US20120095522A1 - Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device - Google Patents

Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device Download PDF

Info

Publication number
US20120095522A1
US20120095522A1 US13/329,745 US201113329745A US2012095522A1 US 20120095522 A1 US20120095522 A1 US 20120095522A1 US 201113329745 A US201113329745 A US 201113329745A US 2012095522 A1 US2012095522 A1 US 2012095522A1
Authority
US
United States
Prior art keywords
peak
disc
degenerative disc
disc disease
approximately
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/329,745
Inventor
Bruce J. Simon
Jean C. Gan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EBI LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US13/329,745 priority Critical patent/US20120095522A1/en
Publication of US20120095522A1 publication Critical patent/US20120095522A1/en
Assigned to EBI, L.P. reassignment EBI, L.P. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GAN, JEAN C., SIMON, BRUCE J.
Assigned to EBI, LLC reassignment EBI, LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: EBI, L.P.
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Definitions

  • This invention relates to methods for treating degenerative disc disease, and more particularly to methods for treating degenerative disc disease noninvasively.
  • Degenerative disc disease an irreversible process, is the most common cause of back pain.
  • the intervertebral disc consists of a gelatinous nucleus pulposus encapsulated by a fibrous annulus fibrosus and the end-plates.
  • the nucleus pulposus plays an important role in weight transmission.
  • the nucleus pulposus is pressurized deforming to establish an equilibrating pressure between the annulus fibrosus and vertebral end-plates.
  • the tissue loses its gel-like properties becoming less hydrated and ultimately more fibrous. It is thus less able to transmit the load by exerting pressure on the annulus fibrosus.
  • Anti-neuralgic and anti-inflammatory methods treat the symptoms but do not eliminate the problem.
  • Minimally invasive percutaneous treatments such as those identified above temporarily improve the symptoms, but they do not prevent the progression of DDD and may even accelerate it in the long term.
  • Major surgeries such as those identified above eliminate structures, risk nerve injury during the operation, also risk morbidity, and may result in accelerated disc degeneration at adjacent segments in the long term.
  • the present invention provides for treatment of degenerative disc disease as a new indication for capacitively coupled electrical stimulation.
  • a subject diagnosed as having degenerative disc disease is treated by placing first and second electrodes on the subject's body at the site of an identified disc in a state of degenerative disc disease, and applying an electric field to the identified disc via the first and second electrodes with the intent to treat the degenerative disc disease.
  • the electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0.1 to 20 volts peak-to-peak.
  • Treatment in accordance with the invention regenerates the intervertebral disc or prevents further degeneration of the disc and thus restores the mechanical properties of the spine or reduces pain resulting from disc degeneration (e.g., discogenic pain).
  • the device may be used as an adjunct to other treatments such as implantation of cells (e.g., stem cells from various sources and intervertebral disc cells), biological factors (e.g., growth factors, peptides), scaffolds or materials (e.g., collagen, polymers, ceramics) and gene therapy.
  • cells e.g., stem cells from various sources and intervertebral disc cells
  • biological factors e.g., growth factors, peptides
  • scaffolds or materials e.g., collagen, polymers, ceramics
  • the present invention is a noninvasive and simple approach to relieving pain associated with the disc. It is simple to use, surgery is not required, the treatment can be administered early to prevent further progression of DDD, and it may regenerate the disc. Regeneration of the disc restores the mechanical properties of the spine, and thus, unlike other treatments such as spinal fusions, the present invention will not cause accelerated disc degeneration at adjacent segments in the long term.
  • FIG. 1 is a rear view of the lower torso of a human subject with a pair of electrodes disposed on the skin proximate to the spine for treatment of degenerative disc disease according to one embodiment of the present invention.
  • FIG. 2 is a cross-sectional view of the portion of the spine proximate to the skin electrodes of FIG. 1 .
  • the present invention provides a new method of treating degenerative disc disease (DDD) by using a noninvasive capacitively coupled electrical stimulation device that is compact, light and easy to use, and yet highly effective in operation.
  • two or more electrodes e.g., electrodes 10 and 12 in FIGS. 1 and 2
  • an electrode may be placed on either side of the spine at the level of a disc to be treated, with spacing of 4′′ to 6′′ between the electrodes.
  • Suitable electrodes include those used with the SpinalPak spinal fusion stimulator, commercially available from EBI, L.P.
  • the electrodes are connected to a signal generator which emits a signal with a frequency of 20 to 100 kHz and having a symmetrical waveform with an amplitude of 0.1 to 20 volts peak-to-peak.
  • signals are described in patent application Ser. No. 10/041,850, entitled Non-Invasive Capacitively Coupled Electrical Stimulation Device For Treatment Of Soft Tissue Wounds, filed Jan. 7, 2002 in the name of Jean C. Gan et al., which application is assigned to the assignee of the present invention and incorporated herein by reference.
  • One preferred form of the signal is a symmetrical sine wave with a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.
  • a bipolar DC signal with a symmetrical step or a triangular waveform may be useful in certain applications of the present invention.
  • the signal is preferably applied intermittently but may be applied continuously for a period of time.
  • the invention promotes disc tissue regeneration and/or inhibits further progression of DDD by enhancing the proliferation and matrix synthesis of chondrocytes and stimulating the production of inflammatory cytokine antagonists, such as TGF- ⁇ .
  • the invention may be used as an adjunct to other treatments such as implantation of cells, biological factors, scaffolds or materials, and gene therapy.
  • additional patents and publications are hereby incorporated by reference along with all references cited therein: U.S. Pat. Nos. 4,467,808 and 4,535,775 to Brighton et al.; International Application No.

Abstract

A method for treatment of degenerative disc disease using capacitively coupled electrical stimulation. In one embodiment, a subject diagnosed as having degenerative disc disease is treated by placing first and second electrodes on the subject's body at the site of an identified disc in a state of degenerative disc disease, and applying an electric field to the identified disc via the first and second electrodes with the intent to treat the degenerative disc disease. The electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0.1 to 20 volts peak-to-peak, preferably a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation of application Ser. No. 11/176,588, filed Jul. 7, 2005, now U.S. Pat. No. 8,082,038, issued Dec. 20, 2011, which application claims the benefit of Provisional Patent Application No. 60/586,745, filed Jul. 9, 2004, which applications and patent are hereby incorporated by reference.
    • BACKGROUND OF THE INVENTION
  • This invention relates to methods for treating degenerative disc disease, and more particularly to methods for treating degenerative disc disease noninvasively.
  • Degenerative disc disease (DDD), an irreversible process, is the most common cause of back pain. The intervertebral disc consists of a gelatinous nucleus pulposus encapsulated by a fibrous annulus fibrosus and the end-plates. The nucleus pulposus plays an important role in weight transmission. When this gel-like fluid is subjected to load, the nucleus pulposus is pressurized deforming to establish an equilibrating pressure between the annulus fibrosus and vertebral end-plates. However, with maturation, the tissue loses its gel-like properties becoming less hydrated and ultimately more fibrous. It is thus less able to transmit the load by exerting pressure on the annulus fibrosus. As a result, the annulus fibrosus undergoes greater deformation, and a greater share of the vertical load is borne directly by the annulus fibrosus. These changes result in the development of cracks and cavities within the annulus fibrosus leading to degeneration.
  • There are 3 therapeutic approaches to date:
  • 1) Anti-neuralgic and anti-inflammatory;
  • 2) Minimally invasive percutaneous treatments such as discectomy, intradiscal electrothermy, nucleoplasty and percutaneous radiofrequency application; and
  • 3) Major surgeries such as fusions, laminectomy and nucleus/disc replacements.
  • Anti-neuralgic and anti-inflammatory methods treat the symptoms but do not eliminate the problem. Minimally invasive percutaneous treatments such as those identified above temporarily improve the symptoms, but they do not prevent the progression of DDD and may even accelerate it in the long term. Major surgeries such as those identified above eliminate structures, risk nerve injury during the operation, also risk morbidity, and may result in accelerated disc degeneration at adjacent segments in the long term.
    • SUMMARY OF THE INVENTION
  • The present invention provides for treatment of degenerative disc disease as a new indication for capacitively coupled electrical stimulation. According to one aspect of the present invention, a subject diagnosed as having degenerative disc disease is treated by placing first and second electrodes on the subject's body at the site of an identified disc in a state of degenerative disc disease, and applying an electric field to the identified disc via the first and second electrodes with the intent to treat the degenerative disc disease. The electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0.1 to 20 volts peak-to-peak.
  • Treatment in accordance with the invention regenerates the intervertebral disc or prevents further degeneration of the disc and thus restores the mechanical properties of the spine or reduces pain resulting from disc degeneration (e.g., discogenic pain). The device may be used as an adjunct to other treatments such as implantation of cells (e.g., stem cells from various sources and intervertebral disc cells), biological factors (e.g., growth factors, peptides), scaffolds or materials (e.g., collagen, polymers, ceramics) and gene therapy.
  • Among other advantages of the present invention, it is a noninvasive and simple approach to relieving pain associated with the disc. It is simple to use, surgery is not required, the treatment can be administered early to prevent further progression of DDD, and it may regenerate the disc. Regeneration of the disc restores the mechanical properties of the spine, and thus, unlike other treatments such as spinal fusions, the present invention will not cause accelerated disc degeneration at adjacent segments in the long term.
  • These and other objects and advantages of the present invention will be more apparent upon reading the following detailed description in conjunction with the accompanying drawings.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a rear view of the lower torso of a human subject with a pair of electrodes disposed on the skin proximate to the spine for treatment of degenerative disc disease according to one embodiment of the present invention.
  • FIG. 2 is a cross-sectional view of the portion of the spine proximate to the skin electrodes of FIG. 1.
    •  DESCRIPTION OF PREFERRED EMBODIMENTS
  • For the purpose of promoting an understanding of the principles of the invention, reference will now be made to the embodiments illustrated in the drawings and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, such alterations and further modifications in the illustrated device and such further applications of the principles of the invention as illustrated therein being contemplated as would normally occur to one skilled in the art to which the invention relates.
  • The present invention provides a new method of treating degenerative disc disease (DDD) by using a noninvasive capacitively coupled electrical stimulation device that is compact, light and easy to use, and yet highly effective in operation. In the method according to one aspect of the present invention, two or more electrodes, e.g., electrodes 10 and 12 in FIGS. 1 and 2, are applied noninvasively on the skin at the site of pain or location of the intervertebral disc to be treated. For example, an electrode may be placed on either side of the spine at the level of a disc to be treated, with spacing of 4″ to 6″ between the electrodes. Suitable electrodes include those used with the SpinalPak spinal fusion stimulator, commercially available from EBI, L.P.
  • The electrodes are connected to a signal generator which emits a signal with a frequency of 20 to 100 kHz and having a symmetrical waveform with an amplitude of 0.1 to 20 volts peak-to-peak. Examples of signals are described in patent application Ser. No. 10/041,850, entitled Non-Invasive Capacitively Coupled Electrical Stimulation Device For Treatment Of Soft Tissue Wounds, filed Jan. 7, 2002 in the name of Jean C. Gan et al., which application is assigned to the assignee of the present invention and incorporated herein by reference. One preferred form of the signal is a symmetrical sine wave with a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak. A bipolar DC signal with a symmetrical step or a triangular waveform may be useful in certain applications of the present invention. The signal is preferably applied intermittently but may be applied continuously for a period of time.
  • While the invention is not limited to any one theory of operation, it is believed that the invention promotes disc tissue regeneration and/or inhibits further progression of DDD by enhancing the proliferation and matrix synthesis of chondrocytes and stimulating the production of inflammatory cytokine antagonists, such as TGF-β. As indicated above, the invention may be used as an adjunct to other treatments such as implantation of cells, biological factors, scaffolds or materials, and gene therapy. The following additional patents and publications are hereby incorporated by reference along with all references cited therein: U.S. Pat. Nos. 4,467,808 and 4,535,775 to Brighton et al.; International Application No. PCT/US01/05991 in the name of Brighton et al.; Brighton Carl T., et al., “Treatment of Castration-Induced Osteoporosis by a Capacitively Coupled Electrical Signal in Rat Vertebrae,” J. Bone and Joint Surg., 71-A: 228-236, 1989; Brighton, Carl T., et al., “Treatment of Denervation/Disuse Osteoporosis in the Rat with a Capacitively Coupled Electrical Signal: Effects on Bone Formation and Bone Resorption,” J. Orthop. Res., 6:676-684, 1988.
  • While the invention has been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it being understood that only preferred embodiments have been shown and described and that all changes and modifications that come within the spirit of the invention are desired to be protected.

Claims (24)

1. A nonsurgical method of treating degenerative disc disease, comprising:
identifying an unfused disc in a state of degenerative disc disease in a subject; and
nonsurgically treating the degenerative disc disease by applying capacitively coupled electrical stimulation to the identified unfused disc, intending to promote generation of disc tissue as an alternative to spinal fusion, the electrical stimulation characterized by an electric field created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0.1 to 20 volts peak-to-peak.
2. The method of claim 1, wherein said electrical signal has a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.
3. The method of claim 2, wherein said electrical signal is a sine wave.
4. The method of claim 2, wherein said electrical signal is a bipolar DC signal with a square waveform.
5. The method of claim 2, wherein said electrical signal is a bipolar DC signal with a triangular waveform.
6. A nonsurgical method of treating degenerative disc disease, comprising:
placing first and second electrodes on the body of a subject at the site of a disc in a state of degenerative disc disease; and
applying an electric field to said disc noninvasively via said first and second electrodes as an alternative, not an adjunct, to spinal fusion.
7. The method of claim 6, wherein said electric field is created by supplying a voltage across said electrodes at a frequency within a range of 20 to 100 kHz and an amplitude within a range of 0.1 to 20 volts peak-to-peak.
8. The method of claim 7, wherein said frequency is approximately 60 kHz and said amplitude is approximately 5 volts peak-to-peak.
9. The method of claim 8, wherein said voltage is sinusoidal.
10. The method of claim 8, wherein said voltage is a square wave.
11. The method of claim 8, wherein said voltage is a triangular wave.
12. A nonsurgical method of treating degenerative disc disease, comprising applying capacitively coupled electrical stimulation to a human intervertebral disc in a state of degenerative disc disease untreated by spinal fusion surgery.
13. The method of claim 12, wherein said electrical stimulation is characterized by an electric field created with an electrical signal which has a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.
14. The method of claim 13, wherein said electrical signal is a sine wave.
15. The method of claim 13, wherein said electrical signal is a bipolar DC signal with a square waveform.
16. The method of claim 13, wherein said electrical signal is a bipolar DC signal with a triangular waveform.
17. A nonsurgical method of treating degenerative disc disease, comprising applying capacitively coupled electrical stimulation to a human intervertebral disc in a state of degenerative disc disease between two adjacent vertebrae which are capable of substantially normal relative motion.
18. A nonsurgical method of treating degenerative disc disease, comprising applying capacitively coupled electrical stimulation to a human intervertebral disc in a state of degenerative disc disease, wherein said disc is in a structurally native state between two adjacent vertebrae which are unconstrained by orthopedic hardware.
19. A method of treating degenerative disc disease, comprising:
placing first and second electrodes on the body of a subject at the site of an identified disc in a state of degenerative disc disease; and
applying an electric field to said disc via said first and second electrodes, intending to promote generation of disc tissue.
20. The method of claim 19, wherein said electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and an amplitude within a range of 0.1 to 20 volts peak-to-peak.
21. The method of claim 20, wherein said frequency is approximately 60 kHz and said amplitude is approximately 5 volts peak-to-peak.
22. A nonsurgical method of treatment for degenerative disc disease, comprising providing a capacitively coupled electrical stimulation device for application to a human intervertebral disc in a state of degenerative disc for treatment thereof with electrical stimulation as an alternative, not an adjunct, to spinal fusion.
23. The method of claim 22, wherein said electrical stimulation is characterized by an electric field created with an electrical signal having a frequency within a range of 20 to 100 kHz and an amplitude within a range of 0.1 to 20 volts peak-to-peak.
24. The method of claim 23, wherein said frequency is approximately 60 kHz and said amplitude is approximately 5 volts peak-to-peak.
US13/329,745 2004-07-09 2011-12-19 Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device Abandoned US20120095522A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/329,745 US20120095522A1 (en) 2004-07-09 2011-12-19 Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58674504P 2004-07-09 2004-07-09
US11/176,588 US8082038B2 (en) 2004-07-09 2005-07-07 Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
US13/329,745 US20120095522A1 (en) 2004-07-09 2011-12-19 Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/176,588 Continuation US8082038B2 (en) 2004-07-09 2005-07-07 Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device

Publications (1)

Publication Number Publication Date
US20120095522A1 true US20120095522A1 (en) 2012-04-19

Family

ID=35758412

Family Applications (2)

Application Number Title Priority Date Filing Date
US11/176,588 Active 2026-08-16 US8082038B2 (en) 2004-07-09 2005-07-07 Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
US13/329,745 Abandoned US20120095522A1 (en) 2004-07-09 2011-12-19 Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US11/176,588 Active 2026-08-16 US8082038B2 (en) 2004-07-09 2005-07-07 Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device

Country Status (1)

Country Link
US (2) US8082038B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108031002A (en) * 2018-02-08 2018-05-15 中国医科大学附属盛京医院 For promoting the regenerated electrical stimulation apparatus of autotransplantation fat flap
US10363137B2 (en) 2006-12-05 2019-07-30 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US11395919B1 (en) 2021-02-05 2022-07-26 Theragen, Inc. Therapeutic stimulator system

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120035683A1 (en) * 2004-07-09 2012-02-09 Simon Bruce J Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
US8082038B2 (en) * 2004-07-09 2011-12-20 Ebi, Llc Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
US20070073354A1 (en) * 2005-09-26 2007-03-29 Knudson Mark B Neural blocking therapy
US8868177B2 (en) * 2009-03-20 2014-10-21 ElectroCore, LLC Non-invasive treatment of neurodegenerative diseases
US8577469B2 (en) * 2006-07-12 2013-11-05 Rainbow Medical Ltd. Iontophoretic and electroosmotic disc treatment
US20090204173A1 (en) 2007-11-05 2009-08-13 Zi-Ping Fang Multi-Frequency Neural Treatments and Associated Systems and Methods
US7890182B2 (en) 2008-05-15 2011-02-15 Boston Scientific Neuromodulation Corporation Current steering for an implantable stimulator device involving fractionalized stimulation pulses
US9327121B2 (en) 2011-09-08 2016-05-03 Nevro Corporation Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods
US8255057B2 (en) 2009-01-29 2012-08-28 Nevro Corporation Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions
AU2013205599B2 (en) * 2009-04-22 2013-11-14 Nevro Corporation Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
EP2421600B1 (en) 2009-04-22 2014-03-05 Nevro Corporation Spinal cord modulation systems for inducing paresthetic and anesthetic effects
AU2015201052B2 (en) * 2009-04-22 2017-04-13 Nevro Corporation Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
ES2624748T3 (en) 2009-04-22 2017-07-17 Nevro Corporation Selective high frequency modulation of the spinal cord for pain inhibition with reduced side effects, and associated systems and methods
US8498710B2 (en) 2009-07-28 2013-07-30 Nevro Corporation Linked area parameter adjustment for spinal cord stimulation and associated systems and methods
US8649874B2 (en) 2010-11-30 2014-02-11 Nevro Corporation Extended pain relief via high frequency spinal cord modulation, and associated systems and methods
WO2013148334A1 (en) * 2012-03-27 2013-10-03 Parcell Laboratories, Llc Intervertebral disc repair compositions and methods
US8676331B2 (en) 2012-04-02 2014-03-18 Nevro Corporation Devices for controlling spinal cord modulation for inhibiting pain, and associated systems and methods, including controllers for automated parameter selection
US9833614B1 (en) 2012-06-22 2017-12-05 Nevro Corp. Autonomic nervous system control via high frequency spinal cord modulation, and associated systems and methods
US9731122B2 (en) * 2013-04-29 2017-08-15 Rainbow Medical Ltd. Electroosmotic tissue treatment
US9895539B1 (en) 2013-06-10 2018-02-20 Nevro Corp. Methods and systems for disease treatment using electrical stimulation
US10149978B1 (en) 2013-11-07 2018-12-11 Nevro Corp. Spinal cord modulation for inhibiting pain via short pulse width waveforms, and associated systems and methods
US9616221B2 (en) 2015-07-08 2017-04-11 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease
US11318310B1 (en) 2015-10-26 2022-05-03 Nevro Corp. Neuromodulation for altering autonomic functions, and associated systems and methods
US10898716B2 (en) 2015-10-29 2021-01-26 Rainbow Medical Ltd. Electrical substance clearance from the brain
US9724515B2 (en) 2015-10-29 2017-08-08 Rainbow Medical Ltd. Electrical substance clearance from the brain for treatment of Alzheimer's disease
US9950156B2 (en) 2016-09-13 2018-04-24 Rainbow Medical Ltd. Disc therapy
US9770591B2 (en) 2015-12-29 2017-09-26 Rainbow Medical Ltd. Disc therapy
US11484706B2 (en) 2015-12-29 2022-11-01 Discure Technologies Ltd Disc therapy
US10518085B2 (en) 2015-12-29 2019-12-31 Rainbow Medical Ltd. Disc therapy
AU2017211121B2 (en) 2016-01-25 2022-02-24 Nevro Corp. Treatment of congestive heart failure with electrical stimulation, and associated systems and methods
US10799701B2 (en) 2016-03-30 2020-10-13 Nevro Corp. Systems and methods for identifying and treating patients with high-frequency electrical signals
US11446504B1 (en) 2016-05-27 2022-09-20 Nevro Corp. High frequency electromagnetic stimulation for modulating cells, including spontaneously active and quiescent cells, and associated systems and methods
US10569086B2 (en) 2017-01-11 2020-02-25 Rainbow Medical Ltd. Electrical microglial cell activation
US10758722B2 (en) 2017-05-03 2020-09-01 Rainbow Medical Ltd. Electrical treatment of Parkinson's disease
EP3765141A1 (en) 2018-03-14 2021-01-20 Rainbow Medical Ltd. Electrical substance clearance from the brain
WO2020150647A1 (en) 2019-01-17 2020-07-23 Nevro Corp. Sensory threshold and/or adaptation for neurological therapy screening and/or parameter selection, and associated systems and methods
US11590352B2 (en) 2019-01-29 2023-02-28 Nevro Corp. Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods
US11123197B2 (en) 2019-09-03 2021-09-21 Rainbow Medical Ltd. Hydropneumatic artificial intervertebral disc
US10881858B1 (en) 2019-09-18 2021-01-05 Rainbow Medical Ltd. Electrical substance clearance from the brain
US11298530B1 (en) 2021-05-03 2022-04-12 Discure Technologies Ltd. Synergistic therapies for intervertebral disc degeneration
US11344721B1 (en) 2021-08-16 2022-05-31 Rainbow Medical Ltd. Cartilage treatment
US11413455B1 (en) 2022-02-08 2022-08-16 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535775A (en) * 1983-02-10 1985-08-20 Biolectron, Inc. Method for treatment of non-union bone fractures by non-invasive electrical stimulation
US5792209A (en) * 1996-04-01 1998-08-11 Varner; Lawrence Norman Osteoporosis-relief device
US7130692B2 (en) * 2000-02-23 2006-10-31 The Trustees Of The University Of Pennsylvania Portable electrotherapy device for treating osteoarthritis and other diseases, defects and injuries of the knee joint
US7215995B2 (en) * 2003-11-14 2007-05-08 The Trustees Of The University Of Pennsylvania Method and device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip
US8082038B2 (en) * 2004-07-09 2011-12-20 Ebi, Llc Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4019510A (en) * 1975-02-10 1977-04-26 Sybron Corporation Therapeutic method of using low intensity direct current generator with polarity reversal
US4461300A (en) * 1982-01-18 1984-07-24 Sutter Biomedical, Inc. Bone and tissue healing device including a special electrode assembly and method
US4487834A (en) * 1982-09-17 1984-12-11 Biolectron, Inc. Electrical stimulation of articular chondrocytes
US4467808A (en) * 1982-09-17 1984-08-28 Biolectron, Inc. Method for preventing and treating osteoporosis in a living body by using electrical stimulation non-invasively
US4738250A (en) * 1985-10-01 1988-04-19 Mems Technology, Incorporated Apparatus and method for micro-electric medical stimulation of cells of living animal tissue
US5014699A (en) * 1986-05-23 1991-05-14 Trustees Of The University Of Pennsylvania Electromagnetic method and apparatus for healing living tissue
US5117826A (en) * 1987-02-02 1992-06-02 Staodyn, Inc. Combined nerve fiber and body tissue stimulation apparatus and method
US4846181A (en) * 1987-10-02 1989-07-11 Staodynamics, Inc. Soft tissue wound healing therapy utilizing pulsed electrical stimulation
SE467196B (en) * 1987-11-13 1992-06-15 Bjoern Nordenstroem DEVICE TO APPLY ELECTRICAL ENERGY TO BIOLOGICAL WEAVE TO SIMULATE THE PHYSIOLOGICAL HEALING PROCESS
US4895154A (en) * 1988-02-19 1990-01-23 Staodynamics, Inc. Electronic stimulating device for enhanced healing of soft tissue wounds
US5038780A (en) * 1988-04-29 1991-08-13 The Biotronics Research Corp. Method and apparatus for capacitively regenerating tissue and bone
US4993413A (en) * 1988-09-22 1991-02-19 The Research Foundation Of State University Of New York Method and apparatus for inducing a current and voltage in living tissue
US4982742A (en) * 1989-02-22 1991-01-08 C&Y Technology, Inc. Apparatus and method to facilitate healing of soft tissue wounds
US5107835A (en) * 1989-05-22 1992-04-28 Physiodynamics Electrotherapeutic treatment
US5158081A (en) * 1991-05-29 1992-10-27 Trillion Medical Resources, Inc. Method for treatment of soft tissue wounds by electrical stimulation
US5370680A (en) * 1992-05-27 1994-12-06 Magnetic Resonance Therapeutics, Inc. Athermapeutic apparatus employing electro-magnetic fields
US5395398A (en) * 1993-07-28 1995-03-07 C. R. Bard, Inc. Microelectric apparatus for the antisepsis, promulgation of healing and analgesia of wound and chronic skin ulcers
US5433735A (en) * 1993-09-27 1995-07-18 Zanakis; Michael F. Electrical stimulation technique for tissue regeneration
US5458626A (en) * 1993-12-27 1995-10-17 Krause; Horst E. Method of electrical nerve stimulation for acceleration of tissue healing
US5788682A (en) * 1995-04-28 1998-08-04 Maget; Henri J.R. Apparatus and method for controlling oxygen concentration in the vicinity of a wound
US5814094A (en) * 1996-03-28 1998-09-29 Becker; Robert O. Iontopheretic system for stimulation of tissue healing and regeneration
US5607461A (en) * 1995-10-20 1997-03-04 Nexmed, Inc. Apparatus and method for delivering electrical stimulus to tissue
US6083250A (en) * 1995-10-20 2000-07-04 Nexmed, Inc. Apparatus and method for inhibiting lesion formation by selectively treating the prodromal stage of the lesion with a pulsatile electrical stimulation
US5738521A (en) * 1996-07-19 1998-04-14 Biolectron, Inc. Method for accelerating osseointegration of metal bone implants using electrical stimulation
US6132362A (en) * 1996-11-01 2000-10-17 Amei Technologies, Inc. Pulsed electromagnetic field (PEMF) stimulation therapy system with bi-phasic coil
US5861016A (en) * 1997-05-28 1999-01-19 Swing; Fred P. Method of wound healing using electrical stimulation and acupuncture needles
US5974342A (en) * 1997-10-16 1999-10-26 Electrologic Of America, Inc. Electrical stimulation therapy method and apparatus
CA2295134A1 (en) * 1998-01-15 1999-07-22 Amethyst Technologies, Inc. Improved pulsed electromagnetic energy treatment apparatus and method
US6016450A (en) * 1998-07-02 2000-01-18 Crock; Leander Method and apparatus for stimulating the healing of living tissue using aura therapy
US6132357A (en) * 1998-07-13 2000-10-17 Sabuda; Thomas J. Method of energizing and using an object for stimulating biological processes
US6048301A (en) * 1998-07-13 2000-04-11 Sabuda; Thomas J. Method and device for stimulating biological processes
US20020087155A1 (en) * 1999-08-30 2002-07-04 Underwood Ronald A. Systems and methods for intradermal collagen stimulation
US7465566B2 (en) 2000-02-23 2008-12-16 The Trustees Of The University Of Pennsylvania Regulation of genes via application of specific and selective electrical and electromagnetic signals
WO2003004092A2 (en) * 2001-07-03 2003-01-16 The Trustees Of The University Of Pennsylvania Device and method for electrically inducing osteogenesis in the spine
US7010353B2 (en) * 2002-01-07 2006-03-07 Ebi, L.P. Non-invasive capacitively coupled electrical stimulation device for treatment of soft tissue wounds
US6899667B2 (en) * 2002-10-21 2005-05-31 Paul F. Becker Method and apparatus for the treatment of physical and mental disorders with low frequency, low flux density magnetic fields

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535775A (en) * 1983-02-10 1985-08-20 Biolectron, Inc. Method for treatment of non-union bone fractures by non-invasive electrical stimulation
US5792209A (en) * 1996-04-01 1998-08-11 Varner; Lawrence Norman Osteoporosis-relief device
US7130692B2 (en) * 2000-02-23 2006-10-31 The Trustees Of The University Of Pennsylvania Portable electrotherapy device for treating osteoarthritis and other diseases, defects and injuries of the knee joint
US7215995B2 (en) * 2003-11-14 2007-05-08 The Trustees Of The University Of Pennsylvania Method and device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip
US8082038B2 (en) * 2004-07-09 2011-12-20 Ebi, Llc Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10363137B2 (en) 2006-12-05 2019-07-30 Valtech Cardio, Ltd. Implantation of repair devices in the heart
CN108031002A (en) * 2018-02-08 2018-05-15 中国医科大学附属盛京医院 For promoting the regenerated electrical stimulation apparatus of autotransplantation fat flap
US11395919B1 (en) 2021-02-05 2022-07-26 Theragen, Inc. Therapeutic stimulator system
US11426574B1 (en) 2021-02-05 2022-08-30 Theragen, Inc. Systems, methods and devices for electrical stimulation therapy
US11717685B2 (en) 2021-02-05 2023-08-08 Theragen, Inc. Therapeutic stimulator system
US11759637B2 (en) 2021-02-05 2023-09-19 Theragen, Inc. Systems, methods and devices for electrical stimulation therapy
US11857785B2 (en) 2021-02-05 2024-01-02 Theragen, Inc. Systems, methods and devices for electrical stimulation therapy

Also Published As

Publication number Publication date
US8082038B2 (en) 2011-12-20
US20060030895A1 (en) 2006-02-09

Similar Documents

Publication Publication Date Title
US8082038B2 (en) Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
EP0324163B1 (en) Apparatus for inducing bone growth
US7041309B2 (en) Spinal fusion using an HMG-CoA reductase inhibitor
US7740574B2 (en) Electromagnetic treatment induction apparatus and method for using same
US9101481B2 (en) Subchondral treatment of joint pain of the spine
US20120196251A1 (en) Electrosurgical system and method for treating hard body tissue
US20120197344A1 (en) Electrosurgical system and method for treating hard body tissue
MXPA06005358A (en) Method and device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip.
US20110118852A1 (en) Piezoelectric implant
MXPA03002600A (en) Novel early intervention spinal treatment methods and devices for use therein.
ATE434996T1 (en) USE OF CROSS-LINKED COLLAGEN TO TREAT INTERVERBAL DISCS
Lavine et al. Treatment of congenital pseudarthrosis of the tibia with direct current
US8088084B2 (en) Method and apparatus for repair of intervertebral discs
Perrin et al. Spinal fixation after anterior decompression for symptomatic spinal metastasis
US20060030896A1 (en) Pulsed electromagnetic field method of treatment of degenerative disc disease
US20120035683A1 (en) Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device
GB2255719A (en) Electro-therapy apparatus
WO2008151119A2 (en) Compositions and methods for use of scar tissue in repair of weight bearing surfaces
Albert et al. Electrical stimulation of bone repair
Brentlinger et al. Perforation of the external iliac artery and ureter presenting as acute hemorrhagic cystitis after total hip replacement. Report of a case.
WO2009105606A1 (en) Compositions and methods for use of scar tissue in repair of weight bearing surfaces
Akiyama et al. Low-intensity pulsed ultrasound therapy stimulates callus formation between host femur and cortical onlay strut allograft
Sobol et al. Lasers in orthopaedic surgery
Dal Monte et al. Pulsed electromagnetic field therapy in the treatment of congenital and acquired pseudarthrosis
Snyder et al. Current applications of electrotherapeutics in collagen healing

Legal Events

Date Code Title Description
AS Assignment

Owner name: EBI, L.P., NEW JERSEY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SIMON, BRUCE J.;GAN, JEAN C.;SIGNING DATES FROM 20050907 TO 20050919;REEL/FRAME:031614/0195

Owner name: EBI, LLC, NEW JERSEY

Free format text: CHANGE OF NAME;ASSIGNOR:EBI, L.P.;REEL/FRAME:031648/0503

Effective date: 20080227

STCB Information on status: application discontinuation

Free format text: ABANDONED -- AFTER EXAMINER'S ANSWER OR BOARD OF APPEALS DECISION