US20170079673A1 - Device for positioning an ultrasound transducer inside a mr scanner - Google Patents
Device for positioning an ultrasound transducer inside a mr scanner Download PDFInfo
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- US20170079673A1 US20170079673A1 US15/367,508 US201615367508A US2017079673A1 US 20170079673 A1 US20170079673 A1 US 20170079673A1 US 201615367508 A US201615367508 A US 201615367508A US 2017079673 A1 US2017079673 A1 US 2017079673A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
- A61B17/2255—Means for positioning patient, shock wave apparatus or locating means, e.g. mechanical aspects, patient beds, support arms, aiming means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A61B5/0555—
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4416—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
- A61N7/022—Localised ultrasound hyperthermia intracavitary
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00115—Electrical control of surgical instruments with audible or visual output
- A61B2017/00128—Electrical control of surgical instruments with audible or visual output related to intensity or progress of surgical action
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
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- A61B2017/00199—Electrical control of surgical instruments with a console, e.g. a control panel with a display
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- A61B2017/00831—Material properties
- A61B2017/00902—Material properties transparent or translucent
- A61B2017/00911—Material properties transparent or translucent for fields applied by a magnetic resonance imaging system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2051—Electromagnetic tracking systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/374—NMR or MRI
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B34/70—Manipulators specially adapted for use in surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
Abstract
Description
- This application is a continuation of U.S. application Ser. No. 12/296,769 filed Oct. 10, 2008, now U.S. Pat. No. ______, which is a US National Stage Entry of PCT/US2007/064184 filed Mar. 16, 2007, which claims the benefit of U.S. Provisional Application Ser. No. 60/744,605 filed Apr. 11, 2006.
- The following relates to medical imaging systems. It finds particular application to facilitating the positioning of an ultrasound transducer inside a Magnetic Resonance (MR) scanner, but is also applicable to other medical imaging modalities.
- High intensity focused ultrasound (HIFU) is used to treat tumors, especially uterine fibroids. The treatment is based on warming tissue in and/or near the focus of the ultrasound beam. Sufficient warming causes cell death and subsequently a lesion in the treated volume, which often includes the tumor and some margin of healthy tissue immediately adjacent. The body then slowly absorbs the lesion, leaving the treated area tumor-free.
- To achieve the foregoing, the ultrasound transducer needs to be able to be moved in a manner that focuses the beam at a desired location on the subject while avoiding exposing organs. For suitable movement, at least two translational and two angular degrees of freedom are needed. Controlling the location and extent of the warming can be facilitated via feedback from a device that can visualize both the anatomy of the treatment area and the temperature profile generated. A MR scanner can perform both functions by running dedicated sequences.
- The temperature profile is obtained by locally measuring the magnetic resonance frequency of the protons in the subject. The frequency has a temperature factor that is relatively small being only one millionth of one percent per degree Celsius. The mechanisms for moving the transducer therefore are made of materials that are non-magnetic. Small amounts of any metal can be used, however, plastics and/or ceramics are mainly used. In addition the motors for powering the movements typically are placed about one meter away or more. At the same time the precision of the system is about 0.5 mm or better. This makes the system critical with respect to mechanical slack and bending.
- Conventional treatment systems use positioning devices that focus the high intensity ultrasound on tissue to be treated. The transducer typically is held by a structure shaped similar to a fork that is rotated about a central axis. As a consequence, one side of the transducer is lifted while the other side of the transducer is lowered. This swiveling about the axis when lifting one side of the transducer during focusing creates problems when the transducer is to be placed relatively close to the subject, and such close positioning is often crucial when treating different size patients with tumors located at different depths. In order to make the fork stiff translation in the up-down direction is typically sacrificed, limiting the range of movements.
- In one aspect, a device that positions an ultrasound transducer for ultrasound therapy to focus a treatment beam emitted by the ultrasound transducer at tissue of interest is illustrated. The device includes at least three anchors which support the ultrasound transducer and at least three extendable structures, each with a coupling that supports a corresponding one of the at least three anchors. A drive mechanism independently drives each of the at least three extendable structures towards or away from a subject to move the ultrasound transducer within at least three degrees of freedom.
- One advantage includes facilitating positioning an ultrasound transducer for a high intensity focused ultrasound treatment.
- Another advantage lies in freely translating the ultrasound transducer in all directions and independently inclined around two directions.
- Another advantage includes translating and inclining members with minimum length relative to the amplitudes of the movements, and these members are mechanically stressed only in the lengthwise directions to minimize the amount of transducer displacement caused by elastic deformation in its suspension.
- Another advantage is the translating and inclining members are made using a small amount of material to minimize their influence on the magnetic field inside the subject and on a temperature measurement.
- Another advantage resides in using medical imaging to facilitate focusing the beam of the ultrasound transducer at a region of interest.
- Still further advantages will become apparent to those of ordinary skill in the art upon reading and understanding the detailed description of the preferred embodiments.
- The drawings are only for purposes of illustrating embodiments and are not to be construed as limiting the claims.
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FIG. 1 illustrates a medical treatment system for treating portions of a subject/object with high intensity focused ultrasound (HIFU). -
FIG. 2 illustrates a receptacle used to position an ultrasound transducer in a retracted position away from a subject. -
FIG. 3 illustrates a technique in which the receptacle holding the ultrasound transducer translates to re-focus the HIFU beam. -
FIG. 4 illustrates a technique in which the receptacle holding the ultrasound transducer translates and rotates to re-focus the HIFU beam. -
FIG. 5 illustrates an exemplary device for moving the receptacle holding the ultrasound transducer to suitably focus the HIFU beam. -
FIG. 6 illustrate an exemplary location of the receptacle within the device holding the ultrasound transducer. -
FIG. 7 illustrate an exemplary axial motion mechanism for controlling an axial position of the receptacle holding the ultrasound transducer. -
FIG. 8 illustrate an exemplary longitudinal motion mechanism for controlling a longitudinal position of the receptacle holding the ultrasound transducer. -
FIGS. 9, 10 and 11 illustrate an exemplary arm and wheel mechanism for driving the receptacle towards and away from the subject. -
FIG. 12 illustrates a method for positioning an ultrasound transducer used to treat portions of a subject/object with high intensity focused ultrasound (HIFU). -
FIG. 1 illustrates amedical treatment system 10 for treating a subject/object with high intensity focused ultrasound (HIFU). AHIFU beam 12 is used to treat a region of interest within and/or the subject. The region of interest includes undesired tissue such as a tumor and some margin of healthy tissue. TheHIFU beam 12 is generated and emitted by anultrasound transducer 14, which is suitably positioned to focus thebeam 12 at the region ofinterest 14 by adevice 16 that moves theultrasound transducer 14 through at least five degrees of freedom, at least three degrees of freedom in a direction towards and away from the subject and at least two degrees of freedom in axial and longitudinal directions with respect to the subject. - The
device 16 includes a receptacle orframe 18, which supports theultrasound transducer 14. Thereceptacle 18 hasanchors anchors extendible structures extendible structures 24 are moveably attached to asupport plate 26 and extend and retract from the subject along afirst axis 28. The couplings 22 allow theanchors 20 to translate and/or rotate therein when one or more of theextendible structures 24 extends or retracts. As theanchors 20 translate and/or rotate within their respective couplings 22, thereceptacle 18 translates and/or rotates towards or away from the subject and, hence, thetransducer 14 translates and/or rotates towards or away from the subject. - By way of example,
FIG. 2 illustrates thereceptacle 18 in a retracted position away from the subject. In this example, there are three (i.e., N=3)extendible structures 24, theextendible structure 24 1, theextendible structure 24 2, and anextendible structure 24 3. Theextendible structures 24 are respectively associated with the couplings 22 1, 22 2, and 22 3. In one instance, the couplings 22 are ball joints or the like and theanchors extendible structures 24 are pushrods. As such, the extendible structures 24 (or pushrods) can be mounted to and actuated bylead screws 30 and correspondinglead screw nuts 32 or the like. Thelead screw nuts 32 can be fixed on and rotatible about thefirst axis 28. Driving mechanisms X (described in detail below in connection withFIGS. 9, 10 and 11 ) are used to independently turn each of thelead screw nuts 32, which independently drives eachlead screw 30 andextendible structure 24 along thefirst axis 28. In this example, theanchors 20 are positioned about 60 degrees apart from one another. However, in other embodiments, various other configurations can be used. For instance, in one alternative embodiment two of theanchors 20 are positioned about 180 degrees apart and the third anchor is positioned about 90 degrees apart from the first two anchors. Also, other extendible structures are contemplated, such as air or other fluid cylinders. - In the mode of motion illustrated in
FIG. 3 , the lead screws 30 are simultaneously driven at the same rate towards the subjects, which drives theextendible structures 24 in the same direction (towards the subject) at the same rate. As a result, thereceptacle 18 and theultrasound transducer 14 translate along thefirst axis 28 towards the subject. InFIG. 4 , only thelead screw 30 associated with theextendible structure 24 3 is driven towards the subject. The other lead screws 30 remain in a static position. As a result, theextendible structure 24 3 extends towards the subject, theanchor 20 3 translates through thecoupling 20 3, and theanchor receptacle 18 to rotate or tilt about the couplings 22 1 and 22 2. The rotation of thereceptacle 18 in turn rotates theultrasound transducer 14, which moves the focus point of theHIFU beam 12. - Returning to
FIG. 2 , by independently extending and/or retracting one or more of theextendible structures 24 to similar and/or different distances at similar and/or different rates, up to three degrees of freedom can be achieved and used to effectuate translational, rotational, or both translational and rotational movements of thereceptacle 18 in order to move theultrasound transducer 14 and the focal point of theultrasound beam 12. - Returning to
FIG. 1 , thesupport plate 26 is also attached to afirst end 38 of anaxial motion mechanism 40, which provides translational movement of thesupport plate 26 along a second ortransverse axis 42 in a transverse axial direction (side-to-side) with respect to the subject. Asecond end 44 of theaxial motion mechanism 40 is attached to alongitudinal motion mechanism 46, which provides translational movement of thesupport plate 26 along a third orlongitudinal axis 48 in a longitudinal direction with respect to the subject. The combination of the translational movements along theaxes FIG. 4 ) provides up to five degrees of freedom in which to position thereceptacle 18 to suitably focus theultrasound beam 12. - The
receptacle 18, theanchors 20, the couplings 22, theextendible structures 24, thesupport plate 26, theaxial motion mechanism 40 and thelongitudinal motion mechanism 46 reside within a cavity of a container orshell 50.Controls 52 are used to drive theextendible structures 24, theaxial motion mechanism 40 and thelongitudinal motion mechanism 46 in order to focus theultrasound beam 12. Thecontrols 52 can include mechanical components for manually focusing thebeam 12 and/or electrical components for electrically focusing thebeam 12. - The
device 16 is used in conjunction with ascanning system 54 or other device that is capable of providing information about tissue and/or temperature profiles associated with the treatment area. Such information is used to facilitate positioning thereceptacle 18 to focus theultrasound beam 12. As illustrated inFIG. 1 , thescanning system 54 can be an open Magnetic Resonance (MR) scanner. However, it is to be appreciated that other types of MR scanners and/or other imaging modalities are also contemplated herein. - In this example, the
scanning system 54 includes two main magnets 56 (e.g., permanent or resistive) separated by animaging region 58 in an open configuration. Asupport mechanism 60 is used to position the subject within theimaging region 58. As depicted, thedevice 16 resides within thesupport mechanism 60. The positioning of the twomain magnets 56 is such that the magnets generate a magnetic field (B0) in the subject. Magnetic field gradient coils (not shown, typically housed in or adjacent the main magnets) are arranged to superimpose selected magnetic field gradients on B0. Such gradients include orthogonal magnetic field gradients such as x, y and/or z gradients defined within a Cartesian plane. One or more radio frequency coils (not shown, typically disposed between the gradient coils and the subject) inject radio frequency excitation pulses (B1) into and/or receive resonance signals from theimaging region 58. - A
console 62 and adisplay 64 are used to plan patient procedures (e.g., selecting imaging protocol(s), set imaging parameters, etc.), commence scanning, present reconstructed images, as well as various other features. Theconsole 62 provides instructions to ascanner controller 66 that controls agradient controller 68, a radio frequency (RF)source 70, and areceiver 72. Thegradient controller 68 controls the magnetic field gradient coils to spatially encode the resulting magnetic resonances. TheRF source 70 generates and provides the radio frequency excitation pulses (B1) to the one or more radio frequency coils. During a readout phase, detection circuitry (not shown) detects the magnetic resonance signals, and thereceiver 72 receives the spatially encoded magnetic resonances. The acquired spatially encoded magnetic resonances are stored in astorage component 74 and/or provided to aprocessing component 76, which reconstructs one or more images from the data. Raw and/or processed data (e.g., images) are displayed at thedisplay 64, archived, filmed, conveyed for further processing, etc. - The acquired data and/or resulting images are used to focus the
beam 12 on at the region of interest, which is optionally controlled from theconsole 62 through transducer beam power andcontrol electronics 63 and/or motor power andcontrol electronics 65. For example, the data and/or images provide numerical and/or graphical information about the region of interest such as the images of the treatment tissue and temperature profiles associated therewith. Thus, the data allows the operator to see the area that is being exposed to thebeam 12. The operator can then, if needed, use theconsole 62 to control theelectronics 63 and/or 65 to drive thecontrols 52 to reposition thereceptacle 18 via one or more of the five degrees of freedom described herein to move thetransducer 14 and refine the focus position of thebeam 12. In one embodiment, the ultrasound beam and/or its focal spot are superimposed on the displayed image, e.g. in phantom, with a color change or shift, or the like. This provides the operator with visual feedback as the transducer is positioned. For example, the superimposed images can provide assurance that the focal spot is centered in the target tumor and that no vital or sensitive organs lie in the ultra sound beam. - Now referring to
FIG. 5 , an exemplary configuration of thedevice 16 is illustrated. Thedevice 16 includes thecontainer 50 with acavity 78 in which thereceptacle 18 and associated supporting and moving members are situated. Thecavity 78 is filled with material (e.g., water) that is a substantially non-attenuating to thebeam 12. Thecontainer 50 includes anultrasound transmissive window 80 through which thebeam 12 is directed. Thewindow 80 is illustrated as rectangular in shaped; however, it is to be appreciated that thewindow 80 can be variously shaped. For example, thewindow 80 can alternatively be square, circular, triangular, irregular, etc. in shape. Thecontainer 50 can simply sit within thepatient support 60 and/or be mounted therein through screws, clamps, Velcro™, and the like. InFIG. 6 , thecontainer 50 is illustrated as semi-transparent in order highlight the position of thereceptacle 18 and its associated supporting and moving members within thecontainer 50. -
FIGS. 7 and 8 illustrate exemplary transverse andlongitudinal motion mechanisms FIG. 7 , theaxial motion mechanism 40, which includes arail 82 and acarriage 84, is highlighted. The support 26 (and thus the transducer 14) is coupled to aside 86 of thecarriage 84 and moves with thecarriage 84 along theaxis 42. Therail 82 is mounted at ends 88 and 90 to afirst carriage 92 and asecond carriage 94 of thelongitudinal motion mechanism 46. The first andsecond carriages FIG. 8 . Continuing withFIG. 8 , thefirst carriage 92 is slidably mounted to arail 96, which is mounted thecontainer 50, and thesecond carriage 94 is slidably mounted to arail 98, which is also mounted to thecontainer 50. Both rails 96 and 98 typically are rigidly mounted to thecontainer 50. As discussed above, the first andsecond carriages rail 82, and therail 82 moves with the first andsecond carriages rails axes -
FIGS. 9, 10 and 11 illustrate anexemplary mechanism 100 that can be used to drive theextendible structures 24. As described in connection withFIG. 2 above, eachextendible structure 24 can be extended and/or retracted through a lead screw assembly that includes thelead screw 30 and thelead screw nut 32. Thenut 32 is fixed on and rotatible about thefirst axis 28 at afirst end 102 of afirst arm 104. Asecond end 106 of thefirst arm 104 is coupled to afirst end 108 of asecond arm 110, and asecond end 112 of thesecond arm 110 is attached to acontrol device 114. Gears orwheels ends - As illustrated in
FIGS. 10 and 11 , abelt 124 is used in conjunction with thewheels belt 126 is used in conjunction with thewheels belts wheel 116 translates to a corresponding rotation of the wheel 120 (and vice versa) and rotation of thewheel 118 translates to a corresponding rotation of the wheel 122 (and vice versa). Thebelts - Returning to
FIG. 9 , the first andsecond arms similar axis 128. With this configuration, movement of thesupport 26, and, hence, theultrasound transducer 14, along one or both theaxes control device 114 turns thewheel 122, which turns thebelt 124 ofarm 110, which in turn causes thewheel 120 to rotate. Thewheels wheel 118 turns thebelt 126 ofarm 104, which in turn causes thewheel 116 to rotate. The rotation of thewheel 116 turns thelead screw nut 32, which drives thelead screw 30 andextendible structure 24 along theaxis 28 towards or away from the subject. AlthoughFIG. 9 only shows one arm/wheel/belt assembly, similar assemblies can be used to control each of the otherextendible structures 24. - It is to be appreciated that the components of the
device 26 can be designed for use inside a MR or other type of medical imaging scanner. In addition, the components can be constructed from available or readily manufactured from non-magnetic materials. -
FIG. 12 illustrates a method for positioning an ultrasound transducer used to treat portions of a subject/object with high intensity focused ultrasound (HIFU). The method includes using a device (e.g., the device 16) that provides at least three degrees of freedom for moving an ultrasound transducer (e.g., the transducer 14) towards or away from a subject through a translation and/or two rotational motions in connection with a medial imaging system (e.g., the MR scanner 54). The device also provides at least two degrees for moving the ultrasound transducer axially and longitudinally with respect to the subject. - At
reference numeral 130, thedevice 16 suitably positions theultrasound transducer 14 to an initial position for treating a particular region in the subject. Theultrasound transducer 14 is activated and anultrasound beam 12 is directed into the subject. At 132, theimaging system 54 is used to collect data representative of tissue in the treatment region and a temperature profile of the treatment region. Optionally, the temperature profiles are superimposed on the displayed image, e.g. by temperature depending shading. At 134, the operator determines from the data whether the position of the ultrasound transducer should be refined to further focus the beam at the treatment area. Assuming the operator desires to refine the position of the ultrasound transducer, at 136, the operator uses thecontrols 52 to extend or retract one or more of theextendible structures 24, as describe above, for example, through the arm andwheel system 100. Such movement results in translation and/or rotational movement of the beam to move the focus depth of the beam. Optionally, the operator uses thecontrols 52 to move thesupport 26 in a transverse and/or longitudinal direction with respect to the patient to move the beam to move a different transverse and/or longitudinal location. - The invention has been described with reference to the preferred embodiments. Modifications and alterations may occur to others upon reading and understanding the preceding detailed description. It is intended that the invention be constructed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (15)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US15/367,508 US20170079673A1 (en) | 2006-04-11 | 2016-12-02 | Device for positioning an ultrasound transducer inside a mr scanner |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US74460506P | 2006-04-11 | 2006-04-11 | |
PCT/US2007/064184 WO2008048708A2 (en) | 2006-04-11 | 2007-03-16 | A device for positioning an ultrasound transducer inside a mr scanner |
US29676908A | 2008-10-10 | 2008-10-10 | |
US15/367,508 US20170079673A1 (en) | 2006-04-11 | 2016-12-02 | Device for positioning an ultrasound transducer inside a mr scanner |
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Application Number | Title | Priority Date | Filing Date |
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US12/296,769 Continuation US9526515B2 (en) | 2006-04-11 | 2007-03-16 | Device for positioning an ultrasound transducer inside a MR scanner |
PCT/US2007/064184 Continuation WO2008048708A2 (en) | 2006-04-11 | 2007-03-16 | A device for positioning an ultrasound transducer inside a mr scanner |
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US20170079673A1 true US20170079673A1 (en) | 2017-03-23 |
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US12/296,769 Active 2033-07-21 US9526515B2 (en) | 2006-04-11 | 2007-03-16 | Device for positioning an ultrasound transducer inside a MR scanner |
US15/367,508 Abandoned US20170079673A1 (en) | 2006-04-11 | 2016-12-02 | Device for positioning an ultrasound transducer inside a mr scanner |
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US12/296,769 Active 2033-07-21 US9526515B2 (en) | 2006-04-11 | 2007-03-16 | Device for positioning an ultrasound transducer inside a MR scanner |
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JP (1) | JP5081227B2 (en) |
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WO (1) | WO2008048708A2 (en) |
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WO2010057067A2 (en) * | 2008-11-17 | 2010-05-20 | Sunnybrook Health Sciences Centre | Focused ultrasound system |
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EP2480286B1 (en) | 2009-09-24 | 2014-01-08 | Koninklijke Philips N.V. | High intensity focused ultrasound positioning mechanism |
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KR20140039418A (en) * | 2012-09-21 | 2014-04-02 | 삼성전자주식회사 | Medical robot system |
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WO2008048708A9 (en) | 2008-07-10 |
EP2007305B1 (en) | 2012-05-16 |
RU2471448C2 (en) | 2013-01-10 |
WO2008048708A3 (en) | 2008-11-27 |
US9526515B2 (en) | 2016-12-27 |
JP5081227B2 (en) | 2012-11-28 |
JP2009533162A (en) | 2009-09-17 |
WO2008048708A2 (en) | 2008-04-24 |
CN101484084A (en) | 2009-07-15 |
CN101484084B (en) | 2012-08-29 |
US20090069667A1 (en) | 2009-03-12 |
RU2008144406A (en) | 2010-05-20 |
EP2007305A2 (en) | 2008-12-31 |
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