US20120008898A1 - Rotary Optical Probe - Google Patents
Rotary Optical Probe Download PDFInfo
- Publication number
- US20120008898A1 US20120008898A1 US13/125,176 US200913125176A US2012008898A1 US 20120008898 A1 US20120008898 A1 US 20120008898A1 US 200913125176 A US200913125176 A US 200913125176A US 2012008898 A1 US2012008898 A1 US 2012008898A1
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- Prior art keywords
- optical
- light
- optical path
- rotational
- optical waveguide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
- G01N21/474—Details of optical heads therefor, e.g. using optical fibres
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
Abstract
There is disclosed a probe (50) for directing light to an object to be measured and receiving light returned from the object to be measured, the probe including: an optical path (21) for transmitting light from a light source (10); a mirror member (52) for reflecting the light transmitted through the optical path (21); and a rotational oscillation mechanism (56) for rotatably oscillating the mirror member (52) and a tip end portion of the optical path (21) about a longitudinal axis of the optical path (21); wherein the rotational oscillation mechanism (56) is adapted to perform the rotational oscillation within a range defined by a torsional elasticity limit of the optical path (21). This configuration can provide an optical rotary probe with a simple structure and with high reliability, which is capable of suppressing optical losses and reflection ghosts.
Description
- The present invention relates to optical rotary probes, which are suitable for use in, for example, optical coherent tomography (OCT) apparatuses, for directing light toward an object to be measured and receiving light returned from the object to be measured.
- In recent years, for diagnosing body tissues, optical coherent tomography (OCT) apparatuses which are capable of obtaining optical information about insides of tissues are proposed, as well as imaging apparatuses for obtaining optical information about conditions of the surfaces of such tissues. Optical coherent tomography apparatuses employ techniques for dividing low-coherence light into two parts, further directing one part of the light toward an object to be measured and causing the returned scattering light modified with phase information about the object to interfere with the other part of light, further obtaining the phase information about the object from information about the intensity of the interfering light and, further, imaging the measured portion of the object (See Patent Document 1).
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- [PATENT DOCUMENT 1] JP 6-511312 A
- [PATENT DOCUMENT 2] JP 2007-222381 A (FIG. 14)
- [PATENT DOCUMENT 3] JP 2006-95143 A (FIG. 2)
- [PATENT DOCUMENT 4] JP 4-135550 A (FIG. 6)
- [PATENT DOCUMENT 5] U.S. Pat. No. 5,872,879 B
- [PATENT DOCUMENT 6] U.S. Pat. No. 5,949,929 B
- When diagnosing fine body tissues such as blood vessels, using optical signals, in general, a bendable thin optical probe which is formed of a fiber or the like can be used for rotational scanning about the axis of the probe to obtain images of inner walls and cross-sections of the blood vessels. In cases of such a rotational-scanning type optical probe, a mechanical break point is conventionally provided in the fiber optical path of the probe, and one side thereof is fixed while the other side is rotated for enabling scanning over the entire periphery with an angle of 360 degrees.
- However, a complicated mechanism is needed for suppressing optical losses and reflections around the break point. Further, in cases of obtaining tomography images such as OCTs, it is necessary to accurately suppress variation of the optical path length during rotating around the break point, which leads to an increase cost of the components and degraded reliability of the apparatus.
- Patent Documents 2 and 3 disclose rotational scanning in which a fiber probe is mechanically separated from a tip end mirror which can rotate. However, a mirror rotating mechanism must be located at the tip end of the probe, and the positions of the mirror and the fiber end face must be maintained with excellent accuracy, thereby resulting in the enlarged tip end of the probe.
- Patent Document 4 discloses that light condensed by a lens is introduced into a rotary fiber probe. However, in order to efficiently introduce light into the rotary probe, it is necessary to accurately adjust both of the rotating position of the probe and the condensing position of the lens. Furthermore, a larger amount of reflection at the incident end face of the probe may cause increased noises.
- Patent Documents 5 and 6. disclose that fiber coupling portions are formed as ferrules. However, it is necessary to accurately adjust the axial distance thereof. Furthermore, there is a possibility of fractures due to contact between the end faces, thereby degrading the reliability.
- It is an object of the present invention to provide an optical rotary probe with a simple structure and with high reliability, which is capable of suppressing optical losses and reflection ghosts.
- In order to attain the aforementioned object, according to the present invention, there is provided an optical rotary probe for directing light to an object to be measured and receiving light returned from the object to be measured, the optical rotary probe including: an optical waveguide for transmitting light from a light source; a mirror member for reflecting the light transmitted through the optical waveguide; and a rotational oscillation mechanism for rotatably oscillating the mirror member and a tip end portion of the optical waveguide about a longitudinal axis of the optical waveguide; wherein the rotational oscillation mechanism is adapted to perform the rotational oscillation within a range defined by a torsional elasticity limit of the optical waveguide.
- In the present invention, a fixing holding member for restricting the torsional range is preferably provided halfway through the optical waveguide.
- In the present invention, a sag is preferably provided in the torsionally oscillating portion of the optical waveguide.
- In the present invention, it is preferable that measurement is performed within a constant speed interval of the torsional oscillation while no measurement is performed within a non-constant speed interval.
- In the present invention, a second optical waveguide is preferably further provided for transmitting return light from the object to be measured.
- In the present invention, the respective optical waveguides are preferably housed in a single bendable flexible member.
- In the present invention, the rotational oscillation mechanism is preferably adapted to integrally rotatably oscillate the respective optical waveguides with respect to the bendable flexible member.
- According to the present invention, the mirror member and the tip end portion of the optical waveguide are rotated and oscillated within a range defined by a torsional elasticity limit of the optical waveguide, which lead to eliminate the necessity of providing a mechanical break point halfway through the optical waveguide. This can suppress optical losses and reflection ghosts induced by such a mechanical break point, thereby achieving rotational scanning with higher reliability and lower cost.
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FIG. 1 is a structural view illustrating an example of an optical tomography measurement apparatus to which the present invention is applicable. -
FIG. 2 is a structural view illustrating a probe according to a first embodiment. -
FIG. 3 is a structural view illustrating a probe according to a second embodiment. -
FIG. 4 is a structural view illustrating a probe according to a third embodiment. -
FIG. 5 is a structural view illustrating a probe according to a fourth embodiment. - 10 Light source
- 11, 21, 31, 41 a and 41 b Optical path
- 12, 40 Coupler
- 21 a Torsion portion
- 21 b Sag portion
- 22, 32 Circulator
- 25 Fixing holding member
- 30 Reference mirror
- 33 Attenuator
- 42 a, 42 b Differential detector
- 50 Probe
- 51 Objective lens
- 52 Mirror member
- 55 Rotational holding member
- 56 Rotational oscillation mechanism
- 57 Sheath
- 58 Sheath holding member
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FIG. 1 is a structural view illustrating an example of an optical tomography measurement apparatus to which the present invention is applicable. The optical tomography measurement apparatus, which is constituted as a Michelson interferometer with a low-coherence light source, includes alight source 10, acoupler 12,circulators attenuator 33, aprobe 50, areference mirror 30, acoupler 40,differential detectors optical paths optical paths - The
light source 10, which is constituted by an SLD or the like, is adapted to generate low-coherence light with, for example, a center wavelength of 1.3 micrometers (μm) and an oscillation spectrum width of about 50 nm. The light from thelight source 10 passes through theoptical path 11 and reaches thecoupler 12. - The
coupler 12, which is constituted by an optical fiber coupler, a beam splitter or the like, has a function of an optical splitting means for splitting the light from theoptical path 11 toward theoptical paths - Sample light split by the
coupler 12 passes through theoptical path 21 and thecirculator 22 and reaches theprobe 50. Theprobe 50 directs the sample light to an object to be measured. The sample return light, which has been reflected according to the internal structure of the object to be measured, enters theprobe 50 again, and then passes backward through theoptical path 21 and thecirculator 22 and then reaches thecoupler 40. - Reference light split by the
coupler 12 passes through theoptical path 31, thecirculator 32 and theattenuator 33 and reaches thereference mirror 30. The reference return light, which is reflected by thereference mirror 30, passes backward through theoptical path 31, theattenuator 33 and thecirculator 32 and then reaches thecoupler 40. - The sample return light and the reference return light having passed backward through the
optical paths coupler 40 to generate interference light. Thecoupler 40, which is constituted by an optical fiber coupler, a beam splitter or the like, has a function of an optical interference means for causing the light passing backward through theoptical paths optical paths differential detectors differential detectors - The signals from the
differential detectors - Optical tomography measurements are generally classified into time domain OCTs (TD-OCTs) and Fourier domain OCTs (FD-OCTs). Further, Fourier domain OCTs are classified into swept-source type OCTs (SS-OCTs) and spectral-domain OCTs (SD-OCTs). Time domain OCTs modulate the phase of light according to scan signals using an optical phase modulation device provided in one or both of the
optical paths light source 10. Spectral-domain OCTs perform spectrometry using a diffraction grating on interference light generated by sample return light and reference return light to measure the spectrum resulted from the spectrometry using a liner image sensor. - The present invention is applicable to any of the aforementioned methods, but can be preferably applied to swept-source type OCTs or spectral-domain OCTs, since it is possible to eliminate the necessity of a mechanism for changing the optical path length with time being located in the reference optical path.
- In this embodiment, interference signals generated by sample return light and reference return light are differentially detected. Thus, signals generated by interfering the light from the sample optical path with the light from the reference optical path at the
coupler 40 can be increased in intensity due to differential detection of signals having opposite phases. On the other hand, for example, interference signals resulting from ghosts caused by optical surfaces of prisms which are placed in the sample optical path are simply split into the same phase by thecoupler 40, which can reduce noise signals through the differential detection, thereby resulting in better optical tomography images. - Further, sample light and reference light are transmitted through the respective different optical fibers, which enables the
attenuator 33 to be inserted only in the referenceoptical path 31. Thus, the amount of reference return light can be easily controlled, thereby achieving optimum adjustment of the amount of light for interference. Further, since sample light and reference light pass through the respective different optical paths, it is possible to eliminate ghost light induced in the sample optical path. -
FIG. 2 is a structural view illustrating the probe according to the first embodiment. Theprobe 50 includes theoptical path 21 formed of an optical fiber, anobjective lens 51, amirror member 52, a rotational holdingmember 55, arotational oscillation mechanism 56. - The
objective lens 51, which is constituted of, for example, a gradient index (GRIN) lens or a curved-surface lens, is fixed so that the tip end of theoptical path 21 is abutted on the incidence surface of theobjective lens 51. Themirror member 52, which is constituted of, for example, a reflection prism, is fixed so that the exit surface of theobjective lens 51 is abutted on the incidence surface of themirror member 52. - The sample light from the
light source 10 passes through theoptical path 21, and is condensed by theobjective lens 51, and then is reflected by themirror member 52 to spotlight the object to be measured. The sample return light reflected according to the internal structure of the object enters themirror member 52 again, and then passes backward through theobjective lens 51 and theoptical path 21, and then passes through thecirculator 22 as illustrated inFIG. 1 and returns to thecoupler 40. - The rotational holding
member 55 is formed of a hollow cylindrical member that can be made of a hard material, such as metal or plastic, or a bendable and flexible material. Theobjective lens 51 and themirror member 52 are secured to the inside of the tip end of the rotational holdingmember 55. The portion thereof facing to the exit surface of theobjective lens 51 is provided with an opening or a window made of a transparent material, through which light can pass. The rotational holdingmember 55 is supported rotatably about the longitudinal axis of the cylinder. - The
rotational oscillation mechanism 56, which is constituted of a motor or the like, is adapted to rotatably oscillate theobjective lens 51 and themirror member 52 about the longitudinal axis of theoptical path 21 through the rotational holdingmember 55, so that the object surrounding the rotational holdingmember 55 can be cylindrically scanned. In this case, the rotational oscillation can be performed within a range defined by a torsional elasticity limit of theoptical path 21, which lead to eliminate the necessity of providing a mechanical break point halfway through the optical waveguide, as in conventional structures. Therefore, it is possible to suppress optical losses and reflection ghosts caused by such a mechanical break point, thereby achieving rotational scanning with higher reliability and lower cost. - Further, since the
optical path 21 is constituted of an optical fiber, it is possible to reduce optical transmission losses in theoptical path 21. Furthermore, since theoptical path 21 can be freely bent, it is suitable for applications to endoscopes and vascular catheters. - In processing the interference signals generated by the sample return light and the reference return light, it is preferable that measurement is performed within a constant speed interval of the torsional oscillation while no measurement is performed within a non-constant speed interval. This can reduce the amount of image processing calculations required for building up optical topography images, thereby obtaining the images more quickly and reducing the data storage area required for image processing.
- In this regard, it is preferable to provide a detector for detecting the rotational angles of the rotating members including the rotational holding
member 55 and therotational oscillation mechanism 56, thereby determining the constant speed interval of the torsional oscillation. - Further, even when the rotational speed is varied, it is possible to output images while correcting any deviation of measuring positions based on rotational position information, thereby reducing image distortion due to the variation of the rotational speed.
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FIG. 3 is a structural view illustrating a probe according to the second embodiment. Theprobe 50 includes anoptical path 21 formed of an optical fiber, anobjective lens 51, amirror member 52, a rotational holdingmember 55, arotational oscillation mechanism 56, asheath 57, asheath holding member 58. The structure and operation for rotational scanning of sample light are the same as those according to the first embodiment inFIG. 2 and, therefore, will not be described redundantly. - The
sheath 57, which is formed of a hollow cylindrical member that can be made of a hard material, such as metal or plastic, or a bendable and flexible material, supports the rotational holdingmember 55 inside thereof so that it can be rotated. Thesheath holding member 58 fixes thesheath 57 for restricting the rotational movement of thesheath 57. - In this embodiment, a
fixing holding member 25 is installed halfway through theoptical path 21 for restricting the torsional range thereof. Installation of thefixing holding member 25 can restrict the area of thetorsion portion 21 a which is torsionally oscillated, out of the entireoptical path 21. This reduces variation of the elasticity limit due to bending or attitude change of theoptical path 21, thereby making it easy to set a maximum value of the amount of torsional rotation. -
FIG. 4 is a structural view illustrating a probe according to the third embodiment. Theprobe 50 includes anoptical path 21 formed of an optical fiber, anobjective lens 51, amirror member 52, a rotational holdingmember 55, arotational oscillation mechanism 56, asheath 57, asheath holding member 58. The structure and operation for rotational scanning of sample light are the same as those according to the first embodiment inFIG. 2 and, therefore, will not be described redundantly. Further, the structure of thesheath 57 is the same as that of the second embodiment inFIG. 3 and, therefore, will not be described redundantly. - In this embodiment, similarly to the second embodiment, a
fixing holding member 25 is installed halfway through theoptical path 21 for restricting the torsional range thereof. Installation of thefixing holding member 25 can restrict the area of thetorsion portion 21 a which is torsionally oscillated, out of the entireoptical path 21. This reduces variation of the elasticity limit due to bending or attitude change of theoptical path 21, thereby making it easy to set a maximum value of the amount of torsional rotation. - Further, it is preferable to provide a
sag portion 21 b halfway through theoptical path 21. By doing this, it is possible to increase the amount of rotation within an elasticity limit against torsional oscillation, thereby increasing the rotational speed and performing plural rotations. Further, thesag portion 21 b is preferably made to have a coil shape as illustrated inFIG. 4 . Thus, the permissible amount of torsional rotation can be increased with a smaller space, thereby downsizing theprobe 50. - The present invention is also applicable to probes for fluorometric determinations, spectroscopic determinations and confocal scanning, as well as to OCT probes. In cases of these probes, a total of two optical fibers are required, one being a source light guiding optical fiber for guiding light from a light source for illuminating an object to be measured, another being a measuring light guiding optical fiber for guiding fluorescence or scattering light from the illuminated object toward an optical detector or a spectroscope, therefore, it is difficult in general to perform rotational scanning over measuring areas.
- In this embodiment, the two optical fibers can be torsionally oscillated within the elasticity limit thereof, thereby obtaining rotational scanning images, without taking any specific measure for connection portion between the rotating portion and the fixed portion.
-
FIG. 5 is a structural view illustrating a probe according to the fourth embodiment. Theprobe 50 includes twooptical paths objective lens 51, amirror member 52, a rotational holdingmember 55, arotational oscillation mechanism 56, asheath 57, asheath holding member 58. The structure and operation for rotational scanning of sample light are the same as those according to the first embodiment inFIG. 2 and, therefore, will not be described redundantly. - The sample light from the
light source 10 passes through theoptical path 21 and is condensed by theobjective lens 51, and then is reflected by themirror member 52 to spotlight the object to be measured. Reflected light or fluorescent light generated by spot irradiation will become sample return light, which enters themirror member 52 again, and then passes through theobjective lens 51 and the secondoptical path 61, and then is received by anoptical detector 60. The detected signal is supplied to a signal processing device such as a computer, which performs measurement for changes of light intensity, spectroscopic spectra and the like. - As described above, sample light and sample return light are transmitted through the respective different
optical fibers - The rotational holding
member 55 integrally houses the twooptical paths objective lens 51 and themirror member 52 are secured to the inside of the tip end of the rotational holdingmember 55. - The
rotational oscillation mechanism 56, which is constituted of a motor or the like, is adapted to rotatably oscillate theobjective lens 51 and themirror member 52 about the longitudinal axis of theoptical paths member 55, so that the object surrounding the rotational holdingmember 55 can be cylindrically scanned. In this case, the rotational oscillation can be performed within a range defined by torsional elasticity limits of theoptical paths optical paths - The
sheath 57, which is formed of a single hollow cylindrical member that can be made of a hard material, such as metal or plastic, or a bendable and flexible material. Thesheath 57, supports the rotational holdingmember 55 inside thereof so that it can be rotated. Thesheath holding member 58 fixes thesheath 57 for restricting the rotational movement of thesheath 57. - In this embodiment, the two
optical paths single sheath 57, which facilitates handling of theprobe 50. Further, therotational oscillation mechanism 56 is adapted to integrally rotate and oscillate the respectiveoptical paths sheath 57, thereby suppressing influences on the object during rotational scanning. Further, the object is free of any load, thereby realizing smooth rotational scanning. - In this embodiment, similarly to the second and third embodiments, a
fixing holding member 25 is installed halfway through theoptical paths fixing holding member 25 can restrict the areas of thetorsion portions optical paths optical paths - The present invention is industrially available, since it provides an optical rotary probe with a simple structure and with excellent reliability.
Claims (7)
1. An optical rotary probe for directing light to an object to be measured and receiving light returned from the object to be measured, the optical rotary probe comprising:
an optical waveguide for transmitting light from a light source;
a mirror member for reflecting the light transmitted through the optical waveguide; and
a rotational oscillation mechanism for rotatably oscillating the mirror member and a tip end portion of the optical waveguide about a longitudinal axis of the optical waveguide;
wherein the rotational oscillation mechanism is adapted to perform the rotational oscillation within a range defined by a torsional elasticity limit of the optical waveguide.
2. The optical rotary probe according to claim 1 , wherein a fixing holding member for restricting the torsional range is provided halfway through the optical waveguide.
3. The optical rotary probe according to claim 1 , wherein a sag is provided in the torsionally oscillating portion of the optical waveguide.
4. The optical rotary probe according to claim 1 , wherein measurement is performed within a constant speed interval of the torsional oscillation while no measurement is performed within a non-constant speed interval.
5. The optical rotary probe according to claim 1 , wherein a second optical waveguide is further provided for transmitting return light from the object to be measured.
6. The optical rotary probe according to claim 5 , wherein the respective optical waveguides are housed in a single bendable flexible member.
7. The optical rotary probe according to claim 6 , wherein the rotational oscillation mechanism is adapted to integrally rotatably oscillate the respective optical waveguides with respect to the bendable flexible member.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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JPP2008-269491 | 2008-10-20 | ||
JP2008269491 | 2008-10-20 | ||
JP2008-269491 | 2008-10-20 | ||
PCT/JP2009/065803 WO2010047190A1 (en) | 2008-10-20 | 2009-09-10 | Rotary optical probe |
Publications (2)
Publication Number | Publication Date |
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US20120008898A1 true US20120008898A1 (en) | 2012-01-12 |
US8602975B2 US8602975B2 (en) | 2013-12-10 |
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Application Number | Title | Priority Date | Filing Date |
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US13/125,176 Active 2030-04-11 US8602975B2 (en) | 2008-10-20 | 2009-09-10 | Optical rotary probe |
Country Status (4)
Country | Link |
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US (1) | US8602975B2 (en) |
JP (1) | JP5477294B2 (en) |
CN (1) | CN102176854B (en) |
WO (1) | WO2010047190A1 (en) |
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JP5549460B2 (en) * | 2010-07-26 | 2014-07-16 | コニカミノルタ株式会社 | Probe driving device and probe |
JP5594833B2 (en) * | 2010-09-30 | 2014-09-24 | パナソニック デバイスSunx株式会社 | Spectroscopic analyzer |
CN102697473A (en) * | 2012-01-18 | 2012-10-03 | 广州宝胆医疗器械科技有限公司 | Integrated optical coherence tomography (OCT) hard ventriculoscope system |
CN102697462A (en) * | 2012-01-18 | 2012-10-03 | 广州宝胆医疗器械科技有限公司 | Integrated OCT (optical coherence tomography) rigid percutaneous nephroscopy system |
CN102697454A (en) * | 2012-01-18 | 2012-10-03 | 广州宝胆医疗器械科技有限公司 | OCT (optical coherence tomography) electronic esophagoscopy system |
CN102697474A (en) * | 2012-01-18 | 2012-10-03 | 广州宝胆医疗器械科技有限公司 | Integral OCT (optical coherence tomography) hard cholecystoscope system |
US10022187B2 (en) * | 2013-12-19 | 2018-07-17 | Novartis Ag | Forward scanning-optical probes, circular scan patterns, offset fibers |
CN106289055B (en) * | 2015-06-05 | 2019-02-15 | 安达满纳米奇精密宝石有限公司 | Gauge in optical profile type |
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- 2009-09-10 WO PCT/JP2009/065803 patent/WO2010047190A1/en active Application Filing
- 2009-09-10 US US13/125,176 patent/US8602975B2/en active Active
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Also Published As
Publication number | Publication date |
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CN102176854A (en) | 2011-09-07 |
JPWO2010047190A1 (en) | 2012-03-22 |
JP5477294B2 (en) | 2014-04-23 |
US8602975B2 (en) | 2013-12-10 |
WO2010047190A1 (en) | 2010-04-29 |
CN102176854B (en) | 2014-02-26 |
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