US20150216719A1 - Treatment systems and methods for treating cellulite and for providing other treatments - Google Patents
Treatment systems and methods for treating cellulite and for providing other treatments Download PDFInfo
- Publication number
- US20150216719A1 US20150216719A1 US14/611,052 US201514611052A US2015216719A1 US 20150216719 A1 US20150216719 A1 US 20150216719A1 US 201514611052 A US201514611052 A US 201514611052A US 2015216719 A1 US2015216719 A1 US 2015216719A1
- Authority
- US
- United States
- Prior art keywords
- skin
- tissue
- temperature
- cooling
- freeze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B18/0206—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques ultrasonic, e.g. for destroying tissue or enhancing freezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/04—Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H1/00—Apparatus for passive exercising; Vibrating apparatus ; Chiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
- A61H1/006—Apparatus for applying pressure or blows for compressive stressing of a part of the skeletal structure, e.g. for preventing or alleviating osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H1/00—Apparatus for passive exercising; Vibrating apparatus ; Chiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
- A61H1/008—Apparatus for applying pressure or blows almost perpendicular to the body or limb axis, e.g. chiropractic devices for repositioning vertebrae, correcting deformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00273—Anchoring means for temporary attachment of a device to tissue
- A61B2018/00291—Anchoring means for temporary attachment of a device to tissue using suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00458—Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
- A61B2018/00464—Subcutaneous fat, e.g. liposuction, lipolysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00714—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00875—Resistance or impedance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00994—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0237—Characteristics of handpieces or probes with a thermoelectric element in the probe for cooling purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/04—Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery
- A61B2090/0463—Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery against cooling or freezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/06—Measuring instruments not otherwise provided for
- A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
- A61B2090/065—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension for measuring contact or contact pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0003—Face
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0004—Eyes or part of the face surrounding the eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0018—Trunk or parts thereof
- A61F2007/0019—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0029—Arm or parts thereof
- A61F2007/0036—Hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0039—Leg or parts thereof
- A61F2007/0045—Foot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0039—Leg or parts thereof
- A61F2007/0047—Sole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0052—Body part for treatment of skin or hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
- A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
- A61F2007/0075—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a Peltier element, e.g. near the spot to be heated or cooled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0087—Hand-held applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0093—Heating or cooling appliances for medical or therapeutic treatment of the human body programmed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0095—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator
- A61F2007/0096—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator with a thermometer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Rehabilitation Therapy (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Radiology & Medical Imaging (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pathology (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Surgical Instruments (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
- The present application claims priority to U.S. Provisional Application Ser. No. 61/943,257, filed Feb. 21, 2014, U.S. Provisional Application Ser. No. 61/934,549, filed Jan. 31, 2014, and U.S. Provisional Application Ser. No. 61/943,250, filed Feb. 21, 2014, the disclosures of which are incorporated herein by reference in their entireties.
- The following commonly assigned U.S. patent applications and U.S. patents are incorporated herein by reference in their entirety:
- U.S. Patent Publication No. 2008/0287839 entitled “METHOD OF ENHANCED REMOVAL OF HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS AND TREATMENT APPARATUS HAVING AN ACTUATOR”;
- U.S. Pat. No. 6,032,675 entitled “FREEZING METHOD FOR CONTROLLED REMOVAL OF FATTY TISSUE BY LIPOSUCTION”;
- U.S. Patent Publication No. 2007/0255362 entitled “CRYOPROTECTANT FOR USE WITH A TREATMENT DEVICE FOR IMPROVED COOLING OF SUBCUTANEOUS LIPID-RICH CELLS”;
- U.S. Pat. No. 7,854,754 entitled “COOLING DEVICE FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS”;
- U.S. Patent Publication No. 2011/0066216 entitled “COOLING DEVICE FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS”;
- U.S. Patent Publication No. 2008/0077201 entitled “COOLING DEVICES WITH FLEXIBLE SENSORS”;
- U.S. Patent Publication No. 2008/0077211 entitled “COOLING DEVICE HAVING A PLURALITY OF CONTROLLABLE COOLING ELEMENTS TO PROVIDE A PREDETERMINED COOLING PROFILE”;
- U.S. Patent Publication No. 2009/0118722, filed Oct. 31, 2007, entitled “METHOD AND APPARATUS FOR COOLING SUBCUTANEOUS LIPID-RICH CELLS OR TISSUE”;
- U.S. Patent Publication No. 2009/0018624 entitled “LIMITING USE OF DISPOSABLE SYSTEM PATIENT PROTECTION DEVICES”;
- U.S. Patent Publication No. 2009/0018623 entitled “SYSTEM FOR TREATING LIPID-RICH REGIONS”;
- U.S. Patent Publication No. 2009/0018625 entitled “MANAGING SYSTEM TEMPERATURE TO REMOVE HEAT FROM LIPID-RICH REGIONS”;
- U.S. Patent Publication No. 2009/0018627 entitled “SECURE SYSTEM FOR REMOVING HEAT FROM LIPID-RICH REGIONS”;
- U.S. Patent Publication No. 2009/0018626 entitled “USER INTERFACES FOR A SYSTEM THAT REMOVES HEAT FROM LIPID-RICH REGIONS”;
- U.S. Pat. No. 6,041,787 entitled “USE OF CRYOPROTECTIVE AGENT COMPOUNDS DURING CRYOSURGERY”;
- U.S. Pat. No. 8,285,390 entitled “MONITORING THE COOLING OF SUBCUTANEOUS LIPID-RICH CELLS, SUCH AS THE COOLING OF ADIPOSE TISSUE”;
- U.S. Provisional Patent Application Ser. No. 60/941,567 entitled “METHODS, APPARATUSES AND SYSTEMS FOR COOLING THE SKIN AND SUBCUTANEOUS TISSUE”;
- U.S. Pat. No. 8,275,442 entitled “TREATMENT PLANNING SYSTEMS AND METHODS FOR BODY CONTOURING APPLICATIONS”;
- U.S. patent application Ser. No. 12/275,002 entitled “APPARATUS WITH HYDROPHILIC RESERVOIRS FOR COOLING SUBCUTANEOUS LIPID-RICH CELLS”;
- U.S. patent application Ser. No. 12/275,014 entitled “APPARATUS WITH HYDROPHOBIC FILTERS FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS”;
- U.S. Patent Publication No. 2010/0152824 entitled “SYSTEMS AND METHODS WITH INTERRUPT/RESUME CAPABILITIES FOR COOLING SUBCUTANEOUS LIPID-RICH CELLS”;
- U.S. Pat. No. 8,192,474 entitled “TISSUE TREATMENT METHODS”;
- U.S. Patent Publication No. 2010/0280582 entitled “DEVICE, SYSTEM AND METHOD FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS”;
- U.S. Patent Publication No. 2012/0022518 entitled “COMBINED MODALITY TREATMENT SYSTEMS, METHODS AND APPARATUS FOR BODY CONTOURING APPLICATIONS”;
- U.S. Publication No. 2011/0238050 entitled “HOME-USE APPLICATORS FOR NON-INVASIVELY REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS VIA PHASE CHANGE COOLANTS, AND ASSOCIATED DEVICES, SYSTEMS AND METHODS”;
- U.S. Publication No. 2011/0238051 entitled “HOME-USE APPLICATORS FOR NON-INVASIVELY REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS VIA PHASE CHANGE COOLANTS, AND ASSOCIATED DEVICES, SYSTEMS AND METHODS”;
- U.S. Publication No. 2012/0239123 entitled “DEVICES, APPLICATION SYSTEMS AND METHODS WITH LOCALIZED HEAT FLUX ZONES FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS”;
- U.S. patent application Ser. No. 13/830,413 entitled “MULTI-MODALITY TREATMENT SYSTEMS, METHODS AND APPARATUS FOR ALTERING SUBCUTANEOUS LIPID-RICH TISSUE”;
- U.S. patent application Ser. No. 13/830,027 entitled “TREATMENT SYSTEMS WITH FLUID MIXING SYSTEMS AND FLUID-COOLED APPLICATORS AND METHODS OF USING THE SAME”;
- U.S. Provisional Patent Application No. 61/943,251 entitled “TREATMENT SYSTEMS AND METHODS FOR TREATING CELLULITE”; and
- U.S. Provisional Patent Application No. 61/943,257 entitled “TREATMENT SYSTEMS, METHODS, AND APPARATUS FOR REDUCING IRREGULARITIES CAUSED BY CELLULITE.”
- The present disclosure relates generally to treatment systems and methods for cooling targeted tissue. In particular, several embodiments are directed to treatment systems and methods for cooling tissue to improve the appearance of treatment sites with gynoid lipodystrophy or other skin irregularities. Embodiments are also disclosed for improving the appearance of skin, body contouring, and treating various skin conditions.
- It is often desirable to improve the appearance of bodies in many respects and treat various skin conditions. One example is the unattractive appearance of cellulite (gynoid lipodystrophy). Cellulite can be caused by subcutaneous fat lobules protruding or penetrating into the dermis and can be the consequence of, for example, an engorged adipose layer sequestered within the deep subcutis hypodermal fibrous septa, a weakened and/or degraded extracellular matrix, microcirculation compression resulting in decreased oxygen tension and hypoxia, and inflammatory edema. Cellulite is typically recognized by localized skin surface nodularity and dimpling considered to be cosmetically unappealing and often referred to as a cottage cheese appearance or an orange peel appearance. Unfortunately, cellulite has proved to be a difficult and vexing problem to treat, although the demand for an effective treatment has been and remains quite high.
- Other examples where improvement of body appearance are needed are in the fields of body contouring and skin appearance. Improvements are also desired in treating various skin conditions, such as hyperhidrosis. Hyperhidrosis is a condition associated with excessive sweating that results from the overproduction and secretion of sweat from sweat glands and can cause discomfort and embarrassment.
- Accordingly, it is an objective of various embodiments of the present invention to address these and other needs.
- In the drawings, identical reference numbers identify similar elements or acts. The sizes and relative positions of elements in the drawings are not necessarily drawn to scale.
-
FIG. 1A is a schematic cross-sectional view of the skin, dermis, and subcutaneous tissue of a subject with cellulite. -
FIG. 1B is a schematic cross-sectional view of the skin, dermis, and subcutaneous tissue of the subject inFIG. 1A showing a reduction in the appearance of cellulite. A treatment device is shown applied to the skin. -
FIG. 2 is a partially schematic, isometric view of a treatment system for non-invasively removing heat from target areas of a subject in accordance with an embodiment of the technology. -
FIGS. 3 to 7 are flow diagrams illustrating methods for treating target areas in accordance with embodiments of the technology. -
FIG. 8 is a partially schematic, isometric view of a treatment system for non-invasively removing heat from target areas of a subject in accordance with an embodiment of the technology. -
FIG. 9 is a partial cross-sectional view illustrating a treatment device suitable to be used in treatment systems in accordance with embodiments of the technology. -
FIGS. 10A to 10C are schematic, cross-sectional views illustrating treatment devices in accordance with embodiments of the technology. -
FIG. 11 is a partial cross-sectional view illustrating a vacuum treatment device in accordance with another embodiment of the technology. -
FIG. 12 is a schematic block diagram illustrating computing system software modules and subcomponents of a computing device suitable to be used in treatment systems in accordance with embodiments of the technology. - The present disclosure describes treatment systems and methods for cooling tissue to produce freeze-induced injuries for improving the appearance of areas with gynoid lipodystrophy or other irregularities, improving the appearance of skin, body contouring, treating various skin conditions, or combinations thereof. Several of the details set forth below are provided to describe the following examples and methods in a manner sufficient to enable a person skilled in the relevant art to practice, make, and use them. Several of the details and advantages described below, however, may not be necessary to practice certain examples and methods of the technology. Additionally, the technology may include other examples and methods that are within the scope of the technology but are not described in detail.
- Reference throughout this specification to “one example,” “an example,” “one embodiment,” or “an embodiment” means that a particular feature, structure, or characteristic described in connection with the example is included in at least one example of the present technology. Thus, the occurrences of the phrases “in one example,” “in an example,” “one embodiment,” or “an embodiment” in various places throughout this specification are not necessarily all referring to the same example. Furthermore, the particular features, structures, routines, blocks, stages, or characteristics may be combined in any suitable manner in one or more examples of the technology. The headings provided herein are for convenience only and are not intended to limit or interpret the scope or meaning of the technology.
- Various aspects of the technology are directed to treatment methods for affecting cellulite of a human subject's body and other treatments. In one embodiment, the method can include removing heat from a target region between the subject's epidermis and subdermal tissue to produce a freeze event localized in the dermal layer which causes a reduction of visible cellulite. In various embodiments, the target region can be cooled to a temperature equal to or less than about −1° C., −2° C., −5° C., −10° C., −15° C., −20° C., −30° C., or −40° C. at a depth equal to or greater than about 1 mm, 2 mm, 3 mm, or 4 mm. In some embodiments, most of the partially or totally frozen tissue by volume can be in a single layer of tissue, such as the epidermal layer, dermal layer, or subcutaneous layer. In other embodiments, multiple layers of tissue can be frozen. The subject's skin can be periodically or continuously heated to limit or prevent thermal damage to non-targeted tissue, in particular to sometimes protect the epidermal layer.
- At least some embodiments are directed to reducing or eliminating cellulite, wrinkles, loose skin, sagging skin, poor skin tone or texture, and other skin irregularities often considered to be cosmetically unappealing. As used herein, “improving the appearance of cellulite” is intended to include any combination of improving skin tone, thickening of the skin, improving tissue elasticity, or other similar effects to reduce cellulite. As used herein, “improving the appearance of skin” is intended to include any combination of skin tightening, improving skin tone or texture, thickening of the skin, elimination or reducing fine lines and wrinkles or deeper wrinkles, increasing skin smoothness, or improving the appearance of cellulite, or other similar effects. What is not included in these terms is treating the skin to such an extent so as to cause hyperpigmentation (skin darkening) and/or hypopigmentation (skin lightening) either immediately after the treatment or hours or a day or days or weeks thereafter.
- Some aspects of the technology are directed to treatment methods for affecting tissue of a human subject's body. In one embodiment, the method can include cooling tissue to produce a freeze event that reduces or eliminates cellulite by affecting at least one of skin tone, thicknesses of the tissue layers (e.g., increasing the thicknesses of the dermal layer and/or epidermal layer), and/or tissue elasticity. In certain embodiments, the method also includes inhibiting damage to non-targeted tissue of the subject's skin while producing the freeze event. In some embodiments, the freeze event can include injury to at least some of the subject's skin (e.g., epidermis, dermis, etc.), subcutaneous adipose tissue, or other targeted tissue.
- Freeze events can result in freeze trauma and/or freeze injury that can be contained in a layer of tissue. In embodiments in which the freeze event is centralized in the dermis, the treatment method can include inhibiting damage to the epidermis while producing the freeze event. A cryoprotectant can be applied to the surface of the subject's skin prior to or during heat removal to protect an epidermis and possibly other layers. In other embodiments, energy (e.g., heat, radiofrequency energy, electromagnetic energy, electric fields, ultrasound energy, light energy, etc.) can be applied to the subject's skin to inhibit damage to the epidermis. Excessive damage to the epidermis can sometimes lead to undesired skin coloration issues. In some supercooling embodiments, supercooling can be used to target tissue at the desired depth without using any cryoprotectant. Non-targeted tissue in the skin, such as the epidermis, can be heated above its freezing point before initiating crystallization of the remaining supercooled tissue. Accordingly, crystallization in the supercooled tissue can be induced without damaging the subject's epidermis and possibly some deeper skin layers. In some embodiments, the surface of the skin and tissue therebeneath is supercooled. The surface of the skin is then warmed above a freezing temperature. After warming the surface of the skin, the supercooled tissue is nucleated to initiate a partial or total freeze event.
- With or without freezing, at least some embodiments of the technology are directed to controlling a cooling device or providing other means for sufficiently protecting the epidermis from injuries that cause hyperpigmentation (skin darkening) and/or hypopigmentation (skin lightening). The other means for protection can include, without limitation, heating the epidermis to a non-freezing temperature while deeper tissue remains cold to induce injury thereto and/or applying a cryoprotectant to a surface of the skin to provide freeze protection to the epidermis while allowing deeper tissue to be more affected by the cooling/cold treatment.
- At least some embodiments of non-invasive treatments for reducing cellulite can include producing wound remodeling (e.g., healing) phase resulting from freeze-induced tissue trauma to produce enhancements in structural integrity of the epidermal-dermal junction and/or epidermal textural quality. The freeze-induced trauma can include thermal injuries that are selected to reduce skin surface irregularities caused by cellulite.
- Further aspects of the technology are directed to systems and methods for affecting a target region of a human subject's body by removing heat from the target region to alter subdermal connective tissue while lipid-rich cells in the subcutaneous layer are not substantially affected. The method can optionally include applying a cryoprotectant and/or warming the surface of the skin. For example, in one embodiment, heat removal includes freezing tissue of the fibrous septum to affect the fibrous septum while the epidermis is not substantially affected. The thermal injury can cause beneficially generation of fibrous tissue, remodeling of the fibrous septum, or the like. In various embodiments, heat can be removed from the target region to affect cells (e.g., reduce, destroy, and/or damage cells), alter tissue characteristics, or combinations thereof. In some embodiments, a treatment system can (1) reduce fat in the superficial compartment, (2) alter skin tone/thickness/elasticity due to a freeze event (e.g., cold injury) and resultant healing cascade, and/or (3) affect connective tissue (including the septa) as a result of cold injury and resultant healing.
- Tissue characteristics affected by cryotherapy can include, without limitation, tissue strength, tissue elasticity, tissue layer thickness, and/or skin tone. In some embodiments, cryotherapy can increase the elasticity of a targeted tissue layer, such as the skin, epidermis, and/or dermis. For example, the dermis can be cooled to produce a freeze event that causes thermal injury to the dermal tissue. The resultant wound remodeling can increase the strength and/or elasticity of the dermis. The severity of the freeze event can be selected to achieve the desired change in strength and/or elasticity while non-targeted tissue, such as epidermal or subdermal tissue, can remain generally unaffected. In some embodiments, cryotherapy can increase the thicknesses of multiple layers of tissue. For example, the epidermis and dermis can be wounded to increase their thicknesses due to wound remodeling. In yet further embodiments, freeze injury causes fibrosis in the form of fibroblast proliferation and/or increased collagen.
- At least some freeze events disclosed herein can promote a natural body response that reduces an orange peel appearance, a cottage cheese appearance, etc. The subject's natural body response can include thickening of the epidermis, dermis, layers of connective tissue (e.g., regions of cellular matrix overlaying fat pockets), and/or other subdermal tissues. Layers for thickening can be selected based on the ability to control the freeze events and the location and extent of the associated injury/trauma. For example, one or more layers of the epidermis (e.g., stratum corneum, stratum lucidum, stratum granlosum, stratum spinosum, and/or stratum basale) can be the site of wound formation and remodeling. The papillary layer and/or reticular layer of the dermis can also be the site of wound formation and remodeling.
- At least some embodiments are systems and methods for selective non-invasive cooling of tissue to produce a freeze event at a depth equal to or greater than about 1 mm, 2 mm, 3 mm, or 5 mm. The depth can be selected based on the location of the treatment site (e.g., hips, buttock, thighs, etc.). The target region can be cooled to a temperature equal to or lower than about 0° C., −5° C., −10° C., −15° C., −20° C., −25° C., −30° C., −35° C., or −40° C. for a treatment period. The treatment period can be equal to or longer than about 1 second, 2 seconds, 3 seconds, 5 seconds, 30 seconds, 1 minute, 5 minutes, 10 minutes, 30 minutes, or other time periods selected based on the location of targeted tissue and/or desired resultant healing.
- Applicators disclosed herein can include elements (e.g., electrodes, vibrators, etc.) for delivering energy, such as radiofrequency energy, electromagnetic energy, infrared energy, light energy, ultraviolet energy, microwave energy, ultrasound energy (e.g., low frequency ultrasound, high frequency ultrasound, etc.), mechanical massage, and/or electric fields (e.g., AC or DC electric fields). The energy can inhibit or reduce freeze damage in non-targeted regions, such as an epidermis, while allowing more aggressive cooling of a targeted region. In non-targeted cells or structures, non-thermal energy parameters may be selected to reduce ice crystal nucleation, size and/or length, reduce freezing lethality, or the like. In targeted cells or structures, non-thermal energy may be used to initiate crystal nucleation, growth, etc. Thus, non-thermal energy can be selectively applied to control cryotherapy. Thermal energy can be used to protect non-targeted tissue, such as facial subcutaneous fat, when cryogenically treating superficial dermal structures and/or epidermal structures on the face. Additionally or alternatively, non-targeted tissue can be protected by a chemical cryoprotectant. Some applicators can treat epidermal and/or dermal structures, such as collagen and/or elastin for skin tightening and dermal thickening, glands (e.g., apocrine glands, eccrine glands, etc.), nerve tissue (e.g., superficial nerves), and/or hair follicles.
- At least some aspects are directed to systems and devices that enable supercooling of target tissue to alter and reduce adipose tissue, contour sites, or perform other cryotherapy procedures. Aspects of the disclosure are further directed to systems or methods for protecting non-targeted cells, such as non-lipid-rich cells (e.g., cells in the dermal and/or epidermal skin layers), by preventing or limiting freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. For example, treatment systems and devices can supercool treatment sites without nucleating crystals. Non-targeted tissue can be heated to localize the supercooling, and after localizing the supercooled tissue, supercooled body fluids/lipids can then be intentionally nucleated to damage, reduce, disrupt, or otherwise affect targeted cells. Nucleation can be induced by delivering an alternating current to the tissue, applying a nucleating solution onto the surface of the skin (for example one that includes bacteria which initiate nucleation), and/or by creating a mechanical perturbation to the tissue, such as by use of vibration, ultrasound energy, etc.
-
FIG. 1A is a schematic cross-sectional view of tissue with gynoid lipodystrophy. Gynoid lipodystrophy typically is a hormonally mediated condition characterized by the uneven distribution of adipose tissue in the subcutaneous layer that gives rise to an irregular, dimpled skin surface common in women. Cellulite-prone tissue can be characterized by the uneven thickness and distribution of some fibrous septae strands. Piérard, G. E., Nizet, J. L, Piérard-Franchimont, C., “Cellulite: From Standing Fat Herniation to Hypodermal Stretch Marks,” Am. J. Dermatol. 22:1, 34-37 (2000). As shown schematically, cottage-cheese like dimpling of theskin 10 may be located, for example, along the legs (e.g., thighs, buttock, etc.). Thedermis 12 is between the epidermis 14 andsubcutaneous layer 16. Thesubcutaneous layer 16 has connective collagenous tissue calledfibrous septae 20 that subdivides adipose tissue into fat cell chambers or lobules 18 (also called “papillae adiposae”). Thefibrous septae 20, which for females tend to generally be oriented perpendicular to the skin surface and anchor thedermal layers 12 to the underlying fascia and muscle (not shown), are organized within thesubcutaneous layer 16 to form a connective web around thefat lobules 18. Subcutaneous adipose cells and theirlobules 18 are not uniformly distributed throughout thesubcutaneous tissue layer 16 and exhibit regional differences in size and shape. These regional differences can, in part, be due to gender, age, genetics, hormones and physical conditioning among other physiological factors. - The number, sizes, distribution, and orientation of the
fibrous septae 20 also vary by body location, gender, and age. Histological studies have shown that fibrous septae architecture in females differs from that in males. In males,fibrous septae 20 tend to form an intersecting network that divide the papillae adiposae into small, polygonal units. In contrast,fibrous septae 20 in females tend to be oriented perpendicularly to the cutaneous surface, creating fat cell chambers that are columnar in shape and sequestered by the connective strands and the overlayingdermis layer 12. When the intersectingfibrous septae 20 are more uniform in size and elasticity as is often a characteristic of males, the forces within and between the fibrous septae and their surrounding tissue tend to be distributed relatively evenly. However, the columnar architecture of thefibrous septae 20 found in some females can result in an uneven distribution of forces throughout the subcutaneous tissue. In particular, and without being bound by theory, it is believed that this uneven distribution of forces is partially manifested by thecolumnar fibrous septae 20 being held in a state of tension by the underlying fascia and other tissue, resulting in a tethering or anchoring effect at the point where eachsuch septum 20 connects with thedermal tissue 12. This tethering or anchoring is in turn manifested at the skin surface aslow spots 22. The septae tends to herniate as thepapillae adiposae 18 bulge into thedermal tissue 12 and result inhigh spots 23. When viewed over a larger area of a few square centimeters, the non-homogeneous nature of the skin surface's relative high and low spots results in a dimpled or irregular appearance characteristic of cellulite often referred to as a cottage cheese appearance or orange peel appearance. - The vertical pull of the fibrous septum 20 (e.g., pulling in a direction substantially perpendicular to the skin) can be reduced eliminate or reduce bumpiness of the
subdermal fat lobules 18. Wound remodeling affect the tension in connective tissue extending from thedermis 12 to the subcutaneous muscle (not shown). Localized freezing of thesubcutaneous tissue 16 can reduce the number and/or size of lipid-rich cells of thefat lobules 18 to reduce lobule bulging. Additionally or alternatively, vertical bands of thefibrous septum 20, or portions of the bands, to reduce pulling on thedermis 12, thus reducing bulging offat lobules 18. In some embodiments, the cellular matrix between thefat lobules 18 and thedermis 12 can be damaged in order to produce remodeling that ultimately increases the strength and/or elasticity of the cellular matrix. Freezing of dermal tissue can produce wound healing/remodeling that strengthens and/or thickens the dermal tissue to help flatten the fat lobules. Freezing of epidermal tissue can produce wound healing/remodeling that strengthens and/or thickens the epidermal tissue to further flatten theskin 10. Accordingly, cryotherapy can be designed to target the epidermis, dermis, and/or subcutaneous structures. -
FIG. 1B is a schematic cross-sectional view of theskin 10 and subcutaneousadipose tissue 16 of the subject inFIG. 1A showing a reduction in the appearance of cellulite in accordance with aspects of the present technology. A treatment device in the form of a thermoelectric applicator 104 (“applicator 104”) has been applied to and cooled theskin 10 to produce a freeze-induced injury that affected theepidermis 14,dermis 12,fibrous septae 20, and/or subcutaneousadipose tissue 16 to minimize, reduce, or eliminate at least the appearance of gynoid lipodystrophy.FIG. 1B shows theskin 10 after cryotherapy has been performed. The interface between thelobules 18 and thedermis 12 can be generally flat to help flatten the surface ofskin 10. As shown inFIGS. 1A and 1B , thelobules 18 have flattened so that lobuleflat regions 24 face thedermis 12. As such, the treatedskin 10 ofFIG. 1B can have a much more even or regular/smooth appearance than theskin 10 ofFIG. 1A . -
FIG. 2 and the following discussion provide a brief, general description of an example of asuitable treatment system 100 in which aspects of the technology can be implemented. Thetreatment system 100 can be configured to control hypothermia to treat the site of cellulite manifested by skin dimpling and nodularity. In some cellulite treatments, thetreatment system 100 can weaken, destroy, or otherwise injure the tissue (e.g., fibrous septum or other connective tissue) that pulls on the dermis. It is also thought that the wound-healing response following a freeze-induced injury caused by theapplicator 104 can result in remodeling of the underlying connective tissue and changes in skin characteristics (e.g., increased in thickness) that otherwise reduce or alter the appearance of cellulite. The freeze wound can result in tissue damage and/or destruction of the cells and connective tissue with reference to the superficial skin layers (e.g., epidermis and/or dermis). The dedicated wound repair and the wound remodeling process can result in the enhancement of the structural integrity and textural quality of skin and, thereby, restore the skin to a desired clinical outcome. The wound remodeling process can be selected based on the damage potential, repair process, or the like. The mechanisms of tissue injury in cryotherapy can involve direct cellular injury (e.g., damage to the cellular machinery), vascular injury, and/or freeze-stimulated immunologic injury. - The
system 100 can also freeze the upper layers of skin. Without being bound by theory, it is believed that low temperatures may potentially cause damage in the epidermis and/or dermis via at least intracellular and/or extracellular ice formation. The ice may expand and rupture the cell wall, but it may also form sharp crystals that locally pierce the cell wall as well as vital internal organelles, either or both resulting in cell death. When extracellular water freezes to form ice, the remaining extracellular fluid becomes progressively more concentrated with solutes. The high solute concentration of the extracellular fluid may cause intracellular fluid be driven through the semi-permeable cellular wall by osmosis resulting in cell dehydration and death. Such selective tissue injury can induce healing events in the tissue that has positive effects on skin appearance including a reduction in surface irregularities in the surface of the skin. - As shown in
FIG. 1B , theapplicator 104 has a heat-exchangingsurface 19 in thermal contact with atreatment site 9 along theskin 10. A heat/ing cooling device 103 of theapplicator 104 can cool and affect tissue at a cooling zone 21 (shown in phantom line) with dimensions and shape selected based on the cryotherapy procedure to be performed. A central region of thecooling zone 21 can be at a maximum depth of, for example, about 0.25 mm to about 2 mm, about 0.25 mm to about 1 mm, about 0.5 mm to about 1 mm, about 0.5 mm to about 2 mm, or about 0.5 mm to about 4 mm. In some embodiments, the coolingzone 21 can comprise mostly epidermal and dermal tissue. Surrounding tissue may also be cooled but can be at sufficiently high temperatures to avoid thermal injury. In some procedures, the coolingzone 21 can comprise most of the tissue located directly between the heat-exchangingsurface 19 and a region of thesubcutaneous tissue 16 directly beneath the heat-exchangingsurface 19. For example, at least 60%, 70%, 80%, 90%, or 95% of the tissue directly between the heat-exchangingsurface 19 and the subcutaneous tissue can be located within the coolingzone 21. In other procedures, the coolingzone 21 can be deep enough to includesubcutaneous tissue 16 to target lipid-rich cells of thelobules 18, thefibrous septum 20, or other subcutaneous tissue. The temperature profile across the heat-exchangingsurface 19 can be constant or varying to achieve the desiredcooling zone 21. - The
applicator 104 ofFIGS. 1B and 2 can also thermally damage subdermal tissue, such as the connective tissue of the fibrous septum (i.e., bands of connective tissue extending generally perpendicular to the skin) to help lengthen the connective tissue, thereby reducing bulging of the fat lobules toward the dermis. Additionally, the connective tissue can be altered without substantially affecting other tissue. In some procedures, the connective tissue of the fibrous septum is affected while lipid-rich cells in the subcutaneous adipose tissue are not substantially affected by controlling the cooling to not sufficiently cool the deeper subcutaneous adipose tissue to inflict injury thereto. In other procedures, the connective tissue and the lipid-rich cells in the subcutaneous layer (e.g., subcutaneous adipose tissue) are affected in the same cooling routine or sequentially performed cooling routines while epidermal tissue and/or dermal tissue are not substantially affected by either heating these latter layers or using a cryoprotectant to protect them. Theapplicator 104 can also be suitable for reducing skin surface irregularities, such as dimpling and nodularity usually associated with cellulite, by cooling or freezing cells residing in the superficial skin layers (e.g., dermal and epidermal layers). Tissue alteration by cooling and/or freezing is believed to be an intermediate and/or final result of one or more mechanisms acting alone or in combination. It is thought that a wound-healing response following a freeze-induced injury can result in remodeling of the underlying connective tissue and changes skin characteristics (e.g., increased in skin thickness) that otherwise reduce or alter the appearance of cellulite. - In several embodiments, apoptosis of the subcutaneous lipid-rich cells is a desirable outcome for beneficially altering (e.g., sculpting and/or reducing) adipose tissue contributing to cellulite. Apoptosis, also referred to as “programmed cell death”, is a genetically-induced death mechanism by which cells self-destruct without incurring damage to surrounding tissues. An ordered series of biochemical events may induce cells to morphologically change. These changes include cellular blebbing, loss of cell membrane asymmetry and attachment, cell shrinkage, chromatin condensation, and chromosomal DNA fragmentation. Injury via an external stimulus, such as cold exposure, is one mechanism that can induce apoptosis in cells. Nagle, W. A., Soloff, B. L., Moss, A. J. Jr., Henle, K. J. “Cultured Chinese Hamster Cells Undergo Apoptosis After Exposure to Cold but Nonfreezing Temperatures” Cryobiology 27, 439-451 (1990). One aspect of apoptosis, in contrast to cellular necrosis (a traumatic form of cell death causing, and sometimes induced by, local inflammation), is that apoptotic cells express and display phagocytic markers on the surface of the cell membrane, thus marking the cells for phagocytosis by, for example, macrophages. As a result, phagocytes can engulf and remove the dying cells (e.g., the lipid-rich cells) without eliciting an immune response.
- Without being bound by theory, one mechanism of apoptotic lipid-rich cell death by cooling is believed to involve localized crystallization of lipids within the adipocytes or other lipid-producing cells (e.g., residing in exocrine cells) at temperatures that do not induce crystallization in non-lipid-rich cells. The crystallized lipids may selectively injure these cells, inducing apoptosis (and may also induce necrotic death if the crystallized lipids damage or rupture the bilayer lipid membrane of the adipocyte). Another mechanism of injury involves the lipid phase transition of those lipids within the cell's bilayer lipid membrane, which results in membrane disruption, thereby inducing apoptosis. This mechanism is well documented for many cell types and may be active when adipocytes, or lipid-rich cells, are cooled. Mazur, P., “Cryobiology: the Freezing of Biological Systems” Science, 68: 939-949 (1970); Quinn, P. J., “A Lipid Phase Separation Model of Low Temperature Damage to Biological Membranes” Cryobiology, 22: 128-147 (1985); Rubinsky, B., “Principles of Low Temperature Preservation” Heart Failure Reviews, 8, 277-284 (2003). Other possible mechanisms of adipocyte damage, described in U.S. Pat. No. 8,192,474, relates to ischemia/reperfusion injury that may occur under certain conditions when such cells are cooled as described herein. For instance, during treatment by cooling as described herein, the targeted adipose tissue (e.g., lipid-rich cells in the
lobules 18 ofFIG. 1A ) may experience a restriction in blood supply and thus be starved of oxygen due to isolation while pulled into, e.g., a vacuum cup, or simply as a result of the cooling which may affect vasoconstriction in the cooled tissue. In addition to the ischemic damage caused by oxygen starvation and the build-up of metabolic waste products in the tissue during the period of restricted blood flow, restoration of blood flow after cooling treatment may additionally produce reperfusion injury to the adipocytes due to inflammation and oxidative damage that is known to occur when oxygenated blood is restored to tissue that has undergone a period of ischemia. This type of injury may be accelerated by exposing the adipocytes to an energy source (via, e.g., thermal, electrical, chemical, mechanical, acoustic or other means) or otherwise increasing the blood flow rate in connection with or after cooling treatment as described herein. Increasing vasoconstriction in such adipose tissue by, e.g., various mechanical means (e.g., application of pressure or massage), chemical means or certain cooling conditions, as well as the local introduction of oxygen radical-forming compounds to stimulate inflammation and/or leukocyte activity in adipose tissue may also contribute to accelerating injury to such cells. Other yet-to-be understood mechanisms of injury may also exist. - In addition to the apoptotic mechanisms involved in lipid-rich cell death, local cold exposure may induce lipolysis (i.e., fat metabolism) of lipid-rich cells. For example, cold stress has been shown to enhance rates of lipolysis from that observed under normal conditions which serves to further increase the volumetric reduction of subcutaneous lipid-rich cells. Vallerand, A. L., Zamecnik. J., Jones, P. J. H., Jacobs, I. “Cold Stress Increases Lipolysis, FFA Ra and TG/FFA Cycling in Humans” Aviation, Space and Environmental Medicine 70, 42-50 (1999).
- Without being bound by theory, the selective effect of cooling on lipid-rich cells is believed to result in, for example, membrane disruption, shrinkage, disabling, destroying, removing, killing, or another method of lipid-rich cell alteration. For example, when cooling the subcutaneous tissues to a temperature lower than 37° C., subcutaneous lipid-rich cells can selectively be affected. In general, the cells in the epidermis and dermis of the subject 101 have lower amounts of lipids compared to the underlying lipid-rich cells forming the subcutaneous tissues. Since lipid-rich cells are more sensitive to cold-induced damage than non-lipid-rich epidermal or dermal cells, it is possible to use non-invasive or minimally invasive cooling to destroy lipid-rich cells without harming the overlying skin cells. In one embodiment, thermal conduction can be used to cool the desired layers of skin to a temperature above the freezing point of water, but below the freezing point of fat to reduce the number and/or size of lipid-rich lobules in the subcutaneous layer at a target region.
- In a typical procedure, a treatment device is positioned at least proximate to the surface of a subject's skin and heat is removed from the underlying tissue through the upper layers of the skin. This creates a thermal gradient with the coldest temperatures in the uppermost layers of skin near the cooling element. When cooling subcutaneous lipid-rich cells, the resulting thermal gradient causes the temperature of the upper layer(s) of the skin to be lower than that of the targeted underlying lipid-rich cells. For example, the
treatment system 100 can cool the surface of the skin to about −20° C. to about 20° C. In other embodiments, the skin temperature can be from about −40° C. to about 10° C., from about −20° C. to about 10° C., from about −18° C. to about 5° C., from about −15° C. to about 5° C., or from about −15° C. to about 0° C. In further embodiments, the surface of the skin can be cooled to lower than about −10° C., or in yet another embodiment, lower than about −15° C. to about −25° C., −30° C., −35° C., or −40° C. In further embodiments, the skin temperature can be lower than −25° C. to induce a deep freeze wound. - 1. Tissue Injuries
- Mechanisms of tissue injury in cryotherapy can involve direct cellular injury (e.g., damage to the cellular machinery) and/or vascular injury. For example, cellular injury can be controlled by thermal parameters, including (1) cooling rate, (2) end (or minimum) temperature, (3) time held at the minimum temperature (or hold time), and (4) thawing rate. In one example, increasing the hold time (e.g., at the minimum temperature) can allow the intracellular compartments to equilibrate with the extracellular space, thereby increasing cellular dehydration. Likewise, freeze events can also destroy or injure the microvasculature, the site of nutrient and oxygen delivery, thus causing necrosis in some examples. A common source for vascular injury is damage to the vessel wall due to vessel distension and engorgement from perivascular cellular dehydration. Additionally, vascular tissue injury can occur during tissue thawing. For example, high oxygen delivery to the tissue that occurs with hyperperfusion may cause free radical formation, which can, in turn, cause endothelial damage. In some embodiments, administration of free radical inhibitors may be able to limit this form of endothelial damage.
- Another mechanism of freezing injury is freeze-stimulated immunologic injury. Without being bound by theory, it is believed that after cryotherapy, the immune system of the host is sensitized to the disrupted tissue (e.g., lethally damaged tissue, undamaged tissue or sublethally injured tissue), which can be subsequently destroyed by the immune system.
- 2. Freeze Events
- Freeze events can elicit a desired response to minimize, reduce, or eliminate the appearance of cellulite. The freeze event can produce enhancements in structural integrity of target regions (e.g., the epidermal-dermal junction) and epidermal textural quality in the non-invasive treatment of cellulite. The location and extent of the crystallization can be selected based on the desired effects to the skin, epidermis, stratum corneum, or other targeted or non-targeted tissue.
- One cryotherapy procedure involves at least partially or totally freezing tissue to form crystals that alter targeted cells to cause skin tightening, skin thickening, fibrosis, etc. without destroying a significant amount of cells in the skin. The surface of the patient's skin can be cooled to temperatures no lower than, for example, −40° C. for a duration short enough to avoid, for example, excessive ice formation, permanent thermal damage, or significant hyperpigmentation or hypopigmentation. In another embodiment, destruction of skin cells can be avoided by periodically or continually applying heat to the surface of the patient's skin to keep or raise the skin's temperature above a freezing temperature. For example, the skin can be warmed to a temperature greater than 0° C., greater than 10° C., greater than 20° C., greater than 30° C., or other temperature sufficient to avoid, for example, excessive ice formation, permanent thermal damage, or significant hyperpigmentation or hypopigmentation of the non-targeted and/or epidermal tissue. In some treatments, the surface of the skin can be cooled to produce partial or total freeze events that cause apoptotic damage to skin tissue without causing significant damage to adjacent subcutaneous tissue.
- In some tissue-freezing procedures, the
applicator 104 can controllably freeze tissue and can detect the freezing event. After detecting the freeze event, theapplicator 104 can periodically or continuously remove heat from the target tissue to keep a volume of target tissue frozen for a suitable length of time to elicit a desired response. The detected freeze event can be a partial freeze event, a complete freeze event, etc. The freezing process can include forming crystals in intracellular and/or extracellular fluids (including lipids), and the crystals can be small enough to avoid disrupting membranes. This can prevent significant permanent tissue damage, such as necrosis. Some partial freeze events can include freezing mostly extracellular material without freezing a substantial amount of intercellular material, but other partial freeze events can include freezing mostly intercellular material without freezing a substantial amount of extracellular material. - The targeted tissue can remain in the frozen state long enough to be affected but short enough to avoid damaging non-targeted tissue. For example, the duration of the freeze event can be equal to, longer than, or shorter than about 10 seconds, 20 seconds, 30 seconds, or 45 seconds or about 1, 2, 3, 4, 5, or 10 minutes. The frozen tissue can be thawed to prevent necrosis and, in some embodiments, can be thawed within a period of time (e.g., about 20 seconds, about 30 seconds, about 45 seconds, about 1 minute, about 2 minutes, about 3 minutes, about 4 minutes, about 5 minutes, or about 10 minutes) after initiation of the freeze event. In some embodiments, the controlled freezing causes tightening of the skin, thickening of the skin, and/or a cold shock response at the cellular level in the skin. In one tissue-freezing embodiment, the
applicator 104 can produce a freeze event that includes, without limitation, partial or full thickness freezing (e.g., partial or complete freezing) of the patient's skin for a relatively short period of time to avoid cooling the adjacent subcutaneous tissue to a low enough temperature for subcutaneous cell death. A freeze event in the form of freeze injury of short duration and of mild to moderate intensity may produce, for example, a thicker, more resilient epidermis, which may improve the surface textural quality. In one embodiment, the duration of the freeze event and temperature of the tissue can be selected to achieve a desired thickened resilient epidermis. The greater the duration of freezing, the deeper the penetration of the trauma and tissue destruction. - The application of simultaneous or successive light to moderate freeze trauma to skin overlying sites of cellulite, in conjunction with selective cryotherapy induced reduction of subcutaneous lipid-rich cells at the sites of cellulite, can drive the wound remodeling phase in producing desirable structural and textural enhancements to the unsightly dimpling and nodularity usually associated with this condition. Selective localized freeze trauma (e.g., with pre-selected exposure parameters) should not initially disturb the dermal tensile strength but a transient increase in ECM structural integrity associated with collagen synthesis can occur as the result of wound remodeling. The combination of a structurally competent ECM with a consequential thickening of the epidermal barrier can provide a desired clinical outcome.
- 3. Supercooling
- A freezing point of a material is most reliably ascertained by warming frozen material slowly and measuring a temperature at which melting begins to occur. This temperature is generally not ambiguous if the material is slowly warmed. Partial melting will begin to occur at the freezing/melting point. Conversely, if a non-frozen material is cooled, its freezing/melting point is harder to ascertain since it is known that many materials can simply “supercool,” that is they can be cooled to a bulk temperature below their freezing/melting point and still remain in a non-frozen state. As used herein, “supercooling,” “supercooled,” “supercool,” etc., refers to a condition in which a material is at a temperature below its freezing/melting point but is still in an unfrozen or mostly unfrozen state.
- If skin is cooled in a controlled manner, targeted tissues can generally be supercooled below their freezing points without forming nucleation sites and/or microscopic crystals in extracellular fluid and/or intracellular fluid and thereby such tissues can reside in a supercooled unfrozen state. After supercooling, the supercooled tissue can then be nucleated via a mechanical perturbation (e.g., vibration, ultrasound pulse, change in pressure, etc.) to at least partially freeze that tissue. In one embodiment, the mechanical perturbation can induce crystallization to produce a freeze event (e.g., a partial freeze event, a complete freeze event, etc.) that causes targeted cells to be destroyed or damaged by ice crystal formation in intracellular and/or extracellular fluids. Other nucleation methods can also be used, such as applying a solution with a nucleating agent (such as a nucleating bacteria) onto the skin, or by applying an electrical alternating current, RF energy, microwave energy, ultrasound energy, etc. to the skin.
- The freezing process can include forming ice crystals small enough to avoid disrupting membranes to prevent significant permanent tissue damage (e.g., necrosis) but large enough to affect targeted cells. Some partial freeze events can include freezing mostly extracellular material without freezing a substantial amount of intercellular material. In other embodiments, partial freeze events can include freezing mostly intercellular material without freezing a substantial amount of extracellular material. Chemical cryoprotectants can be used to inhibit unwanted freezing of extracellular and intercellular material. In yet other embodiments, the partial freeze event can include freezing extracellular and intercellular material, and in other embodiments the material can be totally frozen. The frozen targeted tissue can remain in the frozen state long enough to be affected but short enough to avoid undesired thermal damage, including necrosis and/or damage to non-targeted cells. For example, the duration of the freeze event (e.g., the partial or complete freeze event) can be shorter or longer than about 10 seconds, 20 seconds, 30 seconds, or 45 seconds or about 1, 2, 3, 4, 5 or 10 minutes. The frozen tissue can be thawed to prevent undesired thermal damage and, in some embodiments, can be thawed within about 5 seconds, 10 seconds, 20 seconds, 30 seconds, or 45 seconds or about 1, 2, 3, 4, 5, or 10 minutes after initiation of the freeze event. In many embodiments, and as described in further detail herein, non-targeted cells can be protected by a warming cycle that brings the temperature of non-targeted cells to a temperature above their freezing temperatures prior to catalyzing a freeze event in the supercooled target tissue. For example, non-targeted tissue can be warmed to temperatures above about −1.8° C., above about 0° C., above about 5° C., above about 10° C., above about 20° C., above about 30° C., or above about 32° C. Warming can be accomplished by thermal heaters disposed on a surface of the applicator contacting or confronting a skin surface. Alternatively, if deeper tissue is not targeted, such tissue could be warmed using focused electrical currents which focus their energy below the skin surface, focused ultrasound which has a focal point for its energy below the skin surface, or RF energy.
- As discussed above, deep hypodermal fat cells are more easily damaged by low temperatures than the overlying dermal and/or epidermal layers of skin, and, as such, thermal conduction can be used to cool the desired layers of skin to a supercooled temperature suitable to freeze lipid-containing cells upon perturbation (e.g., a nucleating event). However, there is an associated risk of also freezing the uppermost layers of skin. Without being bound by theory, it is believed that low temperatures may potentially cause damage in the epidermis (e.g., stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum basale, etc.) via at least intracellular and/or extracellular ice formation. The ice may expand and rupture the cell wall, but it may also form sharp crystals that locally pierce the cell wall and vital internal organelles, either or both resulting in cell death. When extracellular liquid, such as water, freezes to form ice, the remaining extracellular fluid becomes progressively more concentrated with solutes. The high solute concentration of the extracellular fluid may cause intracellular fluid be driven through the semi-permeable cellular wall by osmosis resulting in cell dehydration and death. Accordingly, in one embodiment, mechanical perturbation and/or other catalyst for nucleation (e.g., RF energy, alternating electric fields, ultrasound energy, etc.) within the target tissue can be provided only following a protective increase of a temperature of non-targeted epidermal layers and/or dermal layers. The non-targeted layers can be warmed enough to avoid freezing of non-targeted tissue upon nucleation.
- As explained in more detail below, the treatment systems disclosed herein can employ a temperature treatment cycle to (a) cool (e.g., supercool) target tissue, for example, to a temperature below freezing without causing nucleation or microscopic crystallization of intracellular and/or extracellular fluids and (b) warm non-targeted tissue to increase its temperature above its freezing temperature. After warming the non-targeted tissue, the treatment systems can induce nucleation and hence freezing in the supercooled target tissue. In certain embodiments, the
treatment system 100 ofFIG. 2 can supercool a volume of tissue and can warm superficial skin layers to prevent injury to those superficial skin layers without the use of a chemical cryoprotectant. Alternatively, a cryoprotectant can further be employed to provide an added element of safety to minimize chances that undesired skin layers are undesirably damaged, particularly epidermal tissue, so as to prevent or minimize any chance of creating hyperpigmentation or hypopigmentation. - Formation of nucleation sites can be catalyzed by perturbation of the supercooled tissue. In particular embodiments, the supercooled region (e.g., body fluids within the targeted tissue cooled below their freezing temperatures) can be subjected to vibrations, changes in mechanical pressure, and/or ultrasound pulse(s) provided by the
applicator 104 to catalyze nucleation of the supercooled extracellular and/or intracellular fluids, lipids, etc. Nucleation perturbations can also be created by applying a nucleating solution to the skin, or by using electrical energy. The extracellular and/or intracellular fluids, lipids, etc. in the non-targeted skin layers under theapplicator 104 can be conductively warmed during the treatment (e.g., following transdermal cooling of targeted tissue) such that freeze injury is avoided in the non-targeted tissue when nucleation is initiated. - In one embodiment, to achieve supercooled temperatures of the targeted tissue without initiating nucleation, the treatment site can be cooled at a relatively slow rate (e.g., the temperature profile can cause a slow cooling of the tissue at the target region). For example, the rate of cooling can be either equal to, slower or faster than about 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 degrees C. per minute. A preferred rate of cooling is about either 2, 4, or 6 degrees C. per minute. Additionally or alternatively, a treatment device can apply a generally constant pressure during cooling to the supercooled temperature range to avoid pressure changes that would cause inadvertent nucleation. In a further embodiment, the targeted tissue can be cooled while the patient is held still (e.g., without movement of the treatment site) to avoid mechanically disturbing the supercooled tissue and unintentionally causing crystallization. The temperature of the non-targeted surface tissue can be warmed to a non-freezing temperature and/or a non-supercooled temperature prior to perturbation and subsequent freezing. In one embodiment, the warming cycle of the temperature profile can occur quickly such that the underlying and/or targeted tissue remains in the supercooled state throughout the warming cycle.
- At least some aspects of the technology are directed to systems and methods of treating a patient by cooling a surface of the patient's skin to a temperature sufficiently low to cause supercooling of targeted tissue below the skin surface. The surface of the skin can then be heated to a non-supercooled temperature while the targeted tissue remains in a supercooled state. After heating the non-targeted tissue, the supercooled targeted tissue can be controllably frozen. In some embodiments, nucleation can be controlled to cause partial freezing. In some procedures, the
applicator 104 ofFIGS. 1B and 2 can be kept generally stationary relative to the treatment site during cooling to avoid pressure changes that would cause nucleation. After heating non-targeted tissue, theapplicator 104 can cause nucleation in the supercooled targeted tissue by, for example, varying applied pressures, delivering energy (e.g., ultrasound energy, RF energy, ultrasound energy, microwave energy, etc.), applying fields (e.g., AC electric fields, DC electric fields, etc.), or providing other perturbations (e.g., vibrations, pulses, etc.), as well as combinations thereof. Because the non-targeted tissue has been warmed to a non-supercooled state, it does not experience a freeze event. In some embodiments, theapplicator 104 can include one or more movable plates (e.g., plates movable to vary applied pressures), rotatable eccentric masses, ultrasound transducers, electrical current generators, or other elements capable of providing nucleating perturbations. Vacuum applicators can increase and decrease vacuum levels to massage tissue, vary applied pressures, etc. - Once catalyzed, the partial or total freeze event can be detected, and a cooling device associated with the
treatment system 100 can be controlled to continue cooling the patient's skin so as to maintain a frozen state of targeted tissue for a desired period of time. The skin can be periodically or continuously cooled to keep a sufficient volume of the tissue in a frozen state. In some embodiments, the targeted tissue can be kept frozen for longer or shorter than about, for example, 1 second, 5 seconds, 10 seconds, 20 seconds, 30 seconds, 1 minute, several minutes, or other time period selected to reduce or limit frostbite or necrosis. Further, the temperature of the upper tissue of the skin can be detected, and thetreatment system 100 can be controlled to apply heat to the surface of the patient's skin for a preselected period of time to prevent freezing of non-targeted tissue. The preselected period of time can be longer or shorter than about 1, 2, 3, 4, or 5 seconds. Accordingly, non-targeted tissue can be protected without using a chemical cryoprotectant that may cause unwanted side effects. Alternatively, a cryoprotectant can also be used if an additional margin of safety for some tissue, such as the epidermis, is desired. - As described herein for targeting subcutaneous lipid-rich tissue, temperature treatment cycles can be used with the
treatment system 100 to transdermally cool (e.g., supercool) and selectively affect the patient's subcutaneous lipid-rich tissue while protecting non-lipid rich cells (e.g., residing in epidermal and/or dermal layers) at a temperature higher than the freezing temperatures of the subdermal tissue. Subcutaneous lipid-rich tissue can be supercooled and then frozen for a variety of therapeutic and cosmetic body-contouring applications, such as reduction of adipose tissue residing in identified portions of the patient's body (e.g., chin, cheeks, arms, pectoral areas, thighs, calves, buttocks, abdomen, “love handles”, back, breast, etc.). For example, use of the temperature treatment cycle with thetreatment system 100 to transdermally cool adipose tissue in the breast can be used for breast contouring and size reduction in a manner that facilitates protection of non-target tissue in the breast. Further examples include use of the temperature treatment cycle andtreatment system 100 to contour and/or reduce a volumetric size of treatment sites without substantially affecting non-targeted cells (e.g., cells in the epidermal and/or dermal layers). In some embodiments, the disclosed methods for therapeutic and cosmetic body-contouring applications can be performed with or without the use of chemical cryoprotectants. - In another embodiment, temperature treatment cycles can be used with the
treatment system 100 to cool the skin to selectively affect (e.g., injure, damage, and/or kill) secreting exocrine glandular cells or hair follicles. For example, secreting glandular cells residing in axilla apocrine sweat glands can be targeted by thetreatment system 100 for the treatment of hyperhidrosis. In another example, lipid-producing cells residing in or at least proximate to sebaceous glands (e.g., glandular epithelial cells) present in the dermis of a target region can be targeted by thetreatment system 100 for the treatment of acne or other skin condition. For example, thetreatment system 100 can be configured to reduce a temperature of a dermal layer of skin to reduce the temperature of lipid-producing cells residing in or at least proximate to sebaceous glands such that the targeted lipid-producing cells excrete a lower amount of sebum and/or there are fewer lipid-producing cells resulting in less sebum production within the targeted sebaceous glands. In another embodiment, the sebaceous glands are destroyed. Thetreatment system 100 can be configured, for example, to reduce a subject's acne by cooling (e.g., supercooling) acne-prone regions of the body (e.g., the face, back and chest). - 4. Healing of Freeze Wounds
- Healing of freeze injuries is different from healing of other types of injuries. For example, significant freezing can destroy cells; however, it does not completely or immediately destroy the surrounding connective tissue matrix. During the healing process, the cell population lost by freeze injury can be replaced by fibroblasts that migrate into the wound site. The degraded matrix and cellular debris at the wound site is removed and replaced gradually, thus enhancing the structural integrity of the wound base, as can be evidenced by a recovering wound site's pattern of birefringence. For example, following freeze injuries, the connective tissue matrix reveals dermal-like patterns of birefringence identical to that which is seen in normal, undamaged skin adjacent to the wound. This is consistent with other findings that the extracellular matrix is relatively resistant to freeze damage. Without being bound by theory, it is believed that wound contraction (e.g., a decrease in the size of the wound) does not occur following a freezing injury because of the relatively intact connective tissue matrix at the wound site.
- Freezing will destroy cells (e.g., epidermal keratinocytes), which are then removed by phagocytosis and replaced gradually, but freezing relatively spares the connective tissue matrix which can simulate the effects of a full-thickness skin graft to an open wound. Freezing of the skin can also promote separation between dermal and epidermal layers during the post-thaw period. For example, immediately following a freeze event, epidermal necrosis, pyknotic dermal fibroblasts and polymorphonuclear leukocytes are evident at the wound site. As such, inflammation, granulation tissue formation, and epithelialization are natural processes that occur during freeze wound healing.
- During the repair process following freeze injuries, the turnover of connective tissue matrix can be diminished or delayed. The residual matrix does, however, retain much of its structural integrity. This is observed by the absence of degradative denaturation as demonstrated by its patterns of birefringence. There is little collagenous phase change leading to fibrillar shrinkage at this stage.
- Wound repair resulting from a freeze event or injury follows a generalized pattern of healing phases that can be categorized depending upon the tissue depth of resulting injury. In one example in which freeze injury is limited to the epithelium, the epithelium restores or regenerates itself to a structure similar to the pre-injury state. In contrast, injuries inflicted on deeper structures or skin layers (e.g., the dermis) typically result in more extensive tissue repair process. For example, in acute partial thickness (e.g., superficial) freeze wounds, epithelialization and/or regeneration occurs by a different mechanism than full-thickness (e.g., deeper) wounds because adnexal structures are retained. These adnexal structures can serve as a reservoir of epithelial cells that migrate across the wound to repopulate the epidermis. Without being bound by theory, and in a particular example of wound healing following a freeze event, a wound healing process may progress through three or more healing phases. The healing phases may include, without limitation, (1) an inflammatory phase, (2) a proliferative phase, and (3) a remodeling phase.
- An onset of an inflammatory process can result in localized edema. Although the scars from the freeze-produced wounds can have larger surface areas due to the lack of wound contraction as described above, freeze wounds will, however, often remain more localized due to the absence of thermal radiation dynamics. For example, tissue examined 4 days after freeze injury often reveals edema and inflammatory cells at the interface between dead and surviving dermal tissue, and viable myofibroblasts can be visible within the central wound area associated with the residual connective tissue matrix. Approximately 10 days following a freeze injury or event, the wound site typically reveal islands of granulation tissue intermingled with residual connective tissue matrix within the area of healing. Few viable cells are evident within this residual matrix, but the islands of granulation tissue can contain densely packed myofibroblasts. During an inflammatory phase of healing, platelets are among the first cells to appear at the wound site. Platelets release platelet derived growth factor (PDGF), which upregulates soluble fibrinogen production. Fibrinogen is converted to insoluble strands of fibrin which form a matrix for the influx of monocytes and fibroblasts.
- During a proliferative phase of healing, cellular activity promotes epithelialization and fibroplasia. Fibronectin, produced initially from plasma, promotes epidermal migration by providing its own lattice. In freeze wounds, basal keratinocytes secrete collagenase-1 when in contact with fibrillar collagen. Collagenase-1 disrupts attachment to fibrillar collagen which allows for continued migration of keratinocytes into the wound site. It is during the proliferative phase that a healing process following freezing injury can result in a thicker epidermal layer with increased cellular activity.
- Extracellular matrix remodeling, cell maturation and cell apoptosis create the remodeling phase of wound repair, which processes can also overlap with tissue formation. Tissue remodeling describes transient to permanent changes in the tissue architecture that involve breaching of histological barriers, such as basement membranes, basal lamina, and extracellular matrix. Typically, the remodeling phase addresses the potential outcome of freeze wound repair as this phase creates structural integrity and textural quality enhancement, which can define the clinical outcome.
- Healing of freeze wounds also includes the deposition of matrix materials. Dermal macromolecules, such as fibronectin, hyaluronic acid, proteoglycans and collagen, are deposited and serve as a scaffolding for subsequent cellular migration and tissue support. Deposition and remodeling of the extracellular matrix proteins are dynamic processes and differences in the quantity of matrix proteins are evident between the center and the periphery of the wound. Since the collagen matrix is retained in freeze wounds at or near their pre-injury structural integrity levels, its tensile strength, which is a functional assessment of collagen, can be enhanced. Therefore, the collagen matrix can provide (in conjunction with the increase in epithelial layer thickness) a transient barrier to the pre-injury surface nodularity of cellulite.
-
FIG. 2 is a partially schematic isometric view of thenon-invasively treatment system 100 for performing cryotherapy procedures disclosed herein. The term “treatment system”, as used generally herein, refers to cosmetic or medical treatment systems. Thetreatment system 100 can be configured to alter a human subject's subcutaneous adipose tissue, reduce skin surface irregularities, and/or improve skin characteristics by cooling targeted cells. Thetreatment system 100 can include a treatment unit or tower 102 (“treatment tower 102”) connected to theapplicator 104 by supply and return fluid lines 108 a-b and power-lines 109 a-b. Theapplicator 104 can have one or more cooling devices powered by electrical energy delivered via the power-lines 109 a-b. A control line can provide communication between electrical components of theapplicator 104 and acontroller 114. Components of theapplicator 104 can be cooled using coolant that flows between theapplicator 104 and thetreatment tower 102 via the supply and return fluid lines 108 a-b. In one example, theapplicator 104 has a cooling device (e.g., cooling/heating device 103 ofFIG. 1B ) with one or more thermoelectric cooling elements and fluid channels through which the coolant flows to cool the thermoelectric cooling elements. The thermoelectric cooling elements can include heat-exchanging plates, Peltier devices, or the like. In other embodiments, theapplicator 104 can be a non-thermoelectric device that is heated/cooled using only coolant. - The
treatment tower 102 can include a chiller unit or module 106 (“chiller unit 106”) capable of removing heat from the coolant. Thechiller unit 106 can include one or more refrigeration units, thermoelectric chillers, or any other cooling devices and, in one embodiment, includes a fluid chamber configured to house the coolant delivered to theapplicator 104 via the fluid lines 108 a-b. In some procedures, thechiller unit 106 can circulate warm coolant to theapplicator 104 during periods of warming. In certain procedures, thechiller unit 106 can alternatingly provide heated and chilled coolant for warming and cooling periods. The circulating coolant can include water, glycol, synthetic heat transfer fluid, oil, a refrigerant, or any other suitable heat conducting fluid. Alternatively, a municipal water supply (e.g., tap water) can be used in place of or in conjunction with thetreatment tower 102. The fluid lines 108 a-b can be hoses or other conduits constructed from polyethylene, polyvinyl chloride, polyurethane, and/or other materials that can accommodate the particular coolant. One skilled in the art will recognize that there are a number of other cooling technologies that could be used such that the treatment unit, chiller unit, and/or applicator(s) need not be limited to those described herein. Additional features, components, and operation of thetreatment tower 102 are discussed in connection withFIG. 8 . -
FIG. 2 shows theapplicator 104 positioned to treat tissue along the leg of the subject 101. Feedback data from sensors of theapplicator 104 can be collected in real-time because real-time processing of such feedback data can help correctly and efficaciously administer treatment. In one example, real-time data processing is used to detect freeze events and to control theapplicator 104 to continue cooling the patient's skin after the freeze event is detected. Tissue can be monitored to keep the tissue in the frozen state (e.g., a partial or total frozen state) for a period of time. The period of time can be selected by thetreatment tower 102 or an operator and can be longer than about, for example, 10 seconds, 30 seconds, 1 minute, or a few minutes. Other periods of time can be selected if needed or desired. Theapplicator 104 can include sensors configured to measure tissue impedance, pressure applied to the subject 101, optical characteristics of tissue, and/or tissue temperatures. As described herein, sensors can be used to monitor tissue and, in some embodiments, to detect freeze events. The number and types of sensors can be selected based on the treatment to be performed. - Multiple applicators may be concurrently or sequentially used with the
treatment system 100 and applied during a treatment session, and such applicators can include, without limitation, vacuum applicators, belt applicators, and so forth. Each applicator may be designed to treat identified portions of the patient's body, such as chin, cheeks, arms, pectoral areas, thighs, calves, buttocks, abdomen, “love handles”, back, and so forth. For example, a vacuum applicator may be applied at the back region, and the belt applicator may be applied around the thigh region, either with or without massage or vibration. Exemplary applicators and their configurations usable or adaptable for use with thetreatment system 100 are described in, e.g., U.S. Pat. No. 8,834,547 and commonly assigned U.S. Pat. No. 7,854,754 and U.S. Patent Publication Nos. 2008/0077201, 2008/0077211, and 2008/0287839, which are incorporated by reference in their entireties. - In further embodiments, the
system 100 may also include a patient protection device (not shown) incorporated into or configured for use with theapplicator 104 that prevents the applicator from directly contacting a patient's skin and thereby reduces the likelihood of cross-contamination between patients and minimizes cleaning requirements for the applicator. The patient protection device may also include or incorporate various storage, computing, and communications devices, such as a radio frequency identification (RFID) component, to monitor and/or meter use. Exemplary patient protection devices are described in commonly assigned U.S. Patent Publication No. 2008/0077201. - In operation, and upon receiving input to start a treatment protocol, the
controller 114 can cycle through each segment of a prescribed treatment plan. In so doing,power supply 110 andchiller unit 106 can provide power and coolant to one or more functional components of theapplicator 104, such as thermoelectric coolers (e.g., TEC “zones”), to begin a cooling cycle and, in some embodiments, activate features or modes such as vibration, massage, vacuum, etc. Thecontroller 114 can monitor treatment by receiving temperature readings from temperature sensors. The temperature sensors can be part of theapplicator 104 or proximate to theapplicator 104, the patient's skin, a patient protection device, etc. It will be appreciated that while a target region of the body has been cooled or heated to the target temperature, in actuality that region of the body may be close but not equal to the target temperature, e.g., because of the body's natural heating and cooling variations. Thus, although thesystem 100 may attempt to heat or cool tissue to the target temperature or to provide a target heat flux, a sensor may measure a sufficiently close temperature or heat flux. If the target temperature or flux has not been reached, power can be increased or decreased to change heat flux to maintain the target temperature or “set-point” selectively to affect targeted tissue. Thesystem 100 can thus monitor the treatment site while accurately cooling/heating to perform the methods disclosed herein. - The
applicator 104 can damage, injure, disrupt or otherwise reduce subcutaneous lipid-rich cells generally without collateral damage to non-lipid-rich cells in the treatment region. In other embodiments, theapplicator 104 damages, injures, disrupts, or otherwise reduces cells in the epidermal and/or dermal layers to create freeze events (e.g., thermal injuries and/or trauma for achieving desired effects). A cryoprotectant can be administered topically to the skin of the subject 101 at the treatment site and/or used with theapplicator 104 to, among other advantages, assist in preventing or, in other embodiments, controlling freezing of targeted cells. Supercooling or other techniques can be performed without the use of topically applied cryoprotectants. -
FIGS. 3 to 7 are flow diagrams illustrating methods for treating treatment sites in accordance with embodiments of the technology. Although specific example methods are described herein, one skilled in the art is capable of identifying other methods that the system could perform. Moreover, the methods described herein can be altered in various ways. Even though the methods are described with reference to thetreatment system 100 ofFIG. 2 , the methods may also be applied in other treatment systems with additional or different hardware and/or software components. -
FIG. 3 is a flow diagram illustrating amethod 140 for reducing irregularities in a surface of a subject's skin resulting from an uneven distribution of adipose tissue in the subcutaneous layer in accordance with embodiments of the technology. As shown inFIG. 3 , an early stage of themethod 140 can include coupling a heat-exchanging surface of a treatment device with the surface of the subject's skin at a target region (block 142).FIG. 1B shows the heat-exchangingsurface 19 in the form of an exposed surface of a heat-exchanging plate thermally coupled to the subject's skin. In another embodiment, the heat-exchanging surface can be the surface of an interface layer or a dielectric layer. Coupling of heat-exchanging surfaces to the skin can be facilitated by using restraining means, such as a belt or strap. In other embodiments, a vacuum or suction force can be used to positively couple the treatment device to the patient's skin. In some methods, a conductive substance can couple the heat-exchangingsurface 19 to the patient's skin and can be a cryoprotectant. Cryoprotectants and methods of using cryoprotectants are described in commonly assigned U.S. Patent Publication No. 2007/0255362. - At
block 144, themethod 140 includes removing heat such that lipid-rich cells in the subcutaneous layer are reduced in number and/or size to an extent while non-lipid-rich cells and lipid-rich regions adjacent to the fibrous septae are not reduced in number or size to the same extent. For example, cooling the subcutaneous layer in the target region can include cooling the lipid-rich tissue to a temperature below, for example, about 10° C., 0° C., −5° C., −10° C., −15° C., −20° C., −25° C., −30° C., −35° C., or −40° C. to disrupt lipid-rich lobules and the adipose cells. The duration of cooling may vary depending on the location of the target region and the degree of cooling required to reduce the number and/or size of the lipid-rich cells, as well as other parameters. -
FIG. 4 is a flow diagram illustrating amethod 150 for reducing the appearance of cellulite in a target area of a subject in accordance with embodiments of the technology. As shown inFIG. 4 , themethod 150 can include coupling a heat-exchanging surface of a treatment device with the surface of the subject's skin at a target region (block 152). In one embodiment, the heat-exchanging surface can be a surface of a heat-exchanging plate. In another embodiment, the heat-exchanging surface can be the surface of an interface layer or a dielectric layer. Atblock 154, themethod 150 includes cooling the subject's skin to induce a freeze wound at the target region and allowing the freeze wound to heal (block 156). As discussed above, freezing and thawing events can induce injury to the skin tissue. Such injury can promote natural body responses (e.g., healing) that can have positive effects on skin appearance. For example, and in one embodiment, the method can promote thickening of the epidermal layer to reduce the appearance of cellulite. -
FIG. 5 is a flow diagram illustrating amethod 160 for improving the appearance of skin by producing one or more freeze events in accordance with embodiments of the technology. Generally, a treatment device can be applied to a subject and can cool a surface of the subject's skin to produce and detect a freeze event. After detecting the freeze event (or events), operation of the treatment device can be controlled to keep at least a portion of the subject's tissue frozen for a sufficient length of time to improve skin appearance. Details ofmethod 160 are discussed below. - At
block 162, the treatment device is applied to a subject by placing its heat-exchanging surface in thermal contact with the subject's skin. A substance can be applied to the subject's skin before applying the treatment device and can (a) provide thermal coupling between the subject's skin and the treatment device to improve heat transfer therebetween, (b) selectively protect non-target tissues from freeze damage (e.g., damage due to crystallization), and/or (c) initiate and/or control freeze events. The substance may be a fluid, a gel, or a paste and may be hygroscopic, thermally conductive, and biocompatible. In some embodiments, the substance can be a cryoprotectant that reduces or inhibits cell destruction. As used herein, “cryoprotectant,” “cryoprotectant agent,” and “composition” mean substances (e.g., compositions, formulations, compounds, etc.) that assist in preventing freezing of tissue compared to an absence of the substances(s). In one embodiment, the cryoprotectant allows, for example, the treatment device to be pre-cooled prior to being applied to the subject for more efficient treatment. Further, the cryoprotectant can also enable the treatment device to be maintained at a desired low temperature while preventing ice formation on the cooled surface of the treatment device, and thus reduces the delay in reapplying the treatment device to the subject. Yet another aspect of the technology is the cryoprotectant may prevent the treatment device from freezing to the subject's skin. Certain cryoprotectant can allow microscopic crystals to form in the tissue but can limit crystal growth that would cause cell destruction and, in some embodiments, allows for enhanced uptake or absorption and/or retention in target tissue prior to and during cooling. - Some embodiments according to the present technology may use a cryoprotectant with a freezing point depressant that can assist in preventing freeze damage that would destroy cells. Suitable cryoprotectants and processes for implementing cryoprotectants are described in commonly-assigned U.S. Patent Publication No. 2007/0255362. The cryoprotectant may additionally include a thickening agent, a pH buffer, a humectant, a surfactant, and/or other additives and adjuvants as described herein. Freezing point depressants may include, for example, propylene glycol (PG), polyethylene glycol (PEG), dimethyl sulfoxide (DMSO), or other suitable alcohol compounds. In a particular embodiment, a cryoprotectant may include about 30% propylene glycol, about 30% glycerin (a humectant), and about 40% ethanol. In another embodiment, the cryoprotectant may include about 40% propylene glycol, about 0.8% hydroxyethyl cellulose (a thickening agent), and about 59.2% water. In a further embodiment, a cryoprotectant may include about 50% polypropylene glycol, about 40% glycerin, and about 10% ethanol. The freezing point depressant may also include ethanol, propanol, iso-propanol, butanol, and/or other suitable alcohol compounds. Certain freezing point depressants (e.g., PG, PPG, PEG, etc.) may also be used to improve spreadability of the cryoprotectant and to provide lubrication. The freezing point depressant may lower the freezing point of body liquids/lipids to about 0° C. to −50° C., about 0° C. to −50° C., or about 0° C. to −30° C. In other embodiments, the freezing point of the liquid/lipids can be lowered to about −10° C. to about −40° C., about −10° C. to about −30° C., or about −10° C. to about −20° C. In certain embodiments, the freezing point of the liquid/lipids can be lowered to a temperature below about 0° C., below about −5° C., below about −10° C., below about −12° C., below about −15° C., below about −20° C., below about −30° C., or below about −35° C. For example, the freezing point depressant may lower the freezing point of body fluid/lipids to a temperature of between about −1° C. and −40° C., between about −5° C. and −40° C., or between about −10 and −40° C.
- Cryoprotectant can be delivered to the surface of the patient's skin for a period of time which is short enough to not significantly inhibit the initiation of the freeze event in dermal tissue but which is long enough to provide substantial protection to non-targeted tissue (e.g., subcutaneous adipose tissue). The rate of cryoprotectant delivery can be selected based on the characteristics of the cryoprotectant and the desired amount of tissue protection. In one specific treatment process, an interface member is placed directly over the target area, and the treatment device with a disposable sleeve or liner is placed in contact with the interface member. The interface member can be a cotton pad, a gauze pad, a pouch, or a container with a reservoir containing a volume of cryoprotectant or other flowable conductive substance. The interface member can include, for example, a non-woven cotton fabric pad saturated with cryoprotectant that is delivered at a desired delivery rate. Suitable pads include Webril™ pads manufactured by Covidien of Mansfield, Mass. Further details regarding interface members and associated systems and methods of use are described in commonly-assigned U.S. Patent Publication No. 2010/0280582.
- At
block 164, the treatment device can rapidly cool the surface of the patient's skin to a sufficiently low temperature to cause a freeze event in targeted tissue. The rapid cooling can create a thermal gradient with the coldest temperatures near the applicator (e.g., the upper layers of skin). The resulting thermal gradient causes the temperature of the upper layer(s) of the skin to be lower than that of the targeted deeper cells. This allows the skin to be frozen for a short enough duration to not establish a temperature equilibrium across the skin and adjacent subcutaneous tissue. A cryoprotectant and/or warming cycle can be used to inhibit freezing the uppermost non-targeted layer or layers of skin. - A freeze event can include at least some crystallization (e.g., formation of microscopic ice crystals) in intercellular material (e.g., fluid, cell components, etc.) and/or extracellular fluid. By avoiding extensive ice crystal formation that would cause frostbite or necrosis, partial freeze events can occur without undesired tissue damage. In some embodiments, the surface of the patient's skin can be cooled to a temperature no lower than about −40° C., −30° C., −20° C., −10° C., or −5° C. to produce a partial or total freeze event without causing irreversible skin damage. In one example, the
treatment system 100 ofFIG. 2 can cool the surface of the skin to from about −40° C. to about 0° C., from about −30° C. to about 0° C., from about −20° C. to about 0° C., or from about −15° C. to about 0° C. or below about −10° C., −20° C., −20° C., −30° C., or −40° C. It will be appreciated that the surface of skin can be cooled to other temperatures based on the mechanism of action. - The cooling period can be sufficiently short to minimize, limit, or substantially eliminate necrosis, or other unwanted thermal damage, due to the freeze event. In one procedure, the applicator (e.g.,
applicator 104 ofFIGS. 1B and 2 ) can produce a freeze event that begins within a predetermined period of time after the applicator begins cooling the patient's skin or after the freeze event begins. The predetermined period of time can be equal to or shorter than about 30, 60, 90, 120, or 150 seconds and, in some embodiments, the predetermined period of time can be from between about 10 seconds to about 150 seconds, between about 30 seconds to about 150 seconds, or between about 60 seconds to about 150 seconds. In some embodiments, the predetermined period of time can be shorter than about either 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 minutes. A controller (e.g.,controller 114 ofFIG. 2 ) can select the predetermined period of time based on the treatment temperatures, treatment sites, and/or cryotherapy to be performed. Alternatively, an operator can select the period of time for cooling and can enter it into thecontroller 114. - To help initiate the freeze event (e.g., the partial or total freeze event), energy, pressure, and/or a substance can be used to aid in the formation of nucleation sites for crystallization. Energy for promoting nucleation can include, without limitation, acoustic energy (e.g., ultrasound energy), mechanical energy (e.g., vibratory motion, massaging, and/or pulsatile forces), or other suitable energy. The applicators disclosed herein can include, without limitation, one or more elements (e.g.,
elements 171 inFIG. 1B ) in the form of actuators (e.g., motors with eccentric weights), vibratory motors, hydraulic motors, electric motors, AC electrodes, pneumatic motors, solenoids, piezoelectric shakers, and so on for providing energy, pressure, etc. Pressure for promoting nucleation can be applied uniformly or non-uniformly across the treatment site. Substances that promote nucleation can be applied topically before and/or during skin cooling. - At
block 166 ofFIG. 5 , the treatment device can detect the freeze event using one or more electrical components.FIG. 1B shows theapplicator 104 with an electronic component in the form of asensor 167 that can identify positive (increase) or negative (decrease) temperature changes. During cooling, targeted tissue can reach a temperature below the freezing point of its biological tissue and fluids (e.g., approximately −1.8° C.). As tissue, fluids, and lipids freeze, crystals can form and energy associated with the latent heat of crystallization is released. A relatively small positive change in tissue temperature can indicate a partial freeze event whereas a relatively large positive change in tissue temperature can indicate a complete freeze event. The sensor 167 (FIG. 1B ) can detect the positive change in tissue temperature, and the treatment system can identify it as a freeze event. The treatment system can be programmed so that small temperature variations do not cause false alarms with respect to false treatment events. Additionally or alternatively, the treatment systems disclosed herein may detect changes in the temperature of its components or changes in power supplied to treatment devices, or other components, to identify freeze events. - Referring now to
FIG. 2 , thesystem 100 can monitor the location and/or movement of theapplicator 104 and may prevent false or inaccurate determinations of treatment events based on such monitoring. Theapplicator 104 may move during treatment which may cause theapplicator 104 to contact a warmer area of skin, to no longer contact the skin, and so on. This may cause thesystem 100 to register a difference in temperature that is inconsistent with a normal treatment. Thecontroller 114 may be programmed to differentiate between these types of temperature increases and a temperature increase associated with freezing. U.S. Pat. No. 8,285,390 discloses techniques for monitoring and detecting freeze events and applicator movement and is incorporated by reference in its entirety. Additionally, thetreatment system 100 can provide an indication or alarm to alert the operator to the source of this temperature increase. In the case of a temperature increase not associated with a treatment event, thesystem 100 may also suppress false indications, while in the case of a temperature increase associated with freezing, thesystem 100 take any number of actions based on that detection as described elsewhere herein. - The
system 100 can use optical techniques to detect events atblock 166 ofFIG. 5 . For example, thesensor 167 ofFIG. 1B can be an optical sensor capable of detecting changes in the optical characteristics of tissue caused by freezing. The optical sensor can include one or more energy emitters (e.g., light sources, light emitting diodes, etc.), detector elements (e.g., light detectors), or other components for non-invasively monitoring optical characteristics of tissue. In place of or in conjunction with monitoring using optical techniques, tissue can be monitored using electrical and/or mechanical techniques. In embodiments for measuring electrical impedance of tissue, the sensor 167 (FIG. 1B ) can include two electrodes that can be placed in electrical communication with the skin for monitoring electrical energy traveling between the electrodes via the tissue. In embodiments for measuring mechanical properties of tissue, thesensor 167 can comprise one or more mechanical sensors which can include, without limitation, force sensors, pressure sensors, and so on. - At
block 168 ofFIG. 5 , the treatment device can be controlled to maintain the freeze event by continuously or periodically cooling the patient's tissue to keep a target volume of skin frozen for a period of time, which can be long enough to improve skin appearance. In short treatments, the period of time can be equal to or shorter than about 5, 10, 15, 20, or 25 seconds. In longer treatments, the period of time can be equal to or longer than about 25 seconds, 30 seconds, 45 seconds or 1, 2, 3, 4, 5, or 10 minutes. In some procedures, theapplicator 104 ofFIGS. 1B and 2 can be controlled so that the skin is partially or completely frozen for no longer than, for example, 5 minutes, 10 minutes, 20 minutes, 30 minutes, 45 minutes, or 1 hour. In some examples, the skin is frozen for about 1 minute to about 5 minutes, about 5 minutes to about 10 minutes, about 10 minutes to about 20 minutes, about 20 minutes to about 30 minutes, or about 30 minutes to about 1 hour. The length of time the skin is kept frozen can be selected based on the severity of the freeze injury. - At
block 168, the treatment system can also control the applicator so that the partial or total freeze event causes apoptotic damage to targeted tissue but does not cause such damage to non-targeted tissue. In one example, the applicator produces a partial freeze event short enough to prevent establishing equilibrium temperature gradients in the patient's skin during, for example, the freeze event. This allows freezing of shallow targeted tissue without substantially affecting deeper non-targeted tissue. Moreover, cells in the dermal tissue can be affected to a greater extent than the cells in the subcutaneous layer. In some procedures, the subcutaneous layer can be kept at a sufficiently high temperature (e.g., at or above 0° C.) while the shallower dermal tissue experiences the partial or total freeze event. The system can also control operation of the applicator to thermally injure tissue to cause fibrosis, which increases the amount of connective tissue in a desired tissue layer (e.g., epidermis and/or dermis) to increase the firmness and appearance of the skin. In other treatments, the system controls the applicator to supercool and then freeze (e.g., partially or totally freeze) at least a portion of subcutaneous tissue, such as the fibrous septae. - At
block 169, the patient's partially or completely frozen tissue can be thawed by heating it in order to minimize, reduce, or limit tissue damage. The applicator can thaw the patient's skin, or other frozen tissue, after the freeze event occurs and after a period of time has transpired. The period of time can be equal to or shorter than about 5, 10, 15, 20, or 25 seconds or about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 minutes. In one example, the uppermost skin layer(s) can be periodically heated to a temperature above the skin's freezing point to provide freeze protection thereto. The applicator can include one or more thermal elements (e.g., resistive heaters, electromagnetic energy emitters, Peltier devices, etc.) for heating frozen tissue. For example, theelement 103 ofFIG. 1B can be a Peltier device capable of generating heat for thawing tissue. Alternatively, theapplicator 104 can include one or more resistive heaters orPeltier devices 171 for thawing tissue. In some embodiments, theapplicator 104 ofFIGS. 1B and 2 can have separate and independently controlled cooling elements and heating elements that can cooperate to provide precise temperature control for freezing and thawing/warming cycles. In some embodiments, the applicator may stop cooling tissue to allow cooled tissue to naturally warm and thaw. -
FIGS. 6 and 7 are flow diagrams illustrating methods for supercooling tissue in accordance with embodiments of the technology. Generally, the methods can include treating a human subject's body to cool a surface of the subject's skin to a temperature no lower than −40° C. to avoid unwanted skin damage and so that the temperature of at least a portion of tissue below the surface is in a supercooled state. The surface of the skin can be heated to bring shallow non-targeted tissue out of the supercooled state while deeper targeted tissue remains in the supercooled state. The supercooled targeted tissue can be nucleated due to a perturbation that causes at least partial freezing that destroys or damages targeted cells due to crystallization of intracellular and/or extracellular fluids. The perturbation can be vibrations, ultrasound pulses, and/or changes in pressure suitable for inducing a partial or complete freeze event to disrupt or destroy targeted lipid-rich cells. The treatment system 100 (FIGS. 2 and 8 ) can utilize applicators disclosed herein to perform such supercooling method. -
FIG. 6 is a flow diagram illustrating amethod 400 in accordance with an aspect of the present technology. An early stage of themethod 400 can include cooling a surface of a human subject's skin to a first temperature (block 402). The first temperature can be, for example, between about −10° C. and −40° C. such that a portion of tissue below the surface is in a supercooled state. In other embodiments, the first temperature can be a temperature between about −15° C. and −25° C., a temperature between about −20° C. and about −30° C., or other temperature below a freezing temperature. - In
block 404, the surface of the human subject's skin is heated an amount sufficient to raise the skin surface temperature from the first temperature to a second temperature, which can be a non-supercooled temperature, while the targeted tissue remains in the supercooled state. For example, the treatment system can be used to heat the surface (e.g., the epidermis) of the skin to a temperature higher than about 0° C., higher than about 5° C., higher than about 10° C., higher than about 20° C., higher than about 30° C., or higher than about 35° C. There can be a temperature gradient between the targeted tissue and the skin surface such that most of the non-targeted tissue is at a non-supercooled temperature. - In
block 406, the supercooled portion of tissue below the skin surface can be nucleated to cause at least some fluid and cells in the supercooled tissue to at least partially freeze. In one embodiment, nucleation of the supercooled tissue is caused by a mechanical perturbation. Cells residing at the surface of the human subject's skin do not freeze, and in certain arrangements, protection of cells at the surface can be accomplished without the use of a chemical cryoprotectant. - In
block 408, the supercooled tissue can be maintained in the at least partially or totally frozen state for a predetermined period of time longer than, for example, about 10 seconds, 12 seconds, 15 seconds, or 20 seconds. In various arrangements, the supercooled tissue can be maintained in the at least or totally frozen state for a duration of time sufficient to improve an appearance of skin (e.g., by tightening the skin, increasing skin smoothness, thickening the skin, improving the appearance of cellulite, etc.), treat acne, improve a quality of hair, improve a condition associated with hyperhidrosis, etc. In certain embodiments, the maintaining step can include detecting the temperatures and controlling the cooling and heating to maintain targeted tissue in at least a partially or totally frozen state for the predetermined time (e.g., longer than about 10 seconds, longer than about 12 seconds, longer than about 15 seconds, or longer than about 20 seconds). - In
block 409, the patient's partially or completely frozen tissue can be optionally thawed by heating it in order to minimize, reduce, or limit tissue damage. The applicator can thaw the patient's skin, or other frozen tissue, after the freeze event occurs and after a period of time has transpired. In some embodiments, the applicator may stop cooling tissue to allow cooled tissue to naturally warm and thaw. - The
method 400 can be performed to keep the freeze event localized in the targeted layer. After supercooling tissue, epidermal tissue can be heated to prevent freeze injuries to the epidermal cells. In other embodiments, the freeze event can be centered at the interface between the dermis and the subcutaneous layer or at any other location. Themethod 400 can be repeated any number of times at the same location or different locations along the subject. -
FIG. 7 illustrates amethod 500 for affecting a subcutaneous layer of a human subject's body in accordance with another embodiment of the present technology. Themethod 500 can include transdermally removing heat from tissue at a target region such that cells in the target region are cooled to a supercooled temperature (block 502). The supercooled temperature can be, for example, below about 0° C. or within a range from about 0° C. to about −20° C., from about −10° C. to about −30° C., from about −20° C. to about −40° C., or no lower than about −40° C. Cryoprotectants can be used to cool tissue to very low temperatures, including temperatures lower than −40° C. - In
block 504, themethod 500 includes applying heat to an epidermis of the target region to warm epidermal cells in the target region to a temperature above freezing while lipid-rich cells in the subcutaneous layer of the target region are at or near the supercooled temperature. For example, the step of applying heat can include warming the epidermal cells to a temperature above about 5° C., about 10° C., about 20° C., about 25° C., or about 32° C. - In
bock 506, a freeze event in the subcutaneous layer of the target region can selectively affect the lipid-rich cells while epidermal cells are not affected by the freeze event. Themethod 500 can include providing at least one of vibration, mechanical pressure, and ultrasound pulses to the target region to cause such freeze event. In various arrangements, the freeze event can cause at least partial crystallization of a plurality of lipid-rich cells in the target region. Beneficially, the epidermal cells are protected such that freeze damage to these cells does not occur. In certain embodiments, freeze damage protection of the epidermal tissue can occur without applying a cryoprotectant to the surface of the skin prior to or during the treatment. - In some embodiments, the dermal layer can be supercooled while the subcutaneous layer can remain above its freezing point to avoid affecting the subcutaneous lipid-rich cells. The freeze event can occur in the dermal layer after non-targeted epidermal tissue has been warmed such that freeze induced changes at the target region can be localized in the dermal layer. Thus, dermal cells can be affected without appreciably affecting epidermal and subcutaneous cells. The
method 500 can also be modified to produce freeze events in other layers of tissue. For example, a freeze event can be produced within one or more targeted epidermal layers by supercooling the targeted epidermal layer(s) and then warming the non-targeted epidermal layer(s). The supercooled epidermal layers are then nucleated. - Various aspects of the methods 400 (
FIG. 6) and 500 (FIG. 7 ) can include cosmetic treatment methods for treating the target region of a human subject's body to achieve a cosmetically beneficial alteration of a portion of tissue within the target region. Such cosmetic methods can be administered by a non-medically trained person. The methods disclosed herein can also be used to (a) improve the appearance of skin by tightening the skin, improving skin tone and texture, eliminating or reducing wrinkles, increasing skin smoothness, thickening the skin, (b) improve the appearance of cellulite, and/or (c) treat sebaceous glands, hair follicles, and/or sweat glands. -
FIG. 8 is a partially schematic isometric view of thesystem 100 with amulti-modality applicator 204 positioned along the subject's waist. Thepower supply 110 can provide a direct current voltage to theapplicator 204 to remove heat from the subject 101. Thecontroller 114 can monitor process parameters via sensors (e.g., sensors of theapplicator 204 and/or sensors placed proximate to the applicator 204) via thecontrol line 116 to, among other things, adjust the heat removal rate and/or energy delivery rate based on a custom treatment profile or patient-specific treatment plan, such as those described, for example, in commonly assigned U.S. Pat. No. 8,275,442. - The
controller 114 can exchange data with theapplicator 204 via anelectrical line 112 or, alternatively, via a wireless or an optical communication link. Thecontrol line 116 andelectrical line 112 are shown without any support structure. Alternatively,control line 116 and electrical line 112 (and other lines including, but not limited to fluid lines 108 a-b and power lines 109 a-b) may be bundled into or otherwise accompanied by a conduit or the like to protect such lines, enhance ergonomic comfort, minimize unwanted motion (and thus potential inefficient removal of heat from and/or delivery of energy to subject 101), and to provide an aesthetic appearance to thesystem 100. Examples of such a conduit include a flexible polymeric, fabric, composite sheath, an adjustable arm, etc. Such a conduit (not shown) may be designed (via adjustable joints, etc.) to “set” the conduit in place for the treatment of the subject 101. - The
controller 114 can receive data from an input/output device 120, transmit data to a remote output device (e.g., a computer), and/or exchange data with another device. The input/output device 120 can include a display or touch screen (shown), a printer, video monitor, a medium reader, an audio device such as a speaker, any combination thereof, and any other device or devices suitable for providing user feedback. In the embodiment ofFIG. 8 , the input/output device 120 can be a touch screen that provides both an input and output functionality. Thetreatment tower 102 can include visual indicator devices or controls (e.g., indicator lights, numerical displays, etc.) and/or audio indicator devices or controls. These features can be part of a control panel that may be separate from the input/output device 120, may be integrated with one or more of the devices, may be partially integrated with one or more of the devices, may be in another location, and so on. In alternative examples, input/output device 120 or parts thereof (described herein) may be contained in, attached to, or integrated with theapplicator 204 - The
controller 114,power supply 110,chiller unit 106 with areservoir 105, and input/output device 120 are carried by arack 124 withwheels 126 for portability. In alternative embodiments, thecontroller 114 can be contained in, attached to, or integrated with themulti-modality applicator 204 and/or a patient protection device. In yet other embodiments, the various components can be fixedly installed at a treatment site. Further details with respect to components and/or operation of applicators, treatment tower, and other components may be found in commonly-assigned U.S. Patent Publication No. 2008/0287839. - The
system 100 can include an energy-generatingunit 107 for applying energy to the target region, for example, to further interrogate cooled or heated cells via power-lines 109 a-b. In one embodiment, the energy-generatingunit 107 can be a pulse generator, such as a high voltage or low voltage pulse generator, capable of generating and delivering a high or low voltage current, respectively, through thepower lines applicator 204. In other embodiments, the energy-generatingunit 107 can include a variable powered RF generator capable of generating and delivering RF energy, such as RF pulses, through thepower lines unit 107 can include a microwave pulse generator, an ultrasound pulse laser generator, or high frequency ultrasound (HIFU) phased signal generator, or other energy generator suitable for applying energy. In additional embodiments, thesystem 100 can include more than one energy-generatingunit 107 such as any one of a combination of the energy modality generating units described herein. Systems having energy-generating units and applicators having one or more electrodes are described in commonly assigned U.S. Patent Publication No. 2012/0022518 and U.S. patent application Ser. No. 13/830,413. - The
applicator 204 can include one or more heat-exchanging units. Each heat-exchanging unit can include or be associated with one or more Peltier-type thermoelectric elements, and theapplicator 204 can have multiple individually controlled heat-exchanging zones (e.g., between 1 and 50, between 10 and 45; between 15 and 21, etc.) to create a custom spatial cooling profile and/or a time-varying cooling profile. Each custom treatment profile can include one or more segments, and each segment can include a specified duration, a target temperature, and control parameters for features such as vibration, massage, vacuum, and other treatment modes. Applicators having multiple individually controlled heat-exchanging units are described in commonly assigned U.S. Patent Publication Nos. 2008/0077211 and 2011/0238051. - The
applicator 204 can be applied with pressure or with a vacuum type force to the subject's skin. Pressing against the skin can be advantageous to achieve efficient treatment. In general, the subject 101 has an internal body temperature of about 37° C., and the blood circulation is one mechanism for maintaining a constant body temperature. As a result, blood flow through the tissue to be treated can be viewed as a heat source that counteracts the cooling of the desired targeted tissue. As such, cooling the tissue of interest requires not only removing the heat from such tissue but also that of the blood circulating through this tissue. Thus, temporarily reducing or eliminating blood flow through the treatment region, by means such as, e.g., applying the applicator with pressure, can improve the efficiency of tissue cooling (e.g., tissue cooling to reduce cellulite, wrinkles, sagging skin, loose skin, etc.) and avoid excessive heat loss. Additionally, a vacuum can pull tissue away from the body which can assist in cooling targeted tissue. -
FIG. 9 is a schematic cross-sectional view illustrating a treatment device in the form of anapplicator 200 for non-invasively removing heat from target tissue in accordance with an embodiment of the present technology. Theapplicator 200 can include acooling device 210 and aninterface layer 220. In one embodiment, thecooling device 210 includes one or more thermoelectric elements 213 (e.g., Peltier-type TEC elements) powered by a treatment tower (e.g.,treatment tower 102 ofFIGS. 2 and 8 ). - The
applicator 200 can contain acommunication component 215 that communicates with thecontroller 114 to provide a first sensor reading 242, and asensor 217 that measures, e.g., temperature of thecooling device 210, heat flux across a surface of or plane within thecooling device 210, tissue impedance, application force, tissue characteristics (e.g., optical characteristics), etc. Theinterface layer 220 can be a plate, a film, a covering, a sleeve, a substance reservoir or other suitable element described herein and, in some embodiments, may serve as the patient protection device described herein. - The
interface layer 220 can also contain asimilar communication component 225 that communicates with thecontroller 114 to provide a second sensor reading 244 and asensor 227 that measures, e.g., the skin temperature, temperature of theinterface layer 220, heat flux across a surface of or plane within theinterface layer 220, contact pressure with theskin 230 of the patient, etc. For example, one or both of thecommunication components controller 114, such as temperature and/or heat flux information as determined by one or both ofsensors sensors device 210 and the patient'sskin 230. Theapplicator 200 can also contain components described in connection withFIGS. 2 and 8 . - In certain embodiments, the
applicator 200 can include a sleeve or liner 250 (shown schematically in phantom line) for contacting the patient'sskin 230, for example, to prevent direct contact between theapplicator 200 and the patient'sskin 230, and thereby reduce the likelihood of cross-contamination between patients, minimize cleaning requirements for theapplicator 200, etc. Thesleeve 250 can include afirst sleeve portion 252 and asecond sleeve portion 254 extending from the first sleeve portion. Thefirst sleeve portion 252 can contact and/or facilitate the contact of theapplicator 200 with the patient'sskin 230, while thesecond sleeve portion 254 can be an isolation layer extending from thefirst sleeve portion 252. Thesecond sleeve portion 254 can be constructed from latex, rubber, nylon, Kevlar®, or other substantially impermeable or semi-permeable material. Thesecond sleeve portion 254 can prevent contact between the patient'sskin 230 and thecooling device 210, among other things. Further details regarding a patient protection device may be found in U.S. Patent Publication No. 2008/0077201. - A device (not shown) can assists in maintaining contact between the applicator 200 (such as via an interface layer 220) and the patient's
skin 230. Theapplicator 200 can include a belt or other retention devices (not shown) for holding theapplicator 200 against theskin 230. A belt may be rotatably connected to theapplicator 200 by a plurality of coupling elements that can be, for example, pins, ball joints, bearings, or other type of rotatable joints. Alternatively, retention devices can be rigidly affixed to the end portions of theinterface layer 220. Further details regarding suitable belt devices or retention devices may be found in U.S. Patent Publication No. 2008/0077211. - A vacuum can assist in providing contact between the applicator 200 (such as via the
interface layer 220 or sleeve 250) and the patient'sskin 230. Theapplicator 200 can provide mechanical energy to a treatment region using the vacuum. Imparting mechanical vibratory energy to the patient's tissue by repeatedly applying and releasing (or reducing) the vacuum, for instance, creates a massage action during treatment. Further details regarding vacuums and vacuum type devices may be found in U.S. Patent Application Publication No. 2008/0287839. - Optionally, the
applicator 200 can include one or more features used with supercooling. For example, theinterface layer 220 can include one ormore nucleation elements nucleation elements FIG. 8 ) of thetreatment tower 102 can include an RF generator for driving thenucleation elements nucleation elements interface layer 220 or other components of theapplicator 200 to provide the ability to controllably nucleate supercooled tissue. - Although the
thermoelectric elements 213 can heat tissue, theapplicator 200 can also include dedicated heating elements used to, for example, thaw tissue. Theinterface layer 220 or other components of theapplicator 200 can include one ormore heaters 235 for generating heat delivered to the surface of theskin 230. Theheaters 235 can be resistive heaters, Peltier devices, or other thermoelectric elements capable of generating heat. Optionally, thenucleation elements skin 230. For example, thenucleation elements skin 230 or deeper tissue. -
FIGS. 10A to 10C illustrate treatment devices suitable for use with the treatment systems in accordance with embodiments of the technology.FIG. 10A is a schematic, cross-sectional view illustrating anapplicator 260 for non-invasively removing heat from target areas of a subject 262. Theapplicator 260 can include a heat-exchanging unit or cooling device, such as a heat-exchanging plate 264 (shown in phantom line) and an interface layer 265 (shown in phantom line). Theinterface layer 265 can have a rigid or compliantconcave surface 267. When theapplicator 260 is held against the subject, the subject's tissue can be pressed against thecurved surface 267. One or more vacuum ports can be positioned along thesurface 267 to draw theskin 262 against thesurface 267. The configuration (e.g., dimensions, curvature, etc.) of theapplicator 260 can be selected based on the treatment site. -
FIG. 10B is a schematic, cross-sectional view illustrating anapplicator 270 that includes a heat-exchangingunit 274 having a rigid or compliantconvex surface 276 configured to be applied to concave regions of the subject. Advantageously, theconvex surface 276 can spread tissue to reduce the distance between theconvex surface 276 and targeted tissue under theconvex surface 276. -
FIG. 10C is a schematic, cross-sectional view illustrating anapplicator 280 including asurface 282 movable between aplanar configuration 284 and a non-planar configuration 285 (shown in phantom). Thesurface 282 is capable of conforming to the treatment site to provide a large contact area. In some embodiments, thesurface 282 can be sufficiently compliant to conform to highly contoured regions of a subject's face when theapplicator 280 is pressed against facial tissue. In other embodiments, theapplicator 280 can include actuators or other devices configured to move thesurface 282 to a concave configuration, a convex configuration, or the like. Thesurface 282 can be reconfigured to treat different treatment sites of the same subject or multiple subjects. -
FIG. 11 is a schematic, cross-sectional view of anapplicator 300 for non-invasively removing heat from target areas in accordance with another embodiment of the technology. Theapplicator 300 includes ahousing 301 having avacuum cup 302 with avacuum port 304 disposed in thevacuum cup 302. Thehousing 301 is coupled to or otherwise supports afirst applicator unit 310 a on one side of thecup 302, and asecond applicator unit 310 b on an opposing side of thecup 302. Each of the first andsecond applicator units FIGS. 2 and 6 ). As such, the heat-exchangingplates cooling device 210 described above with reference toFIG. 9 . - The interface layers 314 a and 314 b are adjacent to the heat-exchanging
plates interface layer 220 illustrated inFIG. 9 , the interface layers 314 a and 314 b can be plates, films, a covering, a sleeve, a reservoir or other suitable element located between the heat-exchangingplates interface layer 220 ofFIG. 9 for communicating with thecontroller 114. In other embodiments, the interface layers 314 can be eliminated. - In operation, a
rim 316 of thevacuum cup 302 is placed against the skin of a subject and a vacuum is drawn within thecup 302. The vacuum pulls the tissue of the subject into thecup 302 and coapts the target area with the interface layers 314 a and 314 b of the corresponding first andsecond applicator units suitable vacuum cup 302 with cooling units is described in U.S. Pat. No. 7,367,341. The vacuum can stretch or otherwise mechanically challenge skin. Applying theapplicator 300 with pressure or with a vacuum type force to the subject's skin or pressing against the skin can be advantageous to achieve efficient treatment. The vacuum can be used to damage (e.g., via mechanically massage) and/or stretch connective tissue, thereby lengthen the connective tissue. In general, the subject has an internal body temperature of about 37° C., and the blood circulation is one mechanism for maintaining a constant body temperature. As a result, blood flow through the skin and subcutaneous layer of the region to be treated can be viewed as a heat source that counteracts the cooling of the desired targeted tissue. As such, cooling the tissue of interest requires not only removing the heat from such tissue but also that of the blood circulating through this tissue. Temporarily reducing or eliminating blood flow through the treatment region, by means such as, e.g., applying the applicator with pressure, can improve the efficiency of tissue cooling and avoid excessive heat loss through the dermis and epidermis. Additionally, a vacuum can pull skin away from the body which can assist in cooling targeted tissue. - The
units controller 114 ofFIGS. 2 and 8 ), and a supply such that the heat-exchangingplates plates plates plates -
FIG. 12 is a schematic block diagram illustrating subcomponents of acomputing device 700 suitable for thesystem 100 ofFIGS. 2 and 8 in accordance with an embodiment of the disclosure. Thecomputing device 700 can include aprocessor 701, a memory 702 (e.g., SRAM, DRAM, flash, or other memory devices), input/output devices 703, and/or subsystems andother components 704. Thecomputing device 700 can perform any of a wide variety of computing processing, storage, sensing, imaging, and/or other functions. Components of thecomputing device 700 may be housed in a single unit or distributed over multiple, interconnected units (e.g., though a communications network). The components of thecomputing device 700 can accordingly include local and/or remote memory storage devices and any of a wide variety of computer-readable media. - As illustrated in
FIG. 12 , theprocessor 701 can include a plurality offunctional modules 706, such as software modules, for execution by theprocessor 701. The various implementations of source code (i.e., in a conventional programming language) can be stored on a computer-readable storage medium or can be embodied on a transmission medium in a carrier wave. Themodules 706 of the processor can include aninput module 708, adatabase module 710, aprocess module 712, anoutput module 714, and, optionally, adisplay module 716. - In operation, the
input module 708 accepts anoperator input 719 via the one or more input/output devices described above with respect toFIG. 6 , and communicates the accepted information or selections to other components for further processing. Thedatabase module 710 organizes records, including patient records, treatment data sets, treatment profiles and operating records and other operator activities, and facilitates storing and retrieving of these records to and from a data storage device (e.g.,internal memory 702, an external database, etc.). Any type of database organization can be utilized, including a flat file system, hierarchical database, relational database, distributed database, etc. - In the illustrated example, the
process module 712 can generate control variables based onsensor readings 718 from sensors (e.g.,sensor 167 ofFIG. 1B , thetemperature measurement components FIG. 9 , etc.) and/or other data sources, and theoutput module 714 can communicate operator input to external computing devices and control variables to the controller 114 (FIGS. 2 , 8, and 9). The display module 816 can be configured to convert and transmit processing parameters, sensor readings 818, output signals 720, input data, treatment profiles and prescribed operational parameters through one or more connected display devices, such as a display screen, printer, speaker system, etc. Asuitable display module 716 may include a video driver that enables thecontroller 114 to display thesensor readings 718 or other status of treatment progression (FIGS. 2 and 8 ). - In various embodiments, the
processor 701 can be a standard central processing unit or a secure processor. Secure processors can be special-purpose processors (e.g., reduced instruction set processor) that can withstand sophisticated attacks that attempt to extract data or programming logic. The secure processors may not have debugging pins that enable an external debugger to monitor the secure processor's execution or registers. In other embodiments, the system may employ a secure field programmable gate array, a smartcard, or other secure devices. - The
memory 702 can be standard memory, secure memory, or a combination of both memory types. By employing a secure processor and/or secure memory, the system can ensure that data and instructions are both highly secure and sensitive operations such as decryption are shielded from observation. Thememory 702 can contain executable instruction for cooling the surface of the subject's skin to a temperature and controlling treatment devices in response to, for example, detection of a or total freeze event. Thememory 702 can include thawing instructions that, when executed, causes the controller to control the applicator to heat tissue. In some embodiments, thememory 702 stores instructions that can be executed to control the applicators to perform the methods disclosed herein without causing undesired effects, such as significantly lightening or darkening skin one of more days after the freeze event ends. The instructions and treatment programs can be modified based on patient information, treatments to be performed, or other treatment parameters. The instructions can be executed to perform the methods disclosed herein. - Suitable computing environments and other computing devices and user interfaces are described in commonly assigned U.S. Pat. No. 8,275,442, entitled “TREATMENT PLANNING SYSTEMS AND METHODS FOR BODY CONTOURING APPLICATIONS,” which is incorporated herein in its entirety by reference.
- It will be appreciated that some well-known structures or functions may not be shown or described in detail, so as to avoid unnecessarily obscuring the relevant description of the various embodiments. Although some embodiments may be within the scope of the technology, they may not be described in detail with respect to the Figures. Furthermore, features, structures, or characteristics of various embodiments may be combined in any suitable manner. The technology disclosed herein can be used for improving the appearance of skin and to perform the procedures disclosure in U.S. Provisional Application Ser. No. 61/943,250, filed Feb. 21, 2014, U.S. Pat. No. 7,367,341 entitled “METHODS AND DEVICES FOR SELECTIVE DISRUPTION OF FATTY TISSUE BY CONTROLLED COOLING” to Anderson et al., and U.S. patent Publication No. US 2005/0251120 entitled “METHODS AND DEVICES FOR DETECTION AND CONTROL OF SELECTIVE DISRUPTION OF FATTY TISSUE BY CONTROLLED COOLING” to Anderson et al., the disclosures of which are incorporated herein by reference in their entireties. The technology disclosed herein can target tissue for tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness as disclosed in U.S. Provisional Application Ser. No. 61/943,250.
- Unless the context clearly requires otherwise, throughout the description, the words “comprise,” “comprising,” and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in a sense of “including, but not limited to.” Words using the singular or plural number also include the plural or singular number, respectively. Use of the word “or” in reference to a list of two or more items covers all of the following interpretations of the word: any of the items in the list, all of the items in the list, and any combination of the items in the list. In those instances where a convention analogous to “at least one of A, B, and C, etc.” is used, in general such a construction is intended in the sense of the convention (e.g., “a system having at least one of A, B, and C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.). In those instances where a convention analogous to “at least one of A, B, or C, etc.” is used, in general such a construction is intended in the sense of the convention (e.g., “a system having at least one of A, B, or C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.).
- Any patents, applications and other references, including any that may be listed in accompanying filing papers, are incorporated herein by reference. Aspects of the described technology can be modified, if necessary, to employ the systems, functions, and concepts of the various references described above to provide yet further embodiments. While the above description details certain embodiments and describes the best mode contemplated, no matter how detailed, various changes can be made. Implementation details may vary considerably, while still being encompassed by the technology disclosed herein. The various aspects and embodiments disclosed herein are for purposes of illustration and are not intended to be limiting, with the true scope and spirit being indicated by the following claims.
Claims (42)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/611,052 US20150216719A1 (en) | 2014-01-31 | 2015-01-30 | Treatment systems and methods for treating cellulite and for providing other treatments |
US16/227,376 US20190142493A1 (en) | 2014-01-31 | 2018-12-20 | Treatment systems and methods for treating cellulite and for providing other treatments |
US17/719,661 US20220387091A1 (en) | 2014-01-31 | 2022-04-13 | Treatment systems and methods for treating cellulite and for providing other treatments |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461934549P | 2014-01-31 | 2014-01-31 | |
US201461943257P | 2014-02-21 | 2014-02-21 | |
US201461943250P | 2014-02-21 | 2014-02-21 | |
US14/611,052 US20150216719A1 (en) | 2014-01-31 | 2015-01-30 | Treatment systems and methods for treating cellulite and for providing other treatments |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/227,376 Continuation US20190142493A1 (en) | 2014-01-31 | 2018-12-20 | Treatment systems and methods for treating cellulite and for providing other treatments |
Publications (1)
Publication Number | Publication Date |
---|---|
US20150216719A1 true US20150216719A1 (en) | 2015-08-06 |
Family
ID=52469360
Family Applications (12)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/115,503 Active 2036-10-17 US10575890B2 (en) | 2014-01-31 | 2015-01-30 | Treatment systems and methods for affecting glands and other targeted structures |
US14/611,127 Active 2036-10-07 US10201380B2 (en) | 2014-01-31 | 2015-01-30 | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US14/610,807 Active US9861421B2 (en) | 2014-01-31 | 2015-01-30 | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US14/611,052 Abandoned US20150216719A1 (en) | 2014-01-31 | 2015-01-30 | Treatment systems and methods for treating cellulite and for providing other treatments |
US15/833,329 Active 2036-12-03 US10912599B2 (en) | 2014-01-31 | 2017-12-06 | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US16/227,376 Abandoned US20190142493A1 (en) | 2014-01-31 | 2018-12-20 | Treatment systems and methods for treating cellulite and for providing other treatments |
US16/233,951 Active US10806500B2 (en) | 2014-01-31 | 2018-12-27 | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US16/736,672 Abandoned US20200138501A1 (en) | 2014-01-31 | 2020-01-07 | Treatment systems and methods for affecting glands and other targeted structures |
US17/072,020 Abandoned US20210038278A1 (en) | 2014-01-31 | 2020-10-15 | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US17/143,163 Active 2035-11-07 US11819257B2 (en) | 2014-01-31 | 2021-01-07 | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US17/719,661 Abandoned US20220387091A1 (en) | 2014-01-31 | 2022-04-13 | Treatment systems and methods for treating cellulite and for providing other treatments |
US18/143,555 Pending US20240000492A1 (en) | 2014-01-31 | 2023-05-04 | Treatment systems and methods for affecting glands and other targeted structures |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/115,503 Active 2036-10-17 US10575890B2 (en) | 2014-01-31 | 2015-01-30 | Treatment systems and methods for affecting glands and other targeted structures |
US14/611,127 Active 2036-10-07 US10201380B2 (en) | 2014-01-31 | 2015-01-30 | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US14/610,807 Active US9861421B2 (en) | 2014-01-31 | 2015-01-30 | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
Family Applications After (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/833,329 Active 2036-12-03 US10912599B2 (en) | 2014-01-31 | 2017-12-06 | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US16/227,376 Abandoned US20190142493A1 (en) | 2014-01-31 | 2018-12-20 | Treatment systems and methods for treating cellulite and for providing other treatments |
US16/233,951 Active US10806500B2 (en) | 2014-01-31 | 2018-12-27 | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US16/736,672 Abandoned US20200138501A1 (en) | 2014-01-31 | 2020-01-07 | Treatment systems and methods for affecting glands and other targeted structures |
US17/072,020 Abandoned US20210038278A1 (en) | 2014-01-31 | 2020-10-15 | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US17/143,163 Active 2035-11-07 US11819257B2 (en) | 2014-01-31 | 2021-01-07 | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US17/719,661 Abandoned US20220387091A1 (en) | 2014-01-31 | 2022-04-13 | Treatment systems and methods for treating cellulite and for providing other treatments |
US18/143,555 Pending US20240000492A1 (en) | 2014-01-31 | 2023-05-04 | Treatment systems and methods for affecting glands and other targeted structures |
Country Status (3)
Country | Link |
---|---|
US (12) | US10575890B2 (en) |
EP (5) | EP3099260A2 (en) |
WO (4) | WO2015117032A1 (en) |
Cited By (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150216720A1 (en) * | 2014-01-31 | 2015-08-06 | Zeltiq Aesthetics, Inc. | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
CN105169574A (en) * | 2015-09-30 | 2015-12-23 | 何燕岳 | Ultrasonic wave coolsculpting device |
US9314368B2 (en) | 2010-01-25 | 2016-04-19 | Zeltiq Aesthetics, Inc. | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods |
US9408745B2 (en) | 2007-08-21 | 2016-08-09 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
US20160317827A1 (en) * | 2015-04-28 | 2016-11-03 | Btl Holdings Limited | Combination of radiofrequency and magnetic treatment methods |
US9545523B2 (en) | 2013-03-14 | 2017-01-17 | Zeltiq Aesthetics, Inc. | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue |
USD777338S1 (en) | 2014-03-20 | 2017-01-24 | Zeltiq Aesthetics, Inc. | Cryotherapy applicator for cooling tissue |
US20170065323A1 (en) * | 2015-09-04 | 2017-03-09 | R2 Dermatology, Inc. | Medical Systems, Methods, and Devices for Hypopigmentation Cooling Treatments |
US20170079833A1 (en) * | 2015-09-21 | 2017-03-23 | Zeltiq Aesthestics, Inc. | Transcutaneous treatment systems, cooling devices, and methods for cooling nerves |
WO2017070112A1 (en) | 2015-10-19 | 2017-04-27 | Zeltiq Aesthetics, Inc. | Vascular treatment systems, cooling devices, and methods for cooling vascular structures |
US9655770B2 (en) | 2007-07-13 | 2017-05-23 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
US9737434B2 (en) | 2008-12-17 | 2017-08-22 | Zeltiq Aestehtics, Inc. | Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells |
WO2017196548A1 (en) | 2016-05-10 | 2017-11-16 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
US9844460B2 (en) | 2013-03-14 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same |
US20180001106A1 (en) | 2016-07-01 | 2018-01-04 | Btl Holdings Limited | Aesthetic method of biological structure treatment by magnetic field |
US9861520B2 (en) | 2009-04-30 | 2018-01-09 | Zeltiq Aesthetics, Inc. | Device, system and method of removing heat from subcutaneous lipid-rich cells |
US9937358B2 (en) | 2015-07-01 | 2018-04-10 | Btl Holdings Limited | Aesthetic methods of biological structure treatment by magnetic field |
US9974519B1 (en) | 2015-07-01 | 2018-05-22 | Btl Holdings Limited | Aesthetic method of biologoical structure treatment by magnetic field |
WO2018111068A1 (en) * | 2016-12-15 | 2018-06-21 | Castro Baldenebro Brayan Gamaniel | System for treating skin lesions caused by acne by means of thermal shocks |
WO2018111069A1 (en) * | 2016-12-15 | 2018-06-21 | Castro Baldenebro Brayan Gamaniel | Method for identifying skin lesions caused by acne by means of multispectral-image capture with prior cooling |
WO2018175111A1 (en) | 2017-03-21 | 2018-09-27 | Zeltiq Aesthetics, Inc. | Use of saccharides for cryoprotection and related technology |
US10092346B2 (en) | 2010-07-20 | 2018-10-09 | Zeltiq Aesthetics, Inc. | Combined modality treatment systems, methods and apparatus for body contouring applications |
CN109310460A (en) * | 2016-06-03 | 2019-02-05 | R2皮肤科有限公司 | Cooling system and skin processing method |
US10245439B1 (en) | 2015-07-01 | 2019-04-02 | Medical Technologies Cz A.S. | Aesthetic method of biological structure treatment by magnetic field |
US10292859B2 (en) | 2006-09-26 | 2019-05-21 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
US10383787B2 (en) | 2007-05-18 | 2019-08-20 | Zeltiq Aesthetics, Inc. | Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue |
US10471269B1 (en) | 2015-07-01 | 2019-11-12 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10478634B2 (en) | 2015-07-01 | 2019-11-19 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10478633B2 (en) | 2015-07-01 | 2019-11-19 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10493293B2 (en) | 2015-07-01 | 2019-12-03 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10524956B2 (en) | 2016-01-07 | 2020-01-07 | Zeltiq Aesthetics, Inc. | Temperature-dependent adhesion between applicator and skin during cooling of tissue |
WO2020023412A1 (en) * | 2018-07-23 | 2020-01-30 | Nc8, Inc. | Cellulite treatment system and methods |
WO2020023406A1 (en) * | 2018-07-23 | 2020-01-30 | Nc8, Inc. | Cellulite treatment system and methods |
US10549109B2 (en) | 2015-07-01 | 2020-02-04 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10549110B1 (en) | 2015-07-01 | 2020-02-04 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
WO2020028472A1 (en) * | 2018-07-31 | 2020-02-06 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
US10556122B1 (en) | 2016-07-01 | 2020-02-11 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10555831B2 (en) | 2016-05-10 | 2020-02-11 | Zeltiq Aesthetics, Inc. | Hydrogel substances and methods of cryotherapy |
US10568759B2 (en) | 2014-08-19 | 2020-02-25 | Zeltiq Aesthetics, Inc. | Treatment systems, small volume applicators, and methods for treating submental tissue |
US10569094B2 (en) | 2015-07-01 | 2020-02-25 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10569095B1 (en) | 2015-07-01 | 2020-02-25 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10675176B1 (en) | 2014-03-19 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Treatment systems, devices, and methods for cooling targeted tissue |
US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
US10695575B1 (en) | 2016-05-10 | 2020-06-30 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10695576B2 (en) | 2015-07-01 | 2020-06-30 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10709894B2 (en) | 2015-07-01 | 2020-07-14 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10709895B2 (en) | 2016-05-10 | 2020-07-14 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10722395B2 (en) | 2011-01-25 | 2020-07-28 | Zeltiq Aesthetics, Inc. | Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells |
WO2020161452A1 (en) * | 2019-02-06 | 2020-08-13 | Bb Brands Ltd | Cryotherapy device |
US10765880B2 (en) | 2012-07-05 | 2020-09-08 | Btl Medical Technologies S.R.O. | Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields |
US10765552B2 (en) | 2016-02-18 | 2020-09-08 | Zeltiq Aesthetics, Inc. | Cooling cup applicators with contoured heads and liner assemblies |
US10821295B1 (en) | 2015-07-01 | 2020-11-03 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10935174B2 (en) | 2014-08-19 | 2021-03-02 | Zeltiq Aesthetics, Inc. | Stress relief couplings for cryotherapy apparatuses |
US10952891B1 (en) | 2014-05-13 | 2021-03-23 | Zeltiq Aesthetics, Inc. | Treatment systems with adjustable gap applicators and methods for cooling tissue |
US11076879B2 (en) | 2017-04-26 | 2021-08-03 | Zeltiq Aesthetics, Inc. | Shallow surface cryotherapy applicators and related technology |
US11185690B2 (en) | 2016-05-23 | 2021-11-30 | BTL Healthcare Technologies, a.s. | Systems and methods for tissue treatment |
US11247039B2 (en) | 2016-05-03 | 2022-02-15 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US11247063B2 (en) | 2019-04-11 | 2022-02-15 | Btl Healthcare Technologies A.S. | Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy |
US11253717B2 (en) | 2015-10-29 | 2022-02-22 | Btl Healthcare Technologies A.S. | Aesthetic method of biological structure treatment by magnetic field |
US11253718B2 (en) | 2015-07-01 | 2022-02-22 | Btl Healthcare Technologies A.S. | High power time varying magnetic field therapy |
US11357697B2 (en) * | 2018-12-26 | 2022-06-14 | Therabody, Inc. | Percussive therapy device |
US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
US11395760B2 (en) | 2006-09-26 | 2022-07-26 | Zeltiq Aesthetics, Inc. | Tissue treatment methods |
US20220257460A1 (en) * | 2018-12-26 | 2022-08-18 | Therabody, Inc. | Percussive therapy device with interchangeable modules |
US11452670B2 (en) | 2018-12-26 | 2022-09-27 | Therabody, Inc. | Percussive therapy device with orientation, position, and force sensing and accessory therefor |
US11464993B2 (en) | 2016-05-03 | 2022-10-11 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
EP4082460A1 (en) * | 2021-04-28 | 2022-11-02 | High Technology Products, S.L.U. | Methods and systems for determining freezing of skin during cooling |
US11491342B2 (en) | 2015-07-01 | 2022-11-08 | Btl Medical Solutions A.S. | Magnetic stimulation methods and devices for therapeutic treatments |
US11534619B2 (en) | 2016-05-10 | 2022-12-27 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US11534335B2 (en) | 2014-10-01 | 2022-12-27 | Cryosa, Inc. | Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues |
US11564860B2 (en) | 2018-12-26 | 2023-01-31 | Therabody, Inc. | Percussive therapy device with electrically connected attachment |
US11806528B2 (en) | 2020-05-04 | 2023-11-07 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US11813221B2 (en) | 2019-05-07 | 2023-11-14 | Therabody, Inc. | Portable percussive massage device |
US11826565B2 (en) | 2020-05-04 | 2023-11-28 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US11857481B2 (en) | 2022-02-28 | 2024-01-02 | Therabody, Inc. | System for electrical connection of massage attachment to percussive therapy device |
US11896816B2 (en) | 2021-11-03 | 2024-02-13 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US11957635B2 (en) | 2015-06-20 | 2024-04-16 | Therabody, Inc. | Percussive therapy device with variable amplitude |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2559809T3 (en) | 2009-09-18 | 2016-02-16 | Viveve Inc. | Vaginal Remodeling Device |
WO2012135786A2 (en) * | 2011-04-01 | 2012-10-04 | The Regents Of The University Of California | Cryoelectric systems and methods for treatment of biological matter |
WO2013074664A1 (en) * | 2011-11-14 | 2013-05-23 | Kornstein Andrew | Cryolipolyis device having a curved applicator surface |
IT201600080827A1 (en) | 2016-08-01 | 2018-02-01 | Mcc Sistemi S R L | Apparatus and method for the therapeutic treatment of tissue lesions. |
WO2018060533A1 (en) * | 2016-09-28 | 2018-04-05 | High Technology Products, S.L. | Device for protecting skin and tissues for aesthetic cold treatments |
EP3522807A1 (en) | 2016-10-04 | 2019-08-14 | Avent, Inc. | Cooled rf probes |
CA3042402A1 (en) | 2016-11-02 | 2018-05-11 | Christopher J. P. Velis | Devices and methods for slurry generation |
US11324673B2 (en) | 2016-11-18 | 2022-05-10 | Miraki Innovation Think Tank Llc | Cosmetic appearance of skin |
US20200222103A1 (en) * | 2017-01-19 | 2020-07-16 | The General Hospital Corporation | Systems and methods for thermal treatment of tissue |
US20180263677A1 (en) * | 2017-03-16 | 2018-09-20 | Zeltiq Aesthetics, Inc. | Adhesive liners for cryotherapy |
CN110868968A (en) | 2017-04-05 | 2020-03-06 | 米拉基创新智库有限责任公司 | Delivery point-cooled slurry generation |
JP7085762B2 (en) | 2017-04-05 | 2022-06-17 | ミラキ イノベーション シンク タンク エルエルシー | Cold slurry confinement |
WO2018221848A1 (en) * | 2017-05-30 | 2018-12-06 | 주식회사 리센스메디컬 | Medical cooling device |
WO2019006027A1 (en) | 2017-06-30 | 2019-01-03 | R2 Dermatology, Inc. | Dermatological cryospray devices having linear array of nozzles and methods of use |
US10500342B2 (en) | 2017-08-21 | 2019-12-10 | Miraki Innovation Think Tank Llc | Cold slurry syringe |
KR102040913B1 (en) * | 2017-09-12 | 2019-11-05 | (주)클래시스 | Anti-freezing membrane for operating coolsculpting cryolipolysis |
US11400308B2 (en) | 2017-11-21 | 2022-08-02 | Cutera, Inc. | Dermatological picosecond laser treatment systems and methods using optical parametric oscillator |
RU2686107C1 (en) * | 2018-01-16 | 2019-04-24 | Федеральное государственное бюджетное учреждение науки "Кировский научно-исследовательский институт гематологии и переливания крови Федерального медико-биологического агентства" | Method of optimal cryoprotector selection having glycogen content in preserved blood leukocytes |
CN111902108A (en) * | 2018-02-26 | 2020-11-06 | 高技术产品有限公司 | Skin and tissue protection device for cold cosmetic care |
EP3773297A4 (en) * | 2018-04-29 | 2022-01-05 | Gandel, Brian A. | Device and method for inducing lypolysis in humans |
AU2019204574A1 (en) | 2018-06-27 | 2020-01-23 | Viveve, Inc. | Methods for treating urinary stress incontinence |
US20220176167A1 (en) * | 2018-08-02 | 2022-06-09 | Sofwave Medical Ltd. | Fat tissue treatment |
US20200069458A1 (en) * | 2018-08-31 | 2020-03-05 | Zeltiq Aesthetics, Inc. | Compositions, treatment systems, and methods for fractionally freezing tissue |
FI128964B (en) * | 2018-09-18 | 2021-04-15 | Cryotech Nordic As | Applicator device and related apparatus |
US10610280B1 (en) | 2019-02-02 | 2020-04-07 | Ayad K. M. Agha | Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat |
CN110078945B (en) * | 2019-05-28 | 2021-07-30 | 陕西科技大学 | Preparation method of gelatin-based high-strength hydrogel |
US11253720B2 (en) | 2020-02-29 | 2022-02-22 | Cutera, Inc. | Dermatological systems and methods with handpiece for coaxial pulse delivery and temperature sensing |
US10864380B1 (en) | 2020-02-29 | 2020-12-15 | Cutera, Inc. | Systems and methods for controlling therapeutic laser pulse duration |
CN113827545A (en) * | 2020-06-23 | 2021-12-24 | 微创医美科技(嘉兴)有限公司 | Antifreeze injection preparation assisting in frozen fat dissolution, liquid guide device, kit and frozen fat dissolution system |
CN114052887A (en) * | 2020-07-30 | 2022-02-18 | 上海微创惟美医疗科技(集团)有限公司 | Frozen fat-dissolving treatment component, device and antifreezing agent |
US20220087250A1 (en) * | 2020-09-24 | 2022-03-24 | Everest Medical Innovation GmbH | Cryoprotective Compositions and Methods for Protection of a Surgical Site During Cryosurgery |
TWI764421B (en) * | 2020-12-09 | 2022-05-11 | 羅莎國際有限公司 | Polymeric low temperature ionic gas promotes wound healing device |
CN112220551B (en) * | 2020-12-10 | 2021-04-16 | 微创医美科技(嘉兴)有限公司 | Freezing fat-dissolving treatment assembly and device |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070255362A1 (en) * | 2006-04-28 | 2007-11-01 | Juniper Medical, Inc. | Cryoprotectant for use with a cooling device for improved cooling of subcutaneous lipid-rich cells |
US20140303697A1 (en) * | 2011-11-16 | 2014-10-09 | The General Hospital Corporation | Method and apparatus for cryogenic treatment of skin tissue |
US20150223975A1 (en) * | 2014-02-12 | 2015-08-13 | The General Hospital Corporation | Method and apparatus for affecting pigmentation of tissue |
US20160135985A1 (en) * | 2008-08-07 | 2016-05-19 | The General Hospital Corporation | Method and apparatus for dermatological hypopigmentation |
Family Cites Families (763)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US681806A (en) | 1901-05-25 | 1901-09-03 | Armand Mignault | Lung-protector. |
US889810A (en) | 1908-01-04 | 1908-06-02 | Henry Robinson | Medicating and massaging appliance. |
US1093868A (en) | 1912-03-11 | 1914-04-21 | Henry W Jacobs | Means for forming couplings or joints. |
DE532976C (en) | 1930-07-29 | 1931-09-11 | Lorenz Akt Ges C | Transmitter device for spring writers, in which the transmission rails are moved in the direction of movement of the transmission buttons |
GB387960A (en) | 1932-09-17 | 1933-02-16 | William Hipon Horsfield | Electro-therapeutic massaging appliance |
FR854937A (en) | 1939-05-19 | 1940-04-27 | Suction massage device | |
GB578157A (en) | 1942-12-21 | 1946-06-18 | Johnson & Johnson | Improvements in and relating to surgical dressings |
US2516491A (en) | 1945-10-08 | 1950-07-25 | Henry A Swastek | Massage and shampoo device |
US2521780A (en) | 1947-06-12 | 1950-09-12 | Bertha A Dodd | Cushion or receptacle |
US2726658A (en) | 1953-04-27 | 1955-12-13 | Donald E Chessey | Therapeutic cooling devices for domestic and hospital use |
NL177982B (en) | 1953-04-29 | Siemens Ag | INFUSION DEVICE. | |
US2766619A (en) | 1953-06-26 | 1956-10-16 | Tribus Myron | Ice detecting apparatus |
CH333982A (en) | 1954-06-11 | 1958-11-15 | Usag Ultraschall Ag | Ultrasonic irradiation device |
US3093135A (en) | 1962-01-29 | 1963-06-11 | Max L Hirschhorn | Cooled surgical instrument |
US3133539A (en) | 1962-08-06 | 1964-05-19 | Eidus William | Thermoelectric medical instrument |
US3132688A (en) | 1963-04-08 | 1964-05-12 | Welville B Nowak | Electronic cold and/or hot compress device |
US3282267A (en) | 1964-05-05 | 1966-11-01 | Eidus William | Thermoelectric hypothermia instrument |
US3502080A (en) | 1965-06-28 | 1970-03-24 | Max L Hirschhorn | Thermoelectrically cooled surgical instrument |
US3341230A (en) | 1965-10-23 | 1967-09-12 | Swivelier Company Inc | Swivel unit |
US3591645A (en) | 1968-05-20 | 1971-07-06 | Gulf Research Development Co | Process for preparing a halogenated aromatic |
US3566871A (en) | 1968-06-11 | 1971-03-02 | American Cyanamid Co | Hydrophilic medical sponge and method of using same |
FR1595285A (en) | 1968-12-18 | 1970-06-08 | ||
US3703897A (en) | 1969-10-09 | 1972-11-28 | Kendall & Co | Hydrophobic non-adherent wound dressing |
US3587577A (en) | 1970-05-09 | 1971-06-28 | Oleg Alexandrovich Smirnov | Device for applying selective and general hypothermy to and reheating of human body through the common integuments thereof |
US3710784A (en) | 1972-04-03 | 1973-01-16 | C Taylor | Massaging device |
US4002221A (en) | 1972-09-19 | 1977-01-11 | Gilbert Buchalter | Method of transmitting ultrasonic impulses to surface using transducer coupling agent |
US3827436A (en) | 1972-11-10 | 1974-08-06 | Frigitronics Of Conn Inc | Multipurpose cryosurgical probe |
US3786814A (en) | 1972-12-15 | 1974-01-22 | T Armao | Method of preventing cryoadhesion of cryosurgical instruments and cryosurgical instruments |
US3942519A (en) | 1972-12-26 | 1976-03-09 | Ultrasonic Systems, Inc. | Method of ultrasonic cryogenic cataract removal |
DE2343910C3 (en) | 1973-08-31 | 1979-02-15 | Draegerwerk Ag, 2400 Luebeck | Cryomedical facility |
US4269068A (en) | 1974-02-21 | 1981-05-26 | Rockwell International Corporation | Ultrasonic couplant compositions and method for employing same |
SU532976A1 (en) | 1974-05-05 | 1978-11-05 | Киевский Государственный Институт Усовершенстовования Врачей Министерства Здравоохранения Ссср | Apparatus for local refrigeration of tissue |
US3993053A (en) | 1974-08-05 | 1976-11-23 | Murray Grossan | Pulsating massage system |
US3986385A (en) | 1974-08-05 | 1976-10-19 | Rosemount Engineering Company Limited | Apparatus for determining the freezing point of a liquid |
JPS5417360B2 (en) | 1974-08-15 | 1979-06-29 | ||
US4008910A (en) | 1975-05-16 | 1977-02-22 | Roche Thomas F | Universal electrical swivel |
US4026299A (en) | 1975-09-26 | 1977-05-31 | Vari-Temp Manufacturing Co. | Cooling and heating apparatus |
US4202336A (en) | 1976-05-14 | 1980-05-13 | Erbe Elektromedizin Kg | Cauterizing probes for cryosurgery |
US4140130A (en) | 1977-05-31 | 1979-02-20 | Storm Iii Frederick K | Electrode structure for radio frequency localized heating of tumor bearing tissue |
US4149529A (en) | 1977-09-16 | 1979-04-17 | Jobst Institute, Inc. | Portable thermo-hydraulic physiotherapy device |
USD260173S (en) | 1978-10-13 | 1981-08-11 | International Business Machines Corporation | Electrocardiograph |
US4178429A (en) | 1978-11-17 | 1979-12-11 | Scheffer Karl D | Catalyst for curing resins |
DE2851602A1 (en) | 1978-11-29 | 1980-06-12 | Messerschmitt Boelkow Blohm | Medical cooling device for localised inflammation - with Peltier element between heat conductive block and cooling pad applied to patient's skin |
US4381009A (en) | 1980-01-28 | 1983-04-26 | Bon F Del | Hand-held device for the local heat-treatment of the skin |
US4428368A (en) | 1980-09-29 | 1984-01-31 | Masakatsu Torii | Massage device |
US4470263A (en) | 1980-10-14 | 1984-09-11 | Kurt Lehovec | Peltier-cooled garment |
US4396011A (en) | 1981-01-09 | 1983-08-02 | Clairol Incorporated | Heating pad |
US4459854A (en) | 1981-07-24 | 1984-07-17 | National Research Development Corporation | Ultrasonic transducer coupling member |
US4528979A (en) | 1982-03-18 | 1985-07-16 | Kievsky Nauchno-Issledovatelsky Institut Otolaringologii Imeni Professora A.S. Kolomiiobenka | Cryo-ultrasonic surgical instrument |
JPS58187454A (en) | 1982-04-27 | 1983-11-01 | Nippon Kayaku Co Ltd | Anthraquinone compound |
US4555313A (en) | 1982-10-21 | 1985-11-26 | The United States Of America As Represented By The United States Department Of Energy | Method of forming a continuous polymeric skin on a cellular foam material |
US4548212A (en) | 1982-10-29 | 1985-10-22 | Leung Frank K | Apparatus for thermographic examinations |
US4483341A (en) | 1982-12-09 | 1984-11-20 | Atlantic Richfield Company | Therapeutic hypothermia instrument |
US4531524A (en) | 1982-12-27 | 1985-07-30 | Rdm International, Inc. | Circuit apparatus and method for electrothermal treatment of cancer eye |
US4644955A (en) | 1982-12-27 | 1987-02-24 | Rdm International, Inc. | Circuit apparatus and method for electrothermal treatment of cancer eye |
US4961422A (en) | 1983-01-21 | 1990-10-09 | Marchosky J Alexander | Method and apparatus for volumetric interstitial conductive hyperthermia |
DE3308553C2 (en) | 1983-03-10 | 1986-04-10 | Udo Prof. Dr.med. 4130 Moers Smidt | Means for reducing the human body weight |
US4614191A (en) | 1983-09-02 | 1986-09-30 | Perler Robert F | Skin-cooling probe |
AU558943B2 (en) | 1983-10-26 | 1987-02-12 | Nihondenjihachiryokikenkyusho Co. Ltd. | Magnetic field generating therapeutic appliance |
JPS6094113A (en) | 1983-10-26 | 1985-05-27 | Kobe Steel Ltd | Mobile dust collector |
JPS6094113U (en) | 1983-12-06 | 1985-06-27 | 瀧川株式会社 | beauty facial machine |
US5158070A (en) | 1983-12-14 | 1992-10-27 | Edap International, S.A. | Method for the localized destruction of soft structures using negative pressure elastic waves |
JPS60502042A (en) | 1984-01-18 | 1985-11-28 | ベイリ−,デ−ビッド・フランクリン | Multilayer disposable medical temperature blanket |
US4603076A (en) | 1985-03-04 | 1986-07-29 | Norwood Industries, Inc. | Hydrophilic foam |
US4869250A (en) | 1985-03-07 | 1989-09-26 | Thermacor Technology, Inc. | Localized cooling apparatus |
US4664110A (en) | 1985-03-18 | 1987-05-12 | University Of Southern California | Controlled rate freezing for cryorefractive surgery |
US4585002A (en) | 1985-04-22 | 1986-04-29 | Igor Kissin | Method and apparatus for treatment of pain by frequently alternating temperature stimulation |
JPS6282977A (en) | 1985-10-07 | 1987-04-16 | オムロン株式会社 | Heating/cooling low frequency medical treatment apparatus |
US4700701A (en) | 1985-10-23 | 1987-10-20 | Montaldi David H | Sterilization method and apparatus |
JPH0765230B2 (en) | 1986-09-19 | 1995-07-12 | 三菱マテリアル株式会社 | Method for forming porous layer on metal surface |
GB2190842B (en) | 1986-05-05 | 1990-03-07 | Oreal | Apparatus for the cryogenic treatment of the skin |
AU7039687A (en) | 1986-05-16 | 1987-12-01 | Termac S.A. | Therapeutic device including a mass of a thermally active material |
SU1563684A1 (en) | 1986-05-26 | 1990-05-15 | Томский государственный медицинский институт | Cryosurgical scalpel |
GB8620227D0 (en) | 1986-08-20 | 1986-10-01 | Smith & Nephew Ass | Wound dressing |
US4880564A (en) | 1986-09-29 | 1989-11-14 | Ciba-Geigy Corporation | Antifoams for aqueous systems and their use |
US4741338A (en) | 1986-10-06 | 1988-05-03 | Toshiaki Miyamae | Thermoelectric physical remedy apparatus |
US5018521A (en) | 1986-10-24 | 1991-05-28 | Campbell William P | Method of and apparatus for increased transfer of heat into or out of the body |
US4764463A (en) | 1986-10-30 | 1988-08-16 | The University Of Tennessee Research Corporation | Platelet cyropreservation |
US4906463A (en) | 1986-12-22 | 1990-03-06 | Cygnus Research Corporation | Transdermal drug-delivery composition |
CN86200604U (en) | 1987-01-10 | 1987-10-14 | Zhichang Yang | Apparatus for freezing freckle and treating some skin diseases with freezing |
US4846176A (en) | 1987-02-24 | 1989-07-11 | Golden Theodore A | Thermal bandage |
US4962761A (en) | 1987-02-24 | 1990-10-16 | Golden Theodore A | Thermal bandage |
GB8706141D0 (en) | 1987-03-16 | 1987-04-23 | Thorner D | Treatment of damaged limb |
US4935345A (en) | 1987-04-07 | 1990-06-19 | Arizona Board Of Regents | Implantable microelectronic biochemical sensor incorporating thin film thermopile |
US4802475A (en) | 1987-06-22 | 1989-02-07 | Weshahy Ahmed H A G | Methods and apparatus of applying intra-lesional cryotherapy |
US5084671A (en) | 1987-09-02 | 1992-01-28 | Tokyo Electron Limited | Electric probing-test machine having a cooling system |
US5143063A (en) | 1988-02-09 | 1992-09-01 | Fellner Donald G | Method of removing adipose tissue from the body |
JPH01223961A (en) | 1988-03-02 | 1989-09-07 | Kineshio:Kk | Method for improvement of muscle subcutaneous tissue and subcutaneous tissue activating device |
US5065752A (en) | 1988-03-29 | 1991-11-19 | Ferris Mfg. Co. | Hydrophilic foam compositions |
DK161260C (en) | 1988-05-06 | 1991-12-30 | Paul Verner Nielsen | flow measurement |
US4930317A (en) | 1988-05-20 | 1990-06-05 | Temperature Research Corporation | Apparatus for localized heat and cold therapy |
DE3821219C1 (en) | 1988-06-23 | 1989-08-24 | Phywe Systeme Gmbh, 3400 Goettingen, De | |
US5108390A (en) | 1988-11-14 | 1992-04-28 | Frigitronics, Inc. | Flexible cryoprobe |
US4905697A (en) | 1989-02-14 | 1990-03-06 | Cook Pacemaker Corporation | Temperature-controlled cardiac pacemaker responsive to body motion |
US5024650A (en) | 1989-02-15 | 1991-06-18 | Matsushita Electric Works, Ltd. | Stress dissolving refreshment system |
DE8905769U1 (en) | 1989-05-09 | 1989-07-13 | Schulte, Franz-Josef, Dipl.-Ing., 5787 Olsberg, De | |
US5200170A (en) | 1989-07-18 | 1993-04-06 | Mcdow Ronald A | Medical process--use of dichlorodifluoromethane (CCl2 F2) and chlorodifluoromethane (CHClF2) as cryogens for treating skin lesions |
US5516505A (en) | 1989-07-18 | 1996-05-14 | Mcdow; Ronald A. | Method for using cryogenic agents for treating skin lesions |
JP2625548B2 (en) | 1989-07-19 | 1997-07-02 | 沖電気工業株式会社 | Image generation method and image generation device |
US5160312A (en) | 1990-02-09 | 1992-11-03 | W. R. Grace & Co.-Conn. | Cryopreservation process for direct transfer of embryos |
US5575812A (en) | 1990-02-26 | 1996-11-19 | Vesture Corporation | Cooling pad method |
US5817149A (en) | 1990-02-26 | 1998-10-06 | Vesture Corporation | Heat application method |
US5339541A (en) | 1990-02-26 | 1994-08-23 | Vesture Corporation | Footwear with therapeutic pad |
JPH03259975A (en) | 1990-03-09 | 1991-11-20 | Matsushita Refrig Co Ltd | Water-repellent coating composition and heat exchanger coated therewith |
FR2659851A1 (en) | 1990-03-20 | 1991-09-27 | Karagozian Serge | MASSAGE APPARATUS. |
JP3065657B2 (en) | 1990-06-08 | 2000-07-17 | 株式会社リコー | Dry type electrophotographic toner |
US5362966A (en) | 1990-06-27 | 1994-11-08 | Rosenthal Robert D | Measurement of finger temperature in near-infrared quantitative measurement instrument |
US5148804A (en) | 1990-06-28 | 1992-09-22 | Hill Dennis M | Device, system, and methods for applying cryotherapy |
JPH0493597A (en) | 1990-08-08 | 1992-03-26 | Matsushita Refrig Co Ltd | Water repellent coating composition and heat exchanger coated with water repellant coating composition |
US5336616A (en) | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
GB2248183A (en) | 1990-09-25 | 1992-04-01 | Lin Ju Nin | Facial sauna apparatus |
US5209227A (en) | 1990-09-25 | 1993-05-11 | Richard Deutsch | Thermoelectric therapy device and moisturizing device therefor |
US5221726A (en) | 1990-10-09 | 1993-06-22 | Mcneil-Ppc, Inc. | Hydrophilic materials useful in preparing fluid-absorbent products |
US5342617A (en) | 1990-12-03 | 1994-08-30 | Medical Polymers, Inc. | Water-based human tissue lubricant |
US5139496A (en) * | 1990-12-20 | 1992-08-18 | Hed Aharon Z | Ultrasonic freeze ablation catheters and probes |
JP3217386B2 (en) | 1991-04-24 | 2001-10-09 | オリンパス光学工業株式会社 | Diagnostic system |
US5358467A (en) | 1991-05-05 | 1994-10-25 | Anatole Milstein | Method for vacuum mechanothermal stimulation of the body surface |
US5207674A (en) | 1991-05-13 | 1993-05-04 | Hamilton Archie C | Electronic cryogenic surgical probe apparatus and method |
WO1993000807A1 (en) | 1991-07-03 | 1993-01-21 | Cryolife, Inc. | Method for stabilization of biomaterials |
US20010031459A1 (en) | 1991-07-08 | 2001-10-18 | The American National Red Cross | Method of preparing tissues for vitrification |
DE4125463A1 (en) | 1991-08-01 | 1993-02-04 | Deutsches Inst Lebensmitteltec | METHOD AND DEVICE FOR CONTINUOUS, CONTROLLED STRUCTURING, IN PARTICULAR CRYSTALLIZATION OF SUBSTANCE SYSTEMS IN A FLOWABLE CONDITION, PARTICULARLY FATTY MEASURES, LIKE CHOCOLATE MATERIAL |
US5352711A (en) | 1991-08-12 | 1994-10-04 | The Proctor & Gamble Company | Method for hydrophilizing absorbent foam materials |
US5169384A (en) | 1991-08-16 | 1992-12-08 | Bosniak Stephen L | Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue |
US5514105A (en) | 1992-01-03 | 1996-05-07 | The Procter & Gamble Company | Resilient plastic web exhibiting reduced skin contact area and enhanced fluid transfer properties |
US5531742A (en) | 1992-01-15 | 1996-07-02 | Barken; Israel | Apparatus and method for computer controlled cryosurgery |
GB9201940D0 (en) | 1992-01-28 | 1992-03-18 | S I Ind Limited | Cooling or heating arrangement |
IT1259424B (en) | 1992-03-11 | 1996-03-18 | CONTAINMENT AND COOLING ELEMENT TO APPLY TO ARTS AFFECTED BY TRAUMAS | |
WO1993019705A1 (en) | 1992-03-31 | 1993-10-14 | Massachusetts Institute Of Technology | Apparatus and method for acoustic heat generation and hyperthermia |
US5954680A (en) | 1992-06-19 | 1999-09-21 | Augustine Medical, Inc. | Near hyperthermic heater wound covering |
DE4224595A1 (en) | 1992-07-23 | 1994-01-27 | Steindorf Susanne Ruth | Surgical instrument for treating diseased tissue esp. prostate - has heating system located in probe within body opening and-or diseased organs adjacent to body openings |
AU5008293A (en) | 1992-08-17 | 1994-03-15 | Thomas L. Mehl | Hand-held, multi-purpose portable steamer |
US5327886A (en) | 1992-08-18 | 1994-07-12 | Chiu Cheng Pang | Electronic massage device with cold/hot compress function |
AU692424B2 (en) | 1992-10-02 | 1998-06-11 | Beiersdorf Aktiengesellschaft | Hydrophilic polyurethane gel foams, particularly for treating deep wounds, wound dressing based on hydrophilic polyurethane gel foams and method of manufacture |
GB9222335D0 (en) | 1992-10-23 | 1992-12-09 | Unilever Plc | Acyl lactylates as skin elasticity enhancing agents |
US5314423A (en) | 1992-11-03 | 1994-05-24 | Seney John S | Cold electrode pain alleviating tissue treatment assembly |
DE4238291A1 (en) | 1992-11-13 | 1994-05-19 | Diehl Gmbh & Co | Cryo-therapy system for small areal freezing of surfaces esp. for skin alterations - has cold probe and heat exchanger which are connected heat-conducting with each other by Peltier elements having heat contact surfaces |
US5333460A (en) | 1992-12-21 | 1994-08-02 | Carrier Corporation | Compact and serviceable packaging of a self-contained cryocooler system |
US5277030A (en) | 1993-01-22 | 1994-01-11 | Welch Allyn, Inc. | Preconditioning stand for cooling probe |
US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
US6620188B1 (en) | 1998-08-24 | 2003-09-16 | Radiant Medical, Inc. | Methods and apparatus for regional and whole body temperature modification |
US5902256A (en) | 1993-02-12 | 1999-05-11 | Jb Research, Inc. | Massage unit with replaceable hot and cold packs |
US5433717A (en) | 1993-03-23 | 1995-07-18 | The Regents Of The University Of California | Magnetic resonance imaging assisted cryosurgery |
US5456703A (en) | 1993-04-28 | 1995-10-10 | Therabite Corporation | Apparatus for application of heat/cold to target regions of the human anatomy |
WO1994026216A1 (en) | 1993-05-12 | 1994-11-24 | Yablon Jeffrey S | Portable therapeutic device |
RU2047298C1 (en) | 1993-05-27 | 1995-11-10 | Специализированное конструкторско-технологическое бюро "Норд" | Device for cryomassage |
JP3715312B2 (en) | 1993-06-04 | 2005-11-09 | バイオタイム インク | Plasma-like solution |
US5411541A (en) | 1993-08-05 | 1995-05-02 | Oansh Designs Ltd. | Portable fluid therapy device |
US5372608A (en) | 1993-08-12 | 1994-12-13 | Johnson; Bertrand L. | Circulating chilled-fluid therapeutic device |
US5334131A (en) | 1993-08-20 | 1994-08-02 | Omandam Ismael C | Strap-on massager with vibratory unbalanced weight |
US5891617A (en) | 1993-09-15 | 1999-04-06 | Organogenesis Inc. | Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing |
US5871526A (en) | 1993-10-13 | 1999-02-16 | Gibbs; Roselle | Portable temperature control system |
US5764794A (en) | 1993-10-27 | 1998-06-09 | Perlin; Kenneth | Method and apparatus for electronically storing alphanumeric characters |
GB2283678B (en) | 1993-11-09 | 1998-06-03 | Spembly Medical Ltd | Cryosurgical catheter probe |
US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
JPH07194666A (en) | 1993-12-30 | 1995-08-01 | Daisee Kogyo Kk | Massaging appliance and method |
US5472416A (en) | 1994-01-10 | 1995-12-05 | Very Inventive Physicians, Inc. | Tumescent lipoplastic method and apparatus |
RU2036667C1 (en) | 1994-01-24 | 1995-06-09 | Олег Алексеевич Машков | Method for treating disseminated psoriasis |
US5497596A (en) | 1994-01-27 | 1996-03-12 | E. I. Du Pont De Nemours And Company | Method for reducing penetration of liquid through nonwoven film-fibril sheets pierced by fastening elements |
GB2286660A (en) | 1994-02-01 | 1995-08-23 | David Thorner | Peltier effect cooling apparatus for treating diseased or injured tissue |
US5647868A (en) | 1994-02-02 | 1997-07-15 | Chinn; Douglas Owen | Cryosurgical integrated control and monitoring system and method |
US5725483A (en) | 1994-02-22 | 1998-03-10 | Podolsky; Grigory | Massaging device |
US5363347A (en) | 1994-02-24 | 1994-11-08 | Hap Nguyen | Vending tanning timer |
US5833685A (en) | 1994-03-15 | 1998-11-10 | Tortal; Proserfina R. | Cryosurgical technique and devices |
US5507790A (en) | 1994-03-21 | 1996-04-16 | Weiss; William V. | Method of non-invasive reduction of human site-specific subcutaneous fat tissue deposits by accelerated lipolysis metabolism |
US5505726A (en) | 1994-03-21 | 1996-04-09 | Dusa Pharmaceuticals, Inc. | Article of manufacture for the photodynamic therapy of dermal lesion |
JPH07268274A (en) | 1994-04-01 | 1995-10-17 | Kansai Paint Co Ltd | Composition and method for imparting hydrophilicity |
JP3263275B2 (en) | 1994-04-05 | 2002-03-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Apparatus for laser treatment of living tissue and laser treatment apparatus for flame-like nevus |
US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
US6230501B1 (en) | 1994-04-14 | 2001-05-15 | Promxd Technology, Inc. | Ergonomic systems and methods providing intelligent adaptive surfaces and temperature control |
US5792080A (en) | 1994-05-18 | 1998-08-11 | Matsushita Electric Works, Ltd. | Massaging apparatus having self-adjusting constant strength and non-adjust strength modes |
US5672172A (en) | 1994-06-23 | 1997-09-30 | Vros Corporation | Surgical instrument with ultrasound pulse generator |
US5505730A (en) | 1994-06-24 | 1996-04-09 | Stuart D. Edwards | Thin layer ablation apparatus |
IL110176A (en) | 1994-06-30 | 1999-12-31 | Israel State | Multiprobe surgical cryogenic apparatus |
US5967976A (en) | 1994-08-19 | 1999-10-19 | Novoste Corporation | Apparatus and methods for procedures related to the electrophysiology of the heart |
US5529067A (en) | 1994-08-19 | 1996-06-25 | Novoste Corporation | Methods for procedures related to the electrophysiology of the heart |
US5514170A (en) | 1994-08-25 | 1996-05-07 | Mauch; Rose M. | Cold pack device |
USD362091S (en) | 1994-09-09 | 1995-09-05 | Emerson Electric Co. | Combined wet/dry vacuum cleaner with detachable blower |
US5486207A (en) | 1994-09-20 | 1996-01-23 | Mahawili; Imad | Thermal pad for portable body heating/cooling system and method of use |
US5895418A (en) | 1994-09-30 | 1999-04-20 | Saringer Research Inc. | Device for producing cold therapy |
US5628769A (en) | 1994-09-30 | 1997-05-13 | Saringer Research, Inc. | Method and devices for producing somatosensory stimulation using temperature |
AU4106796A (en) | 1994-11-09 | 1996-06-06 | Federico Castro Munozledo | Wound repair dressings and methods for their preservation |
US5817145A (en) | 1994-11-21 | 1998-10-06 | Augustine Medical, Inc. | Wound treatment device |
DE4445627A1 (en) | 1994-12-21 | 1996-06-27 | Holland Letz Horst | Heat exchanger for thermal therapy pad |
US6426445B1 (en) | 1995-01-10 | 2002-07-30 | The Procter & Gamble Company | Absorbent members comprising an agglomerate of hydrogel-forming absorbent polymer and particulate hydrophilic foam |
US5735844A (en) | 1995-02-01 | 1998-04-07 | The General Hospital Corporation | Hair removal using optical pulses |
US5647051A (en) | 1995-02-22 | 1997-07-08 | Seabrook Medical Systems, Inc. | Cold therapy system with intermittent fluid pumping for temperature control |
US5635162A (en) | 1995-02-23 | 1997-06-03 | Ultradent Products, Inc. | Hemostatic composition for treating gingival area |
US5980561A (en) | 1995-03-01 | 1999-11-09 | Kolen; Paul T. | Applying thermal therapy to living tissue |
IES66404B2 (en) | 1995-03-01 | 1995-12-27 | Shannon Cool Limited | Cold therapy apparatus |
US5558376A (en) | 1995-03-02 | 1996-09-24 | Engineered Transitions Co., Inc. | Low profile swivel adapters |
US5580714A (en) | 1995-03-08 | 1996-12-03 | Celox Laboratories, Inc. | Cryopreservation solution |
EP0833590B1 (en) | 1995-04-28 | 2003-10-01 | Endocare, Inc. | Cryosurgical integrated control monitoring system |
US5755753A (en) | 1995-05-05 | 1998-05-26 | Thermage, Inc. | Method for controlled contraction of collagen tissue |
US6430446B1 (en) | 1995-05-05 | 2002-08-06 | Thermage, Inc. | Apparatus for tissue remodeling |
US5660836A (en) | 1995-05-05 | 1997-08-26 | Knowlton; Edward W. | Method and apparatus for controlled contraction of collagen tissue |
US6241753B1 (en) | 1995-05-05 | 2001-06-05 | Thermage, Inc. | Method for scar collagen formation and contraction |
US6425912B1 (en) | 1995-05-05 | 2002-07-30 | Thermage, Inc. | Method and apparatus for modifying skin surface and soft tissue structure |
US5634890A (en) | 1995-05-09 | 1997-06-03 | Aquasage, Inc. | Water massage therapy device and method for using the same |
US5901707A (en) | 1995-05-19 | 1999-05-11 | Hpl Biomedical, Inc. | Silicone mask for cryosurgery and method |
US5741248A (en) | 1995-06-07 | 1998-04-21 | Temple University-Of The Commonwealth System Of Higher Education | Fluorochemical liquid augmented cryosurgery |
US5769879A (en) | 1995-06-07 | 1998-06-23 | Medical Contouring Corporation | Microwave applicator and method of operation |
US5965438A (en) | 1995-06-07 | 1999-10-12 | Phyton, Inc. | Cryopreservation of plant cells |
DE69624668T2 (en) | 1995-07-25 | 2003-08-28 | Massachusetts Inst Technology | IMPROVED TRANSDERMAL TRANSPORTATION USING ULTRASOUND |
US5853364A (en) | 1995-08-07 | 1998-12-29 | Nellcor Puritan Bennett, Inc. | Method and apparatus for estimating physiological parameters using model-based adaptive filtering |
US5746736A (en) | 1995-08-09 | 1998-05-05 | Lumedics, Ltd. | Cryogenic laser lithotripsy with enhanced light absorption |
US5964749A (en) | 1995-09-15 | 1999-10-12 | Esc Medical Systems Ltd. | Method and apparatus for skin rejuvenation and wrinkle smoothing |
US5654546A (en) | 1995-11-07 | 1997-08-05 | Molecular Imaging Corporation | Variable temperature scanning probe microscope based on a peltier device |
US5733280A (en) | 1995-11-15 | 1998-03-31 | Avitall; Boaz | Cryogenic epicardial mapping and ablation |
US5634940A (en) | 1995-12-13 | 1997-06-03 | Panyard; Albert A. | Therapeutic structure and methods |
US5755755A (en) | 1995-12-13 | 1998-05-26 | Panyard; Albert A. | Therapeutic structure and method |
JPH09164163A (en) | 1995-12-15 | 1997-06-24 | Matsushita Electric Ind Co Ltd | Local part cooler-heater |
WO1997022262A2 (en) | 1995-12-19 | 1997-06-26 | Jie Hao | Soft ice |
AU1349697A (en) | 1995-12-29 | 1997-07-28 | Life Resuscitation Technologies, Inc. | Total body cooling system |
US7229436B2 (en) | 1996-01-05 | 2007-06-12 | Thermage, Inc. | Method and kit for treatment of tissue |
US7267675B2 (en) | 1996-01-05 | 2007-09-11 | Thermage, Inc. | RF device with thermo-electric cooler |
US7473251B2 (en) | 1996-01-05 | 2009-01-06 | Thermage, Inc. | Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient |
US7189230B2 (en) | 1996-01-05 | 2007-03-13 | Thermage, Inc. | Method for treating skin and underlying tissue |
US7115123B2 (en) | 1996-01-05 | 2006-10-03 | Thermage, Inc. | Handpiece with electrode and non-volatile memory |
US7022121B2 (en) | 1999-03-09 | 2006-04-04 | Thermage, Inc. | Handpiece for treatment of tissue |
US7006874B2 (en) | 1996-01-05 | 2006-02-28 | Thermage, Inc. | Treatment apparatus with electromagnetic energy delivery device and non-volatile memory |
US7141049B2 (en) | 1999-03-09 | 2006-11-28 | Thermage, Inc. | Handpiece for treatment of tissue |
US6350276B1 (en) | 1996-01-05 | 2002-02-26 | Thermage, Inc. | Tissue remodeling apparatus containing cooling fluid |
JP2000503154A (en) | 1996-01-11 | 2000-03-14 | エムアールジェイ インコーポレイテッド | System for controlling access and distribution of digital ownership |
US5651773A (en) | 1996-01-19 | 1997-07-29 | Perry; Larry C. | Skin protector for ultrasonic-assisted liposuction and accessories |
US5650450A (en) | 1996-01-25 | 1997-07-22 | Foamex L.P. | Hydrophilic urethane foam |
FR2744358B1 (en) | 1996-02-01 | 1998-05-07 | Biogenie Beaute Concept | MASSAGE HEAD COMBINING SUCTION MASSAGE AND ELECTROTHERAPY |
FR2745935B1 (en) | 1996-03-11 | 1998-05-22 | Ygk Holding S A | AUTOMATED TANNING EQUIPMENT |
US5654279A (en) | 1996-03-29 | 1997-08-05 | The Regents Of The University Of California | Tissue destruction in cryosurgery by use of thermal hysteresis |
US6180867B1 (en) | 1996-04-17 | 2001-01-30 | General Electric Company | Thermal sensor array and methods of fabrication and use |
SE510531C2 (en) | 1996-05-02 | 1999-05-31 | Sca Hygiene Prod Ab | Hollow-casing layer for absorbing articles, as well as ways of making the casing layer |
US6230051B1 (en) | 1996-06-18 | 2001-05-08 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
AU3813897A (en) | 1996-07-25 | 1998-02-20 | Light Medicine, Inc. | Photodynamic therapy apparatus and methods |
US5976123A (en) | 1996-07-30 | 1999-11-02 | Laser Aesthetics, Inc. | Heart stabilization |
US5966763A (en) | 1996-08-02 | 1999-10-19 | Hill-Rom, Inc. | Surface pad system for a surgical table |
US6102885A (en) | 1996-08-08 | 2000-08-15 | Bass; Lawrence S. | Device for suction-assisted lipectomy and method of using same |
US5840080A (en) | 1996-08-15 | 1998-11-24 | Der Ovanesian; Mary | Hot or cold applicator with inner element |
US5665053A (en) | 1996-09-27 | 1997-09-09 | Jacobs; Robert A. | Apparatus for performing endermology with ultrasound |
US5941825A (en) | 1996-10-21 | 1999-08-24 | Philipp Lang | Measurement of body fat using ultrasound methods and devices |
BE1010730A7 (en) | 1996-11-04 | 1998-12-01 | Pira Luc Louis Marie Francis | Cryoprobe based on peltier module. |
US5952168A (en) * | 1996-11-07 | 1999-09-14 | 21St Century Medicine, Inc. | Method for vitrification of biological materials using alkoxylated compounds |
US5800490A (en) | 1996-11-07 | 1998-09-01 | Patz; Herbert Samuel | Lightweight portable cooling or heating device with multiple applications |
USD399493S (en) | 1996-11-11 | 1998-10-13 | Toshiba Kikai Kabushiki Kaisha | Machine tool operation console |
US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6273884B1 (en) | 1997-05-15 | 2001-08-14 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
US7204832B2 (en) | 1996-12-02 | 2007-04-17 | Pálomar Medical Technologies, Inc. | Cooling system for a photo cosmetic device |
US20060149343A1 (en) | 1996-12-02 | 2006-07-06 | Palomar Medical Technologies, Inc. | Cooling system for a photocosmetic device |
US5964092A (en) | 1996-12-13 | 1999-10-12 | Nippon Sigmax, Co., Ltd. | Electronic cooling apparatus |
DK1314400T3 (en) | 1996-12-31 | 2007-10-15 | Altea Therapeutics Corp | Microporation of tissues for delivery of bioactive agents |
US6102875A (en) | 1997-01-16 | 2000-08-15 | Jones; Rick E. | Apparatus for combined application of massage, accupressure and biomagnetic therapy |
US5830208A (en) | 1997-01-31 | 1998-11-03 | Laserlite, Llc | Peltier cooled apparatus and methods for dermatological treatment |
JPH10216169A (en) | 1997-02-05 | 1998-08-18 | Kanae Kagawa:Kk | Cold-feeling/cooling sheet |
JPH10223961A (en) | 1997-02-10 | 1998-08-21 | Furukawa Electric Co Ltd:The | Optical amplifier |
US5925026A (en) | 1997-03-10 | 1999-07-20 | Kimberly-Clark Worldwide, Inc. | Apertured absorbent pads for use in absorbent articles |
AU6865298A (en) | 1997-03-17 | 1998-10-12 | Boris Rubinsky | The use of cryoprotective agent compounds during cryosurgery |
WO1998041157A1 (en) | 1997-03-17 | 1998-09-24 | Boris Rubinsky | Freezing method for controlled removal of fatty tissue by liposuction |
GB2323659A (en) | 1997-03-25 | 1998-09-30 | Paul Weatherstone | Hand directable chilled air blower |
NL1007696C1 (en) | 1997-05-01 | 1998-11-03 | Inst Voor Agrotech Onderzoek | Controlled-release coated substance. |
US5817050A (en) | 1997-05-29 | 1998-10-06 | Klein; Jeffrey A. | Liposuction cannula |
AU8149198A (en) | 1997-06-17 | 1999-01-04 | Cool Laser Optics, Inc. | Method and apparatus for temperature control of biologic tissue with simultaneous irradiation |
US6104959A (en) | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
AU766783B2 (en) | 1997-08-19 | 2003-10-23 | Philipp Lang | Ultrasonic transmission films and devices, particularly for hygienic transducer surfaces |
FR2767476B1 (en) | 1997-08-25 | 1999-10-15 | Juliette Dubois | PHYSIOTHERAPEUTIC DEVICE FOR THE TREATMENT OF THE SKIN BY VACUUM AND ULTRASOUND SUCTION |
US6023932A (en) | 1997-08-25 | 2000-02-15 | Johnston; Robert | Topical cooling device |
US5802865A (en) | 1997-09-05 | 1998-09-08 | The Sharper Image | Evaporative personal cooler |
US6113558A (en) | 1997-09-29 | 2000-09-05 | Angiosonics Inc. | Pulsed mode lysis method |
US6623430B1 (en) | 1997-10-14 | 2003-09-23 | Guided Therapy Systems, Inc. | Method and apparatus for safety delivering medicants to a region of tissue using imaging, therapy and temperature monitoring ultrasonic system |
USD424699S (en) | 1997-10-23 | 2000-05-09 | Donald Allen | Wound dressing |
US6071239A (en) | 1997-10-27 | 2000-06-06 | Cribbs; Robert W. | Method and apparatus for lipolytic therapy using ultrasound energy |
GB9724186D0 (en) | 1997-11-14 | 1998-01-14 | British Tech Group | Low temperature coatings |
US6113559A (en) | 1997-12-29 | 2000-09-05 | Klopotek; Peter J. | Method and apparatus for therapeutic treatment of skin with ultrasound |
US6104952A (en) | 1998-01-07 | 2000-08-15 | Tu; Lily Chen | Devices for treating canker sores, tissues and methods thereof |
DE19800416C2 (en) | 1998-01-08 | 2002-09-19 | Storz Karl Gmbh & Co Kg | Device for the treatment of body tissue, in particular soft tissue close to the surface, by means of ultrasound |
US6251129B1 (en) | 1998-03-24 | 2001-06-26 | Innercool Therapies, Inc. | Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control |
US7458984B2 (en) | 1998-01-23 | 2008-12-02 | Innercool Therapies, Inc. | System and method for inducing hypothermia with active patient temperature control employing catheter-mounted temperature sensor and temperature projection algorithm |
IL126783A0 (en) | 1998-03-05 | 1999-08-17 | M T R E Advanced Technology Lt | System and method for heat control of a living body |
US6047215A (en) | 1998-03-06 | 2000-04-04 | Sonique Surgical Systems, Inc. | Method and apparatus for electromagnetically assisted liposuction |
AU3450799A (en) | 1998-03-12 | 1999-09-27 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation of the skin |
BR9909656A (en) | 1998-03-17 | 2001-10-16 | Gary S Kochamba | Method and apparatus for stabilizing tissue |
US6551349B2 (en) | 1998-03-24 | 2003-04-22 | Innercool Therapies, Inc. | Selective organ cooling apparatus |
ES2403359T3 (en) | 1998-03-27 | 2013-05-17 | The General Hospital Corporation | Procedure and apparatus for the selective determination of lipid rich tissues |
US6031525A (en) | 1998-04-01 | 2000-02-29 | New York University | Method and apparatus for writing |
FR2776920B3 (en) | 1998-04-03 | 2000-04-28 | Elie Piana | VACUUM MASSAGE DEVICE |
US6569189B1 (en) | 1998-04-06 | 2003-05-27 | Augustine Medical, Inc. | Tissue treatment apparatus including a bandpass filter transparent to selected wavelengths of IR electromagnetic spectrum |
US6264649B1 (en) | 1998-04-09 | 2001-07-24 | Ian Andrew Whitcroft | Laser treatment cooling head |
US5997530A (en) | 1998-04-13 | 1999-12-07 | The Regents Of The University Of California | Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations |
US6354297B1 (en) | 1998-04-16 | 2002-03-12 | The Uniformed Services University Of The Health Sciences | Method and device for destroying fat cells by induction of programmed cell death |
JP4191384B2 (en) | 1998-04-23 | 2008-12-03 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ テキサス システム | A heat transfer blanket and method for managing patient temperature. |
US6375673B1 (en) | 1998-04-23 | 2002-04-23 | The Board Of Regents Of The University Of Texas System | Heat transfer blanket for and method of controlling a patient's temperature |
US6113626A (en) | 1998-04-23 | 2000-09-05 | The Board Of Regents Of The University Of Texas System | Heat transfer blanket for controlling a patient's temperature |
US6151735A (en) | 1998-05-05 | 2000-11-28 | Imak Corporation | Zone inflatable orthopedic pillow |
US6015390A (en) | 1998-06-12 | 2000-01-18 | D. Krag Llc | System and method for stabilizing and removing tissue |
US6039694A (en) | 1998-06-25 | 2000-03-21 | Sonotech, Inc. | Coupling sheath for ultrasound transducers |
US6312453B1 (en) | 1998-07-16 | 2001-11-06 | Olympic Medical Corp. | Device for cooling infant's brain |
US6620189B1 (en) | 2000-02-28 | 2003-09-16 | Radiant Medical, Inc. | Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter |
US6673098B1 (en) | 1998-08-24 | 2004-01-06 | Radiant Medical, Inc. | Disposable cassette for intravascular heat exchange catheter |
US6139545A (en) | 1998-09-09 | 2000-10-31 | Vidaderm | Systems and methods for ablating discrete motor nerve regions |
US6093230A (en) | 1998-10-12 | 2000-07-25 | Allegiance Corporation | Filter assembly comprising two filter elements separated by a hydrophobic foam |
US6059820A (en) | 1998-10-16 | 2000-05-09 | Paradigm Medical Corporation | Tissue cooling rod for laser surgery |
TW514521B (en) | 1998-10-16 | 2002-12-21 | Coolsystems Inc | Compliant heat exchange splint and control unit |
US6150148A (en) | 1998-10-21 | 2000-11-21 | Genetronics, Inc. | Electroporation apparatus for control of temperature during the process |
IL126723A0 (en) | 1998-10-22 | 1999-08-17 | Medoc Ltd | Vaginal probe and method |
DE19852948C2 (en) | 1998-11-12 | 2002-07-18 | Asclepion Meditec Ag | Dermatological handpiece |
US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6120519A (en) | 1998-12-02 | 2000-09-19 | Weber; Paul J. | Advanced fulcrum liposuction device |
US7785359B2 (en) | 1998-12-18 | 2010-08-31 | Traumatec, Inc. | Therapeutic cooling devices |
DE60023118T2 (en) | 1999-01-04 | 2006-07-13 | Medivance, Inc., Louisville | IMPROVED COOLING / HEATING CUSHION AND SYSTEM |
US6183773B1 (en) | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
US6306119B1 (en) | 1999-01-20 | 2001-10-23 | Pearl Technology Holdings, Llc | Skin resurfacing and treatment using biocompatible materials |
US6592577B2 (en) | 1999-01-25 | 2003-07-15 | Cryocath Technologies Inc. | Cooling system |
US6635053B1 (en) | 1999-01-25 | 2003-10-21 | Cryocath Technologies Inc. | Cooling system |
ATE216875T1 (en) | 1999-01-27 | 2002-05-15 | Idea Ag | NON-INVASIVE VACCINATION THROUGH THE SKIN |
AU3286299A (en) | 1999-01-29 | 2000-08-18 | Gerard Hassler | Lowering skin temperature |
US6200308B1 (en) | 1999-01-29 | 2001-03-13 | Candela Corporation | Dynamic cooling of tissue for radiation treatment |
US6468297B1 (en) | 1999-02-24 | 2002-10-22 | Cryovascular Systems, Inc. | Cryogenically enhanced intravascular interventions |
FR2789893B1 (en) | 1999-02-24 | 2001-05-11 | Serge Karagozian | COMBINATION DERMOTONY AND MAGNETOTHERAPY MASSAGE APPARATUS |
US6176869B1 (en) | 1999-02-25 | 2001-01-23 | Breg, Inc. | Fluid drive mechanism for a therapeutic treatment system |
JP4102031B2 (en) | 1999-03-09 | 2008-06-18 | サーメイジ インコーポレイテッド | Apparatus and method for treating tissue |
US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
PT1175749E (en) | 1999-04-22 | 2005-11-30 | Veridicom Inc | HIGH SAFETY BIOMETRIC AUTHENTICATION USING PAIRS OF PUBLIC KEY / PRIVATE KEY ENCRYPTION |
US20040009936A1 (en) | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
WO2000067685A1 (en) | 1999-05-12 | 2000-11-16 | Burns Terrence R | Thermoregulation systems |
US6694170B1 (en) | 1999-05-26 | 2004-02-17 | Endocare, Inc. | Computer guided surgery for prostatic nerve sparing |
US6139544A (en) | 1999-05-26 | 2000-10-31 | Endocare, Inc. | Computer guided cryosurgery |
US20020198518A1 (en) | 1999-05-26 | 2002-12-26 | Mikus Paul W. | Entry position grid for computer guided cryosurgery |
US6643535B2 (en) | 1999-05-26 | 2003-11-04 | Endocare, Inc. | System for providing computer guided ablation of tissue |
US6357907B1 (en) | 1999-06-15 | 2002-03-19 | V & P Scientific, Inc. | Magnetic levitation stirring devices and machines for mixing in vessels |
WO2003053266A2 (en) | 1999-06-30 | 2003-07-03 | Thermage, Inc. | Liquid cooled rf handpiece |
KR200173222Y1 (en) | 1999-07-19 | 2000-03-15 | 이강민 | Supersonic skin massager |
JP2003505190A (en) | 1999-08-02 | 2003-02-12 | ランス ビー. ベッカー, | Methods for inducing hypothermic conditions |
JP2001046416A (en) | 1999-08-10 | 2001-02-20 | Try Company:Kk | Body cooling apparatus |
US6548728B1 (en) | 1999-08-11 | 2003-04-15 | Medical Products, Inc. | Wound dressing garment |
US6290713B1 (en) | 1999-08-24 | 2001-09-18 | Thomas A. Russell | Flexible illuminators for phototherapy |
US7113821B1 (en) | 1999-08-25 | 2006-09-26 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery |
IL131834A0 (en) | 1999-09-09 | 2001-03-19 | M T R E Advanced Technology Lt | Method and system for improving cardiac output of a patient |
US6471693B1 (en) | 1999-09-10 | 2002-10-29 | Cryocath Technologies Inc. | Catheter and system for monitoring tissue contact |
US6226996B1 (en) | 1999-10-06 | 2001-05-08 | Paul J. Weber | Device for controlled cooling of a surface |
GB9923804D0 (en) | 1999-10-08 | 1999-12-08 | Hewlett Packard Co | Electronic commerce system |
WO2001032114A1 (en) | 1999-11-02 | 2001-05-10 | Wizcare Ltd. | Skin-gripper |
GB2356145B (en) | 1999-11-10 | 2004-07-28 | Mas Mfg Ltd | Dressing |
US6743222B2 (en) | 1999-12-10 | 2004-06-01 | Candela Corporation | Method of treating disorders associated with sebaceous follicles |
US6402775B1 (en) | 1999-12-14 | 2002-06-11 | Augustine Medical, Inc. | High-efficiency cooling pads, mattresses, and sleeves |
JP2004159666A (en) | 1999-12-21 | 2004-06-10 | Ya Man Ltd | Laser epilation device |
JP4723707B2 (en) | 1999-12-22 | 2011-07-13 | パナソニック電工株式会社 | Slimming equipment |
US6699237B2 (en) | 1999-12-30 | 2004-03-02 | Pearl Technology Holdings, Llc | Tissue-lifting device |
JP2001190586A (en) | 2000-01-11 | 2001-07-17 | Ohiro Seisakusho:Kk | Facial treatment implement |
US6840955B2 (en) | 2000-01-27 | 2005-01-11 | Robert J. Ein | Therapeutic apparatus |
US6551251B2 (en) | 2000-02-14 | 2003-04-22 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Passive fetal heart monitoring system |
FR2805989B1 (en) | 2000-03-10 | 2003-02-07 | Prod Ella Bache Laboratoire Su | PROCESS FOR TREATING INESTHETISMS OF SILHOUETTE OF THE HUMAN BODY AND DEVICE FOR IMPLEMENTING THE METHOD |
AU2001252914A1 (en) | 2000-03-14 | 2001-09-24 | Alnis Bioscience, Inc. | Cryoprotective system |
KR100367639B1 (en) | 2000-03-20 | 2003-01-14 | 안문휘 | Cryogenic stimulating device of acupuncture points |
US6311497B1 (en) | 2000-03-22 | 2001-11-06 | Young-Chun Chung | Device for cold and warm formentations |
US20020188478A1 (en) | 2000-03-24 | 2002-12-12 | Joe Breeland | Health-care systems and methods |
US6354099B1 (en) | 2000-04-11 | 2002-03-12 | Augustine Medical, Inc. | Cooling devices with high-efficiency cooling features |
ATE372754T1 (en) | 2000-04-20 | 2007-09-15 | Univ Leland Stanford Junior | METHOD AND DEVICE FOR COOLING THE BODY CORE |
US20020151830A1 (en) | 2000-04-28 | 2002-10-17 | Rocky Kahn | Hydrotherapy system with water pervious body support |
US6494844B1 (en) | 2000-06-21 | 2002-12-17 | Sanarus Medical, Inc. | Device for biopsy and treatment of breast tumors |
AU2001276895A1 (en) | 2000-07-13 | 2002-01-30 | Medtronic, Inc. | Non-invasive carotid cooler brain hypothermia medical device |
US6905492B2 (en) | 2000-07-31 | 2005-06-14 | Galil Medical Ltd. | Planning and facilitation systems and methods for cryosurgery |
US6697670B2 (en) | 2001-08-17 | 2004-02-24 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients |
US8251986B2 (en) | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
US6892099B2 (en) | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
AU2001286515A1 (en) | 2000-08-17 | 2002-02-25 | Robert L. Campbell | Heat exchange element with hydrophilic evaporator surface |
US6795728B2 (en) | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
US6458888B1 (en) | 2000-09-15 | 2002-10-01 | Isp Investments Inc. | Rheology modifier for use in aqueous compositions |
US20040034321A1 (en) | 2000-10-05 | 2004-02-19 | Seacoast Technologies, Inc. | Conformal pad for neurosurgery and method thereof |
US6527765B2 (en) | 2000-10-06 | 2003-03-04 | Charles D. Kelman | Cryogenic surgical system and method of use in removal of tissue |
US6579281B2 (en) | 2000-10-11 | 2003-06-17 | Popcab, Llc | Instrument stabilizer for through-a-port surgery |
US6540694B1 (en) | 2000-10-16 | 2003-04-01 | Sanarus Medical, Inc. | Device for biopsy tumors |
JP3655820B2 (en) | 2000-10-23 | 2005-06-02 | 繁雄 小林 | Head cooling and heating device |
EP1201266A1 (en) | 2000-10-26 | 2002-05-02 | Compex SA | Method for programming stimulation data into a stimulation device |
DE10056242A1 (en) | 2000-11-14 | 2002-05-23 | Alstom Switzerland Ltd | Condensation heat exchanger has heat exchanger surfaces having a coating consisting of a alternating sequence of layers made up of a hard layer with amorphous carbon or a plasma polymer |
US6821274B2 (en) | 2001-03-07 | 2004-11-23 | Gendel Ltd. | Ultrasound therapy for selective cell ablation |
US7549987B2 (en) | 2000-12-09 | 2009-06-23 | Tsunami Medtech, Llc | Thermotherapy device |
US6626854B2 (en) | 2000-12-27 | 2003-09-30 | Insightec - Txsonics Ltd. | Systems and methods for ultrasound assisted lipolysis |
US6645162B2 (en) | 2000-12-27 | 2003-11-11 | Insightec - Txsonics Ltd. | Systems and methods for ultrasound assisted lipolysis |
US7351252B2 (en) | 2002-06-19 | 2008-04-01 | Palomar Medical Technologies, Inc. | Method and apparatus for photothermal treatment of tissue at depth |
EP1347711B1 (en) | 2000-12-28 | 2006-11-15 | Palomar Medical Technologies, Inc. | Apparatus for therapeutic emr treatment of the skin |
US7347855B2 (en) | 2001-10-29 | 2008-03-25 | Ultrashape Ltd. | Non-invasive ultrasonic body contouring |
JP4727903B2 (en) | 2001-01-03 | 2011-07-20 | ウルトラシェイプ リミティド | Non-invasive ultrasound body contouring |
US6607498B2 (en) | 2001-01-03 | 2003-08-19 | Uitra Shape, Inc. | Method and apparatus for non-invasive body contouring by lysing adipose tissue |
US6551348B1 (en) | 2001-01-26 | 2003-04-22 | Deroyal Industries, Inc. | Temperature controlled fluid therapy system |
JP2002224051A (en) | 2001-01-30 | 2002-08-13 | Yamaguchi Prefecture | Nonrestraint life monitor |
US20050145372A1 (en) | 2004-01-02 | 2005-07-07 | Noel Thomas P. | Method and thermally active multi-phase heat transfer apparatus and method for abstracting heat using liquid bi-phase heat exchanging composition |
US6904956B2 (en) | 2002-10-18 | 2005-06-14 | Thomas P. Noel | Method and thermally active convection apparatus and method for abstracting heat with circulation intermediate three dimensional-parity heat transfer elements in bi-phase heat exchanging composition |
JP4027049B2 (en) | 2001-02-28 | 2007-12-26 | 株式会社ニデック | Laser therapy device |
US6948903B2 (en) | 2001-03-15 | 2005-09-27 | Maxon Lift Corporation | Unitary liftgate |
JP4938177B2 (en) | 2001-03-22 | 2012-05-23 | 小林製薬株式会社 | Cold / warm pad |
JP2002290397A (en) | 2001-03-23 | 2002-10-04 | Iryo Joho Syst Kaihatsu Center | Secure communication method |
US7083580B2 (en) | 2001-04-06 | 2006-08-01 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US20020156509A1 (en) | 2001-04-23 | 2002-10-24 | Stephen Cheung | Thermal control suit |
WO2002087700A1 (en) * | 2001-04-26 | 2002-11-07 | The Procter & Gamble Company | Method, kit and device for the treatment of cosmetic skin conditions |
FR2823973B1 (en) | 2001-04-27 | 2003-12-26 | Alain Meunier | MASSAGE APPARATUS FOR PERFORMING "PRESS-PRESS-TIRE" MASSAGE |
US6438954B1 (en) | 2001-04-27 | 2002-08-27 | 3M Innovative Properties Company | Multi-directional thermal actuator |
US6430956B1 (en) | 2001-05-15 | 2002-08-13 | Cimex Biotech Lc | Hand-held, heat sink cryoprobe, system for heat extraction thereof, and method therefore |
GB0111986D0 (en) | 2001-05-16 | 2001-07-04 | Optomed As | Cryosurgical apparatus and methods |
CN2514795Y (en) | 2001-05-18 | 2002-10-09 | 郑晓丹 | Multi-contact freezing beautifying pencil |
US7192426B2 (en) | 2001-05-31 | 2007-03-20 | Endocare, Inc. | Cryogenic system |
US20020188286A1 (en) | 2001-06-06 | 2002-12-12 | Quijano Rodolfo C. | Methods for treating vulnerable plaque |
US6551341B2 (en) | 2001-06-14 | 2003-04-22 | Advanced Cardiovascular Systems, Inc. | Devices configured from strain hardened Ni Ti tubing |
FR2826107A1 (en) | 2001-06-19 | 2002-12-20 | M D I C | Cold pack useful for cryotherapy or food preservation comprises sealed flexible casing containing aqueous composition, hydrocolloid thickener and freezing point depressant |
AU2001267804B2 (en) | 2001-06-27 | 2007-05-31 | Radiancy Inc. | Acne treatment |
TW476644B (en) | 2001-06-28 | 2002-02-21 | Wen-Hu Liau | Portable first-aid cold hot compress pack |
JP3393128B1 (en) | 2001-07-18 | 2003-04-07 | 正雄 酒井 | Female wearing condom |
CN2514811Y (en) | 2001-07-31 | 2002-10-09 | 尹旭光 | Electrothermal device for heatig foot |
US20030032900A1 (en) | 2001-08-08 | 2003-02-13 | Engii (2001) Ltd. | System and method for facial treatment |
US20040260210A1 (en) | 2003-06-23 | 2004-12-23 | Engii (2001) Ltd. | System and method for face and body treatment |
US20040260209A1 (en) | 2003-06-23 | 2004-12-23 | Engli (2001) Ltd. | System and method for face and body treatment |
US6438964B1 (en) | 2001-09-10 | 2002-08-27 | Percy Giblin | Thermoelectric heat pump appliance with carbon foam heat sink |
US6572450B2 (en) | 2001-09-21 | 2003-06-03 | Iphotonics, Inc. | Roll format polishing process for optical devices |
US20030062040A1 (en) | 2001-09-28 | 2003-04-03 | Lurie Keith G. | Face mask ventilation/perfusion systems and method |
US20030114885A1 (en) | 2001-10-02 | 2003-06-19 | Nova Richard C. | System and device for implementing an integrated medical device component package |
CN1305914C (en) | 2001-10-05 | 2007-03-21 | 巴斯福股份公司 | Method for crosslinking hydrogels with morpholine-2,3-diones |
US6699267B2 (en) | 2001-10-11 | 2004-03-02 | Medivance Incorporated | Patient temperature control system with fluid temperature response |
US6660027B2 (en) | 2001-10-11 | 2003-12-09 | Medivance Incorporated | Patient temperature control system with fluid preconditioning |
US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
US20030125649A1 (en) | 2001-10-31 | 2003-07-03 | Mcintosh Laura Janet | Method and system apparatus using temperature and pressure for treating medical disorders |
EP1454241B1 (en) | 2001-11-20 | 2012-10-10 | Western Digital Technologies, Inc. | Method of secure transfer of data between firewall-protected devices |
US6889090B2 (en) | 2001-11-20 | 2005-05-03 | Syneron Medical Ltd. | System and method for skin treatment using electrical current |
US6648904B2 (en) | 2001-11-29 | 2003-11-18 | Palomar Medical Technologies, Inc. | Method and apparatus for controlling the temperature of a surface |
US6849075B2 (en) | 2001-12-04 | 2005-02-01 | Estech, Inc. | Cardiac ablation devices and methods |
US6699266B2 (en) | 2001-12-08 | 2004-03-02 | Charles A. Lachenbruch | Support surface with phase change material or heat tubes |
US20030109910A1 (en) | 2001-12-08 | 2003-06-12 | Lachenbruch Charles A. | Heating or cooling pad or glove with phase change material |
US6755852B2 (en) | 2001-12-08 | 2004-06-29 | Charles A. Lachenbruch | Cooling body wrap with phase change material |
EP1627662B1 (en) | 2004-06-10 | 2011-03-02 | Candela Corporation | Apparatus for vacuum-assisted light-based treatments of the skin |
US7762965B2 (en) | 2001-12-10 | 2010-07-27 | Candela Corporation | Method and apparatus for vacuum-assisted light-based treatments of the skin |
JP2003190201A (en) | 2001-12-26 | 2003-07-08 | Lion Corp | Body cooler and body warmer |
JP4551090B2 (en) | 2002-02-20 | 2010-09-22 | メディシス テクノロジーズ コーポレイション | Ultrasonic treatment and imaging of adipose tissue |
US6523354B1 (en) | 2002-03-08 | 2003-02-25 | Deborah Ann Tolbert | Cooling blanket |
EP1917935B1 (en) | 2002-03-15 | 2011-01-12 | The General Hospital Corporation | Method for selective disruption of fatty tissue by controlled cooling |
US8840608B2 (en) | 2002-03-15 | 2014-09-23 | The General Hospital Corporation | Methods and devices for selective disruption of fatty tissue by controlled cooling |
US6662054B2 (en) | 2002-03-26 | 2003-12-09 | Syneron Medical Ltd. | Method and system for treating skin |
US20030236487A1 (en) | 2002-04-29 | 2003-12-25 | Knowlton Edward W. | Method for treatment of tissue with feedback |
US20040176667A1 (en) | 2002-04-30 | 2004-09-09 | Mihai Dan M. | Method and system for medical device connectivity |
USD471982S1 (en) | 2002-05-03 | 2003-03-18 | Ming-Chuan Cheng | Oxygen concentrator |
US20030220594A1 (en) | 2002-05-24 | 2003-11-27 | United States Manufacturing Company, Inc. | Torso orthosis apparatus and method |
US6746474B2 (en) | 2002-05-31 | 2004-06-08 | Vahid Saadat | Apparatus and methods for cooling a region within the body |
EP1505765A4 (en) | 2002-06-07 | 2006-10-04 | Sony Corp | Data processing system, data processing device, data processing method, and computer program |
JP3786055B2 (en) | 2002-06-07 | 2006-06-14 | ソニー株式会社 | Data processing system, data processing apparatus and method, and computer program |
KR20050026404A (en) | 2002-06-19 | 2005-03-15 | 팔로마 메디칼 테크놀로지스, 인코포레이티드 | Method and apparatus for photothermal treatment of tissue at depth |
JP2004073812A (en) | 2002-06-20 | 2004-03-11 | Ya Man Ltd | Massager |
US7331951B2 (en) | 2002-06-25 | 2008-02-19 | Ultrashape Inc. | Devices and methodologies useful in body aesthetics |
US6820961B2 (en) | 2002-06-28 | 2004-11-23 | Lexmark International, Inc. | Stationary ink mist chimney for ink jet printer |
US6969399B2 (en) | 2002-07-11 | 2005-11-29 | Life Recovery Systems Hd, Llc | Apparatus for altering the body temperature of a patient |
US7452712B2 (en) | 2002-07-30 | 2008-11-18 | Applied Biosystems Inc. | Sample block apparatus and method of maintaining a microcard on a sample block |
US7393350B2 (en) | 2002-08-06 | 2008-07-01 | Erbe Elektromedizin Gmbh | Cryo-surgical apparatus and methods |
US7250047B2 (en) | 2002-08-16 | 2007-07-31 | Lumenis Ltd. | System and method for treating tissue |
US6860896B2 (en) | 2002-09-03 | 2005-03-01 | Jeffrey T. Samson | Therapeutic method and apparatus |
US6789545B2 (en) | 2002-10-04 | 2004-09-14 | Sanarus Medical, Inc. | Method and system for cryoablating fibroadenomas |
EP1558339A1 (en) | 2002-10-07 | 2005-08-03 | Palomar Medical Technologies, Inc. | Apparatus for performing photobiostimulation |
US8226698B2 (en) | 2002-10-08 | 2012-07-24 | Vitalwear, Inc. | Therapeutic cranial wrap for a contrast therapy system |
US6994151B2 (en) | 2002-10-22 | 2006-02-07 | Cooligy, Inc. | Vapor escape microchannel heat exchanger |
EP2522294A2 (en) | 2002-10-23 | 2012-11-14 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants and topical substances |
US20040082886A1 (en) | 2002-10-24 | 2004-04-29 | Timpson Sandra Tee | Therapeutic device for relieving pain and stress |
GB2396109B (en) | 2002-12-12 | 2006-04-19 | Johnson & Johnson Medical Ltd | Absorbent multilayer hydrogel wound dressings |
US20040116866A1 (en) | 2002-12-17 | 2004-06-17 | William Gorman | Skin attachment apparatus and method for patient infusion device |
CN1511503A (en) | 2002-12-30 | 2004-07-14 | 中国科学院理化技术研究所 | Fat reducer by applying cold and hot stimulation to skin alternatively |
US7976519B2 (en) | 2002-12-31 | 2011-07-12 | Kci Licensing, Inc. | Externally-applied patient interface system and method |
US6915641B2 (en) | 2003-01-14 | 2005-07-12 | Mark R. Harvie | Personal cooling and heating system |
US7410484B2 (en) | 2003-01-15 | 2008-08-12 | Cryodynamics, Llc | Cryotherapy probe |
ES2442445T3 (en) | 2003-01-15 | 2014-02-11 | Cryodynamics, Llc. | Cryotherapy system |
US7083612B2 (en) | 2003-01-15 | 2006-08-01 | Cryodynamics, Llc | Cryotherapy system |
US7273479B2 (en) | 2003-01-15 | 2007-09-25 | Cryodynamics, Llc | Methods and systems for cryogenic cooling |
US20050143781A1 (en) | 2003-01-31 | 2005-06-30 | Rafael Carbunaru | Methods and systems for patient adjustment of parameters for an implanted stimulator |
US20060234899A1 (en) | 2003-03-05 | 2006-10-19 | H.H. Brown Shoe Technologies Inc. D/B/A Dicon Technologies | Hydrophilic polyurethane foam articles comprising an antimicrobial compound |
JP4435149B2 (en) | 2003-03-06 | 2010-03-17 | トリア ビューティ インコーポレイテッド | Skin contact sensing device |
US7037326B2 (en) | 2003-03-14 | 2006-05-02 | Hee-Young Lee | Skin cooling device using thermoelectric element |
CN2617189Y (en) | 2003-03-22 | 2004-05-26 | 仇刚强 | Antifreezing hand protector |
DE10314138A1 (en) | 2003-03-25 | 2004-10-07 | Krüger & Gothe GmbH | Heating / cooling device |
US20040206365A1 (en) | 2003-03-31 | 2004-10-21 | Knowlton Edward Wells | Method for treatment of tissue |
US9149322B2 (en) | 2003-03-31 | 2015-10-06 | Edward Wells Knowlton | Method for treatment of tissue |
GB0307963D0 (en) | 2003-04-05 | 2003-05-14 | Eastman Kodak Co | A foamed material and a method of making thereof |
US7659301B2 (en) | 2003-04-15 | 2010-02-09 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
US7220778B2 (en) | 2003-04-15 | 2007-05-22 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
US20040210287A1 (en) | 2003-04-21 | 2004-10-21 | Greene Judy L. | Portable cooling or heating device for applying cryotherapy |
KR20040094508A (en) | 2003-05-02 | 2004-11-10 | 김창선 | Apparatus for Skin Treatment Using Ultra-sonic And Cold-Hot |
US20070129441A1 (en) | 2003-05-06 | 2007-06-07 | University Of North Texas Health Science Center At Fort Worth | Protection of cells from adverse external or intrinsic effects, cellular degeneration and death by n-acylethanolamines |
US20040249427A1 (en) | 2003-06-06 | 2004-12-09 | Yunes Nabilsi | Medical cooler device |
US7147610B2 (en) | 2003-06-19 | 2006-12-12 | Tarek Maalouf | Multiple combination heat/massage devices |
JP4504099B2 (en) | 2003-06-25 | 2010-07-14 | 株式会社リコー | Digital certificate management system, digital certificate management apparatus, digital certificate management method, update procedure determination method and program |
US7479104B2 (en) | 2003-07-08 | 2009-01-20 | Maquet Cardiovascular, Llc | Organ manipulator apparatus |
US8100956B2 (en) | 2006-05-09 | 2012-01-24 | Thermotek, Inc. | Method of and system for thermally augmented wound care oxygenation |
EP1646351B1 (en) | 2003-07-18 | 2011-03-30 | Thermotek, Inc. | Thermal system for a blanket |
US20050043723A1 (en) | 2003-08-19 | 2005-02-24 | Schering-Plough Healthcare Products, Inc. | Cryosurgery device |
JP2005065984A (en) | 2003-08-25 | 2005-03-17 | Nikon Corp | Massage machine |
US20050049661A1 (en) | 2003-09-03 | 2005-03-03 | Koffroth Shirley B. | Ice belt to reduce body temperature |
US20050049526A1 (en) | 2003-09-03 | 2005-03-03 | Baer Mark P. | Massage devices and methods thereof |
WO2005023200A2 (en) | 2003-09-09 | 2005-03-17 | Seacost Technologies, Inc. | System and method for cooling internal tissue |
CA2441489A1 (en) | 2003-09-12 | 2005-03-12 | Jocelyn Tortal | Inducing and contouring ice formation |
US7077858B2 (en) | 2003-09-22 | 2006-07-18 | Coolhead Technologies, Inc. | Flexible heat exchangers for medical cooling and warming applications |
JP4640610B2 (en) | 2003-09-30 | 2011-03-02 | ソニー株式会社 | Content acquisition method, acquisition / use information provision method, content acquisition device, acquisition / use information provision device, content acquisition program, and acquisition / use information provision program |
JP2005110755A (en) | 2003-10-03 | 2005-04-28 | Shinko Denshi Kk | Heating/cooling apparatus for reducing muscular fatigue |
US7282036B2 (en) | 2003-10-24 | 2007-10-16 | Masatoshi Masuda | Cosmetic device having vibrator |
EP1527760A1 (en) | 2003-10-29 | 2005-05-04 | Normand, Jacques | Thermal pad and its use |
US7613523B2 (en) | 2003-12-11 | 2009-11-03 | Apsara Medical Corporation | Aesthetic thermal sculpting of skin |
CA2546265A1 (en) | 2003-12-30 | 2005-07-21 | Liposonix, Inc. | Systems and methods for the destruction of adipose tissue |
US7695437B2 (en) | 2003-12-30 | 2010-04-13 | Medicis Technologies Corporation | Ultrasound therapy head with movement control |
US7857773B2 (en) | 2003-12-30 | 2010-12-28 | Medicis Technologies Corporation | Apparatus and methods for the destruction of adipose tissue |
BRPI0418242A (en) | 2003-12-30 | 2007-04-17 | Liposonix Inc | transducer for ultrasound, transducer assemblies and interchangeable electronic medical instruments |
WO2005065407A2 (en) | 2003-12-30 | 2005-07-21 | Liposonix, Inc. | Position tracking device |
US20050149153A1 (en) | 2004-01-07 | 2005-07-07 | Kazuo Nakase | Body temperature adjuster |
US20070141265A1 (en) | 2004-02-02 | 2007-06-21 | Timothy Thomson | Process for controlling the density, conformation and composition of the hydrophilic layer of a polyurethane composite |
JP2005237908A (en) | 2004-02-12 | 2005-09-08 | Tamotsu Nishizaki | Cryosurgical unit using heat exchanger |
US7052167B2 (en) | 2004-02-25 | 2006-05-30 | Vanderschuit Carl R | Therapeutic devices and methods for applying therapy |
JP4109640B2 (en) | 2004-02-25 | 2008-07-02 | 株式会社エム・アイ・ラボ | Automatic excitation massager |
US20060035380A1 (en) | 2004-03-12 | 2006-02-16 | L'oreal | Fake-proof marking of a composition |
USD546949S1 (en) | 2004-03-24 | 2007-07-17 | Maxima Air Separation Center Ltd. | Device for transporting canisters of gas |
JP2005312950A (en) | 2004-03-31 | 2005-11-10 | Terumo Corp | Medical tool for energy irradiation and medical energy irradiation device |
AU2005231443B2 (en) | 2004-04-01 | 2012-02-23 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
JP4971133B2 (en) | 2004-04-01 | 2012-07-11 | ザ ジェネラル ホスピタル コーポレイション | Equipment for dermatological treatment |
US20070179482A1 (en) | 2004-05-07 | 2007-08-02 | Anderson Robert S | Apparatuses and methods to treat biological external tissue |
US20050251117A1 (en) | 2004-05-07 | 2005-11-10 | Anderson Robert S | Apparatus and method for treating biological external tissue |
US7842029B2 (en) | 2004-05-07 | 2010-11-30 | Aesthera | Apparatus and method having a cooling material and reduced pressure to treat biological external tissue |
US8571648B2 (en) | 2004-05-07 | 2013-10-29 | Aesthera | Apparatus and method to apply substances to tissue |
JP2005323716A (en) | 2004-05-13 | 2005-11-24 | Takeshi Shimizu | Cold spot stimulation device |
WO2005113005A2 (en) | 2004-05-20 | 2005-12-01 | The United States Of America As Represented By The Secretary Of The Army | Transcutaneous and/or transdermal transport of materials |
US20050277859A1 (en) | 2004-05-27 | 2005-12-15 | Carlsmith Bruce S | Joint protection device |
US7959657B1 (en) | 2004-07-07 | 2011-06-14 | Harsy Douglas R | Portable thermal therapeutic apparatus and method |
JP4579603B2 (en) | 2004-07-14 | 2010-11-10 | 株式会社リブドゥコーポレーション | Non-woven fabric for skin cleaning |
US20060036300A1 (en) | 2004-08-16 | 2006-02-16 | Syneron Medical Ltd. | Method for lypolisis |
US7171508B2 (en) | 2004-08-23 | 2007-01-30 | Micron Technology, Inc. | Dual port memory with asymmetric inputs and outputs, device, system and method |
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US7241263B2 (en) | 2004-09-30 | 2007-07-10 | Scimed Life Systems, Inc. | Selectively rotatable shaft coupler |
US8690779B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Noninvasive aesthetic treatment for tightening tissue |
KR101328103B1 (en) | 2004-10-06 | 2013-11-13 | 가이디드 테라피 시스템스, 엘.엘.씨. | Method and system for noninvasive cosmetic enhancement |
US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
KR20130080477A (en) | 2004-10-06 | 2013-07-12 | 가이디드 테라피 시스템스, 엘.엘.씨. | System of ultrasound treatment |
US8663112B2 (en) | 2004-10-06 | 2014-03-04 | Guided Therapy Systems, Llc | Methods and systems for fat reduction and/or cellulite treatment |
US8133180B2 (en) | 2004-10-06 | 2012-03-13 | Guided Therapy Systems, L.L.C. | Method and system for treating cellulite |
US20120016239A1 (en) | 2004-10-06 | 2012-01-19 | Guided Therapy Systems, Llc | Systems for cosmetic treatment |
USD525592S1 (en) | 2004-10-18 | 2006-07-25 | Mold-Masters Limited | Controller |
US20060094988A1 (en) | 2004-10-28 | 2006-05-04 | Tosaya Carol A | Ultrasonic apparatus and method for treating obesity or fat-deposits or for delivering cosmetic or other bodily therapy |
JP4324673B2 (en) | 2004-11-05 | 2009-09-02 | 国立大学法人東北大学 | Cryotherapy device with Peltier module |
US20060122509A1 (en) | 2004-11-24 | 2006-06-08 | Liposonix, Inc. | System and methods for destroying adipose tissue |
US7828831B1 (en) | 2004-12-06 | 2010-11-09 | Deroyal Industries, Inc. | Hot and cold fluid therapy system |
US7780656B2 (en) | 2004-12-10 | 2010-08-24 | Reliant Technologies, Inc. | Patterned thermal treatment using patterned cryogen spray and irradiation by light |
GB2422109B (en) | 2005-01-13 | 2007-02-21 | Richard Mills | Apparatus for providing a heating and cooling effect |
JP2008536527A (en) | 2005-01-24 | 2008-09-11 | キネティキュア リミテッド | Apparatus and method for applying vibration to a joint |
US7871427B2 (en) | 2005-02-08 | 2011-01-18 | Carewave, Inc. | Apparatus and method for using a portable thermal device to reduce accommodation of nerve receptors |
US7458808B2 (en) | 2005-02-22 | 2008-12-02 | Woodlane Environmental Technology, Inc. | Gel fuel log set |
US8500661B2 (en) | 2005-03-09 | 2013-08-06 | Allan Ronald Greenberg | Apparatus and method of body contouring and skin conditioning |
US8801701B2 (en) | 2005-03-09 | 2014-08-12 | Sunnybrook Health Sciences Centre | Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment |
US20060206040A1 (en) | 2005-03-09 | 2006-09-14 | Greenberg Ronald A | aparatus and method of body contouring and skin conditioning using a mobile suction device |
US9581942B1 (en) | 2005-03-23 | 2017-02-28 | Shippert Enterprises, Llc | Tissue transfer method and apparatus |
KR20070115863A (en) | 2005-03-31 | 2007-12-06 | 가부시키가이샤 니콘 | Exposure method, exposure apparatus and device manufacturing method |
US7975702B2 (en) | 2005-04-05 | 2011-07-12 | El.En. S.P.A. | System and method for laser lipolysis |
AU2006239290B2 (en) | 2005-04-27 | 2012-05-10 | Zoll Circulation, Inc. | System for adjusting the temperature of a patient |
US7217265B2 (en) | 2005-05-18 | 2007-05-15 | Cooltouch Incorporated | Treatment of cellulite with mid-infrared radiation |
US7713266B2 (en) | 2005-05-20 | 2010-05-11 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
US7850683B2 (en) | 2005-05-20 | 2010-12-14 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
WO2006127897A2 (en) | 2005-05-24 | 2006-11-30 | Uab Research Foundation | Surgical delivery devices and methods |
CN2843367Y (en) | 2005-07-01 | 2006-12-06 | 李铁军 | The refrigerating plant that is used for the treatment of skin vegetations |
US8181262B2 (en) | 2005-07-20 | 2012-05-15 | Verimatrix, Inc. | Network user authentication system and method |
US7955262B2 (en) | 2005-07-26 | 2011-06-07 | Syneron Medical Ltd. | Method and apparatus for treatment of skin using RF and ultrasound energies |
US20070032561A1 (en) | 2005-08-05 | 2007-02-08 | I-Sioun Lin | Modified hydrophilic polyurethane memory foam, application and manufacturing method thereof |
US20070055173A1 (en) | 2005-08-23 | 2007-03-08 | Sanarus Medical, Inc. | Rotational core biopsy device with liquid cryogen adhesion probe |
CN2850585Y (en) | 2005-09-05 | 2006-12-27 | 李钟俊 | Novel freezing skin-softening cosmetic instrument with magnetic field |
CN2850584Y (en) | 2005-09-05 | 2006-12-27 | 李钟俊 | Freezing skin-softening cosmetic instrument |
US7967763B2 (en) | 2005-09-07 | 2011-06-28 | Cabochon Aesthetics, Inc. | Method for treating subcutaneous tissues |
GB2431108A (en) | 2005-09-07 | 2007-04-18 | Mohammed Firoz Hussein | Applicator for dispensing cryogenic fluid |
US8518069B2 (en) | 2005-09-07 | 2013-08-27 | Cabochon Aesthetics, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9028469B2 (en) | 2005-09-28 | 2015-05-12 | Candela Corporation | Method of treating cellulite |
US20070078502A1 (en) | 2005-10-05 | 2007-04-05 | Thermage, Inc. | Method and apparatus for estimating a local impedance factor |
US7572268B2 (en) | 2005-10-13 | 2009-08-11 | Bacoustics, Llc | Apparatus and methods for the selective removal of tissue using combinations of ultrasonic energy and cryogenic energy |
US7729773B2 (en) | 2005-10-19 | 2010-06-01 | Advanced Neuromodualation Systems, Inc. | Neural stimulation and optical monitoring systems and methods |
US8702691B2 (en) | 2005-10-19 | 2014-04-22 | Thermage, Inc. | Treatment apparatus and methods for delivering energy at multiple selectable depths in tissue |
WO2007056493A1 (en) | 2005-11-08 | 2007-05-18 | Schumann Daniel H | Device and method for the treatment of pain with electrical energy |
US20080014627A1 (en) | 2005-12-02 | 2008-01-17 | Cabochon Aesthetics, Inc. | Devices and methods for selectively lysing cells |
US20080195036A1 (en) | 2005-12-02 | 2008-08-14 | Cabochon Aesthetics, Inc. | Devices and methods for selectively lysing cells |
US9248317B2 (en) | 2005-12-02 | 2016-02-02 | Ulthera, Inc. | Devices and methods for selectively lysing cells |
US20070135876A1 (en) | 2005-12-08 | 2007-06-14 | Weber Paul J | Acne and skin defect treatment via non-radiofrequency electrical current controlled power delivery device and methods |
US7799018B2 (en) | 2006-01-06 | 2010-09-21 | Olga Goulko | Cryogenic applicator for rejuvenating human skin and related method |
US20090312676A1 (en) | 2006-02-02 | 2009-12-17 | Tylerton International Inc. | Metabolic Sink |
CN100362067C (en) | 2006-02-08 | 2008-01-16 | 舒宏纪 | Interface paint with high hydrophobicity, heat conductivity and adhesion |
US7824437B1 (en) | 2006-02-13 | 2010-11-02 | Gina Saunders | Multi-functional abdominal cramp reducing device and associated method |
WO2007098094A2 (en) | 2006-02-16 | 2007-08-30 | Polacek Denise C | Thermoelectric cooler and reservoir for medical treatment |
US8133191B2 (en) | 2006-02-16 | 2012-03-13 | Syneron Medical Ltd. | Method and apparatus for treatment of adipose tissue |
US7854754B2 (en) | 2006-02-22 | 2010-12-21 | Zeltiq Aesthetics, Inc. | Cooling device for removing heat from subcutaneous lipid-rich cells |
GB0605107D0 (en) | 2006-03-14 | 2006-04-26 | Bioforskning As | Use |
JP4903471B2 (en) | 2006-03-30 | 2012-03-28 | 東急建設株式会社 | Building wall material and wireless transmission system |
US20070249519A1 (en) | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
US20070255187A1 (en) | 2006-04-26 | 2007-11-01 | Branch Alan P | Vibrating therapy device |
CN101351167B (en) | 2006-04-28 | 2014-04-02 | 斯尔替克美学股份有限公司 | Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells |
US7615036B2 (en) | 2006-05-11 | 2009-11-10 | Kalypto Medical, Inc. | Device and method for wound therapy |
US20070282318A1 (en) | 2006-05-16 | 2007-12-06 | Spooner Gregory J | Subcutaneous thermolipolysis using radiofrequency energy |
US20070270925A1 (en) | 2006-05-17 | 2007-11-22 | Juniper Medical, Inc. | Method and apparatus for non-invasively removing heat from subcutaneous lipid-rich cells including a coolant having a phase transition temperature |
KR100746322B1 (en) | 2006-06-12 | 2007-08-06 | 주식회사 바이오스마트 | Rod type skin treatment device for cryo-surgery and cryo-skin treatment |
KR100746323B1 (en) | 2006-06-12 | 2007-08-06 | 주식회사 바이오스마트 | Roller type skin treatment device for cryo-surgery and cryo-skin treatment |
US8246611B2 (en) | 2006-06-14 | 2012-08-21 | Candela Corporation | Treatment of skin by spatial modulation of thermal heating |
FR2902645B1 (en) | 2006-06-22 | 2008-10-03 | Louisin Researhc Dev Ltd | DEVICE FOR THE TREATMENT, IN PARTICULAR OF MASSAGE, OF THE CONNECTIVE TISSUE OF THE SKIN |
US8460352B2 (en) | 2006-07-05 | 2013-06-11 | Kaz Usa, Inc. | Site-specific pad with notch |
USD550362S1 (en) | 2006-07-26 | 2007-09-04 | Alcon, Inc. | Surgical console |
US20080046047A1 (en) | 2006-08-21 | 2008-02-21 | Daniel Jacobs | Hot and cold therapy device |
EP2059215B1 (en) | 2006-08-28 | 2015-12-02 | Gerard Hassler | Improved preparation for reducing and/or preventing body fat and respective uses, in particular together with a dressing material |
US20090171253A1 (en) | 2006-09-06 | 2009-07-02 | Cutera, Inc. | System and method for dermatological treatment using ultrasound |
ATE489048T1 (en) | 2006-09-08 | 2010-12-15 | Arbel Medical Ltd | DEVICE FOR COMBINED TREATMENT |
US20080097207A1 (en) | 2006-09-12 | 2008-04-24 | Siemens Medical Solutions Usa, Inc. | Ultrasound therapy monitoring with diagnostic ultrasound |
US9132031B2 (en) | 2006-09-26 | 2015-09-15 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
US8192474B2 (en) | 2006-09-26 | 2012-06-05 | Zeltiq Aesthetics, Inc. | Tissue treatment methods |
US20080077201A1 (en) | 2006-09-26 | 2008-03-27 | Juniper Medical, Inc. | Cooling devices with flexible sensors |
ITMI20061918A1 (en) | 2006-10-06 | 2008-04-07 | Nanovector S R L | SUITABLE FORMULATIONS TO BE GIVEN BY TRANSDERMIC CONTAINING ACTIVE INGREDIENTS IN SLN |
JP2010508130A (en) | 2006-10-31 | 2010-03-18 | ゼルティック エステティックス インコーポレイテッド | Method and apparatus for cooling subcutaneous high lipid cells or subcutaneous high lipid tissue |
CN200970265Y (en) | 2006-11-09 | 2007-11-07 | 韩秀玲 | Freezing therapeutic device |
US20080114348A1 (en) | 2006-11-13 | 2008-05-15 | Vancelette David W | Cryoprotective Agent Delivery |
US20080140371A1 (en) | 2006-11-15 | 2008-06-12 | General Electric Company | System and method for treating a patient |
US20100028969A1 (en) | 2006-12-18 | 2010-02-04 | Koninklijke Philips Electronics N.V. | Cell lysis or electroporation device comprising at least one pyroelectric material |
US9254162B2 (en) | 2006-12-21 | 2016-02-09 | Myoscience, Inc. | Dermal and transdermal cryogenic microprobe systems |
US20080161892A1 (en) | 2006-12-28 | 2008-07-03 | John Anthony Mercuro | Facial Cold -Pack Holder |
US8128401B2 (en) | 2006-12-29 | 2012-03-06 | Clifford J. Ruddle | Cannula for a combined dental irrigator and vacuum device |
US8267983B2 (en) | 2007-01-11 | 2012-09-18 | Scion Neurostim, Llc. | Medical devices incorporating thermoelectric transducer and controller |
US20080208181A1 (en) | 2007-01-19 | 2008-08-28 | Arbel Medical Ltd. | Thermally Insulated Needles For Dermatological Applications |
KR20090000258A (en) | 2007-02-08 | 2009-01-07 | 황보의 | Target education system and education method thereof |
US8414631B2 (en) | 2007-02-13 | 2013-04-09 | Thermotek, Inc. | System and method for cooled airflow for dermatological applications |
JP2010534076A (en) | 2007-02-16 | 2010-11-04 | ケー. パール,ポール | An apparatus and method that applies non-invasive ultrasound to shape the body using skin contact cooling. |
CN101259329A (en) | 2007-03-08 | 2008-09-10 | 德切勒·克里斯托夫·迪亚特曼 | Plush toy warming device |
US20090016980A1 (en) * | 2007-03-26 | 2009-01-15 | Irina Tsivkin | Method of Pre-Treating Hair Prior to Coloring |
USD568258S1 (en) | 2007-04-06 | 2008-05-06 | Zeltiq Aesthetics, Inc. | Control unit |
CN101711134B (en) | 2007-04-19 | 2016-08-17 | 米勒玛尔实验室公司 | Tissue is applied the system of microwave energy and in organized layer, produces the system of tissue effect |
US8688228B2 (en) | 2007-04-19 | 2014-04-01 | Miramar Labs, Inc. | Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy |
EP3391844A1 (en) | 2007-04-19 | 2018-10-24 | Miramar Labs, Inc. | Apparatus for reducing sweat production |
US9241763B2 (en) | 2007-04-19 | 2016-01-26 | Miramar Labs, Inc. | Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy |
US20080287839A1 (en) | 2007-05-18 | 2008-11-20 | Juniper Medical, Inc. | Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator |
WO2008151260A2 (en) | 2007-06-04 | 2008-12-11 | Farr Laboratories, Llc | Skin care method and kit using peltier thermoelectric device |
WO2008154000A1 (en) | 2007-06-08 | 2008-12-18 | Cynosure, Inc. | Thermal surgery safety suite |
US20080312651A1 (en) | 2007-06-15 | 2008-12-18 | Karl Pope | Apparatus and methods for selective heating of tissue |
US20090012434A1 (en) | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
KR20090000258U (en) | 2007-07-06 | 2009-01-09 | 주식회사 바이오스마트 | Roller type skin treatment device for cryo-surgery and cryo-skin treatment |
US20090018625A1 (en) | 2007-07-13 | 2009-01-15 | Juniper Medical, Inc. | Managing system temperature to remove heat from lipid-rich regions |
US20090018627A1 (en) | 2007-07-13 | 2009-01-15 | Juniper Medical, Inc. | Secure systems for removing heat from lipid-rich regions |
US8523927B2 (en) | 2007-07-13 | 2013-09-03 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
US20090018624A1 (en) | 2007-07-13 | 2009-01-15 | Juniper Medical, Inc. | Limiting use of disposable system patient protection devices |
EP2182872A1 (en) | 2007-07-13 | 2010-05-12 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
US20090018626A1 (en) | 2007-07-13 | 2009-01-15 | Juniper Medical, Inc. | User interfaces for a system that removes heat from lipid-rich regions |
US8285390B2 (en) | 2007-08-21 | 2012-10-09 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
ATE547991T1 (en) | 2007-08-24 | 2012-03-15 | Ellipse As | SKIN COOLING FOR A DERMATOLOGICAL TREATMENT PROCEDURE |
US8433400B2 (en) | 2007-10-24 | 2013-04-30 | Marina Prushinskaya | Method and portable device for treating skin disorders |
US20090111736A1 (en) | 2007-10-29 | 2009-04-30 | Sri International | Orally-Absorbed Solid Dose Formulation for Vancomycin |
US20090118684A1 (en) * | 2007-11-05 | 2009-05-07 | Da Silva Luiz B | Thermal personal care systems and methods |
US20090149930A1 (en) | 2007-12-07 | 2009-06-11 | Thermage, Inc. | Apparatus and methods for cooling a treatment apparatus configured to non-invasively deliver electromagnetic energy to a patient's tissue |
ES2471971T3 (en) | 2007-12-12 | 2014-06-27 | Miramar Labs, Inc. | System and apparatus for non-invasive treatment of tissue using microwave energy |
CA2713939C (en) | 2008-02-01 | 2017-12-05 | Alma Lasers Ltd. | Apparatus and method for selective ultrasonic damage of adipocytes |
JP2009189757A (en) | 2008-02-15 | 2009-08-27 | Akira Hirai | Fever relieving device |
US20090228082A1 (en) | 2008-03-07 | 2009-09-10 | Smiths Medical Asd, Inc. | Patient heat transfer device |
US8461108B2 (en) | 2008-03-07 | 2013-06-11 | Myoscience, Inc. | Subdermal tissue remodeling using myostatin, methods and related systems |
EP2280675B1 (en) | 2008-04-30 | 2014-04-23 | Eric William Brader | Apparatus for preventing brain damage during cardiac arrest, cpr, or severe shock |
US8961441B2 (en) | 2008-05-07 | 2015-02-24 | Sanuwave, Inc. | Medical treatment system including an ancillary medical treatment apparatus with an associated data storage medium |
US20180104094A9 (en) | 2008-05-16 | 2018-04-19 | Seth A. Biser | Thermal eye compress systems and methods of use |
US20090299234A1 (en) | 2008-05-28 | 2009-12-03 | Nuga Medical Co., Ltd | Fat remover |
CA3206234A1 (en) | 2008-06-06 | 2009-12-10 | Ulthera, Inc. | A system and method for cosmetic treatment and imaging |
US20090306749A1 (en) | 2008-06-07 | 2009-12-10 | Damalie Mulindwa | Therapeutic hot and cold water belt |
US20090312693A1 (en) | 2008-06-13 | 2009-12-17 | Vytronus, Inc. | System and method for delivering energy to tissue |
US8285392B2 (en) | 2008-06-19 | 2012-10-09 | Thermage, Inc. | Leakage-resistant tissue treatment apparatus and methods of using such tissue treatment apparatus |
WO2010017556A1 (en) * | 2008-08-08 | 2010-02-11 | Palomar Medical Technologies, Inc | Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue |
US8672931B2 (en) * | 2008-08-18 | 2014-03-18 | 3JT Enterprises, LLC | Cryosurgical device with metered dose |
US9149386B2 (en) | 2008-08-19 | 2015-10-06 | Niveus Medical, Inc. | Devices and systems for stimulation of tissues |
WO2010028409A1 (en) | 2008-09-03 | 2010-03-11 | Dobson, Melissa, K. | A cryogenic system and method of use |
US8409184B2 (en) | 2009-09-09 | 2013-04-02 | Cpsi Holdings Llc | Cryo-medical injection device and method of use |
EP2346428B1 (en) | 2008-09-25 | 2019-11-06 | Zeltiq Aesthetics, Inc. | Treatment planning systems and methods for body contouring applications |
US20100087806A1 (en) | 2008-10-07 | 2010-04-08 | Vandolay, Inc. | Automated Cryogenic Skin Treatment |
US20100217357A1 (en) | 2008-10-31 | 2010-08-26 | Da Silva Luiz B | Methods and Apparatus for Personal Care |
US8387631B1 (en) | 2008-12-10 | 2013-03-05 | Western Digital Technologies, Inc. | HDA vacuum cleaning machine for manufacturing of HDD |
US8603073B2 (en) | 2008-12-17 | 2013-12-10 | Zeltiq Aesthetics, Inc. | Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells |
CA2748022A1 (en) | 2008-12-22 | 2010-07-01 | Myoscience, Inc. | Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments |
US20100168726A1 (en) | 2008-12-31 | 2010-07-01 | Marc Arthur Brookman | Cryogenic Dispensing System and Method for Treatment of Dermatological Conditions |
US7981080B2 (en) | 2009-01-07 | 2011-07-19 | Halaka Folim G | Skin cooling apparatus and method |
US8882758B2 (en) | 2009-01-09 | 2014-11-11 | Solta Medical, Inc. | Tissue treatment apparatus and systems with pain mitigation and methods for mitigating pain during tissue treatments |
US8372130B2 (en) | 2009-01-23 | 2013-02-12 | Forever Young International, Inc. | Temperature controlled facial mask with area-specific treatments |
CA2751527C (en) | 2009-02-20 | 2020-05-05 | Niveus Medical, Inc. | Systems and methods of powered muscle stimulation using an energy guidance field |
US20110313412A1 (en) | 2009-02-23 | 2011-12-22 | Miramar Labs, Inc. | Tissue interface system and method |
US8939914B2 (en) | 2009-02-27 | 2015-01-27 | Thermimage, Inc. | Radiometers and related devices and methods |
US8298225B2 (en) | 2009-03-19 | 2012-10-30 | Tyco Healthcare Group Lp | System and method for return electrode monitoring |
DE102009014976B3 (en) | 2009-03-30 | 2010-06-02 | Jutta Munz | Applicator device for applying e.g. cream on eye portion of human body, has activator device provided in upper housing part, and producing heat or coldness that is transmitted to substance contained in substance chamber |
ES2916830T3 (en) | 2009-04-30 | 2022-07-06 | Zeltiq Aesthetics Inc | Device for removing heat from lipid-rich subcutaneous cells |
US9545284B2 (en) | 2009-04-30 | 2017-01-17 | Alma Lasers Ltd. | Devices and methods for dermatological treatment |
FR2946845B1 (en) | 2009-06-18 | 2011-08-19 | Oreal | DEVICE FOR TREATING HUMAN KERATINIC MATERIALS |
US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
US8523791B2 (en) | 2009-08-11 | 2013-09-03 | Laboratoire Naturel Paris, Llc | Multi-modal drug delivery system |
US20110040361A1 (en) | 2009-08-12 | 2011-02-17 | Elizabeth Joyce Levy | Cosmetic and Dermatological Cryotherapy Device |
US7946986B2 (en) | 2009-09-29 | 2011-05-24 | Medicis Technologies Corporation | Cartridge for use with an ultrasound therapy head |
US20110112520A1 (en) | 2009-11-11 | 2011-05-12 | Invasix Corporation | Method and device for fat treatment |
WO2011091293A1 (en) | 2010-01-21 | 2011-07-28 | Zeltiq Aesthetics, Inc. | Compositions for use with a system for improved cooling of subcutaneous lipid-rich tissue |
AU2011207492A1 (en) | 2010-01-25 | 2012-08-16 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US9314368B2 (en) | 2010-01-25 | 2016-04-19 | Zeltiq Aesthetics, Inc. | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods |
DE102010007177B4 (en) | 2010-02-08 | 2017-06-22 | Siemens Healthcare Gmbh | Display method for an image of the interior of a vessel located in front of a widening device and display device corresponding thereto |
US20110196438A1 (en) | 2010-02-10 | 2011-08-11 | Lukas Mnozil | Therapy device and method for treating underlying tissue using electrical and acoustic energies |
US20110202048A1 (en) | 2010-02-12 | 2011-08-18 | Solta Medical, Inc. | Methods for pain reduction with functional thermal stimulation and tissue treatment systems |
US9980765B2 (en) | 2010-02-15 | 2018-05-29 | The General Hospital Corporation | Methods and devices for selective disruption of visceral fat by controlled cooling |
US20120089211A1 (en) * | 2010-04-08 | 2012-04-12 | Myoscience, Inc. | Methods and apparatus for cryogenically treating multiple tissue sites with a single puncture |
US20110257642A1 (en) | 2010-04-16 | 2011-10-20 | Griggs Iii Charles Sherman | Method for producing a permanent or nearly permanent skin image, design or tattoo by freezing the skin |
WO2011163264A2 (en) | 2010-06-21 | 2011-12-29 | Candela Corporation | Driving microneedle arrays into skin and delivering rf energy |
US8676338B2 (en) | 2010-07-20 | 2014-03-18 | Zeltiq Aesthetics, Inc. | Combined modality treatment systems, methods and apparatus for body contouring applications |
FR2967893B1 (en) | 2010-11-25 | 2013-10-18 | Zadeh David Khorassani | MASSAGE APPARATUS COMPRISING A SUCTION SYSTEM |
NZ596830A (en) | 2010-12-01 | 2013-06-28 | Gold Rythmn Pty Ltd | Cryogenic freezing of skin folds or wrinkles on merino sheep to tighten or contract the skin to reduce flystrike and infestation |
US20130019374A1 (en) | 2011-01-04 | 2013-01-24 | Schwartz Alan N | Gel-based seals and fixation devices and associated systems and methods |
US10722395B2 (en) | 2011-01-25 | 2020-07-28 | Zeltiq Aesthetics, Inc. | Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells |
KR101993810B1 (en) | 2011-01-28 | 2019-06-27 | 더 제너럴 하스피탈 코포레이션 | An apparatus for cosmetic resurfacing of a skin tissue |
US20120209363A1 (en) | 2011-02-10 | 2012-08-16 | R2T2 Solutions Llc | Hot and cold therapy device |
US9021614B2 (en) | 2011-02-18 | 2015-05-05 | Medical Techology, Inc. | Leg protector for sports activities |
EP2686651B1 (en) | 2011-03-18 | 2017-05-03 | Augustine Biomedical and Design, LLC | Non-invasive core temperature sensor |
US9038640B2 (en) | 2011-03-31 | 2015-05-26 | Viora Ltd. | System and method for fractional treatment of skin |
US20120310232A1 (en) | 2011-06-06 | 2012-12-06 | Danny Erez | System and method for treating a tissue using multiple energy types |
RU2491337C2 (en) * | 2011-06-09 | 2013-08-27 | Елена Владимировна Орлова | Preparation and method of cultivation, storage and cryoconservation of stem and differentiated human and animal cells |
WO2013013059A1 (en) | 2011-07-20 | 2013-01-24 | Scr Inc. | Athletic cooling and heating systems, devices and methods |
US9314301B2 (en) | 2011-08-01 | 2016-04-19 | Miramar Labs, Inc. | Applicator and tissue interface module for dermatological device |
ES2562990T3 (en) | 2011-09-05 | 2016-03-09 | Venus Concept Ltd | Improved aesthetic device to beautify the skin |
US20130073017A1 (en) | 2011-09-15 | 2013-03-21 | Fong Yu Liu | Thermal vacuum therapy and apparatus thereof |
WO2013052634A1 (en) | 2011-10-04 | 2013-04-11 | Bioheat Transfer, Llc | Improved cryotherapy devices and methods to limit ischemic injury side effects |
KR20130043299A (en) | 2011-10-20 | 2013-04-30 | 김기태 | Medical skin beauty care apparatus for heating and stimulating skin using thermoelectric module and ultra-sonic vibrator |
KR102051079B1 (en) | 2011-11-16 | 2019-12-02 | 더 제너럴 하스피탈 코포레이션 | Method and apparatus for cryogenic treatment of skin tissue |
EP2606845B1 (en) | 2011-12-23 | 2016-10-26 | Lina Medical ApS | Pulse generator |
WO2013107504A1 (en) | 2012-01-17 | 2013-07-25 | Telefonaktiebolaget L M Ericsson (Publ) | Ice based nat traversal |
US8397518B1 (en) | 2012-02-20 | 2013-03-19 | Dhama Innovations PVT. Ltd. | Apparel with integral heating and cooling device |
US20130315999A1 (en) * | 2012-04-20 | 2013-11-28 | The General Hospital Corporation | Compositions and methods comprising energy absorbing compoundfs for follicular delivery |
US20130331914A1 (en) | 2012-06-11 | 2013-12-12 | Martin Lee | Thermal therapy system and method of use |
USD702848S1 (en) | 2012-06-18 | 2014-04-15 | Myoscience, Inc. | Handheld device |
WO2013190336A2 (en) | 2012-06-22 | 2013-12-27 | Physiolab Technologies Limited | Thermal and/or pressure regulation control system |
KR20140038165A (en) | 2012-09-20 | 2014-03-28 | (주)휴톤 | Multi function apparatus for treating skin |
RU2519637C1 (en) * | 2012-12-20 | 2014-06-20 | Федеральное государственное бюджетное учреждение "Медицинский радиологический научный центр" Министерства здравоохранения Российской Федерации (ФГБУ МРНЦ Минздрава России) | Method for fertility recovery in patients with oncological diseases |
US9710607B2 (en) | 2013-01-15 | 2017-07-18 | Itrace Biomedical Inc. | Portable electronic therapy device and the method thereof |
KR20140092121A (en) | 2013-01-15 | 2014-07-23 | 삼성전자주식회사 | Method for cooling ultrasound treatment apparatus, ultrasound treatment apparatus by using the same |
KR101451891B1 (en) | 2013-01-22 | 2014-10-16 | 유니스파테크주식회사 | Decompression skin management device |
US9844460B2 (en) | 2013-03-14 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same |
US9545523B2 (en) | 2013-03-14 | 2017-01-17 | Zeltiq Aesthetics, Inc. | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue |
EP2967633B1 (en) | 2013-03-15 | 2018-04-25 | Edge Systems LLC | Devices for treating the skin |
JP6259908B2 (en) | 2013-05-30 | 2018-01-10 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Non-invasive device for regenerating skin tissue using therapeutic pressure below ambient pressure |
US9681980B2 (en) | 2013-06-07 | 2017-06-20 | Core Thermal, Inc. | Modifying humidity to glabrous tissue for the treatment of migraine and other conditions |
KR101487850B1 (en) | 2013-08-08 | 2015-02-02 | (주)클래시스 | apparatus for treating obesity by freezing fat cell |
TWM476644U (en) | 2013-10-11 | 2014-04-21 | Maxxam Tech Corp | Water purifier structure |
EP3981465A1 (en) | 2013-11-14 | 2022-04-13 | RM2 Technology LLC | Systems and apparatuses for delivery of electrolysis products |
US8764693B1 (en) | 2013-11-20 | 2014-07-01 | Richard A. Graham | Systems and methods for decompression and elliptical traction of the cervical and thoracic spine |
RU2585787C2 (en) | 2013-12-09 | 2016-06-10 | Общество с ограниченной ответственностью "Умные адгезивы" | Hydrophilic thermally switched pressure-sensitive adhesive composition reversibly coming off in water at elevated temperatures |
CA2936235A1 (en) | 2014-01-10 | 2015-07-16 | Marcio Marc Abreu | Devices to monitor and provide treatment at an abreu brain tunnel |
US10575890B2 (en) | 2014-01-31 | 2020-03-03 | Zeltiq Aesthetics, Inc. | Treatment systems and methods for affecting glands and other targeted structures |
WO2015117005A1 (en) | 2014-01-31 | 2015-08-06 | The General Hospital Corporation | Cooling device to disrupt function sebaceous glands |
US10675176B1 (en) | 2014-03-19 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Treatment systems, devices, and methods for cooling targeted tissue |
USD777338S1 (en) | 2014-03-20 | 2017-01-24 | Zeltiq Aesthetics, Inc. | Cryotherapy applicator for cooling tissue |
US10952891B1 (en) | 2014-05-13 | 2021-03-23 | Zeltiq Aesthetics, Inc. | Treatment systems with adjustable gap applicators and methods for cooling tissue |
CN104127279B (en) | 2014-08-06 | 2019-03-15 | 珠海横琴早晨科技有限公司 | A kind of film of multi-functional spontaneous adjusting temperature and its application |
WO2016028798A1 (en) | 2014-08-18 | 2016-02-25 | Miramar Labs, Inc. | Apparatus, system and method for treating fat tissue |
US10568759B2 (en) | 2014-08-19 | 2020-02-25 | Zeltiq Aesthetics, Inc. | Treatment systems, small volume applicators, and methods for treating submental tissue |
US10935174B2 (en) | 2014-08-19 | 2021-03-02 | Zeltiq Aesthetics, Inc. | Stress relief couplings for cryotherapy apparatuses |
US9752856B2 (en) | 2014-08-21 | 2017-09-05 | Michael Blake Rashad | Protective collapsible shield |
US20160089550A1 (en) | 2014-09-25 | 2016-03-31 | Zeltiq Aesthetics, Inc. | Treatment systems, methods, and apparatuses for altering the appearance of skin |
JP6923443B2 (en) | 2014-10-15 | 2021-08-18 | ブレインクール アーベー | Devices and methods for lowering a patient's core body temperature for hypothermia treatment by cooling at least two body parts of the patient |
US20160317346A1 (en) | 2015-04-28 | 2016-11-03 | Zeltiq Aesthetics, Inc. | Systems and methods for monitoring cooling of skin and tissue to identify freeze events |
WO2017041022A1 (en) | 2015-09-04 | 2017-03-09 | R2 Dermatology, Inc. | Medical systems, methods, and devices for hypopigmentation cooling treatments |
EP3352716A1 (en) | 2015-09-21 | 2018-08-01 | Zeltiq Aesthetics, Inc. | Transcutaneous treatment systems and cooling devices |
WO2017070112A1 (en) | 2015-10-19 | 2017-04-27 | Zeltiq Aesthetics, Inc. | Vascular treatment systems, cooling devices, and methods for cooling vascular structures |
CA3009414A1 (en) | 2016-01-07 | 2017-07-13 | Zeltiq Aesthetics, Inc. | Temperature-dependent adhesion between applicator and skin during cooling of tissue |
US10765552B2 (en) | 2016-02-18 | 2020-09-08 | Zeltiq Aesthetics, Inc. | Cooling cup applicators with contoured heads and liner assemblies |
US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
US10555831B2 (en) | 2016-05-10 | 2020-02-11 | Zeltiq Aesthetics, Inc. | Hydrogel substances and methods of cryotherapy |
US20170326346A1 (en) | 2016-05-10 | 2017-11-16 | Zeltiq Aesthetics, Inc. | Permeation enhancers and methods of cryotherapy |
US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
US20180263677A1 (en) | 2017-03-16 | 2018-09-20 | Zeltiq Aesthetics, Inc. | Adhesive liners for cryotherapy |
US20180271767A1 (en) | 2017-03-21 | 2018-09-27 | Zeltiq Aesthetics, Inc. | Use of saccharides for cryoprotection and related technology |
US11076879B2 (en) | 2017-04-26 | 2021-08-03 | Zeltiq Aesthetics, Inc. | Shallow surface cryotherapy applicators and related technology |
GB2565139A (en) | 2017-08-04 | 2019-02-06 | R N Ventures | Cryotherapy device |
WO2020028472A1 (en) | 2018-07-31 | 2020-02-06 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
US20200069458A1 (en) | 2018-08-31 | 2020-03-05 | Zeltiq Aesthetics, Inc. | Compositions, treatment systems, and methods for fractionally freezing tissue |
USD921911S1 (en) | 2019-06-21 | 2021-06-08 | Recensmedical, Inc. | Medical cooling device |
USD921211S1 (en) | 2019-06-21 | 2021-06-01 | Recensmedical, Inc. | Medical cooling device |
CA3188869A1 (en) | 2020-08-14 | 2022-02-17 | Mark William Baker | Multi-applicator system and method for body contouring |
-
2015
- 2015-01-30 US US15/115,503 patent/US10575890B2/en active Active
- 2015-01-30 EP EP15704438.9A patent/EP3099260A2/en not_active Withdrawn
- 2015-01-30 EP EP15704437.1A patent/EP3099259A1/en not_active Withdrawn
- 2015-01-30 WO PCT/US2015/013971 patent/WO2015117032A1/en active Application Filing
- 2015-01-30 EP EP15704186.4A patent/EP3099258B1/en active Active
- 2015-01-30 EP EP15704663.2A patent/EP3099261A2/en not_active Withdrawn
- 2015-01-30 WO PCT/US2015/013912 patent/WO2015117001A1/en active Application Filing
- 2015-01-30 WO PCT/US2015/013959 patent/WO2015117026A2/en active Application Filing
- 2015-01-30 US US14/611,127 patent/US10201380B2/en active Active
- 2015-01-30 US US14/610,807 patent/US9861421B2/en active Active
- 2015-01-30 WO PCT/US2015/013985 patent/WO2015117036A2/en active Application Filing
- 2015-01-30 US US14/611,052 patent/US20150216719A1/en not_active Abandoned
- 2015-01-30 EP EP23186988.4A patent/EP4279041A3/en active Pending
-
2017
- 2017-12-06 US US15/833,329 patent/US10912599B2/en active Active
-
2018
- 2018-12-20 US US16/227,376 patent/US20190142493A1/en not_active Abandoned
- 2018-12-27 US US16/233,951 patent/US10806500B2/en active Active
-
2020
- 2020-01-07 US US16/736,672 patent/US20200138501A1/en not_active Abandoned
- 2020-10-15 US US17/072,020 patent/US20210038278A1/en not_active Abandoned
-
2021
- 2021-01-07 US US17/143,163 patent/US11819257B2/en active Active
-
2022
- 2022-04-13 US US17/719,661 patent/US20220387091A1/en not_active Abandoned
-
2023
- 2023-05-04 US US18/143,555 patent/US20240000492A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070255362A1 (en) * | 2006-04-28 | 2007-11-01 | Juniper Medical, Inc. | Cryoprotectant for use with a cooling device for improved cooling of subcutaneous lipid-rich cells |
US20160135985A1 (en) * | 2008-08-07 | 2016-05-19 | The General Hospital Corporation | Method and apparatus for dermatological hypopigmentation |
US20140303697A1 (en) * | 2011-11-16 | 2014-10-09 | The General Hospital Corporation | Method and apparatus for cryogenic treatment of skin tissue |
US20150223975A1 (en) * | 2014-02-12 | 2015-08-13 | The General Hospital Corporation | Method and apparatus for affecting pigmentation of tissue |
Cited By (135)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11395760B2 (en) | 2006-09-26 | 2022-07-26 | Zeltiq Aesthetics, Inc. | Tissue treatment methods |
US11179269B2 (en) | 2006-09-26 | 2021-11-23 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
US10292859B2 (en) | 2006-09-26 | 2019-05-21 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
US11219549B2 (en) | 2006-09-26 | 2022-01-11 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
US11291606B2 (en) | 2007-05-18 | 2022-04-05 | Zeltiq Aesthetics, Inc. | Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue |
US10383787B2 (en) | 2007-05-18 | 2019-08-20 | Zeltiq Aesthetics, Inc. | Treatment apparatus for removing heat from subcutaneous lipid-rich cells and massaging tissue |
US9655770B2 (en) | 2007-07-13 | 2017-05-23 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
US11583438B1 (en) | 2007-08-21 | 2023-02-21 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
US9408745B2 (en) | 2007-08-21 | 2016-08-09 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
US10675178B2 (en) | 2007-08-21 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
US9737434B2 (en) | 2008-12-17 | 2017-08-22 | Zeltiq Aestehtics, Inc. | Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells |
US11452634B2 (en) | 2009-04-30 | 2022-09-27 | Zeltiq Aesthetics, Inc. | Device, system and method of removing heat from subcutaneous lipid-rich cells |
US11224536B2 (en) | 2009-04-30 | 2022-01-18 | Zeltiq Aesthetics, Inc. | Device, system and method of removing heat from subcutaneous lipid-rich cells |
US9861520B2 (en) | 2009-04-30 | 2018-01-09 | Zeltiq Aesthetics, Inc. | Device, system and method of removing heat from subcutaneous lipid-rich cells |
US9314368B2 (en) | 2010-01-25 | 2016-04-19 | Zeltiq Aesthetics, Inc. | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods |
US10092346B2 (en) | 2010-07-20 | 2018-10-09 | Zeltiq Aesthetics, Inc. | Combined modality treatment systems, methods and apparatus for body contouring applications |
US10722395B2 (en) | 2011-01-25 | 2020-07-28 | Zeltiq Aesthetics, Inc. | Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells |
US11612758B2 (en) | 2012-07-05 | 2023-03-28 | Btl Medical Solutions A.S. | Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields |
US10765880B2 (en) | 2012-07-05 | 2020-09-08 | Btl Medical Technologies S.R.O. | Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields |
US10806943B2 (en) | 2012-07-05 | 2020-10-20 | Btl Medical Technologies S.R.O. | Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields |
US9844460B2 (en) | 2013-03-14 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same |
US9545523B2 (en) | 2013-03-14 | 2017-01-17 | Zeltiq Aesthetics, Inc. | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue |
US9861421B2 (en) | 2014-01-31 | 2018-01-09 | Zeltiq Aesthetics, Inc. | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US10575890B2 (en) * | 2014-01-31 | 2020-03-03 | Zeltiq Aesthetics, Inc. | Treatment systems and methods for affecting glands and other targeted structures |
US20210038278A1 (en) * | 2014-01-31 | 2021-02-11 | Zeltiq Aesthetics, Inc. | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US10912599B2 (en) | 2014-01-31 | 2021-02-09 | Zeltiq Aesthetics, Inc. | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US20150216720A1 (en) * | 2014-01-31 | 2015-08-06 | Zeltiq Aesthetics, Inc. | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US11819257B2 (en) | 2014-01-31 | 2023-11-21 | Zeltiq Aesthetics, Inc. | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US10201380B2 (en) * | 2014-01-31 | 2019-02-12 | Zeltiq Aesthetics, Inc. | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US20200138501A1 (en) * | 2014-01-31 | 2020-05-07 | Zeltiq Aesthestics, Inc. | Treatment systems and methods for affecting glands and other targeted structures |
US10806500B2 (en) | 2014-01-31 | 2020-10-20 | Zeltiq Aesthetics, Inc. | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments |
US20170007309A1 (en) * | 2014-01-31 | 2017-01-12 | Zeltiq Aesthestics, Inc. | Treatment systems and methods for affecting glands and other targeted structures |
US10675176B1 (en) | 2014-03-19 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Treatment systems, devices, and methods for cooling targeted tissue |
USD777338S1 (en) | 2014-03-20 | 2017-01-24 | Zeltiq Aesthetics, Inc. | Cryotherapy applicator for cooling tissue |
US10952891B1 (en) | 2014-05-13 | 2021-03-23 | Zeltiq Aesthetics, Inc. | Treatment systems with adjustable gap applicators and methods for cooling tissue |
US10568759B2 (en) | 2014-08-19 | 2020-02-25 | Zeltiq Aesthetics, Inc. | Treatment systems, small volume applicators, and methods for treating submental tissue |
US10935174B2 (en) | 2014-08-19 | 2021-03-02 | Zeltiq Aesthetics, Inc. | Stress relief couplings for cryotherapy apparatuses |
US11534335B2 (en) | 2014-10-01 | 2022-12-27 | Cryosa, Inc. | Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues |
US10124187B2 (en) * | 2015-04-28 | 2018-11-13 | Btl Holdings Limited | Combination of radiofrequency and magnetic treatment methods |
US20160317827A1 (en) * | 2015-04-28 | 2016-11-03 | Btl Holdings Limited | Combination of radiofrequency and magnetic treatment methods |
US11957635B2 (en) | 2015-06-20 | 2024-04-16 | Therabody, Inc. | Percussive therapy device with variable amplitude |
US10569094B2 (en) | 2015-07-01 | 2020-02-25 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US11266850B2 (en) | 2015-07-01 | 2022-03-08 | Btl Healthcare Technologies A.S. | High power time varying magnetic field therapy |
US10549110B1 (en) | 2015-07-01 | 2020-02-04 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10821295B1 (en) | 2015-07-01 | 2020-11-03 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10245439B1 (en) | 2015-07-01 | 2019-04-02 | Medical Technologies Cz A.S. | Aesthetic method of biological structure treatment by magnetic field |
US11253718B2 (en) | 2015-07-01 | 2022-02-22 | Btl Healthcare Technologies A.S. | High power time varying magnetic field therapy |
US10471269B1 (en) | 2015-07-01 | 2019-11-12 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10493293B2 (en) | 2015-07-01 | 2019-12-03 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10569095B1 (en) | 2015-07-01 | 2020-02-25 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10549109B2 (en) | 2015-07-01 | 2020-02-04 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US9974519B1 (en) | 2015-07-01 | 2018-05-22 | Btl Holdings Limited | Aesthetic method of biologoical structure treatment by magnetic field |
US9937358B2 (en) | 2015-07-01 | 2018-04-10 | Btl Holdings Limited | Aesthetic methods of biological structure treatment by magnetic field |
US11491342B2 (en) | 2015-07-01 | 2022-11-08 | Btl Medical Solutions A.S. | Magnetic stimulation methods and devices for therapeutic treatments |
US10695576B2 (en) | 2015-07-01 | 2020-06-30 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10478634B2 (en) | 2015-07-01 | 2019-11-19 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10478633B2 (en) | 2015-07-01 | 2019-11-19 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10688310B2 (en) | 2015-07-01 | 2020-06-23 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10709894B2 (en) | 2015-07-01 | 2020-07-14 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10765467B2 (en) * | 2015-09-04 | 2020-09-08 | R2 Technologies, Inc. | Medical systems, methods, and devices for hypopigmentation cooling treatments |
CN108135644A (en) * | 2015-09-04 | 2018-06-08 | R2皮肤科有限公司 | Medical system, method and apparatus for hypopigmentation cooling treatment |
US20210015536A1 (en) * | 2015-09-04 | 2021-01-21 | R2 Technologies, Inc. | Medical systems, methods, and devices for hypopigmentation cooling treatments |
US20170065323A1 (en) * | 2015-09-04 | 2017-03-09 | R2 Dermatology, Inc. | Medical Systems, Methods, and Devices for Hypopigmentation Cooling Treatments |
US20170079833A1 (en) * | 2015-09-21 | 2017-03-23 | Zeltiq Aesthestics, Inc. | Transcutaneous treatment systems, cooling devices, and methods for cooling nerves |
CN105169574A (en) * | 2015-09-30 | 2015-12-23 | 何燕岳 | Ultrasonic wave coolsculpting device |
WO2017070112A1 (en) | 2015-10-19 | 2017-04-27 | Zeltiq Aesthetics, Inc. | Vascular treatment systems, cooling devices, and methods for cooling vascular structures |
US11154418B2 (en) * | 2015-10-19 | 2021-10-26 | Zeltiq Aesthetics, Inc. | Vascular treatment systems, cooling devices, and methods for cooling vascular structures |
US11253717B2 (en) | 2015-10-29 | 2022-02-22 | Btl Healthcare Technologies A.S. | Aesthetic method of biological structure treatment by magnetic field |
US10524956B2 (en) | 2016-01-07 | 2020-01-07 | Zeltiq Aesthetics, Inc. | Temperature-dependent adhesion between applicator and skin during cooling of tissue |
US10765552B2 (en) | 2016-02-18 | 2020-09-08 | Zeltiq Aesthetics, Inc. | Cooling cup applicators with contoured heads and liner assemblies |
US11883643B2 (en) | 2016-05-03 | 2024-01-30 | Btl Healthcare Technologies A.S. | Systems and methods for treatment of a patient including RF and electrical energy |
US11602629B2 (en) | 2016-05-03 | 2023-03-14 | Btl Healthcare Technologies A.S. | Systems and methods for treatment of a patient including rf and electrical energy |
US11464993B2 (en) | 2016-05-03 | 2022-10-11 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US11247039B2 (en) | 2016-05-03 | 2022-02-15 | Btl Healthcare Technologies A.S. | Device including RF source of energy and vacuum system |
US11590356B2 (en) | 2016-05-10 | 2023-02-28 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US10555831B2 (en) | 2016-05-10 | 2020-02-11 | Zeltiq Aesthetics, Inc. | Hydrogel substances and methods of cryotherapy |
US10709895B2 (en) | 2016-05-10 | 2020-07-14 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US11464994B2 (en) | 2016-05-10 | 2022-10-11 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
JP2019514616A (en) * | 2016-05-10 | 2019-06-06 | ゼルティック エステティックス インコーポレイテッド | Skin freezing system for treating acne and skin conditions |
US11534619B2 (en) | 2016-05-10 | 2022-12-27 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
WO2017196548A1 (en) | 2016-05-10 | 2017-11-16 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
US10695575B1 (en) | 2016-05-10 | 2020-06-30 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
US11691024B2 (en) | 2016-05-10 | 2023-07-04 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
CN109310516A (en) * | 2016-05-10 | 2019-02-05 | 斯尔替克美学股份有限公司 | For handling the skin freezing system of acne and skin |
US11878162B2 (en) | 2016-05-23 | 2024-01-23 | Btl Healthcare Technologies A.S. | Systems and methods for tissue treatment |
US11623083B2 (en) | 2016-05-23 | 2023-04-11 | Btl Healthcare Technologies A.S. | Systems and methods for tissue treatment |
US11896821B2 (en) | 2016-05-23 | 2024-02-13 | Btl Healthcare Technologies A.S. | Systems and methods for tissue treatment |
US11458307B2 (en) | 2016-05-23 | 2022-10-04 | Btl Healthcare Technologies A.S. | Systems and methods for tissue treatment |
US11185690B2 (en) | 2016-05-23 | 2021-11-30 | BTL Healthcare Technologies, a.s. | Systems and methods for tissue treatment |
US11266524B2 (en) | 2016-06-03 | 2022-03-08 | R2 Technologies, Inc. | Medical methods and systems for skin treatment |
CN109310460A (en) * | 2016-06-03 | 2019-02-05 | R2皮肤科有限公司 | Cooling system and skin processing method |
KR20190015727A (en) * | 2016-06-03 | 2019-02-14 | 알2 더마톨로지, 인크. | Cooling system and method for skin treatment |
EP3463132A4 (en) * | 2016-06-03 | 2020-01-22 | R2 Dermatology, Inc. | Cooling systems and methods for skin treatment |
KR102448859B1 (en) | 2016-06-03 | 2022-10-04 | 알2 테크놀로지스, 인크. | Cooling systems and methods for skin treatment |
US11679270B2 (en) | 2016-07-01 | 2023-06-20 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US11607556B2 (en) | 2016-07-01 | 2023-03-21 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US11794029B2 (en) | 2016-07-01 | 2023-10-24 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US11266852B2 (en) | 2016-07-01 | 2022-03-08 | Btl Healthcare Technologies A.S. | Aesthetic method of biological structure treatment by magnetic field |
US10556122B1 (en) | 2016-07-01 | 2020-02-11 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US11628308B2 (en) | 2016-07-01 | 2023-04-18 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US11484727B2 (en) | 2016-07-01 | 2022-11-01 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US10632321B2 (en) | 2016-07-01 | 2020-04-28 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US10596386B2 (en) | 2016-07-01 | 2020-03-24 | Btl Medical Technologies S.R.O. | Aesthetic method of biological structure treatment by magnetic field |
US20180001106A1 (en) | 2016-07-01 | 2018-01-04 | Btl Holdings Limited | Aesthetic method of biological structure treatment by magnetic field |
US11497925B2 (en) | 2016-07-01 | 2022-11-15 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
US11524171B2 (en) | 2016-07-01 | 2022-12-13 | Btl Medical Solutions A.S. | Aesthetic method of biological structure treatment by magnetic field |
WO2018111068A1 (en) * | 2016-12-15 | 2018-06-21 | Castro Baldenebro Brayan Gamaniel | System for treating skin lesions caused by acne by means of thermal shocks |
WO2018111069A1 (en) * | 2016-12-15 | 2018-06-21 | Castro Baldenebro Brayan Gamaniel | Method for identifying skin lesions caused by acne by means of multispectral-image capture with prior cooling |
WO2018175111A1 (en) | 2017-03-21 | 2018-09-27 | Zeltiq Aesthetics, Inc. | Use of saccharides for cryoprotection and related technology |
US11076879B2 (en) | 2017-04-26 | 2021-08-03 | Zeltiq Aesthetics, Inc. | Shallow surface cryotherapy applicators and related technology |
WO2020023406A1 (en) * | 2018-07-23 | 2020-01-30 | Nc8, Inc. | Cellulite treatment system and methods |
WO2020023412A1 (en) * | 2018-07-23 | 2020-01-30 | Nc8, Inc. | Cellulite treatment system and methods |
US11446175B2 (en) * | 2018-07-31 | 2022-09-20 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
WO2020028472A1 (en) * | 2018-07-31 | 2020-02-06 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
US20230051638A1 (en) * | 2018-07-31 | 2023-02-16 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
CN112789013A (en) * | 2018-07-31 | 2021-05-11 | 斯尔替克美学股份有限公司 | Method, device and system for improving skin |
US11357697B2 (en) * | 2018-12-26 | 2022-06-14 | Therabody, Inc. | Percussive therapy device |
US11564860B2 (en) | 2018-12-26 | 2023-01-31 | Therabody, Inc. | Percussive therapy device with electrically connected attachment |
US11452670B2 (en) | 2018-12-26 | 2022-09-27 | Therabody, Inc. | Percussive therapy device with orientation, position, and force sensing and accessory therefor |
US11890253B2 (en) * | 2018-12-26 | 2024-02-06 | Therabody, Inc. | Percussive therapy device with interchangeable modules |
US20220257460A1 (en) * | 2018-12-26 | 2022-08-18 | Therabody, Inc. | Percussive therapy device with interchangeable modules |
WO2020161452A1 (en) * | 2019-02-06 | 2020-08-13 | Bb Brands Ltd | Cryotherapy device |
US11484725B2 (en) | 2019-04-11 | 2022-11-01 | Btl Medical Solutions A.S. | Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy |
US11247063B2 (en) | 2019-04-11 | 2022-02-15 | Btl Healthcare Technologies A.S. | Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy |
US11813221B2 (en) | 2019-05-07 | 2023-11-14 | Therabody, Inc. | Portable percussive massage device |
US11826565B2 (en) | 2020-05-04 | 2023-11-28 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US11878167B2 (en) | 2020-05-04 | 2024-01-23 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US11813451B2 (en) | 2020-05-04 | 2023-11-14 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US11806528B2 (en) | 2020-05-04 | 2023-11-07 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
EP4082460A1 (en) * | 2021-04-28 | 2022-11-02 | High Technology Products, S.L.U. | Methods and systems for determining freezing of skin during cooling |
WO2022229277A1 (en) * | 2021-04-28 | 2022-11-03 | High Technology Products, S.l.u. | Methods and systems for determining freezing of skin during cooling |
US11896816B2 (en) | 2021-11-03 | 2024-02-13 | Btl Healthcare Technologies A.S. | Device and method for unattended treatment of a patient |
US11857481B2 (en) | 2022-02-28 | 2024-01-02 | Therabody, Inc. | System for electrical connection of massage attachment to percussive therapy device |
Also Published As
Publication number | Publication date |
---|---|
WO2015117026A3 (en) | 2015-10-15 |
EP3099259A1 (en) | 2016-12-07 |
US20200138501A1 (en) | 2020-05-07 |
EP3099258B1 (en) | 2024-02-21 |
US20220387091A1 (en) | 2022-12-08 |
US10201380B2 (en) | 2019-02-12 |
US20240000492A1 (en) | 2024-01-04 |
EP3099260A2 (en) | 2016-12-07 |
EP4279041A2 (en) | 2023-11-22 |
US20210282829A1 (en) | 2021-09-16 |
US9861421B2 (en) | 2018-01-09 |
US20150216816A1 (en) | 2015-08-06 |
WO2015117032A8 (en) | 2016-09-22 |
WO2015117026A2 (en) | 2015-08-06 |
US20190125424A1 (en) | 2019-05-02 |
WO2015117032A1 (en) | 2015-08-06 |
US20170007309A1 (en) | 2017-01-12 |
US20190142493A1 (en) | 2019-05-16 |
WO2015117001A1 (en) | 2015-08-06 |
EP3099258A1 (en) | 2016-12-07 |
WO2015117036A2 (en) | 2015-08-06 |
US11819257B2 (en) | 2023-11-21 |
EP4279041A3 (en) | 2024-01-24 |
EP3099261A2 (en) | 2016-12-07 |
WO2015117026A8 (en) | 2015-12-03 |
US20150216720A1 (en) | 2015-08-06 |
US10806500B2 (en) | 2020-10-20 |
US20210038278A1 (en) | 2021-02-11 |
US10575890B2 (en) | 2020-03-03 |
US20180185081A1 (en) | 2018-07-05 |
US10912599B2 (en) | 2021-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20220387091A1 (en) | Treatment systems and methods for treating cellulite and for providing other treatments | |
US20230041283A1 (en) | Skin freezing systems for treating acne and skin conditions | |
US20230021151A1 (en) | Liposomes, emulsions, and methods for cryotherapy | |
US9545523B2 (en) | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue | |
US10555831B2 (en) | Hydrogel substances and methods of cryotherapy | |
US10092346B2 (en) | Combined modality treatment systems, methods and apparatus for body contouring applications | |
US20170326346A1 (en) | Permeation enhancers and methods of cryotherapy | |
US20200069458A1 (en) | Compositions, treatment systems, and methods for fractionally freezing tissue |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: ZELTIQ AESTHETICS, INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:TATSUTANI, KRISTINE;REEL/FRAME:041584/0044 Effective date: 20170302 |
|
AS | Assignment |
Owner name: ZELTIQ AESTHETICS, INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DEBENEDICTIS, LEONARD C.;FRANGINEAS, GEORGE, JR.;PHAM, LINDA;SIGNING DATES FROM 20150304 TO 20150311;REEL/FRAME:041642/0339 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: ADVISORY ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: FINAL REJECTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE AFTER FINAL ACTION FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: ADVISORY ACTION MAILED |
|
STCV | Information on status: appeal procedure |
Free format text: NOTICE OF APPEAL FILED |
|
STCV | Information on status: appeal procedure |
Free format text: APPEAL BRIEF (OR SUPPLEMENTAL BRIEF) ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |