US2196199A - Preventing coagulation of blood - Google Patents
Preventing coagulation of blood Download PDFInfo
- Publication number
- US2196199A US2196199A US117961A US11796136A US2196199A US 2196199 A US2196199 A US 2196199A US 117961 A US117961 A US 117961A US 11796136 A US11796136 A US 11796136A US 2196199 A US2196199 A US 2196199A
- Authority
- US
- United States
- Prior art keywords
- blood
- coagulation
- metals
- neodymium
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/22—Blood coagulation
Definitions
- This invention relates to the. treatment of blood for the purpose of preventingits coagulation.
- the minimum concentration of ions required for preparing non-coagulating blood by means of magnesium ions is calculated attwo tenths millimole for 4 cm plasma or millimole if oxalate ions are used.
- Another object of my invention is to prevent 26 the coagulation of blood by means of practically insoluble or difii cultly soluble substances.
- the instruments or accessory implements may be covered, e. g., with neodymium or the respective oxides, only at the surfaces contacting with the blood.
- Non-coagulating plasma is prepared in this "10 way, that the blood is extracted and is first made non-coagulating according to the aforesaid meth- 0d and'is separated from the not dissolved component parts by'means of acentrifugegor by sedimentation or similar methods.
- method is to make the blood run directly into the centrifuge beaker made from, or covered with, the metals of the rare earths, and to subject the blood'at once to'the centrifuging process.
- cording-to my invention of a rare earth metal at the points contacting with the blood.
- Fig. 1 is a view of an injection syringe
- Fig. 2 illustrates, by way of example, a centrifuge beaker adapted to the preparation of noncoagulating plasma or to collect the blood for the purpose of blood transfusion.
- the receptacles are of the usual shape, dif- Q fering, however, from those hitherto used in this respect'that the injection pipe of the syringe. consists'of neodymium, and that the cylinder as well as the piston are .covered with neodymium.
- the inside of the centrifuge beaker is also covered with metallic neodymium.
- the small pipes used,-e. g., during blood transfusions are covered inside with a film ofmetallic neodymium. In this place of metallic neodymium also neodymium oxide may be used, 40
- a preferred ll The P1 Pr e t ng the coazulation of blood or plasma in a container or the like or blood or plasma in a container or the like comprising providing the container or the like comprising coating the inside surface of the eonwith an inside surface of a substance selected tainer or the like with metallic neodymium, from the group consisting oi! rare earth metals 3.
Description
April 9, 1940. H. DYCKERHOFF 2,196,199
PREVENTING COAGULATION OF BLOOD Filed Dec. 28, 19ss Patented Apr. 9, 1940 2,196,199 PREVENTING COAGULATION OF BLOOD I V Hanns Dyckerhofl', Munich Germany ApplicationDecember as, 1936, Serial No. 117,961
In Germany December 21, 1935 4 m (01. 167-78) This invention relates to the. treatment of blood for the purpose of preventingits coagulation. I
Hitherto magnesium ions 'or"oxalate. ions have been used'for producing non-coagulating blood orplasma. Of both ions, however, rather high concentrations were-requiredfor preventing coagulation; there was the further drawback of rather powerful toxic effects, whichdefinitely o barred the transfer of non-coagulatingblood,
prepared in this way, fromjthe bodyof; the. dispensing'person into the .body of the diseasedv "person in the case of bloodtransfusions. The minimum concentration of ions required for preparing non-coagulating blood by means of magnesium ions is calculated attwo tenths millimole for 4 cm plasma or millimole if oxalate ions are used.
It is an objectof my invention to make it pos o sible to carry out blood v transfusions without danger of coagulation of the blood and while,
avoiding'the addition to the blood of substances having a toxic effect. v
Another object of my invention is to prevent 26 the coagulation of blood by means of practically insoluble or difii cultly soluble substances.
I have foundthat the metals of the rare earths and their diflicultly soluble and insoluble combinations are especially adapted to prevent or I 30 check coagulation of the blood. The coagulation of the blood can be prevented or checked after it has been extracted from the body. This method of applying the, process is of practical importance, e. g., for carrying out blood'transfu- I have found that the effect of preventingqblood coagulation may be obtained already by means of the metals of the rare earths themselves or by means of their diflicultly soluble compositions; 40 e. g., by this means that containers or conduits and similar conveyances. contacting with the blood are used, which consist of, or are covered with, metals or diflicultly soluble compositions of these metals; d
45 This action of the metals of the rare earths or their diflicultly soluble compositionsis of practical importance, before all,- when carrying out transfusions of blood, but also during other operations, where instruments and similar objects made from metal contact with the blood. By
using syringes with injection pipes-if necessary also cylinder and piston-made from, or covered with, metal of the rare earths or of theirinsoluble compositions such as oxides by trans- 55 ferring the-blood through pipes or collecting it in blood, and at 0.65 tenth beakers or similar containers made from, or covered with, thematerials aforesaid, the coagulation of the blood is prevented'owing to the -described action of the earth metal ions. As-is known to the art in view of other metals and the like, the instruments or accessory implements may be covered, e. g., with neodymium or the respective oxides, only at the surfaces contacting with the blood. v i Non-coagulating plasma is prepared in this "10 way, that the blood is extracted and is first made non-coagulating according to the aforesaid meth- 0d and'is separated from the not dissolved component parts by'means of acentrifugegor by sedimentation or similar methods. method is to make the blood run directly into the centrifuge beaker made from, or covered with, the metals of the rare earths, and to subject the blood'at once to'the centrifuging process.
In the drawing, accompanying this specification '20 and forming part thereof, two receptacles are illustrated byway of example, which consist, ac-
cording-to my invention, of a rare earth metal at the points contacting with the blood.
Fig. 1 is a view of an injection syringe;
Fig. 2 illustrates, by way of example, a centrifuge beaker adapted to the preparation of noncoagulating plasma or to collect the blood for the purpose of blood transfusion.
The receptacles are of the usual shape, dif- Q fering, however, from those hitherto used in this respect'that the injection pipe of the syringe. consists'of neodymium, and that the cylinder as well as the piston are .covered with neodymium. The inside of the centrifuge beaker is also covered with metallic neodymium. In a similar way also the small pipes used,-e. g., during blood transfusions are covered inside with a film ofmetallic neodymium. In this place of metallic neodymium also neodymium oxide may be used, 40
which maybe burnt onto a layer of another material.
' It will be understood that, the foregoing description is in illustration and not in limitation.
tvarious' alternative procedures may be adopted within the scope of the appended claims in which it is my intention to claim broadly all novelty inherent in the invention.
I claim:
1. The process of preventing the coagulation of blood or plasma in a container or the like comprising coating the inside surface of the container or the like 'with a substance selected from the group consisting of the rare earth metals and their diflicultly soluble and insoluble compounds.
A preferred ll The P1 Pr e t ng the coazulation of blood or plasma in a container or the like or blood or plasma in a container or the like comprising providing the container or the like comprising coating the inside surface of the eonwith an inside surface of a substance selected tainer or the like with metallic neodymium, from the group consisting oi! rare earth metals 3. The process of preventing the coagulation of and their difllcultly soluble and insoluble com- I blood or plasma in a container or the like compounds, and maintaining the blood or plasma in prising coating the inside surface of the concontact with the said inside suriace. tainer or the like with neodymium oxide.
4. The process of preventing the coagulation HANNS DYCKERHOFF.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2196199X | 1935-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
US2196199A true US2196199A (en) | 1940-04-09 |
Family
ID=7989576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US117961A Expired - Lifetime US2196199A (en) | 1935-12-21 | 1936-12-28 | Preventing coagulation of blood |
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US (1) | US2196199A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2855933A (en) * | 1952-04-04 | 1958-10-14 | American Hospital Supply Corp | Fluid receptacle |
US2960498A (en) * | 1956-04-02 | 1960-11-15 | Burke Oliver W Jun | Partial glycerol esters of pectic substances and preparation thereof |
US4680177A (en) * | 1982-04-28 | 1987-07-14 | Trustees of the Garfield Weston Trust for Research into Heart Surgery | Processes for the production of blood products |
US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
US20070043376A1 (en) * | 2003-02-21 | 2007-02-22 | Osteobiologics, Inc. | Bone and cartilage implant delivery device |
-
1936
- 1936-12-28 US US117961A patent/US2196199A/en not_active Expired - Lifetime
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2855933A (en) * | 1952-04-04 | 1958-10-14 | American Hospital Supply Corp | Fluid receptacle |
US2960498A (en) * | 1956-04-02 | 1960-11-15 | Burke Oliver W Jun | Partial glycerol esters of pectic substances and preparation thereof |
US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
US4680177A (en) * | 1982-04-28 | 1987-07-14 | Trustees of the Garfield Weston Trust for Research into Heart Surgery | Processes for the production of blood products |
US20070043376A1 (en) * | 2003-02-21 | 2007-02-22 | Osteobiologics, Inc. | Bone and cartilage implant delivery device |
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