US20130072904A1 - Micromachined medical devices - Google Patents
Micromachined medical devices Download PDFInfo
- Publication number
- US20130072904A1 US20130072904A1 US13/658,309 US201213658309A US2013072904A1 US 20130072904 A1 US20130072904 A1 US 20130072904A1 US 201213658309 A US201213658309 A US 201213658309A US 2013072904 A1 US2013072904 A1 US 2013072904A1
- Authority
- US
- United States
- Prior art keywords
- slots
- medical device
- micromachined hypotube
- outer shaft
- micromachined
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0054—Catheters; Hollow probes characterised by structural features with regions for increasing flexibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M25/0029—Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M25/0032—Multi-lumen catheters with stationary elements characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M25/0138—Tip steering devices having flexible regions as a result of weakened outer material, e.g. slots, slits, cuts, joints or coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
Definitions
- the invention relates generally to medical devices and more specifically to medical devices that include micromachined components.
- Such medical devices may include, for example, catheters.
- Medical devices such as catheters may be subject to a number of often conflicting performance requirements such as flexibility, strength, minimized exterior diameter, maximized interior diameter, and the like.
- flexibility such as flexibility, strength, minimized exterior diameter, maximized interior diameter, and the like.
- a need remains for improved medical devices such as catheters that are configured for an optimal balance between flexibility, strength, and other desired properties.
- the invention pertains to improved medical devices providing advantages in flexibility, strength and other desired properties.
- an example embodiment of the invention can be found in a catheter that includes an elongate tube extending from a distal region of the catheter to a proximal region of the catheter.
- a number of slots extending radially about the elongate tube are disposed along the elongate tube.
- a polymeric dual-lumen liner is disposed within the elongate tube.
- a catheter that includes an elongate metal tube extending from a distal region of the catheter to a proximal region of the catheter.
- a number of flexibility-induced slots extending radially about the elongate metal tube are disposed along the elongate metal tube.
- a polymeric sleeve is disposed about the elongate metal tube while a polymeric dual-lumen liner is disposed within the elongate metal tube.
- a catheter having a distal region defining a distal end and a proximal region defining a proximal end.
- the catheter includes a polymer sheath that extends from the distal end of the catheter to the proximal end of the catheter.
- a micromachined hypotube is disposed over the polymer sheath and includes a distal region defining a distal end and a proximal region defining a proximal end.
- the micromachined hypotube extends from the distal region of the catheter to the proximal region of the catheter such that the polymer sheath extends distally from the distal end of the micromachined hypotube.
- the micromachined hypotube includes a number of radially-extending, flexibility-inducing slots disposed along the micromachined hypotube.
- Another example embodiment of the invention can be found in a catheter that includes an elongate shaft and at least one micromachined marker band that is disposed within a distal region of the catheter.
- a catheter that includes an elongate polymer sheath, the polymer sheath defining a lumen extending through the polymer sheath.
- a balloon is secured to the elongate polymer sheath within a distal region of the elongate polymer sheath.
- At least one micromachined compression ring is disposed proximal of the balloon within the elongate polymer sheath lumen.
- a catheter that includes an inner shaft defining a guidewire lumen and an inflation lumen and an outer shaft disposed over the inner shaft such that the outer shaft extends distally beyond a distal end of the inner shaft.
- a balloon defining a balloon interior is disposed on the outer shaft within a distal region of the catheter.
- a micromachined hypotube is disposed within the guidewire lumen and extends distally through the balloon interior. The micromachined hypotube includes one or more cutouts to accommodate one or more marker bands disposed on the micromachined hypotube.
- a balloon catheter that includes an elongate shaft and a balloon disposed on the elongate shaft.
- the balloon includes a proximal waist bonded to the elongate shaft and a distal waist bonded to the elongate shaft.
- the distal waist and the proximal waist each include a number of radially disposed cuts intended to improve flexibility.
- a medical device that includes an outer shaft and an inner shaft disposed within the outer shaft such that the inner shaft extends beyond an outer shaft end of the outer shaft.
- a collapsible cage is disposed over the inner shaft.
- the collapsible shaft includes a first end that is attached to the outer shaft end and a second end that is attached to an attachment point on the inner shaft.
- the collapsible cage is moveable between a moveable position in which the outer shaft may move with respect to the inner shaft and a locked position in which the outer shaft is locked to the inner shaft and cannot move.
- a medical device that includes an outer shaft and an inner shaft disposed within the outer shaft such that the inner shaft extends beyond an outer shaft end of the outer shaft.
- a polymer sleeve is disposed over the inner shaft.
- the polymer sleeve includes a first end that is attached to the outer shaft end and a second end that is attached to an attachment point on the inner shaft.
- the polymer sleeve is moveable between a rotation position in which the outer shaft may rotate with respect to the inner shaft and a locked position in which the outer shaft is locked to the inner shaft and cannot rotate.
- a medical device that includes a micromachined hypotube having a number of radially-extending, flexibility-inducing slots disposed along the micromachined hypotube.
- a polymer insert is disposed within a lumen defined by the micromachined hypotube.
- the polymer insert has a non-round radial cross-section and includes at least one lumen disposed within the polymer insert.
- a catheter that includes an elongate hypotube having a hypotube lumen.
- the elongate hypotube extends from a distal region of the catheter to a proximal region of the catheter and includes a number of slots disposed within the elongate hypotube.
- An inflatable balloon is disposed about a distal region of the elongate hypotube.
- An outer sheath is disposed proximal to the inflatable balloon covering at least the distal region of the elongate hypotube such that the outer sheath seals the plurality of slots so that the hypotube lumen may be used for inflating and deflating the inflatable balloon.
- a micromachined hypotube that includes a first number of slots that are disposed within a first portion of the micromachined hypotube and a second number of slots that are disposed within a second portion of the micromachined hypotube.
- the slots extend at least partially circumferentially around the micromachined hypotube.
- the second number of slots include adjacent slots having a spacing therebetween that is less than a spacing between adjacent slots within the first plurality of slots.
- Another example embodiment of the invention can be found in a micromachined hypotube having a number of slots disposed within the micromachined hypotube.
- the slots extend from the outer surface to the inner surface and each of the number of slots include a first portion extending at an acute angle with respect to the axial axis and a second portion arranged at least substantially perpendicular to the first portion.
- Another example embodiment of the invention can be found in a micromachined hypotube that has an inner surface, an outer surface and a number of radially-extending slots disposed on the micromachined hypotube, each of the radially-extending slots having a first diameter at the inner surface and a second diameter at the outer surface, the second diameter being greater than the first diameter.
- Another example embodiment of the invention can be found in a micromachined hypotube that has an axial axis.
- a number of slots are disposed at least substantially perpendicular to the axial axis. At least some of the slots have a first edge and a second edge, the first edge of at least some of the slots including a button that extends toward the second edge of at least some of the slots.
- FIG. 1 is a view of a micromachined hypotube in accordance with an embodiment of the invention
- FIG. 2 is a view of a micromachined hypotube in accordance with an embodiment of the invention.
- FIG. 3 is a view of a micromachined hypotube in accordance with an embodiment of the invention.
- FIG. 4 is a view of a micromachined hypotube in accordance with an embodiment of the invention.
- FIG. 5 is a view of a micromachined hypotube in accordance with an embodiment of the invention.
- FIG. 6 is a view of a catheter in accordance with an embodiment of the invention.
- FIG. 7 is a partial longitudinal cross-sectional view of a proximal portion of the catheter of FIG. 6 ;
- FIG. 8 is a partial longitudinal cross-sectional view of an intermediate portion of the catheter of FIG. 6 ;
- FIG. 9 is a partial longitudinal cross-sectional view of a distal portion of the catheter of FIG. 6 ;
- FIG. 10 is a cross-sectional view taken along line 10 - 10 of FIG. 6 ;
- FIG. 11 is a cross-sectional view taken along line 11 - 11 of FIG. 6 ;
- FIG. 12 is a view of a catheter in accordance with an embodiment of the invention.
- FIG. 13 is a cross-sectional view taken along line 13 - 13 of FIG. 12 ;
- FIG. 14 is a cross-sectional view taken along line 14 - 14 of FIG. 12 ;
- FIG. 15 is a partial longitudinal view of structure present within the catheter of FIG. 12 ;
- FIG. 16 is a view of a catheter in accordance with an embodiment of the invention.
- FIG. 17 is a cross-sectional view taken along line 17 - 17 of FIG. 16 ;
- FIG. 18 is a cross-sectional view taken along line 18 - 18 of FIG. 16 ;
- FIG. 19 is a view of a portion of a catheter in accordance with an embodiment of the invention.
- FIG. 20 is a view of a portion of a catheter in accordance with an embodiment of the invention.
- FIG. 21 is a view of a portion of a catheter in accordance with an embodiment of the invention.
- FIG. 22 is a view of a balloon bonded to a catheter shaft in accordance with an embodiment of the invention.
- FIG. 23 is a view of the balloon of FIG. 22 , illustrating post-attachment processing in accordance with an embodiment of the invention
- FIG. 24 is a view of an assembly including outer shaft attached to an inner shaft via a collapsible cage in accordance with an embodiment of the invention
- FIG. 25 is a view of the assembly of FIG. 24 , shown with the cage in a collapsed configuration in accordance with an embodiment of the invention
- FIG. 26 is a view of an assembly including an outer shaft attached to an inner shaft via a collapsible electroactive polymer sleeve in accordance with an embodiment of the invention
- FIG. 27 is a view of the assembly of FIG. 26 , shown with the electroactive polymer sleeve in a collapsed configuration in accordance with an embodiment of the invention
- FIG. 28 is a view of an assembly in accordance with an embodiment of the invention.
- FIG. 29 is a view of an assembly in accordance with an embodiment of the invention.
- FIG. 30 is a view of an assembly in accordance with an embodiment of the invention.
- FIG. 31 is a view of a portion of a catheter in accordance with an embodiment of the invention.
- FIG. 32 is a view of a portion of a catheter in accordance with an embodiment of the invention.
- the invention pertains generally to medical devices that include micromachined hypotubes or other elements that have been micromachined.
- a variety of micromachined hypotubes are within the scope of the invention and are useful in the medical devices described herein.
- FIGS. 1-5 illustrate particular, but non-limiting, micromachined hypotubes as contemplated within the boundaries of the invention.
- FIG. 1 illustrates a micromachined hypotube 10 having a proximal region 12 defining a proximal end 14 and a distal region 16 defining a distal end 18 .
- the micromachined hypotube 10 can be seen as having an axial axis 20 extending the length of the hypotube 10 .
- One or more slots 22 are disposed along the length of the micromachined hypotube 10 .
- the slots 22 are arranged at least substantially perpendicular to the axial axis 20 .
- the slots 22 may be arranged at an angle with respect to the axial axis 20 , or may even be parallel to the axial axis 20 .
- Each of the slots 22 extend only partially around the circumference of the micromachined hypotube 10 .
- an individual slot 22 may extend about half way around the circumference of the micromachined hypotube.
- an individual slot 22 can extend more than halfway around, if for example, increased flexibility is of highest importance.
- each individual slot 22 may extend less than halfway around the micromachined hypotube 10 .
- an individual slot 22 extends only a relatively short circumferential difference about the micromachined hypotube 10 , it is contemplated that two, three or more slots 22 may be disposed radially about a single axial position along the micromachined hypotube 10 . In some instances, an individual slot 22 may extend completely through the micromachined hypotube. In some cases, one or more of the individual slots 22 may have a depth less than a wall thickness of the micromachined hypotube 10 .
- individual slots 22 may be considered as being in pairs 24 , with a pair 24 including a first slot 26 and a second slot 28 .
- the first slot 26 can have a first radial position on the micromachined hypotube 10 while the second slot 28 occupies a second radial position that is rotated from the first radial position.
- the second slot 28 can be rotated about 90 degrees from the first slot 26 .
- the radial rotation can vary, especially if, for example, first slot 26 and first slot 28 are either longer or shorter than the illustrated length.
- an individual slot 22 may be rectangular in shape. In some instances, an individual slot 22 may be curved, such as a semi-circular shape. In some cases, an individual slot 22 may be diamond-shaped. An individual slot 22 may be formed using any suitable technique, such as saw cutting, a laser, or even by electrical discharge machining (EDM). Additional suitable techniques include chemical etching and abrasive grinding.
- EDM electrical discharge machining
- the micromachined hypotube 10 may be formed of any suitable polymeric or metallic material.
- the micromachined hypotube 10 may be formed of a suitably stiff polymer such as carbon fibers, liquid crystal polymers, polyimide, and the like.
- the micromachined hypotube 10 may be formed of a metallic material such as stainless steel or a nickel-titanium alloy such as Nitinol or other metallic or polymeric shape-memory material.
- the micromachined hypotube 10 may include a combination of metal tubes and polymer tubes, if desired.
- micromachined hypotube 10 may be formed having any desired length, width, material thickness, and slot size as required to satisfy the requirements of any particular application. Additional details concerning micromachined hypotube 10 , including the manufacture thereof, can be found, for example, in U.S. Pat. No. 6,766,720 and published U.S. Patent Application No. 2004/0181174A2, each of which are fully incorporated, in their entirety, by reference herein.
- each of the slots 22 disposed within micromachined hypotube 10 are evenly axially spaced.
- FIG. 2 illustrates an embodiment in which the inter-slot spacing is varied.
- FIG. 2 shows a micromachined hypotube 30 having a proximal region 32 defining a proximal end 34 and a distal region 36 defining a distal end 38 .
- the micromachined hypotube 30 has an axial axis 40 extending the length of the hypotube 30 .
- a number of slots 42 are disposed along the length of the micromachined hypotube 10 .
- the slots 42 are arranged at least substantially perpendicular to the axial axis 40 . In other instances, the slots 42 may be arranged at an angle with respect to the axial axis 40 .
- Each of the slots 42 extend only partially around the circumference of the micromachined hypotube 30 .
- an individual slot 42 may extend about half way around the circumference of the micromachined hypotube.
- an individual slot 42 can either extend less than halfway around, or conversely, more than halfway around, depending on the relative importance of flexibility and strength.
- individual slots 42 can be radially offset from adjacent slots 42 .
- FIG. 2 illustrates variety in inter-slot spacing.
- individual slots 42 may be considered as being in pairs 44 , with a pair 44 including a first slot 46 and a second slot 48 .
- individual slots may be considered as being in pairs 50 , with a pair 50 including a first slot 52 and a second slot 54 .
- the axial spacing between first slot 46 and second slot 48 of pair 44 is greater than the axial spacing between first slot 52 and second slot 54 of pair 50 . This can be done to provide relatively greater flexibility within the distal region 36 .
- the inter-slot spacing within the proximal region 32 may be a first constant while the inter-slot spacing within the distal region 36 may be a second, smaller constant. In some cases, the inter-slot spacing may change on a step-wise fashion moving from the proximal region 32 to the distal region 36 . In some instances, the inter-slot spacing may change in a more continuous manner when moving from the proximal region 32 to the distal region 36 .
- FIG. 3 illustrates another exemplary slot pattern.
- FIG. 3 shows a micromachined hypotube 56 having a proximal region 58 and a distal region 60 .
- An axial axis 62 extends through the micromachined hypotube 56 .
- the micromachined hypotube 56 includes a number of slots 64 .
- Each slot 64 can be seen to include a first portion 66 , a second portion 68 and an intervening apex 70 .
- the apex 70 of several axially aligned slots 64 may be seen to lie along a line 72 that is parallel with the axial axis 62 .
- first portion 66 forms an acute angle with the line 72
- second portion 68 is at least substantially perpendicular to the first portion 66
- first portion 66 and the second portion 68 may form similar angles with the line 72 yet form an angle of less than about 90 degrees between the first portion 66 and the second portion 68 .
- first portion 66 and the second portion 68 may form an angle between themselves that is greater than about 90 degrees.
- adjacent slots 64 may be radially offset.
- FIG. 4 illustrates a micromachined hypotube 74 that has a distal region 76 defining a distal end 78 and a proximal region 80 defining a proximal end 82 .
- the micromachined hypotube defines an axial axis 84 extending therethrough.
- the micromachined hypotube 74 has an inner surface 86 and an outer surface 88 .
- a number of tapered slots 90 are disposed within the micromachined hypotube 74 and are at least substantially radially aligned, i.e. are at least substantially perpendicular to the axial axis 84 . As discussed previously with respect to FIGS. 1 and 2 , adjacent tapered slots 90 may be radially offset.
- the tapered slots 90 can be seen to have opposing lower edges 92 at inner surface 86 and opposing upper edges 94 at outer surface 88 .
- the tapered slots 90 are constructed such that each tapered slot 90 has a major dimension that is at least substantially perpendicular to the axial axis 84 and a minor dimension that is orthogonal to the major dimension.
- the major dimension may be considered to be a length of the tapered slot 90
- the minor dimension may be considered to be a width of the tapered slot.
- each tapered slot 90 has a minor dimension, or width between opposing upper edges 94 , at the outer surface 88 that is larger than the minor dimension, or width between opposing lower edges 92 , of the same tapered slot 90 at the inner surface 86 .
- the width of the tapered slot 90 at the outer surface 88 can be about twice the corresponding inner surface 86 width.
- tapered slots 90 having a relatively wider opening at the outer surface 88 , relatively greater flexibility can be obtained in micromachined hypotube 74 as the micromachined hypotube 74 can bend further before opposing upper edges 94 come into contact with each other.
- relatively greater column strength may be obtained in micromachined hypotube 74 as the bottom edges of the tapered slot 90 will contact each other as compressive force is applied to the micromachined hypotube 74 .
- each tapered slot 90 may be similarly tapered. In other cases, the slot ends may not be tapered.
- Each of the tapered slots 90 extend only partially around the circumference of the micromachined hypotube 74 . In some instances, an individual tapered slot 90 may extend about half way around the circumference of the micromachined hypotube 74 . In other cases, an individual tapered slot 90 can either extend less than halfway around, or conversely, more than halfway around, depending on the relative importance of flexibility and strength. As discussed with respect to FIG. 1 , individual tapered slots 90 can be radially offset from adjacent tapered slots 90 .
- FIG. 5 shows a micromachined hypotube 96 having a proximal region 98 defining a proximal end 100 and a distal region 102 defining a distal region 104 .
- An axial axis 106 extends through the micromachined hypotube 96 .
- a number of slots 108 are disposed within the micromachined hypotube 96 and are at least substantially radially aligned, i.e. are at least substantially perpendicular to the axial axis 106 . As discussed previously with respect to FIGS. 1 and 2 , adjacent slots 108 may be radially offset.
- Each of the slots 108 can be seen as including a proximal edge 110 and a distal edge 112 .
- Some of the slots 108 may include a protrusion or button 114 on at least one of the proximal edge 110 and the distal edge 112 .
- These buttons 114 may be integrally formed with micromachined hypotube 96 .
- the buttons 114 can be added subsequently to forming the micromachined hypotube 96 .
- buttons 114 could include or be formed from small amounts of molten material such as solder, or perhaps the stainless steel or even nitinol from which the micromachined hypotube 96 was formed.
- the buttons 114 may be formed via electrical discharge machining (EDM).
- buttons 114 may be provided or formed along proximal edge 110 of the slots 108 . In other cases, buttons 114 could be included along the distal edge 112 of the slots 108 . It is contemplated that buttons 114 could be provided along the proximal edge 110 of some of the slots 108 and along the distal edge 112 of some of the other slots 108 . The number and placement of the buttons 114 can be varied to achieve a desired level of column support.
- FIGS. 6 through 11 illustrate an example use of the micromachined hypotubes 10 , 30 , 56 , 74 and 96 discussed herein.
- FIG. 6 shows a catheter 116 having a proximal region 118 defining a proximal end 120 and a distal region 122 defining a distal end 124 .
- Catheter 116 can be one of a variety of different catheters, but is preferably an intravascular catheter. Examples of intravascular catheters include balloon catheters, atherectomy catheters, stent delivery catheters such as those adapted to deploy self-expanding stents, filter delivery catheters, diagnostic catheters and guide catheters. As illustrated, FIG. 6 portrays a balloon catheter, but the invention is not limited to such.
- a hub 126 is secured to the catheter 116 near the proximal end 120 .
- a balloon 128 is secured to the catheter 116 within the distal region 124 .
- the hub 126 and the balloon 128 can be of any known construction.
- a guidewire port 130 is disposed within the catheter 116 at a position proximal of the balloon 128 but well distal of the hub 126 .
- the guidewire port 130 can be positioned relatively close to the distal end 124 of the catheter 116 to provide catheter 116 with rapid exchange capabilities, even if a guidewire lumen (not illustrated in this view) extends throughout the length of the catheter 116 .
- the catheter 116 includes an elongate shaft 132 extending from the hub 126 to at least the distal region 122 , if not the distal end 124 , of the catheter 116 .
- the elongate shaft 132 may be of any suitable material.
- the elongate shaft 132 may be a micromachined hypotube such as those described with respect to FIGS. 1-5 .
- the slots are not shown in FIG. 6 , simply for clarity.
- the catheter 116 may include one more polymeric elements within an interior of the elongate shaft 132 .
- FIG. 7 is a partial cross-sectional view of a portion of the proximal region 118 , including a portion of hub 126 .
- a micromachined hypotube 134 can be seen as extending distally out of the hub 126 . Similar to several of the micromachined hypotubes discussed previously, micromachined hypotube 134 includes a number of radially-oriented slots 135 . While slots 135 are shown as being similar to those shown in FIG. 1 , it should be recognized that a number of other arrangements are contemplated.
- the micromachined hypotube 134 also includes several apertures 136 .
- One or more apertures 136 may be spaced about the circumference of the micromachined hypotube 134 .
- a total of four apertures 136 may be equally spaced about the circumference of the micromachined hypotube 134 .
- either fewer than four or perhaps even more than four apertures 136 may be included. While the illustrated apertures 136 are round, other shapes are contemplated.
- the apertures 136 are included within the micromachined hypotube 134 in order to provide for additional attachment points between the micromachined hypotube 134 and the polymeric liner (which will be discussed in greater detail hereinafter) positioned within the micromachined hypotube 134 . In some instances, additional polymeric material may be melted into the apertures 136 to secure the polymeric liner to the micromachined hypotube 134 .
- FIG. 8 shows another section of the micromachined hypotube 134 , corresponding to either side of the guidewire port 130 ( FIG. 7 ).
- This portion of the micromachined hypotube 134 includes a guidewire aperture 138 that is configured and positioned to align with the guidewire port 130 and thus permit access to the interior of the micromachined hypotube 134 .
- the guidewire aperture 138 may be somewhat generalized in FIG. 8 , and may have a curved or semicircular shape, depending on how it is formed.
- One or more apertures 140 can be positioned just proximal of the guidewire aperture 138 and one or more apertures 142 can be positioned just distal of the guidewire aperture 138 .
- the apertures 140 and 142 may be spaced about the circumference of the micromachined hypotube 134 . In some embodiments, a total of four apertures 140 and a total of four apertures 142 may be equally spaced about the circumference of the micromachined hypotube 134 . In other instances, either fewer than four or perhaps even more than four of apertures 140 and 142 may be included. While the illustrated apertures 140 and 142 are round, other shapes are contemplated.
- the apertures 140 and 142 are included within the micromachined hypotube 134 in order to provide for additional attachment points between the micromachined hypotube 134 and the polymeric liner positioned therein. In some instances, additional polymeric material may be melted into the apertures 140 and 142 to secure the polymeric liner to the micromachined hypotube 134 .
- FIG. 9 is a partial cross-section view of a portion of the distal region 122 , showing the micromachined hypotube 134 as well as a portion of the balloon 128 .
- One or more apertures 144 can be positioned just proximal of a proximal end 146 of the balloon 128 .
- the apertures 144 may be spaced about the circumference of the micromachined hypotube 134 .
- a total of four apertures 144 may be equally spaced about the circumference of the micromachined hypotube 134 . In other instances, either fewer than four or perhaps even more than four of apertures 144 may be included. While the illustrated apertures 144 are round, other shapes are contemplated.
- the apertures 144 are included within the micromachined hypotube 134 in order to provide for additional attachment points between the micromachined hypotube 134 and the polymeric liner positioned therein. In some instances, additional polymeric material may be melted into the apertures 144 to secure the polymeric liner to the micromachined hypotube 134 .
- FIG. 10 is a cross-section of FIG. 6 , taken along line 10 - 10 , illustrating the construction of the elongate shaft 132 ( FIG. 6 ).
- a polymeric liner 148 can be seen positioned within micromachined hypotube 134 .
- the polymeric liner 148 includes a guidewire lumen 150 and an inflation lumen 152 .
- the polymeric liner 148 could include either a greater or lesser number of lumens, as dictated by the intended use of catheter 116 ( FIG. 6 ).
- the polymeric liner 148 can be made of any suitable polymeric material.
- suitable materials include polyethylene, polyurethane, elastomeric polyamides, block polyamide/ethers (such as PEBAX®), silicones, co-polymers, thermoplastic polymers such as a co-polyester thermoplastic elastomer such as that available commercially under the ARNITEL® name, and fluoropolymers such as PTFE.
- the polymeric liner 148 may be formed of high density polyethylene. If the polymeric liner 148 is formed of high density polyethylene, the same material may be used to melt into apertures 136 ( FIG. 7 ), apertures 140 and 142 ( FIG. 8 ) and apertures 144 ( FIG. 9 ), in order to secure polymeric liner 148 to micromachined hypotube 134 .
- FIG. 11 is a cross-section of FIG. 6 , taken along line 11 - 11 , illustrating additional construction details of the elongate shaft 132 ( FIG. 6 ) as pertaining to the guidewire port ( 136 ).
- the micromachined hypotube 134 and the polymeric liner 148 have been milled, ground, or otherwise processed or provide an opening 154 that permits access to the guidewire lumen 150 from a position exterior to the catheter 116 .
- FIGS. 12-15 illustrate another example use of the micromachined hypotubes 10 , 30 , 56 , 74 and 96 discussed herein.
- FIG. 12 shows a catheter 156 having a proximal region 158 defining a proximal end 160 and a distal region 162 defining a distal end 164 .
- Catheter 156 can be one of a variety of different catheters, but is preferably an intravascular catheter. Examples of intravascular catheters include balloon catheters, atherectomy catheters, stent delivery catheters, filter delivery catheters, diagnostic catheters and guide catheters.
- Catheter 156 can include one or more constructional elements, as will be discussed. As illustrated, the catheter 156 includes a guidewire lumen 168 and an inflation lumen 170 , although in some instances catheter 156 can include additional lumens. In some cases, catheter 156 may only include a single lumen that can be used both as a guidewire lumen and as an inflation lumen, should catheter 156 be a balloon catheter. For clarity, a balloon is not illustrated in FIG. 12 . The catheter 156 also includes a guidewire port 166 that provides access to the interior of the guidewire lumen 168 .
- FIGS. 13 and 14 are cross-sections taken through FIG. 12 .
- FIG. 13 is taken through the proximal region 158 of FIG. 12 while FIG. 14 is taken through the distal region 162 of FIG. 12 .
- the catheter 156 can be seen to include an inner polymeric liner 172 that defines guidewire lumen 168 and inflation lumen 170 , an outer polymeric sheath 176 and an intervening micromachined hypotube 174 .
- the micromachined hypotube 174 can include any construction discussed herein with respect to position, configuration and frequency of slots.
- FIG. 14 which is a cross-section taken distally of the guidewire port 166 ( FIG. 12 ), it can be seen that only a portion of the micromachined hypotube 174 remains. In particular, the upper portion, which would otherwise interfere with a guidewire (not illustrated) gaining access to the guidewire lumen 168 , has been removed.
- FIG. 15 is a side view of the micromachined hypotube 174 , which has a proximal end 178 , a distal region 180 and a distal end 182 . It can be seen that much of the material has been removed in the distal region 180 , forming profile 184 . In some instances, the material can be removed from the distal region 180 using any suitable technique such as grinding, cutting, laser and the like. In some cases, it is contemplated that profile 184 can instead be formed by crushing the distal region 180 of the micromachined hypotube 174 , rather than material removal.
- FIG. 16-18 illustrate another example use of the micromachined hypotubes discussed herein.
- FIG. 16 shows a catheter 186 having a proximal region 188 defining a proximal end 190 and a distal region 192 defining a distal end 194 .
- catheter 186 is an over-the-wire, or single-operator-exchange (SOE) catheter, but is not limited to such.
- the catheter 186 includes a polymeric sheath 196 that extends from the proximal end 190 to the distal end 194 .
- Micromachined hypotube 32 FIG. 2
- is seen deployed over polymeric sheath 196 as also illustrated in FIGS. 17 and 18 .
- the polymeric sheath 196 may be formed of any suitable polymeric material.
- suitable materials include polyethylene, polyurethane including high density polyurethane, elastomeric polyamides, block polyamide/ethers (such as PEBAX®), silicones, co-polymers, thermoplastic polymers such as a co-polyester thermoplastic elastomer such as that available commercially under the ARNITEL® name, and fluoropolymers such as PTFE.
- the polymeric sheath 196 may be formed of particular materials and to particular dimensions such that the polymeric sheath 196 is highly flexible but lacks sufficient column strength for pushing the catheter 186 through a body lumen.
- the micromachined hypotube 32 provides a desired level of column strength without excessively impacting flexibility.
- the distal end 38 of the micromachined hypotube 32 may be positioned proximal of the distal end 194 of the catheter 186 in order to not impact the flexibility of the distal end 194 . In some cases, the distal end 38 of the micromachined 32 may be positioned at least about 4 centimeters from the distal end 194 and no more than about 20 centimeters from the distal end 194 . If the distal end 38 of the micromachined hypotube 32 is too far from the distal end 194 of the catheter 186 , pushability may suffer. Conversely, if the distal end 38 is too close to distal end 194 , flexibility can suffer.
- the proximal end 34 of the micromachined hypotube 32 ends at a position that is distal to the proximal end 190 of the catheter 186 .
- the micromachined hypotube 32 may extend further proximally such that the proximal end 34 is adjacent to or even proximal of the proximal end 190 of the catheter 186 . It is contemplated that extending the micromachined hypotube 32 proximally of the proximal end 190 of the catheter 186 may provide handling advantages.
- FIG. 19 illustrates a particular application of a micromachined hypotube as contemplated herein.
- a distal portion 200 of a catheter 198 is shown.
- the catheter 198 may be any particular intravascular catheter and can include one or more marker bands 202 .
- Marker bands 202 are unique in that they are sections of micromachined hypotubes such as those discussed with respect to FIGS. 1 through 5 . By using micromachined hypotubes as marker bands 202 , additional flexibility may be achieved.
- Marker bands 202 may be formed of any suitably radiopaque material, such as gold, platinum, palladium, tantalum, tungsten alloy, and the like.
- FIG. 20 illustrates another particular application of a micromachined hypotube such as those discussed with respect to FIGS. 1 through 5 .
- FIG. 20 is a partial longitudinal cross-section of a distal portion 206 of a balloon catheter 204 having a distal end 208 .
- the balloon catheter 204 includes an elongate shaft 210 and a balloon 212 disposed on the elongate shaft.
- One or more compression rings 214 are positioned within the elongate shaft 210 , proximal of the balloon 212 .
- the compression rings 214 are unique in that they are sections of micromachined hypotubes such as those discussed with respect to FIGS. 1 through 5 . By using micromachined hypotubes as compression rings 214 , additional flexibility may be achieved.
- the elongate shaft 210 may have a very thin sidewall, which may be useful in terms of flexibility and profile. However, if the elongate shaft 210 has too thin of a sidewall, it can be in danger of collapsing in on itself when a vacuum is applied to the interior of the elongate shaft 210 in order to, for example, fully collapse the balloon 212 . Thus, compression rings 214 can help prevent elongate shaft 210 from collapsing on itself.
- FIG. 21 illustrates another use of a micromachined hypotube such as those discussed with respect to FIGS. 1 through 5 .
- FIG. 21 is a partial longitudinal cross-section of a balloon catheter 216 .
- the balloon catheter 216 has a distal end 218 .
- the balloon catheter 216 includes an outer sheath 220 that extends to the distal end 218 and an inner assembly 222 including a portion that extends to the distal end 218 and a portion that does not.
- a balloon 224 is disposed on the outer sheath 220 .
- Inner assembly 222 includes a polymeric liner 224 defining a guidewire lumen 226 and an inflation lumen 228 .
- a micromachined hypotube 230 similar to any of those discussed previously, extends distally from the guidewire lumen 226 and extends to the distal end 218 of the balloon catheter 216 .
- the micromachined hypotube 230 includes at least one cutout 232 configured to accommodate at least one marker band 234 .
- the at least one marker band 234 can be of conventional construction. In some instances, the at least one marker band 234 may be a section of a micromachined hypotube, as shown in FIG. 19 .
- FIGS. 22-23 illustrate a particular embodiment in which micromachining techniques have been applied to a polymeric assembly.
- FIG. 22 illustrates a balloon 236 bonded to a shaft 238 .
- the balloon 236 and the shaft 238 may be formed of any suitable material and may be constructed by any known process.
- the balloon 236 includes a proximal waist 240 and a distal waist 242 .
- the balloon 236 may be secured to the shaft 238 by bonding the proximal waist 240 and the distal waist 242 to the shaft 238 .
- a series of cuts 244 can be formed within the proximal waist 240 and a series of cuts 246 can be formed within the distal waist 242 in order to improve flexibility.
- the series of cuts 244 and the series of cuts 246 may be formed using any suitable technique. In some instances, these cuts 244 and 246 may be formed using the micromachining techniques used to form the micromachined hypotubes discussed with respect to FIGS. 1 through 5 .
- FIGS. 24 through 27 illustrate another contemplated use of the micromachined hypotubes discussed herein.
- FIG. 24 shows an outer shaft 248 deployed over an inner shaft 250 .
- the outer shaft 248 has a distal end 252 .
- the outer shaft 248 may be a micromachined hypotube while the inner shaft 250 may be a catheter shaft or a guidewire.
- both the outer shaft 248 and the inner shaft 250 may be micromachined hypotubes such as those discussed herein.
- a collapsible cage 254 having a proximal end 256 and a distal end 258 is deployed over the inner shaft 250 proximate the distal end 252 of the outer shaft 248 .
- the proximal end 256 of the collapsible cage 254 can be secured to the distal end 252 of the outer shaft 248 while the distal end 258 of the collapsible cage 254 can be secured to an attachment point 260 (or a number of attachment points 260 ) present on the inner shaft 250 .
- the collapsible cage 254 may be welded or soldered to the outer shaft 248 and the inner shaft 250 , respectively.
- the collapsible cage 254 may be formed of a number of wires 262 formed of any suitable material such as stainless steel or nitinol.
- the outer shaft 248 and the inner shaft 250 may also be formed of stainless steel or nitinol.
- the outer shaft 248 has an inner diameter that is somewhat greater than an outer diameter of the inner shaft 250 and thus the outer shaft 248 enjoys some limited relative movement with respect to the inner shaft 250 .
- FIG. 25 illustrates how the outer shaft 248 may be locked into position relative to the inner shaft 250 .
- the outer shaft 248 has been rotated with respect to the inner shaft 250 as indicated by rotation arrow 264 .
- the collapsible cage 254 tightens as individual wires 262 twist. Once the outer shaft 248 rotates a given angular distance, any additional rotation in the same direction will cause the inner shaft 250 to rotate with the outer shaft 248 .
- FIGS. 26-27 illustrate a similar principle, but utilize a different locking mechanism.
- collapsible cage 254 has been replaced with a polymer sleeve 266 , which has a proximal end 268 and a distal end 270 .
- the polymer sleeve 266 can be formed of an electro-active polymer.
- the proximal end 268 is secured to the distal end 252 of the outer shaft 248 while the distal end 270 is secured to an attachment point 260 positioned on the inner shaft 250 .
- the outer shaft 248 has an inner diameter that is somewhat greater than an outer diameter of the inner shaft 250 and thus the outer shaft 248 enjoys some limited relative movement with respect to the inner shaft 250 .
- the inner shaft 250 may rotate somewhat with respect to the outer shaft 248 , or may in some cases translate distally or proximally with respect to the outer shaft 248 .
- FIG. 27 illustrates how the outer shaft 248 may be locked into position relative to the inner shaft 250 .
- an electrical current has been applied to the polymer sleeve 266 , thereby causing the polymer sleeve 266 to contract down onto the inner sleeve 250 and thus prevent relative rotational movement between the inner shaft 248 and the outer shaft 250 .
- a current may be transmitted to the polymer sleeve 266 via the outer shaft 248 .
- FIGS. 28-30 illustrate additional uses for the micromachined hypotubes described herein.
- FIG. 28 shows an assembly 272 that may be used, for example, as a catheter.
- the assembly 272 includes a micromachined hypotube 274 having an interior 276 .
- a polymeric liner 278 is disposed within the interior 276 .
- the polymeric liner 278 defines a lumen 280 and includes three lobes 282 .
- the three lobes 282 are configured to center the polymeric liner 278 and thus the lumen 280 within the interior 276 .
- the polymeric liner 278 may include four or more lobes 282 .
- FIG. 29 shows an assembly 284 that can be used as a catheter.
- the assembly includes a micromachined hypotube 274 having an interior 276 .
- a polymeric liner 286 is disposed within the interior 276 .
- the polymeric liner 286 defines a first lumen 288 and a second lumen 290 , and has an ovoid cross-sectional shape.
- the ovoid cross-sectional shape may, in some instances, help to center the polymeric liner 286 within the interior 276 .
- FIG. 30 shows an assembly 292 that can be used as a catheter.
- the assembly includes a micromachined hypotube 274 having an interior 276 .
- a polymeric liner 294 is disposed within the interior 276 .
- the polymeric liner 294 defines a lumen 296 and has a polygonal cross-sectional shape.
- the polygonal cross-sectional shape may, in some instances, help to center the polymeric liner 294 within the interior 276 .
- the polymeric liner 294 has a six-sided cross-section.
- the polymeric liner 294 may have a four-sided, a five-sided, a seven-sided or even an eight-sided cross-section.
- FIGS. 31 and 32 show another particular application of a micromachined hypotube such as those discussed with respect to FIGS. 1 through 5 .
- FIGS. 31 and 32 show a portion of a catheter 300 having a distal region 302 defining a distal end 304 .
- the catheter 300 includes a micromachined hypotube 306 that may be constructed as discussed with respect to the micromachined hypotubes shown in FIGS. 1 through 5 .
- the micromachined hypotube 306 may include a number of slots 308 . In some instances, all of the micromachined hypotube 306 may include slots 308 while in other cases only distinct portions may include slots 308 , depending on the flexibility requirements.
- a hypotube lumen 310 extends through the micromachined hypotube 306 to the distal end 304 thereof.
- An inflatable balloon 312 is disposed about the distal region 302 of the catheter 300 .
- An outer sheath 314 may be disposed proximal of the inflatable balloon 312 and may cover at least a portion of the distal region 302 not covered by the inflatable balloon 312 .
- the hypotube lumen 310 may be used to inflate and deflate the inflatable balloon 312 .
- the inflatable balloon 312 and the outer sheath 314 may be formed of any suitable polymeric material, such as those discussed previously.
- the outer sheath 314 abuts the inflatable balloon 312 , but it is contemplated that the outer sheath 314 may overlap a portion of the inflatable balloon 312 , or, in the alternative, a portion of the inflatable balloon 312 may overlap a portion of the outer sheath 314 .
- the hypotube lumen 310 may be sized to accommodate a guidewire (not shown).
- a distal portion of the hypotube lumen 310 include a plug or other structure to seal the interior of the hypotube lumen 310 .
- the hypotube lumen 310 may include sealing structure (not shown) adapted to permit a guidewire to pass through the sealing structure yet be at least substantially fluid tight against the guidewire.
- the catheter 300 may be configured for rapid exchange.
- the catheter 300 includes a proximal guidewire port 316 , a distal guidewire port 318 and a guidewire lumen 320 that extends from the proximal guidewire port 316 to the distal guidewire port 318 .
- the guidewire lumen 320 is seen in phantom in FIG. 32 .
- part or all of the devices described herein can include a lubricious coating.
- Lubricious coatings can improve steerability and improve lesion crossing capability.
- suitable lubricious polymers include hydrophilic polymers such as polyarylene oxides, polyvinylpyrolidones, polyvinylalcohols, hydroxy alkyl cellulosics, algins, saccharides, caprolactones, and the like, and mixtures and combinations thereof.
- Hydrophilic polymers can be blended among themselves or with formulated amounts of water insoluble compounds (including some polymers) to yield coatings with suitable lubricity, bonding, and solubility.
- portions of the devices described herein can be coated with a hydrophilic polymer or a fluoropolymer such as polytetrafluoroethylene (PTFE), better known as TEFLON®.
- PTFE polytetrafluoroethylene
Abstract
Medical devices that include micromachined hypotubes or that have themselves been micromachined can provide advantages in flexibility, strength and other desirable properties. Examples of such medical devices may include catheters such as guide catheters and balloon catheters. Such devices may also include dual shaft medical devices in which an outer shaft is reversibly lockable onto an inner shaft.
Description
- The invention relates generally to medical devices and more specifically to medical devices that include micromachined components. Such medical devices may include, for example, catheters.
- Medical devices such as catheters may be subject to a number of often conflicting performance requirements such as flexibility, strength, minimized exterior diameter, maximized interior diameter, and the like. In particular, often times there is a balance between a need for flexibility and a need for strength. Therefore, a need remains for improved medical devices such as catheters that are configured for an optimal balance between flexibility, strength, and other desired properties.
- The invention pertains to improved medical devices providing advantages in flexibility, strength and other desired properties.
- Accordingly, an example embodiment of the invention can be found in a catheter that includes an elongate tube extending from a distal region of the catheter to a proximal region of the catheter. A number of slots extending radially about the elongate tube are disposed along the elongate tube. A polymeric dual-lumen liner is disposed within the elongate tube.
- Another example embodiment of the invention can be found in a catheter that includes an elongate metal tube extending from a distal region of the catheter to a proximal region of the catheter. A number of flexibility-induced slots extending radially about the elongate metal tube are disposed along the elongate metal tube. A polymeric sleeve is disposed about the elongate metal tube while a polymeric dual-lumen liner is disposed within the elongate metal tube.
- Another example embodiment of the invention can be found in a catheter having a distal region defining a distal end and a proximal region defining a proximal end. The catheter includes a polymer sheath that extends from the distal end of the catheter to the proximal end of the catheter. A micromachined hypotube is disposed over the polymer sheath and includes a distal region defining a distal end and a proximal region defining a proximal end. The micromachined hypotube extends from the distal region of the catheter to the proximal region of the catheter such that the polymer sheath extends distally from the distal end of the micromachined hypotube. The micromachined hypotube includes a number of radially-extending, flexibility-inducing slots disposed along the micromachined hypotube.
- Another example embodiment of the invention can be found in a catheter that includes an elongate shaft and at least one micromachined marker band that is disposed within a distal region of the catheter.
- Another example embodiment of the invention can be found in a catheter that includes an elongate polymer sheath, the polymer sheath defining a lumen extending through the polymer sheath. A balloon is secured to the elongate polymer sheath within a distal region of the elongate polymer sheath. At least one micromachined compression ring is disposed proximal of the balloon within the elongate polymer sheath lumen.
- Another example embodiment of the invention can be found in a catheter that includes an inner shaft defining a guidewire lumen and an inflation lumen and an outer shaft disposed over the inner shaft such that the outer shaft extends distally beyond a distal end of the inner shaft. A balloon defining a balloon interior is disposed on the outer shaft within a distal region of the catheter. A micromachined hypotube is disposed within the guidewire lumen and extends distally through the balloon interior. The micromachined hypotube includes one or more cutouts to accommodate one or more marker bands disposed on the micromachined hypotube.
- Another example embodiment of the invention can be found in a balloon catheter that includes an elongate shaft and a balloon disposed on the elongate shaft. The balloon includes a proximal waist bonded to the elongate shaft and a distal waist bonded to the elongate shaft. The distal waist and the proximal waist each include a number of radially disposed cuts intended to improve flexibility.
- Another example embodiment of the invention can be found in a medical device that includes an outer shaft and an inner shaft disposed within the outer shaft such that the inner shaft extends beyond an outer shaft end of the outer shaft. A collapsible cage is disposed over the inner shaft. The collapsible shaft includes a first end that is attached to the outer shaft end and a second end that is attached to an attachment point on the inner shaft. The collapsible cage is moveable between a moveable position in which the outer shaft may move with respect to the inner shaft and a locked position in which the outer shaft is locked to the inner shaft and cannot move.
- Another example embodiment of the invention can be found in a medical device that includes an outer shaft and an inner shaft disposed within the outer shaft such that the inner shaft extends beyond an outer shaft end of the outer shaft. A polymer sleeve is disposed over the inner shaft. The polymer sleeve includes a first end that is attached to the outer shaft end and a second end that is attached to an attachment point on the inner shaft. The polymer sleeve is moveable between a rotation position in which the outer shaft may rotate with respect to the inner shaft and a locked position in which the outer shaft is locked to the inner shaft and cannot rotate.
- Another example embodiment of the invention can be found in a medical device that includes a micromachined hypotube having a number of radially-extending, flexibility-inducing slots disposed along the micromachined hypotube. A polymer insert is disposed within a lumen defined by the micromachined hypotube. The polymer insert has a non-round radial cross-section and includes at least one lumen disposed within the polymer insert.
- Another example embodiment of the invention can be found in a catheter that includes an elongate hypotube having a hypotube lumen. The elongate hypotube extends from a distal region of the catheter to a proximal region of the catheter and includes a number of slots disposed within the elongate hypotube. An inflatable balloon is disposed about a distal region of the elongate hypotube. An outer sheath is disposed proximal to the inflatable balloon covering at least the distal region of the elongate hypotube such that the outer sheath seals the plurality of slots so that the hypotube lumen may be used for inflating and deflating the inflatable balloon.
- Another example embodiment of the invention can be found in a micromachined hypotube that includes a first number of slots that are disposed within a first portion of the micromachined hypotube and a second number of slots that are disposed within a second portion of the micromachined hypotube. The slots extend at least partially circumferentially around the micromachined hypotube. The second number of slots include adjacent slots having a spacing therebetween that is less than a spacing between adjacent slots within the first plurality of slots.
- Another example embodiment of the invention can be found in a micromachined hypotube having a number of slots disposed within the micromachined hypotube. The slots extend from the outer surface to the inner surface and each of the number of slots include a first portion extending at an acute angle with respect to the axial axis and a second portion arranged at least substantially perpendicular to the first portion.
- Another example embodiment of the invention can be found in a micromachined hypotube that has an inner surface, an outer surface and a number of radially-extending slots disposed on the micromachined hypotube, each of the radially-extending slots having a first diameter at the inner surface and a second diameter at the outer surface, the second diameter being greater than the first diameter.
- Another example embodiment of the invention can be found in a micromachined hypotube that has an axial axis. A number of slots are disposed at least substantially perpendicular to the axial axis. At least some of the slots have a first edge and a second edge, the first edge of at least some of the slots including a button that extends toward the second edge of at least some of the slots.
- The above summary of the present invention is not intended to describe each disclosed embodiment or every implementation of the present invention. The Figures, Detailed Description and Examples which follow more particularly exemplify these embodiments.
- The invention may be more completely understood in consideration of the following detailed description of various embodiments of the invention in connection with the accompanying drawings, in which:
-
FIG. 1 is a view of a micromachined hypotube in accordance with an embodiment of the invention; -
FIG. 2 is a view of a micromachined hypotube in accordance with an embodiment of the invention; -
FIG. 3 is a view of a micromachined hypotube in accordance with an embodiment of the invention; -
FIG. 4 is a view of a micromachined hypotube in accordance with an embodiment of the invention; -
FIG. 5 is a view of a micromachined hypotube in accordance with an embodiment of the invention; -
FIG. 6 is a view of a catheter in accordance with an embodiment of the invention; -
FIG. 7 is a partial longitudinal cross-sectional view of a proximal portion of the catheter ofFIG. 6 ; -
FIG. 8 is a partial longitudinal cross-sectional view of an intermediate portion of the catheter ofFIG. 6 ; -
FIG. 9 is a partial longitudinal cross-sectional view of a distal portion of the catheter ofFIG. 6 ; -
FIG. 10 is a cross-sectional view taken along line 10-10 ofFIG. 6 ; -
FIG. 11 is a cross-sectional view taken along line 11-11 ofFIG. 6 ; -
FIG. 12 is a view of a catheter in accordance with an embodiment of the invention; -
FIG. 13 is a cross-sectional view taken along line 13-13 ofFIG. 12 ; -
FIG. 14 is a cross-sectional view taken along line 14-14 ofFIG. 12 ; -
FIG. 15 is a partial longitudinal view of structure present within the catheter ofFIG. 12 ; -
FIG. 16 is a view of a catheter in accordance with an embodiment of the invention; -
FIG. 17 is a cross-sectional view taken along line 17-17 ofFIG. 16 ; -
FIG. 18 is a cross-sectional view taken along line 18-18 ofFIG. 16 ; -
FIG. 19 is a view of a portion of a catheter in accordance with an embodiment of the invention; -
FIG. 20 is a view of a portion of a catheter in accordance with an embodiment of the invention; -
FIG. 21 is a view of a portion of a catheter in accordance with an embodiment of the invention; -
FIG. 22 is a view of a balloon bonded to a catheter shaft in accordance with an embodiment of the invention; -
FIG. 23 is a view of the balloon ofFIG. 22 , illustrating post-attachment processing in accordance with an embodiment of the invention; -
FIG. 24 is a view of an assembly including outer shaft attached to an inner shaft via a collapsible cage in accordance with an embodiment of the invention; -
FIG. 25 is a view of the assembly ofFIG. 24 , shown with the cage in a collapsed configuration in accordance with an embodiment of the invention; -
FIG. 26 is a view of an assembly including an outer shaft attached to an inner shaft via a collapsible electroactive polymer sleeve in accordance with an embodiment of the invention; -
FIG. 27 is a view of the assembly ofFIG. 26 , shown with the electroactive polymer sleeve in a collapsed configuration in accordance with an embodiment of the invention; -
FIG. 28 is a view of an assembly in accordance with an embodiment of the invention; -
FIG. 29 is a view of an assembly in accordance with an embodiment of the invention; -
FIG. 30 is a view of an assembly in accordance with an embodiment of the invention; -
FIG. 31 is a view of a portion of a catheter in accordance with an embodiment of the invention; and -
FIG. 32 is a view of a portion of a catheter in accordance with an embodiment of the invention. - While the invention is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail. It should be understood, however, that the intention is not to limit the invention to the particular embodiments described. On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.
- For the following defined terms, these definitions shall be applied, unless a different definition is given in the claims or elsewhere in this specification.
- All numeric values are herein assumed to be modified by the term “about”, whether or not explicitly indicated. The term “about” generally refers to a range of numbers that one of skill in the art would consider equivalent to the recited value (i.e., having the same function or result). In many instances, the terms “about” may include numbers that are rounded to the nearest significant figure.
- The recitation of numerical ranges by endpoints includes all numbers within that range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5).
- As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include plural referents unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.
- The following description should be read with reference to the drawings wherein like reference numerals indicate like elements throughout the several views. The drawings, which are not necessarily to scale, depict illustrative embodiments of the claimed invention.
- The invention pertains generally to medical devices that include micromachined hypotubes or other elements that have been micromachined. A variety of micromachined hypotubes are within the scope of the invention and are useful in the medical devices described herein.
FIGS. 1-5 illustrate particular, but non-limiting, micromachined hypotubes as contemplated within the boundaries of the invention. -
FIG. 1 illustrates amicromachined hypotube 10 having aproximal region 12 defining aproximal end 14 and adistal region 16 defining adistal end 18. Themicromachined hypotube 10 can be seen as having anaxial axis 20 extending the length of thehypotube 10. One ormore slots 22 are disposed along the length of themicromachined hypotube 10. In the illustrated embodiment, theslots 22 are arranged at least substantially perpendicular to theaxial axis 20. In other instances, theslots 22 may be arranged at an angle with respect to theaxial axis 20, or may even be parallel to theaxial axis 20. - Each of the
slots 22 extend only partially around the circumference of themicromachined hypotube 10. In some instances, anindividual slot 22 may extend about half way around the circumference of the micromachined hypotube. In other cases, anindividual slot 22 can extend more than halfway around, if for example, increased flexibility is of highest importance. Conversely, if it is desired to provide additional column strength, perhaps with a certain sacrifice in flexibility, it is contemplated that eachindividual slot 22 may extend less than halfway around themicromachined hypotube 10. - If an
individual slot 22 extends only a relatively short circumferential difference about themicromachined hypotube 10, it is contemplated that two, three ormore slots 22 may be disposed radially about a single axial position along themicromachined hypotube 10. In some instances, anindividual slot 22 may extend completely through the micromachined hypotube. In some cases, one or more of theindividual slots 22 may have a depth less than a wall thickness of themicromachined hypotube 10. - It can be seen that
individual slots 22 may be considered as being inpairs 24, with apair 24 including afirst slot 26 and asecond slot 28. In some embodiments, as illustrated, thefirst slot 26 can have a first radial position on themicromachined hypotube 10 while thesecond slot 28 occupies a second radial position that is rotated from the first radial position. In some embodiments, as illustrated, thesecond slot 28 can be rotated about 90 degrees from thefirst slot 26. In other instances, the radial rotation can vary, especially if, for example,first slot 26 andfirst slot 28 are either longer or shorter than the illustrated length. - In some instances, and as illustrated, an
individual slot 22 may be rectangular in shape. In some instances, anindividual slot 22 may be curved, such as a semi-circular shape. In some cases, anindividual slot 22 may be diamond-shaped. Anindividual slot 22 may be formed using any suitable technique, such as saw cutting, a laser, or even by electrical discharge machining (EDM). Additional suitable techniques include chemical etching and abrasive grinding. - The
micromachined hypotube 10 may be formed of any suitable polymeric or metallic material. In some cases, themicromachined hypotube 10 may be formed of a suitably stiff polymer such as carbon fibers, liquid crystal polymers, polyimide, and the like. In some instances, themicromachined hypotube 10 may be formed of a metallic material such as stainless steel or a nickel-titanium alloy such as Nitinol or other metallic or polymeric shape-memory material. Themicromachined hypotube 10 may include a combination of metal tubes and polymer tubes, if desired. - The
micromachined hypotube 10 may be formed having any desired length, width, material thickness, and slot size as required to satisfy the requirements of any particular application. Additional details concerningmicromachined hypotube 10, including the manufacture thereof, can be found, for example, in U.S. Pat. No. 6,766,720 and published U.S. Patent Application No. 2004/0181174A2, each of which are fully incorporated, in their entirety, by reference herein. - In
FIG. 1 , each of theslots 22 disposed withinmicromachined hypotube 10 are evenly axially spaced.FIG. 2 illustrates an embodiment in which the inter-slot spacing is varied. - In particular,
FIG. 2 shows amicromachined hypotube 30 having aproximal region 32 defining aproximal end 34 and adistal region 36 defining adistal end 38. Themicromachined hypotube 30 has anaxial axis 40 extending the length of thehypotube 30. A number of slots 42 are disposed along the length of themicromachined hypotube 10. In the illustrated embodiment, the slots 42 are arranged at least substantially perpendicular to theaxial axis 40. In other instances, the slots 42 may be arranged at an angle with respect to theaxial axis 40. - Each of the slots 42 extend only partially around the circumference of the
micromachined hypotube 30. In some instances, an individual slot 42 may extend about half way around the circumference of the micromachined hypotube. In other cases, an individual slot 42 can either extend less than halfway around, or conversely, more than halfway around, depending on the relative importance of flexibility and strength. As discussed with respect toFIG. 1 , individual slots 42 can be radially offset from adjacent slots 42. - As noted,
FIG. 2 illustrates variety in inter-slot spacing. In theproximal region 32, for example, individual slots 42 may be considered as being inpairs 44, with apair 44 including afirst slot 46 and asecond slot 48. Similarly, in thedistal region 36, individual slots may be considered as being inpairs 50, with apair 50 including afirst slot 52 and asecond slot 54. It can be seen inFIG. 2 that the axial spacing betweenfirst slot 46 andsecond slot 48 ofpair 44 is greater than the axial spacing betweenfirst slot 52 andsecond slot 54 ofpair 50. This can be done to provide relatively greater flexibility within thedistal region 36. - In some instances, the inter-slot spacing within the
proximal region 32 may be a first constant while the inter-slot spacing within thedistal region 36 may be a second, smaller constant. In some cases, the inter-slot spacing may change on a step-wise fashion moving from theproximal region 32 to thedistal region 36. In some instances, the inter-slot spacing may change in a more continuous manner when moving from theproximal region 32 to thedistal region 36. -
FIG. 3 illustrates another exemplary slot pattern. In particular,FIG. 3 shows amicromachined hypotube 56 having aproximal region 58 and adistal region 60. Anaxial axis 62 extends through themicromachined hypotube 56. Themicromachined hypotube 56 includes a number of slots 64. Each slot 64 can be seen to include a first portion 66, asecond portion 68 and an interveningapex 70. In some instances, as illustrated, the apex 70 of several axially aligned slots 64 may be seen to lie along aline 72 that is parallel with theaxial axis 62. - It can be seen that the first portion 66 forms an acute angle with the
line 72, while thesecond portion 68 is at least substantially perpendicular to the first portion 66. In some instances, the first portion 66 and thesecond portion 68 may form similar angles with theline 72 yet form an angle of less than about 90 degrees between the first portion 66 and thesecond portion 68. In other instances, the first portion 66 and thesecond portion 68 may form an angle between themselves that is greater than about 90 degrees. As discussed previously with respect toFIGS. 1 and 2 , adjacent slots 64 may be radially offset. -
FIG. 4 illustrates amicromachined hypotube 74 that has adistal region 76 defining adistal end 78 and aproximal region 80 defining aproximal end 82. The micromachined hypotube defines anaxial axis 84 extending therethrough. Themicromachined hypotube 74 has aninner surface 86 and anouter surface 88. A number of taperedslots 90 are disposed within the micromachined hypotube 74 and are at least substantially radially aligned, i.e. are at least substantially perpendicular to theaxial axis 84. As discussed previously with respect toFIGS. 1 and 2 , adjacenttapered slots 90 may be radially offset. - The
tapered slots 90 can be seen to have opposinglower edges 92 atinner surface 86 and opposingupper edges 94 atouter surface 88. Thetapered slots 90 are constructed such that each taperedslot 90 has a major dimension that is at least substantially perpendicular to theaxial axis 84 and a minor dimension that is orthogonal to the major dimension. In some instances, the major dimension may be considered to be a length of the taperedslot 90, while the minor dimension may be considered to be a width of the tapered slot. In some instances, as illustrated, each taperedslot 90 has a minor dimension, or width between opposingupper edges 94, at theouter surface 88 that is larger than the minor dimension, or width between opposinglower edges 92, of the same taperedslot 90 at theinner surface 86. In some cases, the width of the taperedslot 90 at theouter surface 88 can be about twice the correspondinginner surface 86 width. - As a result of tapered
slots 90 having a relatively wider opening at theouter surface 88, relatively greater flexibility can be obtained inmicromachined hypotube 74 as themicromachined hypotube 74 can bend further before opposingupper edges 94 come into contact with each other. As a result of providingtapered slots 90 with a relatively narrower opening at theinner surface 86, relatively greater column strength may be obtained inmicromachined hypotube 74 as the bottom edges of the taperedslot 90 will contact each other as compressive force is applied to themicromachined hypotube 74. By varying the relative distance between opposinglower edges 92 and the corresponding opposingupper edges 94, a balance between flexibility and strength may be optimized for any particular application. - In some instances, as illustrated, the ends of each tapered
slot 90 may be similarly tapered. In other cases, the slot ends may not be tapered. Each of the taperedslots 90 extend only partially around the circumference of themicromachined hypotube 74. In some instances, an individual taperedslot 90 may extend about half way around the circumference of themicromachined hypotube 74. In other cases, an individual taperedslot 90 can either extend less than halfway around, or conversely, more than halfway around, depending on the relative importance of flexibility and strength. As discussed with respect toFIG. 1 , individual taperedslots 90 can be radially offset from adjacent taperedslots 90. -
FIG. 5 shows amicromachined hypotube 96 having aproximal region 98 defining aproximal end 100 and adistal region 102 defining adistal region 104. Anaxial axis 106 extends through themicromachined hypotube 96. A number ofslots 108 are disposed within the micromachined hypotube 96 and are at least substantially radially aligned, i.e. are at least substantially perpendicular to theaxial axis 106. As discussed previously with respect toFIGS. 1 and 2 ,adjacent slots 108 may be radially offset. - Each of the
slots 108 can be seen as including aproximal edge 110 and adistal edge 112. Some of theslots 108 may include a protrusion orbutton 114 on at least one of theproximal edge 110 and thedistal edge 112. Thesebuttons 114 may be integrally formed withmicromachined hypotube 96. In some instances, thebuttons 114 can be added subsequently to forming themicromachined hypotube 96. In such cases, it is contemplated thatbuttons 114 could include or be formed from small amounts of molten material such as solder, or perhaps the stainless steel or even nitinol from which themicromachined hypotube 96 was formed. In some instances, thebuttons 114 may be formed via electrical discharge machining (EDM). - In some instances, as illustrated, the
buttons 114 may be provided or formed alongproximal edge 110 of theslots 108. In other cases,buttons 114 could be included along thedistal edge 112 of theslots 108. It is contemplated thatbuttons 114 could be provided along theproximal edge 110 of some of theslots 108 and along thedistal edge 112 of some of theother slots 108. The number and placement of thebuttons 114 can be varied to achieve a desired level of column support. -
FIGS. 6 through 11 illustrate an example use of themicromachined hypotubes FIG. 6 shows acatheter 116 having aproximal region 118 defining aproximal end 120 and adistal region 122 defining adistal end 124.Catheter 116 can be one of a variety of different catheters, but is preferably an intravascular catheter. Examples of intravascular catheters include balloon catheters, atherectomy catheters, stent delivery catheters such as those adapted to deploy self-expanding stents, filter delivery catheters, diagnostic catheters and guide catheters. As illustrated,FIG. 6 portrays a balloon catheter, but the invention is not limited to such. Ahub 126 is secured to thecatheter 116 near theproximal end 120. Aballoon 128 is secured to thecatheter 116 within thedistal region 124. Thehub 126 and theballoon 128 can be of any known construction. - In the illustrated embodiment, a
guidewire port 130 is disposed within thecatheter 116 at a position proximal of theballoon 128 but well distal of thehub 126. Theguidewire port 130 can be positioned relatively close to thedistal end 124 of thecatheter 116 to providecatheter 116 with rapid exchange capabilities, even if a guidewire lumen (not illustrated in this view) extends throughout the length of thecatheter 116. - In some embodiments, the
catheter 116 includes anelongate shaft 132 extending from thehub 126 to at least thedistal region 122, if not thedistal end 124, of thecatheter 116. Theelongate shaft 132 may be of any suitable material. In some instances, theelongate shaft 132 may be a micromachined hypotube such as those described with respect toFIGS. 1-5 . The slots are not shown inFIG. 6 , simply for clarity. As will be discussed with respect toFIGS. 9 and 10 , thecatheter 116 may include one more polymeric elements within an interior of theelongate shaft 132. -
FIG. 7 is a partial cross-sectional view of a portion of theproximal region 118, including a portion ofhub 126. Amicromachined hypotube 134 can be seen as extending distally out of thehub 126. Similar to several of the micromachined hypotubes discussed previously,micromachined hypotube 134 includes a number of radially-orientedslots 135. Whileslots 135 are shown as being similar to those shown inFIG. 1 , it should be recognized that a number of other arrangements are contemplated. - The
micromachined hypotube 134 also includesseveral apertures 136. One ormore apertures 136 may be spaced about the circumference of themicromachined hypotube 134. In some embodiments, a total of fourapertures 136 may be equally spaced about the circumference of themicromachined hypotube 134. In other instances, either fewer than four or perhaps even more than fourapertures 136 may be included. While the illustratedapertures 136 are round, other shapes are contemplated. - The
apertures 136 are included within themicromachined hypotube 134 in order to provide for additional attachment points between the micromachined hypotube 134 and the polymeric liner (which will be discussed in greater detail hereinafter) positioned within themicromachined hypotube 134. In some instances, additional polymeric material may be melted into theapertures 136 to secure the polymeric liner to themicromachined hypotube 134. -
FIG. 8 shows another section of themicromachined hypotube 134, corresponding to either side of the guidewire port 130 (FIG. 7 ). This portion of themicromachined hypotube 134 includes aguidewire aperture 138 that is configured and positioned to align with theguidewire port 130 and thus permit access to the interior of themicromachined hypotube 134. It should be recognized that theguidewire aperture 138 may be somewhat generalized inFIG. 8 , and may have a curved or semicircular shape, depending on how it is formed. One ormore apertures 140 can be positioned just proximal of theguidewire aperture 138 and one ormore apertures 142 can be positioned just distal of theguidewire aperture 138. - The
apertures micromachined hypotube 134. In some embodiments, a total of fourapertures 140 and a total of fourapertures 142 may be equally spaced about the circumference of themicromachined hypotube 134. In other instances, either fewer than four or perhaps even more than four ofapertures apertures - The
apertures micromachined hypotube 134 in order to provide for additional attachment points between the micromachined hypotube 134 and the polymeric liner positioned therein. In some instances, additional polymeric material may be melted into theapertures micromachined hypotube 134. -
FIG. 9 is a partial cross-section view of a portion of thedistal region 122, showing themicromachined hypotube 134 as well as a portion of theballoon 128. One ormore apertures 144 can be positioned just proximal of aproximal end 146 of theballoon 128. Theapertures 144 may be spaced about the circumference of themicromachined hypotube 134. In some embodiments, a total of fourapertures 144 may be equally spaced about the circumference of themicromachined hypotube 134. In other instances, either fewer than four or perhaps even more than four ofapertures 144 may be included. While the illustratedapertures 144 are round, other shapes are contemplated. - The
apertures 144 are included within themicromachined hypotube 134 in order to provide for additional attachment points between the micromachined hypotube 134 and the polymeric liner positioned therein. In some instances, additional polymeric material may be melted into theapertures 144 to secure the polymeric liner to themicromachined hypotube 134. -
FIG. 10 is a cross-section ofFIG. 6 , taken along line 10-10, illustrating the construction of the elongate shaft 132 (FIG. 6 ). Apolymeric liner 148 can be seen positioned withinmicromachined hypotube 134. In the illustrated embodiment, thepolymeric liner 148 includes aguidewire lumen 150 and aninflation lumen 152. In some instances, thepolymeric liner 148 could include either a greater or lesser number of lumens, as dictated by the intended use of catheter 116 (FIG. 6 ). - The
polymeric liner 148 can be made of any suitable polymeric material. Examples of suitable materials include polyethylene, polyurethane, elastomeric polyamides, block polyamide/ethers (such as PEBAX®), silicones, co-polymers, thermoplastic polymers such as a co-polyester thermoplastic elastomer such as that available commercially under the ARNITEL® name, and fluoropolymers such as PTFE. In particular embodiments, thepolymeric liner 148 may be formed of high density polyethylene. If thepolymeric liner 148 is formed of high density polyethylene, the same material may be used to melt into apertures 136 (FIG. 7 ),apertures 140 and 142 (FIG. 8 ) and apertures 144 (FIG. 9 ), in order to securepolymeric liner 148 tomicromachined hypotube 134. -
FIG. 11 is a cross-section ofFIG. 6 , taken along line 11-11, illustrating additional construction details of the elongate shaft 132 (FIG. 6 ) as pertaining to the guidewire port (136). InFIG. 11 , the micromachined hypotube 134 and thepolymeric liner 148 have been milled, ground, or otherwise processed or provide anopening 154 that permits access to theguidewire lumen 150 from a position exterior to thecatheter 116. -
FIGS. 12-15 illustrate another example use of themicromachined hypotubes FIG. 12 shows acatheter 156 having aproximal region 158 defining aproximal end 160 and adistal region 162 defining adistal end 164.Catheter 156 can be one of a variety of different catheters, but is preferably an intravascular catheter. Examples of intravascular catheters include balloon catheters, atherectomy catheters, stent delivery catheters, filter delivery catheters, diagnostic catheters and guide catheters. -
Catheter 156 can include one or more constructional elements, as will be discussed. As illustrated, thecatheter 156 includes aguidewire lumen 168 and aninflation lumen 170, although in someinstances catheter 156 can include additional lumens. In some cases,catheter 156 may only include a single lumen that can be used both as a guidewire lumen and as an inflation lumen, shouldcatheter 156 be a balloon catheter. For clarity, a balloon is not illustrated inFIG. 12 . Thecatheter 156 also includes aguidewire port 166 that provides access to the interior of theguidewire lumen 168. -
FIGS. 13 and 14 are cross-sections taken throughFIG. 12 .FIG. 13 is taken through theproximal region 158 ofFIG. 12 whileFIG. 14 is taken through thedistal region 162 ofFIG. 12 . As shown inFIG. 13 , thecatheter 156 can be seen to include aninner polymeric liner 172 that definesguidewire lumen 168 andinflation lumen 170, anouter polymeric sheath 176 and an interveningmicromachined hypotube 174. Themicromachined hypotube 174 can include any construction discussed herein with respect to position, configuration and frequency of slots. - In
FIG. 14 , which is a cross-section taken distally of the guidewire port 166 (FIG. 12 ), it can be seen that only a portion of themicromachined hypotube 174 remains. In particular, the upper portion, which would otherwise interfere with a guidewire (not illustrated) gaining access to theguidewire lumen 168, has been removed. -
FIG. 15 is a side view of themicromachined hypotube 174, which has aproximal end 178, adistal region 180 and adistal end 182. It can be seen that much of the material has been removed in thedistal region 180, formingprofile 184. In some instances, the material can be removed from thedistal region 180 using any suitable technique such as grinding, cutting, laser and the like. In some cases, it is contemplated thatprofile 184 can instead be formed by crushing thedistal region 180 of themicromachined hypotube 174, rather than material removal. This may necessitate, however, drilling or otherwise forming an aperture through the crushed portion to permit a guidewire (not shown) to pass from the interior of themicromachined hypotube 174 to the exterior of themicromachined hypotube 174 as the guidewire passes into theprofile 184. -
FIG. 16-18 illustrate another example use of the micromachined hypotubes discussed herein.FIG. 16 shows acatheter 186 having aproximal region 188 defining aproximal end 190 and adistal region 192 defining adistal end 194. As illustrated,catheter 186 is an over-the-wire, or single-operator-exchange (SOE) catheter, but is not limited to such. Thecatheter 186 includes apolymeric sheath 196 that extends from theproximal end 190 to thedistal end 194. Micromachined hypotube 32 (FIG. 2 ) is seen deployed overpolymeric sheath 196, as also illustrated inFIGS. 17 and 18 . - The
polymeric sheath 196 may be formed of any suitable polymeric material. Examples of suitable materials include polyethylene, polyurethane including high density polyurethane, elastomeric polyamides, block polyamide/ethers (such as PEBAX®), silicones, co-polymers, thermoplastic polymers such as a co-polyester thermoplastic elastomer such as that available commercially under the ARNITEL® name, and fluoropolymers such as PTFE. - In some instances, the
polymeric sheath 196 may be formed of particular materials and to particular dimensions such that thepolymeric sheath 196 is highly flexible but lacks sufficient column strength for pushing thecatheter 186 through a body lumen. Themicromachined hypotube 32 provides a desired level of column strength without excessively impacting flexibility. - In some instances, the
distal end 38 of themicromachined hypotube 32 may be positioned proximal of thedistal end 194 of thecatheter 186 in order to not impact the flexibility of thedistal end 194. In some cases, thedistal end 38 of the micromachined 32 may be positioned at least about 4 centimeters from thedistal end 194 and no more than about 20 centimeters from thedistal end 194. If thedistal end 38 of themicromachined hypotube 32 is too far from thedistal end 194 of thecatheter 186, pushability may suffer. Conversely, if thedistal end 38 is too close todistal end 194, flexibility can suffer. - As illustrated, the
proximal end 34 of themicromachined hypotube 32 ends at a position that is distal to theproximal end 190 of thecatheter 186. In some instances, themicromachined hypotube 32 may extend further proximally such that theproximal end 34 is adjacent to or even proximal of theproximal end 190 of thecatheter 186. It is contemplated that extending themicromachined hypotube 32 proximally of theproximal end 190 of thecatheter 186 may provide handling advantages. -
FIG. 19 illustrates a particular application of a micromachined hypotube as contemplated herein. InFIG. 19 , adistal portion 200 of acatheter 198 is shown. Thecatheter 198 may be any particular intravascular catheter and can include one ormore marker bands 202.Marker bands 202 are unique in that they are sections of micromachined hypotubes such as those discussed with respect toFIGS. 1 through 5 . By using micromachined hypotubes asmarker bands 202, additional flexibility may be achieved.Marker bands 202 may be formed of any suitably radiopaque material, such as gold, platinum, palladium, tantalum, tungsten alloy, and the like. -
FIG. 20 illustrates another particular application of a micromachined hypotube such as those discussed with respect toFIGS. 1 through 5 .FIG. 20 is a partial longitudinal cross-section of adistal portion 206 of aballoon catheter 204 having adistal end 208. Theballoon catheter 204 includes anelongate shaft 210 and aballoon 212 disposed on the elongate shaft. One or more compression rings 214 are positioned within theelongate shaft 210, proximal of theballoon 212. The compression rings 214 are unique in that they are sections of micromachined hypotubes such as those discussed with respect toFIGS. 1 through 5 . By using micromachined hypotubes as compression rings 214, additional flexibility may be achieved. - In some instances, the
elongate shaft 210 may have a very thin sidewall, which may be useful in terms of flexibility and profile. However, if theelongate shaft 210 has too thin of a sidewall, it can be in danger of collapsing in on itself when a vacuum is applied to the interior of theelongate shaft 210 in order to, for example, fully collapse theballoon 212. Thus, compression rings 214 can help preventelongate shaft 210 from collapsing on itself. -
FIG. 21 illustrates another use of a micromachined hypotube such as those discussed with respect toFIGS. 1 through 5 .FIG. 21 is a partial longitudinal cross-section of a balloon catheter 216. The balloon catheter 216 has adistal end 218. The balloon catheter 216 includes anouter sheath 220 that extends to thedistal end 218 and aninner assembly 222 including a portion that extends to thedistal end 218 and a portion that does not. Aballoon 224 is disposed on theouter sheath 220. -
Inner assembly 222 includes apolymeric liner 224 defining aguidewire lumen 226 and aninflation lumen 228. Amicromachined hypotube 230, similar to any of those discussed previously, extends distally from theguidewire lumen 226 and extends to thedistal end 218 of the balloon catheter 216. Themicromachined hypotube 230 includes at least onecutout 232 configured to accommodate at least onemarker band 234. The at least onemarker band 234 can be of conventional construction. In some instances, the at least onemarker band 234 may be a section of a micromachined hypotube, as shown inFIG. 19 . -
FIGS. 22-23 illustrate a particular embodiment in which micromachining techniques have been applied to a polymeric assembly. In particular,FIG. 22 illustrates aballoon 236 bonded to ashaft 238. Theballoon 236 and theshaft 238 may be formed of any suitable material and may be constructed by any known process. Theballoon 236 includes aproximal waist 240 and adistal waist 242. In some instances, theballoon 236 may be secured to theshaft 238 by bonding theproximal waist 240 and thedistal waist 242 to theshaft 238. - While bonding the
proximal waist 240 and thedistal waist 242 to theshaft 238 provides an appropriate attachment method, there may be flexibility issues caused by the increased material thickness present at theproximal waist 240 and thedistal waist 242. Thus, as illustrated inFIG. 23 , a series ofcuts 244 can be formed within theproximal waist 240 and a series ofcuts 246 can be formed within thedistal waist 242 in order to improve flexibility. The series ofcuts 244 and the series ofcuts 246 may be formed using any suitable technique. In some instances, thesecuts FIGS. 1 through 5 . -
FIGS. 24 through 27 illustrate another contemplated use of the micromachined hypotubes discussed herein. In some instances, there may be a desire to have an outer shaft at least somewhat free to move with respect to an inner shaft, yet be able to lock the outer shaft with respect to the inner shaft when necessary. -
FIG. 24 shows anouter shaft 248 deployed over aninner shaft 250. Theouter shaft 248 has adistal end 252. As illustrated, theouter shaft 248 may be a micromachined hypotube while theinner shaft 250 may be a catheter shaft or a guidewire. In some instances, both theouter shaft 248 and theinner shaft 250 may be micromachined hypotubes such as those discussed herein. - A
collapsible cage 254 having aproximal end 256 and adistal end 258 is deployed over theinner shaft 250 proximate thedistal end 252 of theouter shaft 248. Theproximal end 256 of thecollapsible cage 254 can be secured to thedistal end 252 of theouter shaft 248 while thedistal end 258 of thecollapsible cage 254 can be secured to an attachment point 260 (or a number of attachment points 260) present on theinner shaft 250. In some instances, thecollapsible cage 254 may be welded or soldered to theouter shaft 248 and theinner shaft 250, respectively. - The
collapsible cage 254 may be formed of a number ofwires 262 formed of any suitable material such as stainless steel or nitinol. Similarly, theouter shaft 248 and theinner shaft 250 may also be formed of stainless steel or nitinol. - As illustrated, the
outer shaft 248 has an inner diameter that is somewhat greater than an outer diameter of theinner shaft 250 and thus theouter shaft 248 enjoys some limited relative movement with respect to theinner shaft 250.FIG. 25 illustrates how theouter shaft 248 may be locked into position relative to theinner shaft 250. - In
FIG. 25 , theouter shaft 248 has been rotated with respect to theinner shaft 250 as indicated byrotation arrow 264. As theouter shaft 248 rotates with respect to theinner shaft 250, thecollapsible cage 254 tightens asindividual wires 262 twist. Once theouter shaft 248 rotates a given angular distance, any additional rotation in the same direction will cause theinner shaft 250 to rotate with theouter shaft 248. -
FIGS. 26-27 illustrate a similar principle, but utilize a different locking mechanism. InFIG. 26 ,collapsible cage 254 has been replaced with apolymer sleeve 266, which has aproximal end 268 and adistal end 270. Thepolymer sleeve 266 can be formed of an electro-active polymer. Theproximal end 268 is secured to thedistal end 252 of theouter shaft 248 while thedistal end 270 is secured to anattachment point 260 positioned on theinner shaft 250. - As illustrated, the
outer shaft 248 has an inner diameter that is somewhat greater than an outer diameter of theinner shaft 250 and thus theouter shaft 248 enjoys some limited relative movement with respect to theinner shaft 250. Theinner shaft 250 may rotate somewhat with respect to theouter shaft 248, or may in some cases translate distally or proximally with respect to theouter shaft 248.FIG. 27 illustrates how theouter shaft 248 may be locked into position relative to theinner shaft 250. - In
FIG. 27 , an electrical current has been applied to thepolymer sleeve 266, thereby causing thepolymer sleeve 266 to contract down onto theinner sleeve 250 and thus prevent relative rotational movement between theinner shaft 248 and theouter shaft 250. In some instances, a current may be transmitted to thepolymer sleeve 266 via theouter shaft 248. -
FIGS. 28-30 illustrate additional uses for the micromachined hypotubes described herein.FIG. 28 shows anassembly 272 that may be used, for example, as a catheter. Theassembly 272 includes amicromachined hypotube 274 having an interior 276. A polymeric liner 278 is disposed within theinterior 276. In the illustrated embodiment, the polymeric liner 278 defines alumen 280 and includes threelobes 282. In some instances, the threelobes 282 are configured to center the polymeric liner 278 and thus thelumen 280 within theinterior 276. In other embodiments, the polymeric liner 278 may include four ormore lobes 282. -
FIG. 29 shows anassembly 284 that can be used as a catheter. The assembly includes amicromachined hypotube 274 having an interior 276. Apolymeric liner 286 is disposed within theinterior 276. Thepolymeric liner 286 defines afirst lumen 288 and asecond lumen 290, and has an ovoid cross-sectional shape. The ovoid cross-sectional shape may, in some instances, help to center thepolymeric liner 286 within theinterior 276. -
FIG. 30 shows anassembly 292 that can be used as a catheter. The assembly includes amicromachined hypotube 274 having an interior 276. Apolymeric liner 294 is disposed within theinterior 276. Thepolymeric liner 294 defines alumen 296 and has a polygonal cross-sectional shape. The polygonal cross-sectional shape may, in some instances, help to center thepolymeric liner 294 within theinterior 276. In the illustrated embodiment, thepolymeric liner 294 has a six-sided cross-section. In some instances, thepolymeric liner 294 may have a four-sided, a five-sided, a seven-sided or even an eight-sided cross-section. -
FIGS. 31 and 32 show another particular application of a micromachined hypotube such as those discussed with respect toFIGS. 1 through 5 .FIGS. 31 and 32 show a portion of acatheter 300 having adistal region 302 defining adistal end 304. Thecatheter 300 includes amicromachined hypotube 306 that may be constructed as discussed with respect to the micromachined hypotubes shown inFIGS. 1 through 5 . Themicromachined hypotube 306 may include a number ofslots 308. In some instances, all of themicromachined hypotube 306 may includeslots 308 while in other cases only distinct portions may includeslots 308, depending on the flexibility requirements. - A
hypotube lumen 310 extends through themicromachined hypotube 306 to thedistal end 304 thereof. Aninflatable balloon 312 is disposed about thedistal region 302 of thecatheter 300. Anouter sheath 314 may be disposed proximal of theinflatable balloon 312 and may cover at least a portion of thedistal region 302 not covered by theinflatable balloon 312. As a result, thehypotube lumen 310 may be used to inflate and deflate theinflatable balloon 312. Theinflatable balloon 312 and theouter sheath 314 may be formed of any suitable polymeric material, such as those discussed previously. As shown, theouter sheath 314 abuts theinflatable balloon 312, but it is contemplated that theouter sheath 314 may overlap a portion of theinflatable balloon 312, or, in the alternative, a portion of theinflatable balloon 312 may overlap a portion of theouter sheath 314. - In some instances, the
hypotube lumen 310 may be sized to accommodate a guidewire (not shown). In a fixed wire configuration, it is contemplated that a distal portion of thehypotube lumen 310 include a plug or other structure to seal the interior of thehypotube lumen 310. In an over-the-wire configuration, it is contemplated that thehypotube lumen 310 may include sealing structure (not shown) adapted to permit a guidewire to pass through the sealing structure yet be at least substantially fluid tight against the guidewire. - In some instances, as shown for example in
FIG. 32 , thecatheter 300 may be configured for rapid exchange. In this embodiment, thecatheter 300 includes aproximal guidewire port 316, adistal guidewire port 318 and aguidewire lumen 320 that extends from theproximal guidewire port 316 to thedistal guidewire port 318. Theguidewire lumen 320 is seen in phantom inFIG. 32 . - In some embodiments, part or all of the devices described herein can include a lubricious coating. Lubricious coatings can improve steerability and improve lesion crossing capability. Examples of suitable lubricious polymers include hydrophilic polymers such as polyarylene oxides, polyvinylpyrolidones, polyvinylalcohols, hydroxy alkyl cellulosics, algins, saccharides, caprolactones, and the like, and mixtures and combinations thereof. Hydrophilic polymers can be blended among themselves or with formulated amounts of water insoluble compounds (including some polymers) to yield coatings with suitable lubricity, bonding, and solubility. In some embodiments, portions of the devices described herein can be coated with a hydrophilic polymer or a fluoropolymer such as polytetrafluoroethylene (PTFE), better known as TEFLON®.
- It should be understood that this disclosure is, in many respects, only illustrative. Changes may be made in details, particularly in matters of shape, size, and arrangement of steps without exceeding the scope of the invention. The invention's scope is, of course, defined in the language in which the appended claims are expressed.
Claims (21)
1. (canceled)
2. A medical device comprising:
an outer shaft having a proximal end and a distal end;
an inner shaft movably disposed within the outer shaft, a distal end of the inner shaft extending beyond the distal end of the outer shaft; and
an actuatable means for locking the inner shaft to the outer shaft, thereby preventing relative movement therebetween;
wherein the means for locking is fixedly attached to the outer shaft.
3. The medical device of claim 2 , wherein the means for locking includes a collapsible cage disposed over the inner shaft, the collapsible cage comprising a first end attached to the distal end of the outer shaft and a second end attached to at least one attachment point on the inner shaft;
wherein the collapsible cage is actuatable between a unlocked position in which the outer shaft may translate with respect to the inner shaft and a locked position in which the outer shaft is locked to the inner shaft and cannot translate.
4. The medical device of claim 3 , wherein the collapsible cage comprises a plurality of strands, each strand having a first end attached to the distal end of the outer shaft and a second end attached to one attachment point on the inner shaft.
5. The medical device of claim 3 , wherein the collapsible cage is configured to be actuatable between the unlocked position and the locked position by rotating the outer shaft a predetermined distance with respect to the inner shaft.
6. The medical device of claim 4 , wherein each of the plurality of strands is formed of a metallic wire.
7. The medical device of claim 6 , wherein each of the plurality of strands is attached to the outer shaft and the inner shaft by welding or soldering.
8. The medical device of claim 2 , wherein the means for locking includes a polymer sleeve disposed over the inner shaft, the polymer sleeve comprising a first end attached to the distal end of the outer shaft and a second end attached to an attachment point on the inner shaft;
wherein the polymer sleeve is actuatable between an unlocked position in which the outer shaft may translate with respect to the inner shaft and a locked position in which the outer shaft is locked to the inner shaft and cannot translate.
9. The medical device of claim 8 , wherein the polymer sleeve comprises an electro-active polymer.
10. The medical device of claim 9 , wherein the polymer sleeve is actuatable from the unlocked position to the locked position by applying an electric current to the electro-active polymer, causing the polymer sleeve to constrict down onto the inner shaft.
11. The medical device of claim 10 , wherein the electric current is transmitted to the electro-active polymer via the outer shaft.
12. The medical device of claim 2 , wherein the outer shaft includes a micromachined hypotube.
13. The medical device of claim 12 , wherein the micromachined hypotube includes a plurality of flexibility-inducing slots disposed along the micromachined hypotube, the slots extending radially about the micromachined hypotube.
14. The medical device of claim 13 , wherein the plurality of flexibility-inducing slots includes a first plurality of slots having a first slot density disposed within the proximal region of the micromachined hypotube and a second plurality of slots having a second slot density disposed within the distal region of the micromachined hypotube, and the second slot density is greater than the first slot density.
15. The medical device of claim 14 , wherein the first slot density changes to the second slot density in a step-wise fashion.
16. The medical device of claim 14 , wherein the first slot density changes to the second slot density in a continuous fashion.
17. The medical device of claim 12 , wherein the micromachined hypotube includes a first plurality of slots disposed within a first portion, the slots extending at least partially circumferentially around the micromachined hypotube, and a second plurality of slots disposed within a second portion, the slots extending at least partially circumferentially around the micromachined hypotube;
wherein the second plurality of slots include adjacent slots having a spacing therebetween that is less than a spacing between adjacent slots within the first plurality of slots.
18. The medical device of claim 17 , wherein each of the first plurality of slots extend circumferentially about half way around the micromachined hypotube.
19. The medical device of claim 17 , wherein adjacent slots within the first plurality of slots are radially offset from each other.
20. The medical device of claim 17 , wherein each of the second plurality of slots extend circumferentially about half way around the micromachined hypotube.
21. The medical device of claim 17 , wherein adjacent slots within the second plurality of slots are radially offset from each other.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/658,309 US20130072904A1 (en) | 2005-12-12 | 2012-10-23 | Micromachined medical devices |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/301,195 US8292827B2 (en) | 2005-12-12 | 2005-12-12 | Micromachined medical devices |
US13/658,309 US20130072904A1 (en) | 2005-12-12 | 2012-10-23 | Micromachined medical devices |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/301,195 Continuation US8292827B2 (en) | 2005-12-12 | 2005-12-12 | Micromachined medical devices |
Publications (1)
Publication Number | Publication Date |
---|---|
US20130072904A1 true US20130072904A1 (en) | 2013-03-21 |
Family
ID=38140379
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/301,195 Active 2029-02-09 US8292827B2 (en) | 2005-12-12 | 2005-12-12 | Micromachined medical devices |
US13/658,309 Abandoned US20130072904A1 (en) | 2005-12-12 | 2012-10-23 | Micromachined medical devices |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/301,195 Active 2029-02-09 US8292827B2 (en) | 2005-12-12 | 2005-12-12 | Micromachined medical devices |
Country Status (6)
Country | Link |
---|---|
US (2) | US8292827B2 (en) |
EP (1) | EP1968678B1 (en) |
JP (1) | JP5202328B2 (en) |
AT (1) | ATE518559T1 (en) |
CA (1) | CA2633048C (en) |
WO (1) | WO2007070235A2 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9918705B2 (en) | 2016-07-07 | 2018-03-20 | Brian Giles | Medical devices with distal control |
WO2019118792A1 (en) * | 2017-12-15 | 2019-06-20 | Boston Scientific Scimed, Inc. | Medical device for accessing and/or treating the neural vasculature |
US10327933B2 (en) | 2015-04-28 | 2019-06-25 | Cook Medical Technologies Llc | Medical cannulae, delivery systems and methods |
US10391274B2 (en) | 2016-07-07 | 2019-08-27 | Brian Giles | Medical device with distal torque control |
US10555756B2 (en) | 2016-06-27 | 2020-02-11 | Cook Medical Technologies Llc | Medical devices having coaxial cannulae |
US10653861B2 (en) | 2014-05-02 | 2020-05-19 | Intellimedical Technologies Pty. Ltd. | Elongate steerable devices for insertion into a subjects body |
US10675057B2 (en) | 2015-04-28 | 2020-06-09 | Cook Medical Technologies Llc | Variable stiffness cannulae and associated delivery systems and methods |
WO2020154314A1 (en) * | 2019-01-21 | 2020-07-30 | Transit Scientific, LLC | Hypotube catheters |
US10751514B2 (en) | 2016-12-09 | 2020-08-25 | Teleflex Life Sciences Limited | Guide extension catheter |
US10946177B2 (en) | 2018-12-19 | 2021-03-16 | Teleflex Life Sciences Limited | Guide extension catheter |
US10953197B2 (en) | 2019-01-07 | 2021-03-23 | Teleflex Life Sciences Limited | Guide extension catheter |
US10974028B2 (en) | 2015-05-26 | 2021-04-13 | Teleflex Life Sciences Limited | Guidewire fixation |
US11524142B2 (en) | 2018-11-27 | 2022-12-13 | Teleflex Life Sciences Limited | Guide extension catheter |
Families Citing this family (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7815600B2 (en) | 2002-03-22 | 2010-10-19 | Cordis Corporation | Rapid-exchange balloon catheter shaft and method |
US8292827B2 (en) | 2005-12-12 | 2012-10-23 | Boston Scientific Scimed, Inc. | Micromachined medical devices |
US20070208405A1 (en) * | 2006-03-06 | 2007-09-06 | Boston Scientific Scimed, Inc. | Stent delivery catheter |
US9232959B2 (en) | 2007-01-02 | 2016-01-12 | Aquabeam, Llc | Multi fluid tissue resection methods and devices |
JP2009000389A (en) * | 2007-06-22 | 2009-01-08 | Kaneka Corp | Flexible slit marker and catheter having the same |
US8066703B2 (en) * | 2007-10-08 | 2011-11-29 | Boston Scientific Scimed, Inc. | Sphincterotome with improved orientation |
US8460213B2 (en) * | 2008-01-03 | 2013-06-11 | Boston Scientific Scimed, Inc. | Cut tubular members for a medical device and methods for making and using the same |
EP2259742B1 (en) | 2008-03-06 | 2020-01-01 | AquaBeam LLC | Tissue ablation and cautery with optical energy carried in fluid stream |
US20100069882A1 (en) * | 2008-09-18 | 2010-03-18 | Boston Scientific Scimed, Inc. | Medical device with preferential bending |
US10363389B2 (en) * | 2009-04-03 | 2019-07-30 | Scientia Vascular, Llc | Micro-fabricated guidewire devices having varying diameters |
EP2370237B1 (en) | 2008-12-08 | 2015-12-02 | Jeff Christian | Micro-cutting machine for forming cuts in products |
US11406791B2 (en) | 2009-04-03 | 2022-08-09 | Scientia Vascular, Inc. | Micro-fabricated guidewire devices having varying diameters |
EP2387433A4 (en) * | 2009-01-15 | 2012-07-18 | Cathrx Ltd | Steerable stylet |
US8057430B2 (en) | 2009-02-20 | 2011-11-15 | Boston Scientific Scimed, Inc. | Catheter with skived tubular member |
EP2398547A1 (en) * | 2009-02-20 | 2011-12-28 | Boston Scientific Scimed, Inc. | Torqueable balloon catheter |
WO2010096708A1 (en) | 2009-02-20 | 2010-08-26 | Boston Scientific Scimed, Inc. | Balloon catheter for placemnt of a stent in a bifurcated vessel |
US9616195B2 (en) * | 2009-04-03 | 2017-04-11 | Scientia Vascular, Llc | Micro-fabricated catheter devices having varying diameters |
US9067333B2 (en) * | 2009-04-03 | 2015-06-30 | Scientia Vascular, Llc | Micro-fabricated guidewire devices having elastomeric fill compositions |
US9950137B2 (en) * | 2009-04-03 | 2018-04-24 | Scientia Vascular, Llc | Micro-fabricated guidewire devices formed with hybrid materials |
US9067332B2 (en) * | 2009-04-03 | 2015-06-30 | Scientia Vascular, Llc | Micro-fabricated catheter devices formed with hybrid materials |
US9254123B2 (en) | 2009-04-29 | 2016-02-09 | Hansen Medical, Inc. | Flexible and steerable elongate instruments with shape control and support elements |
US10743780B2 (en) * | 2010-05-25 | 2020-08-18 | Miracor Medical Sa | Catheter system and method for occluding a body vessel |
US8827948B2 (en) | 2010-09-17 | 2014-09-09 | Hansen Medical, Inc. | Steerable catheters |
EP2673034A1 (en) * | 2011-02-09 | 2013-12-18 | Boston Scientific Scimed, Inc. | Balloon catheter |
US8821478B2 (en) * | 2011-03-04 | 2014-09-02 | Boston Scientific Scimed, Inc. | Catheter with variable stiffness |
EP2683433B1 (en) * | 2011-03-07 | 2020-04-29 | Stryker Corporation | Balloon catheter and support shaft for same |
US9138166B2 (en) | 2011-07-29 | 2015-09-22 | Hansen Medical, Inc. | Apparatus and methods for fiber integration and registration |
EP2768568B1 (en) | 2011-10-18 | 2020-05-06 | Boston Scientific Scimed, Inc. | Integrated crossing balloon catheter |
US8911398B2 (en) * | 2011-11-04 | 2014-12-16 | Boston Scientific Scimed, Inc. | Catheter including a bare metal hypotube |
US9504604B2 (en) | 2011-12-16 | 2016-11-29 | Auris Surgical Robotics, Inc. | Lithotripsy eye treatment |
CN104203078B (en) | 2012-02-29 | 2018-04-20 | 普罗赛普特生物机器人公司 | The cutting tissue of automated image guiding and processing |
US10383765B2 (en) | 2012-04-24 | 2019-08-20 | Auris Health, Inc. | Apparatus and method for a global coordinate system for use in robotic surgery |
US8684953B2 (en) * | 2012-05-13 | 2014-04-01 | Ozca Engineering Solutions Ltd. | Steering tool |
DE102012010687B4 (en) | 2012-05-30 | 2021-08-19 | ADMEDES GmbH | A method for producing a body implant, an assembly comprising a guide wire and a body implant, and a medical instrument |
US9066828B2 (en) | 2012-06-15 | 2015-06-30 | Trivascular, Inc. | Endovascular delivery system with flexible and torqueable hypotube |
US9332998B2 (en) | 2012-08-13 | 2016-05-10 | Covidien Lp | Apparatus and methods for clot disruption and evacuation |
US9332999B2 (en) | 2012-08-13 | 2016-05-10 | Covidien Lp | Apparatus and methods for clot disruption and evacuation |
CN104884115B (en) | 2012-12-31 | 2018-12-21 | 明讯科技有限公司 | Facilitate radiopaque seal wire of conduit alignment |
EP3527250B8 (en) | 2012-12-31 | 2020-11-04 | Clearstream Technologies Limited | Radiopaque balloon catheter and guidewire to facilitate alignment |
US10231867B2 (en) | 2013-01-18 | 2019-03-19 | Auris Health, Inc. | Method, apparatus and system for a water jet |
CN103961785A (en) * | 2013-01-31 | 2014-08-06 | 朝日英达科株式会社 | Slitted pipe and guide wire using the same |
JP2015066163A (en) * | 2013-09-30 | 2015-04-13 | 朝日インテック株式会社 | Slit pipe and guide wire using slit pipe |
US10149720B2 (en) * | 2013-03-08 | 2018-12-11 | Auris Health, Inc. | Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment |
US10080576B2 (en) * | 2013-03-08 | 2018-09-25 | Auris Health, Inc. | Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment |
US9867635B2 (en) | 2013-03-08 | 2018-01-16 | Auris Surgical Robotics, Inc. | Method, apparatus and system for a water jet |
US10376672B2 (en) | 2013-03-15 | 2019-08-13 | Auris Health, Inc. | Catheter insertion system and method of fabrication |
US10744035B2 (en) | 2013-06-11 | 2020-08-18 | Auris Health, Inc. | Methods for robotic assisted cataract surgery |
US10426661B2 (en) | 2013-08-13 | 2019-10-01 | Auris Health, Inc. | Method and apparatus for laser assisted cataract surgery |
US9763741B2 (en) | 2013-10-24 | 2017-09-19 | Auris Surgical Robotics, Inc. | System for robotic-assisted endolumenal surgery and related methods |
US9737373B2 (en) | 2013-10-24 | 2017-08-22 | Auris Surgical Robotics, Inc. | Instrument device manipulator and surgical drape |
US10792464B2 (en) | 2014-07-01 | 2020-10-06 | Auris Health, Inc. | Tool and method for using surgical endoscope with spiral lumens |
US9744335B2 (en) | 2014-07-01 | 2017-08-29 | Auris Surgical Robotics, Inc. | Apparatuses and methods for monitoring tendons of steerable catheters |
US9788910B2 (en) | 2014-07-01 | 2017-10-17 | Auris Surgical Robotics, Inc. | Instrument-mounted tension sensing mechanism for robotically-driven medical instruments |
US9561083B2 (en) | 2014-07-01 | 2017-02-07 | Auris Surgical Robotics, Inc. | Articulating flexible endoscopic tool with roll capabilities |
USD743007S1 (en) * | 2014-12-01 | 2015-11-10 | Asahi Intecc Co., Ltd. | Slitted pipe |
US11819636B2 (en) | 2015-03-30 | 2023-11-21 | Auris Health, Inc. | Endoscope pull wire electrical circuit |
KR102569960B1 (en) | 2015-09-09 | 2023-08-24 | 아우리스 헬스, 인크. | Instrument device manipulator for a surgical robotics system |
US10799672B2 (en) * | 2015-10-16 | 2020-10-13 | Covidien Lp | Catheter body structural support member including a polymer hypotube |
US10252024B2 (en) | 2016-04-05 | 2019-04-09 | Stryker Corporation | Medical devices and methods of manufacturing same |
US11207502B2 (en) * | 2016-07-18 | 2021-12-28 | Scientia Vascular, Llc | Guidewire devices having shapeable tips and bypass cuts |
US11052228B2 (en) | 2016-07-18 | 2021-07-06 | Scientia Vascular, Llc | Guidewire devices having shapeable tips and bypass cuts |
CN109789017B (en) * | 2016-08-19 | 2022-05-31 | 爱德华兹生命科学公司 | Steerable delivery system for replacing a mitral valve and methods of use |
US10463439B2 (en) | 2016-08-26 | 2019-11-05 | Auris Health, Inc. | Steerable catheter with shaft load distributions |
US10821268B2 (en) | 2016-09-14 | 2020-11-03 | Scientia Vascular, Llc | Integrated coil vascular devices |
EP4252998A3 (en) | 2016-12-08 | 2024-01-31 | Abiomed, Inc. | Overmold technique for peel-away introducer design |
US11452541B2 (en) | 2016-12-22 | 2022-09-27 | Scientia Vascular, Inc. | Intravascular device having a selectively deflectable tip |
US20200093472A1 (en) * | 2017-03-24 | 2020-03-26 | Robert J Cottone | Systems and methods for tissue displacement |
CN110769736B (en) | 2017-05-17 | 2023-01-13 | 奥瑞斯健康公司 | Replaceable working channel |
US11369351B2 (en) | 2017-05-26 | 2022-06-28 | Scientia Vascular, Inc. | Micro-fabricated medical device having a non-helical cut arrangement |
CA3084628A1 (en) | 2017-12-14 | 2019-06-20 | Meacor Sal | Helical anchor driving system |
WO2019148215A1 (en) * | 2018-01-29 | 2019-08-01 | Transit Scientific, LLC | Elongated medical instruments with flexibility‑enhancing features |
US10456556B2 (en) * | 2018-02-19 | 2019-10-29 | Bendit Technologies Ltd. | Steering tool with enhanced flexibility and trackability |
US11305095B2 (en) | 2018-02-22 | 2022-04-19 | Scientia Vascular, Llc | Microfabricated catheter having an intermediate preferred bending section |
JP7305668B2 (en) | 2018-03-28 | 2023-07-10 | オーリス ヘルス インコーポレイテッド | Medical device with variable bending stiffness profile |
KR20200071749A (en) * | 2018-05-09 | 2020-06-19 | 아사히 인텍크 가부시키가이샤 | Medical tube |
KR20210020911A (en) | 2018-05-16 | 2021-02-24 | 아비오메드, 인크. | Detachable sheath assembly |
US10898276B2 (en) | 2018-08-07 | 2021-01-26 | Auris Health, Inc. | Combining strain-based shape sensing with catheter control |
US11660420B2 (en) | 2018-09-17 | 2023-05-30 | Seigla Medical, Inc. | Catheters and related devices and methods of manufacture |
WO2020068853A2 (en) | 2018-09-26 | 2020-04-02 | Auris Health, Inc. | Articulating medical instruments |
US11617627B2 (en) | 2019-03-29 | 2023-04-04 | Auris Health, Inc. | Systems and methods for optical strain sensing in medical instruments |
KR20220050151A (en) | 2019-08-15 | 2022-04-22 | 아우리스 헬스, 인코포레이티드 | Medical device having multiple bend sections |
US11478609B2 (en) * | 2019-09-26 | 2022-10-25 | Biosense Webster (Israel) Ltd. | Bendable guidewire |
US11642178B2 (en) | 2020-02-07 | 2023-05-09 | Centerline Biomedical, Inc. | Guidewire |
CN115175722A (en) * | 2020-03-11 | 2022-10-11 | 史赛克公司 | Slotted medical instrument with filler |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5730726A (en) * | 1996-03-04 | 1998-03-24 | Klingenstein; Ralph James | Apparatus and method for removing fecal impaction |
US5928260A (en) * | 1997-07-10 | 1999-07-27 | Scimed Life Systems, Inc. | Removable occlusion system for aneurysm neck |
Family Cites Families (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4547193A (en) | 1984-04-05 | 1985-10-15 | Angiomedics Incorporated | Catheter having embedded multi-apertured film |
US4580551A (en) | 1984-11-02 | 1986-04-08 | Warner-Lambert Technologies, Inc. | Flexible plastic tube for endoscopes and the like |
US4795439A (en) | 1986-06-06 | 1989-01-03 | Edward Weck Incorporated | Spiral multi-lumen catheter |
US4753238A (en) | 1987-01-06 | 1988-06-28 | Advanced Cardiovascular Systems, Inc. | Proximal manifold and adapter |
US4998923A (en) | 1988-08-11 | 1991-03-12 | Advanced Cardiovascular Systems, Inc. | Steerable dilatation catheter |
US5507751A (en) | 1988-11-09 | 1996-04-16 | Cook Pacemaker Corporation | Locally flexible dilator sheath |
US5095915A (en) | 1990-03-19 | 1992-03-17 | Target Therapeutics | Guidewire with flexible distal tip |
US5238004A (en) | 1990-04-10 | 1993-08-24 | Boston Scientific Corporation | High elongation linear elastic guidewire |
US5106455A (en) | 1991-01-28 | 1992-04-21 | Sarcos Group | Method and apparatus for fabrication of micro-structures using non-planar, exposure beam lithography |
US5329923A (en) | 1991-02-15 | 1994-07-19 | Lundquist Ingemar H | Torquable catheter |
AU660444B2 (en) | 1991-02-15 | 1995-06-29 | Ingemar H. Lundquist | Torquable catheter and method |
US5228441A (en) | 1991-02-15 | 1993-07-20 | Lundquist Ingemar H | Torquable catheter and method |
US5315996A (en) | 1991-02-15 | 1994-05-31 | Lundquist Ingemar H | Torquable catheter and method |
US5741429A (en) | 1991-09-05 | 1998-04-21 | Cardia Catheter Company | Flexible tubular device for use in medical applications |
CA2117088A1 (en) | 1991-09-05 | 1993-03-18 | David R. Holmes | Flexible tubular device for use in medical applications |
US5328472A (en) | 1992-07-27 | 1994-07-12 | Medtronic, Inc. | Catheter with flexible side port entry |
US5437288A (en) | 1992-09-04 | 1995-08-01 | Mayo Foundation For Medical Education And Research | Flexible catheter guidewire |
US5334145A (en) | 1992-09-16 | 1994-08-02 | Lundquist Ingemar H | Torquable catheter |
US5372144A (en) | 1992-12-01 | 1994-12-13 | Scimed Life Systems, Inc. | Navigability improved guidewire construction and method of using same |
EP0608853B1 (en) | 1993-01-26 | 2003-04-02 | Terumo Kabushiki Kaisha | Vascular dilatation instrument and catheter |
JP3345147B2 (en) | 1993-01-26 | 2002-11-18 | テルモ株式会社 | Vasodilators and catheters |
US6576008B2 (en) | 1993-02-19 | 2003-06-10 | Scimed Life Systems, Inc. | Methods and device for inserting and withdrawing a two piece stent across a constricting anatomic structure |
US5772609A (en) | 1993-05-11 | 1998-06-30 | Target Therapeutics, Inc. | Guidewire with variable flexibility due to polymeric coatings |
US5989280A (en) | 1993-10-22 | 1999-11-23 | Scimed Lifesystems, Inc | Stent delivery apparatus and method |
BR9507017A (en) * | 1994-03-10 | 1997-09-09 | Schneider Usa Inc | Body catheter with variable stiffness |
US5902290A (en) | 1994-03-14 | 1999-05-11 | Advanced Cardiovascular Systems, Inc. | Catheter providing intraluminal access |
US6139510A (en) | 1994-05-11 | 2000-10-31 | Target Therapeutics Inc. | Super elastic alloy guidewire |
US5569197A (en) | 1994-12-21 | 1996-10-29 | Schneider (Usa) Inc | Drug delivery guidewire |
US5797856A (en) | 1995-01-05 | 1998-08-25 | Cardiometrics, Inc. | Intravascular guide wire and method |
JPH08257128A (en) * | 1995-03-24 | 1996-10-08 | Piolax Inc | Medical tube |
US5788707A (en) | 1995-06-07 | 1998-08-04 | Scimed Life Systems, Inc. | Pull back sleeve system with compression resistant inner shaft |
US6287315B1 (en) | 1995-10-30 | 2001-09-11 | World Medical Manufacturing Corporation | Apparatus for delivering an endoluminal prosthesis |
US6428489B1 (en) | 1995-12-07 | 2002-08-06 | Precision Vascular Systems, Inc. | Guidewire system |
CA2192045A1 (en) | 1995-12-07 | 1997-06-08 | Stephen C. Jacobsen | Catheter guide wire apparatus |
US5833632A (en) | 1995-12-07 | 1998-11-10 | Sarcos, Inc. | Hollow guide wire apparatus catheters |
US20030069522A1 (en) | 1995-12-07 | 2003-04-10 | Jacobsen Stephen J. | Slotted medical device |
US6004279A (en) | 1996-01-16 | 1999-12-21 | Boston Scientific Corporation | Medical guidewire |
US5695506A (en) | 1996-02-06 | 1997-12-09 | Devices For Vascular Intervention | Catheter device with a flexible housing |
US6533805B1 (en) | 1996-04-01 | 2003-03-18 | General Surgical Innovations, Inc. | Prosthesis and method for deployment within a body lumen |
US6629981B2 (en) | 2000-07-06 | 2003-10-07 | Endocare, Inc. | Stent delivery system |
US6440088B1 (en) | 1996-05-24 | 2002-08-27 | Precision Vascular Systems, Inc. | Hybrid catheter guide wire apparatus and method |
US6017319A (en) | 1996-05-24 | 2000-01-25 | Precision Vascular Systems, Inc. | Hybrid tubular guide wire for catheters |
US6077295A (en) | 1996-07-15 | 2000-06-20 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent delivery system |
US6007543A (en) | 1996-08-23 | 1999-12-28 | Scimed Life Systems, Inc. | Stent delivery system with stent securement means |
US6391032B2 (en) | 1996-08-23 | 2002-05-21 | Scimed Life Systems, Inc. | Stent delivery system having stent securement means |
US6077273A (en) | 1996-08-23 | 2000-06-20 | Scimed Life Systems, Inc. | Catheter support for stent delivery |
US5968069A (en) | 1996-08-23 | 1999-10-19 | Scimed Life Systems, Inc. | Stent delivery system having stent securement apparatus |
US6123712A (en) | 1996-08-23 | 2000-09-26 | Scimed Life Systems, Inc. | Balloon catheter with stent securement means |
US6014919A (en) | 1996-09-16 | 2000-01-18 | Precision Vascular Systems, Inc. | Method and apparatus for forming cuts in catheters, guidewires, and the like |
US5772669A (en) | 1996-09-27 | 1998-06-30 | Scimed Life Systems, Inc. | Stent deployment catheter with retractable sheath |
US6001068A (en) | 1996-10-22 | 1999-12-14 | Terumo Kabushiki Kaisha | Guide wire having tubular connector with helical slits |
DE19721703A1 (en) | 1997-05-23 | 1998-11-26 | Angiomed Ag | Catheter system with high kink resistance |
KR19990072499A (en) | 1998-02-19 | 1999-09-27 | 리페르트 존 | Catheter guidewire apparatus with location specific flexibility |
US6174327B1 (en) | 1998-02-27 | 2001-01-16 | Scimed Life Systems, Inc. | Stent deployment apparatus and method |
EP0941713B1 (en) | 1998-03-04 | 2004-11-03 | Schneider (Europe) GmbH | Device to insert an endoprosthesis into a catheter shaft |
AU3342399A (en) | 1998-03-31 | 1999-10-18 | Salviac Limited | A delivery catheter |
IE980241A1 (en) | 1998-04-02 | 1999-10-20 | Salviac Ltd | Delivery catheter with split sheath |
US6004310A (en) | 1998-06-17 | 1999-12-21 | Target Therapeutics, Inc. | Multilumen catheter shaft with reinforcement |
US6048339A (en) | 1998-06-29 | 2000-04-11 | Endius Incorporated | Flexible surgical instruments with suction |
US6093194A (en) | 1998-09-14 | 2000-07-25 | Endocare, Inc. | Insertion device for stents and methods for use |
WO2000027462A1 (en) | 1998-11-06 | 2000-05-18 | The Furukawa Electric Co., Ltd. | NiTi-TYPE MEDICAL GUIDE WIRE AND METHOD OF PRODUCING THE SAME |
US6102932A (en) | 1998-12-15 | 2000-08-15 | Micrus Corporation | Intravascular device push wire delivery system |
US6254609B1 (en) | 1999-01-11 | 2001-07-03 | Scimed Life Systems, Inc. | Self-expanding stent delivery system with two sheaths |
CA2336416A1 (en) | 1999-04-30 | 2000-11-09 | Gono Usami | Catheter and guide wire |
US6241758B1 (en) | 1999-05-28 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent delivery system and method of use |
US6168617B1 (en) | 1999-06-14 | 2001-01-02 | Scimed Life Systems, Inc. | Stent delivery system |
US6398802B1 (en) | 1999-06-21 | 2002-06-04 | Scimed Life Systems, Inc. | Low profile delivery system for stent and graft deployment |
US6287291B1 (en) | 1999-11-09 | 2001-09-11 | Advanced Cardiovascular Systems, Inc. | Protective sheath for catheters |
US6702802B1 (en) | 1999-11-10 | 2004-03-09 | Endovascular Technologies, Inc. | Catheters with improved transition |
US6579246B2 (en) | 1999-12-22 | 2003-06-17 | Sarcos, Lc | Coronary guidewire system |
US6602280B2 (en) | 2000-02-02 | 2003-08-05 | Trivascular, Inc. | Delivery system and method for expandable intracorporeal device |
US6607555B2 (en) | 2000-02-15 | 2003-08-19 | Eva Corporation | Delivery catheter assembly and method of securing a surgical component to a vessel during a surgical procedure |
US6773446B1 (en) | 2000-08-02 | 2004-08-10 | Cordis Corporation | Delivery apparatus for a self-expanding stent |
US6562064B1 (en) | 2000-10-27 | 2003-05-13 | Vascular Architects, Inc. | Placement catheter assembly |
US6428566B1 (en) | 2000-10-31 | 2002-08-06 | Advanced Cardiovascular Systems, Inc. | Flexible hoop and link sheath for a stent delivery system |
US6436090B1 (en) | 2000-12-21 | 2002-08-20 | Advanced Cardiovascular Systems, Inc. | Multi lumen catheter shaft |
US6592568B2 (en) | 2001-01-11 | 2003-07-15 | Scimed Life Systems, Inc. | Balloon assembly for stent delivery catheter |
US6623491B2 (en) | 2001-01-18 | 2003-09-23 | Ev3 Peripheral, Inc. | Stent delivery system with spacer member |
US6699274B2 (en) | 2001-01-22 | 2004-03-02 | Scimed Life Systems, Inc. | Stent delivery system and method of manufacturing same |
US6743210B2 (en) | 2001-02-15 | 2004-06-01 | Scimed Life Systems, Inc. | Stent delivery catheter positioning device |
US6592549B2 (en) | 2001-03-14 | 2003-07-15 | Scimed Life Systems, Inc. | Rapid exchange stent delivery system and associated components |
US6660031B2 (en) | 2001-04-11 | 2003-12-09 | Scimed Life Systems, Inc. | Multi-length delivery system |
ATE347393T1 (en) | 2001-07-05 | 2006-12-15 | Precision Vascular Systems Inc | MEDICAL DEVICE HAVING A TORQUE-TRANSMITTING SOFT END PIECE AND METHOD FOR SHAPING IT |
US6726714B2 (en) | 2001-08-09 | 2004-04-27 | Scimed Life Systems, Inc. | Stent delivery system |
US6918882B2 (en) | 2001-10-05 | 2005-07-19 | Scimed Life Systems, Inc. | Guidewire with stiffness blending connection |
US6652508B2 (en) | 2001-11-09 | 2003-11-25 | Scimed Life Systems, Inc. | Intravascular microcatheter having hypotube proximal shaft with transition |
JP2003164528A (en) * | 2001-11-29 | 2003-06-10 | Nippon Sherwood Medical Industries Ltd | Balloon catheter |
JP2003175110A (en) | 2001-12-07 | 2003-06-24 | Kanegafuchi Chem Ind Co Ltd | Balloon catheter and method for manufacturing the same |
US7294124B2 (en) | 2001-12-28 | 2007-11-13 | Boston Scientific Scimed, Inc. | Hypotube with improved strain relief |
JP4602080B2 (en) | 2002-07-25 | 2010-12-22 | ボストン サイエンティフィック リミテッド | Medical devices that travel through the human body structure |
US20040167437A1 (en) | 2003-02-26 | 2004-08-26 | Sharrow James S. | Articulating intracorporal medical device |
US20040167441A1 (en) | 2003-02-26 | 2004-08-26 | Reynolds Brian R. | Composite medical device |
US7142903B2 (en) | 2003-03-12 | 2006-11-28 | Biosense Webster, Inc. | Catheter with contractable mapping assembly |
US7276062B2 (en) | 2003-03-12 | 2007-10-02 | Biosence Webster, Inc. | Deflectable catheter with hinge |
US7001369B2 (en) | 2003-03-27 | 2006-02-21 | Scimed Life Systems, Inc. | Medical device |
US7785273B2 (en) | 2003-09-22 | 2010-08-31 | Boston Scientific Scimed, Inc. | Guidewire with reinforcing member |
US7744619B2 (en) | 2004-02-24 | 2010-06-29 | Boston Scientific Scimed, Inc. | Rotatable catheter assembly |
US20050209582A1 (en) * | 2004-03-22 | 2005-09-22 | Medtronic Vascular, Inc. | Multi-lumen catheter system |
US20050234499A1 (en) | 2004-04-19 | 2005-10-20 | Scimed Life Systems, Inc. | Multi-lumen balloon catheter including manifold |
US20070083132A1 (en) | 2005-10-11 | 2007-04-12 | Sharrow James S | Medical device coil |
US8292827B2 (en) | 2005-12-12 | 2012-10-23 | Boston Scientific Scimed, Inc. | Micromachined medical devices |
-
2005
- 2005-12-12 US US11/301,195 patent/US8292827B2/en active Active
-
2006
- 2006-11-22 WO PCT/US2006/045284 patent/WO2007070235A2/en active Application Filing
- 2006-11-22 CA CA2633048A patent/CA2633048C/en not_active Expired - Fee Related
- 2006-11-22 AT AT06838313T patent/ATE518559T1/en not_active IP Right Cessation
- 2006-11-22 JP JP2008545617A patent/JP5202328B2/en active Active
- 2006-11-22 EP EP06838313A patent/EP1968678B1/en active Active
-
2012
- 2012-10-23 US US13/658,309 patent/US20130072904A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5730726A (en) * | 1996-03-04 | 1998-03-24 | Klingenstein; Ralph James | Apparatus and method for removing fecal impaction |
US5928260A (en) * | 1997-07-10 | 1999-07-27 | Scimed Life Systems, Inc. | Removable occlusion system for aneurysm neck |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10653861B2 (en) | 2014-05-02 | 2020-05-19 | Intellimedical Technologies Pty. Ltd. | Elongate steerable devices for insertion into a subjects body |
US11523924B2 (en) | 2015-04-28 | 2022-12-13 | Cook Medical Technologies Llc | Medical cannulae, delivery systems and methods |
US10327933B2 (en) | 2015-04-28 | 2019-06-25 | Cook Medical Technologies Llc | Medical cannulae, delivery systems and methods |
US10675057B2 (en) | 2015-04-28 | 2020-06-09 | Cook Medical Technologies Llc | Variable stiffness cannulae and associated delivery systems and methods |
US10974028B2 (en) | 2015-05-26 | 2021-04-13 | Teleflex Life Sciences Limited | Guidewire fixation |
US10555756B2 (en) | 2016-06-27 | 2020-02-11 | Cook Medical Technologies Llc | Medical devices having coaxial cannulae |
US9918705B2 (en) | 2016-07-07 | 2018-03-20 | Brian Giles | Medical devices with distal control |
US10786230B2 (en) | 2016-07-07 | 2020-09-29 | Micronovus, Llc | Medical devices with distal control |
US10391274B2 (en) | 2016-07-07 | 2019-08-27 | Brian Giles | Medical device with distal torque control |
US11141141B2 (en) | 2016-07-07 | 2021-10-12 | Micronovus, Llc | Medical devices with distal control |
US11717641B2 (en) | 2016-07-07 | 2023-08-08 | Micronovus, Llc | Medical device with distal torque control |
US10751514B2 (en) | 2016-12-09 | 2020-08-25 | Teleflex Life Sciences Limited | Guide extension catheter |
US11712544B2 (en) | 2016-12-09 | 2023-08-01 | Teleflex Life Sciences Limited | Guide extension catheter |
WO2019118792A1 (en) * | 2017-12-15 | 2019-06-20 | Boston Scientific Scimed, Inc. | Medical device for accessing and/or treating the neural vasculature |
US11524142B2 (en) | 2018-11-27 | 2022-12-13 | Teleflex Life Sciences Limited | Guide extension catheter |
US10946177B2 (en) | 2018-12-19 | 2021-03-16 | Teleflex Life Sciences Limited | Guide extension catheter |
US10953197B2 (en) | 2019-01-07 | 2021-03-23 | Teleflex Life Sciences Limited | Guide extension catheter |
WO2020154314A1 (en) * | 2019-01-21 | 2020-07-30 | Transit Scientific, LLC | Hypotube catheters |
Also Published As
Publication number | Publication date |
---|---|
JP5202328B2 (en) | 2013-06-05 |
ATE518559T1 (en) | 2011-08-15 |
EP1968678B1 (en) | 2011-08-03 |
EP1968678A2 (en) | 2008-09-17 |
WO2007070235A2 (en) | 2007-06-21 |
US20070135763A1 (en) | 2007-06-14 |
JP2009519103A (en) | 2009-05-14 |
US8292827B2 (en) | 2012-10-23 |
CA2633048C (en) | 2014-08-12 |
WO2007070235A3 (en) | 2008-05-02 |
CA2633048A1 (en) | 2007-06-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8292827B2 (en) | Micromachined medical devices | |
US10315018B2 (en) | Catheter shaft designs | |
EP2185232B1 (en) | Microfabricated catheter with improved bonding structure | |
US8535243B2 (en) | Medical devices and tapered tubular members for use in medical devices | |
US9227037B2 (en) | Cut tubular members for a medical device and methods for making and using the same | |
US7914467B2 (en) | Tubular member having tapered transition for use in a medical device | |
US9375234B2 (en) | Medical device including structure for crossing an occlusion in a vessel | |
US8585643B2 (en) | Balloon catheter and method of manufacture | |
US8137293B2 (en) | Guidewires including a porous nickel-titanium alloy | |
US8376961B2 (en) | Micromachined composite guidewire structure with anisotropic bending properties | |
US20120209176A1 (en) | Balloon catheter | |
US8795202B2 (en) | Guidewires and methods for making and using the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |