US20170156733A1 - Multiple layer filamenyary devices for treatment of vascular defects - Google Patents
Multiple layer filamenyary devices for treatment of vascular defects Download PDFInfo
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- US20170156733A1 US20170156733A1 US15/415,669 US201715415669A US2017156733A1 US 20170156733 A1 US20170156733 A1 US 20170156733A1 US 201715415669 A US201715415669 A US 201715415669A US 2017156733 A1 US2017156733 A1 US 2017156733A1
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- braid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12159—Solid plugs; being solid before insertion
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- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
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Definitions
- the present invention is directed to braid-balls suitable for aneurysm occlusion and/or parent vessel occlusion/sacrifice (e.g., in treating neurovascular defects).
- the form of the ball is very important.
- the density of the device is paramount in applications where braid itself is intended to moderate or stop blood flow—allowing thrombosis within a volume formed by the ball.
- braid-ball type implants are provided in braid of sufficient density is provided to moderate blood flow within the volume of the implant. Upon thrombosis, flow thereto is stopped.
- a blood-barrier covering can be applied to the filamentary structure to immediately stop blood flow into the vascular site, in which the implant volume is set.
- the filaments of the braid matrix permit filling of the implant with blood when emplaced at a vascular treatment site. This blood then thromboses due to the flow-disruption effect(s).
- the ball devices are adapted to work alone—or in combination with each other to effect a complete treatment.
- high density braid/mesh is typically required. Namely, braid having at least about 48 ends, typically set at about 90 degrees or greater, in diameters from about 4 to about 8 mm may be employed. At larger diameters (e.g., about 6 to 12 or more), more wire ends (e.g., 64, 72 and upwards) may be employed in forming the balls.
- Suitable braid for constructing the balls may be obtained from Secant Medical, Inc. Wire diameters may be in the range of about 0.001 to about 0.003 inches, depending on desired delivery profile (which is typically less than about 0.050 inches).
- the braid forming the balls may incorporate only one size wire, or may be formed with multiple sizes.
- the wire is preferably superelastic NiTi alloy.
- the metal may be a binary alloy or a ternary alloy to provide additional radiopacity.
- radiopaque platinum fibers may be included in the braid, or the wire may comprise platinum or gold cord Nitinol DFT. Otherwise, wraps or bands (preferably Pt) used to secure the braid wire may serve as the sole radiopaque feature(s).
- the construction approaches described herein enable producing these useful devices. Whether comprising braid alone, or incorporating some further blood-barrier covering (such as a thin urethane film as may be applied by Hantel, Inc. or others) the use of braid presents numerous challenges in managing the termination of multiple wires and in forming the desired structures.
- detachable implant pushers that utilize a resistance wire heater to thermally sever a suture associated with the implant to effect release.
- the present invention contemplates a leave-behind tether.
- FIG. 1 is a photograph taken from U.S. Provisional Patent Appl. No. 61/046,670 (incorporated herein by reference) demonstrating actual reduction to practice of a single-layer braid ball device made according to the present invention
- FIGS. 2A and 2B are side-sectional views of the braid ball in isolation and in use, respectively;
- FIG. 3 illustrates a suture-melt resistance heater pusher for implant delivery
- FIGS. 4A-4F illustrate a production path of one implant embodiment encompassed by the current invention.
- a filamentary implant 2 is formed out of braid to treat vascular sites.
- Interwoven filaments 4 form a braid matrix 6 that define a self-expandable occlusion device.
- ties 10 as illustrated in FIG. 1
- bands 12 as illustrated in FIG. 2A and 2B .
- the expanded configuration defines an ovoid or roughly spherical shell 18 that is permeable to blood.
- the braid defining the proximal and distal ends of the implant turns or curves inward to a point where it is secured within the periphery of the shell.
- the inversion of the braid provides recessed securement of the braid resulting in atraumatic ends of the implant.
- the braid filaments optionally extend beyond the securing/securement features in order to define wire filament “tufts” 20 that will further promote thrombosis of blood that enters the ball upon deployment within a patient's vasculature.
- inset ends of the braid are demonstrated when the implant is in an expanded state to fill an aneurysm 26 off of a vessel 28 .
- FIG. 3 illustrates a detachable catheter/pusher 30 , optionally, for use in the present invention.
- it includes a resistance wire bridge 32 across insulated conductors 34 (a typical construction). What is unique is that the conductor wires are twinned/twisted along a length of the delivery pusher shaft 38 as shown. This configuration alleviates bending bias/preference.
- the tip thermally severs the polymer filament (e.g., suture 40 ) in contact therewith. At least the suture portion is received within the implant 2 (e.g., passing through a braid-securing band 12 ). The suture is retained in/with the implant upon actuation to release the implant by cutting through the suture with heat.
- polymer filament e.g., suture 40
- a ball stop 42 that is tied to the suture retains the filament in/with the implant is also illustrated.
- pusher 30 is shown received within a typical microcatheter 44 for vascular access, after passage therethough. Note also, other advantageous delivery system are referenced and described in the incorporated patent application.
- the intention is a method of manufacture including tying-off or otherwise securing a second end of a braid within an interior volume of a ball where other approaches would be impracticable.
- the technique may be employed in creating the balls (be they spherical or ovaloid in cross-section, etc.) out of one continuous section of braid. In so doing, joints and other delivery profile-increasing features are avoided—as well as potential areas for failure. Accordingly, the subject implants are extremely robust and fully recoverable to their aneurysmal shape as is required when they are delivered through a catheter in low profile. Robust shape recovery is required in treatments targeting distal vasculature, especially the tortuous neurovasculature encountered in human brains.
- FIGS. 4A-4F A detailed example of one process path for implant formation is illustrated in FIGS. 4A-4F .
- an final implant 2 may begin as a section 50 of braided material.
- the tubular braid stock is secured. As shown, it is tied-off with a wire wrap 10 . Such action develops an inset region 24 for the implant body.
- An opposite end of the braid is then captured in a transfer tube 52 .
- the tube is passed through the volume of the implant and secured with a second tie 10 at the other side.
- Additional refinement to the shape over that shown in FIG. 4E may be imparted within a shape-setting form 54 .
- Mandrels 56 including stops 58 received through the securement features may be employed to force apposition of the ball to the shape of the form when pulled apart as indicated by arrows.
- shape-setting in the form as appropriate to the selected material—e.g., as in heat setting superelastic Nitinol
- the mandrels are removed and the implant shaping is complete as shown in FIG. 4F .
- these additional forming steps are not necessary given that (in point of fact) the implant in FIG. 1 was produced without employing the same.
- any one of the subject implants is delivered to a target site employing known percutaneous catheter access techniques.
- the implant may be secured to a pusher (e.g., pusher 30 ) used to advance it through the access catheter (e.g., microcatheter 44 ).
- the implant Upon emplacement at the treatment site (e.g., cerebral aneurysm 26 as illustrated in FIG. 2A ), the implant can be detached.
- the suture 40 passing through the proximal end of the implant 2 is severed by melting it using a resistance heater. This retention/release fiber remains in and with the implant.
Abstract
Description
- This filing is a continuation of U.S. patent application Ser. No. 12/911,034, filed Oct. 25, 2010, which is a continuation of U.S. patent application Ser. No. 12/427,620 filed Apr. 21, 2009 which claims the benefit of each of: U.S. Patent Application Ser. Nos. 61/046,594 and 61/046,670, both filed Apr. 21, 2008; U.S. Patent Application Ser. Nos. 61/083,957 and 61/083,961, both filed Jul. 28, 2008; and U.S. Patent Application Ser. No. 61/145,097, filed Jan. 15, 2009. Each of the foregoing applications is incorporated herein by reference in its entirety.
- The present invention is directed to braid-balls suitable for aneurysm occlusion and/or parent vessel occlusion/sacrifice (e.g., in treating neurovascular defects).
- Especially for aneurysm treatment, but also for either one of the aforementioned treatments, the form of the ball is very important. In particular, the density of the device is paramount in applications where braid itself is intended to moderate or stop blood flow—allowing thrombosis within a volume formed by the ball.
- According to the present invention, braid-ball type implants are provided in braid of sufficient density is provided to moderate blood flow within the volume of the implant. Upon thrombosis, flow thereto is stopped. Alternatively, a blood-barrier covering can be applied to the filamentary structure to immediately stop blood flow into the vascular site, in which the implant volume is set.
- In either case, to form thrombosis within the volume of the ball, the filaments of the braid matrix permit filling of the implant with blood when emplaced at a vascular treatment site. This blood then thromboses due to the flow-disruption effect(s).
- Unlike Nitinol tube-cut cages that may be suitable for (or assist) in coil retention, the ball devices are adapted to work alone—or in combination with each other to effect a complete treatment. As such, high density braid/mesh is typically required. Namely, braid having at least about 48 ends, typically set at about 90 degrees or greater, in diameters from about 4 to about 8 mm may be employed. At larger diameters (e.g., about 6 to 12 or more), more wire ends (e.g., 64, 72 and upwards) may be employed in forming the balls.
- Suitable braid for constructing the balls may be obtained from Secant Medical, Inc. Wire diameters may be in the range of about 0.001 to about 0.003 inches, depending on desired delivery profile (which is typically less than about 0.050 inches). The braid forming the balls may incorporate only one size wire, or may be formed with multiple sizes.
- The wire is preferably superelastic NiTi alloy. The metal may be a binary alloy or a ternary alloy to provide additional radiopacity. Alternatively, radiopaque platinum fibers may be included in the braid, or the wire may comprise platinum or gold cord Nitinol DFT. Otherwise, wraps or bands (preferably Pt) used to secure the braid wire may serve as the sole radiopaque feature(s).
- In any case, the construction approaches described herein enable producing these useful devices. Whether comprising braid alone, or incorporating some further blood-barrier covering (such as a thin urethane film as may be applied by Hantel, Inc. or others) the use of braid presents numerous challenges in managing the termination of multiple wires and in forming the desired structures.
- Also included in the invention are detachable implant pushers that utilize a resistance wire heater to thermally sever a suture associated with the implant to effect release. As distinguished from known approaches where an implant is retained by a loop connected back to a delivery system pusher that is withdrawn with the devilry system, the present invention contemplates a leave-behind tether.
- Further details, variations, modification and optional features of the invention may be appreciated by review of any of the incorporated patent applications. However, the priority date and subject matter included in the appended claims rely solely on the subject matter filed in U.S. Provisional Patent Application Nos. 61/046670 and 61/046594, the earliest patent applications (each filed Apr. 21, 2008) one which U.S. patent application Ser. No. 12/427,620 relies. Selected figures from the '670 and '594 application and all of text from the '594 application—all—incorporated by reference in the parent application hereto is reproduced herein.
-
FIG. 1 is a photograph taken from U.S. Provisional Patent Appl. No. 61/046,670 (incorporated herein by reference) demonstrating actual reduction to practice of a single-layer braid ball device made according to the present invention; -
FIGS. 2A and 2B are side-sectional views of the braid ball in isolation and in use, respectively; -
FIG. 3 illustrates a suture-melt resistance heater pusher for implant delivery; and -
FIGS. 4A-4F illustrate a production path of one implant embodiment encompassed by the current invention. - Implants
- Referring to the figures, a
filamentary implant 2 is formed out of braid to treat vascular sites. Interwoven filaments 4 form abraid matrix 6 that define a self-expandable occlusion device. - As single layer of the braid is provided in which ends of the braid are secured and managed to provide an atraumatic interface. Specifically, ties 10 (as illustrated in
FIG. 1 ) or bands 12 (as illustrated inFIG. 2A and 2B ) secure filament theends 14 of the braid from which the implant is constructed. - In the implant variation pictured, the expanded configuration defines an ovoid or roughly
spherical shell 18 that is permeable to blood. The braid defining the proximal and distal ends of the implant turns or curves inward to a point where it is secured within the periphery of the shell. - The inversion of the braid provides recessed securement of the braid resulting in atraumatic ends of the implant. The braid filaments optionally extend beyond the securing/securement features in order to define wire filament “tufts” 20 that will further promote thrombosis of blood that enters the ball upon deployment within a patient's vasculature. However configured in regard to braid filament end securement and termination, inset ends of the braid (proximal and
distal insets 22/24, respectively) are demonstrated when the implant is in an expanded state to fill ananeurysm 26 off of avessel 28. - Delivery Systems
-
FIG. 3 illustrates a detachable catheter/pusher 30, optionally, for use in the present invention. Generally, it includes aresistance wire bridge 32 across insulated conductors 34 (a typical construction). What is unique is that the conductor wires are twinned/twisted along a length of thedelivery pusher shaft 38 as shown. This configuration alleviates bending bias/preference. Upon application of voltage, the tip thermally severs the polymer filament (e.g., suture 40) in contact therewith. At least the suture portion is received within the implant 2 (e.g., passing through a braid-securing band 12). The suture is retained in/with the implant upon actuation to release the implant by cutting through the suture with heat. A ball stop 42 that is tied to the suture retains the filament in/with the implant is also illustrated. Finally,pusher 30 is shown received within atypical microcatheter 44 for vascular access, after passage therethough. Note also, other advantageous delivery system are referenced and described in the incorporated patent application. - Methods of Manufacture
- Included in the intention is a method of manufacture including tying-off or otherwise securing a second end of a braid within an interior volume of a ball where other approaches would be impracticable. The technique may be employed in creating the balls (be they spherical or ovaloid in cross-section, etc.) out of one continuous section of braid. In so doing, joints and other delivery profile-increasing features are avoided—as well as potential areas for failure. Accordingly, the subject implants are extremely robust and fully recoverable to their aneurysmal shape as is required when they are delivered through a catheter in low profile. Robust shape recovery is required in treatments targeting distal vasculature, especially the tortuous neurovasculature encountered in human brains.
- A detailed example of one process path for implant formation is illustrated in
FIGS. 4A-4F . As shown inFIG. 4F anfinal implant 2 may begin as asection 50 of braided material. The tubular braid stock is secured. As shown, it is tied-off with awire wrap 10. Such action develops aninset region 24 for the implant body. An opposite end of the braid is then captured in atransfer tube 52. The tube is passed through the volume of the implant and secured with asecond tie 10 at the other side. - Additional refinement to the shape over that shown in
FIG. 4E may be imparted within a shape-settingform 54.Mandrels 56 includingstops 58 received through the securement features may be employed to force apposition of the ball to the shape of the form when pulled apart as indicated by arrows. After shape-setting in the form (as appropriate to the selected material—e.g., as in heat setting superelastic Nitinol) the mandrels are removed and the implant shaping is complete as shown inFIG. 4F . However, these additional forming steps are not necessary given that (in point of fact) the implant inFIG. 1 was produced without employing the same. - Methods of Use
- Any one of the subject implants is delivered to a target site employing known percutaneous catheter access techniques. The implant may be secured to a pusher (e.g., pusher 30) used to advance it through the access catheter (e.g., microcatheter 44). Upon emplacement at the treatment site (e.g.,
cerebral aneurysm 26 as illustrated inFIG. 2A ), the implant can be detached. With the exemplary system shown inFIG. 3 , thesuture 40 passing through the proximal end of theimplant 2 is severed by melting it using a resistance heater. This retention/release fiber remains in and with the implant.
Claims (21)
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US11357511B2 (en) | 2008-05-01 | 2022-06-14 | Aneuclose Llc | Intrasacular aneurysm occlusion device with globular first configuration and bowl-shaped second configuration |
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US11284901B2 (en) | 2014-04-30 | 2022-03-29 | Cerus Endovascular Limited | Occlusion device |
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