US20140370073A1 - Biologically degradable compositions for medical applications - Google Patents
Biologically degradable compositions for medical applications Download PDFInfo
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- US20140370073A1 US20140370073A1 US14/475,379 US201414475379A US2014370073A1 US 20140370073 A1 US20140370073 A1 US 20140370073A1 US 201414475379 A US201414475379 A US 201414475379A US 2014370073 A1 US2014370073 A1 US 2014370073A1
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- lactide
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- hydroxybutyrate
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- MBFXSOJEMACPEG-UHFFFAOYSA-N COCC(=O)NCCCCNC(=O)COC(=O)CCCCCCCCC(C)=O Chemical compound COCC(=O)NCCCCNC(=O)COC(=O)CCCCCCCCC(C)=O MBFXSOJEMACPEG-UHFFFAOYSA-N 0.000 description 2
- 0 C*BC Chemical compound C*BC 0.000 description 1
- PYTOFDCAYQKGTF-UHFFFAOYSA-N C.COCCOCCOC(=O)c1ccc(C(=O)OCOC(=O)c2ccc(C(C)=O)cc2)cc1.[H]OCCCCCC(=O)OCCO.[KH] Chemical compound C.COCCOCCOC(=O)c1ccc(C(=O)OCOC(=O)c2ccc(C(C)=O)cc2)cc1.[H]OCCCCCC(=O)OCCO.[KH] PYTOFDCAYQKGTF-UHFFFAOYSA-N 0.000 description 1
- QUSMMWNAUMRFCH-UHFFFAOYSA-N COCCOCCOC(=O)c1ccc(C(=O)OCOC(=O)c2ccc(C(C)=O)cc2)cc1.[KH] Chemical compound COCCOCCOC(=O)c1ccc(C(=O)OCOC(=O)c2ccc(C(C)=O)cc2)cc1.[KH] QUSMMWNAUMRFCH-UHFFFAOYSA-N 0.000 description 1
- WMLOVERDTQGCEB-UHFFFAOYSA-N [H]OCCCCCC(=O)OCCO Chemical compound [H]OCCCCCC(=O)OCCO WMLOVERDTQGCEB-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
Definitions
- This invention is relates to biologically degradable compositions for medical applications such as for coatings for implantable medical devices.
- polymeric materials are being used for a variety of reasons, including making a surface of a device more biocompatible or as a vehicle for delivering a drug. Since polymeric materials are treated as a foreign object by the body's immune system, the challenge has been to make the polymers highly biocompatible as well as to reduce any fouling effects that the polymer may produce or harbor. As a better option, it may be better to make the polymer not only highly biocompatible and non-fouling, but also biodegradable such that the polymer is eliminated by the body after it has served its function.
- the degradation of the polymer should not create any residues that can provide adverse effects for the patient, such as excess inflammation. To the contrary, the products of degradation should enhance the treatment that is being provided to the patient or should provide medicinal effects. Should the polymeric material include a drug for local application, the composition should be capable of carrying the drug so as to release the drug at an efficacious rate for a therapeutically effective duration of time. Finally, if the material is used as a coating, the properties of the composition should be suitable so as to allow a film layer to be formed on the medical device. For devices that include body geometry that expand or fold, such as a stent or a balloon, the polymer must be flexible enough so as to expand or fold with the device without significant detachment or delamination of the coating.
- the embodiments of the present invention provide for biocompatible polymeric compositions that can be used medical applications.
- a medical article comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water.
- the medical article can be a stent, a graft or a stent graft.
- the AB block-copolymer can be capable of absorbing, at equilibrium and at room temperature, about 5 mass % or more water.
- the AB block-copolymer can include a biocompatible polymeric moiety and a structural polymeric moiety.
- the biocompatible polymeric moiety can be, for example, poly(alkylene glycol), poly(2-hydroxyethyl methacrylate), poly(3-hydroxypropyl methacrylamide), hydroxylated poly(vinyl pyrrolidone), sulfonated dextran, sulfonated polystyrene, fibrin, fibrinogen, cellulose, starch, collagen, hyaluronic acid, heparin, a graft copolymer of poly(L-lysine)-graft-co-poly(ethylene glycol), and copolymers thereof.
- the structural polymeric moiety can be poly(D,L-lactide), poly(caprolactone), poly(caprolactone-co-D,L-lactide), poly(butylene terephthalate), poly(ester amide), poly(aspirin), poly(L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), and polydioxanone.
- the second polymer can be poly(L-lactide), poly(D,L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(caprolactone), poly(L-lactide-co-caprolactone), poly(D,L-lactide-co-caprolactone), poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), poly(ester amides), poly(anhydrides), poly(carbonates), poly(trimethylene carbonate-co-glycolide), poly(trimethylene carbonate-co-L-lactide), poly(trimethylene carbonate-co-D,L-lactide), poly(dioxanone), poly(phosphazenes), poly(orthoesters), poly(t
- biologically degradable and “biodegradable” are used interchangeably and refer to polymers that are capable of being completely degraded and/or eroded when exposed to bodily fluids such as blood and can be gradually resorbed, absorbed and/or eliminated by the body.
- the processes of breaking down and eventual absorption and elimination of the polymer can be caused by, for example, hydrolysis, metabolic processes, bulk or surface erosion, and the like.
- coating applications it is understood that after the process of degradation, erosion, absorption, and/or resorption has been completed, no polymer will remain on the device. In some embodiments, very negligible traces or residue may be left behind.
- Biodegradable polymer composition or “biodegradable composition” is defined as a composition having a combination of at least two biologically degradable polymers.
- the composition can also include a non-biologically degradable component or polymer.
- the polymers can be blended, combined, mixed, bonded, linked by linking agent, or conjugated.
- block-copolymer is defined in accordance with the terminology used by the International Union for Pure and Applied Chemistry (IUPAC). “Block-copolymer” refers to a copolymer containing a linear arrangement of blocks. The block is defined as a portion of a polymer molecule in which the monomeric units have at least one constitutional or configurational feature absent from the adjacent portions.
- AB block-copolymer is defined as a block-copolymer having moieties A and B arranged according to the general formula
- each of “m,” “n,” and “x” is a positive integer, and m can be ⁇ 2, and n can be ⁇ 2.
- the blocks of the AB block-copolymers could be, but need not be linked on the ends, since the values of the integers “m” and “n” determining the number of blocks are such as to ensure that the individual blocks are usually long enough to be considered polymers in their own right.
- An AB block copolymer can be, accordingly, named poly A-block-co-poly B block polymer.
- the AB block-copolymer can be part of a chain of another polymer such as in the backbone or as a pendant or side group.
- moiety is defined as a portion of a complete structure of a copolymer, the portion to include at least 2 atoms joined together in a particular way.
- moiety includes functional groups and/or discreet bonded residues that are present in the macromolecule of a copolymer.
- moiety as used in the present application is inclusive of individual units in the copolymers.
- moiety as used in the present application is also inclusive of entire polymeric blocks in the copolymers.
- the biodegradable polymer composition includes at least one biodegradable AB block-copolymer or a polymer that includes biodegradable AB blocks (“the first component”) and at least one other biodegradable polymer (“the second component”).
- the first component can be capable of absorbing, at equilibrium and at room temperature, about 2 mass % or more water, preferably 5 mass % or more water.
- the second component can be capable of absorbing, at equilibrium and at room temperature, less than about 2 mass % water, preferably less than about 5 mass % water.
- the second component is not or does not include an AB polymeric block or can include a polymer that is substantially free of AB polymeric blocks.
- the second component can include a polymer the molecular structure of which is substantially free of fragments shown by formula (I) above.
- the ratio between the first component and the second component in the biodegradable polymer composition can be between about 1:1 and about 1:99, more narrowly, between about 1:2 and about 1:49, for example, about 1:19.
- the First Component (AB Block-Copolymer)
- the AB block copolymer can be capable of absorbing, at equilibrium and at room temperature, about 2 mass %, preferably about 5 mass % or more water.
- AB block copolymers that can be used comprise two polymeric moieties A and B.
- the first polymeric moiety is a biocompatible moiety that can be capable of providing the block-copolymer with blood compatibility.
- the second polymeric moiety is a structural moiety that can be capable of providing the block-copolymer with mechanical and/or adhesive properties.
- the structural moiety allows the copolymer to form a film layer on substrates, such as metallic stents.
- Moiety A can be the biocompatible moiety and moiety B can be the structural moiety.
- Moiety B can be the biocompatible moiety and moiety A can be the structural moiety.
- the mass ratio between be the biocompatible moiety and the structural moiety can be between about 1:9 and about 1:0.7, for example, about 1:0.81.
- the mass ratio 1:0.81 corresponds to an AB block-copolymer comprising about 55 mass % the biocompatible moiety and the balance, the structural moiety.
- the biocompatible and the structural moieties can be selected to make the AB block-copolymers biologically degradable.
- Molecular weight of a biocompatible moiety that can be used can be below 40,000 Daltons, for example, between about 300 and 20,000 Daltons.
- a biocompatible moiety A that can be used is poly(ethylene glycol) (PEG) having the molecular weight between about 300 and 20,000 Daltons.
- PEG poly(ethylene glycol)
- the value of “m” in formula (I) can be between about 5 and about 1,000.
- poly(alkylene glycols) can be used to form the biocompatible moiety, for example, poly(propylene glycol) (PPG), poly(tetramethylene glycol), or poly(ethylene oxide-co-propylene oxide).
- PPG poly(propylene glycol)
- poly(tetramethylene glycol) poly(tetramethylene glycol)
- poly(ethylene oxide-co-propylene oxide) poly(ethylene oxide-co-propylene oxide).
- biocompatible moieties examples include poly(2-hydroxyethyl methacrylate), poly(3-hydroxypropyl methacrylamide), hydroxylated poly(vinyl pyrrolidone), sulfonated dextran, sulfonated polystyrene, fibrin, fibrinogen, cellulose, starch, collagen, hyaluronic acid, heparin, poly(L-lysine)-graft-co-poly(ethylene glycol), which is a graft copolymer of poly(L-lysine) and PEG, or copolymers thereof.
- Molecular weight of a structural moiety that can be used can be between about 20,000 and about 200,000 Daltons, more narrowly, between about 40,000 and about 100,000 Daltons, for example, about 60,000 Daltons.
- a structural moiety B that can be used is poly(D,L-lactide) having the molecular weight between about 20,000 and about 200,000 Daltons.
- the value of “n” in formula (I) can be between about 250 and about 3,000.
- poly(D,L-lactide) In addition to poly(D,L-lactide), other structural moieties can be used. Some examples of such moieties include poly(caprolactone) (PCL), poly(caprolactone-co-D,L-lactide), poly(butylene terephthalate) (PBT), poly(ester amide), poly(aspirin), poly(L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), and polydioxanone.
- PCL poly(caprolactone)
- PBT butylene terephthalate
- PBT butylene terephthalate
- poly(ester amide) poly(
- biodegradable AB block copolymer poly(ethylene-glycol)-block-co-poly(caprolactone) (PEG-PCL).
- PEG-PCL poly(ethylene-glycol)-block-co-poly(caprolactone)
- n are positive integers.
- PEG-PCL block copolymer shown by formula (II) the PEG blocks constitute the biocompatible moiety A, while the PCL block constitutes the structural moiety B.
- Block copolymer shown by formula (II) can be synthesized by standard methods known to those having ordinary skill in the art, for example, copolycondensation of PEG with PCL. The process of copolycondensation can be catalyzed by a catalyst which can be selected by those having ordinary skill in the art, for example, by an acid catalyst or a base catalyst.
- PEG-containing polyester includes a block-copolymer of PEG with PBT, such as poly(ethylene-glycol)-block-poly(butyleneterephthalate) (PEG-PBT), shown by formula (III):
- the PEG-PBT block-copolymer can be obtained by a synthetic process that can be selected by those having ordinary skill in the art.
- One example of the synthetic process that can be used includes trans-esterification of dibutyleneterephthalate with PEG.
- PEG-PBT block copolymer is known under a trade name PolyActiveTM and is available from IsoTis Corp. of Holland.
- the ratio between the PEG units and the PBT units can be between about 0.67:1 and about 9:1.
- the molecular weight of the PEG units can be between about 300 and about 4,000 Daltons.
- PEG-PCL and PEG-PBT block copolymers all contain fragments with ester bonds.
- Ester bonds are known to be water-labile bonds. When in contact with slightly alkaline blood, ester bonds are subject to catalyzed hydrolysis, thus ensuring biological degradability of the block-copolymer.
- One product of degradation of every block polymer, belonging to the group PEG-PCL and PEG-PBT, is expected to be PEG, which is highly biologically compatible.
- PEG also has an additional advantage of being biologically active, reducing smooth muscle cells proliferation at the lesion site and thus capable of treating, delaying, preventing or inhibiting restenosis.
- the second component of the composition can comprise at least one biodegradable polymer capable of absorbing, at equilibrium and at room temperature, less than about 2 mass %, preferably less than 5 mass % water.
- a third component can be included, mixed, blended, bonded, conjugated or linked with the composition.
- This can be a drug, an active agent, or a therapeutic substance.
- another polymer can be included, mixed, blended, bonded, conjugated or linked with the composition. These polymers need not be biodegradable.
- Examples include polyacrylates, such as poly(butyl methacrylate), poly(ethyl methacrylate), and poly(ethyl methacrylate-co-butyl methacrylate), and fluorinated polymers and/or copolymers, such as poly(vinylidene fluoride) and poly(vinylidene fluoride-co-hexafluoro propene), poly(vinyl pyrrolidone), polyurethanes, silicones, polyesters, polyolefins, polyisobutylene and ethylene-alphaolefin copolymers, vinyl halide polymers and copolymers (such as polyvinyl chloride), polyvinyl ethers (such as polyvinyl methyl ether), polyvinylidene chloride, polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics (such as polystyrene), polyvinyl esters (such as polyvinyl acetate), copolymers
- the therapeutic substance can include any substance capable of exerting a therapeutic, diagnostic or prophylactic effect for a patient.
- the therapeutic substance may include small molecule substances, peptides, proteins, oligonucleotides, and the like.
- the therapeutic substance could be designed, for example, to inhibit the activity of vascular smooth muscle cells. It can be directed at inhibiting abnormal or inappropriate migration and/or proliferation of smooth muscle cells to inhibit restenosis.
- therapeutic substances include antiproliferative substances such as actinomycin D, or derivatives and analogs thereof (manufactured by Sigma-Aldrich of Milwaukee, Wis., or COSMEGEN available from Merck). Synonyms of actinomycin D include dactinomycin, actinomycin IV, actinomycin I 1 , actinomycin X 1 , and actinomycin C 1 .
- the active agent can also fall under the genus of antineoplastic, anti-inflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antiallergic and antioxidant substances. Examples of such antineoplastics and/or antimitotics include paclitaxel (e.g.
- TAXOL® by Bristol-Myers Squibb Co., Stamford, Conn.
- docetaxel e.g. Taxotere, from Aventis S.A., Frankfurt, Germany
- methotrexate azathioprine
- vincristine vincristine
- vinblastine a cell line
- fluorouracil a cell line
- doxorubicin hydrochloride e.g. Adriamycin® from Pharmacia & Upjohn, Peapack N.J.
- mitomycin e.g. Mutamycin® from Bristol-Myers Squibb Co., Stamford, Conn.
- antiplatelets examples include sodium heparin, low molecular weight heparins, heparinoids, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogues, dextran, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist antibody, recombinant hirudin, and thrombin inhibitors such as ANGIOMAX (Biogen, Inc., Cambridge, Mass.).
- cytostatic or antiproliferative agents examples include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. Capoten® and Capozide® from Bristol-Myers Squibb Co., Stamford, Conn.), cilazapril or lisinopril (e.g.
- calcium channel blockers such as nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonists, lovastatin (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug, brand name Mevacor® from Merck & Co., Inc., Whitehouse Station, N.J.), monoclonal antibodies (such as those specific for Platelet-Derived Growth Factor (PDGF) receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitors, suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide.
- PDGF Platelet-Derived Growth Factor
- an antiallergic agent is permirolast potassium.
- Other therapeutic substances or agents which may be appropriate include alpha-interferon, genetically engineered epithelial cells, tacrolimus, dexamethasone, and rapamycin and structural derivatives or functional analogs thereof, such as 40-O-(2-hydroxy)ethyl-rapamycin (known by the trade name of EVEROLIMUS available from Novartis), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.
- the composition can have a variety of medical applications, such as coatings for medical devices, coatings for implantable prostheses, capsules for drugs, drug delivery particles as well as devices made at least in part from the composition.
- medical devices that can be used in conjunction with the embodiments of this invention include stents (e.g., self expandable or balloon expandable), biodegradable stents, stent-grafts, grafts (e.g., aortic grafts), catheters, balloons, coating on balloons, guidewires, artificial hearts and valves, blood oxygenerators, ventricular assist devices, cardiopulmonary bypass systems, cerebrospinal fluid shunts, pacemaker electrodes, axius coronary shunts and leads as well as other devices such as intraocular lenses.
- stents e.g., self expandable or balloon expandable
- biodegradable stents e.g., stent-grafts, grafts (e.g., aortic
- the devices can be made from a metallic material or an alloy such as, but not limited to, cobalt-chromium alloys (e.g., ELGILOY), stainless steel (316L), “MP35N,” “MP20N,” ELASTINITE (Nitinol), tantalum, tantalum-based alloys, nickel-titanium alloy, platinum, platinum-based alloys such as, e.g., platinum-iridium alloy, iridium, gold, magnesium, titanium, titanium-based alloys, zirconium-based alloys, or combinations thereof.
- Devices made from bioabsorbable or biostable polymers can also be used or coated with the embodiments of the present invention.
- MP35N and MP20N are trade names for alloys of cobalt, nickel, chromium and molybdenum available from Standard Press Steel Co. of Jenkintown, Pa. “MP35N” consists of 35% cobalt, 35% nickel, 20% chromium, and 10% molybdenum. “MP20N” consists of 50% cobalt, 20% nickel, 20% chromium, and 10% molybdenum.
- a coating for a stent made from the composition of the present invention can be a multi-layer structure and can include a primer layer; a drug-polymer layer (also referred to as “reservoir” or “reservoir layer”) or alternatively a polymer free drug layer; and/or a topcoat layer. Intermediary layers can also be provided.
- Each layer of the stent coating can be formed on the stent by dissolving the biodegradable polymer composition in a solvent, or a mixture of solvents, and applying the resulting solution on the stent by spraying or immersing the stent in the solution. At least one of the layers should include the bidegradable polymeric composition of the present invention.
- the remaining portion of a layer or the other layers can be made from other polymeric material, such as poly(butyl methacrylate), poly(ethyl methacrylate), and poly(ethyl methacrylate-co-butyl methacrylate), or the others disclosed above.
- the outer most layer (e.g., the reservoir layer or the topcoat layer) is made from the biodegradable composition.
- the topcoat layer can be made from the biodegradable polymer.
- the reservoir layer or the optional primer layer can be made from the same composition, the same composition but with different ratios of the first to second component, the same composition but with different ratios of the first to second to third component or from a different polymeric material.
- At least two of the layers can be made from the embodiments of the biodegradable polymeric composition such that for each layer the ratio of the first to second component is different. In some embodiments, if a third component is used, the ratio of the first to second to third component can be different for each layer.
- the coating is dried by allowing the solvent to evaporate.
- the process of drying can be accelerated if the drying is conducted at an elevated temperature.
- solvents suitable for making the coating solution include N,N-dimethylacetamide (DMAC), N,N-dimethylformamide (DMF), tethrahydrofurane (THF), cyclohexanone, xylene, toluene, acetone, i-propanol, methyl ethyl ketone, propylene glycol monomethyl ether, methyl butyl ketone, ethyl acetate, n-butyl acetate, and dioxane.
- DMAC N,N-dimethylacetamide
- DMF N,N-dimethylformamide
- THF tethrahydrofurane
- cyclohexanone cyclohexanone
- xylene toluene
- acetone i-propanol
- methyl ethyl ketone propylene glycol monomethyl ether
- methyl butyl ketone ethy
- mixtures include DMAC and methanol (e.g., a 50:50 by mass mixture); water, i-propanol, and DMAC (e.g., a 10:3:87 by mass mixture); i-propanol and DMAC (e.g., 80:20, 50:50, or 20:80 by mass mixtures); acetone and cyclohexanone (e.g., 80:20, 50:50, or 20:80 by mass mixtures); acetone and xylene (e.g.
- FLUX REMOVER AMS is trade name of a solvent manufactured by Tech Spray, Inc. of Amarillo, Tex. comprising about 93.7% of a mixture of 3,3-dichloro-1,1,1,2,2-pentafluoropropane and 1,3-dichloro-1,1,2,2,3-pentafluoropropane, and the balance of methanol, with trace amounts of nitromethane.
- the drug in a form of a solution can be combined with the polymer solution that is applied onto the stent as described above.
- the drug can be dissolved in a suitable solvent or mixture of solvents, and the resulting drug solution can be applied on the stent by spraying or immersing the stent in the drug solution.
- the drug can be introduced as a colloid system, such as a suspension in an appropriate solvent phase. To make the suspension, the drug can be dispersed in the solvent phase using conventional techniques used in colloid or emulsion chemistry.
- the suitable solvent to form the solvent phase of the suspension can be selected as well as the quantity of the drug to be dispersed in the solvent phase.
- the suspension can be mixed with a polymer solution and the mixture can be applied on the stent as described above.
- the drug suspension can be applied on the stent without being mixed with the polymer solution.
- the biological degradation of the biodegradable polymer composition is expected to cause an increase of the rate of release of the drug due to the gradual disappearance of the polymer that forms the reservoir and/or the topcoat layer.
- a coating of the various described embodiments can be formed on an implantable device or prosthesis, e.g., a stent.
- the agent will be retain on the medical device such as a stent during delivery and expansion of the device, and released at a desired rate and for a predetermined duration of time at the site of implantation.
- the medical device is a stent.
- a stent having the above-described coating is useful for a variety of medical procedures, including, by way of example, treatment of obstructions caused by tumors in bile ducts, esophagus, trachea/bronchi and other biological passageways.
- a stent having the above-described coating is particularly useful for treating occluded regions of blood vessels caused by abnormal or inappropriate migration and proliferation of smooth muscle cells, thrombosis, and restenosis.
- Stents may be placed in a wide array of blood vessels, both arteries and veins. Representative examples of sites include the iliac, renal, and coronary arteries.
- compositions of the invention can be used for the treatment of a variety of disorder in mammals including atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, cancer as well as other disorders.
- an angiogram is first performed to determine the appropriate positioning for stent therapy.
- An angiogram is typically accomplished by injecting a radiopaque contrasting agent through a catheter inserted into an artery or vein as an x-ray is taken.
- a guidewire is then advanced through the lesion or proposed site of treatment.
- Over the guidewire is passed a delivery catheter which allows a stent in its collapsed configuration to be inserted into the passageway.
- the delivery catheter is inserted either percutaneously or by surgery into the femoral artery, brachial artery, femoral vein, or brachial vein, and advanced into the appropriate blood vessel by steering the catheter through the vascular system under fluoroscopic guidance.
- a stent having the above-described coating may then be expanded at the desired area of treatment.
- a post-insertion angiogram may also be utilized to confirm appropriate positioning.
- a first composition can be prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % poly(caprolactone) (PCL); and the balance, mixture of tetrahydrofuran (THF) and xylene solvents, where a mass ratio between THF and xylene was about 3:1.
- the first composition can be applied onto the surface of a bare 12 mm VISION stent (available from Guidant Corporation) by spraying and dried to form a primer layer.
- a spray coater was used, having a 0.014 fan nozzle maintained at about 60° C. with a feed pressure of about 0.2 atm (about 3 psi) and an atomization pressure of about 1.3 atm (about 20 psi). About 75 ⁇ g of the wet coating can be applied.
- the primer was baked at about 60° C. for about 2 hours, yielding a dry primer layer.
- a second composition can be prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % PCL; about 0.05 mass % to about 2.0 mass %, for example, about 1.0 mass % EVEROLIMUS; and the balance, THF/xylene solvent mixture described above.
- the second composition can contain about 300 ⁇ g PCL and about 150 ⁇ g EVEROLIMUS.
- the second composition can be applied onto the dried primer layer to form the reservoir layer, using the same spraying technique and equipment used for applying the primer layer, followed by drying, e.g., by baking at about 50° C. for about 1 hour.
- a third composition can prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % PCL; about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % PEG-PBT (4000PEGT80PBT20); and the balance, THF/xylene solvent mixture described above.
- the brand of PEG-PBT that can be used can have about 20 molar % PBT units and about 80 molar % PEG units. The molecular weight of the PEG units was about 4,000 Daltons.
- the third composition can contain about 50 ⁇ g PCL and about 50 ⁇ g PEG-PBT. The third composition can be applied onto the dried reservoir layer to form a topcoat layer, using the same spraying technique and equipment used for applying the primer layer and the reservoir layer, followed by drying at about 50° C. for about 1 hour.
- a primer and reservoir layers can be formed on a stent as described in Example 1.
- a composition can be prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % poly(L-lactide); about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % PEG-PBT; and the balance, the mixture of chloroform and tricholoethane solvents, wherein the mass ratio between chloroform and trichlorethane can be about 1:1.
- the same brand of PEG-PBT as described in Example 1 can be used.
- the composition can contain about 60 ⁇ g poly(L-lactide), about 40 ⁇ g PEG-PBT, and if desired, about 200 ⁇ g paclitaxel.
- the composition can be applied onto the dried reservoir layer to form a topcoat layer.
- a primer and reservoir layers can be formed on a stent as described in Example 1, except rapamycin can be used instead of EVEROLIMUS.
- a composition can be prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 1.5 mass % poly(ester amide); about 1.0 mass % to about 15 mass %, for example, about 0.5 mass % PEG-PBT; and the balance, a mixture of ethanol and DMAC solvents, wherein mass ratio between ethanol and DMAC can be about 1:1.
- n is a positive integer
- the composition can contain about 75 ⁇ g poly(ester amide), and about 25 ⁇ g PEG-PBT.
- the composition can be applied onto the dried reservoir layer to form a topcoat layer, using the same spraying technique and equipment as described above, followed by drying, e.g., by baking.
- the poly(ester amide) shown by formula (IV) is expected to degrade when exposed to bodily fluids such as blood to yield sebacic and glycolic acids and 1,4-butanediamine (putrescine), all of which are biocompatible.
Abstract
A medical article is disclosed, comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water.
Description
- This application is a divisional application of application Ser. No. 12/182,066 filed Jul. 29, 2008, which is a continuation of application Ser. No. 10/812,780, filed 29 Mar. 2004, which applications are incorporated by reference in their entirety, including any drawings, as if fully set forth herein.
- 1. Field of the Invention
- This invention is relates to biologically degradable compositions for medical applications such as for coatings for implantable medical devices.
- 2. Description of the State of the Art
- A wide spectrum of devices, from vascular devices such as catheters, stents, and guidewires, to ocular devices such as intra-ocular lenses is incorporating polymeric material. Polymeric materials are being used for a variety of reasons, including making a surface of a device more biocompatible or as a vehicle for delivering a drug. Since polymeric materials are treated as a foreign object by the body's immune system, the challenge has been to make the polymers highly biocompatible as well as to reduce any fouling effects that the polymer may produce or harbor. As a better option, it may be better to make the polymer not only highly biocompatible and non-fouling, but also biodegradable such that the polymer is eliminated by the body after it has served its function. The degradation of the polymer should not create any residues that can provide adverse effects for the patient, such as excess inflammation. To the contrary, the products of degradation should enhance the treatment that is being provided to the patient or should provide medicinal effects. Should the polymeric material include a drug for local application, the composition should be capable of carrying the drug so as to release the drug at an efficacious rate for a therapeutically effective duration of time. Finally, if the material is used as a coating, the properties of the composition should be suitable so as to allow a film layer to be formed on the medical device. For devices that include body geometry that expand or fold, such as a stent or a balloon, the polymer must be flexible enough so as to expand or fold with the device without significant detachment or delamination of the coating. Tradeoffs do exist between biocompatibility, structural integrity and drug delivery capabilities of the polymer. Enhancing one characteristic may determinately affect the other. Accordingly, a proper balance must be drawn to provide for a polymeric composition that meets the specific need of the application for which it is being used.
- The embodiments of the present invention provide for biocompatible polymeric compositions that can be used medical applications.
- A medical article is provided comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water. The medical article can be a stent, a graft or a stent graft. The AB block-copolymer can be capable of absorbing, at equilibrium and at room temperature, about 5 mass % or more water. The AB block-copolymer can include a biocompatible polymeric moiety and a structural polymeric moiety. The biocompatible polymeric moiety can be, for example, poly(alkylene glycol), poly(2-hydroxyethyl methacrylate), poly(3-hydroxypropyl methacrylamide), hydroxylated poly(vinyl pyrrolidone), sulfonated dextran, sulfonated polystyrene, fibrin, fibrinogen, cellulose, starch, collagen, hyaluronic acid, heparin, a graft copolymer of poly(L-lysine)-graft-co-poly(ethylene glycol), and copolymers thereof. The structural polymeric moiety can be poly(D,L-lactide), poly(caprolactone), poly(caprolactone-co-D,L-lactide), poly(butylene terephthalate), poly(ester amide), poly(aspirin), poly(L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), and polydioxanone. The second polymer can be poly(L-lactide), poly(D,L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(caprolactone), poly(L-lactide-co-caprolactone), poly(D,L-lactide-co-caprolactone), poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), poly(ester amides), poly(anhydrides), poly(carbonates), poly(trimethylene carbonate-co-glycolide), poly(trimethylene carbonate-co-L-lactide), poly(trimethylene carbonate-co-D,L-lactide), poly(dioxanone), poly(phosphazenes), poly(orthoesters), poly(tyrosine-co-carbonates), polyalkylene oxalates, poly(glycerol-co-sebacic acid esters), cyanoacrylates, poly(amino acids), poly(lysine), poly(glutamic acid) and combinations thereof.
- For the purposes of the present invention, the following terms and definitions apply:
- The terms “biologically degradable” and “biodegradable” are used interchangeably and refer to polymers that are capable of being completely degraded and/or eroded when exposed to bodily fluids such as blood and can be gradually resorbed, absorbed and/or eliminated by the body. The processes of breaking down and eventual absorption and elimination of the polymer can be caused by, for example, hydrolysis, metabolic processes, bulk or surface erosion, and the like. For coating applications, it is understood that after the process of degradation, erosion, absorption, and/or resorption has been completed, no polymer will remain on the device. In some embodiments, very negligible traces or residue may be left behind. Whenever the terms “degradable,” “biodegradable,” or “biologically degradable” are used in this application, they are intended to broadly include biologically erodable, bioabsorbable, and bioresorbable polymers as well as other types of polymers that are broken down and/or eliminated by the body.
- “Biodegradable polymer composition” or “biodegradable composition” is defined as a composition having a combination of at least two biologically degradable polymers. In some embodiments, the composition can also include a non-biologically degradable component or polymer. The polymers can be blended, combined, mixed, bonded, linked by linking agent, or conjugated.
- The term “block-copolymer” is defined in accordance with the terminology used by the International Union for Pure and Applied Chemistry (IUPAC). “Block-copolymer” refers to a copolymer containing a linear arrangement of blocks. The block is defined as a portion of a polymer molecule in which the monomeric units have at least one constitutional or configurational feature absent from the adjacent portions. The term “AB block-copolymer” is defined as a block-copolymer having moieties A and B arranged according to the general formula
- where each of “m,” “n,” and “x” is a positive integer, and m can be ≧2, and n can be ≧2. The blocks of the AB block-copolymers, could be, but need not be linked on the ends, since the values of the integers “m” and “n” determining the number of blocks are such as to ensure that the individual blocks are usually long enough to be considered polymers in their own right. An AB block copolymer can be, accordingly, named poly A-block-co-poly B block polymer. In some embodiments, the AB block-copolymer can be part of a chain of another polymer such as in the backbone or as a pendant or side group.
- The term “moiety” is defined as a portion of a complete structure of a copolymer, the portion to include at least 2 atoms joined together in a particular way. The term “moiety” includes functional groups and/or discreet bonded residues that are present in the macromolecule of a copolymer. The term “moiety” as used in the present application is inclusive of individual units in the copolymers. The term “moiety” as used in the present application is also inclusive of entire polymeric blocks in the copolymers.
- The biodegradable polymer composition includes at least one biodegradable AB block-copolymer or a polymer that includes biodegradable AB blocks (“the first component”) and at least one other biodegradable polymer (“the second component”). The first component can be capable of absorbing, at equilibrium and at room temperature, about 2 mass % or more water, preferably 5 mass % or more water. The second component can be capable of absorbing, at equilibrium and at room temperature, less than about 2 mass % water, preferably less than about 5 mass % water. The second component is not or does not include an AB polymeric block or can include a polymer that is substantially free of AB polymeric blocks. In other words, the second component can include a polymer the molecular structure of which is substantially free of fragments shown by formula (I) above. The ratio between the first component and the second component in the biodegradable polymer composition can be between about 1:1 and about 1:99, more narrowly, between about 1:2 and about 1:49, for example, about 1:19.
- The AB block copolymer can be capable of absorbing, at equilibrium and at room temperature, about 2 mass %, preferably about 5 mass % or more water. AB block copolymers that can be used comprise two polymeric moieties A and B. The first polymeric moiety is a biocompatible moiety that can be capable of providing the block-copolymer with blood compatibility. The second polymeric moiety is a structural moiety that can be capable of providing the block-copolymer with mechanical and/or adhesive properties. The structural moiety allows the copolymer to form a film layer on substrates, such as metallic stents. Moiety A can be the biocompatible moiety and moiety B can be the structural moiety. In some embodiments, Moiety B can be the biocompatible moiety and moiety A can be the structural moiety. The mass ratio between be the biocompatible moiety and the structural moiety can be between about 1:9 and about 1:0.7, for example, about 1:0.81. The mass ratio 1:0.81 corresponds to an AB block-copolymer comprising about 55 mass % the biocompatible moiety and the balance, the structural moiety.
- The biocompatible and the structural moieties can be selected to make the AB block-copolymers biologically degradable. Molecular weight of a biocompatible moiety that can be used can be below 40,000 Daltons, for example, between about 300 and 20,000 Daltons. To illustrate, one example of a biocompatible moiety A that can be used is poly(ethylene glycol) (PEG) having the molecular weight between about 300 and 20,000 Daltons. In this example (when the A moiety is PEG), the value of “m” in formula (I) can be between about 5 and about 1,000.
- In addition to PEG, other poly(alkylene glycols) can be used to form the biocompatible moiety, for example, poly(propylene glycol) (PPG), poly(tetramethylene glycol), or poly(ethylene oxide-co-propylene oxide). Examples of other biocompatible moieties that can be used include poly(2-hydroxyethyl methacrylate), poly(3-hydroxypropyl methacrylamide), hydroxylated poly(vinyl pyrrolidone), sulfonated dextran, sulfonated polystyrene, fibrin, fibrinogen, cellulose, starch, collagen, hyaluronic acid, heparin, poly(L-lysine)-graft-co-poly(ethylene glycol), which is a graft copolymer of poly(L-lysine) and PEG, or copolymers thereof.
- Molecular weight of a structural moiety that can be used can be between about 20,000 and about 200,000 Daltons, more narrowly, between about 40,000 and about 100,000 Daltons, for example, about 60,000 Daltons. To illustrate, one example of a structural moiety B that can be used is poly(D,L-lactide) having the molecular weight between about 20,000 and about 200,000 Daltons. In this example, the value of “n” in formula (I) can be between about 250 and about 3,000.
- In addition to poly(D,L-lactide), other structural moieties can be used. Some examples of such moieties include poly(caprolactone) (PCL), poly(caprolactone-co-D,L-lactide), poly(butylene terephthalate) (PBT), poly(ester amide), poly(aspirin), poly(L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), and polydioxanone.
- One example of the biodegradable AB block copolymer is poly(ethylene-glycol)-block-co-poly(caprolactone) (PEG-PCL). One possible structure of the PEG-PCL block copolymer can be illustrated by formula (II):
- wherein m are n are positive integers.
- In PEG-PCL block copolymer shown by formula (II), the PEG blocks constitute the biocompatible moiety A, while the PCL block constitutes the structural moiety B. Block copolymer shown by formula (II) can be synthesized by standard methods known to those having ordinary skill in the art, for example, copolycondensation of PEG with PCL. The process of copolycondensation can be catalyzed by a catalyst which can be selected by those having ordinary skill in the art, for example, by an acid catalyst or a base catalyst.
- Another example of the PEG-containing polyester includes a block-copolymer of PEG with PBT, such as poly(ethylene-glycol)-block-poly(butyleneterephthalate) (PEG-PBT), shown by formula (III):
- wherein m, n, I and K are positive integers.
- The PEG-PBT block-copolymer can be obtained by a synthetic process that can be selected by those having ordinary skill in the art. One example of the synthetic process that can be used includes trans-esterification of dibutyleneterephthalate with PEG. One brand of PEG-PBT block copolymer is known under a trade name PolyActive™ and is available from IsoTis Corp. of Holland. In PEG-PBT, the ratio between the PEG units and the PBT units can be between about 0.67:1 and about 9:1. The molecular weight of the PEG units can be between about 300 and about 4,000 Daltons.
- PEG-PCL and PEG-PBT block copolymers all contain fragments with ester bonds. Ester bonds are known to be water-labile bonds. When in contact with slightly alkaline blood, ester bonds are subject to catalyzed hydrolysis, thus ensuring biological degradability of the block-copolymer. One product of degradation of every block polymer, belonging to the group PEG-PCL and PEG-PBT, is expected to be PEG, which is highly biologically compatible. PEG also has an additional advantage of being biologically active, reducing smooth muscle cells proliferation at the lesion site and thus capable of treating, delaying, preventing or inhibiting restenosis.
- The second component of the composition can comprise at least one biodegradable polymer capable of absorbing, at equilibrium and at room temperature, less than about 2 mass %, preferably less than 5 mass % water.
- Examples of suitable biodegradable polymers that can be used as a second component of the biodegradable polymer composition include poly(L-lactide), poly(D,L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(caprolactone), poly(L-lactide-co-caprolactone), poly(D,L-lactide-co-caprolactone), polyhydroxyalkanoates, poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), poly(ester amides), poly(anhydrides), poly(carbonates), poly(trimethylene carbonate-co-glycolide), poly(trimethylene carbonate-co-L-lactide), poly(trimethylene carbonate-co-D,L-lactide), poly(dioxanone), poly(phosphazenes), poly(orthoesters), poly(tyrosine-co-carbonates), polyalkylene oxalates, poly(glycerol-co-sebacic acid esters), cyanoacrylates, poly(amino acids), poly(lysine), poly(glutamic acid) and mixtures thereof.
- In some embodiments, a third component can be included, mixed, blended, bonded, conjugated or linked with the composition. This can be a drug, an active agent, or a therapeutic substance. In some embodiments, another polymer can be included, mixed, blended, bonded, conjugated or linked with the composition. These polymers need not be biodegradable. Examples include polyacrylates, such as poly(butyl methacrylate), poly(ethyl methacrylate), and poly(ethyl methacrylate-co-butyl methacrylate), and fluorinated polymers and/or copolymers, such as poly(vinylidene fluoride) and poly(vinylidene fluoride-co-hexafluoro propene), poly(vinyl pyrrolidone), polyurethanes, silicones, polyesters, polyolefins, polyisobutylene and ethylene-alphaolefin copolymers, vinyl halide polymers and copolymers (such as polyvinyl chloride), polyvinyl ethers (such as polyvinyl methyl ether), polyvinylidene chloride, polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics (such as polystyrene), polyvinyl esters (such as polyvinyl acetate), copolymers of vinyl monomers with each other and olefins, e.g., poly(ethylene-co-vinyl alcohol) (EVAL), ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers, polyamides (such as Nylon 66 and polycaprolactam), alkyd resins, polyoxymethylenes, polyimides, polyethers, epoxy resins, rayon, rayon-triacetate, cellulose, cellulose acetate, cellulose butyrate, cellulose acetate butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, and carboxymethyl cellulose.
- The therapeutic substance can include any substance capable of exerting a therapeutic, diagnostic or prophylactic effect for a patient. The therapeutic substance may include small molecule substances, peptides, proteins, oligonucleotides, and the like. The therapeutic substance could be designed, for example, to inhibit the activity of vascular smooth muscle cells. It can be directed at inhibiting abnormal or inappropriate migration and/or proliferation of smooth muscle cells to inhibit restenosis.
- Examples of therapeutic substances include antiproliferative substances such as actinomycin D, or derivatives and analogs thereof (manufactured by Sigma-Aldrich of Milwaukee, Wis., or COSMEGEN available from Merck). Synonyms of actinomycin D include dactinomycin, actinomycin IV, actinomycin I1, actinomycin X1, and actinomycin C1. The active agent can also fall under the genus of antineoplastic, anti-inflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antiallergic and antioxidant substances. Examples of such antineoplastics and/or antimitotics include paclitaxel (e.g. TAXOL® by Bristol-Myers Squibb Co., Stamford, Conn.), docetaxel (e.g. Taxotere, from Aventis S.A., Frankfurt, Germany) methotrexate, azathioprine, vincristine, vinblastine, fluorouracil, doxorubicin hydrochloride (e.g. Adriamycin® from Pharmacia & Upjohn, Peapack N.J.), and mitomycin (e.g. Mutamycin® from Bristol-Myers Squibb Co., Stamford, Conn.). Examples of such antiplatelets, anticoagulants, antifibrin, and antithrombins include sodium heparin, low molecular weight heparins, heparinoids, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogues, dextran, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist antibody, recombinant hirudin, and thrombin inhibitors such as ANGIOMAX (Biogen, Inc., Cambridge, Mass.). Examples of such cytostatic or antiproliferative agents include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. Capoten® and Capozide® from Bristol-Myers Squibb Co., Stamford, Conn.), cilazapril or lisinopril (e.g. Prinivil® and Prinzide® from Merck & Co., Inc., Whitehouse Station, N.J.); calcium channel blockers (such as nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonists, lovastatin (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug, brand name Mevacor® from Merck & Co., Inc., Whitehouse Station, N.J.), monoclonal antibodies (such as those specific for Platelet-Derived Growth Factor (PDGF) receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitors, suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An example of an antiallergic agent is permirolast potassium. Other therapeutic substances or agents which may be appropriate include alpha-interferon, genetically engineered epithelial cells, tacrolimus, dexamethasone, and rapamycin and structural derivatives or functional analogs thereof, such as 40-O-(2-hydroxy)ethyl-rapamycin (known by the trade name of EVEROLIMUS available from Novartis), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, prodrugs thereof, co-drugs thereof, and combinations thereof.
- The composition can have a variety of medical applications, such as coatings for medical devices, coatings for implantable prostheses, capsules for drugs, drug delivery particles as well as devices made at least in part from the composition. Examples of medical devices, that can be used in conjunction with the embodiments of this invention include stents (e.g., self expandable or balloon expandable), biodegradable stents, stent-grafts, grafts (e.g., aortic grafts), catheters, balloons, coating on balloons, guidewires, artificial hearts and valves, blood oxygenerators, ventricular assist devices, cardiopulmonary bypass systems, cerebrospinal fluid shunts, pacemaker electrodes, axius coronary shunts and leads as well as other devices such as intraocular lenses. The devices, e.g., the stent, can be made from a metallic material or an alloy such as, but not limited to, cobalt-chromium alloys (e.g., ELGILOY), stainless steel (316L), “MP35N,” “MP20N,” ELASTINITE (Nitinol), tantalum, tantalum-based alloys, nickel-titanium alloy, platinum, platinum-based alloys such as, e.g., platinum-iridium alloy, iridium, gold, magnesium, titanium, titanium-based alloys, zirconium-based alloys, or combinations thereof. Devices made from bioabsorbable or biostable polymers can also be used or coated with the embodiments of the present invention. “MP35N” and “MP20N” are trade names for alloys of cobalt, nickel, chromium and molybdenum available from Standard Press Steel Co. of Jenkintown, Pa. “MP35N” consists of 35% cobalt, 35% nickel, 20% chromium, and 10% molybdenum. “MP20N” consists of 50% cobalt, 20% nickel, 20% chromium, and 10% molybdenum.
- A coating for a stent made from the composition of the present invention can be a multi-layer structure and can include a primer layer; a drug-polymer layer (also referred to as “reservoir” or “reservoir layer”) or alternatively a polymer free drug layer; and/or a topcoat layer. Intermediary layers can also be provided. Each layer of the stent coating can be formed on the stent by dissolving the biodegradable polymer composition in a solvent, or a mixture of solvents, and applying the resulting solution on the stent by spraying or immersing the stent in the solution. At least one of the layers should include the bidegradable polymeric composition of the present invention. The remaining portion of a layer or the other layers can be made from other polymeric material, such as poly(butyl methacrylate), poly(ethyl methacrylate), and poly(ethyl methacrylate-co-butyl methacrylate), or the others disclosed above.
- Preferably, the outer most layer (e.g., the reservoir layer or the topcoat layer) is made from the biodegradable composition. If a topcoat layer is used, the topcoat layer can be made from the biodegradable polymer. The reservoir layer or the optional primer layer can be made from the same composition, the same composition but with different ratios of the first to second component, the same composition but with different ratios of the first to second to third component or from a different polymeric material.
- In some embodiments at least two of the layers can be made from the embodiments of the biodegradable polymeric composition such that for each layer the ratio of the first to second component is different. In some embodiments, if a third component is used, the ratio of the first to second to third component can be different for each layer.
- After the solution has been applied onto the stent, the coating is dried by allowing the solvent to evaporate. The process of drying can be accelerated if the drying is conducted at an elevated temperature.
- Representative examples of some solvents suitable for making the coating solution include N,N-dimethylacetamide (DMAC), N,N-dimethylformamide (DMF), tethrahydrofurane (THF), cyclohexanone, xylene, toluene, acetone, i-propanol, methyl ethyl ketone, propylene glycol monomethyl ether, methyl butyl ketone, ethyl acetate, n-butyl acetate, and dioxane. Some solvent mixtures can be used as well. Representative examples of the mixtures include DMAC and methanol (e.g., a 50:50 by mass mixture); water, i-propanol, and DMAC (e.g., a 10:3:87 by mass mixture); i-propanol and DMAC (e.g., 80:20, 50:50, or 20:80 by mass mixtures); acetone and cyclohexanone (e.g., 80:20, 50:50, or 20:80 by mass mixtures); acetone and xylene (e.g. a 50:50 by mass mixture); acetone, FLUX REMOVER AMS, and xylene (e.g., a 10:50:40 by mass mixture); and 1,1,2-trichloroethane and chloroform (e.g., a 80:20 by mass mixture). FLUX REMOVER AMS is trade name of a solvent manufactured by Tech Spray, Inc. of Amarillo, Tex. comprising about 93.7% of a mixture of 3,3-dichloro-1,1,1,2,2-pentafluoropropane and 1,3-dichloro-1,1,2,2,3-pentafluoropropane, and the balance of methanol, with trace amounts of nitromethane. Those having ordinary skill in the art will select the solvent or a mixture of solvents suitable for a particular polymer being dissolved.
- To incorporate a drug into the reservoir layer, the drug in a form of a solution can be combined with the polymer solution that is applied onto the stent as described above. Alternatively, to fabricate a polymer free drug layer, the drug can be dissolved in a suitable solvent or mixture of solvents, and the resulting drug solution can be applied on the stent by spraying or immersing the stent in the drug solution. Instead of introducing the drug in a solution, the drug can be introduced as a colloid system, such as a suspension in an appropriate solvent phase. To make the suspension, the drug can be dispersed in the solvent phase using conventional techniques used in colloid or emulsion chemistry. Depending on a variety of factors, e.g., the nature of the drug, those having ordinary skill in the art can select the suitable solvent to form the solvent phase of the suspension, as well as the quantity of the drug to be dispersed in the solvent phase. The suspension can be mixed with a polymer solution and the mixture can be applied on the stent as described above. Alternatively, the drug suspension can be applied on the stent without being mixed with the polymer solution.
- The biological degradation of the biodegradable polymer composition is expected to cause an increase of the rate of release of the drug due to the gradual disappearance of the polymer that forms the reservoir and/or the topcoat layer. By choosing an appropriate biodegradable polymer composition or by varying the ratio of the components of the composition, or by including a third polymeric component to the matrix, a stent coating having a costumed release rate can be engineered.
- In accordance with embodiments of the invention, a coating of the various described embodiments can be formed on an implantable device or prosthesis, e.g., a stent. For coatings including one or more active agents, the agent will be retain on the medical device such as a stent during delivery and expansion of the device, and released at a desired rate and for a predetermined duration of time at the site of implantation. Preferably, the medical device is a stent. A stent having the above-described coating is useful for a variety of medical procedures, including, by way of example, treatment of obstructions caused by tumors in bile ducts, esophagus, trachea/bronchi and other biological passageways. A stent having the above-described coating is particularly useful for treating occluded regions of blood vessels caused by abnormal or inappropriate migration and proliferation of smooth muscle cells, thrombosis, and restenosis. Stents may be placed in a wide array of blood vessels, both arteries and veins. Representative examples of sites include the iliac, renal, and coronary arteries.
- The compositions of the invention can be used for the treatment of a variety of disorder in mammals including atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, cancer as well as other disorders.
- For implantation of a stent, an angiogram is first performed to determine the appropriate positioning for stent therapy. An angiogram is typically accomplished by injecting a radiopaque contrasting agent through a catheter inserted into an artery or vein as an x-ray is taken. A guidewire is then advanced through the lesion or proposed site of treatment. Over the guidewire is passed a delivery catheter which allows a stent in its collapsed configuration to be inserted into the passageway. The delivery catheter is inserted either percutaneously or by surgery into the femoral artery, brachial artery, femoral vein, or brachial vein, and advanced into the appropriate blood vessel by steering the catheter through the vascular system under fluoroscopic guidance. A stent having the above-described coating may then be expanded at the desired area of treatment. A post-insertion angiogram may also be utilized to confirm appropriate positioning.
- The following examples are provided to further illustrate embodiments of the present invention.
- A first composition can be prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % poly(caprolactone) (PCL); and the balance, mixture of tetrahydrofuran (THF) and xylene solvents, where a mass ratio between THF and xylene was about 3:1. The first composition can be applied onto the surface of a bare 12 mm VISION stent (available from Guidant Corporation) by spraying and dried to form a primer layer. A spray coater was used, having a 0.014 fan nozzle maintained at about 60° C. with a feed pressure of about 0.2 atm (about 3 psi) and an atomization pressure of about 1.3 atm (about 20 psi). About 75 μg of the wet coating can be applied. The primer was baked at about 60° C. for about 2 hours, yielding a dry primer layer.
- A second composition can be prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % PCL; about 0.05 mass % to about 2.0 mass %, for example, about 1.0 mass % EVEROLIMUS; and the balance, THF/xylene solvent mixture described above. The second composition can contain about 300 μg PCL and about 150 μg EVEROLIMUS. The second composition can be applied onto the dried primer layer to form the reservoir layer, using the same spraying technique and equipment used for applying the primer layer, followed by drying, e.g., by baking at about 50° C. for about 1 hour. A third composition can prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % PCL; about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % PEG-PBT (4000PEGT80PBT20); and the balance, THF/xylene solvent mixture described above.
- The brand of PEG-PBT that can be used can have about 20 molar % PBT units and about 80 molar % PEG units. The molecular weight of the PEG units was about 4,000 Daltons. The third composition can contain about 50 μg PCL and about 50 μg PEG-PBT. The third composition can be applied onto the dried reservoir layer to form a topcoat layer, using the same spraying technique and equipment used for applying the primer layer and the reservoir layer, followed by drying at about 50° C. for about 1 hour.
- A primer and reservoir layers can be formed on a stent as described in Example 1. A composition can be prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % poly(L-lactide); about 1.0 mass % to about 15 mass %, for example, about 2.0 mass % PEG-PBT; and the balance, the mixture of chloroform and tricholoethane solvents, wherein the mass ratio between chloroform and trichlorethane can be about 1:1. The same brand of PEG-PBT as described in Example 1 can be used. The composition can contain about 60 μg poly(L-lactide), about 40 μg PEG-PBT, and if desired, about 200 μg paclitaxel. The composition can be applied onto the dried reservoir layer to form a topcoat layer.
- A primer and reservoir layers can be formed on a stent as described in Example 1, except rapamycin can be used instead of EVEROLIMUS. A composition can be prepared by mixing about 1.0 mass % to about 15 mass %, for example, about 1.5 mass % poly(ester amide); about 1.0 mass % to about 15 mass %, for example, about 0.5 mass % PEG-PBT; and the balance, a mixture of ethanol and DMAC solvents, wherein mass ratio between ethanol and DMAC can be about 1:1.
- The same brand of PEG-PBT as described in Example 1 can be used. Poly(ester amide)-8,4 having the formula (IV) can be used:
- wherein n is a positive integer.
- The composition can contain about 75 μg poly(ester amide), and about 25 μg PEG-PBT. The composition can be applied onto the dried reservoir layer to form a topcoat layer, using the same spraying technique and equipment as described above, followed by drying, e.g., by baking. The poly(ester amide) shown by formula (IV) is expected to degrade when exposed to bodily fluids such as blood to yield sebacic and glycolic acids and 1,4-butanediamine (putrescine), all of which are biocompatible.
- While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that changes and modifications can be made without departing from this invention in its broader aspects. Therefore, the appended claims are to encompass within their scope all such changes and modifications as fall within the true spirit and scope of this invention.
Claims (15)
1. A medical article, comprising:
(a) a medical substrate; and
(b) a coating deposited on the substrate, the coating comprising a first polymer and a second polymer, wherein the first polymer is a biologically degradable AB block copolymer, and the second polymer is a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5% water by mass of the biologically degradable polymer,
wherein the AB block copolymer is capable, at equilibrium and at room temperature, of absorbing about 5% or more water by mass of the AB block copolymer.
2. The medical article of claim 1 , wherein the ratio between the first polymer and the second polymer is between about 1:1 and about 1:99.
3. The medical article of claim 1 , wherein the ratio between the first polymer and the second polymer is between about 1:2 and about 1:49.
4. The medical article of claim 1 , wherein the ratio between the first polymer and the second polymer is between about 1:2 and about 1:19.
5. The medical article of claim 1 , wherein the medical article is a stent, graft, or a stent-graft.
6. The medical article of claim 1 , wherein the second polymer does not include or is substantially free of the AB polymeric blocks.
7. The medical article of claim 1 , wherein the AB block copolymer comprises a biocompatible polymeric moiety and a structural polymeric moiety.
8. The medical article of claim 7 , wherein the biocompatible polymeric moiety is selected from a group consisting of a poly(alkylene glycol), poly(2-hydroxyethyl methacrylate), poly(3-hydroxypropyl methacrylamide), hydroxylated poly(vinyl pyrrolidone), sulfonated dextran, sulfonated polystyrene, fibrin, fibrinogen, cellulose, starch, collagen, hyaluronic acid, heparin, a graft copolymer of poly(L-lysine)-graft-co-poly(ethylene glycol), and copolymers thereof.
9. The medical article of claim 8 , wherein the poly(alkylene glycol) is selected from a group consisting of poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene glycol), and poly(ethylene oxide-co-propylene oxide).
10. The medical article of claim 7 , wherein the structural polymeric moiety is selected from a group consisting of poly(D,L-lactide), poly(caprolactone), poly(caprolactone-co-D,L-lactide), poly(butylene terephthalate), poly(ester amide), poly(aspirin), poly(L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), and polydioxanone.
12. The medical article of claim 1 , wherein the second polymer is selected from a group consisting of poly(L-lactide), poly(D,L-lactide), poly(glycolide), poly(L-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(caprolactone), poly(L-lactide-co-caprolactone), poly(D,L-lactide-co-caprolactone), polyhydroxyalkanoates, poly(3-hydroxybutyrate), poly(4-hydroxybutyrate), poly(hydroxyvalerate), poly(3-hydroxybutyrate-co-valerate), poly(4-hydroxybutyrate-co-valerate), poly(ester amides), poly(anhydrides), poly(carbonates), poly(trimethylene carbonate-co-glycolide), poly(trimethylene carbonate-co-L-lactide), poly(trimethylene carbonate-co-D,L-lactide), poly(dioxanone), poly(phosphazenes), poly(orthoesters), poly(tyrosine-co-carbonates), polyalkylene oxalates, poly(glycerol-co-sebacic acid esters), cyanoacrylates, poly(amino acids), poly(lysine), poly(glutamic acid) and combinations thereof.
14. The medical article of claim 1 , additionally including a therapeutic substance.
15. A method of treating a disorder in a human being, comprising:
implanting in the human being a medical article of claim 1 , wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
US11185677B2 (en) | 2017-06-07 | 2021-11-30 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6926919B1 (en) * | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
AU2004226327A1 (en) | 2003-03-28 | 2004-10-14 | Innovational Holdings, Llc | Implantable medical device with beneficial agent concentration gradient |
US20050208093A1 (en) | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
US20050214339A1 (en) * | 2004-03-29 | 2005-09-29 | Yiwen Tang | Biologically degradable compositions for medical applications |
WO2006002399A2 (en) * | 2004-06-24 | 2006-01-05 | Surmodics, Inc. | Biodegradable implantable medical devices, methods and systems |
US8980300B2 (en) | 2004-08-05 | 2015-03-17 | Advanced Cardiovascular Systems, Inc. | Plasticizers for coating compositions |
WO2006047289A2 (en) * | 2004-10-21 | 2006-05-04 | Medtronic, Inc. | Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function |
US7390497B2 (en) * | 2004-10-29 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) filler blends for modulation of coating properties |
ATE421547T1 (en) * | 2004-12-22 | 2009-02-15 | California Inst Of Techn | DEGRADABLE POLYMERS AND PRODUCTION PROCESSES THEREOF |
US20060147491A1 (en) * | 2005-01-05 | 2006-07-06 | Dewitt David M | Biodegradable coating compositions including multiple layers |
US20060198868A1 (en) * | 2005-01-05 | 2006-09-07 | Dewitt David M | Biodegradable coating compositions comprising blends |
US8052637B2 (en) * | 2005-07-12 | 2011-11-08 | Abbott Laboratories | Medical device balloon |
US20070237803A1 (en) * | 2006-04-11 | 2007-10-11 | Medtronic Vascular, Inc. | Biodegradable Biocompatible Amphiphilic Copolymers for Coating and Manufacturing Medical Devices |
US8350087B2 (en) * | 2006-04-12 | 2013-01-08 | Agency For Science, Technology And Research | Biodegradable thermogelling polymer |
US7638344B2 (en) * | 2006-06-28 | 2009-12-29 | Surmodics, Inc. | Active agent eluting matrices with particulates |
US8685430B1 (en) | 2006-07-14 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Tailored aliphatic polyesters for stent coatings |
US8597673B2 (en) * | 2006-12-13 | 2013-12-03 | Advanced Cardiovascular Systems, Inc. | Coating of fast absorption or dissolution |
US10155881B2 (en) * | 2007-05-30 | 2018-12-18 | Abbott Cardiovascular Systems Inc. | Substituted polycaprolactone for coating |
US8133553B2 (en) | 2007-06-18 | 2012-03-13 | Zimmer, Inc. | Process for forming a ceramic layer |
US8309521B2 (en) | 2007-06-19 | 2012-11-13 | Zimmer, Inc. | Spacer with a coating thereon for use with an implant device |
US9737638B2 (en) | 2007-06-20 | 2017-08-22 | Abbott Cardiovascular Systems, Inc. | Polyester amide copolymers having free carboxylic acid pendant groups |
US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
US9814553B1 (en) | 2007-10-10 | 2017-11-14 | Abbott Cardiovascular Systems Inc. | Bioabsorbable semi-crystalline polymer for controlling release of drug from a coating |
US8608049B2 (en) | 2007-10-10 | 2013-12-17 | Zimmer, Inc. | Method for bonding a tantalum structure to a cobalt-alloy substrate |
US20090104241A1 (en) * | 2007-10-23 | 2009-04-23 | Pacetti Stephen D | Random amorphous terpolymer containing lactide and glycolide |
US20090110713A1 (en) * | 2007-10-31 | 2009-04-30 | Florencia Lim | Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices |
US8642062B2 (en) * | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
US8128983B2 (en) * | 2008-04-11 | 2012-03-06 | Abbott Cardiovascular Systems Inc. | Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network |
US20090285873A1 (en) * | 2008-04-18 | 2009-11-19 | Abbott Cardiovascular Systems Inc. | Implantable medical devices and coatings therefor comprising block copolymers of poly(ethylene glycol) and a poly(lactide-glycolide) |
US20090297584A1 (en) * | 2008-04-18 | 2009-12-03 | Florencia Lim | Biosoluble coating with linear over time mass loss |
US8916188B2 (en) | 2008-04-18 | 2014-12-23 | Abbott Cardiovascular Systems Inc. | Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block |
US8697113B2 (en) * | 2008-05-21 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Coating comprising a terpolymer comprising caprolactone and glycolide |
WO2010014703A2 (en) * | 2008-07-31 | 2010-02-04 | Boston Scientific Scimed, Inc. | Medical articles comprising biodegradable block copolymers |
US8697110B2 (en) | 2009-05-14 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Polymers comprising amorphous terpolymers and semicrystalline blocks |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5902875A (en) * | 1997-01-28 | 1999-05-11 | United States Surgical Corporation | Polyesteramide, its preparation and surgical devices fabricated therefrom |
US6395326B1 (en) * | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
US20020090398A1 (en) * | 1999-11-16 | 2002-07-11 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US20020103526A1 (en) * | 2000-12-15 | 2002-08-01 | Tom Steinke | Protective coating for stent |
EP1247537A1 (en) * | 2001-04-04 | 2002-10-09 | Isotis B.V. | Coating for medical devices |
US20050025799A1 (en) * | 2003-07-30 | 2005-02-03 | Hossainy Syed F. A. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
US7311980B1 (en) * | 2004-08-02 | 2007-12-25 | Advanced Cardiovascular Systems, Inc. | Polyactive/polylactic acid coatings for an implantable device |
US8846070B2 (en) * | 2004-03-29 | 2014-09-30 | Advanced Cardiovascular Systems, Inc. | Biologically degradable compositions for medical applications |
Family Cites Families (201)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US559922A (en) * | 1896-05-12 | Fare indicator and recorder | ||
US3900632A (en) | 1970-02-27 | 1975-08-19 | Kimberly Clark Co | Laminate of tissue and random laid continuous filament web |
US3839743A (en) | 1972-04-21 | 1974-10-08 | A Schwarcz | Method for maintaining the normal integrity of blood |
US4110497A (en) | 1976-07-02 | 1978-08-29 | Snyder Manufacturing Co., Ltd. | Striped laminate and method and apparatus for making same |
JPS6037735B2 (en) * | 1978-10-18 | 1985-08-28 | 住友電気工業株式会社 | Artificial blood vessel |
US4346028A (en) | 1979-12-14 | 1982-08-24 | Monsanto Company | Asbestiform crystalline calcium sodium or lithium phosphate, preparation and compositions |
DE3019996A1 (en) * | 1980-05-24 | 1981-12-03 | Institute für Textil- und Faserforschung Stuttgart, 7410 Reutlingen | HOHLORGAN |
US4902289A (en) * | 1982-04-19 | 1990-02-20 | Massachusetts Institute Of Technology | Multilayer bioreplaceable blood vessel prosthesis |
US4517687A (en) | 1982-09-15 | 1985-05-21 | Meadox Medicals, Inc. | Synthetic woven double-velour graft |
US4656083A (en) * | 1983-08-01 | 1987-04-07 | Washington Research Foundation | Plasma gas discharge treatment for improving the biocompatibility of biomaterials |
US4594407A (en) | 1983-09-20 | 1986-06-10 | Allied Corporation | Prosthetic devices derived from krebs-cycle dicarboxylic acids and diols |
US5197977A (en) * | 1984-01-30 | 1993-03-30 | Meadox Medicals, Inc. | Drug delivery collagen-impregnated synthetic vascular graft |
US4633873A (en) * | 1984-04-26 | 1987-01-06 | American Cyanamid Company | Surgical repair mesh |
US4879135A (en) | 1984-07-23 | 1989-11-07 | University Of Medicine And Dentistry Of New Jersey | Drug bonded prosthesis and process for producing same |
ES8705239A1 (en) * | 1984-12-05 | 1987-05-01 | Medinvent Sa | A device for implantation and a method of implantation in a vessel using such device. |
US4718907A (en) * | 1985-06-20 | 1988-01-12 | Atrium Medical Corporation | Vascular prosthesis having fluorinated coating with varying F/C ratio |
US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US4743252A (en) * | 1986-01-13 | 1988-05-10 | Corvita Corporation | Composite grafts |
EP0257091B1 (en) | 1986-02-24 | 1993-07-28 | Robert E. Fischell | An intravascular stent and percutaneous insertion system |
US4878906A (en) | 1986-03-25 | 1989-11-07 | Servetus Partnership | Endoprosthesis for repairing a damaged vessel |
DE3778195D1 (en) * | 1986-04-07 | 1992-05-21 | Agency Ind Science Techn | ANTITHROMOGENIC MATERIAL. |
US4740207A (en) * | 1986-09-10 | 1988-04-26 | Kreamer Jeffry W | Intralumenal graft |
US4723549A (en) * | 1986-09-18 | 1988-02-09 | Wholey Mark H | Method and apparatus for dilating blood vessels |
US4722335A (en) * | 1986-10-20 | 1988-02-02 | Vilasi Joseph A | Expandable endotracheal tube |
US4816339A (en) * | 1987-04-28 | 1989-03-28 | Baxter International Inc. | Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation |
US5527337A (en) * | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
US5059211A (en) * | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
DK530787D0 (en) | 1987-10-09 | 1987-10-09 | Bukh Meditec | DEVICE FOR INTRODUCTION IN A BODY |
US4877030A (en) | 1988-02-02 | 1989-10-31 | Andreas Beck | Device for the widening of blood vessels |
FR2627460B1 (en) | 1988-02-19 | 1990-06-29 | Cebal | DISPENSER FOR PASTY PRODUCT COMPRISING A SIDE DISPENSING AXIAL PUSH-BUTTON AND A MASKING ELEMENT OF ITS OUTPUT PORT |
US5192311A (en) * | 1988-04-25 | 1993-03-09 | Angeion Corporation | Medical implant and method of making |
US4994298A (en) * | 1988-06-07 | 1991-02-19 | Biogold Inc. | Method of making a biocompatible prosthesis |
US5502158A (en) | 1988-08-08 | 1996-03-26 | Ecopol, Llc | Degradable polymer composition |
US5328471A (en) * | 1990-02-26 | 1994-07-12 | Endoluminal Therapeutics, Inc. | Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens |
DE68922497T2 (en) | 1988-08-24 | 1995-09-14 | Marvin J Slepian | ENDOLUMINAL SEAL WITH BISDEGRADABLE POLYMERS. |
US5019090A (en) * | 1988-09-01 | 1991-05-28 | Corvita Corporation | Radially expandable endoprosthesis and the like |
CA1322628C (en) | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
US5085629A (en) * | 1988-10-06 | 1992-02-04 | Medical Engineering Corporation | Biodegradable stent |
FI85223C (en) | 1988-11-10 | 1992-03-25 | Biocon Oy | BIODEGRADERANDE SURGICAL IMPLANT OCH MEDEL. |
US4977901A (en) | 1988-11-23 | 1990-12-18 | Minnesota Mining And Manufacturing Company | Article having non-crosslinked crystallized polymer coatings |
CA2004833A1 (en) | 1988-12-08 | 1990-06-08 | Leonard Armand Trudell | Prosthesis of foam polyurethane and collagen and uses thereof |
US5163958A (en) | 1989-02-02 | 1992-11-17 | Cordis Corporation | Carbon coated tubular endoprosthesis |
US5289831A (en) * | 1989-03-09 | 1994-03-01 | Vance Products Incorporated | Surface-treated stent, catheter, cannula, and the like |
NZ228382A (en) | 1989-03-17 | 1992-08-26 | Carter Holt Harvey Plastic Pro | Drug administering coil-like device for insertion in body cavity of animal |
US5108755A (en) * | 1989-04-27 | 1992-04-28 | Sri International | Biodegradable composites for internal medical use |
US5100429A (en) * | 1989-04-28 | 1992-03-31 | C. R. Bard, Inc. | Endovascular stent and delivery system |
US4990158A (en) | 1989-05-10 | 1991-02-05 | United States Surgical Corporation | Synthetic semiabsorbable tubular prosthesis |
US5084065A (en) * | 1989-07-10 | 1992-01-28 | Corvita Corporation | Reinforced graft assembly |
US5971954A (en) | 1990-01-10 | 1999-10-26 | Rochester Medical Corporation | Method of making catheter |
DK0441516T3 (en) | 1990-02-08 | 1995-06-12 | Howmedica | Inflatable catheter |
US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5156623A (en) | 1990-04-16 | 1992-10-20 | Olympus Optical Co., Ltd. | Sustained release material and method of manufacturing the same |
US5123917A (en) * | 1990-04-27 | 1992-06-23 | Lee Peter Y | Expandable intraluminal vascular graft |
WO1991017744A1 (en) | 1990-05-14 | 1991-11-28 | Jernberg Gary R | Surgical implant and method incorporating chemotherapeutic agents |
US5290271A (en) * | 1990-05-14 | 1994-03-01 | Jernberg Gary R | Surgical implant and method for controlled release of chemotherapeutic agents |
EP0528993A1 (en) | 1990-05-18 | 1993-03-03 | STACK, Richard S. | Intraluminal stent |
US5279594A (en) * | 1990-05-23 | 1994-01-18 | Jackson Richard R | Intubation devices with local anesthetic effect for medical use |
US6060451A (en) * | 1990-06-15 | 2000-05-09 | The National Research Council Of Canada | Thrombin inhibitors based on the amino acid sequence of hirudin |
US5236447A (en) | 1990-06-29 | 1993-08-17 | Nissho Corporation | Artificial tubular organ |
US5342395A (en) | 1990-07-06 | 1994-08-30 | American Cyanamid Co. | Absorbable surgical repair devices |
US5112457A (en) * | 1990-07-23 | 1992-05-12 | Case Western Reserve University | Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants |
US5455040A (en) | 1990-07-26 | 1995-10-03 | Case Western Reserve University | Anticoagulant plasma polymer-modified substrate |
CA2090435C (en) * | 1990-08-28 | 2000-12-12 | Peter J. Schmitt | Self-supporting woven vascular graft |
SE9102448D0 (en) | 1990-08-28 | 1991-08-26 | Meadox Medicals Inc | RAVEL RESISTANT, SELF-SUPPORTING WOVEN GRAFT |
US5163952A (en) | 1990-09-14 | 1992-11-17 | Michael Froix | Expandable polymeric stent with memory and delivery apparatus and method |
JPH0717314Y2 (en) * | 1990-10-18 | 1995-04-26 | ソン ホーヨン | Self-expanding intravascular stent |
CA2094908C (en) | 1990-12-06 | 2000-02-08 | Byron Kent Hayes | Implantable bioabsorbable article |
US5163951A (en) | 1990-12-27 | 1992-11-17 | Corvita Corporation | Mesh composite graft |
CS277367B6 (en) | 1990-12-29 | 1993-01-13 | Krajicek Milan | Three-layered vascular prosthesis |
AU650700B2 (en) * | 1991-03-08 | 1994-06-30 | Keiji Igaki | Luminal stent, holding structure therefor and device for attaching luminal stent |
US5383925A (en) * | 1992-09-14 | 1995-01-24 | Meadox Medicals, Inc. | Three-dimensional braided soft tissue prosthesis |
US5356433A (en) | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6515009B1 (en) * | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
WO1993006792A1 (en) | 1991-10-04 | 1993-04-15 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5234457A (en) | 1991-10-09 | 1993-08-10 | Boston Scientific Corporation | Impregnated stent |
US5282860A (en) * | 1991-10-16 | 1994-02-01 | Olympus Optical Co., Ltd. | Stent tube for medical use |
US5167614A (en) | 1991-10-29 | 1992-12-01 | Medical Engineering Corporation | Prostatic stent |
US5756476A (en) * | 1992-01-14 | 1998-05-26 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell proliferation using antisense oligonucleotides |
CA2087132A1 (en) * | 1992-01-31 | 1993-08-01 | Michael S. Williams | Stent capable of attachment within a body lumen |
US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
US5352515A (en) * | 1992-03-02 | 1994-10-04 | American Cyanamid Company | Coating for tissue drag reduction |
CA2118520C (en) * | 1992-04-24 | 1999-08-10 | Dirkjan Bakker | Devices for preventing tissue adhesion |
DE4222380A1 (en) | 1992-07-08 | 1994-01-13 | Ernst Peter Prof Dr M Strecker | Endoprosthesis implantable percutaneously in a patient's body |
US5306294A (en) * | 1992-08-05 | 1994-04-26 | Ultrasonic Sensing And Monitoring Systems, Inc. | Stent construction of rolled configuration |
US5514379A (en) * | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
US5342621A (en) | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
US5830461A (en) | 1992-11-25 | 1998-11-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods for promoting wound healing and treating transplant-associated vasculopathy |
US5342348A (en) | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
EP0604022A1 (en) | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method for its manufacture |
US5443458A (en) | 1992-12-22 | 1995-08-22 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method of manufacture |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
FR2702954B1 (en) | 1993-03-03 | 1997-09-26 | Andrew H Cragg | Prosthesis and intraluminal implant. |
WO1994021196A2 (en) | 1993-03-18 | 1994-09-29 | C.R. Bard, Inc. | Endovascular stents |
US5474563A (en) * | 1993-03-25 | 1995-12-12 | Myler; Richard | Cardiovascular stent and retrieval apparatus |
US5441515A (en) | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5994341A (en) * | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
EG20321A (en) | 1993-07-21 | 1998-10-31 | Otsuka Pharma Co Ltd | Medical material and process for producing the same |
PT716610E (en) * | 1993-08-26 | 2006-08-31 | Genetics Inst Llc | MORPHOGENETIC PROTEINS OF BONES FOR HUMANS TO BE USED IN NEURAL REGENERATION |
US5723004A (en) | 1993-10-21 | 1998-03-03 | Corvita Corporation | Expandable supportive endoluminal grafts |
US5389106A (en) | 1993-10-29 | 1995-02-14 | Numed, Inc. | Impermeable expandable intravascular stent |
US5599301A (en) * | 1993-11-22 | 1997-02-04 | Advanced Cardiovascular Systems, Inc. | Motor control system for an automatic catheter inflation system |
US5626611A (en) | 1994-02-10 | 1997-05-06 | United States Surgical Corporation | Composite bioabsorbable materials and surgical articles made therefrom |
US5556413A (en) | 1994-03-11 | 1996-09-17 | Advanced Cardiovascular Systems, Inc. | Coiled stent with locking ends |
US5965720A (en) | 1994-03-18 | 1999-10-12 | Lynx Therapeutics, Inc. | Oligonucleotide N3'→P5' phosphoramidates |
US5726297A (en) * | 1994-03-18 | 1998-03-10 | Lynx Therapeutics, Inc. | Oligodeoxyribonucleotide N3' P5' phosphoramidates |
US5599922A (en) | 1994-03-18 | 1997-02-04 | Lynx Therapeutics, Inc. | Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties |
ATE310839T1 (en) | 1994-04-29 | 2005-12-15 | Scimed Life Systems Inc | STENT WITH COLLAGEN |
US5629077A (en) * | 1994-06-27 | 1997-05-13 | Advanced Cardiovascular Systems, Inc. | Biodegradable mesh and film stent |
US5670558A (en) | 1994-07-07 | 1997-09-23 | Terumo Kabushiki Kaisha | Medical instruments that exhibit surface lubricity when wetted |
US5554120A (en) | 1994-07-25 | 1996-09-10 | Advanced Cardiovascular Systems, Inc. | Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters |
US5593403A (en) * | 1994-09-14 | 1997-01-14 | Scimed Life Systems Inc. | Method for modifying a stent in an implanted site |
US5578073A (en) | 1994-09-16 | 1996-11-26 | Ramot Of Tel Aviv University | Thromboresistant surface treatment for biomaterials |
EP0785774B1 (en) * | 1994-10-12 | 2001-01-31 | Focal, Inc. | Targeted delivery via biodegradable polymers |
US5707385A (en) * | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
US5637113A (en) * | 1994-12-13 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
US6017577A (en) * | 1995-02-01 | 2000-01-25 | Schneider (Usa) Inc. | Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices |
US5919570A (en) | 1995-02-01 | 1999-07-06 | Schneider Inc. | Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices |
US5876743A (en) * | 1995-03-21 | 1999-03-02 | Den-Mat Corporation | Biocompatible adhesion in tissue repair |
JP3586815B2 (en) * | 1995-03-24 | 2004-11-10 | タキロン株式会社 | Manufacturing method of cell structure |
US5605696A (en) * | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US5820917A (en) * | 1995-06-07 | 1998-10-13 | Medtronic, Inc. | Blood-contacting medical device and method |
US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
AU716005B2 (en) * | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
US5667767A (en) | 1995-07-27 | 1997-09-16 | Micro Therapeutics, Inc. | Compositions for use in embolizing blood vessels |
US5830879A (en) | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
US6048964A (en) | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
PT876165E (en) * | 1995-12-18 | 2006-10-31 | Angiotech Biomaterials Corp | COMPOSITIONS OF RETICULATED POLYMERS AND PROCESSES FOR THEIR USE |
JP2000509014A (en) | 1996-03-11 | 2000-07-18 | フォーカル,インコーポレイテッド | Polymer delivery of radionuclides and radiopharmaceuticals |
US6071266A (en) * | 1996-04-26 | 2000-06-06 | Kelley; Donald W. | Lubricious medical devices |
US5874165A (en) * | 1996-06-03 | 1999-02-23 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto polymeric subtrates |
US5914182A (en) * | 1996-06-03 | 1999-06-22 | Gore Hybrid Technologies, Inc. | Materials and methods for the immobilization of bioactive species onto polymeric substrates |
US5830178A (en) | 1996-10-11 | 1998-11-03 | Micro Therapeutics, Inc. | Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide |
US5800516A (en) | 1996-08-08 | 1998-09-01 | Cordis Corporation | Deployable and retrievable shape memory stent/tube and method |
US5855618A (en) * | 1996-09-13 | 1999-01-05 | Meadox Medicals, Inc. | Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin |
CA2266478C (en) | 1996-09-23 | 2002-11-12 | Focal, Inc. | Polymerizable biodegradable polymers including carbonate or dioxanone linkages |
US5833651A (en) * | 1996-11-08 | 1998-11-10 | Medtronic, Inc. | Therapeutic intraluminal stents |
US5877263A (en) * | 1996-11-25 | 1999-03-02 | Meadox Medicals, Inc. | Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents |
US5741881A (en) * | 1996-11-25 | 1998-04-21 | Meadox Medicals, Inc. | Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions |
US5728751A (en) | 1996-11-25 | 1998-03-17 | Meadox Medicals, Inc. | Bonding bio-active materials to substrate surfaces |
IT1289728B1 (en) * | 1996-12-10 | 1998-10-16 | Sorin Biomedica Cardio Spa | SYSTEM AND EQUIPMENT DEVICE THAT INCLUDES IT |
US5980972A (en) | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
US6159951A (en) | 1997-02-13 | 2000-12-12 | Ribozyme Pharmaceuticals Inc. | 2'-O-amino-containing nucleoside analogs and polynucleotides |
US6240616B1 (en) * | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US5879697A (en) * | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
US5891192A (en) * | 1997-05-22 | 1999-04-06 | The Regents Of The University Of California | Ion-implanted protein-coated intralumenal implants |
US6056993A (en) * | 1997-05-30 | 2000-05-02 | Schneider (Usa) Inc. | Porous protheses and methods for making the same wherein the protheses are formed by spraying water soluble and water insoluble fibers onto a rotating mandrel |
DE19731021A1 (en) | 1997-07-18 | 1999-01-21 | Meyer Joerg | In vivo degradable metallic implant |
US5980928A (en) | 1997-07-29 | 1999-11-09 | Terry; Paul B. | Implant for preventing conjunctivitis in cattle |
US6340367B1 (en) * | 1997-08-01 | 2002-01-22 | Boston Scientific Scimed, Inc. | Radiopaque markers and methods of using the same |
US6174330B1 (en) * | 1997-08-01 | 2001-01-16 | Schneider (Usa) Inc | Bioabsorbable marker having radiopaque constituents |
US6245103B1 (en) * | 1997-08-01 | 2001-06-12 | Schneider (Usa) Inc | Bioabsorbable self-expanding stent |
US5980564A (en) | 1997-08-01 | 1999-11-09 | Schneider (Usa) Inc. | Bioabsorbable implantable endoprosthesis with reservoir |
US6121027A (en) | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
US5854382A (en) | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
US6117979A (en) | 1997-08-18 | 2000-09-12 | Medtronic, Inc. | Process for making a bioprosthetic device and implants produced therefrom |
AU750947C (en) | 1997-09-22 | 2003-05-22 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Nucleic acid catalysts with endonuclease activity |
US6015541A (en) * | 1997-11-03 | 2000-01-18 | Micro Therapeutics, Inc. | Radioactive embolizing compositions |
US6093463A (en) | 1997-12-12 | 2000-07-25 | Intella Interventional Systems, Inc. | Medical devices made from improved polymer blends |
US5957975A (en) | 1997-12-15 | 1999-09-28 | The Cleveland Clinic Foundation | Stent having a programmed pattern of in vivo degradation |
US6626939B1 (en) * | 1997-12-18 | 2003-09-30 | Boston Scientific Scimed, Inc. | Stent-graft with bioabsorbable structural support |
US6224626B1 (en) * | 1998-02-17 | 2001-05-01 | Md3, Inc. | Ultra-thin expandable stent |
US6110188A (en) | 1998-03-09 | 2000-08-29 | Corvascular, Inc. | Anastomosis method |
US6113629A (en) | 1998-05-01 | 2000-09-05 | Micrus Corporation | Hydrogel for the therapeutic treatment of aneurysms |
DE59913189D1 (en) | 1998-06-25 | 2006-05-04 | Biotronik Ag | Implantable, bioabsorbable vessel wall support, in particular coronary stent |
DE19856983A1 (en) | 1998-06-25 | 1999-12-30 | Biotronik Mess & Therapieg | Implantable, bioresorbable vascular wall support, in particular coronary stent |
US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
CA2338788A1 (en) | 1998-09-02 | 2000-03-09 | Scimed Life Systems, Inc. | Drug delivery device for stent |
DE19843254C2 (en) * | 1998-09-10 | 2000-07-06 | Schering Ag | Use of polymer mixtures containing cyanoacrylate or methylene malonic ester for coating medical devices and implants, medical implants and processes for their production |
US6350277B1 (en) | 1999-01-15 | 2002-02-26 | Scimed Life Systems, Inc. | Stents with temporary retaining bands |
US6656489B1 (en) * | 1999-02-10 | 2003-12-02 | Isotis N.V. | Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material |
EP1175236A1 (en) | 1999-04-23 | 2002-01-30 | Agion Technologies, L.L.C. | Stent having antimicrobial agent |
US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
US6177523B1 (en) * | 1999-07-14 | 2001-01-23 | Cardiotech International, Inc. | Functionalized polyurethanes |
US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6713119B2 (en) * | 1999-09-03 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for a prosthesis and a method of forming the same |
JP3499475B2 (en) * | 1999-09-10 | 2004-02-23 | 株式会社トップ | Manufacturing method of synthetic resin medical device |
US6491666B1 (en) * | 1999-11-17 | 2002-12-10 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
US6338739B1 (en) | 1999-12-22 | 2002-01-15 | Ethicon, Inc. | Biodegradable stent |
US6981987B2 (en) * | 1999-12-22 | 2006-01-03 | Ethicon, Inc. | Removable stent for body lumens |
WO2001054745A2 (en) | 2000-01-25 | 2001-08-02 | Edwards Lifesciences Corporation | Bioactive coatings to prevent tissue overgrowth on artificial heart valves |
US6527801B1 (en) * | 2000-04-13 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
US7875283B2 (en) * | 2000-04-13 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Biodegradable polymers for use with implantable medical devices |
US6746773B2 (en) * | 2000-09-29 | 2004-06-08 | Ethicon, Inc. | Coatings for medical devices |
US20020082679A1 (en) * | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
US6752826B2 (en) * | 2001-12-14 | 2004-06-22 | Thoratec Corporation | Layered stent-graft and methods of making the same |
US7291165B2 (en) * | 2002-01-31 | 2007-11-06 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US6756449B2 (en) * | 2002-02-27 | 2004-06-29 | Medtronic, Inc. | AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods |
AU2003239175A1 (en) * | 2002-04-24 | 2003-11-10 | Poly-Med, Inc. | Multifaceted endovascular stent coating for preventing restenosis |
CA2484374C (en) * | 2002-05-09 | 2011-05-17 | Hemoteq Gmbh | Medical products comprising a haemocompatible coating, production and use thereof |
JP2003325655A (en) * | 2002-05-09 | 2003-11-18 | Inst Of Physical & Chemical Res | Stent and stent graft for treating inside of blood vessel |
WO2004022124A1 (en) * | 2002-09-06 | 2004-03-18 | Abbott Laboratories | Medical device having hydration inhibitor |
US20040148014A1 (en) | 2002-09-13 | 2004-07-29 | Juha-Pekka Nuutinen | Drawn expanded stent |
US7329413B1 (en) * | 2003-11-06 | 2008-02-12 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof |
US20050112170A1 (en) * | 2003-11-20 | 2005-05-26 | Hossainy Syed F. | Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same |
US7229471B2 (en) | 2004-09-10 | 2007-06-12 | Advanced Cardiovascular Systems, Inc. | Compositions containing fast-leaching plasticizers for improved performance of medical devices |
-
2004
- 2004-03-29 US US10/812,780 patent/US20050214339A1/en not_active Abandoned
-
2005
- 2005-03-24 JP JP2007506274A patent/JP5463003B2/en not_active Expired - Fee Related
- 2005-03-24 EP EP05731208.4A patent/EP1737505B1/en not_active Not-in-force
- 2005-03-24 WO PCT/US2005/009881 patent/WO2005097220A1/en active Application Filing
- 2005-03-24 ES ES05731208.4T patent/ES2570001T3/en active Active
-
2008
- 2008-07-29 US US12/182,066 patent/US8846070B2/en not_active Expired - Fee Related
-
2014
- 2014-09-02 US US14/475,379 patent/US20140370073A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5902875A (en) * | 1997-01-28 | 1999-05-11 | United States Surgical Corporation | Polyesteramide, its preparation and surgical devices fabricated therefrom |
US20020090398A1 (en) * | 1999-11-16 | 2002-07-11 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US6395326B1 (en) * | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
US20020103526A1 (en) * | 2000-12-15 | 2002-08-01 | Tom Steinke | Protective coating for stent |
EP1247537A1 (en) * | 2001-04-04 | 2002-10-09 | Isotis B.V. | Coating for medical devices |
US20050025799A1 (en) * | 2003-07-30 | 2005-02-03 | Hossainy Syed F. A. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
US8846070B2 (en) * | 2004-03-29 | 2014-09-30 | Advanced Cardiovascular Systems, Inc. | Biologically degradable compositions for medical applications |
US7311980B1 (en) * | 2004-08-02 | 2007-12-25 | Advanced Cardiovascular Systems, Inc. | Polyactive/polylactic acid coatings for an implantable device |
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US11717670B2 (en) | 2017-06-07 | 2023-08-08 | Shifamed Holdings, LLP | Intravascular fluid movement devices, systems, and methods of use |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
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Also Published As
Publication number | Publication date |
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JP2007530231A (en) | 2007-11-01 |
JP5463003B2 (en) | 2014-04-09 |
US20080279898A1 (en) | 2008-11-13 |
US20050214339A1 (en) | 2005-09-29 |
US8846070B2 (en) | 2014-09-30 |
WO2005097220A1 (en) | 2005-10-20 |
EP1737505B1 (en) | 2016-03-16 |
EP1737505A1 (en) | 2007-01-03 |
ES2570001T3 (en) | 2016-05-13 |
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