US20140216252A1 - Arrangement for removing carbon dioxide from an extracorporeal flow of blood by means of inert gases - Google Patents
Arrangement for removing carbon dioxide from an extracorporeal flow of blood by means of inert gases Download PDFInfo
- Publication number
- US20140216252A1 US20140216252A1 US14/234,939 US201214234939A US2014216252A1 US 20140216252 A1 US20140216252 A1 US 20140216252A1 US 201214234939 A US201214234939 A US 201214234939A US 2014216252 A1 US2014216252 A1 US 2014216252A1
- Authority
- US
- United States
- Prior art keywords
- gas
- blood
- purge gas
- flow
- carbon dioxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/025—Helium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0258—Krypton (KR)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0291—Xenon
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/0031—Degasification of liquids by filtration
Abstract
Description
- This application is entitled to the benefit of and incorporates by reference subject matter disclosed in International Patent Application No. PCT/EP2012/064801 filed on Jul. 27, 2012 and German Patent Application No. 10 2011 052 187.9 filed Jul. 27, 2011.
- The invention relates to an arrangement for removing carbon dioxide from an extracorporeal flow of blood, the arrangement comprising a filter having a membrane that separates a blood region from a gas region. The extracorporeal flow of blood is passed through the blood region of the filter, and a gas flow of a purge gas is passed through the gas region of the filter.
- In medicine, in the case of seriously ill patients so-called oxygenators are used to remove carbon dioxide from the blood of these patients and to oxygenate the blood. Nowadays, oxygenators comprising a membrane by which a blood region is separated from a gas region are used almost exclusively. The blood is taken from a main vessel of the patient and is fed into the blood region of the oxygenator preferably by means of a blood pump. At the same time, a purge gas is transported through the gas region, normally either pure oxygen or a mixture of oxygen and nitrogen being used as a purge gas. In particular, a mixture of 21% oxygen and 79% nitrogen, so-called AIR, is used. The purge gas is in particular taken from wall supplies available in medical facilities and thus meets the requirements of medical gases.
- As a result of the pressure gradient of the partial pressure or the concentration gradient of the carbon dioxide, carbon dioxide is transported from the blood region through the membrane and into the gas region, whereas as a result of the partial pressure gradient of the partial pressure of the oxygen or the concentration gradient of the oxygen, the oxygen is transported through the membrane from the gas region into the blood region so that the blood is oxygenated while at the same time carbon dioxide is removed from the blood. The amount of carbon dioxide that is removed from the blood per unit of time, and the amount of oxygen with which the blood is oxygenated per unit of time depend, on the one hand, on the flow rate of the purge gas through the gas region and, on the other hand, on the transport rate of the blood through the blood region.
- In known arrangements, the purge gas always comprises oxygen so that an oxygenation of the blood inevitably takes place even if the breathing capacity of the patient himself/herself were sufficient to ensure sufficient oxygen supply, and it were only necessary to remove the carbon dioxide from the blood. The unnecessary enrichment of the blood by means of the oxygenator can result in a hypoxic pulmonary vasoconstriction with a corresponding shunt shift so that the already ill patient is stressed further and his recovery is hindered. Depending on the purge gas used, moreover further gases may be transferred from the purge gas into the blood, which may also result in irritations of the patient.
- It is the object of the invention to specify an arrangement for removing carbon dioxide from an extracorporeal flow of blood, by means of which the carbon dioxide can be gently removed from the flow of blood.
- This object is solved by an arrangement having the features of claim 1. Advantageous developments of the invention are specified in the dependent claims.
- According to the invention, this object is solved in that as a purge gas an inert gas or a mixture of inert gases is used. Thus, it is achieved that the purge gas does not enter into combination with the extracorporeal flow of blood so that no gases are supplied to the flow of blood but only carbon dioxide is removed from the extracorporeal flow of blood as a result of the partial pressure gradient or concentration gradient existing between the blood region and the gas region.
- In this connection, a gas that does not enter into combination with blood is understood as an inert gas.
- In case that only one inert gas is used as a purge gas, preferably nitrogen or a noble gas, in particular helium, neon, xenon, argon or krypton is used as an inert gas. When using a mixture of inert gases as a purge gas, a mixture of nitrogen and at least one noble gas or a mixture of at least two noble gases is used, accordingly.
- As a filter, in particular an oxygenator is used so that carbon dioxide can be gently removed from the blood in an easy manner. Preferably, a blood pump is provided by means of which the flow of blood is transported through the blood region.
- Further, a gas supply unit for generating a gas flow of the purge gas can be provided. The gas supply unit preferably comprises a gas blender by which the purge gas can be mixed from several inert gases. In addition, the gas supply unit can comprise a ventilator by means of which the gas flow of purge gas is generated. Alternatively, a gas supply unit can be dispensed with. In this case, the flow is generated by the pressure of the inert gas or the inert gases with which they are provided.
- It is advantageous when at least one storage tank is provided, in which the purge gas is contained. The storage tank is connected to the filter via a supply line. Alternatively, also several storage tanks can be provided, wherein in this case a glas mixing unit, a so-called gas blender is provided, via which the gases contained in the storage tanks are mixed into the purge gas before the purge gas is then supplied to the supply line and, via this supply line, to the filter.
- In a particularly preferred embodiment, a return line for returning the purge gas from the filter into the supply line is provided so that the purge gas can be used once again. Thus, the inert gases can be used several times, which, in particular when using noble gases as inert gases, results in a cost reduction.
- In the area of the return line, in particular a cleaning unit for the at least partial removal of the carbon dioxide from the gas fed through the return line is provided. The cleaning unit removes in particular the entire carbon dioxide contained in the gas fed through the return line so that after passage through the cleaning unit the gas no longer contains any carbon dioxide and thus can be re-used for flowing through the gas region of the filter. The return line is in particular also connected to the gas blender so that via the gas blender the supplied gas can be mixed with the gas taken from the storage tank and thus the desired composition of the purge gas can be produced at any time.
- For maintaining an adjustable flow rate in the return line, a gas transport unit is assigned to the system (preferably a turbine) is added. The transport capacity is subordinated to the adjustable gas flow through the filter and can be selected by the user.
- Further, it is advantageous if a sensor for determining the carbon dioxide content of the purge gas is provided downstream of the filter. By means of this sensor it can in particular be monitored that the purge gas supplied to the filter does not contain any carbon dioxide so that the desired partial pressure gradient or concentration gradient of the carbon dioxide between the gas region and the blood region is established and the desired transfer capacity of carbon dioxide from the flow of blood into the purge gas is guaranteed.
- Additionally or alternatively, a sensor for determining the carbon dioxide content of the purge gas can also be provided downstream of the filter so that by comparing the carbon dioxide content upstream and downstream of the filter, it can be determined how much carbon dioxide has been removed from the extracorporeal flow of blood via the filter. Thus, it can be monitored easily whether the desired preset transfer capacity of the carbon dioxide has actually been achieved. In particular, a monitoring of the condition of the patient is thus possible.
- Further, it is advantageous if a respective sensor for determining the flow rate of the purge gas is provided downstream and/or upstream of the filter. Thus, the flow rate of the purge gas can easily be monitored, and in particular by comparing the determined flow rate or the determined flow rates to a preset desired value and a corresponding control of the flow rate it can be guaranteed that the preset flow rate is actually kept so that the desired preset transfer capacity is achieved.
- Further, the arrangement comprises in particular a control unit which controls the gas supply unit such that the gas supply unit supplies the purge gas to the filter at a preset flow rate. The gas supply unit is in particular dimensioned such that by means of it flow rates between 0.1 l/min and 20 l/min can be realized so that a correspondingly large range of transfer capacities is possible and thus the amount of carbon dioxide to be removed can be adapted to the condition of the patient as exactly as possible.
- In a particularly preferred embodiment, the control unit comprises an input and/or output unit for the output of information to an operator and/or for the input of information by the operator. The output information in particular comprises the carbon dioxide contents of the purge gas determined by means of the sensors and/or the determined flow rates so that the operator can easily monitor whether the planned amount of carbon dioxide has been removed from the flow of blood. The input information preferably comprises control data by means of which the operator can control the arrangement. In particular, the operator can set the desired flow rate of the purge gas and/or the composition of the purge gas via the input unit and can thus also ensure how much carbon dioxide is removed from the extracorporeal flow of blood. The input and output unit is in particular designed as a touchscreen so that only one single unit is required for input and output, and this single unit can be operated by the operator easily and intuitively. Thus, input errors are avoided and a simple handling is achieved.
- A further aspect of the invention relates to a method for removing carbon dioxide from an extracorporeal flow of blood in which a flow of blood is passed through a blood region of a filter separated from a gas region by a membrane and in which a gas flow of a purge gas is passed through the gas region. As a purge gas, an inert gas or a mixture of inert gases is used, in particular nitrogen or a noble gas being used as an inert gas or a mixture of nitrogen and at least one noble gas or a mixture of at least two noble gases being used as a mixture.
- Further features and advantages of the invention result from the following description which explains the invention on the basis of embodiments in connection with the attached Figures, in which:
-
FIG. 1 shows a schematic illustration of an arrangement for removing carbon dioxide from an extracorporeal flow of blood according to a first embodiment. -
FIG. 2 shows a schematic illustration of an arrangement for removing carbon dioxide from an extracorporeal flow of blood according to a second embodiment. -
FIG. 3 shows a schematic illustration of an arrangement for removing carbon dioxide from an extracorporeal flow of blood according to a third embodiment. - In
FIG. 1 , a schematic illustration of anarrangement 10 for removing carbon dioxide from an extracorporeal flow of blood of a patient is illustrated. Thearrangement 10 comprises a filter designed as anoxygenator 12 and having ablood region 14 and agas region 18 separated from thisblood region 14 via amembrane 16. The extracorporeal flow of blood is passed through theblood region 14 according to the arrows P1 and P2, for which asupply line 20 and adischarge line 22 are provided. - A purge gas contained in a
storage tank 24 and supplied to thegas region 18 via asupply line 26 is passed through thegas region 18, which is indicated by the arrow P3. - According to the invention, an inert gas or a mixture of inert gases is used as a purge gas, wherein each gas that does not enter into combination with blood can be used as an inert gas. As a result of the pressure difference of the partial pressure of the carbon dioxide between the
blood region 14 and thegas region 18 or the concentration difference between theblood region 14 and thegas region 18, carbon dioxide is removed from the flow of blood through themembrane 16 and is supplied to the purge gas so that the carbon dioxide content of the flow of blood is reduced. Since the inert gas used as a purge gas or the mixture of inert gases used as a purge gas cannot itself enter into combination with the blood, no enrichment of the flow of blood with the inert gas takes place. As the inert gas in particular does not comprise any oxygen, merely a removal of the carbon dioxide from the flow of blood but no oxygenation of the flow of blood takes place by theoxygenator 12. Thus, the patient, from which the flow of blood is taken, is not irritated by the enrichment with oxygen so that in particular a hypoxic pulmonary vasoconstriction with a corresponding shunt shift is prevented. Hereby, also other negative influences on the blood-gas-related supply condition of the already critically ill patient are prevented. Shunt shift in this connection means that the limit up to which the fine blood vessels of the lung are supplied with blood changes. - As an inert gas, in particular nitrogen or a noble gas or a mixture of the afore-mentioned gases is used. As a noble gas, in particular helium, neon, argon, krypton or xenon is used.
- The purge gas enriched with the carbon dioxide is discharged via the
discharge line 28 and is, for example, supplied to a recycling system. - Further, the
arrangement 10 comprises acontrol unit 30, twocarbon dioxide sensors flow rate sensors carbon dioxide sensor flow rate sensor oxygenator 12 and downstream of theoxygenator 12. - The
control unit 30 has atouchscreen 40 by means of which information can be output to an operator of thearrangement 10 and information, in particular data for controlling thearrangement 10, such as a desired amount of carbon dioxide to be removed from the extracorporeal blood flow, can be input. The values determined by means of thesensors 32 to 38 are in particular displayed to the operator via thetouchscreen 40 so that the operator can easily monitor the planned function of thearrangement 10. In particular, thecontrol unit 30 determines a difference value from the value determined by means of thecarbon dioxide sensor 34 and the value determined by means of thecarbon dioxide sensor 32 so that via a—in particular graphic—display of this difference value the operator can easily see how much carbon dioxide has been removed from the flow of blood. - Further, the operator can set the flow rate at which the purge gas is to flow through the
gas region 18 via thecontrol unit 30 so that via the flow rate the transfer capacity of the carbon dioxide, i.e. the amount of carbon dioxide which is removed from the flow of blood can easily be controlled. The flow rate is in particular settable in a range between 0.1 l/min and 20 l/min. For this, thecontrol unit 30 controls thestorage tank 24, in particular a valve of thestorage tank 24 such that this storage tank supplies a purge gas flow at a corresponding flow rate into thesupply line 26 and thus to thegas region 18. - In a preferred embodiment, a closed-loop control system is formed by the
flow rate sensor 36 and/or theflow rate sensor 38. In this case, thecontrol unit 30 compares the actual value of the flow rate of the purge gas determined by theflow rate sensor 36 and/or by theflow rate sensor 38 to a preset desired value of the flow rate and controls thestorage tank 34 such that the actual value corresponds to the desired value. - In an alternative embodiment, it is likewise possible that the flow of the purge gas is not exclusively generated via the pressure with which the purge gas is contained in the
storage tank 24, but a further separate gas supply unit for generating the flow of purge gas through thegas region 18 is provided. - In
FIG. 2 , a schematic illustration of anarrangement 100 for removing carbon dioxide from an extracorporeal flow of blood according to a second embodiment is illustrated. The second embodiment differs from the first embodiment shown inFIG. 1 in that the purge gas is not disposed after passage through thegas region 18, but is supplied to thesupply line 26 via areturn line 102, as indicated by the arrow P4, so that the purge gas can be used several times. Thus, it is not necessary to always take “fresh” purge gas from thestorage tank 24 and to supply it to thegas region 18. - In the area of the
return line 102, acleaning unit 104 for removing carbon dioxide from the purge gas returned by the return line is provided. Thiscleaning unit 104 is in particular designed such that by means of this cleaning unit the carbon dioxide can be completely removed from the purge gas so that only pure purge gas without carbon dioxide is supplied to thesupply line 26. Alternatively, only a part of the carbon dioxide can be removed as well. Thecleaning unit 104 is in particular designed such that therein in the purge gas being passed through the carbon dioxide contained in the purge gas is bound and thus removed from the purge gas by chemical processes such as under adsorption through a container with soda or soda line or equipped with a further permeable membrane. - Further, in the return line 102 a
ventilator 106 is arranged, by which the gas flow of the purge gas is maintained. - In
FIG. 3 , a schematic illustration of anarrangement 200 for removing carbon dioxide from an extracorporeal flow of blood according to a third embodiment is illustrated. In contrast to the first two embodiments, thearrangement 200, in this third embodiment, has not only onestorage tank 24 filled with a gas, but threestorage tanks 24 each filled with gas. Thestorage tanks 24 are each connected via aline 202 to agas mixing unit 204 which is also referred to as a gas blender so that via thegas mixing unit 204 the purge gas that is thereafter fed from thegas blender 204 to theoxygenator 12 is mixed from the gases contained in thestorage tanks 24. In thestorage tanks 24 in particular one inert gas each is contained so that via the gas mixing unit 204 a mixture of these inert gases can be mixed as a purge gas. Alternatively, in one or more storage tanks 24 a mixture of inert gases can already be contained. - Via the
gas mixing unit 204 also only one of the gases contained in thestorage tanks 24 can be supplied to thesupply line 26 so that in this case merely this one gas serves as a purge gas. Thus, thegas mixing unit 204 can serve, on the one hand, to mix a purge gas from several gases and, on the other hand, also to allow for an option of the purge gas without thestorage tank 24 having to be changed for this. - The
return line 102 is in particular also connected to thegas mixing unit 204 so that the returned purge gas can be mixed via thegas mixing unit 204 with gases that are possibly taken from thestorage tanks 24. Alternatively, the connection of thereturn line 102 to thesupply line 26 can also be realized downstream of thegas mixing unit 204. - Further, it is alternatively possible that more than three
storage tanks 24, for example fourstorage tanks 24, or also only twostorage tanks 24 are provided. - Further, it is alternatively possible that only in some of the
storage tanks 24 inert gases and in theother storage tanks 24 no inert gases, for example oxygen or an oxygen-nitrogen-mixture, is contained. Hereby, it is achieved that patients from which not only carbon dioxide is to be removed from the flow of blood but the flow of blood also has to be enriched with oxygen, for example because the own breathing capacity of the patient is not sufficient therefor, this can take place via thesame arrangement 200. - The composition of the purge gas from the gases contained in the
storage tanks 24 can in particular be set via thecontrol unit 30. Thus, the composition of the purge gas can easily be adapted to the respective patient-dependent circumstances. - In a further alternative embodiment of the invention, as in the third embodiment, also
several storage tanks 24 can be provided, from which gases the purge gas can be mixed by means of agas mixing unit 204 and, on the other hand however, as in the first embodiment according toFIG. 1 , no return of the purge gas after passage through theoxygenator 12 takes place. In this case, the purge gas is disposed and/or recycled after passing through theoxygenator 12. - Although various embodiments of the present invention have been described and shown, the invention is not restricted thereto, but may also be embodied in other ways within the scope of the subject-matter defined in the following claims.
Claims (15)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011052187 | 2011-07-27 | ||
DE102011052187A DE102011052187A1 (en) | 2011-07-27 | 2011-07-27 | Arrangement for removing carbon dioxide from an extracorporeal blood stream by means of inert gases |
DE102011052187.9 | 2011-07-27 | ||
PCT/EP2012/064801 WO2013014276A1 (en) | 2011-07-27 | 2012-07-27 | Assembly for removing carbon dioxide from an excorporeal blood flow by means of inert gases |
Publications (2)
Publication Number | Publication Date |
---|---|
US20140216252A1 true US20140216252A1 (en) | 2014-08-07 |
US9320844B2 US9320844B2 (en) | 2016-04-26 |
Family
ID=46724347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/234,939 Active 2032-08-16 US9320844B2 (en) | 2011-07-27 | 2012-07-27 | Arrangement for removing carbon dioxide from an extracorporeal flow of blood by means of inert gases |
Country Status (5)
Country | Link |
---|---|
US (1) | US9320844B2 (en) |
EP (2) | EP2736556B1 (en) |
CN (1) | CN103842002A (en) |
DE (1) | DE102011052187A1 (en) |
WO (1) | WO2013014276A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210113755A1 (en) * | 2018-03-02 | 2021-04-22 | Spectrum Medical Ltd. | Oxygenation system |
US20210369931A1 (en) * | 2018-05-22 | 2021-12-02 | Spectrum Medical Ltd | Blood processing system |
WO2023239281A1 (en) * | 2022-06-09 | 2023-12-14 | Maquet Critical Care Ab | Control of carbon dioxide transfer in oxygenator for extracorporeal blood gas exchange |
WO2023239283A1 (en) * | 2022-06-09 | 2023-12-14 | Maquet Critical Care Ab | Multisampling sidestream gas analyser for gas exchange analysis |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110234370B (en) | 2016-09-22 | 2022-04-05 | C·J·普洛特 | Device and method for extracorporeal blood regulation |
DE102016015059B4 (en) | 2016-12-19 | 2020-11-12 | Drägerwerk AG & Co. KGaA | Device for extracorporeal blood gas exchange |
CN115998976A (en) | 2017-08-15 | 2023-04-25 | 马里兰大学巴尔的摩 | Dual chamber gas exchanger and method for respiratory support |
DE102020104117A1 (en) * | 2020-02-18 | 2021-08-19 | Universität des Saarlandes | Device for removing a gas from an aqueous liquid |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5277176A (en) * | 1992-06-29 | 1994-01-11 | Habashi Nader M | Extracorporeal lung assistance apparatus and process |
US20040057869A1 (en) * | 2000-11-28 | 2004-03-25 | John Dingley | Gas exchange |
US20060144235A1 (en) * | 2002-12-02 | 2006-07-06 | Molecular Products Limited | Apparatus and process for carbon dioxide absorption |
US20060231098A1 (en) * | 2002-05-01 | 2006-10-19 | Air Products And Chemicals, Inc. | Medical gas recirculation system |
US20100143192A1 (en) * | 2008-12-04 | 2010-06-10 | Therox, Inc. | Method and device for combined detection of bubbles and flow rate in a system for enriching a bodily fluid with a gas |
US20120129149A1 (en) * | 2009-07-31 | 2012-05-24 | Federspiel William J | Removal of oxygen from biological fluids |
US20130068222A1 (en) * | 2011-06-20 | 2013-03-21 | Klaus Michael SCHMIDT | Anesthetic circuit and a method for using the anesthetic circuit |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE231988C (en) | 1909-08-05 | 1911-03-06 | Device for splitting matches for domestic use | |
DE3142751A1 (en) * | 1980-10-28 | 1982-06-09 | Senko Medical Instrument Mfg. Co., Ltd., Tokyo | Membrane oxygenator |
JPS6183898A (en) * | 1984-10-01 | 1986-04-28 | Mitsubishi Rayon Co Ltd | Heat exchanger |
JPS61128978A (en) * | 1984-11-27 | 1986-06-17 | テルモ株式会社 | Membrane type artificial lung |
US5225161A (en) * | 1988-10-20 | 1993-07-06 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
US5120501A (en) * | 1988-10-20 | 1992-06-09 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
AU7618900A (en) * | 1999-09-30 | 2001-04-23 | Therox, Inc. | Apparatus and method for blood oxygenation |
GB2437254B (en) * | 2006-04-13 | 2010-11-17 | Haemair Ltd | Blood/air mass exchange apparatus |
US7841161B2 (en) | 2007-07-02 | 2010-11-30 | The Hong Kong Polytechnic University | Method of industrially producing yarn at a lower twist multiplier for textile products |
-
2011
- 2011-07-27 DE DE102011052187A patent/DE102011052187A1/en active Pending
-
2012
- 2012-07-27 EP EP12750340.7A patent/EP2736556B1/en active Active
- 2012-07-27 EP EP18196369.5A patent/EP3449959A1/en active Pending
- 2012-07-27 US US14/234,939 patent/US9320844B2/en active Active
- 2012-07-27 WO PCT/EP2012/064801 patent/WO2013014276A1/en active Application Filing
- 2012-07-27 CN CN201280037664.4A patent/CN103842002A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5277176A (en) * | 1992-06-29 | 1994-01-11 | Habashi Nader M | Extracorporeal lung assistance apparatus and process |
US20040057869A1 (en) * | 2000-11-28 | 2004-03-25 | John Dingley | Gas exchange |
US20060231098A1 (en) * | 2002-05-01 | 2006-10-19 | Air Products And Chemicals, Inc. | Medical gas recirculation system |
US20060144235A1 (en) * | 2002-12-02 | 2006-07-06 | Molecular Products Limited | Apparatus and process for carbon dioxide absorption |
US20100143192A1 (en) * | 2008-12-04 | 2010-06-10 | Therox, Inc. | Method and device for combined detection of bubbles and flow rate in a system for enriching a bodily fluid with a gas |
US20120129149A1 (en) * | 2009-07-31 | 2012-05-24 | Federspiel William J | Removal of oxygen from biological fluids |
US20130068222A1 (en) * | 2011-06-20 | 2013-03-21 | Klaus Michael SCHMIDT | Anesthetic circuit and a method for using the anesthetic circuit |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210113755A1 (en) * | 2018-03-02 | 2021-04-22 | Spectrum Medical Ltd. | Oxygenation system |
US20210369931A1 (en) * | 2018-05-22 | 2021-12-02 | Spectrum Medical Ltd | Blood processing system |
WO2023239281A1 (en) * | 2022-06-09 | 2023-12-14 | Maquet Critical Care Ab | Control of carbon dioxide transfer in oxygenator for extracorporeal blood gas exchange |
WO2023239283A1 (en) * | 2022-06-09 | 2023-12-14 | Maquet Critical Care Ab | Multisampling sidestream gas analyser for gas exchange analysis |
Also Published As
Publication number | Publication date |
---|---|
EP2736556B1 (en) | 2018-09-26 |
WO2013014276A1 (en) | 2013-01-31 |
EP2736556A1 (en) | 2014-06-04 |
US9320844B2 (en) | 2016-04-26 |
CN103842002A (en) | 2014-06-04 |
EP3449959A1 (en) | 2019-03-06 |
DE102011052187A1 (en) | 2013-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9320844B2 (en) | Arrangement for removing carbon dioxide from an extracorporeal flow of blood by means of inert gases | |
JP5977786B2 (en) | Nitric oxide generation system | |
JP4563795B2 (en) | Medical gas recirculation system | |
US9408994B2 (en) | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) | |
US4905685A (en) | Inhalation anaesthesia equipment | |
CN107206145B (en) | Ventilation system | |
US20080029091A1 (en) | Method and Device for Administering Xenon to Patients | |
AU2002222107B2 (en) | Gas exchange | |
EP3815729A1 (en) | Anesthesia machine and system | |
US20160346498A1 (en) | Nitric oxide treatment system and method | |
JP2022126656A (en) | O2 concentrator with sieve bed bypass and control method thereof | |
JP4996604B2 (en) | Apparatus and method for providing a gas mixture | |
US20140227134A1 (en) | Electronically controlled gas mixing unit for supplying a purge gas to an oxygenator | |
CN104619370B9 (en) | The anesthesiaing system of the oxygen of patient is delivered to for active control | |
KR20180039373A (en) | Lightweight respiratory apparatus using hollow fiber membrane | |
AU2015202382A1 (en) | Systems for Generating Nitric Oxide |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: MAQUET VERTRIEB UND SERVICE DEUTSCHLAND GMBH, GERM Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JOOST, THILO;KOBRICH, RAINER;REEL/FRAME:032947/0458 Effective date: 20140225 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FEPP | Fee payment procedure |
Free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
AS | Assignment |
Owner name: JOOST, THILO, GERMANY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MAQUET VERTRIEB UND SERVICE DEUTSCHLAND GMBH;REEL/FRAME:052440/0251 Effective date: 20191029 |
|
FEPP | Fee payment procedure |
Free format text: SURCHARGE FOR LATE PAYMENT, SMALL ENTITY (ORIGINAL EVENT CODE: M2554); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY Free format text: ENTITY STATUS SET TO SMALL (ORIGINAL EVENT CODE: SMAL); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY Year of fee payment: 4 |
|
AS | Assignment |
Owner name: HEMOVENT GMBH, GERMANY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:JOOST, THILO;REEL/FRAME:055942/0730 Effective date: 20200825 |
|
FEPP | Fee payment procedure |
Free format text: ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: BIG.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 8TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1552); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY Year of fee payment: 8 |