transportation of organs or living tissues in a container filled with oxygenated solution. -
FIG. 12 illustrates the storage and transportation of organs or living tissue using a system having a container of oxygenated solution and having a portable pump and diffuser recirculation system; -
FIG. 13 illustrates the delivery of oxygenated medicine, plasma, or other intravenous fluid to a patient; -
FIG. 14 illustrates the use of oxygenated solution in hydrotherapy or other topical application to a patient; -
FIG. 15 illustrates an alternative embodiment of a pump and diffuser system constructed in accordance with a disclosed embodiment -
FIG. 16 illustrates a simplified nanocage; -
FIG. 17 illustrates an eye; -
FIG. 18 illustrates a cut-away view of a contact lens; -
FIG. 19 illustrates a spin-cast process for forming a contact lens; -
FIG. 20 illustrates a lathe cutting process for forming a contact lens; -
FIG. 21 illustrates a mold casting process for forming a contact lens; and -
FIG. 22 illustrates an eyewash station. - Referring now to the drawings, wherein like reference numbers are used to designate like elements throughout the various views, several embodiments of the present invention are further described. The figures are not necessarily drawn to scale, and in some instances the drawings have been exaggerated or simplified for illustrative purposes only. One of ordinary skill in the art will appreciate the many possible applications and variations of the present invention based on the following examples of possible embodiments of the present invention.
- The present invention is best understood in relation to
FIGS. 1-8 of the drawings, like numerals being used for like elements of the various drawings. -
FIGS. 1 and 1 a illustrate a partially block diagram, partially cross-sectional view first embodiment of adevice 10 capable of diffusing or emulsifying one or two gaseous or liquid materials (hereinafter the “infusion materials”) into another gaseous or liquid material (hereinafter the “host material”). The host material may be a normally solid material which is heated or otherwise processed to be in a liquid or gaseous state during the diffusion/emulsification process. - A
rotor 12 comprises a hollow cylinder, generally closed at both ends.Shaft 14 andinlet 16 are coupled to the ends of therotor 12. A first infusion material can pass throughinlet 16 into the interior ofrotor 12.Shaft 14 is coupled to amotor 18, which rotates the rotor at a desired speed. Therotor 12 has a plurality ofopenings 22 formed there through, shown in greater detail inFIG. 1 a. In the preferred embodiment, theopenings 22 each have anarrow orifice 24 and alarger borehole 26. Thesidewalls 28 of theboreholes 26 can assume various shapes including straight (as shown inFIG. 4 ), angled (as shown inFIG. 1 ) or curved. - A
stator 30 encompasses therotor 12, leaving achannel 32 between the rotor and the stator through which the host material may flow. Thestator 30 also hasopenings 22 formed about its circumference. Ahousing 34 surrounds thestator 30 andinlet 36 passes a second infusion material to anarea 35 between thestator 30 and thehousing 34. The host material passes throughinlet 37 into thechannel 32.Seals 38 are formed between theshafts housing 34. Anoutlet 40 passes the host material from thechannel 32 to apump 42, where it exits viapump outlet 44. The pump may also be driven bymotor 18 or by an auxiliary source. - In operation, the diffusion device receives the host material through
inlet 37. In the preferred embodiment, pump 42 draws the host material on the pump's suction side in order to allow the host material to pass through the channel at low pressures. The first and second infusion materials are introduced to the host material throughopenings 22. The infusion materials may be pressurized at their source to prevent the host material from passing throughopenings 22. - The embodiment shown in
FIG. 1 has separate inlets for 16 and 36 for the diffusion materials. This arrangement allows two different infusion materials to be introduced to the host material. Alternatively, a single infusion material could be introduced into both inlets. - In tests, the embodiment shown in
FIG. 1 has demonstrated high levels of diffusion of the infusion material(s) into the host material. Tests using oxygen as the infusion material and water as the host material have resulted in levels of 400% dissolved oxygen in the water, with the increased oxygen levels lasting for days. - The reason for the high efficiency and persistence of the diffusion is believed to be the result of micro-cavitation, which is described in connection with
FIGS. 2 a-c. Whenever a material flows over a smooth surface, a rather laminar flow is established with a thin boundary layer that is stationary or moving very slowly because of the surface tension between the moving fluid and the stationary surface. Theopenings 22, however, disrupt the laminar flow and can cause compression and decompression of the material. If the pressure during the decompression cycle is low enough, voids (cavitation bubbles) will form in the material. The cavitation bubbles generate arotary flow pattern 46, like a tornado, because the localized area of low pressure draws the host material and the infusion material, as shown inFIG. 2 a. When the cavitation bubbles implode, extremely high pressures result. As two aligned openings pass one another, a succussion (shock wave) occurs, generating significant energy. The energy associated with cavitation and succussion mixes the infusion material and the host material to an extremely high degree, perhaps at the molecular level. - The tangential velocity of the
rotor 12 and the number of openings that pass each other per rotation dictate the frequency at which the device operates. It has been found that operation in the ultrasonic frequency can be beneficial in many applications. It is believed that operating the device in the ultrasonic region of frequencies provides the maximum succussion shock energy to shift the bonding angle of the fluid molecule, which enables it to transport additional infusion materials which it would not normally be able to retain. The frequency at which the diffuser operates appears to affect the degree of diffusion, leading to much longer persistence of the infusion material in the host material. - In some applications, a particular frequency or frequencies may be desired to break down certain complex molecules, such as in the case of water purification. In this application, multiple frequencies of succussion can be used to break complex structures, such as VOCs (volatile organic compounds), into smaller sub-structures. Ozone can be used as one of the infusion materials to oxidize the sub-structures at a high efficiency.
- Other sonochemistry applications can be performed with the
device 10. In general, sonochemistry uses ultrasound to assist chemical reactions. Typically, the ultrasound is generated using a piezoelectric or other electro-acoustical device. A problem associated with electro-acoustical transducers is that the sound waves do not provide uniform sound waves throughout the material; rather, the desired cavitation is localized around the device itself The present invention allows the ultrasonic waves to be produced throughout a material using a simple mechanical device. -
FIG. 3 illustrates an exploded view of an embodiment of therotor 12 andstator 30 where multiple frequencies may be obtained at a single rotational velocity. InFIG. 3 , three circular arrays of openings 50 (shown individually asarrays openings 22 are disposed circumferentially about therotor 12. Each ring has a different number of openings evenly spaced about its circumference. In similar fashion, thestator 30 would have three circular arrays of openings 52 (shown individually asarrays openings 22 in a given array 52 on thestator 30 can be one more (or less) than the number ofopenings 22 in thecorresponding array 50 of therotor 12. Thus, for example, ifarray 50 a had twenty openings evenly spaced around the circumference ofrotor 12, array 52 could have 21 openings spaced evenly around the circumference ofstator 30. - As the
rotor 12 ofFIG. 3 rotates relative tostator 30, each array will create succussions at a different frequency. By properly choosing different frequencies, a sum and difference interference pattern will result, creating a wide spectrum of frequencies. This spectrum of frequencies can be beneficial in many applications where unknown impurities in a host liquid need to be broken down and oxidized. -
FIG. 4 illustrates a cross-sectional side view of an embodiment of astator 30. For smaller diameter stators, it may be difficult to form theborehole 26 on the inside ofstator 30. The embodiment ofFIG. 4 uses aninner sleeve 54 and anouter sleeve 56. Theboreholes 26 can be drilled, from the outside, of theinner sleeve 54. For each borehole 26 on theinner sleeve 54, a corresponding alignedorifice 24 is drilled on theouter sleeve 56. Theinner sleeve 54 is then placed in, and secured to, theouter sleeve 56 to form thestator 30. Other methods, such as casting, could also be used to form thestator 30. -
FIGS. 5 a-b and 6 illustrate alternative embodiments of thediffuser 10. Where appropriate, reference numerals fromFIG. 1 are repeated in these figures. -
FIG. 5 a illustrates an cross-sectional side view of an embodiment where therotor 12 andstator 30 are disk shaped.FIG. 5 b illustrates a top view of the disk shapedrotor 12. Thestator 30 is formed above and below therotor 12. Both thestator 12 androtor 30 have a plurality of openings of the type described in connection withFIG. 1 , which pass by each other as therotor 12 is driven by the motor. As before, for each array 52, thestator 30 may have one opening more or less than thecorresponding array 50 inrotor 12 in order to prevent simultaneous succussion at two openings within an array. Theopenings 22 can be of the same shape as shown inFIG. 1 . A hollow shaft serves as theinlet 16 to the interior of the disk shaped rotor for the first infusion material. Similarly, anarea 35 between thestator 30 and thehousing 34 receives the second infusion material. As the host material flows in thechannel 32 between therotor 12 and thestator 30, it is subjected to the vortex generation at theopenings 22, thereby causing a diffusion of the first and second materials with the host material. The infused host material passes tooutlets 40. -
FIG. 5 b illustrates a top view of therotor 12. As can be seen, a plurality of openings forms concentric arrays of openings on therotor 12. Each array can, if desired, generate secussions at different frequencies. In the preferred embodiment,openings 22 would be formed on the top and bottom of therotor 12. Corresponding openings would be formed above and below these openings on thestator 30. -
FIG. 6 illustrates a cut away view of an embodiment of the invention where therotor 12 has a conical shape. Both thestator 12 androtor 30 have a plurality of openings of the type described in connection withFIG. 1 , which pass by each other as therotor 12 is driven by the motor. In addition to the openings around the circumference of therotor 12, there could also be openings at the bottom of the conical shape, with corresponding openings in the portion of thestator 30 at the bottom. As before, for each array, thestator 30 may have one opening more or less than therotor 12 in order to prevent simultaneous succussion at twoopenings 22 on the same array. A hollow shaft serves as theinlet 16 to the interior of the disk shaped rotor for the first infusion material. Similarly, anarea 35 between thestator 30 and thehousing 34 receives the second infusion material. As the host material flows between therotor 12 and thestator 30, it is subjected to the vortex generation at theopenings 22, thereby causing a diffusion of the first and second materials with the host material. The infused host material passes tooutlets 40. - In the embodiments of
FIGS. 5 a-b and 6, because the arrays ofopenings 22 can be formed at increasing diameters, generation of multiple frequencies may be facilitated. It should be noted that any number of shapes could be used, including hemi-spherical and spherical shapes to realize therotor 12 andstator 30. - The diffuser described herein can be used in a number of applications. Optimal opening size (for both the
orifice 24 and borehole 26), width ofchannel 32, rotational speed and rotor/stator diameters may be dependent upon the application of the device. - As described above, the
diffuser 10 may be used for water aeration. In this embodiment air or oxygen is used as both the first and second infusion materials. The air/oxygen is diffused into the wastewater (or other water needing aeration) as described in connection withFIG. 1 . It has been found that the diffuser can increase the oxygenation to approximately 400% dissolved oxygen, with greater concentrations expected as parameters are optimized for this application. In tests which circulated approximately twenty five gallons of municipal water at ambient temperatures (initially having a reading of 84.4% dissolved oxygen) through the device for five minutes to achieve 390% dissolved oxygen content, the enhanced concentration of oxygen levels remained above 300% dissolved oxygen for a period of four hours and above 200% dissolved oxygen for over 19 hours. After three days, the dissolved oxygen content remained above 134%. In these tests, frequencies of 169 kHz were used. The sizes of the openings were 0.030 inches for theorifice 24 and 0.25 inches for the borehole (with theboreholes 26 on the rotor having sloped sides). Cooler temperatures could significantly increase the oxygenation levels and the persistence. - Also for the treatment of wastewater, or for bio-remediation of other toxic materials, oxygen could be used as one of the infusion materials and ozone could be used as the other infusion material. In this case, the ozone would be used to oxidize hazardous structures in the host material, such as VOCs and dangerous microorganism. Further, as described above, a set of frequencies (as determined by the arrays of openings in the
rotor 12 and stator 30) could be used to provide an destructive interference pattern which would break down many of the complex structures into smaller substructures. Alternatively, if the treatment was directed towards oxidation of a single known hazardous substance, it would be possible to use a single frequency which was known to successfully break down the structure. Conversely, a set of frequencies which result in a constructive interference pattern could be used to combine two or more compounds into a more complex and highly structured substance. - For producing potable water, ozone could be used as the first and second infusion material to break down and oxidize contaminants.
- While the operation of the
diffuser 10 has been discussed in connection with large applications, such as municipal wastewater remediation, it could also be used in household applications, such as drinking water purifiers, swimming pools and aquariums. - The diffuser could also be used for other applications where diffusion of a gas or liquid into another liquid changes the characteristics of the host material. Examples of such applications would include the homogenization of milk or the hydrogenation of oils. Other applications could include higher efficiencies in mixing fuel and gases/liquids resulting in higher fuel economy.
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FIGS. 7 a-b illustrate alternative embodiments for therotor 12 andstator 30. InFIG. 7 a, the “stator” 30 also rotates; in this case, the frequency of the succussions will be dependent upon the relative rotational speed between therotor 12 andstator 30. InFIG. 7 b, one of either therotor 12 orstator 30 does not pass an infusion material through the component (inFIG. 7 b only the rotor passes an infusion material); the component which does not pass an infusion material has itsopenings 22 replaced bycavities 58 to produce the turbulence. Thecavities 58 could be shaped similarly to theboreholes 26 without the accompanyingorifices 24. - In
FIG. 7 c, theorifice 24 through which the infusion material is passed through therotor 12 orstator 30 is positioned next to theborehole 26, rather than in the borehole 26 as in previous embodiments. It should be noted that the primary purpose of theborehole 26 is to disrupt the laminar flow of the host material along the surface of therotor 12 andstator 30. The compression and rarefaction (decompression) of the host material causes the micro-cavitation, which provides the high degree of diffusion produced by the device. During decompression, voids (cavitation bubbles) are produced in the host material. The cavitation bubbles grow and contract (or implode) subject to the stresses induced by the frequencies of the succussions. Implosions of cavitation bubbles produce the energy which contribute to the high degree of diffusion of the infusion materials into the host material as it passes through thechannel 32. Thus, so long as the infusion materials and the host material are mixed at the point where the cavitation and resultant shock waves are occurring, the diffusion described above will result. -
FIG. 7 d illustrates an embodiment where the initial mixing of the host material and one or more infusion materials is performed outside ofchannel 32. In this embodiment a Mazzie diffuser 60 (or other device) is used to perform the initial mixing of the infusion material(s) and the host material. The mixture is input into thechannel 32 between therotor 12 andstator 30, wherein undergoes the compression/rarefaction cycles discussed above, which cause cavitation in the mixture, and is subjected to the frequency of the shock waves. - Further, the generation of the cavitation and shock waves could be performed using structures which differ from the
boreholes 26 shown in the embodiments above. As stated above, theboreholes 26 are surface disturbances which impede the laminar flow of the host material along the sidewalls of thechannel 32. InFIG. 7 e, a protrusion, such asbump 62 could be used as a surface disturbance in place of or in conjunction with theboreholes 26. Shapes other than rounded shapes could also be used. As shown inFIG. 7 f, grooves (or ridges) 64 could be formed in therotor 12 and/orstator 30 to generate the cavitation and shock waves. - As stated above, not all applications require, or benefit from, the generation of shock waves at a particular frequency. Therefore, the
rotor 12 orstator 30 could have the boreholes 26 (or other surface disturbances) arranged such that a white noise was produced, rather than a particular frequency. The structures used to create the cavitation need not be uniform; a sufficiently rough surface be formed on therotor 12 orstator 30 will cause the cavitation. Additionally, as shown inFIG. 7 g, it may not be necessary for both the surface of therotor 12 and the surface of thestator 30 to create the cavitation; however, in most cases, operation of thedevice 10 will be more efficient if both surfaces are used. -
FIG. 7 h illustrates a embodiment where the movement which causes the cavitation is provided by the host material (optionally with entrained infused material) rather than by relative motion of therotor 12 andstator 30. In the embodiment ofFIG. 7 h, thechannel 32 is formed between twowalls 66 which are static relative to one another, one or both of which have surface disturbances facing thechannel 32. The host material is driven through the channel at high speed using a pump or other device for creating a high speed flow. One or more infusion materials are input into the channel, either throughorifices 24 or by mixing the host material with the infusion materials external to the channel. The high speed of the host material relative to thewalls 66 causes the micro-cavitation and succussions described above. - As an example, one or more of the
walls 66 could be a fine mesh, through which the infusion material(s) flows to mix with the host material in thechannel 32. The surface disturbances in the mesh would cause micro-cavitations and succussions as the host material flows over the mesh at high speed. The frequency of the succussions would depend upon the resolution of the mesh and the speed of the host material. Once again, the infusion materials would diffuse into the host material at the molecular level at the micro-cavitation sites. -
FIGS. 8 a and 8 b illustrate another embodiment, where a rotatingmember 70 is disposed within aconduit 72 and rotated bymotor 73. The host material and infusion material(s) are mixed in theconduit 72 upstream from the rotatingmember 70 using a Mazzie diffuser 74 or other device. The rotating member could be, for example, propeller or auger shaped. On the surface of the rotatingmember 70 has one ormore surface disturbances 76, such that the rotation of the rotatingmember 70 creates the micro cavitation discussed above, thereby causing a high degree of diffusion between the materials. The shape of the propeller blades and pattern of thesurface disturbances 76 thereon could create the cavitation and succussion at a desired frequency for purposes described above. Further, the shape of the rotating device could draw the materials through the conduit. - The present invention provides significant advantages over the prior art. First, the micro-cavitations generated by the device allow diffusion to occur at a molecular level, increasing the amount of infusion material which will be held by the host material and the persistence of the diffusion. Second, the micro-cavitations and shock waves can be produced by a relatively simple mechanical device. Third, the frequency or frequencies of the shock wave produced by the device can be used in many applications, either to break down complex structures or to aid in combining structures. Fourth, the cavitations and shock waves can be produced uniformly throughout a material for consistent diffusion.
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FIG. 9 illustrates a schematic representation of a method for producing oxygenated solutions using a diffuser constructed in accordance with the present invention. As shown here, theoxygenation system 90 comprises a supply orreservoir 91 of solution which is drawn up and circulated through tubing or other conduits by apump 92 which subsequently delivers the solution to thediffuser 95. Thediffuser 95 may be of any number of various embodiments including those set forth and described herein above in regard toFIGS. 1 through 8 b. These diffusers significantly increase the amount of dissolved oxygen (DO) present in a solution by introducing gaseous oxygen to the solution using a diffuser having coaxial cylindrical or frusto conical stator and rotor components rotating discs or plates within a housing, Mazzie diffusers and impellers to create the desired cavitation and succussion desired for mixing of the solution and the gas. It should be noted that many of the solutions will be aqueous or water-based, but that the present invention is not limited to these solutions and is believed to work with other liquid mediums as well. - The
diffuser 95 is supplied with solution by thepump 92 and combines this with gaseous oxygen fromsupply 94 and returns the oxygenated solution to thereservoir 91. Thediffuser 95 may employ any number of possible embodiments for achieving diffusion including, but not limited to, micro-membrane, Mazzi injector, fine bubble, vortexing, electromolecular activation, or other methods known in the art. Theoxygen supply 94 may be either a cylinder of compressed oxygen gas or a system for generating oxygen gas from the air or other chemical components. The oxygenated solution produced by thediffuser 95 is returned to thereservoir 91 and may be recirculated through thepump 92 and thediffuser 95 again to further attempt to increase the dissolved oxygen content or may be drawn off using the oxygenatedsolution outlet 97. Oxygenated solutions which are drawn off through theoutlet 97 may be immediately put to use in various applications or alternatively may be packaged for later use. - The
packaging step 98 may enclose oxygenated solutions in a variety of bottles, bags or other containers formed of plastic, metal, glass, or other suitable materials. Although the oxygenated solutions produced in accordance with the present invention have a relatively long shelf life under atmospheric conditions, the shelf life may be further extended by using packaging which hermetically seals the oxygenated solution. In this manner, dissolved oxygen which works its way out of the solution during storage will form a pressure head above the oxygenated solution and help to prevent the migration of dissolved oxygen out of the solution and back into the atmosphere. In one preferred embodiment of the present invention the oxygenated solution is packaged in an air tight container and the void space is filled with nitrogen or other inert gas at a pressure of greater than one atmosphere prior to sealing the container. Thepackaging step 98 may be used to produce bottles, bags, pouches, or other suitable containers for holding oxygenated solutions. - Using a diffusion system in accordance with the present invention it is possible to significantly increase the amount of dissolved gas in most liquids. The system and method allows oxygen to be dissolved stably at a high concentration with minimal passive loss. This system and method can be effectively used to dissolve a wide variety of gases at heightened percentages into a wide variety of liquids. By way of example only, a de-ionized water at room temperature that typcially has levels of about 2-3 ppm (parts per million) of dissolved oxygen can achieve levels of dissolved oxygen ranging from about 8-70 ppm using the disclosed system and method. In accordance with a disclosed embodiment, an oxygenated water solution may be generated with levels of about 30-60 ppm of dissolved oxygen.
- With reference to
FIG. 16 , a simplified protonated water cluster forming ananoscale cage 200 is shown. A protonated water cluster typically takes the form of H+ (H20)n. Some protonated water clusters occur naturally, such as in the ionosphere. As a result of the disclosed processes, OH+ molecules 202 bind to form ananocage 200.Oxygen atoms 204 may be caught in the resultingnanocage 200. The chemistry of the semi-bound nanocage allows theoxygen 204 to remain dissolved for extended periods of time, far in excess of the natural evaporation rate of oxygen is unprocessed water. The process seems to produce large-scale protonated water clusters which formnanoscale cages 200 associated with the unique chain length of the hydrogen bond network of n=21 chain length. Under these geometric conditions, all the dangling —OH groups 202 arise from water molecules in similar binding sites forming a nano-cage 200. In this cage,oxygen 204 can be stably placed so that it does not passively diffuse out readily, even after storage periods as long as a year. - Other atoms or molecules, such as medicinal compounds, can be caged for sustained delivery purposes. The specific chemistry of the solution material and dissolved compounds depend on the interactions of those materials.
- Oxygen is known or purported to have a wide variety of therapeutic and medicinal benefits. Among these benefits are faster healing and cell regrowth, improved resistance to disease, and increased energy or vitality. Increasing the level of dissolved oxygen in a liquid may increase the therapeutic and medicinal benefits of the liquid. These oxygenated liquids may be ingested, applied topically, injected or used in medicinal or therapeutic equipment or processes.
- Other gases having therapeutic or medicinal benefits may similarly be dissolved at heightened levels into liquids to increase the therapeutic and medicinal benefits of the liquid. The synergy of a heightened level of a gas in a liquid may provide therapeutic or medicinal qualities.
- With reference to
FIG. 17 , aneye 206, particularly a human eye, is shown. Light is admitted through thepupil 210. Thecornea 208 is the transparent gel-like coating of theeye 206 which covers thepupil 210 andiris 109.Tear ducts 212 at the corner of theeye 206 provide tears to continually moisten thecornea 208. People use contact lenses to correct refractive disorders of theeye 206 such as myopia, hyperopia and astigmatism. Lack of oxygen available to thecornea 206, which is covered by the contact lens can be major source of trouble for contact-lens wearers. - An oxygen-rich solution may be used to formulate an eye-drop that patients can use daily to optimize contact lens wear and thereby provide enhanced levels of oxygen to the contact-lens covered
cornea 208. The aerated water produced in accordance with the disclosed systems and methods may be used in the manufacture, storage or care of contact lenses. Heightened levels of dissolved gas may increase the potency or safety of solutions used to store, clean, or moisten contact lenses. - The introduction and retention of oxygen to the contact lens material in the manufacture and use of contact lens manufacture and use. Because of the enriched dissolved oxygen content of the aerated water produced in accordance with the disclosed methods, the dissolved oxygen content of the contact lenses themselves as well as solutions used with contact lenses may enhanced. Saline solutions and other contact lens storage and wetting solutions may be produced using the aerated water.
- With reference to
FIG. 18 , a half-side cut-away view of acontact lens 214 is shown.Contact lenses 214 are typically formed of soft polymer substances and may generally be divided into the categories of hydrophilic and hydrophobic lenses.Hydrophilic contact lenses 214 have a water content in excess of ten percent while hydrophobic lenses have water content of less than ten percent. The oxygen permeability of acontact lens 214 depends largely on the specific polymer used to form the lens. The oxygen permeability may be increased by using an aerated water to hydrate the polymer when the lens is created. Contact lenses may be made from a variety of commercially available materials, such as hydrophilic polymers (e.g., hydrogels) or poly(methyl methacrylate). A typical hydrogel polymer composition may consist of a reaction product of hydrophilic methacrylamide as well as an acrylic monomer, which may contain a zwitterionic monomer, such as a sulfobetaine, for example, N-(3-sulfopropyl)-N-methacryloxyethyl-N,N-dimethylammonium betaine (SPE), in order to improve the water-retention capability - The
contact lens 214 has a generally dome shape in its entirety. Acontact lens 214 is typically worn on acornea 208 of a lens wearer with itsback surface 218 held in contact with a surface of thecornea 208 via tear fluid, as is well known in the art. Thecontact lens 214 has acenter axis 222 approximately aligned with an optical axis of the lens, and is shaped as a solid of revolution about thecenter axis 222. For the sake of this geometrical feature of thecontact lens 214,FIG. 18 shows only a symmetrical half of thecontact lens 214 in its diametrical cross section. - More specifically described, the
contact lens 214 includes afront surface 216 and theback surface 218. A central portion of thefront surface 216 serves as a front optical zone, while a central portion of theback surface 218 serves as a back optical zone. These front and back optical zones have circular shapes in a plane view or as seen in a direction of theoptical axis 222, and cooperate with each other to form an optical zone provided with a suitable degree of dioptric power for vision correction. These circular front and back optical zones have centers located on thecenter axis 222, and have different diameters. - With reference to
FIG. 19 , a spin casting contactlens production process 224 including aerated water produced in accordance with the disclosed methods is shown.Liquid monomer 228 is injected into a spinningmold 226 to create the acontact lens 230 with a desired lens shape, thickness and size. Themonomer 228 is distributed along themold 226 according to centrifugal force, gravity and surface tension of the liquid 228. Slower rotations produce smaller diameters, thicker centers, flatter base curves and plus powers. The opposite is true for faster rotations. When thecontact lens 230 with the desired lens parameters are obtained,UV light 232 is used to polymerize themonomer 228 into a solid lens 280. Thelens 230 is then hydrated in a solution ofoxygenated water 236 to its final state. By using anaerated water 236 produced in accordance with the disclosed methods for the hydration process, acontact lens 230 with an increased oxygen permeability can be formed. - With reference to
FIG. 20 , a lathe cutting contact lens production process including aerated water produced in accordance with the disclosed methods is shown. A polymerizedsoft lens material 238 in the rigid state is cut into the desired contact lens shape using alathe 240. After cutting, thecontact lens 242 is polished using apolishing tool 241 or chemical process. Thepolished contact lens 242 is then hydrated in a oxygenatedhydrating solution 244 to create the finalsoft contact lens 242. The finalsoft contact lens 242 is hydrated withaerated water 244 to a specific water content, where the water content depends primarily on the polymer used. - With reference to
FIG. 21 , a cast molding contactlens production process 246 including aerated water produced in accordance with the disclosed methods is shown. Aliquid monomer 248 is injected between twomolds solid form 254, which is then removed from themolds aerated water 256. Another cast molding technique maintains thelens 254 in a liquid state during the hydration. This technique minimized variations in lens parameters caused by the hydration process. In accordance with another technique, an ultraviolet mask allows the monomer within a central clear zone to be polymerized. The extra monomer can be washed away. This process produces precise edges, decreasing complications caused by rough edges formed in other techniques. -
FIGS. 10 a through 10 c illustrate various applications of oxygenated solutions for use as eye drops or contact lens solution. A variety of oxygenated liquids may be used as eye drops or contact lens solutions. Typical contact lens solutions are made for rinsing, cleaning and disinfecting the contact lenses. - As shown here the oxygenated
solution 101 may be packaged in a bottle or other sealedcontainer 100 provided with a pipette oreye dropper 102 for use in various ocular applications. One such application is that of an oxygenated saline solution for use as eye drops orartificial tears 103. The moisturizing eye drops 103 may be applied directly to the eye using theeye dropper 102 and applying two or threedrops 103 per application directly to theeye 104 to alleviate dry eyes, redness, allergic reactions, and to provide additional moisture to thecorneal region 208 of the eye. - In addition to oxygenating artificial tears to further supply oxygen to the
corneal region 208 it is also possible to oxygenate other solutions such as various aqueous medications that might be applied topically to the surface of theeye 206. This may be particularly useful to patients that have recently had surgery performed on thecornea 208 or other areas of theeye 206 to improve vision (i.e., laser keratotomy, lasic, intralasic, and so forth) or to alleviate or lessen the effects of glaucoma. - It is common to prescribe various antibiotics, anti-inflammatories and pain relieving agents which are applied as drops in solution directly to the
eye 206 itself following these and other surgical procedures. By using oxygenated aqueous solutions to increase oxygen diffusion into the surface of theeye 206, it is believed that faster healing may occur and that recovery time may be reduced. - Aging
eyes 206 often become dry as a result of lowered tear production due to problems with thetear ducts 212. This problem is particularly marked in women. Seventeen percent of menopausal women us tear supplements to maintain stable vision and eye comfort. The most immediate patho-physiological problem produced by lower tear volume in these patients is the lack of dissolved oxygen from the air which has only a smaller volume to diffuse to reach the eye. Using an aerated solution with heightened levels of dissolved oxygen may be used with positive effects as a tear supplement. - Referring now to
FIG. 10 b another alternative application of an oxygenated solution in contact with the eye is shown. In addition to possible applications in the form of artificial tears or oxygenated medicines, the oxygenation process may also be applied to contact lens solutions such as saline solutions. Acontact lens 106 is normally stored in a solution to keep the semipermeable polymer membrane moist and flexible. As shown here, acontact lens 106 which has been stored in a lens solution is normally disposed just above the cornea of theeye 104. Thecontact lens 106 will normally float just above the surface of the cornea on a layer of solution which may comprise the oxygenatedsaline solution 105 in which the lens has been stored. The oxygenated saline solution should increase the amount dissolved oxygen near the cornea of the eye and should help the eye to absorb greater amounts of oxygen that is usually possible with a contact lens in place. -
FIG. 10 c illustrates the storage of a pair ofcontact lenses 109 in astorage container 108. Thestorage container 108 has a pair of shallow recesses for containing an oxygenatedcontact lens solution 107 which is used to provide a suitable storage environment for thecontact lenses 109.Contact lenses 109 are normally formed of thin polymer membranes which are semi-permeable to oxygen gas and which must be kept moist to retain their flexibility and other physical property characteristics. Thecontact lens solution 107 may be oxygenated using the disclosed processes. The solutions are typically a saline solution which is intended to mimic natural tears and which will be readily accepted by the body. However, the solution may further include various agents to help reduce the build up of proteins or other residues on the surface of the lens which may impair vision or cause some discomfort to the wearer. - Immediate application of the oxygen-rich solution is possible for enhancing biological tissue growth conditions of all cell lines, tissues and organ cultures. An oxygen-rich solution can be used in artificial blood and blood-perfusing medicinal procedures such as coronary bypass surgery and shock-trauma procedures. Similarly, oxygen-rich solutions may be used to perfuse solid organs, such as livers, kidneys, hearts, etc., in transit for transplantation and at the time of surgery. Use of oxygenated solutions produced in accordance with the disclosed embodiments may lead to longer storage time and better transplant results.
-
FIG. 11 illustrates a container and method of transporting or storing organs, organic samples, test subjects other living tissues using oxygenated solution. Thestorage system 110 comprises an oxygenatedsolution 112 which has been poured into astorage container 114 and holds a specified volume of oxygenatedstorage medium 116 containing an organ or other living tissues 118. Thecontainer 114 may be insulated or provided with a portable refrigeration unit (not shown) and may further include various impellers or other circulators for moving the oxygenated solution on and about all the surfaces of the living tissues 118 which are being stored or transported for transplantation. In this manner, it is believed that living tissues will be better preserved with less cell damage prior to transplantation. -
FIG. 12 illustrates an alternative system for storing and transporting living tissues and organs. Thesystem 120 comprises acontainer 121 holding anoxygenated storage medium 122 and livingtissues 124 which is to be stored or transported for transplantation. Thesystem 120 further comprises acirculation pump 125 which drawssolution 122 and combines the solution with oxygen gas from thesupply 126 using adiffuser 127 constructed in accordance with the present invention. The pump, diffuser, and other components of the transportation and storage system may be provided with a portable power supply in the form of one ormore batteries 128 or a hydrogen fuel cell. - By storing and transporting organs and other living
tissues 124 in anoxygenated storage medium 122, it is possible to reduce damage to cells and living tissues outside the body and to supply these tissues to transplantation candidates in a healthier condition. By using oxygenated solutions as a storage andtransportation medium 122 it is possible to promote life and health in transplant recipients by introducing higher levels of dissolved oxygen, slowing down cell decomposition during storage and transportation, and further increasing the probability of a successful organ transplant. - The unique qualities of the liquids with high levels of stable dissolved gases produced in accordance with the disclosed embodiment make it possible to use the solution as a drug delivery device. Medicinal compounds such as peptides, as growth factors, anti-cancer agents, etc., antibiotics or any other suitable drugs may be introduced using the solution.
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FIG. 13 shows a system for the delivery of intravenous fluids including medicines, plasma, or saline solution into a patient. As shown here, thesystem 130 comprises at least oneintravenous solution bag 132 filled with an oxygenated saline solution orplasma 133 and optionally various medications insolution 134. The medications insolution 134 may also be oxygenated in accordance with the present invention. The oxygenatedsolutions single valve 135 and directed to aninfusion pump 136 to be dispensed intravenously to the arm of thepatient 138. - It is possible to oxygenate a plasma for use in the human body or other animals and that this may have application in the treatment of all forms of cancer or other medical diseases and anomalies. It is may be useful to oxygenate plasma to preserve it in useful condition when stored for extended periods of time. Additionally, it is possible to oxygenate other intravenous solutions which are to be injected via a needle or plasma into the human body. These oxygenated medicines, serums, drugs or other liquids may be used to treat all forms of cancer and other medical diseases and anomalies. It is also believed that by using oxygenated saline solutions, plasmas, or other medicines it is possible to increase the amount of oxygen that reaches living tissues and to speed the healing process.
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FIG. 14 illustrates a system using hydrotherapy or other topical applications for introducing oxygenated solutions to the body. Thesystem 140 comprises atub 142 or whirlpool bath which may be filled with oxygenatedsolution 144. In one embodiment thepatient 146 is either partially or wholly immersed in the oxygenated solution for topical treatment of various maladies. It is believed that using hydrotherapy or topical application of oxygenated solution it is possible for the patient to receive an increased blood oxygen level and should hopefully lead to a healthier, better feeling patient with increased energy and vitality. -
FIG. 15 illustrates an alternative embodiment of a pump and diffuser system constructed in accordance with the present invention. Thesystem 150 comprises acheck valve 151 for introducing a solution to be oxygenated into the system. The solution passes though the wall of thehousing 152 and into thepump chamber 153. A pumping action may be achieved by using aflexible diaphragm 154 which moves up and down. As thediaphragm 154 moves outward, solution is first drawn into thepump chamber 153 by a slight suction. As the diaphragm is drawn inward, solution is pushed upward and through an secondcheck valve mechanism 155. Thisvalve mechanism 155 may be a selectively permeable polymer membrane, as shown here. In one embodiment, the polymer membrane may be a liquid crystalline material that is activated by passing an electrical current. - As the solution is forced out of the
pump chamber 153 and through themembrane 155, it moves into a liquid filtration andaeration material 157. The filtration and aeration material is held in place by the upper portion of the housing ortop cover 158. Various gases, usually oxygen, may then be introduced into the solution through anentry port 156. After the solution has mixed with and dissolved a desired amount of gas it is then pushed out of the pump and diffuser system through theexit port 159. It is notable that this particular embodiment of the present invention may be quite compact. Accordingly, it should be possible to incorporate this devise into portable devices and into other systems requiring various solutions containing dissolved gases. - Aerated water produced in accordance with the disclosed embodiment may also be used to decontaminate or wash away contaminants from a person, animal or object. Because of the higher levels of oxygen in the water, some contaminants can be more thoroughly cleaned away by the aerated water, while providing high levels of oxygen to the surface being cleaned, which may be particularly therapeutic where the surface is an organic surface such as the eye. With reference to
FIG. 22 , aneyewash station 258 using aerated water may be used to cleanse a contaminatedeye 206. - It will be appreciated by those skilled in the art having the benefit of this disclosure that this invention provides a method and system of providing an ordered liquid with dissolved gas for therapeutic and medicinal uses. It should be understood that the drawings and detailed description herein are to be regarded in an illustrative rather than a restrictive manner, and are not intended to limit the invention to the particular forms and examples disclosed. On the contrary, the invention includes any further modifications, changes, rearrangements, substitutions, alternatives, design choices, and embodiments apparent to those of ordinary skill in the art, without departing from the spirit and scope of this invention, as defined by the following claims. Thus, it is intended that the following claims be interpreted to embrace all such further modifications, changes, rearrangements, substitutions, alternatives, design choices, and embodiments.
Claims (32)
1.-48. (canceled)
49. A stabilized aqueous gas solution or emulsion, comprising an aqueous saline solution of molecularly diffused or emulsified gas combined with water in stabilized molecular structures having enhanced persistence over at least days.
50. The stabilized aqueous gas solution or emulsion of claim 49 , wherein the stabilized molecular structures comprise gas-containing bubble structures.
51. The stabilized aqueous gas solution or emulsion of claim 49 , wherein the saline comprises physiological saline.
52. The stabilized aqueous gas solution or emulsion of claim 49 , wherein enhanced persistence comprises enhanced persistence over at least three days.
53. The stabilized aqueous gas solution or emulsion of claim 49 , wherein the gas comprises oxygen.
54. The stabilized aqueous gas solution or emulsion of claim 53 , comprising from about 8 to about 70 parts per million (ppm) oxygen, and wherein the stabilized molecular structures having enhanced persistence over at least days comprise oxygen.
55. The stabilized aqueous gas solution or emulsion of claim 53 , comprising from about 30 to about 60 parts per million (ppm) oxygen, and wherein the stabilized molecular structures having enhanced persistence over at least days comprise oxygen.
56. The stabilized aqueous gas solution or emulsion of claim 49 , wherein molecularly diffused or emulsified gas combined with water in stabilized molecular structures comprises gas that is molecularly diffused or emulsified into the saline solution by mechanical mixing and cavitation means.
57. The stabilized aqueous gas solution or emulsion of claim 56 , wherein mechanical mixing and/or cavitation means comprises at least one mechanical force selected from the group consisting of ultrasonic waves, compression, decompression, rarefaction, expansion, contraction, succession, implosion, cavitation, rotary flow, and vortex.
58. The stabilized aqueous gas solution or emulsion of claim 49 , wherein a bonding angle of the water within the stabilized molecular structures is shifted relative the respective bonding angle of water not within the stabilized molecular structures.
59. The stabilized aqueous gas solution or emulsion of claim 49 , further comprising at least one therapeutic agent or drug.
60. The stabilized aqueous gas solution or emulsion of any one of claims 49 through 59, wherein the stabilized molecular structures comprise oxygen-containing bubble structures.
61. The stabilized aqueous gas solution or emulsion of claim 49 , comprising ozone.
62. A method of therapeutically applying dissolved oxygen, comprising:
obtaining a stabilized aqueous oxygen-containing solution or emulsion, comprising an aqueous saline solution of molecularly diffused or emulsified oxygen combined with water in stabilized molecular structures having enhanced persistence over at least days; and
applying the stabilized aqueous oxygen-containing solution or emulsion topically to be absorbed through the skin, wherein a method of therapeutically applying dissolved oxygen is afforded.
63. The method of claim 62 , wherein applying comprises applying to a surface of a living tissue.
64. The method of claim 63 , wherein the living tissue is outside of a body.
65. The method of claim 64 , wherein the tissue is being transported or stored.
66. The method of claim 62 , wherein applying comprises applying to the cornea of the eye.
67. A method of stably infusing gas into aqueous saline, comprising:
obtaining an aqueous saline solution; and
infusing a gas into the saline solution using mechanical mixing and cavitation means to molecularly diffuse or emulsify the gas into the saline in the form of gas combined with water in stabilized molecular structures having enhanced persistence over at least days, wherein method of stably infusing gas into aqueous saline is afforded.
68. The method of claim 67 , wherein mechanical mixing and/or cavitation comprises at least one of ultrasonic waves, compression, decompression, rarefaction, expansion, contraction, succussion, implosion, rotary flow, and vortex.
69. The method of claim 67 , wherein cavitation comprises generation of cavitation bubbles.
70. The method of claim 67 , wherein the stabilized molecular structures comprise gas-containing bubble structures.
71. The method of claim 67 , wherein the saline comprises physiological saline.
72. The method of claim 67 , wherein enhanced persistence comprises enhanced persistence over at least three days.
73. The method of claim 67 , wherein the gas comprises oxygen.
74. The method of claim 73 , comprising infusion of from about 8 to about 70 parts per million (ppm) oxygen, and wherein the stabilized molecular structures having enhanced persistence over at least days comprise oxygen.
75. The method of claim 73 , comprising infusion of from about 30 to about 60 parts per million (ppm) oxygen, and wherein the stabilized molecular structures having enhanced persistence over at least days comprise oxygen.
76. The method of claim 67 , wherein a bonding angle of the water within the stabilized molecular structures is shifted relative the respective bonding angle of water not within the stabilized molecular structures.
77. The method of claim 67 , further comprising addition of at least one therapeutic agent or drug.
78. The method of one of claims 67 through 77, wherein the stabilized molecular structures comprise oxygen-containing bubble structures.
79. The method of claim 67 , wherein the gas comprises ozone.
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US12/697,846 US20110008462A1 (en) | 1997-10-24 | 2010-02-01 | System and method for therapeutic application of dissolved oxygen |
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US10/213,499 US6702949B2 (en) | 1997-10-24 | 2002-08-06 | Diffuser/emulsifier for aquaculture applications |
US48342203P | 2003-06-27 | 2003-06-27 | |
US10/796,583 US6974546B2 (en) | 1997-10-24 | 2004-03-09 | Diffuser/emulsifier for aquaculture applications |
US10/877,106 US7654728B2 (en) | 1997-10-24 | 2004-06-25 | System and method for therapeutic application of dissolved oxygen |
US12/697,846 US20110008462A1 (en) | 1997-10-24 | 2010-02-01 | System and method for therapeutic application of dissolved oxygen |
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US20230027441A1 (en) * | 2019-12-17 | 2023-01-26 | Kujtim HYSENI | Cavitator for gas generation |
CN110980915B (en) * | 2019-12-23 | 2022-08-02 | 解冰 | Application of nano oxygen free radical water in anticancer medicine |
Citations (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2278051A (en) * | 1940-04-11 | 1942-03-31 | American Viscose Corp | Apparatus for cutting and mixing |
US2734728A (en) * | 1956-02-14 | myers | ||
US2969960A (en) * | 1957-06-05 | 1961-01-31 | Mobay Chemical Corp | Mixing apparatus |
US2970817A (en) * | 1958-08-04 | 1961-02-07 | Mobay Chemical Corp | Mixing apparatus |
US3174185A (en) * | 1961-05-01 | 1965-03-23 | Metal Box Co Ltd | Extrusion of molten thermoplastic material |
US3630498A (en) * | 1968-07-31 | 1971-12-28 | Namco Corp | Apparatus for gasifying and degasifying a liquid |
US3791349A (en) * | 1973-01-29 | 1974-02-12 | Sonaqua Inc | Steam generator |
US3937445A (en) * | 1974-02-11 | 1976-02-10 | Vito Agosta | Process and apparatus for obtaining the emulsification of nonmiscible liquids |
US3938783A (en) * | 1970-10-30 | 1976-02-17 | The Upjohn Company | Method for continuous mixing of foam materials |
US3939073A (en) * | 1974-11-26 | 1976-02-17 | Jules Bats | Apparatus for deodorizing liquids |
US4004553A (en) * | 1974-03-25 | 1977-01-25 | Alfa-Laval Ab | Heat treating apparatus for liquids |
US4011027A (en) * | 1974-09-23 | 1977-03-08 | Escher Wyss G.M.B.H. | Stain removal apparatus |
US4014526A (en) * | 1976-04-26 | 1977-03-29 | Cramer Jr Roy A | Liquid moving and mixing apparatus |
US4069147A (en) * | 1974-09-19 | 1978-01-17 | Chemetron Corporation | Waste water treatment with oxygen |
US4071225A (en) * | 1976-03-04 | 1978-01-31 | Holl Research Corporation | Apparatus and processes for the treatment of materials by ultrasonic longitudinal pressure oscillations |
US4136971A (en) * | 1975-04-22 | 1979-01-30 | Varlamov Vladimir M | Apparatus for creating acoustic oscillations in a running liquid medium |
US4143639A (en) * | 1977-08-22 | 1979-03-13 | Frenette Eugene J | Friction heat space heater |
US4144167A (en) * | 1977-04-14 | 1979-03-13 | Burkett Albert L | Sewage treatment system |
US4183681A (en) * | 1978-05-19 | 1980-01-15 | Exxon Research & Engineering Co. | Emulsion preparation method using a packed tube emulsifier |
US4316673A (en) * | 1978-08-08 | 1982-02-23 | General Dynamics, Pomona Division | Mixing device for simultaneously dispensing two-part liquid compounds from packaging kit |
US4318429A (en) * | 1979-05-23 | 1982-03-09 | Compagnie Generale Des Etablissements Michelin | Installation for preparing a liquid or pasty mixture intended to be molded and method for the use of said installation |
US4368986A (en) * | 1980-10-06 | 1983-01-18 | Harsco Corporation | Dual shell blender with intensifier |
US4424797A (en) * | 1981-10-13 | 1984-01-10 | Eugene Perkins | Heating device |
US4436430A (en) * | 1979-05-17 | 1984-03-13 | Mayer Karl M | Device for the continuous mixing of a dry finished mortar |
US4507285A (en) * | 1982-04-10 | 1985-03-26 | Kuehne Friedrich Wilhelm | Stabilized activated oxygen and pharmaceutical compositions containing said stabilized activated oxygen |
US4633909A (en) * | 1984-04-06 | 1987-01-06 | Degremont | Apparatus for the rapid in-line mixing of two fluids |
US4634675A (en) * | 1983-12-29 | 1987-01-06 | New Brunswick Scientific Co., Inc. | Agitator for a fermentation and tissue culturing vessel |
US4645606A (en) * | 1985-04-24 | 1987-02-24 | Ashbrook Clifford L | Magnetic molecular agglomerate reducer and method |
US4733972A (en) * | 1987-07-09 | 1988-03-29 | Aqua-Aerobic Systems, Inc. | Floating mixer apparatus with foam dispersing spray |
US4798176A (en) * | 1987-08-04 | 1989-01-17 | Perkins Eugene W | Apparatus for frictionally heating liquid |
US4808007A (en) * | 1982-05-13 | 1989-02-28 | Komax Systems, Inc. | Dual viscosity mixer |
US4906574A (en) * | 1987-06-12 | 1990-03-06 | Biogal Gyogyszergyar | Fermenting device for the culture of aerobic micro-organisms |
US4908101A (en) * | 1986-11-18 | 1990-03-13 | Hedemora Ab | Method and apparatus for mixing chemicals into fiber pulp |
US5082558A (en) * | 1990-08-31 | 1992-01-21 | Burris William A | Compact contact lens purification system using ozone generator |
US5176447A (en) * | 1988-04-29 | 1993-01-05 | Energiagazdalkodasi Intenzet | Turbomixer with rotating injector for mixing liquid |
US5185081A (en) * | 1990-04-04 | 1993-02-09 | Outokumpu Oy | Method and apparatus for mixing and separating two liquid phases while preventing aeration and emulsions using a mixer-settler |
US5188090A (en) * | 1991-04-08 | 1993-02-23 | Hydro Dynamics, Inc. | Apparatus for heating fluids |
US5275486A (en) * | 1990-09-06 | 1994-01-04 | Transsonic Uberschall-Anlagen Gmbh | Device for acting upon fluids by means of a shock wave |
US5279262A (en) * | 1992-06-04 | 1994-01-18 | Muehleck Norman J | Mechanical liquid vaporizing waterbrake |
US5279463A (en) * | 1992-08-26 | 1994-01-18 | Holl Richard A | Methods and apparatus for treating materials in liquids |
US5281341A (en) * | 1991-08-09 | 1994-01-25 | Administrators Of The Tulane Educational Fund | Sludge treatment process |
US5378321A (en) * | 1992-03-04 | 1995-01-03 | Kamyr, Inc. | Varying annular fluidization zone for increased mixing efficiency in a medium consistency mixer |
US5380471A (en) * | 1991-07-31 | 1995-01-10 | Mitsubishi Denki Kabushiki Kaisha | Aeration apparatus for producing ultrapure water |
US5380089A (en) * | 1992-07-29 | 1995-01-10 | Karasawa; Yukihiko | Emulsifying apparatus for solid-liquid multiphase flow and nozzle for solid-liquid multiphase flow |
US5482369A (en) * | 1993-02-08 | 1996-01-09 | Verstallen; Adrian | Process for homogenizing essentially immiscible liquids for forming an emulsion |
US5590961A (en) * | 1992-12-16 | 1997-01-07 | Niro Holding A/S | Method for injecting a first fluid into a second fluid and an apparatus for carrying out the method |
US5711950A (en) * | 1990-01-12 | 1998-01-27 | Lorenzen; Lee H. | Process for preparing microclustered water |
US5711887A (en) * | 1995-07-31 | 1998-01-27 | Global Water Industries, Inc. | Water purification system |
US5720551A (en) * | 1994-10-28 | 1998-02-24 | Shechter; Tal | Forming emulsions |
US5863120A (en) * | 1997-01-31 | 1999-01-26 | Beloit Technologies, Inc. | Medium consistency liquid mixture |
US5865537A (en) * | 1995-10-05 | 1999-02-02 | Sulzer Chemtech Ag | Mixing device for mixing a low-viscosity fluid into a high-viscosity fluid |
US5868495A (en) * | 1991-07-08 | 1999-02-09 | Hidalgo; Oscar Mario Guagnelli | Method for treating fluent materials |
US5868944A (en) * | 1997-06-19 | 1999-02-09 | Oxygen8, Inc. | Oxygenated water cooler |
US6019499A (en) * | 1995-04-18 | 2000-02-01 | Advanced Molecular Technologies, Llc | Method of conditioning hydrocarbon liquids and an apparatus for carrying out the method |
US6173526B1 (en) * | 1998-02-10 | 2001-01-16 | Angelo L. Mazzei | Beneficiation of soil with dissolved oxygen for growing crops |
US6180059B1 (en) * | 1995-06-05 | 2001-01-30 | Therox, Inc. | Method for the preparation and delivery of gas-enriched fluids |
US6190549B1 (en) * | 1997-06-19 | 2001-02-20 | Oxygen8, Inc. | Oxygenated water cooler |
US6193786B1 (en) * | 1998-12-11 | 2001-02-27 | Pacific Gas And Electric Company | Portable oil degasification apparatus |
US6338569B1 (en) * | 1998-10-27 | 2002-01-15 | Mcgill Shane R. | Food blending apparatus |
US6344489B1 (en) * | 1991-02-14 | 2002-02-05 | Wayne State University | Stabilized gas-enriched and gas-supersaturated liquids |
US20030017001A1 (en) * | 2001-07-23 | 2003-01-23 | Ogi Jeffrey M. | Deep root watering unit |
US20030022288A1 (en) * | 1998-07-28 | 2003-01-30 | The Regents Of The University Of California | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction |
US6521248B1 (en) * | 1999-10-26 | 2003-02-18 | Bio-Hydration Research Lab, Inc. | Micro-cluster liquids and methods of making and using them |
US6524475B1 (en) * | 1999-05-25 | 2003-02-25 | Miox Corporation | Portable water disinfection system |
US20040004042A1 (en) * | 2000-09-27 | 2004-01-08 | Hadley Darrell J | Apparatus and method for increasing oxygen levels in a liquid |
US6682732B1 (en) * | 1998-08-28 | 2004-01-27 | The University Of Bath | Treatment of lesions |
US20040019319A1 (en) * | 2001-03-20 | 2004-01-29 | Derek Daw J. | Method for enriching a bodily fluid with a gas |
US20040022122A1 (en) * | 2002-08-02 | 2004-02-05 | Kozyuk Oleg V. | Devices for cavitational mixing and pumping and methods of using same |
US20040027915A1 (en) * | 2000-08-25 | 2004-02-12 | Holger Lowe | Method and statistical micromixer for mixing at least two liquids |
US6837986B2 (en) * | 2001-05-18 | 2005-01-04 | Mikuni Corporation | Device for producing electrolytic water and process for producing electrolytic water |
US20060030900A1 (en) * | 2001-07-18 | 2006-02-09 | Eckert C E | Two-phase oxygenated solution and method of use |
US20060039902A1 (en) * | 2004-08-05 | 2006-02-23 | Young Deborah A | Antagonizing interleukin-21 receptor activity |
US20060039910A1 (en) * | 2004-08-20 | 2006-02-23 | Amgen Inc. | Methods and compositions for treating allergic inflammation |
US20070003497A1 (en) * | 1999-10-26 | 2007-01-04 | Holloway William D Jr | Device and method for mixing liquids and oils or particulate solids and mixtures generated therefrom |
US20070021331A1 (en) * | 2003-06-18 | 2007-01-25 | Tranzyme Pharma Inc. | Methods of using macrocyclic modulators of the ghrelin receptor |
US7179375B2 (en) * | 1997-10-24 | 2007-02-20 | Microdiffusion, Inc. | Diffuser/emulsifier for aquaculture applications |
US7316501B2 (en) * | 2004-05-20 | 2008-01-08 | Christian Thoma | Apparatus and method for mixing dissimilar fluids |
US7334781B2 (en) * | 2004-09-13 | 2008-02-26 | Joseph Louis Donnelly | System and method for treating fuel to increase fuel efficiency in internal combustion engines |
US20080050452A1 (en) * | 2006-06-30 | 2008-02-28 | Nucryst Pharmaceuticals | Metal-containing formulations and methods of use |
US20100004189A1 (en) * | 2007-10-25 | 2010-01-07 | Revalesio Corporation | Compositions and methods for treating cystic fibrosis |
US20100003333A1 (en) * | 2008-05-01 | 2010-01-07 | Revalesio Corporation | Compositions and methods for treating digestive disorders |
US20100008997A1 (en) * | 2007-10-25 | 2010-01-14 | Revalesio Corporation | Compositions and methods for treating asthma and other lung disorders |
US20100009008A1 (en) * | 2007-10-25 | 2010-01-14 | Revalesio Corporation | Bacteriostatic or bacteriocidal compositions and methods |
US20100015235A1 (en) * | 2008-04-28 | 2010-01-21 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
US20100021464A1 (en) * | 2006-10-25 | 2010-01-28 | Revalesio Corporation | Methods of wound care and treatment |
US7654728B2 (en) * | 1997-10-24 | 2010-02-02 | Revalesio Corporation | System and method for therapeutic application of dissolved oxygen |
US20100028441A1 (en) * | 2008-04-28 | 2010-02-04 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
US20100029764A1 (en) * | 2007-10-25 | 2010-02-04 | Revalesio Corporation | Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction |
US20100028443A1 (en) * | 2007-10-25 | 2010-02-04 | Revalesio Corporation | Compositions and methods for treating inflammation |
US20100028442A1 (en) * | 2006-10-25 | 2010-02-04 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
US20100038244A1 (en) * | 2006-10-25 | 2010-02-18 | Revalesio Corporation | Mixing device |
US20120039958A1 (en) * | 2010-08-12 | 2012-02-16 | Revalesio Corporation | Compositions and methods for treatment of taupathy |
US20120039884A1 (en) * | 2010-08-13 | 2012-02-16 | Revalesio Corporation | Compositions and methods for treating cardiovascular disease |
US20120039951A1 (en) * | 2010-05-07 | 2012-02-16 | Revalesio Corporation | Compositions and methods for enhancing physiological performance and recovery time |
Family Cites Families (226)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1627161A (en) * | 1922-02-23 | 1927-05-03 | William A Edwards | Method and means for homogenizing fluid-fuel mixtures |
US1650612A (en) | 1926-04-28 | 1927-11-29 | Uriah R Denniston | Hot-water heater |
US1650561A (en) | 1926-09-17 | 1927-11-22 | Tabor Mfg Co | Liquid-fuel burner |
US1711154A (en) * | 1926-12-30 | 1929-04-30 | Turbinator Company Inc | Mixing and grinding device |
US2115123A (en) * | 1937-07-20 | 1938-04-26 | Gas Fuel Corp | Apparatus for making emulsified compounds and colloidal compounds |
US2688470A (en) | 1946-09-13 | 1954-09-07 | Marco Company Inc | Premixer and juicer unit |
US2606502A (en) | 1948-04-15 | 1952-08-12 | George A Carlson | Rotary pump |
US2639901A (en) * | 1951-11-20 | 1953-05-26 | Nat Gypsum Co | Pin mixer |
US2798698A (en) | 1954-12-27 | 1957-07-09 | American Viscose Corp | Combined injection and blending apparatus |
SU127999A1 (en) | 1959-04-09 | 1959-11-30 | А.А. Барам | Rotary apparatus for the interaction of a liquid with a liquid, gas or powdery body |
US3182975A (en) * | 1961-05-04 | 1965-05-11 | Nodaway Valley Foods Inc | Steam injection heater |
US3194540A (en) | 1961-07-28 | 1965-07-13 | Liberty Nat Bank And Trust Com | Homogenizing apparatus |
GB1029797A (en) | 1963-09-13 | 1966-05-18 | British Belting & Asbestos Ltd | Heat generating unit for vulcanising belt joints |
DE1557171B2 (en) | 1966-10-28 | 1970-07-30 | Fr August Neidig Soehne Maschi | Device for homogenizing and mixing liquid, pasty and pasty media |
CH517515A (en) | 1970-01-30 | 1972-01-15 | Bayer Ag | Device for the production of emulsions or suspensions |
US3925243A (en) | 1970-06-01 | 1975-12-09 | Hans G Brogli | Apparatus for the manufacture of emulsions |
SU495862A1 (en) | 1972-03-01 | 1976-08-05 | Предприятие П/Я М-5755 | Apparatus for producing acoustic oscillations in a flow-through liquid medium |
US3980280A (en) | 1972-06-05 | 1976-09-14 | Energy Research & Generation, Inc. | Oscillatory mixer and method |
US4163712A (en) | 1973-01-08 | 1979-08-07 | Boc Limited | Treatment of liquid |
US3986709A (en) | 1973-07-19 | 1976-10-19 | Shell Oil Company | Direct gassing extruder with gas pockets |
SU495099A2 (en) | 1973-08-30 | 1975-12-15 | Cavitation generator | |
US4051204A (en) | 1973-12-21 | 1977-09-27 | Hans Muller | Apparatus for mixing a liquid phase and a gaseous phase |
DE2363888A1 (en) | 1973-12-21 | 1975-07-03 | Auer Hans Heinrich | DEVICE WITH ROTATING TOOLS FOR THE CONTINUOUS TREATMENT OF SUBSTANCES IN FLOWABLE FORM |
CH604861A5 (en) | 1974-05-10 | 1978-09-15 | Hiroyuki Iwako | |
US3957445A (en) * | 1974-06-12 | 1976-05-18 | General Motors Corporation | Engine exhaust system with monolithic catalyst element |
DD124023A1 (en) | 1974-10-09 | 1977-02-02 | ||
JPS5510545B2 (en) | 1974-12-17 | 1980-03-17 | ||
CS176645B1 (en) | 1975-01-24 | 1977-06-30 | ||
US4057223A (en) | 1975-10-03 | 1977-11-08 | Nalco Chemical Company | Mixing block for mixing polymers |
IT1075218B (en) | 1975-12-12 | 1985-04-22 | Dynatrol Consult | APPARATUS FOR MIXING FLUIDS |
US4089507A (en) * | 1976-03-15 | 1978-05-16 | Sumitomo Heavy Industries, Ltd. | Method and apparatus for maintaining uniformity of mixed dust slurry stored in a basin |
US4162153A (en) | 1976-04-12 | 1979-07-24 | Air Products And Chemicals, Inc. | High nitrogen and phosphorous content biomass produced by treatment of a BOD-containing material |
US4057933A (en) | 1976-05-05 | 1977-11-15 | Enyeart Lyle F | Apparatus for aerating comminuted matter such as soil |
US4116164A (en) | 1976-05-19 | 1978-09-26 | Air Products And Chemicals, Inc. | Method of fish farming |
US4049240A (en) | 1976-06-16 | 1977-09-20 | Ecolaire Incorporated | Continuous mixer and unloader |
US4175873A (en) | 1976-09-10 | 1979-11-27 | Funken Co., Ltd. | Process and apparatus for mechanically mixing two immiscible liquids and one or more other substances |
US4127332A (en) | 1976-11-19 | 1978-11-28 | Daedalean Associates, Inc. | Homogenizing method and apparatus |
US4117550A (en) | 1977-02-14 | 1978-09-26 | Folland Enertec Ltd. | Emulsifying system |
FI64569C (en) | 1977-04-04 | 1983-12-12 | Dyno Industrier As | FOERFARANDE FOER KONTINUERLIG FRAMSTAELLNING AV ETT SPRAENGAEMNE GENOM ATT SAMMANBLANDA MINST TVAO FLYTANDE COMPONENTS OC ANORDNING FOER UTFOERANDE AV FOERFARANDET |
DE2801549C2 (en) * | 1978-01-14 | 1982-10-21 | Franz Joseph 6450 Hanau Backhaus | Device for mixing ingredients for making sauces |
US4159944A (en) | 1978-02-13 | 1979-07-03 | Erickson Lennart G | Wastewater energy recycling method |
US4394966A (en) | 1978-05-09 | 1983-07-26 | Snyder Industries, Inc. | Spraying apparatus having a fluid storage tank with agitator and anti-vortex tank fittings |
DE2954535C2 (en) | 1978-09-26 | 1988-02-18 | Tashkent Avtomobil Dorozh Inst | |
US4263003A (en) * | 1979-05-08 | 1981-04-21 | Graco, Inc. | Method of mixing liquids in closed containers |
JPS5665627A (en) * | 1979-11-05 | 1981-06-03 | Agency Of Ind Science & Technol | Method of combining particles of liquid, etc. |
SU889078A1 (en) | 1979-12-05 | 1981-12-15 | За витель В. Н. Долгополов | Rotary powder distributing device |
US4261521A (en) * | 1980-03-13 | 1981-04-14 | Ashbrook Clifford L | Method and apparatus for reducing molecular agglomerate sizes in fluids |
SU921611A1 (en) | 1980-07-21 | 1982-04-23 | Ордена "Знак Почета" Домостроительный Комбинат N1 Комбината "Харьковжилстрой" | Rotor apparatus |
US4361414A (en) | 1980-07-23 | 1982-11-30 | Banyaszati Kutato Intezet | Equipment for the delivery of slurries and for refinement during delivery |
DE3108913A1 (en) | 1981-03-09 | 1982-09-23 | Ruhrkohle Ag, 4300 Essen | METHOD AND DEVICE FOR THE TREATMENT OF ASH-RICH CARBON SLUDGE BY FLOTATION, IN PARTICULAR FOR THE TREATMENT OF GAS AND GAS FLAME COALS WHICH ARE DIFFICULT TO FLOT |
US4408890A (en) | 1981-03-11 | 1983-10-11 | E. I. Du Pont De Nemours And Company | Pigment pre-blending mixhead attachment |
NL8101294A (en) * | 1981-03-17 | 1982-10-18 | Tno | STIRRER WITH CONTINUOUS INCURRED TRIANGULAR, RADIAL BLADES. |
US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
US4393017A (en) | 1981-06-18 | 1983-07-12 | The B. F. Goodrich Company | Apparatus and method for making foamed resin products |
US4684614A (en) | 1981-08-10 | 1987-08-04 | Ceskoslovenska Akademie Ved | Mixing or pumping apparatus for the treatment of flowable thin or highly viscous media |
SE427245B (en) * | 1982-01-29 | 1983-03-21 | Sjoenell Goeran | PROCEDURE FOR MIXING A SUBSTANCE, EX CYTOSTATICS, STORED IN A SUBSTANCES OR EQUIVALENT AMPULA, WITH ANOTHER SUBSTANCE, EX STERILATED WATER, LIKASA SUBSTANCED IN A SUBSTANCES OR OTHER SUBSTANCES |
US4441823A (en) * | 1982-07-19 | 1984-04-10 | Power Harold H | Static line mixer |
US4474479A (en) | 1982-08-30 | 1984-10-02 | Chemfix Technologies, Inc. | Apparatus for treating liquid and semi-solid organic waste materials |
US4469595A (en) | 1982-09-30 | 1984-09-04 | Protectaire Systems Company | Filter assembly for a spray booth |
JPS59203632A (en) | 1983-05-06 | 1984-11-17 | Fuji Photo Film Co Ltd | Emulsifying method |
US4619072A (en) | 1983-09-09 | 1986-10-28 | Privett Eric B | Method and apparatus for irrigating plants |
SE445712B (en) * | 1983-12-08 | 1986-07-14 | Boliden Ab | PROCEDURE FOR DISTRIBUTION OF A WATER PURIFICATION CHEMISTRY AND DEVICE FOR IMPLEMENTATION OF THE PROCEDURE |
FR2559855B1 (en) | 1984-02-21 | 1986-10-31 | Schlumberger Cie Dowell | PROCESS FOR IMPROVING THE CHARACTERISTICS OF A CEMENT MILK FOR WELL CEMENTING |
DE3406383C2 (en) * | 1984-02-22 | 1986-08-21 | Hoesch Ag, 4600 Dortmund | Device for the treatment of sludge from dedusting systems |
US4594228A (en) | 1984-05-21 | 1986-06-10 | The Standard Oil Company | Mixing apparatus |
SU1281290A1 (en) | 1984-05-29 | 1987-01-07 | Киевский технологический институт легкой промышленности | Rotor of centrifugal mixer of continuous action |
DE3436049A1 (en) | 1984-10-02 | 1986-04-03 | Koch Kurt | Process and apparatus for detoxifying oxidisable substances, in particular for the mineralisation of residues from the production of herbicides or insecticides, such as dioxin or the like |
IT1198946B (en) * | 1984-10-26 | 1988-12-21 | Fulmine Srl | DEVICE FOR HEATING AND EMULSION OF MILK IN SPECIES FOR THE PREPARATION OF THE SO-CALLED CAPPUCCINO |
ES8700918A1 (en) | 1985-01-31 | 1986-11-16 | Spidem Srl | An emulsifier unit particularly for emulsifying steam and milk to prepare cappuccino's and the like beverages. |
US4764283A (en) | 1985-04-24 | 1988-08-16 | Ashbrook Clifford L | Method and apparatus for treating cooling tower water |
US4957626A (en) | 1985-04-24 | 1990-09-18 | Quinetics Corporation | Method and apparatus for treating water in beverage and ice machines |
DE3680756D1 (en) * | 1985-11-28 | 1991-09-12 | Matsushita Electric Ind Co Ltd | APPARATUS FOR MIXING DIFFERENT LIQUIDS. |
NO158082C (en) | 1986-02-11 | 1988-07-20 | Norsk Hydro As | METHOD AND PLANT FOR WATER TREATMENT, SPECIAL OXYGEN ENRICHMENT OF WATER. |
US4696283A (en) | 1986-03-06 | 1987-09-29 | Kohlmetz Charles W | Kinetic heater |
US4664680A (en) * | 1986-04-07 | 1987-05-12 | Atec Inc. | Method and system for enriching oxygen content of water |
NL8602338A (en) | 1986-09-16 | 1988-04-18 | Hoogovens Groep Bv | GAS MIXER. |
US4749493A (en) | 1986-10-07 | 1988-06-07 | Hicks Charles E | Method and apparatus for oxygenating water |
US4753535A (en) | 1987-03-16 | 1988-06-28 | Komax Systems, Inc. | Motionless mixer |
DE3717969C1 (en) | 1987-05-27 | 1988-07-14 | Giselher Dr Gust | Method and device for generating defined ground shear stresses |
US4778336A (en) | 1987-07-09 | 1988-10-18 | Weil Pump Company | Cutter pump subassembly |
US4880445A (en) | 1988-01-20 | 1989-11-14 | Watten Barnaby J | Multiple stage gas absorber |
CH673643A5 (en) | 1988-02-18 | 1990-03-30 | Sulzer Ag | |
SU1584990A1 (en) | 1988-02-29 | 1990-08-15 | Московский Горный Институт | Rotary apparatus |
DE68923718T2 (en) | 1988-03-14 | 1996-01-18 | Kanegafuchi Chemical Ind | Continuous mixer for two liquids. |
US4999015A (en) * | 1988-05-27 | 1991-03-12 | Demaris Elbert E | High speed rotational dispersion device using short shear path |
US4972801A (en) | 1988-08-15 | 1990-11-27 | Hunt Robert D | Pumping system for producing oxygen enriched water useful in the growing of aquatic life |
JP2774519B2 (en) | 1988-09-06 | 1998-07-09 | バブコツク日立株式会社 | Wet exhaust gas desulfurization equipment |
US5052813A (en) | 1988-11-08 | 1991-10-01 | Brian Latto | Tube type vortex ring mixers |
DE3843543C2 (en) | 1988-12-23 | 2000-11-23 | Thyssen Gas | Process for the reduction of nitrogen oxides contained in flue gases from combustion plants |
US4973168A (en) | 1989-01-13 | 1990-11-27 | Chan Kwan Ho | Vacuum mixing/bone cement cartridge and kit |
SU1706683A1 (en) | 1989-02-08 | 1992-01-23 | Ю.Г. Петров | Emulsifier |
US5024647A (en) | 1989-06-13 | 1991-06-18 | The United States Of America As Represented By The United States Department Of Energy | Centrifugal contactor with liquid mixing and flow control vanes and method of mixing liquids of different phases |
US5005982A (en) * | 1989-06-21 | 1991-04-09 | Kistner Kenneth J | Material processor |
CA2026298A1 (en) * | 1989-09-27 | 1991-03-28 | Alex C. Kuo | Method and apparatus for metering and mixing non-compressible and compressible fluids |
FR2654584B1 (en) | 1989-11-20 | 1992-05-22 | Chauveau Jean Marie | REACTOR FOR TREATING A COCOA LIQUOR AND ITS DERIVATIVES. |
RU1768269C (en) | 1990-01-30 | 1992-10-15 | Тамбовский институт химического машиностроения | Rotor apparatus |
RU1773469C (en) | 1990-04-26 | 1992-11-07 | Тамбовский институт химического машиностроения | Rotary apparatus |
JP2630501B2 (en) | 1990-11-19 | 1997-07-16 | 富士写真フイルム株式会社 | Emulsification method and apparatus |
US5851068A (en) | 1990-12-04 | 1998-12-22 | The Maitland Co. | Intermodal transportation of sedimentary substances |
SE468341C (en) | 1991-03-20 | 1997-04-27 | Kvaerner Pulping Tech | Apparatus for mixing a suspension of a cellulosic fibrous material and a fluid |
RU1820861C (en) | 1991-06-27 | 1993-06-07 | Алексей Александрович Захваткин | Centrifugal disperser |
WO1993000156A1 (en) | 1991-06-29 | 1993-01-07 | Miyazaki-Ken | Monodisperse single and double emulsions and production thereof |
MX9100106A (en) | 1991-07-08 | 1993-01-01 | Oscar Mario Guagnelli Hidalgo | IMPROVEMENTS IN THE SYSTEM FOR CONTINUOUS MIXING IN SOLID, LIQUID AND / OR GASEOUS PARTICLES IN ALL ALTERNATIVES. |
EP0555498A1 (en) | 1992-02-11 | 1993-08-18 | April Dynamics Industries 1990 Ltd. | A two-phase supersonic flow system |
FR2688719B1 (en) | 1992-03-18 | 1996-09-20 | Assistance Maintenance Indle G | SCREW MIXER, PARTICULARLY FOR FOUNDRY MOLDS. |
US5300266A (en) * | 1992-05-27 | 1994-04-05 | Scientific Products Corporation | Electrical apparatus and method for generating antibiotic |
US5318702A (en) | 1992-06-18 | 1994-06-07 | Ashbrook Clifford L | Fluid treating apparatus |
US5561944A (en) | 1992-11-04 | 1996-10-08 | African Oxygen Limited | Method and apparatus for enhancing the growth and quality of edible plants |
BE1008407A6 (en) | 1993-02-12 | 1996-05-07 | Mach Collette S A Nv | MIXER FOR AERATING AND MIXING PUMPABLE, SEMI-LIQUID PRODUCTS. |
US5770062A (en) | 1993-05-03 | 1998-06-23 | Wildlife Science, Inc. | Device for aiding the solubilization of gases in liquids |
DE4317078A1 (en) * | 1993-05-21 | 1994-11-24 | Hans Bruno Klomann | Method of maintaining the optimum oxygen content of the eye required for the vision of the healthy human being, especially of contact lens wearers |
AU683485B2 (en) * | 1993-07-02 | 1997-11-13 | Molecular Biosystems, Inc. | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
US5551859A (en) | 1993-07-19 | 1996-09-03 | Novacor Chemicals (International) S.A. | Particulator |
US5341768A (en) | 1993-09-21 | 1994-08-30 | Kinetic Systems, Inc. | Apparatus for frictionally heating liquid |
US5813758A (en) | 1993-12-10 | 1998-09-29 | Ahlstrom Machinery Inc. | Concentric ring fluidizing mixer |
US5450368A (en) | 1993-12-28 | 1995-09-12 | Three Bond Co., Ltd. | Two liquid type mixer |
FI103019B (en) | 1994-01-25 | 1999-04-15 | Andritz Ahlstrom Oy | Process and apparatus for mixing a gaseous chemical in a fiber suspension |
US5435913A (en) | 1994-04-14 | 1995-07-25 | Ashbrook; Clifford L. | Fluid treating apparatus |
CA2146090C (en) | 1994-05-10 | 1998-11-24 | Mark E. Mitchell | Apparatus and method of mixing materials in a sterile environment |
RU2140898C1 (en) | 1994-05-11 | 1999-11-10 | Праксайр Текнолоджи, Инк. | Method of oxidation of organic compounds and system for its embodiment |
US6380264B1 (en) * | 1994-06-23 | 2002-04-30 | Kimberly-Clark Corporation | Apparatus and method for emulsifying a pressurized multi-component liquid |
WO1996002310A1 (en) | 1994-07-13 | 1996-02-01 | Mazzei Angelo L | Gas injection into liquid and removal of undissolved gas |
US5496108A (en) * | 1994-07-27 | 1996-03-05 | Sukup Manufacturing Company | Method and means for adding moisture to particulate material |
JP3560652B2 (en) | 1994-09-06 | 2004-09-02 | コニカミノルタホールディングス株式会社 | Mixing method |
CA2158522C (en) | 1994-09-19 | 2001-04-10 | Daniel R. Roll | Mixer for mixing multi-phase fluids |
US5419306A (en) * | 1994-10-05 | 1995-05-30 | Huffman; Michael T. | Apparatus for heating liquids |
US5671664A (en) | 1994-10-27 | 1997-09-30 | Jacobson; Glenn R. | Combination blender and food washing apparatus |
US6676900B1 (en) * | 1994-12-09 | 2004-01-13 | Therox, Inc. | Method for the preparation and delivery of gas-enriched fluids |
US6312647B1 (en) | 1994-12-09 | 2001-11-06 | Wayne State University | Method for enriching a fluid with oxygen |
US5569416A (en) | 1995-01-23 | 1996-10-29 | Cross; Billy G. | Apparatus for aerating fish ponds and lakes |
JP3439860B2 (en) | 1995-01-24 | 2003-08-25 | 東レ・ダウコーニング・シリコーン株式会社 | Continuous production method of organopolysiloxane emulsion |
US5538343A (en) | 1995-03-06 | 1996-07-23 | E. I. Du Pond De Nemours And Company | Apparatus and method for liquid mixing employing nip zones |
US5511877A (en) * | 1995-03-20 | 1996-04-30 | Komax Systems, Inc. | Staged rotary mixer |
US5814222A (en) * | 1995-03-31 | 1998-09-29 | Life International Products, Inc. | Oxygen enriched liquids, method and apparatus for making, and applications thereof |
US5616304A (en) * | 1995-04-21 | 1997-04-01 | Innovative Biosystems, Inc. | Slurry reactor |
US5779996A (en) | 1995-04-21 | 1998-07-14 | Innovative Biosystems, Inc. | Microbial remediation reactor and process |
US5613558A (en) | 1995-06-02 | 1997-03-25 | Bj Services Company | Method for controlling the set time of cement |
US5921679A (en) | 1995-09-25 | 1999-07-13 | Rutgers, The State University Of New Jersey | Method of chaotic mixing and improved stirred tank reactors |
US5845993A (en) | 1995-10-12 | 1998-12-08 | The Dow Chemical Company | Shear mixing apparatus and use thereof |
US6135628A (en) | 1995-10-13 | 2000-10-24 | Boehringer Ingelheim Pharmceuticals, Inc. | Method and apparatus for homogenizing aerosol formulations |
RU2091151C1 (en) | 1995-11-01 | 1997-09-27 | Российский заочный институт текстильной и легкой промышленности | Ultrasonic device for preparation of emulsions |
US5697187A (en) | 1995-12-13 | 1997-12-16 | Oxlon, Inc. | Method for treatment of crops by an irrigation solution |
EP0880473A4 (en) | 1996-01-24 | 1999-12-08 | Life Int Products Inc | Oxygenating apparatus, method for oxygenating water therewith, and applications thereof |
EP0879363B1 (en) | 1996-02-15 | 2002-09-11 | Oleg Vyacheslavovich Kozyuk | Method and device for obtaining a free disperse system in liquid |
FR2746258B1 (en) * | 1996-03-22 | 1998-04-30 | Air Liquide | METHOD FOR OPTIMIZING FISH GROWTH BY CONTROLLED OXYGEN INJECTION |
FR2747321B1 (en) | 1996-04-16 | 1998-07-10 | Centre Nat Rech Scient | PROCESS FOR THE PREPARATION OF AN EMULSION |
JPH09285230A (en) * | 1996-04-24 | 1997-11-04 | Fuaamaazu Design Kk | Hydroponic apparatus |
JPH1029213A (en) * | 1996-07-15 | 1998-02-03 | Toray Dow Corning Silicone Co Ltd | Liquid material continuous mixing apparatus |
US5834519A (en) * | 1996-10-11 | 1998-11-10 | Wayne State University | Stabilized gas-supersaturated emulsions and suspensions |
JPH10216408A (en) | 1996-12-02 | 1998-08-18 | Kobayashi Seisakusho:Kk | Dissolver for flocculant |
ID21814A (en) | 1997-01-07 | 1999-07-29 | Shell Int Research | FLUID RESERVOIRS AND PROCESSES THAT USE THE TOOL |
EP1030733A1 (en) | 1997-02-05 | 2000-08-30 | California Institute Of Technology | Microfluidic sub-millisecond mixers |
US5911870A (en) | 1997-04-11 | 1999-06-15 | H20 Technologies, Ltd. | Housing and method that provide extended resident time for dissolving generated oxygen into water |
SE509103C2 (en) | 1997-04-22 | 1998-12-07 | Tetra Laval Holdings & Finance | homogenizer |
US5791780A (en) | 1997-04-30 | 1998-08-11 | Chemineer, Inc. | Impeller assembly with asymmetric concave blades |
DE19718740A1 (en) | 1997-05-02 | 1998-11-05 | Hoechst Ag | Process for the granulation of aerogels |
US6326047B1 (en) | 1997-05-30 | 2001-12-04 | Stevens-Lee Company | Apparatus and method for making frozen drinks |
US5925292A (en) | 1997-06-02 | 1999-07-20 | Aqua Life Corporation | Water charging machine |
US5942161A (en) | 1997-07-16 | 1999-08-24 | Battelle Memorial Institute | Device and process for liquid treatment |
US6488765B1 (en) * | 1997-07-30 | 2002-12-03 | Cemex, Inc. | Oxygen enrichment of cement kiln system combustion |
US5782556A (en) | 1997-09-04 | 1998-07-21 | Chu; Chai-Kan | Apparatus for quickly making multiple-phase microemulsion fuel oil |
US6042792A (en) * | 1997-09-18 | 2000-03-28 | International Flavors & Fragrances Inc. | Apparatus for preparing a solid phase microparticulate composition |
US6386751B1 (en) * | 1997-10-24 | 2002-05-14 | Diffusion Dynamics, Inc. | Diffuser/emulsifier |
EP0916391B1 (en) | 1997-11-13 | 2003-06-11 | Haldor Topsoe A/S | Mixing device and flue gas channel provided therewith |
IL122396A0 (en) | 1997-12-02 | 1998-06-15 | Pekerman Oleg | Method of heating and/or homogenizing of liquid products in a steam-liquid injector |
US6000840A (en) | 1997-12-17 | 1999-12-14 | Charles Ross & Son Company | Rotors and stators for mixers and emulsifiers |
US5931771A (en) | 1997-12-24 | 1999-08-03 | Kozyuk; Oleg V. | Method and apparatus for producing ultra-thin emulsions and dispersions |
WO1999033553A1 (en) | 1997-12-30 | 1999-07-08 | Hirofumi Ohnari | Swirling fine-bubble generator |
US5904851A (en) * | 1998-01-19 | 1999-05-18 | Life International Products, Inc. | Oxygenating apparatus, method for oxygenating liquid therewith, and applications thereof |
US5971601A (en) | 1998-02-06 | 1999-10-26 | Kozyuk; Oleg Vyacheslavovich | Method and apparatus of producing liquid disperse systems |
US5951922A (en) | 1998-02-10 | 1999-09-14 | Mazzei; Angelo L. | Aeration system for substantial bodies of water |
US6398402B1 (en) | 1998-02-11 | 2002-06-04 | Chris Thomas | Disposable disruptor agitator tool having a bladed rotor disposed in a stator |
RU2131761C1 (en) | 1998-03-25 | 1999-06-20 | Пименов Юрий Александрович | Vibrocavitation type homogenizing mixer |
US6488401B1 (en) | 1998-04-02 | 2002-12-03 | Anthony E. Seaman | Agitators for wave-making or mixing as for tanks, and pumps and filters |
US6120008A (en) | 1998-04-28 | 2000-09-19 | Life International Products, Inc. | Oxygenating apparatus, method for oxygenating a liquid therewith, and applications thereof |
SE513519C2 (en) * | 1998-09-15 | 2000-09-25 | Tetra Laval Holdings & Finance | Method for homogenizing a pressurized liquid emulsion |
US6086243A (en) | 1998-10-01 | 2000-07-11 | Sandia Corporation | Electrokinetic micro-fluid mixer |
US6443610B1 (en) | 1998-12-23 | 2002-09-03 | B.E.E. International | Processing product components |
US6238706B1 (en) | 1999-05-06 | 2001-05-29 | Grofish L.L.C. | Method of stimulating growth in aquatic animals using growth hormones |
US6279611B2 (en) | 1999-05-10 | 2001-08-28 | Hideto Uematsu | Apparatus for generating microbubbles while mixing an additive fluid with a mainstream liquid |
US6494055B1 (en) | 1999-05-20 | 2002-12-17 | Specialty Equipment Companies, Inc. | Beater/dasher for semi-frozen, frozen food dispensing machines |
EP1060786B1 (en) | 1999-06-15 | 2004-04-14 | Pfaudler Werke GmbH | Charging assembly for mixing vessel |
US6210030B1 (en) * | 1999-06-15 | 2001-04-03 | Jean-Pierre Ibar | Method and apparatus to control viscosity of molten plastics prior to a molding operation |
US6250609B1 (en) | 1999-06-30 | 2001-06-26 | Praxair Technology, Inc. | Method of making supersaturated oxygenated liquid |
US6471392B1 (en) | 2001-03-07 | 2002-10-29 | Holl Technologies Company | Methods and apparatus for materials processing |
US6412714B1 (en) | 1999-08-16 | 2002-07-02 | Anthony Witsken | Apparatus for mixing, grinding, dispersing or emulsifying |
FR2797561B1 (en) | 1999-08-18 | 2001-11-09 | Air Liquide | PROCESS FOR IMPROVING THE CONDITIONS FOR BREEDING FISH OPERATING IN OZONE WATER |
RU2165787C1 (en) | 1999-09-06 | 2001-04-27 | Тамбовский государственный технический университет | Rotary apparatus |
US6294212B1 (en) | 1999-09-20 | 2001-09-25 | Wenger Manufacturing Inc. | Method and apparatus for the production of high viscosity paste products with added components |
IT1313901B1 (en) * | 1999-10-25 | 2002-09-26 | Ernesto Marelli | APPARATUS AND METHOD FOR THE FORMATION OF ATOMISED STABILIZED MICROEMULSIONS |
US6276825B2 (en) | 1999-11-08 | 2001-08-21 | Occidental Chemical Corporation | Transportation of soluble solids |
US20010022755A1 (en) | 1999-12-20 | 2001-09-20 | Holtzapple Mark T. | Mixer system and method |
RU2166987C1 (en) | 2000-01-10 | 2001-05-20 | ООО "Альфа-Компани" | Cavitation apparatus |
US6290857B1 (en) | 2000-01-20 | 2001-09-18 | Mg Industries | Method for oxygenation of waste water |
US6530895B1 (en) * | 2000-01-25 | 2003-03-11 | Life International Products, Inc. | Oxygenating apparatus, method for oxygenating a liquid therewith, and applications thereof |
DE10009326A1 (en) | 2000-02-28 | 2001-08-30 | Rs Kavitationstechnik | Mixing device used for mixing emulsion or suspension comprises housing and flow through chamber whose cross-section is larger in flow direction of material stream which flows through it |
US6284293B1 (en) | 2000-04-12 | 2001-09-04 | Jeffery J. Crandall | Method for generating oxygenated water |
US6332706B1 (en) | 2000-04-18 | 2001-12-25 | Wine Swirl, Llc | Method for aerating wine |
IL135843A0 (en) | 2000-04-28 | 2001-05-20 | Ende Michael | Method for production of enhanced traceable and immunising drinking water and other liquids and gases, and devices for use thereof |
US6627784B2 (en) | 2000-05-17 | 2003-09-30 | Hydro Dynamics, Inc. | Highly efficient method of mixing dissimilar fluids using mechanically induced cavitation |
US20020064961A1 (en) | 2000-06-26 | 2002-05-30 | Applied Materials, Inc. | Method and apparatus for dissolving a gas into a liquid for single wet wafer processing |
US6557492B1 (en) | 2002-07-19 | 2003-05-06 | Sea Chick, Inc. | System for transporting and storing live fish, components thereof and methods based thereon |
US20020164379A1 (en) * | 2000-06-29 | 2002-11-07 | Toru Nishihara | Oxygen-containing ophthalmic composition |
US6576130B2 (en) | 2000-07-17 | 2003-06-10 | North American Wetland Engineering, Inc. | Absorption field reclamation and maintenance system |
US6431742B2 (en) | 2000-07-31 | 2002-08-13 | Dow Corning Toray Silicone Co., Ltd. | Continuous mixing apparatus with upper and lower disk impellers each having scrapers |
US7008535B1 (en) * | 2000-08-04 | 2006-03-07 | Wayne State University | Apparatus for oxygenating wastewater |
US6499671B1 (en) | 2000-09-01 | 2002-12-31 | Del Industries, Inc. | Ozone systems and methods for agricultural applications |
US6322055B1 (en) | 2000-10-02 | 2001-11-27 | Eco-Oxygen Technologies, Llc | Gas dissolving apparatus and method |
EP1201296A1 (en) | 2000-10-23 | 2002-05-02 | Roland Hänggi | Device for introducing a gas into a liquid |
US6632014B2 (en) | 2000-12-04 | 2003-10-14 | Yeda Research And Development Co., Ltd. | Device and method for mixing substances |
WO2002060458A2 (en) * | 2001-02-01 | 2002-08-08 | Hydron Technologies, Inc. | Compositions and method of tissue superoxygenation |
DE10105118A1 (en) | 2001-02-05 | 2002-08-08 | Paul Esser | Method and device for introducing a gas into a body of water |
US20030042174A1 (en) * | 2001-06-18 | 2003-03-06 | Petronetiics Llc. | Method to treat emulsified hydrocarbon mixtures |
CN1272095C (en) | 2002-01-25 | 2006-08-30 | Seair公司 | Diffuser and aerating apparatus therewith |
US7396441B2 (en) | 2002-02-22 | 2008-07-08 | Aqua Innovations, Inc. | Flow-through oxygenator |
EP1476400A4 (en) * | 2002-02-22 | 2008-04-16 | Aqua Innovations Inc | Microbubbles of oxygen |
US6733172B2 (en) | 2002-03-11 | 2004-05-11 | The Regents Of The University Of California | Magnetohydrodynamic (MHD) driven droplet mixer |
US6682215B2 (en) * | 2002-04-10 | 2004-01-27 | Fibermark, Inc. | Process and apparatus for making sheet of fibers using a foamed medium |
RU2284853C2 (en) | 2002-04-17 | 2006-10-10 | Майкродиффьюжн, Инк. | Diffuser-emulsifier |
US20030232114A1 (en) | 2002-06-13 | 2003-12-18 | Nikola Dekleva | Method for liquid enrichment with oxygen and applications of enriched liquids |
JP2004074131A (en) | 2002-08-16 | 2004-03-11 | Takeshi Nakajima | Liquid containing micro-bubbles and its production method |
DE10245042B4 (en) | 2002-09-26 | 2007-09-27 | DRäGER AEROSPACE GMBH | Apparatus for enriching air oxygen |
JP4005479B2 (en) | 2002-11-11 | 2007-11-07 | Thk株式会社 | Homogenizer |
US6796702B2 (en) | 2002-11-26 | 2004-09-28 | The Boeing Company | Automated sol-gel mixer |
US6619399B1 (en) | 2003-03-12 | 2003-09-16 | Halliburton Energy Services, Inc. | Foamed compositions and methods of use in subterranean zones |
US6936179B2 (en) | 2003-04-15 | 2005-08-30 | Dewald Jack J. | Method and apparatus for adding oxygen to drinking water |
-
2004
- 2004-06-25 US US10/877,106 patent/US7654728B2/en not_active Expired - Fee Related
-
2010
- 2010-02-01 US US12/697,846 patent/US20110008462A1/en not_active Abandoned
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2734728A (en) * | 1956-02-14 | myers | ||
US2278051A (en) * | 1940-04-11 | 1942-03-31 | American Viscose Corp | Apparatus for cutting and mixing |
US2969960A (en) * | 1957-06-05 | 1961-01-31 | Mobay Chemical Corp | Mixing apparatus |
US2970817A (en) * | 1958-08-04 | 1961-02-07 | Mobay Chemical Corp | Mixing apparatus |
US3174185A (en) * | 1961-05-01 | 1965-03-23 | Metal Box Co Ltd | Extrusion of molten thermoplastic material |
US3630498A (en) * | 1968-07-31 | 1971-12-28 | Namco Corp | Apparatus for gasifying and degasifying a liquid |
US3938783A (en) * | 1970-10-30 | 1976-02-17 | The Upjohn Company | Method for continuous mixing of foam materials |
US3791349A (en) * | 1973-01-29 | 1974-02-12 | Sonaqua Inc | Steam generator |
US3937445A (en) * | 1974-02-11 | 1976-02-10 | Vito Agosta | Process and apparatus for obtaining the emulsification of nonmiscible liquids |
US4004553A (en) * | 1974-03-25 | 1977-01-25 | Alfa-Laval Ab | Heat treating apparatus for liquids |
US4069147A (en) * | 1974-09-19 | 1978-01-17 | Chemetron Corporation | Waste water treatment with oxygen |
US4011027A (en) * | 1974-09-23 | 1977-03-08 | Escher Wyss G.M.B.H. | Stain removal apparatus |
US3939073A (en) * | 1974-11-26 | 1976-02-17 | Jules Bats | Apparatus for deodorizing liquids |
US4136971A (en) * | 1975-04-22 | 1979-01-30 | Varlamov Vladimir M | Apparatus for creating acoustic oscillations in a running liquid medium |
US4071225A (en) * | 1976-03-04 | 1978-01-31 | Holl Research Corporation | Apparatus and processes for the treatment of materials by ultrasonic longitudinal pressure oscillations |
US4014526A (en) * | 1976-04-26 | 1977-03-29 | Cramer Jr Roy A | Liquid moving and mixing apparatus |
US4144167A (en) * | 1977-04-14 | 1979-03-13 | Burkett Albert L | Sewage treatment system |
US4143639A (en) * | 1977-08-22 | 1979-03-13 | Frenette Eugene J | Friction heat space heater |
US4183681A (en) * | 1978-05-19 | 1980-01-15 | Exxon Research & Engineering Co. | Emulsion preparation method using a packed tube emulsifier |
US4316673A (en) * | 1978-08-08 | 1982-02-23 | General Dynamics, Pomona Division | Mixing device for simultaneously dispensing two-part liquid compounds from packaging kit |
US4436430A (en) * | 1979-05-17 | 1984-03-13 | Mayer Karl M | Device for the continuous mixing of a dry finished mortar |
US4318429A (en) * | 1979-05-23 | 1982-03-09 | Compagnie Generale Des Etablissements Michelin | Installation for preparing a liquid or pasty mixture intended to be molded and method for the use of said installation |
US4368986A (en) * | 1980-10-06 | 1983-01-18 | Harsco Corporation | Dual shell blender with intensifier |
US4424797A (en) * | 1981-10-13 | 1984-01-10 | Eugene Perkins | Heating device |
US4507285A (en) * | 1982-04-10 | 1985-03-26 | Kuehne Friedrich Wilhelm | Stabilized activated oxygen and pharmaceutical compositions containing said stabilized activated oxygen |
US4808007A (en) * | 1982-05-13 | 1989-02-28 | Komax Systems, Inc. | Dual viscosity mixer |
US4634675A (en) * | 1983-12-29 | 1987-01-06 | New Brunswick Scientific Co., Inc. | Agitator for a fermentation and tissue culturing vessel |
US4633909A (en) * | 1984-04-06 | 1987-01-06 | Degremont | Apparatus for the rapid in-line mixing of two fluids |
US4645606A (en) * | 1985-04-24 | 1987-02-24 | Ashbrook Clifford L | Magnetic molecular agglomerate reducer and method |
US4908101A (en) * | 1986-11-18 | 1990-03-13 | Hedemora Ab | Method and apparatus for mixing chemicals into fiber pulp |
US4906574A (en) * | 1987-06-12 | 1990-03-06 | Biogal Gyogyszergyar | Fermenting device for the culture of aerobic micro-organisms |
US4733972A (en) * | 1987-07-09 | 1988-03-29 | Aqua-Aerobic Systems, Inc. | Floating mixer apparatus with foam dispersing spray |
US4798176A (en) * | 1987-08-04 | 1989-01-17 | Perkins Eugene W | Apparatus for frictionally heating liquid |
US5176447A (en) * | 1988-04-29 | 1993-01-05 | Energiagazdalkodasi Intenzet | Turbomixer with rotating injector for mixing liquid |
US5711950A (en) * | 1990-01-12 | 1998-01-27 | Lorenzen; Lee H. | Process for preparing microclustered water |
US5185081A (en) * | 1990-04-04 | 1993-02-09 | Outokumpu Oy | Method and apparatus for mixing and separating two liquid phases while preventing aeration and emulsions using a mixer-settler |
US5082558A (en) * | 1990-08-31 | 1992-01-21 | Burris William A | Compact contact lens purification system using ozone generator |
US5275486A (en) * | 1990-09-06 | 1994-01-04 | Transsonic Uberschall-Anlagen Gmbh | Device for acting upon fluids by means of a shock wave |
US6344489B1 (en) * | 1991-02-14 | 2002-02-05 | Wayne State University | Stabilized gas-enriched and gas-supersaturated liquids |
US5188090A (en) * | 1991-04-08 | 1993-02-23 | Hydro Dynamics, Inc. | Apparatus for heating fluids |
US5868495A (en) * | 1991-07-08 | 1999-02-09 | Hidalgo; Oscar Mario Guagnelli | Method for treating fluent materials |
US5380471A (en) * | 1991-07-31 | 1995-01-10 | Mitsubishi Denki Kabushiki Kaisha | Aeration apparatus for producing ultrapure water |
US5281341A (en) * | 1991-08-09 | 1994-01-25 | Administrators Of The Tulane Educational Fund | Sludge treatment process |
US5378321A (en) * | 1992-03-04 | 1995-01-03 | Kamyr, Inc. | Varying annular fluidization zone for increased mixing efficiency in a medium consistency mixer |
US5279262A (en) * | 1992-06-04 | 1994-01-18 | Muehleck Norman J | Mechanical liquid vaporizing waterbrake |
US5380089A (en) * | 1992-07-29 | 1995-01-10 | Karasawa; Yukihiko | Emulsifying apparatus for solid-liquid multiphase flow and nozzle for solid-liquid multiphase flow |
US5279463A (en) * | 1992-08-26 | 1994-01-18 | Holl Richard A | Methods and apparatus for treating materials in liquids |
US5590961A (en) * | 1992-12-16 | 1997-01-07 | Niro Holding A/S | Method for injecting a first fluid into a second fluid and an apparatus for carrying out the method |
US5482369A (en) * | 1993-02-08 | 1996-01-09 | Verstallen; Adrian | Process for homogenizing essentially immiscible liquids for forming an emulsion |
US5720551A (en) * | 1994-10-28 | 1998-02-24 | Shechter; Tal | Forming emulsions |
US6019499A (en) * | 1995-04-18 | 2000-02-01 | Advanced Molecular Technologies, Llc | Method of conditioning hydrocarbon liquids and an apparatus for carrying out the method |
US6180059B1 (en) * | 1995-06-05 | 2001-01-30 | Therox, Inc. | Method for the preparation and delivery of gas-enriched fluids |
US5711887A (en) * | 1995-07-31 | 1998-01-27 | Global Water Industries, Inc. | Water purification system |
US5865537A (en) * | 1995-10-05 | 1999-02-02 | Sulzer Chemtech Ag | Mixing device for mixing a low-viscosity fluid into a high-viscosity fluid |
US5863120A (en) * | 1997-01-31 | 1999-01-26 | Beloit Technologies, Inc. | Medium consistency liquid mixture |
US5868944A (en) * | 1997-06-19 | 1999-02-09 | Oxygen8, Inc. | Oxygenated water cooler |
US6190549B1 (en) * | 1997-06-19 | 2001-02-20 | Oxygen8, Inc. | Oxygenated water cooler |
US6017447A (en) * | 1997-06-19 | 2000-01-25 | Oxygen8, Inc. | Oxygenated water cooler |
US7887698B2 (en) * | 1997-10-24 | 2011-02-15 | Revalesio Corporation | Diffuser/emulsifier for aquaculture applications |
US7179375B2 (en) * | 1997-10-24 | 2007-02-20 | Microdiffusion, Inc. | Diffuser/emulsifier for aquaculture applications |
US7654728B2 (en) * | 1997-10-24 | 2010-02-02 | Revalesio Corporation | System and method for therapeutic application of dissolved oxygen |
US20120015083A1 (en) * | 1997-10-24 | 2012-01-19 | Revalesio Corporation | Diffuser/emulsifier for aquaculture applications |
US6173526B1 (en) * | 1998-02-10 | 2001-01-16 | Angelo L. Mazzei | Beneficiation of soil with dissolved oxygen for growing crops |
US20030022288A1 (en) * | 1998-07-28 | 2003-01-30 | The Regents Of The University Of California | Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction |
US6682732B1 (en) * | 1998-08-28 | 2004-01-27 | The University Of Bath | Treatment of lesions |
US6338569B1 (en) * | 1998-10-27 | 2002-01-15 | Mcgill Shane R. | Food blending apparatus |
US6193786B1 (en) * | 1998-12-11 | 2001-02-27 | Pacific Gas And Electric Company | Portable oil degasification apparatus |
US6524475B1 (en) * | 1999-05-25 | 2003-02-25 | Miox Corporation | Portable water disinfection system |
US20070003497A1 (en) * | 1999-10-26 | 2007-01-04 | Holloway William D Jr | Device and method for mixing liquids and oils or particulate solids and mixtures generated therefrom |
US6521248B1 (en) * | 1999-10-26 | 2003-02-18 | Bio-Hydration Research Lab, Inc. | Micro-cluster liquids and methods of making and using them |
US20040027915A1 (en) * | 2000-08-25 | 2004-02-12 | Holger Lowe | Method and statistical micromixer for mixing at least two liquids |
US20040004042A1 (en) * | 2000-09-27 | 2004-01-08 | Hadley Darrell J | Apparatus and method for increasing oxygen levels in a liquid |
US20040019319A1 (en) * | 2001-03-20 | 2004-01-29 | Derek Daw J. | Method for enriching a bodily fluid with a gas |
US6837986B2 (en) * | 2001-05-18 | 2005-01-04 | Mikuni Corporation | Device for producing electrolytic water and process for producing electrolytic water |
US20060030900A1 (en) * | 2001-07-18 | 2006-02-09 | Eckert C E | Two-phase oxygenated solution and method of use |
US20030017001A1 (en) * | 2001-07-23 | 2003-01-23 | Ogi Jeffrey M. | Deep root watering unit |
US6857774B2 (en) * | 2002-08-02 | 2005-02-22 | Five Star Technologies, Inc. | Devices for cavitational mixing and pumping and methods of using same |
US20040022122A1 (en) * | 2002-08-02 | 2004-02-05 | Kozyuk Oleg V. | Devices for cavitational mixing and pumping and methods of using same |
US20070021331A1 (en) * | 2003-06-18 | 2007-01-25 | Tranzyme Pharma Inc. | Methods of using macrocyclic modulators of the ghrelin receptor |
US7316501B2 (en) * | 2004-05-20 | 2008-01-08 | Christian Thoma | Apparatus and method for mixing dissimilar fluids |
US20060039902A1 (en) * | 2004-08-05 | 2006-02-23 | Young Deborah A | Antagonizing interleukin-21 receptor activity |
US20060039910A1 (en) * | 2004-08-20 | 2006-02-23 | Amgen Inc. | Methods and compositions for treating allergic inflammation |
US7334781B2 (en) * | 2004-09-13 | 2008-02-26 | Joseph Louis Donnelly | System and method for treating fuel to increase fuel efficiency in internal combustion engines |
US20080050452A1 (en) * | 2006-06-30 | 2008-02-28 | Nucryst Pharmaceuticals | Metal-containing formulations and methods of use |
US20120034696A1 (en) * | 2006-10-25 | 2012-02-09 | Revalesio Corporation | Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures |
US20100038244A1 (en) * | 2006-10-25 | 2010-02-18 | Revalesio Corporation | Mixing device |
US20100021464A1 (en) * | 2006-10-25 | 2010-01-28 | Revalesio Corporation | Methods of wound care and treatment |
US20100028442A1 (en) * | 2006-10-25 | 2010-02-04 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
US20100008997A1 (en) * | 2007-10-25 | 2010-01-14 | Revalesio Corporation | Compositions and methods for treating asthma and other lung disorders |
US20100029764A1 (en) * | 2007-10-25 | 2010-02-04 | Revalesio Corporation | Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction |
US20100028443A1 (en) * | 2007-10-25 | 2010-02-04 | Revalesio Corporation | Compositions and methods for treating inflammation |
US20100009008A1 (en) * | 2007-10-25 | 2010-01-14 | Revalesio Corporation | Bacteriostatic or bacteriocidal compositions and methods |
US20100004189A1 (en) * | 2007-10-25 | 2010-01-07 | Revalesio Corporation | Compositions and methods for treating cystic fibrosis |
US20100028441A1 (en) * | 2008-04-28 | 2010-02-04 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
US20100015235A1 (en) * | 2008-04-28 | 2010-01-21 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
US20100003333A1 (en) * | 2008-05-01 | 2010-01-07 | Revalesio Corporation | Compositions and methods for treating digestive disorders |
US20120039951A1 (en) * | 2010-05-07 | 2012-02-16 | Revalesio Corporation | Compositions and methods for enhancing physiological performance and recovery time |
US20120039958A1 (en) * | 2010-08-12 | 2012-02-16 | Revalesio Corporation | Compositions and methods for treatment of taupathy |
US20120039884A1 (en) * | 2010-08-13 | 2012-02-16 | Revalesio Corporation | Compositions and methods for treating cardiovascular disease |
Non-Patent Citations (1)
Title |
---|
Pillsbury, A.F. 1981. The salinity of rivers. Scientific American. 245(1):54-65. * |
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AS | Assignment |
Owner name: REVALESIO CORPORATION, WASHINGTON Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KLENA, RICHARD A.;REEL/FRAME:025198/0319 Effective date: 20101022 Owner name: REVALESIO CORPORATION, WASHINGTON Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WOOD, ANTHONY B.;ARCHAMBEAU, GREGORY J.;SIGNING DATES FROM 20100921 TO 20100922;REEL/FRAME:025198/0291 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |