US20140100530A1 - Attachable uterine device with integrated and time release medicinal administering component and insertion tool for implanting such a device - Google Patents
Attachable uterine device with integrated and time release medicinal administering component and insertion tool for implanting such a device Download PDFInfo
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- US20140100530A1 US20140100530A1 US14/047,409 US201314047409A US2014100530A1 US 20140100530 A1 US20140100530 A1 US 20140100530A1 US 201314047409 A US201314047409 A US 201314047409A US 2014100530 A1 US2014100530 A1 US 2014100530A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/14—Female reproductive, genital organs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M25/04—Holding devices, e.g. on the body in the body, e.g. expansible
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Surgical Instruments (AREA)
Abstract
A medicinal delivery device adapted to being applied to a surface of an internal organ and exhibiting a three dimensional shaped body having an upper surface and at least one underside layer within which is entrained a medicinal application layer. Upon adhering the underside of the body to an exterior of the organ, medication is administered in a controlled and time release delivery fashion. A deformable upper portion of the body is provided in combination with at least one underside and suction inducing location. The medicinal and suction inducing locations further can include concentrically arranged layers. An aperture is located within an enclosed inner defined volume associated with the suction inducing location.
Description
- This Application claims the benefit of U.S. Provisional Application 61/710,079 filed on Oct. 5, 2012, the contents of which are incorporated herein in its entirety.
- The present invention is generally related to an area focused medicinal delivery system associated with human internal organs. More specifically, the present invention discloses an implantable device which is attached to the tissue or mucous membrane lining of a human organ, such as a female cervix, through a variety of means not limited to vacuum suction and/or mechanical fastening. The attachable device further includes a medicinal holding component which is configured for delivering, in controlled and time release fashion, an on-site medication incorporated within the component prior to attachment. This device is capable of delivering a medication to abnormal or diseased areas while protecting the normal tissues around that area from the toxic effect of the medicine.
- The prior art is documented with examples of medicinal delivery devices, such as which can be implanted in situ within a patient body cavity. Examples of such implantable drug delivery devices include each of Atanasoska et al., U.S. Pat. No. 8,538,515, Heruth et al. U.S. Pat. No. 8,216,177, Aston U.S. Pat. No. 5,773,019 and Benchetrit U.S. Pat. No. 6,878,137.
- An example of a uterine attachable and implantable device is depicted in Girard 2012/0071905 which teaches a biocompatible polyethylene teraphathalate (PET) material which is deliverable into the body cavity and which contains a tissue growth promoting attribute for reducing or stopping excessive bleeding. Another example of an implantable and sealable system for unidirectional delivery of therapeutic agents to tissues is depicted in U.S. Pat. No. 7,195,774 to Carvalho. The implantable device includes a tissue or organ surface contacting port or window for permitting diffusion of the agent, such as chemotherapeutics or bio-active agents.
- US 2012/0020877 to Raspagliesi teaches an intrauterine device for local release of drugs in the loco-regional treatment of tumors of the uterine cervix which includes an elongate stem positioned in the cervix canal. The stem consists of an inner hollow core and a coating containing a gradual-release drug. The stem is attached to a first upper end located element for blocking the stem inside the uterine cavity and a second lower end located element at the ectocervix location of the vagina.
- The present invention discloses a medicinal delivery device adapted to being applied to a surface of an internal organ and exhibiting a three dimensional shaped body having an upper surface and at least one underside layer within which is entrained a medicinal application layer and which, upon adhering the underside of the body to an exterior of the organ, providing for controlled and time release delivery of medication to the organ. A variation of the body may further include a deformable upper portion in combination with at least one underside and suction inducing location. The medicinal and suction inducing locations further can include concentrically arranged layers. An aperture is located within an enclosed inner defined volume associated with the suction inducing location.
- The body can also include a plurality of individual and suction inducing pads, each exhibiting octopus style suction cups. In an alternate application, a needle inserted through a soft self-sealing material incorporated within said body for creating internal suction. The medicinal delivery body may also exhibit an inner suction chamber interconnected with a plurality of individual outer and perimeter extending chambers. In another variant, a plurality of underside projecting prongs may be provided for attaching the body to the selected organ, and as an alternative to a suction or vacuum attachment configuration.
- A tool may also be provided for implanting the delivery device within the patient body cavity, such as again in attachment to the uterine wall or other organ. The tool may include an elongated body with forward actuating gripping fingers for locating and implanting the three dimensional shaped body of the delivery device.
- In one non-limiting configuration the three dimensional shaped body includes inwardly deflectable gripping portions accessible through recessed locations exhibited on a rear surface of the body. A trigger on the tool is provided for activating the gripping fingers. The tool exerts a vacuum retaining force on a flexible surface of the three dimensional shaped body. In a further variant, the tool can incorporate a light source for assisting in implantation of the three dimensional shaped body.
- Reference will now be made to the attached drawings, when read in combination with the following detailed description, wherein like reference numerals refer to like parts throughout the several views, and in which:
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FIG. 1 is an enlarged and environmental perspective of a human uterus to which the medicinal delivery device is secured at a surface location by a depressible and suction inducing middle component; -
FIG. 2 is a rotated underside of the medicinal delivery device ofFIG. 1 and which illustrates the concentrically arranged suction and medicinal incorporating components in contact with the surface of the organ; -
FIG. 3 is an illustration similar toFIG. 2 of an alternate underside configuration of a medicinal delivery device in which the suction generating areas exhibit a grooved profile; -
FIG. 4 is an upper side perspective similar toFIG. 1 of an alternate configuration of medicinal delivery device in which the single large suction pad is reconfigured as a plurality of smaller and individually suction generating pads; -
FIG. 5 is a rotated underside of the medicinal delivery device ofFIG. 4 and which illustrates the arrangement of the medicinal delivery surface surrounding the individually placed suction pads; -
FIG. 6 is an underside perspective of a species variation of the embodiment generally shown inFIG. 5 and in which the individual suction pads are reconfigured with inner hemispherical underside projections to assist in suction generation; -
FIG. 7 is an illustration of an environmental perspective of a cervix attachable medicinal delivery device according to a yet further variant and in which a central nipple aperture formed into a soft sealing material receives a tip of an inserted needle in order to create a retaining suction with the uterine surface exterior; -
FIG. 8 is a rotated underside of the medicinal delivery device ofFIG. 7 exhibiting a pattern generally identical to that depicted inFIG. 2 , and with the needle tip evident from an exteriorly inserting location for generating the desired retaining suction within the underside interior for locating and holding the device in place upon the uterine exterior wall; -
FIG. 9 is an environmental perspective of a medicinal delivery device according to a further variant attached to the uterine exterior and in which a central and inner suction inducing chamber is individually communicated to a plurality of outer and perimeter arranged vacuum chambers for generating the desired suction adhering effect; -
FIG. 10 is a rotated underside of the medicinal delivery device ofFIG. 9 and which further illustrates the individual and generally trapezoidal shaped profile associated with each surrounding and circumferential/perimeter defined vacuum chambers along with showing the communicating apertures associated with each outer chamber for communicating the suction effects of the central chamber to the individual outer chambers; -
FIG. 11 is a perspective view of a medicinal delivery device according to a further variant and in which the suction generating aspects are substituted by underside projecting prongs for engaging within the uterine wall; -
FIG. 12 is an underside perspective of the medicinal delivery device ofFIG. 11 and in which a substantially flattened and disc shaped internal layer, through which the individual prongs project, comprises the medication delivery component; -
FIGS. 13A-13C are representative illustrations of different sized medicinal delivery devices adapted for implantation according to the present inventions; -
FIG. 14 is a perspective illustration of an insertion tool for delivery and implanting a medicinal delivery device; -
FIG. 15 is a plan view of the tool ofFIG. 14 and depicting a handle supported trigger mechanism for manipulating a combination of perimeter clamping and suctioning aspects for supporting the medicinal delivery device upon the inserting end of the tool, such as during the tool end and device being located in situ within the patient for subsequent depositing of the medicinal delivery device; -
FIG. 16 is a successive view toFIG. 15 and depicting actuation of the trigger mechanism for releasing the medicinal delivery device; -
FIG. 17 is an enlarged, reduced length and longitudinal cutaway view of the tool ofFIG. 15 better depicting the structure for accomplishing both perimeter clamp and vacuum release of the medicinal delivery device; -
FIG. 18 is a front perspective view of an implantable medicinal delivery device according to a further embodiment exhibiting outer perimeter configured and movable gripping portions for engaging an in situ implantation location; -
FIG. 19 is a rotated rear perspective view of the delivery device shown inFIG. 18 and depicting a plurality of outer perimeter insertion tool locations which align and communicate with the forward extending gripping portions; -
FIG. 20 is a plan view of the medicinal delivery device ofFIG. 18 in use with a modified and inserting delivery tool in which a forward engaging configuration of the tool exhibited by multiple gripping fingers both aligns with and seats within the back surface located insertion tool locators associated with the delivery device in a first open position associated with the perimeter located device gripping portions; -
FIG. 21 is a succeeding view toFIG. 20 in which a trigger clamp configured at a stem extending location of the tool results in the inward actuation of the end disposed gripping fingers, as well as concurrent inward actuation of the controlled gripping portions for implanting the delivery device in situ within the patient; -
FIG. 22 is an enlarged delivery end and longitudinal cutaway view of the tool ofFIG. 20 and which better depicts the inter-actuating linkages for controlling the gripping fingers in engagement with the medicinal delivery device; and -
FIG. 23 is an illustration of a modified inserting end of an installation tool such as similar to that depicted inFIG. 20 and in which a high intensity light source is integrated at a narrow cross sectional and elevated location in order to facilitate correct location and delivery of the medicinal delivery device. - As previously described, the present invention discloses an implantable device which is attachable to the tissue or membrane lining of a human organ, such as a female cervix, through a variety of means not limited to vacuum suction and/or mechanical fastening. The implantable device, as further described in detail with reference to each of the successive embodiments, incorporates a medicinal holding component which is configured for delivering, in controlled and time release fashion, an on-site medication, such as an anti-cancer or other disease treating composition, incorporated within the component prior to implantation.
- As is known, the uterus (also commonly referred to as “womb”) is a major female hormone-responsive and reproductive sex organ possessed by most mammals including humans. In the human anatomy, one of the uterus parts, called the cervix, open into the vagina, while the other is connected to one or both fallopian tubes. As is further known, it is within the uterus that a fetus develops during gestation, this usually developing completely in placental mammals including humans.
- The uterus typically includes a plurality of layers, from inside to outside including each of the endometrium (inner lining of the uterine cavity), the myometrium (smooth muscle layer), the parametrium (loose connective tissue around the uterus), and perimetrium (peritoneum covering of the fundus and ventral and dorsal aspects of the uterus). For purposes of simplification in association with the subsequent detailed description of each of the medicinal delivery devices associated with the inventions, the multiple layers recited herein will be generally referred to as the “uterine wall”.
- Additional anatomical aspects of the uterus include the provision of ligaments, also terms endopelvic fascia, for holding it into position within the pelvis. Types of these ligaments further include such as the cardinal and pubo-cervical (sides of cervix), transverse, cervical and uterosacral (posterior cervix) ligaments. Additional to its normal sexual reproductive functions, the uterus is susceptible to various medical risks or conditions, these often resulting from the carrying of a fetus and including such as various pathological changes in the position of the uterus (such as associated with tearing or damage to the uterine wall and associate ligament structure). Other conditions associated with the uterus include the formation of carcinomas (malignant tumors or growths), fibroids, adenomyosis, pyometra, uterine malformations, as well as Asherman's syndrome.
- In view of the above description, and referring initially to
FIG. 1 , an enlarged environmental perspective is shown of ahuman cervix 1 to which a medicinal delivery device, generally at 10, is secured at a surface location. Thedelivery device 10 exhibits, in one non-limiting configuration, a depressible and suction inducingmiddle component 12 constructed of a soft and easily deformable plastic along with an outer and suction maintainingannular skirt 14 which is usually constructed of a somewhat more durable and less flexible polymer or polymer composite. - As is known, the exterior surface of the cervix exhibits a very moist consistency which is particularly amenable to retaining in location an exteriorly suction attachable component as is provided by the
device 10. Referring to the rotated underside inFIG. 2 of themedicinal delivery device 10, additionally illustrated is the concentric arrangement of suction and medicinal incorporating areas in an alternating pattern and which, upon being suction engaged in the manner described herein, facilitates the contact of the medicinal areas (or components shown at 16 and 18) in contact with the surface of thecervix 1. - Alternating with the annular shaped
medicinal areas zones vacuum aperture location 26 defining a rigid push-button depicted at an embedded underside of the general dome-shaped and suction inducingmiddle component 12. Without limitation, the medicinal impregnated or entrainedareas - Proceeding to
FIG. 3 , an illustration similar toFIG. 2 is shown of an alternate underside configuration of a medicinal delivery device in which the suction generating areas are reconfigured as shown at 28, 30 and 32 in alternating arrangement with suction inducing/retainingareas 34 and 36. As depicted, the suction generating areas 28-32 each exhibit a grooved profile and further include strategically placed vacuum apertures (at 38 forcentral-most suction area 32 as well as in circumferentially arrayed fashion at 40, 42, 44 and 46 dispersed along intermediate suction area 30). -
FIG. 4 is an upper side perspective similar toFIG. 1 of an alternate configuration, generally at 48, of medicinal delivery device in which the single large suction pad is reconfigured as a plurality of smaller and individually suction generatingpads body 62.FIG. 5 is a rotated underside of the medicinal delivery device ofFIG. 4 and which again illustrates the interior configuration of the suction pads 50-60, along with the arrangement of themedicinal delivery surface 64 surrounding the individual dispersed suction pads and communicating with the underside perimeter edge of the dome shapedbody 62. As further shown inFIG. 5 , underside accessible apertures 66-76 are provided respectively for each of the individual suction pads 50-60 and which function in a similar manner as previously described for adhering to the moist exterior of the uterus, as shown inFIG. 4 , and upon which the soft and deformable/collapsible and individual pads 50-60 being progressively depressed to create a multiple of individual contact locations for providing redundancy in adhering to the uterine surface while maintaining themedicinal delivery area 64 in continuous contact with the surface of the uterus or other desiredorgan 1. - Proceeding to
FIG. 6 , an underside perspective is shown of a species variation of the embodiment generally shown inFIG. 5 , in which the dome shapedsuction body 62 and undersidemedicinal delivery component 64 are identical to that inFIG. 5 , and in which the individual suction pads are reconfigured as shown at 78-88, such that each includes an inner hemispherical underside projection 90-100 with an inner aperture 102-112 (mimicking a generally octopus tentacle like arrangement) to assist in suction generation. Beyond the configuration shown, it is understood that the individual suction generating areas can be reconfigured or redesigned in any of a number of non-limiting designs and which, upon depressing the softouter dome 62, facilitate enhanced and secure adherence to the moist surface of the cervix (or other organ). -
FIG. 7 is an illustration of an environmental perspective, generally at 114, of a uterine attachable medicinal delivery device according to a yet further variant. The integral and dome shaped body is generally redesigned to include anouter-most skirt portion 118 and anintermediate portion 120 separated by a groovedannular boundary 122. An inner most raised orprotuberance location 124 of the body exhibits a central nipple aperture formed into asoft sealing material 126 for receiving a tip of an insertedneedle 128 in order to create a retaining suction with the cervix surface exterior. -
FIG. 8 is a rotated underside of the medicinal delivery device ofFIG. 7 exhibiting a pattern generally identical to that depicted inFIG. 2 , and in which theouter perimeter edge 118 extends to an underside lip of the body and which, combined with the intermediate annulargrooved boundary 122, separatesmedicinal delivery areas medicinal delivery areas FIG. 7 and further such that theneedle tip 128 is evident from the exteriorly inserting location for generating the desired retaining suction within the underside interior for locating and holding the device in place upon the cervix exterior wall. -
FIG. 9 is an environmental perspective of a medicinal delivery device, generally at 134, according to a further variant attached to thecervix exterior 1. A generally dome shaped body is depicted at 136 terminating in a sealing lip underside 138 (seeFIG. 10 ) which is similar to the previously described configurations and which assists in contact and vacuum adherence to the moist surface of the cervix or other desired organ. - A central area is depicted in substantially transparent fashion in
FIG. 9 and includes a central and innersuction inducing chamber 140 which is individually communicated to each of a plurality of outer and perimeter arranged vacuum chambers 142-156 (these depicted as individual and generally trapezoidal shaped sub-chambers separated by anannular wall 158 defining the innersuction inducting chamber 140 and outer radial ribs 160-174 respectively separating the outer chambers 142-156. Each of the outer chambers 142-156 further includes a vacuum communicating aperture defined by an inner closed perimeter 176-190 associated with a base surface of each chamber separated by the projecting ribs. - As previously described, the desired suction effect results from the exterior dome shaped
body 136 being collapsed, via the interior orcentral chamber 140, to issue airflow through each of the apertures (such as each of which can include one-way valves), with the reverse incentive of thebody 136 to reform to its original three dimensional shape being opposed by the vacuum created effects within each of the outer chambers and in order to drawn into open undersides of each outer chamber 142-156 moistened surface locations of the cervix wall to establish the desired vacuum adherence in like multiple/redundant fashion. Also depicted inFIG. 10 is a first and generally outer and annular shapedmedicinal delivery layer 192 interposed between an inner extending edge of theunderside lip 138 and the dome shapedbody 136, combined with an inner most medicinal delivery layer orarea 194 which closes off thecentral chamber 140, the medicinal layers both configured and operational in a manner as previously described for facilitating in time release delivery of a desired entrained medicinal composition in surface applied fashion to the desired organ via its moistened exterior. -
FIG. 11 is a perspective view, generally at 198, of a medicinal delivery device according to a further variant which includes a modified and generally three dimensionalshaped body 200 in which the suction generating aspects are substituted by underside projecting prongs 202-210 (see alsoFIG. 12 underside) for engaging or piercing through the outer layers associated with the cervix or other organ wall. As shown, the prongs 202-210 each include intermediate angled winglets, for example depicted at 203 and 205 for selectedprong 202 and which further terminates in apointed end 207. - As further depicted from the underside of
FIG. 12 , a substantially flattened and disc shaped internal layer is shown at 212 which again comprises the medicinal delivery component and which extends to anunderside lip 214 associated with thebody 200, as well as through which the individual prongs project. Without limitation, other mechanical attachment mechanism can be substituted for that shown and which can operate according to any desired fashion for securing the device to the desired exterior location of the organ. -
FIGS. 13A-13C are representative illustrations of different sized medicinal delivery devices, such as respectively depicted at each of 10′, 10″ and 10′″ consistent with the initial disclosed variant, and which are adapted for implantation according to the present inventions according to any desired plural scale or arrangement. It is worth noting that the delivery devices not limited to the several examples disclosed can be provided in any number and/or size for addressing a given internal organ condition and in which a desired surface application of medicine is achieved through a specified placement pattern or protocol. - Referring now to
FIG. 14 , a perspective illustration is generally shown at 216 of an insertion tool for delivery and implanting a medicinal delivery device such as according to any of the prior variants disclosed and which is further depicted generally at 218, and which can be provided as any of a system, combination or kit. Features associated with the tool 216 (such as which can include a medical grade steel or sanitary plastic) include such as anelongated stem 220 separating a bulbous (handling and gripping)end 222 and a forward most located insitu delivery end 224. - As further shown, the non-limiting depiction of the
forward delivery end 224 is exhibited by a generally cylindrical profile which matches that of themedicinal delivery device 218. As further best shown inFIG. 14 , a plurality (such as four) of perimeter located and arcuate profile clamps 226, 228, 230 and 232 are exhibited about the exposed facing circumference of thedelivery end 224 of the tool, these gripping circumferential perimeter locations of themedicinal delivery device 218 as shown inFIGS. 14 and 15 . - As partially depicted in each of
FIGS. 15 and 16 , and as further best shown in longitudinally cutawayFIG. 17 , an upper mostarcuate surface 234 of thedelivery device 218 exhibits vacuum adhering aspects as influenced by the interior geometry of the tool, which exerts a vacuum force on thedelivery device 218 in a first clamping/vacuum gripping configuration. A two part trigger mechanism is further depicted bytoggle portions stem 220. -
FIG. 15 depicts the clamping and vacuum adhering aspects of the tool engaged (see directional arrows associated with thetoggles 236 and 238), whereasFIG. 16 further shows thetoggles flexible surface 234 associated with thedelivery device 218, at which point the delivery device is released from the insertingend 224 of the tool and permitted to be implanted at the desired in situ location of the patient. -
FIG. 17 is an enlarged, reduced length and longitudinal cutaway view of thetool 216 ofFIG. 15 better depicting the structure for accomplishing both perimeter clamp and vacuum release of the medicinal delivery device. As shown, this includes thetoggle 236 manipulating an interiordisplaceable sleeve 236 with forward depictedprofile 238 for both inducing and releasing the suction inducing effect for gripping theflexible surface 234 of the delivery device 218 (such as further depicted by suction inducing (rearward) directional translation 240 (toggle 236 to position ofFIG. 15 ) and suction releasing (forward) translation 242 (toggle to position ofFIGS. 16-17 ). -
Toggle 238 in the longitudinal cutaway ofFIG. 17 actuates an outer coaxial sleeve (see cutaway locations both identified at 244) this encapsulating the inner displaceable and vacuum inducing/releasingsleeve 236. Theouter sleeve 244 terminates as an annular and enlarged end profile as engaginglocations 246 and 248 associated with selectedclamps toggle 238 being actuated as directionally indicated inFIG. 17 to the release position, thesleeve 244 with end configured and laterallydisplaceable profile locations 246 and 248 (two additional perimeter locations associated withadditional clamps FIG. 17 ) are rearwardly displaced (see arrow 250) to open the clamps (see alsoarrow 252 relating to selected clamp 230). Without limitation, a number of fulcrum or pivotal actuating structures can be integrated into the tool geometry which cause the necessary pivotal actuation of the clamps 226-232 in the desired fashion depicted, this in response to actuation of thetoggle 238. - Referring to
FIG. 18 , a front perspective view is generally shown at 254 of an implantable medicinal delivery device according to a further embodiment and which exhibits an outer perimeter (generally annulus shaped)body 256 having a semi-flexible and semi-rigid configuration for implantation and subsequent removal to and from the patient. Thebody 256 contains amedicinal delivery component 258. A further plurality of perimeter configured and movable gripping portions are depicted at 260, 262, 264 and 266, these each further shown by blade edged outer tab locations as best shown inFIG. 18 which are configurable for engaging an in situ implantation location within the patient. -
FIG. 19 is a rotated rear perspective view of thedelivery device 254 shown inFIG. 18 which includes arear surface 268 associated annular shapedbody 256, along with a central and rearward projecting/tool gripping post 270. A further plurality of outer perimeterinsertion tool locations gripping portions -
FIG. 20 is a plan view of themedicinal delivery device 254 ofFIG. 18 in use with a modified and inserting delivery tool, generally at 280, and in which a forward engaging configuration of the tool is exhibited by multiple and circumferentially offset gripping fingers, these shown by gripingfingers portions gripping finger 262. As further depicted inFIG. 20 , thetool 280 includes abulbous handling profile 288 and an intermediate stem locatedtrigger 290 in a first open location in which the gripping fingers of the tool are seated rearwardly into contact with the interior communicating pockets of the gripping portions 260-266 in a first open/non-engaging position. - Proceeding to
FIG. 21 ,trigger 290 is depicted as actuated in adirection 292, this in order to actuate the gripping fingers 282-286 and associated gripping portions 260-266 in order to inwardly deflect the gripping portions in order to grab onto and retain contact with an associated implantation location of the patient (such as associated with an organ location in situ a cancerous growth or other tumor). Given the material construction of the outer annular portion of the delivery device as well as the gripping fingers, this can include either piercing the outer skin of the tumor or otherwise embedding into the tumor and subsequently deflecting the outer circumferential gripping portions in a manner which ensures location maintenance for the time period between an initial implantation and subsequent removal, such as which again uses the installation tool described herein. -
FIG. 22 is an enlarged delivery end and longitudinal cutaway view of the tool ofFIG. 20 and which better depicts the inter-actuating linkages for controlling selected illustratedgripping fingers engaging locations stem 296, this connected through a fulcrum linkage to thetrigger 290 in such a fashion as to pivotally actuate forward angledinter-linkages stem 296 to rearward linkage engagement locations with the selected grippingfingers - The gripping fingers are in turn mounted to inner fixed pedestal supports (see further at 302 and 304) and which, upon actuating the
stem 296 in a rearward displaceable direction causes the gripping portions 260-266 to bite inwardly. Subsequent forward displacement of theinner stem 296 of the tool in turn results in counter pivoting of the gripping portions to outwardly displace or release from the organ or tissue implantation location. -
FIG. 23 is an illustration of a modified inserting end of an installation tool such as similar to that depicted inFIG. 20 and in which a high intensity light source, see as depicted by dome shapedelement 306 not limited to an LCD, LED or other portable and high intensity emitting element, is integrated into the tool proximate the forward implantation end. This is further depicted by a seating location 380 which is mounted atop a narrowed crosssectional bridge 310 in order to be situated at an elevated location and minimally visibly obtrusive fashion while remaining proximate to the medicinal delivery location and in order to facilitate correct location and delivery of the medicinal delivery device. Associated illumination structure, including a portable battery or other power source, can be integrated into the tool for operating the light 306, such as which can be actuated on/off by a suitably located switch. - Having described my invention, other and additional preferred embodiments will become apparent to those skilled in the art to which it pertains, and without deviating from the scope of the appended claims. This can include the medicinal delivery device according to any of the previously disclosed variants, further being adapted to engagement with any other human and/or mammalian type internal organ, not limited to bowels, kidney, liver, lungs, and the like.
Claims (17)
1. A medicinal delivery device adapted to being applied to a surface of an internal organ, comprising:
a three dimensional shaped body exhibiting an upper surface and at least one underside layer within which is entrained a medicinal application layer; and
upon adhering said underside to an exterior of the organ, said body providing for controlled and time release delivery of medication to the organ.
2. The medicinal delivery device according to claim 1 , said body further comprising a deformable upper portion in combination with at least one underside and suction inducing location.
3. The medicinal delivery device according to claim 2 , said medicinal and suction inducing locations further comprising concentrically arranged layers.
4. The medicinal delivery device according to claim 3 , further comprising an aperture located within an enclosed inner defined volume associated with said suction inducing location.
5. The medicinal delivery device according to claim 2 , said body further comprising a plurality of individual and suction inducing pads.
6. The medicinal delivery device according to claim 5 , said suction inducing pads further comprising octopus style suction cups.
7. The medicinal delivery device according to claim 3 , further comprising a needle inserted through a soft self-sealing material incorporated within said body for creating internal suction.
8. The medicinal delivery device according to claim 2 , said body further comprising an inner suction chamber interconnected with a plurality of individual outer and perimeter extending chambers.
9. The medicinal delivery device according to claim 1 , further comprising a plurality of underside projecting prongs for attaching said body to the organ.
10. The medicinal delivery device according to claim 1 , further comprising a tool for implanting the delivery device.
11. The medicinal delivery device according to claim 10 , said tool further comprising an elongated body with forward actuating gripping fingers for locating and implanting said three dimensional shaped body of the delivery device.
12. The medicinal delivery device according to claim 10 , said three dimensional shaped body further comprising inwardly deflectable gripping portions accessible through recessed locations exhibited on a rear surface of said body.
13. The medicinal delivery device according to claim 11 , further comprising a trigger on said tool for activating said gripping fingers.
14. The medicinal delivery device according to claim 10 , further comprising said tool exerting a vacuum retaining force on a flexible surface of said three dimensional shaped body.
15. The medicinal delivery device according to claim 10 , said tool further comprising a light source for assisting in implantation of said three dimensional shaped body.
16. A medicinal delivery device adapted to being applied to a surface of an internal organ, comprising:
a three dimensional shaped body exhibiting an upper surface and at least one underside layer within which is entrained a medicinal application layer;
said body further having a deformable upper portion in combination with at least one underside and suction inducing location, said body further including a plurality of individual and suction inducing pads; and
upon adhering said underside to an exterior of the organ, said body providing for controlled and time release delivery of medication to the organ.
17. A medicinal delivery device adapted to being applied to a surface of an internal organ, comprising:
a three dimensional shaped body exhibiting an upper surface and at least one underside layer within which is entrained a medicinal application layer;
a tool for implanting the delivery device, said tool including an elongated body with forward actuating gripping fingers for locating and implanting said three dimensional shaped body of the delivery device, a trigger on said tool for activating said gripping fingers; and
upon adhering said underside to an exterior of the organ, said body providing for controlled and time release delivery of medication to the organ.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/047,409 US20140100530A1 (en) | 2012-10-05 | 2013-10-07 | Attachable uterine device with integrated and time release medicinal administering component and insertion tool for implanting such a device |
US14/820,149 US9827406B2 (en) | 2012-10-05 | 2015-08-06 | Insertion tool for implanting a medicinal delivery device upon an internal organ |
US14/946,421 US20160074640A1 (en) | 2012-10-05 | 2015-11-19 | Attachable uterine device with integrated and time release medicinal administering component and insertion tool for implanting such a device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261710079P | 2012-10-05 | 2012-10-05 | |
US14/047,409 US20140100530A1 (en) | 2012-10-05 | 2013-10-07 | Attachable uterine device with integrated and time release medicinal administering component and insertion tool for implanting such a device |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/820,149 Division US9827406B2 (en) | 2012-10-05 | 2015-08-06 | Insertion tool for implanting a medicinal delivery device upon an internal organ |
US14/946,421 Continuation-In-Part US20160074640A1 (en) | 2012-10-05 | 2015-11-19 | Attachable uterine device with integrated and time release medicinal administering component and insertion tool for implanting such a device |
Publications (1)
Publication Number | Publication Date |
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US20140100530A1 true US20140100530A1 (en) | 2014-04-10 |
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ID=50433264
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/047,409 Abandoned US20140100530A1 (en) | 2012-10-05 | 2013-10-07 | Attachable uterine device with integrated and time release medicinal administering component and insertion tool for implanting such a device |
US14/820,149 Expired - Fee Related US9827406B2 (en) | 2012-10-05 | 2015-08-06 | Insertion tool for implanting a medicinal delivery device upon an internal organ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/820,149 Expired - Fee Related US9827406B2 (en) | 2012-10-05 | 2015-08-06 | Insertion tool for implanting a medicinal delivery device upon an internal organ |
Country Status (1)
Country | Link |
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US (2) | US20140100530A1 (en) |
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Also Published As
Publication number | Publication date |
---|---|
US9827406B2 (en) | 2017-11-28 |
US20150335868A1 (en) | 2015-11-26 |
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Legal Events
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STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |