US20120183671A1 - Palatinose for enhancing dietary supplement and pharmaceutical delivery - Google Patents
Palatinose for enhancing dietary supplement and pharmaceutical delivery Download PDFInfo
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- US20120183671A1 US20120183671A1 US13/351,747 US201213351747A US2012183671A1 US 20120183671 A1 US20120183671 A1 US 20120183671A1 US 201213351747 A US201213351747 A US 201213351747A US 2012183671 A1 US2012183671 A1 US 2012183671A1
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- palatinose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Definitions
- the present invention relates to a disaccharide for therapeutic use. More particularly, the invention relates to the use of palatinose (6-O-alpha-D-glucopyranosyl-D-fructofuranose) to increase the efficacy of dietary supplements and pharmaceuticals.
- palatinose (6-O-alpha-D-glucopyranosyl-D-fructofuranose)
- Palatinose is a disaccharide consisting of d-glucose and d-fructose connected by an alpha-1,6-glycosidic linkage. It is also referred to as 6-O-alpha-D-glucopyranosyl-D-fructofuranose and as isomaltulose, and is readily produced commercially from sucrose by enzymatic rearrangement. Palatinose has a taste and appearance similar to that of sucrose. Because of the rate by which it is metabolized, it presents potential dietary and therapeutic uses.
- sucrose common table sugar
- insulin levels rise quickly. This is followed by a quick rise in insulin levels which brings the blood glucose level back down.
- the digestion and absorption of palatinose is unlike other sugars. It is completely digested and absorbed at a much slower speed, equivalent to about 1 ⁇ 5 of that for sucrose.
- blood glucose and insulin levels rise more slowly and reach a lower maxima compared to sucrose. Because of this characteristic, palatinose is well suited as a sucrose replacement for diabetics and others with prediabetic dispositions.
- palatinose Another benefit of palatinose is its non-cariogenic quality, i.e., does not promote tooth decay. It is used as a substitute for other sugars, particularly in the candy and chewing gum industry. Moreover, it is an improvement over other sugar-substitutes because it does not cause abdominal discomfort or diarrhea, a side-effect of many sugar alcohols.
- sugar substitutes which are generally sugar alcohols, are also inadequate for purposes of aiding absorption. Although they are hydrolyzed and digested slowly, they often cause abdominal discomfort and diarrhea. Thus, an improved sugar is needed for use in the absorption of dietary supplement products as well as other therapeutic compounds.
- the present invention solves the above-described problem by providing a dietary supplement comprising palatinose or a derivative thereof, a sugar, a stimulant, at least one amino acid or derivative thereof, and at least one mineral.
- the dietary supplement may be a nutritional product, a sports performance product, a weight loss product, or a meal replacement product. Palatinose enhances absorption of the dietary supplement components into the bloodstream, cells and tissue.
- the dietary supplement may comprise palatinose or a derivative thereof; amylose; glucose; a methylxanthine such as caffeine or theobromine or both; arginine or a salt, ester or chelate thereof; creatine or a salt, ester or chelate thereof; disodium adenosine triphosphate; calcium carbonate; sodium bicarbonate; and glucuronolactone.
- This dietary supplement formulation increases the athletic performance of a mammal during an approximately one to three hour period.
- the dietary supplement of the present invention may comprise palatinose or a derivative thereof; trehalose; amylose; amylopectin; L-carnosine; calcium carbonate; sodium bicarbonate; sulbutiamine or fursultiamine; disodium adenosine triphosphate; orotic acid; vinpocetine or rhodiola rosea ; and cellulose or another undigestible bulk forming starch.
- This dietary supplement formulation increases the athletic performance of a mammal during an approximately three to eight hour period.
- Another aspect of the present invention is directed to a method of increasing the absorption of a compound into the bloodstream, cells and tissue.
- the method includes administering palatinose or a derivative thereof in combination with the compound.
- the compound may be a dietary supplement, a nutrient, a pharmaceutical, or a vaccine
- the method may comprise adding palatinose or a derivative thereof to the dietary supplement formulation prior to administration.
- the method may comprise adding palatinose or a derivative thereof to the pharmaceutical formulation.
- another aspect of the present invention is directed to a diluent for parenteral compounds, wherein the diluent comprises palatinose or a derivative thereof.
- the parenteral compound may be a dietary supplement, a nutrient, a pharmaceutical, or a vaccine.
- another aspect of the present invention is directed to a method of decreasing recovery time to pre-performance levels of total adenosine triphosphate (ATP) levels in a mammal comprising administering palatinose, or derivative thereof, to the mammal.
- the palatinose or derivative thereof may be administered orally or parenterally.
- the palatinose or derivative thereof is administered in a dose between about 0.5 grams and about 200 grams.
- the present invention is also directed to a method of supplying a compound to a diabetic patient, burn victim patient or trauma victim patient.
- the method includes administering palatinose, or a derivative thereof, in combination with the compound.
- the compound may be a nutrient, dietary supplement, or pharmaceutical.
- the compound and palatinose or derivative thereof may be administered orally or parenterally.
- the palatinose or derivative thereof is preferably administered in a dose between about 0.5 grams and about 200 grams.
- Palatinose offers an improvement over other sugars, including glucose, in that it is metabolized much slower by the gastrointestinal tract thereby extending the time that the “sugar effect,” both direct and indirect, can have on the absorption of dietary supplements, nutrients, pharmaceuticals or vaccines. Rather than enter the blood stream, rapidly rise and fall, palatinose leads to gradual increases and sustained levels of glucose and insulin. This allows greater time and opportunity for the absorption of various compounds. With respect to dietary supplements, the end result may be greater energy, alertness, athletic performance and/or muscle development.
- palatinose Moreover, replacing common sugars with palatinose presents other advantages. Preventing surges in blood glucose and insulin levels may help in the management and prevention of obesity, diabetes and cardiovascular disease. Recent studies have also provided evidence that palatinose may also have a positive effect on mental concentration. And unlike other sugars, palatinose does not promote tooth decay.
- dietary supplement as any product (except tobacco) that contains at least one of the following: (1) a vitamin, (2) a mineral, (3) an herb or botanical, (4) an amino acid, (5) a dietary substance “for use to supplement the diet by increasing total dietary intake,” or (6) any concentrate, metabolite, constituent, extract, or combination of any of the aforementioned ingredients.
- dietary supplements include, but are not limited to nutritional products; sports performance products, including ergogenic sports performing products; weight loss products; and meal replacement products. Dietary supplements may exist in various forms, including, but not limited to tablets, capsules, caplets, powders, drinks including shakes, solid food items including snack bars, etc.
- the dietary supplement of the present invention includes palatinose or a derivative thereof, a sugar, a stimulant, at least one amino acid or derivative thereof, and at least one mineral.
- a dietary supplement designed to increase the athletic performance of a mammal during a one to three hour sports activity period preferably comprises palatinose or a derivative thereof; amylose; glucose; a methylxanthine such as caffeine or theobromine or both; arginine or a salt, ester or chelate thereof; creatine or a salt, ester or chelate thereof; disodium adenosine triphosphate; calcium carbonate; sodium bicarbonate; and glucuronolactone.
- the dietary supplement of the present invention may comprise palatinose or a derivative thereof; trehalose; amylose; amylopectin; L-carnosine; calcium carbonate; sodium bicarbonate; sulbutiamine or fursultiamine; disodium adenosine phosphate; orotic acid; vinpocetine or rhodiola rosea ; cellulose or another undigestible bulk forming starch; and perhaps at least one B vitamin.
- This dietary supplement formulation increases the athletic performance of a mammal during an approximately three to eight hour period.
- Other preferred dietary supplement formulations of the present invention may comprise palatinose or a derivative thereof, and any or all of the following: water; carbon dioxide; creatine or a salt, ester or chelate thereof; carnitine or a salt, ester or chelate thereof; taurine or a salt, ester or chelate thereof; arginine or a salt, ester or chelate thereof; citrulline or a salt, ester or chelate thereof; carnosine or a salt, ester or chelate thereof; pyruvate or a salt, ester or chelate thereof; ribose; amylase; amylopectin; tyrosine or a salt, ester or chelate thereof; tyramine or a salt, ester or chelate thereof; histidine or a salt, ester or chelate thereof; alanine or a salt, ester or chelate thereof; phenylalanine or a salt, ester or chelate thereof;
- these dietary supplements increase athletic performance, energy, strength, percent fat-free muscle mass, muscle development, mental concentration and alertness, and stamina in mammals.
- palatinose may be added to any dietary supplement formulation to enhance the effects of and improve the absorption of the dietary supplement, and the present invention is intended to encompass such improved formulations. It should also be understood that use of the palatinose in any of the embodiments or methods of the present invention may be substituted by any derivative of palatinose.
- the concentration of palatinose, or derivative thereof, in the dietary supplement is between approximately 1% and approximately 85%. More preferably, the concentration of palatinose in the dietary supplement is between approximately 10% and approximately 50%. Furthermore, the palatinose present in the dietary supplement is desirably administered in a dose between about 0.5 grams and about 200 grams.
- the present invention is also related to a method of increasing the absorption of a compound into the bloodstream, cells and tissue by administering palatinose, or a derivative thereof, in combination with the compound.
- Palatinose may be used to increase the absorption of any compound in the method of the present invention, including compounds used to treat any disease or illness.
- Exemplary compounds for use in the present invention include, but are not limited to a dietary supplement, a nutrient, a pharmaceutical, or a vaccine.
- palatinose maintains a more constant elevation of blood sugar levels as opposed to other sugars, an optimal maximum rate of adenosine triphosphate (ATP) synthesis in cells can be maintained for several hours.
- ATP adenosine triphosphate
- Palatinose maintains a slightly heightened plasma sugar level for a longer period of time.
- mitochondria have access to optimal levels of carbohydrates for approximately 6 to 8 hours, thereby allowing for heightened and continued ATP synthesis.
- the administration of palatinose, or a derivative thereof, to a mammal decreases the recovery time to pre-activity performance levels of total ATP in the mammal.
- palatinose is administered prior to the sports performance.
- the method of the present invention may include adding palatinose, or a derivative thereof, to a dietary supplement formulation, pharmaceutical formulation or vaccine formulation prior to administering the respective compounds.
- concentration of palatinose or derivative thereof, in the dietary supplement, pharmaceutical, vaccine or other formulation is between approximately 1% and approximately 85%. More preferably, the concentration of palatinose or derivative thereof, in the dietary supplement, pharmaceutical, vaccine or other formulation, is between approximately 10% and approximately 50%.
- the palatinose, or derivative thereof is desirably administered in a dose between about 0.5 grams and about 200 grams.
- Additional examples of compounds that may be used in the method of the present invention include, but are not limited to phosphatidyserine; S-adenosyl-methionine; nicotinarnide adenine dinucleotide; any cephalosporin antibiotic; any macrolide antibiotic; any aminoglycoside; antibiotic; any penicillin antibiotic; any fluroquinolone antibiotic; any tetracycline antibiotic; chloramphenicol; any protease inhibitor antiviral; any nucleoside analog antiviral; any reverse transcriptase inhibitor antiviral; any polyene or membrane active antimycotic; any azole or inhibitor of ergosterol biosynthesis antimycotics; griseofulvin; flucytosine; capsofungin; mycafungin; any pneuraminidase inhibitor antiviral; any polymerase inhibitor antiviral; any class of interferon; any class of interleukin; any type of human growth hormone; any type of insulin growth factor or insulin like growth factor; any
- the compound and palatinose may be administered by any method known to those having skill in the art including, but not limited to oral and parenteral administration.
- the compound and palatinose may also be administered in a solution of water or saline, wherein the saline is hypotonic, hypertonic or normotonic saline.
- Palatinose, or a derivative thereof may also be used as a diluent for any parenteral compound, including, but not limited to dietary supplements, nutrients, pharmaceuticals and vaccines.
- Palatinose is particularly useful for supplying any compound, including nutrients and pharmaceuticals, to patients, such as diabetic, burn victim, and trauma victim patients.
Abstract
The present invention is directed to a dietary supplement comprising palatinose or a derivative thereof The dietary supplement may be a nutritional product, a sports performance product, a weight loss product or a meal replacement product. The present invention is also directed to a method of increasing the absorption of a compound into the bloodstream, cells and tissue comprising administering palatinose, or a derivative thereof, in combination with the compound.
Description
- This application is a continuation of U.S. application Ser. No. 12/410,861, filed on Mar. 25, 2009, which is a continuation of U.S. application Ser. No. 11/385,137, filed on Mar. 20, 2006, which claims the benefit of U.S. Provisional Application No. 60/663,384, filed Mar. 19, 2005. The entire teachings of the above applications are incorporated herein by reference.
- 1. Technical Field
- The present invention relates to a disaccharide for therapeutic use. More particularly, the invention relates to the use of palatinose (6-O-alpha-D-glucopyranosyl-D-fructofuranose) to increase the efficacy of dietary supplements and pharmaceuticals.
- 2. Description of Related Art
- Palatinose is a disaccharide consisting of d-glucose and d-fructose connected by an alpha-1,6-glycosidic linkage. It is also referred to as 6-O-alpha-D-glucopyranosyl-D-fructofuranose and as isomaltulose, and is readily produced commercially from sucrose by enzymatic rearrangement. Palatinose has a taste and appearance similar to that of sucrose. Because of the rate by which it is metabolized, it presents potential dietary and therapeutic uses.
- Most sugars are rapidly absorbed after consumption. Therein, after oral administration of a significant amount of sucrose (common table sugar), blood glucose levels rise quickly. This is followed by a quick rise in insulin levels which brings the blood glucose level back down. The digestion and absorption of palatinose is unlike other sugars. It is completely digested and absorbed at a much slower speed, equivalent to about ⅕ of that for sucrose. Thus, after oral administration of palatinose, blood glucose and insulin levels rise more slowly and reach a lower maxima compared to sucrose. Because of this characteristic, palatinose is well suited as a sucrose replacement for diabetics and others with prediabetic dispositions.
- Another benefit of palatinose is its non-cariogenic quality, i.e., does not promote tooth decay. It is used as a substitute for other sugars, particularly in the candy and chewing gum industry. Moreover, it is an improvement over other sugar-substitutes because it does not cause abdominal discomfort or diarrhea, a side-effect of many sugar alcohols.
- Many compounds, including nutrients and dietary supplements, depend on the presence of a sugar for absorption from the gastrointestinal tract as well as for absorption from the plasma into various tissues/cells of the body. Studies have demonstrated that the performance enhancing supplement creatine is better absorbed into human skeletal muscle when taken with glucose. Certain amino acids are also more readily absorbed when administered with glucose. However, sucrose and other sugars are not ideal for use in combination with nutrient supplements. Sucrose is rapidly digested and absorbed into the blood stream. This results in a rapid rise in circulating insulin levels which quickly lowers circulating glucose levels. As a result, many compounds and nutrients administered in combination with sucrose may not be absorbed because of the short duration of the “sugar effect.”
- Moreover, excessive amounts of sugar can cause an increase in body fat, decreased sensitivity to insulin and tooth decay. Sugar substitutes, which are generally sugar alcohols, are also inadequate for purposes of aiding absorption. Although they are hydrolyzed and digested slowly, they often cause abdominal discomfort and diarrhea. Thus, an improved sugar is needed for use in the absorption of dietary supplement products as well as other therapeutic compounds.
- The present invention solves the above-described problem by providing a dietary supplement comprising palatinose or a derivative thereof, a sugar, a stimulant, at least one amino acid or derivative thereof, and at least one mineral. The dietary supplement may be a nutritional product, a sports performance product, a weight loss product, or a meal replacement product. Palatinose enhances absorption of the dietary supplement components into the bloodstream, cells and tissue.
- More particularly, the dietary supplement may comprise palatinose or a derivative thereof; amylose; glucose; a methylxanthine such as caffeine or theobromine or both; arginine or a salt, ester or chelate thereof; creatine or a salt, ester or chelate thereof; disodium adenosine triphosphate; calcium carbonate; sodium bicarbonate; and glucuronolactone. This dietary supplement formulation increases the athletic performance of a mammal during an approximately one to three hour period.
- Still more particularly, the dietary supplement of the present invention may comprise palatinose or a derivative thereof; trehalose; amylose; amylopectin; L-carnosine; calcium carbonate; sodium bicarbonate; sulbutiamine or fursultiamine; disodium adenosine triphosphate; orotic acid; vinpocetine or rhodiola rosea; and cellulose or another undigestible bulk forming starch. This dietary supplement formulation increases the athletic performance of a mammal during an approximately three to eight hour period.
- Another aspect of the present invention is directed to a method of increasing the absorption of a compound into the bloodstream, cells and tissue. The method includes administering palatinose or a derivative thereof in combination with the compound.
- More particularly, the compound may be a dietary supplement, a nutrient, a pharmaceutical, or a vaccine, lithe compound is a dietary supplement formulation, the method may comprise adding palatinose or a derivative thereof to the dietary supplement formulation prior to administration. If the compound is a pharmaceutical formulation, the method may comprise adding palatinose or a derivative thereof to the pharmaceutical formulation.
- Still, another aspect of the present invention is directed to a diluent for parenteral compounds, wherein the diluent comprises palatinose or a derivative thereof. The parenteral compound may be a dietary supplement, a nutrient, a pharmaceutical, or a vaccine.
- Yet, another aspect of the present invention is directed to a method of decreasing recovery time to pre-performance levels of total adenosine triphosphate (ATP) levels in a mammal comprising administering palatinose, or derivative thereof, to the mammal. The palatinose or derivative thereof may be administered orally or parenterally. Preferably, the palatinose or derivative thereof is administered in a dose between about 0.5 grams and about 200 grams.
- The present invention is also directed to a method of supplying a compound to a diabetic patient, burn victim patient or trauma victim patient. The method includes administering palatinose, or a derivative thereof, in combination with the compound. The compound may be a nutrient, dietary supplement, or pharmaceutical. The compound and palatinose or derivative thereof, may be administered orally or parenterally. In addition, the palatinose or derivative thereof is preferably administered in a dose between about 0.5 grams and about 200 grams.
- Other features and advantages of the present invention will become apparent upon reading the following detailed description of embodiments of the invention, when taken in conjunction with the appended claims.
- Studies have demonstrated that the presence of sugar directly enhances nutrient absorption into various tissues and cells. For example, a mixture of arginine and glucose is more efficiently absorbed into the vascular endothelium than arginine alone. Other studies have shown that nutrients and ergogenic sports performance products depend on the indirect presence of sugar for absorption wherein increased levels of insulin enhance the absorption of nutrients into the tissues and cells.
- Palatinose offers an improvement over other sugars, including glucose, in that it is metabolized much slower by the gastrointestinal tract thereby extending the time that the “sugar effect,” both direct and indirect, can have on the absorption of dietary supplements, nutrients, pharmaceuticals or vaccines. Rather than enter the blood stream, rapidly rise and fall, palatinose leads to gradual increases and sustained levels of glucose and insulin. This allows greater time and opportunity for the absorption of various compounds. With respect to dietary supplements, the end result may be greater energy, alertness, athletic performance and/or muscle development.
- Moreover, replacing common sugars with palatinose presents other advantages. Preventing surges in blood glucose and insulin levels may help in the management and prevention of obesity, diabetes and cardiovascular disease. Recent studies have also provided evidence that palatinose may also have a positive effect on mental concentration. And unlike other sugars, palatinose does not promote tooth decay.
- The Dietary Supplement Health and Education Act of 1994, commonly referred to as DSHEA, defines “dietary supplement” as any product (except tobacco) that contains at least one of the following: (1) a vitamin, (2) a mineral, (3) an herb or botanical, (4) an amino acid, (5) a dietary substance “for use to supplement the diet by increasing total dietary intake,” or (6) any concentrate, metabolite, constituent, extract, or combination of any of the aforementioned ingredients. Examples of dietary supplements include, but are not limited to nutritional products; sports performance products, including ergogenic sports performing products; weight loss products; and meal replacement products. Dietary supplements may exist in various forms, including, but not limited to tablets, capsules, caplets, powders, drinks including shakes, solid food items including snack bars, etc.
- In one embodiment, the dietary supplement of the present invention includes palatinose or a derivative thereof, a sugar, a stimulant, at least one amino acid or derivative thereof, and at least one mineral. For example, a dietary supplement designed to increase the athletic performance of a mammal during a one to three hour sports activity period, preferably comprises palatinose or a derivative thereof; amylose; glucose; a methylxanthine such as caffeine or theobromine or both; arginine or a salt, ester or chelate thereof; creatine or a salt, ester or chelate thereof; disodium adenosine triphosphate; calcium carbonate; sodium bicarbonate; and glucuronolactone.
- Alternatively, the dietary supplement of the present invention may comprise palatinose or a derivative thereof; trehalose; amylose; amylopectin; L-carnosine; calcium carbonate; sodium bicarbonate; sulbutiamine or fursultiamine; disodium adenosine phosphate; orotic acid; vinpocetine or rhodiola rosea; cellulose or another undigestible bulk forming starch; and perhaps at least one B vitamin. This dietary supplement formulation increases the athletic performance of a mammal during an approximately three to eight hour period.
- Other preferred dietary supplement formulations of the present invention may comprise palatinose or a derivative thereof, and any or all of the following: water; carbon dioxide; creatine or a salt, ester or chelate thereof; carnitine or a salt, ester or chelate thereof; taurine or a salt, ester or chelate thereof; arginine or a salt, ester or chelate thereof; citrulline or a salt, ester or chelate thereof; carnosine or a salt, ester or chelate thereof; pyruvate or a salt, ester or chelate thereof; ribose; amylase; amylopectin; tyrosine or a salt, ester or chelate thereof; tyramine or a salt, ester or chelate thereof; histidine or a salt, ester or chelate thereof; alanine or a salt, ester or chelate thereof; phenylalanine or a salt, ester or chelate thereof; adenosine mono, di or triphosphate, or a salt, ester or chelate thereof; alpha lipoic acid, or a salt, ester or chelate thereof; 4-hydroxy-isoleucine; d-pinitol; ornithine or a salt, ester or chelate thereof; sodium or any salt thereof; potassium or any salt thereof; zinc or any salt thereof; magnesium or any salt thereof; iron or any salt thereof; chromium or any salt thereof; calcium or any salt thereof; vitamin B-1; vitamin B-2; vitamin B-3; vitamin B-6; vitamin B-12; pantothenic acid; folic acid; vitamin C; 7-keto-DHEA, or any ester or ether thereof; 7-hydroxy-DHEA or any ester thereof; caffeine; octopamine; norsynephrine; synephrine; ephedrine; hordenine; theobromine; evodiamine; phenylephrine; insulin; metformin; corosolic acid; glucuronolactone; ginger; ginseng; ginko biloba; rhodiola rosea; fenugreek; epicatechin; epicatechin-3-gallate; epigallocatechin; epigallocatecin-3-gallate; glutamine; branched chain amino acids or any salts or esters thereof; any chelate of any amino acid; 6-methyluracil; phosphocreatinine; orotic acid; 5-hydroxytryptophan; vinpocetine; sucralose; fructose; galactose; maltodextrin; glucose; DMAE; DMG; TMG; coenzyme Q-10, sulbutiamine; fursultiamine; octotiarnine; adrafanil; choline; phosphatidylcholine; and phosphatidylserine.
- Due to the presence of palatinose, or derivative thereof, in the dietary supplements of the present invention, these dietary supplements increase athletic performance, energy, strength, percent fat-free muscle mass, muscle development, mental concentration and alertness, and stamina in mammals.
- It should be understood that palatinose may be added to any dietary supplement formulation to enhance the effects of and improve the absorption of the dietary supplement, and the present invention is intended to encompass such improved formulations. It should also be understood that use of the palatinose in any of the embodiments or methods of the present invention may be substituted by any derivative of palatinose.
- Preferably, the concentration of palatinose, or derivative thereof, in the dietary supplement is between approximately 1% and approximately 85%. More preferably, the concentration of palatinose in the dietary supplement is between approximately 10% and approximately 50%. Furthermore, the palatinose present in the dietary supplement is desirably administered in a dose between about 0.5 grams and about 200 grams.
- The present invention is also related to a method of increasing the absorption of a compound into the bloodstream, cells and tissue by administering palatinose, or a derivative thereof, in combination with the compound. Palatinose may be used to increase the absorption of any compound in the method of the present invention, including compounds used to treat any disease or illness. Exemplary compounds for use in the present invention include, but are not limited to a dietary supplement, a nutrient, a pharmaceutical, or a vaccine. When palatinose is used to increase the absorption of particular compounds, including dietary supplements and nutrients, the fatigue associated with an athletic performance of a mammal is reduced.
- In addition, because palatinose maintains a more constant elevation of blood sugar levels as opposed to other sugars, an optimal maximum rate of adenosine triphosphate (ATP) synthesis in cells can be maintained for several hours. Most sugars, including glucose, peak in the plasma about 45 to 60 minutes post absorption and then an insulin spike drives this level down rapidly, leading to pre-prandial (or lower) levels of plasma sugar. When the plasma sugar levels decrease. ATP synthesis also decreases. Palatinose maintains a slightly heightened plasma sugar level for a longer period of time. As a result, mitochondria have access to optimal levels of carbohydrates for approximately 6 to 8 hours, thereby allowing for heightened and continued ATP synthesis. Accordingly, the administration of palatinose, or a derivative thereof, to a mammal decreases the recovery time to pre-activity performance levels of total ATP in the mammal. Preferably, palatinose is administered prior to the sports performance.
- The method of the present invention may include adding palatinose, or a derivative thereof, to a dietary supplement formulation, pharmaceutical formulation or vaccine formulation prior to administering the respective compounds. Preferably, the concentration of palatinose or derivative thereof, in the dietary supplement, pharmaceutical, vaccine or other formulation, is between approximately 1% and approximately 85%. More preferably, the concentration of palatinose or derivative thereof, in the dietary supplement, pharmaceutical, vaccine or other formulation, is between approximately 10% and approximately 50%. Furthermore, the palatinose, or derivative thereof, is desirably administered in a dose between about 0.5 grams and about 200 grams.
- Additional examples of compounds that may be used in the method of the present invention include, but are not limited to phosphatidyserine; S-adenosyl-methionine; nicotinarnide adenine dinucleotide; any cephalosporin antibiotic; any macrolide antibiotic; any aminoglycoside; antibiotic; any penicillin antibiotic; any fluroquinolone antibiotic; any tetracycline antibiotic; chloramphenicol; any protease inhibitor antiviral; any nucleoside analog antiviral; any reverse transcriptase inhibitor antiviral; any polyene or membrane active antimycotic; any azole or inhibitor of ergosterol biosynthesis antimycotics; griseofulvin; flucytosine; capsofungin; mycafungin; any pneuraminidase inhibitor antiviral; any polymerase inhibitor antiviral; any class of interferon; any class of interleukin; any type of human growth hormone; any type of insulin growth factor or insulin like growth factor; any type of anti-vascular endothelial growth factor antibodies; any alkylating agent including those used to treat cancer of any type; any antimetabolite agent including those used to treat cancer of any type; any plant alkaloid agent including those used to treat cancer of any type; doxorubicin or any salt, ester, or chelate thereof; mitoxantrone or any salt, ester or chelate thereof; bleomycin or any salt, ester, ether or chelate thereof; platinum or any salt, ester, ether or chelate thereof; paclitaxel; docetaxel; epoeitin alfa; and darboepoeitin alfa.
- The compound and palatinose may be administered by any method known to those having skill in the art including, but not limited to oral and parenteral administration. The compound and palatinose may also be administered in a solution of water or saline, wherein the saline is hypotonic, hypertonic or normotonic saline. Palatinose, or a derivative thereof, may also be used as a diluent for any parenteral compound, including, but not limited to dietary supplements, nutrients, pharmaceuticals and vaccines.
- Palatinose is particularly useful for supplying any compound, including nutrients and pharmaceuticals, to patients, such as diabetic, burn victim, and trauma victim patients.
- It should be understood that the foregoing relates to exemplary embodiments of the invention and that modifications may be made without departing from the spirit and scope of the invention as set forth in the following claims.
Claims (1)
1. A dietary supplement comprising:
palatinose or a derivative thereof;
a sugar;
a stimulant;
at least one amino acid or derivative thereof; and
at least one mineral.
Priority Applications (6)
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US13/351,747 US20120183671A1 (en) | 2005-03-19 | 2012-01-17 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US13/709,763 US20130095125A1 (en) | 2005-03-19 | 2012-12-10 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US15/666,528 US10624915B2 (en) | 2005-03-19 | 2017-08-01 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/785,498 US11103522B2 (en) | 2005-03-19 | 2020-02-07 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/790,667 US20200237792A1 (en) | 2005-03-19 | 2020-02-13 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/824,140 US20200215088A1 (en) | 2005-03-19 | 2020-03-19 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
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US66338405P | 2005-03-19 | 2005-03-19 | |
US11/385,137 US8283327B2 (en) | 2005-03-19 | 2006-03-20 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
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US13/351,747 US20120183671A1 (en) | 2005-03-19 | 2012-01-17 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
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US12/410,861 Continuation US20090181922A1 (en) | 2005-03-19 | 2009-03-25 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
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US12/504,480 Abandoned US20090281055A1 (en) | 2005-03-19 | 2009-07-16 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US13/351,747 Abandoned US20120183671A1 (en) | 2005-03-19 | 2012-01-17 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US13/709,763 Abandoned US20130095125A1 (en) | 2005-03-19 | 2012-12-10 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US15/666,528 Active US10624915B2 (en) | 2005-03-19 | 2017-08-01 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/785,498 Active US11103522B2 (en) | 2005-03-19 | 2020-02-07 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/790,667 Abandoned US20200237792A1 (en) | 2005-03-19 | 2020-02-13 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/824,140 Abandoned US20200215088A1 (en) | 2005-03-19 | 2020-03-19 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
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US12/504,480 Abandoned US20090281055A1 (en) | 2005-03-19 | 2009-07-16 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
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US13/709,763 Abandoned US20130095125A1 (en) | 2005-03-19 | 2012-12-10 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US15/666,528 Active US10624915B2 (en) | 2005-03-19 | 2017-08-01 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/785,498 Active US11103522B2 (en) | 2005-03-19 | 2020-02-07 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/790,667 Abandoned US20200237792A1 (en) | 2005-03-19 | 2020-02-13 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US16/824,140 Abandoned US20200215088A1 (en) | 2005-03-19 | 2020-03-19 | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10624915B2 (en) | 2005-03-19 | 2020-04-21 | Bruce W. Kneller | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006035912A1 (en) * | 2006-07-31 | 2008-02-07 | Südzucker AG Mannheim/Ochsenfurt | Use of isomaltulose in regenerative foods |
US20090005320A1 (en) * | 2008-09-02 | 2009-01-01 | Bruce Kneller | Compositions comprising amino acid bicarbonate and methods of use thereof |
US8703719B1 (en) | 2009-05-18 | 2014-04-22 | Bio-Engineered Supplements And Nutrition, Inc. | Method and composition for improved muscle performance |
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US10881125B1 (en) * | 2016-04-28 | 2021-01-05 | Stephen C. Perry | Taurine-containing composition for improving assimilation of compounds contained in ingestible items |
JP7316035B2 (en) * | 2018-11-15 | 2023-07-27 | Dm三井製糖株式会社 | Drowsiness suppressant and food/beverage for suppressing drowsiness |
CN110433169A (en) * | 2019-08-13 | 2019-11-12 | 复旦大学附属华山医院 | Adenosine is preparing the application in hypoglycemic drug |
WO2023194567A1 (en) * | 2022-04-06 | 2023-10-12 | Dr. Kurt Wolff Gmbh & Co. Kg | Oral composition containing dimethylglycine for improving the condition of the hair and scalp |
WO2023223344A1 (en) * | 2022-05-17 | 2023-11-23 | Fertis India Pvt. Ltd. | Compositions comprising methylxanthines and disaccharides derived from enzymatic conversion of sucrose |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6460360A (en) * | 1987-08-31 | 1989-03-07 | Mitsui Sugar Co | Sport drink for supplying energy |
US6248378B1 (en) * | 1998-12-16 | 2001-06-19 | Universidad De Sevilla | Enhanced food products |
JP2001187736A (en) * | 1999-10-20 | 2001-07-10 | Ito En Ltd | Nutritive analeptic and nutritive analeptic drink |
US6444241B1 (en) * | 2000-08-30 | 2002-09-03 | Wm. Wrigley Jr. Company | Caffeine coated chewing gum product and process of making |
US20030219500A1 (en) * | 1996-05-31 | 2003-11-27 | Howard Alan N. | Compositions containing creatine and creatinine and a methyl xanthine |
US20040058033A1 (en) * | 2002-04-05 | 2004-03-25 | Giuseppe Sozzi | Chewing gum in powder form and a method of preparation |
WO2005061690A1 (en) * | 2003-12-19 | 2005-07-07 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Low-alcohol beer or beer-like refreshment beverages containing palatinose |
US20060051456A1 (en) * | 2004-08-25 | 2006-03-09 | Cadbury Schweppes | Liquid-filled chewing gum composition |
US20060292134A1 (en) * | 2005-06-22 | 2006-12-28 | Sidney Stohs | Composition for enhancing cellular energy |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8907007D0 (en) * | 1989-03-28 | 1989-05-10 | Tate & Lyle Plc | Sucralose compositions |
JPH0797964B2 (en) | 1987-11-07 | 1995-10-25 | 株式会社ロッテ | Sweetened condensed milk-like composition and method for producing the same |
US5659028A (en) * | 1990-02-23 | 1997-08-19 | Raffinerie Tirlemontoise S.A. | Branched fructo-oligosaccharides, method for obtaining them and use of products containing them |
JP2922984B2 (en) | 1990-06-01 | 1999-07-26 | 株式会社ロッテ | Flavoring composition for chewing gum |
US5378131A (en) * | 1993-02-18 | 1995-01-03 | The Wm. Wrigley Jr. Company | Chewing gum with dental health benefits employing calcium glycerophosphate |
US5614224A (en) * | 1995-04-20 | 1997-03-25 | Womack; Rick W. | Nutritional supplement for diabetics |
GB9611356D0 (en) * | 1996-05-31 | 1996-08-07 | Howard Alan N | Improvements in or relating to compositions containing Creatine, and other ergogenic compounds |
FR2753098B1 (en) | 1996-09-06 | 1998-11-27 | Sod Conseils Rech Applic | PHARMACEUTICAL COMPOSITION COMPRISING AT LEAST ONE NO SYNTHASE INHIBITOR AND AT LEAST ONE TRAP FOR REACTIVE OXYGEN FORMS |
US6713116B1 (en) * | 1998-03-26 | 2004-03-30 | Nutrinova Inc. | Sweet-stable acidified beverages |
JP4273277B2 (en) * | 1999-06-30 | 2009-06-03 | 大塚製薬株式会社 | Oligosaccharide supplement composition |
AU7322100A (en) * | 1999-10-04 | 2001-05-10 | Ajinomoto Co., Inc. | Sweetener compositions with high degree of sweetness having improved sweetness, corrigents and utilization thereof |
JP2001169752A (en) * | 1999-12-15 | 2001-06-26 | Fancl Corp | Food composition |
US20020193342A1 (en) * | 2001-05-09 | 2002-12-19 | Hamman John P. | Modifying undesirable tastes |
MY135783A (en) * | 2001-09-07 | 2008-06-30 | Meiji Dairies Corp | Nutritional composition for controlling blood sugar level |
US20030143311A1 (en) * | 2001-10-26 | 2003-07-31 | William Gillota | Recovery drink formula and method |
US20040241256A1 (en) * | 2002-12-05 | 2004-12-02 | Seymour Ehrenpreis | Medicinal compositions & therapeutic methods |
AU2003245156A1 (en) | 2002-06-21 | 2004-01-06 | Canacure Corporation | Liquid compositions comprising non-digestible oligosaccharides and green tea catechins, method and uses thereof |
EP1410721B2 (en) | 2002-10-17 | 2012-08-08 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Process for manufacturing an isomaltulose-containing enteral food |
GB0306394D0 (en) * | 2003-03-20 | 2003-04-23 | Univ Nottingham | Carnitine retention |
KR20040092232A (en) | 2003-04-25 | 2004-11-03 | 주식회사 케이티앤지 | Composition of Korean Red Ginseng for Improving Sexual Function, Manufacturing Method the Same and Its Use |
US20060188627A1 (en) | 2003-07-23 | 2006-08-24 | Brouns Fredericus Johannes P H | Isomaltulose or trehalose containing comestibles for sustained carbohydrate energy release and increased fat oxidation |
JP4847862B2 (en) | 2004-04-14 | 2011-12-28 | 協和発酵バイオ株式会社 | Tablet containing branched-chain amino acid and method for producing the same |
US8283327B2 (en) | 2005-03-19 | 2012-10-09 | Kneller Bruce W | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
ES2419205T3 (en) | 2005-04-06 | 2013-08-19 | Nestec S.A. | Composition to improve glycemic regulation and insulin action, nutritiously |
US10626915B2 (en) | 2017-07-13 | 2020-04-21 | Federal-Mogul Motorparts Llc | Vertical control arm bushing with dust boot having strengthening portions |
-
2006
- 2006-03-20 US US11/385,137 patent/US8283327B2/en active Active
-
2009
- 2009-03-25 US US12/410,861 patent/US20090181922A1/en not_active Abandoned
- 2009-07-16 US US12/504,480 patent/US20090281055A1/en not_active Abandoned
-
2012
- 2012-01-17 US US13/351,747 patent/US20120183671A1/en not_active Abandoned
- 2012-12-10 US US13/709,763 patent/US20130095125A1/en not_active Abandoned
-
2017
- 2017-08-01 US US15/666,528 patent/US10624915B2/en active Active
-
2020
- 2020-02-07 US US16/785,498 patent/US11103522B2/en active Active
- 2020-02-13 US US16/790,667 patent/US20200237792A1/en not_active Abandoned
- 2020-03-19 US US16/824,140 patent/US20200215088A1/en not_active Abandoned
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6460360A (en) * | 1987-08-31 | 1989-03-07 | Mitsui Sugar Co | Sport drink for supplying energy |
US20030219500A1 (en) * | 1996-05-31 | 2003-11-27 | Howard Alan N. | Compositions containing creatine and creatinine and a methyl xanthine |
US6248378B1 (en) * | 1998-12-16 | 2001-06-19 | Universidad De Sevilla | Enhanced food products |
JP2001187736A (en) * | 1999-10-20 | 2001-07-10 | Ito En Ltd | Nutritive analeptic and nutritive analeptic drink |
US6444241B1 (en) * | 2000-08-30 | 2002-09-03 | Wm. Wrigley Jr. Company | Caffeine coated chewing gum product and process of making |
US20040058033A1 (en) * | 2002-04-05 | 2004-03-25 | Giuseppe Sozzi | Chewing gum in powder form and a method of preparation |
WO2005061690A1 (en) * | 2003-12-19 | 2005-07-07 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Low-alcohol beer or beer-like refreshment beverages containing palatinose |
US20070116801A1 (en) * | 2003-12-19 | 2007-05-24 | Kowalczyk Joerg | Low-alcohol beer or beer-like refreshment beverages containing palatinose |
US20060051456A1 (en) * | 2004-08-25 | 2006-03-09 | Cadbury Schweppes | Liquid-filled chewing gum composition |
US20060292134A1 (en) * | 2005-06-22 | 2006-12-28 | Sidney Stohs | Composition for enhancing cellular energy |
Non-Patent Citations (1)
Title |
---|
Suzuki et al., J. Clin. Biochem. Nutr., 1992, 13, p117-125. * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10624915B2 (en) | 2005-03-19 | 2020-04-21 | Bruce W. Kneller | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
US11103522B2 (en) | 2005-03-19 | 2021-08-31 | Bruce W. Kneller | Palatinose for enhancing dietary supplement and pharmaceutical delivery |
Also Published As
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US20200215088A1 (en) | 2020-07-09 |
US20200237792A1 (en) | 2020-07-30 |
US20090181922A1 (en) | 2009-07-16 |
US20060153899A1 (en) | 2006-07-13 |
US20130095125A1 (en) | 2013-04-18 |
US11103522B2 (en) | 2021-08-31 |
US20200237791A1 (en) | 2020-07-30 |
US20170340657A1 (en) | 2017-11-30 |
US20090281055A1 (en) | 2009-11-12 |
US10624915B2 (en) | 2020-04-21 |
US8283327B2 (en) | 2012-10-09 |
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