|Número de publicación||US2577780 A|
|Tipo de publicación||Concesión|
|Fecha de publicación||11 Dic 1951|
|Fecha de presentación||9 May 1950|
|Fecha de prioridad||9 May 1950|
|Número de publicación||US 2577780 A, US 2577780A, US-A-2577780, US2577780 A, US2577780A|
|Inventores||Lockhart Marshall L|
|Cesionario original||Compule Corp|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Otras citas (1), Citada por (81), Clasificaciones (17)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
Dec. 11, 1951 M. L. LOCKHART 2,577,780
CROWNED CUPPED ,RESILIENT PLUG FOR CYLINDRICAL PASSAGES Filed May 9, 1950 'JJJIMJIIJMIIIIIJMFJ Patented Dec. 11, 1951 UNITED STATES rarest orricr.
cRoWNnncUPP n RESILIENT PLUG- FOR CYLINDRICAL PASSAGES Marshall L; Lockhart, RutherfordLlN. J., assignor, by direct and mesne assignments, to The Com pule Corporation, Rutherford,
.. ration of New Jersey N; J.,- a corpo- Application May '9, 1950, Serial No. 160,987
. tures which may serve as a; piston plug'therein,
and is adapted especially'to use ihsme'di'cinal storage vials, ampules, hypodermic injection syringes; etc.
A general object of the present invention is to provide such plugs from resilient -m'aterial, generally of a crowned cupped shape, which are easily and economically'rnass produced and which permit use thereof efficiently as-stoppersfor tubular structures, as piston plugs for expelling .fiuids. from ampule tubes and syringe barrels,
or as partitioning'means in tubes readily provided, if desired, with piercedslits effectively to 'serve as efficient one-way valves, i. e., permitting passage of fluids under pressure from within the cupped chambers in the plugswhile blocking reverse fiow; the crowned closure endsof the plugs being of such shape and soproportioned as to avoid any tendency to bulge laterally with in- ,ent zone so proportioned and disposed as to prevent undue lateral bulging. thereof with in-folding under pressure applied either mechanically or by means of fluid so that folds thereof will not extend laterally an appreciable distance beyond the outermargins of the plug to overlap edges ofthe tubular structure when employed as a stopper in an end thereof.
Another object of thepres ent. invention is to providelsuch a crowned cupped resilient plugv in which the domed closure end-is readily pierceable to. provide fluid passage slits which permit escape of fluid when pressurethereof is applied. internally; of the hollow plug andwhich maybe effectively closed to passage of fluid when pressure thereofislappliedto the outside offt h'e domed end with resultant inefolding' oflthelatter sothat .tn mg; may serve as a one-wayfvaive; the. stifieneenp of the domed closure end alsoflbeing re di y i abl i' h et;i permi passagetherethrough of a withdrawing needle,
2 such" as that of a hypodermic syringe, and in'such case allowing use of the inherent action of the domed end with periodic application thereto and relief therefrom of pressure effectively to provide aspirating action.
A further object of the present invention is to provide structural embodiments of the plug of the present invention which may be readily made and allow eflicient use and operation thereof for a variety of purposes, as will be more fully apparent from the following description,
Other objects of the invention will in part be obvious and will in part appear'hereina'fter.
The invention accordingly comprises an article of manufacture possessing the featuresproperties; and the relation of elements which will be exemplified in the article hereinafter described and the scope of the invention will be indicated in the claims;
For a fuller understanding of the nature'a-nd objects of the invention, reference should be had to the following detailed description taken in connection with the accompanying drawingyin which:
- Fig. 1 is an enlarged side view of an embodiment of thecrowned cupped resilient plug of the present invention;
Fig. 2 is an end view shown in Fig; 1 as-observed from the domed closure end thereof;
Fig. 3 is-a longitudinal sectional view, taken substantially on line 3-3 of Fig. 2; r
Fig. 4 is a sectional View, with parts broken away, of a tube and the plug shown in Figs. 1, 2 and 3 with the latter positioned in an end of the former to serve as a stopper while permitting its use, if desired, .as a piston plug, -and-with-=the domed closure end relaxed;
Fig.- 5 is a sectional view similar to Fig:-4 but showingthe in-folding of the domed closure end with application of pressure-thereto externally, a dot-dash lineposition of the so in-folded' plug being indicated to illustrate its usev as a: piston plug;
.Fig..6 is an axial section to a smaller scale of an ampule comprising a tube closed at one end and plugged at the other by the plug illustrated inFigs. l to 5 inclusive, showing afragment of a piston. post or thrust member associated needle of a syringe structure;
Fig. '7 is a view Similarto Fig. 6 showing infolding of the domed cl'osureend of the plug when pressure is applied thereto by means-of the. piston post of the syringe after the-needle has pierced therethrough; I v f 8.is -a view similar to Fig; 6 showing, the
relative position of the parts upon relief of the pressure applied in connection with the Fig. '7 illustration so as to provide aspirating action;
Fig. 9 is an axial section of a tubular structure or barrel in which the plug of the present invention is located to serve as a one-way valve partition structure, with another piston plug being employed to create hydraulic pressure in contained liquid to force the latter from the interior chamber of the crowned cupped plug through pierced slits in its domed closure end; and
Fig. is a side elevational view of a modified form of the crowned cupped resilient plug of the present invention shown in Figs. 1 to 9 inclusive wherein the base sleeve section has a truly cylindrical external surface free from circumferential grooving; that view including in dotted lines a portion of a tube having a waist constriction with the plug serving at the constriction as a partitioning means.
Cupped rubber plugs have been commonly used in ampules and syringe barrel structures to serve as stoppers therefor and to act when desired as piston plugs for discharge of liquid contents when mounted in suitable syringe structures, as will be noted from my prior Patent 2,490,447 of December 6, 1949. However, when such plugs are closed off at the end by a transversely-extending wall, they are of limited use, since aspiration of a desired degree is not practically attainable therewith. Highly crowned plugs which permit a desired degree of aspiration have been used, but when the crown of such a plug projects from the end of a tubular barrel structure or ampule, external pressure thereagainst causes it to flop over or bulge laterally to beyond the edge of the tube, thus undesirably interfering with certain uses of the plug, such as for a piston plug. These and other difficulties of prior art attempts are efficiently eliminated by the crowned cupped resill ient plug of the present invention, which additionally permits effective use thereof as a blocking or one-way valve partition at a point between the ends of tubular structures.
As will be seen from the drawing, in which like numerals identify similar parts throughout, an embodiment of the present invention illustrated in Figs. 1 to 8 inclusive may comprise a body ll of resilient material, such as synthetic or natural rubber or gum and the like, having a substantiallycylindrical base sleeve section l2 and a domed protruding closure end is circumferentially joined to the former at its outer end l4. As best seen in Fig. 3, the walls of the base sleeve section 12 are relatively thick to be appreciably resistive to distortion while permitting limited diametrical constriction to allow a fluid-type fit into a tubular structure, such as a circular hole, tube or cylindrical barrel. The domed protruding closure end I3 is provided with a stiffened transversely-extending central section Hi to define between its margins and the outer end I4 of the base sleeve section I2 a substantially conical zone portion H, which, as will be seen from Fig. 3, is formed of relatively thin stock so as to be of greater flexibility than both the central section and the base sleeve section. Preferably, the central section 16 is formed by a circular protrudin rib l8 arranged about a circular, relatively thin-walled, transverse tip membrane l9, so that the latter is easily pierceable by a needle while serving as a part of the relatively rigid central section i5. However, it will be un derstood that all of the central section [B may if desired, be in the form of a relatively pad of substantially uniform thickness, particularly if the use of the plug is such as not to require central piercing thereof by a needle or should certain resistance to such piercing be unobjectionable.
As indicated in Fig. 3, the outer surface of the zone I! preferably has its generatrix, as represented by the dotted line 20, disposed substantially at an angle X of about 45 to the plug axis, as represented by a dot-dash line 2!. It has been found, in accordance with the present invention, that 45 is about the minimum limit of that angle in order to assure elimination of any tendency for the domed protruding end it to flop over under external pressure or to bulge laterally to an interfering degree. It is to be under- 7 stood that the domed protruding end I 3 may,
within the scope of the present invention, be flatter than that shown by way of example in the drawin so that angle X approaches to within a few degrees of with the plug axis 2!. However, the flatter the domed protruding end i3 is, the lesser is the aspirating action which is attainable by the plug. It will thus be seen that in the preferred embodiments the zone I! is in the shape of the surface of a frustum of a right cone, but other shapes thereof which closely approach the same while possibly providing slightly curved Walls'in that zone, either convex or concave to a small degree, are contemplated within the scope of the present invention and the terminology used herein.
In the preferred embodiments shown in the drawing, the bore 22 of the base sleeve section (2 is preferably constricted or throated at 23 to assure an appreciable thickness of the walls 15, at least at that point, for attainment of the desired relative resistivity to distortion or rigidity. The
bore 22 is flared out as it, approaches the outer end M of base sleeve l2 so as to permit circumferential connection thereto of the base end of the frusto-conical section [1 at an appreciable diametrical distance from the axis 2|, thereby assuring a fair width of the flexible zone to permit good flexing action. It will thus be seen from Fig. 3 that the chamber 24 provided within the crowned cupped resilient plug I! is substantially bulbous.
I In the structure shown in Figs. 4 and 5, tube 25 may be an end portion of a syringe barrel or an ampule of the type shown in my prior patent identified above, with one end closed by the plug H. of the resent invention. Assuming that the tube 25 is the cartridge sleeve of an am ule intended for use in a Cock type of syringe, as illustrated in U. S. Patent 1,661,818 of March 6, 1928, so as ts serve as the'bar'rel thereof, the crowned cupped plug H of the present invention serves as the closing piston plug in one end thereof. It is well understood in the art that in order to discharge liquid contents or such a. barrel through the needle of such a syringe structure, such piston plug is forced to slide down therein by depression of a suitable plunger. In Fig. 5, responsive distortion of the present plug to such plunger action is illustrated. It will there be seen that with application of pressure externally to the protruding tip of the plug. II, as diagrammatically indicated by the arrow 26, the domed protruding closure end I3 is distorted inwardly with flexure of the zone l1. During such flexure of zone ll, there is no appreciable lateral bulging of the plug in the vicinity of the end M of base sleeve I2, or any .of such degree as to cause the formation, of. a $01 1. which would overmam-mo.
:lap -the edge' 21 of the; tube 23 torsuchean: extent as to" intei'f ere with piston -sliding action: thereof. "Such. piston action. is "illustrated ".5 -xb 1z 'a dot-dashoutline at*28, which represents'the location of the plug: when: pushed" inwardly the dis.- tancebetween the 130111135 29 .andf30. Therm;- folding of the tip I3 hasbeen aeimggerated. in
Fig; 5 in order toavoid anypossible" confusion the: showing of that figure.
In-Fig; 6; the tube 25 is illustrated aszaniampule adapted to-serve as the-barrel: ofxa syringe structure of the type illustrated; in my above identified patent. Ampule tube 25 of Fig; 6 contains a body 3 I of medicinal solution intended for; hypodermic injection; with i the end :of thei'tube suitably-=closed off by plug II. of; the. present .tinvention. A portion of pistona-post:ortthrust'memb'er 32 of" the syringe: structureuand thezassociated inner end 33 of. a' double-ended: injection needle .are' shown with the 'latter'being thrust intcs'the membrane: I9. 'After the syringe needle has been properly inserted into a patients flesh. the domed end of the plug H will-be depressed or'insfolded,
as shown in' Fig. 7,."by pushing"theampulei25 toward the: post or .thrust 'membert32. As a .2
result, the space withinu the; ampule' will: be: reduced so as momentarily totdischargelthrough the" needle a; small quantity of fluid contents. Then,.fupon relief 'ofpressurei against ampule 25,
asshown in Fig.1 8 the. resiliency of 'thexplug II will cause its domedend to protrude againwith suction being createdr onv needle .33, 'to'..:provide.1a
Idesired. aspiratinge action- The employment :of the 'plug of. the present invention. as a valved-partition in a tubularstructure .is illustrated in: Fig. '9" wherein a .portionof tube. I25 is shown fitted between. its ends with one of the plugs" I I- The latter preferably provided. with; a plurality of: pierced slits 34'34 in the .zone' [1,. such: asby: thrusting a. needle therethrough: at a plurality of points aboutflthe tip I6. As a result,'when' hydraulic pressure is applied chamber. 24 by" forcing :arpiston. plug 35' of usual construction. into the tube. in the direction of the arrow indicated, liquid I3I: will be caused tobulge the idomed end, as shown; with an. attendant? opening of the slits 34-34. Consequently, liquid is caused to passthrough the partitioniplug via the" open. slits 3'4''-34. .Their location in thezone ll ispreferred. since it will direct resulting jets of liquid against the; inner wallsoflthe tube I25, rather than axially togive a fountain actionwhich may be undesirable. If, however, such fountairr- -action is not objectionable, membrane l9 within the stiffening rib I8 may also be provided with a needle-pierced slit I 34 to supplement the action of the slits 34-44. The opening of the slits 34-34 and I34 under hydraulic pressure applied internally of chamber 24 is, of course, caused by the stretching of the relatively thin flexible walls of zone I! and the central membrane I9 as the domed end of the plug II is bulged under the application of pressure within the chamber, as is well illustrated in Fig. 9. Upon relief of hydraulic pressure with cessation'of sliding motion of piston plug 35, the domed end of the piston plug II will relax so that the pierced slits 34-34 and I 34 will naturally close by contraction of the resilient walls of zone I! and membrane I9. Those slits will remain effectively closed against any pressure applied externally of the domed end since such application of externalpressure will fold it inwardly, such as-is indicated in Fig. 4, and in such distorted disposition, the needle-pierced slits remain-efiectively closed against passage of fluid.
"Iii'Fig: mes 'showni in fulllines at. I l'lzanother embodimentzof thexpl'uguof the: presentinvention 'preferred'when it is desired to 'u'sethe' sameas a partitioning: means in a tubular; structure having a constricted waist; such as that indicated-in dotted lines at I2 5. and 31: respectively in Fig.1.10. lThe constricted waist-.31.:of1course, mayzbezso dimensioned as to serve eitherrasaa permanent seat for? such I a partitioning,plug. or as means intended only: temporarily tor retard sliding action of plug II I upon-application: of pressure thereto.
It willv thus. be seen: that the. objects set forth above,.among those made apparent; from the rpreceding description, are. efficiently attained and, since certain changes may be. made. in the: above article, and different. embodiments: off'the; invention could be made without departing fromithe scope thereof, it is intendedthat" all matter'contained in the" above deseription'or' shown. in the accompanying drawing shall be=*interpreted as illustrative arid. not in a limiting sense.
It is alsotobe understood that the following claims are intended" to cover "all of the generic and specificfeaturesof the invention herein described; and all" statements of 'the'scope of the invention which; as a matter 'of'language, might be said to fall therebetween.
Having described my invention, what I claim as new and desire to secure by Letters Patent is:
1. crowned cupped resilient plug for tubular structures comprising a hollow, substantially cylindrical basesleeve section having relatively thickwalls to'be appreciably resistive to distortion while permitting-limited diametrical constriction" to allowfluid-tight fitting into a tubular structure; a domed, protruding closure end circumferentially joined to'one end of said sleeve section; and a stiffened, transversely-extending. central sectionv onsaid domed closure end defining between its margin and said sleeve section a substantially conical'zone portion, said closure end Zone being of greater flexibility than said central section and said'sleeve section with the g'enerat'r'ix of'the outer surface of said zone being disposed substantially at an angle to the axis of said plug of between about 45 and a few degrees less than 2. The crowned cupped resilient plug as defined in claim 1 characterized by the provision of said zone portion in substantially the shape of the surface of a frustum of a right cone with the thickness thereof being substantially less than the thickness of the Walls of said base sleeve section and said stiffened central section to assure relatively greater flexibility.
3. The crowned cupped resilient plug as defined in claim 2 characterized by a disposition of the wall of said zone portion relative to the axis of said plug resulting from arrangement of the generatrix of its outer surface at an angle of about 45- to said axis.
4; The crowned cupped resilient plug as defined in claim 3 characterized by the provision of normally-closed, pierced slits in said domed closure end permitting said plug to serve as a one-way valve with said slits opening under fluid pressure applied from within said base sleeve section and closing with in-folding of the domed closure and upon application of fluid pressure externally thereto.
5. A crowned cupped resilient plug for tubular structures comprising a body of resilient material including a base sleeve provided with rela tively thick walls to assure relative rigidity; a relatively thin-walled, highly flexible, frusto-conical section circumferentially joined at its base to and protruding from one end of said sleeve with the generatrix of its outer surface arranged at an angle to the axis of said plug of between about 45 and a few degrees less than 90; and a stiffer, transversely-extending, axially-located section closing off the outer smaller end of said frusto-conical section.
6; A crowned cupped resilient plug for tubular structures comprising a body of resilient material including a base sleeve provided with relatively thick walls to assure relative rigidity; a relatively thin-walled, highly flexible, frusto-conical section circumferentially joined at its base to and protruding from one end of said sleeve with the generatrix of its outer surface arranged at an angle to the axis of said plug of about 45; and a stiffer, transversely-extending, axially located section closing off the outer smaller end of said frusto-conical section.
'7. A crowned cupped resilient plug for tubular structures comprising a body of resilient material including a base sleeve provided with relatively thick walls to assure relative rigidity; a relatively thin-walled, highly flexible, frusto-conical section cireumferentially joined at its base to and protruding from one end of said sleeve with the generatrix of its outer surface arranged at an angle to the axis of said plug of between about 45 and a few degrees less than 90; said frustoconical section having normally-closed pierced slits therein to be opened by fluid pressure applied from within said base sleeve; and a stiffer, transversely-extending, axially-located section closing off the outer smaller end of said frustoconical section.
8. A crowned cupped resilient plug for tubular structures comprising a body of resilient material including a base sleeve provided with relatively thick walls to assure relative rigidity; a relatively thin-walled, highly flexible, frusto-conical section circumferentially joined at its base to and protruding from one end of said sleeve with the generatrix of its outer surface arranged at an angle to the axis of said plug of about 45"; said vfrusto-conical section having normally-closed pierced slits therein to be opened by fluid pressure applied from within said base sleeve; and a stiffer, transversely-extending, axially-located section closing off the outer smaller end of said frusto-conical section.
9. A crowned cupped resilient plug for tubular structures comprising a body of resilient material including a base sleeve having relatively thick walls to assure relatively high rigidity and with its outer surface being substantially cylindrical to be fitted into a tubular hole; a relatively thin-walled, highly flexible frusto-conical section circumferentially joined at its larger base end to one end of said sleeve and protruding therefrom with the generatrix of its outer surface arranged at an angle of about 45 to the axis of said plug; and a stiffer, transverselyextending tip portion closing off the outer, smaller end of said frusto-conical section with a protruding circumambient external stiffening rib thereon arranged about a relatively thin needle-pierceable area thereof.
10. A crowned cupped resilient plug for tubular structures comprising a body of resilient material including a base sleeve having relatively thick walls to assure relatively high rigidity and with its outer surface being substantially cylindrical to be fitted into a tubular hole, the bore of said sleeve being enlarged at its outer end; a relatively thin-walled, highly flexible frusto-conical section circumferentially joined at its larger base end'to the outer end of said sleeve :and protruding therefrom with the generatrix of its outer surface arranged at an angle of about 45 to the axis of said plug; and a stiffer, transversely-extending tip portion closing off the outer smaller end of said frusto-conical section with a protruding circumambient external stiffening rib thereon arranged about a relatively thin needle-pierceable area thereof.
' 11. The crowned cupped resilient plug as defined in claim 10 characterized by the shaping of the bore in said'sleeve to provide near its inner open end a constricted throat with the walls of the bore gradually flaring from that constriction to' the wider portion thereof at its outer end so that said frusto-conical section is of maximum width to provide for free flexing action thereof.
' MARSHALL L. LOCKHART.
No references cited.
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US2693185 *||1 Dic 1951||2 Nov 1954||Compule Corp||Hypodermic syringe and aspirating ampoule thereof|
|US2848130 *||7 Oct 1953||19 Ago 1958||Duo Vent Vacuum Closure Compan||Pressure resistant closures|
|US2886203 *||1 Ago 1956||12 May 1959||Braun Goll Company||Plastic stopper and shield for a tap rod fitting for a barrel|
|US3009217 *||28 Feb 1958||21 Nov 1961||Chase Bottle & Supply Corp||Clinical thermometer retainer|
|US3075525 *||15 Jul 1959||29 Ene 1963||Mcconnaughey Robert K||Venting closures and separators for hypodermic syringes|
|US3089490 *||14 Mar 1960||14 May 1963||Graham Chemical Corp||Disposable cartridge type hypodermic syringes|
|US3091240 *||29 Dic 1958||28 May 1963||Milton J Cohen||Hypodermic syringe and ventable closure means|
|US3200984 *||14 Ago 1962||17 Ago 1965||Mueller Brass Co||Pressure seal plug|
|US3295525 *||7 Abr 1964||3 Ene 1967||Astra Apotekarnes Kem Fab||Self-aspirating cartridge ampoule|
|US3303846 *||8 Oct 1963||14 Feb 1967||Functional Container Corp||Mixing syringe having separate compartments for incompatible medicaments|
|US3682174 *||7 Oct 1969||8 Ago 1972||Milton J Cohen||Syringe for injection of freshly mixed liquid-powder|
|US3885549 *||29 May 1974||27 May 1975||Green David Thomas||Apparatus for producing a vacuum in a test tube|
|US3887464 *||27 Feb 1974||3 Jun 1975||Becton Dickinson Co||Serum/plasma separator with centrifugal valve seal|
|US3894950 *||27 Feb 1974||15 Jul 1975||Becton Dickinson Co||Serum separator improvement with stretchable filter diaphragm|
|US3894951 *||27 Feb 1974||15 Jul 1975||Becton Dickinson Co||Serum/plasma separator; interface seeking piston; resilient apertures in lower diaphragm type|
|US3894952 *||27 Feb 1974||15 Jul 1975||Becton Dickinson Co||Serum/plasma separator assembly having interface-seeking piston|
|US3897337 *||27 Feb 1974||29 Jul 1975||Becton Dickinson Co||Plasma separator assembly having interface-seeking piston with centrifugal valve|
|US3931010 *||27 Feb 1974||6 Ene 1976||Becton, Dickinson And Company||Serum/plasma separators with centrifugal valves|
|US3935113 *||27 Feb 1974||27 Ene 1976||Becton, Dickinson And Company||Serum/plasma separator with centrifugal valve|
|US3941699 *||27 Feb 1974||2 Mar 1976||Becton, Dickinson And Company||Plasma separator with centrifugal valve|
|US3972121 *||12 Ago 1974||3 Ago 1976||Nash John E||Pressure reducer for air driven dental handpiece|
|US4308689 *||7 Ene 1980||5 Ene 1982||Jenson Clark E||Tree medication capsule|
|US4640442 *||26 Jul 1985||3 Feb 1987||The Procter & Gamble Company||Dispensing package and follower deivce|
|US4671331 *||13 Mar 1986||9 Jun 1987||Lyphomed, Inc.||Cover for medicinal vial|
|US4728006 *||1 Oct 1984||1 Mar 1988||The Procter & Gamble Company||Flexible container including self-sealing dispensing valve to provide automatic shut-off and leak resistant inverted storage|
|US5188620 *||14 Jun 1990||23 Feb 1993||Baxter International Inc.||Pre-slit injection site and associated cannula|
|US5211638 *||21 Ene 1992||18 May 1993||Baxter International Inc.||Pre-slit injection site|
|US5658260 *||29 Jul 1996||19 Ago 1997||Baxter International Inc.||Bayonet lock cannula for pre-slit y-site|
|US5776125 *||24 Abr 1995||7 Jul 1998||Baxter International Inc.||Needleless vial access device|
|US5797897 *||6 Jun 1995||25 Ago 1998||Baxter International Inc.||Pre-slit injection site and tapered cannula|
|US5871500 *||5 Ene 1996||16 Feb 1999||Baxter International Inc.||Pre-slit injection site and tapered cannula|
|US5947326 *||12 Nov 1997||7 Sep 1999||Alasco Rubber & Plastics Corporation||Bung and stopper|
|US6102410 *||4 Feb 1998||15 Ago 2000||Yazaki Corporation||Rubber stopper for waterproof connector|
|US6193697||9 Abr 1999||27 Feb 2001||Baxter International Inc.||Pre-slit injection site and tapered cannula|
|US6213996||29 Oct 1998||10 Abr 2001||Baxter International Inc.||Pre-slit injection site and tapered cannula|
|US6217568||12 May 1995||17 Abr 2001||Edwards Lifesciences Corporation||Preslit injection site and tapered cannula for blood sampling|
|US6261266||29 Oct 1998||17 Jul 2001||Baxter International Inc.||Pre-slit injection site and tapered cannula|
|US6447498||29 Oct 1998||10 Sep 2002||Baxter International Inc.||Pre-slit injection site and tapered cannula|
|US6494463 *||6 Nov 2000||17 Dic 2002||Kurt J. Rank||Plug for sealing more than one size of hole|
|US6569125||17 Jul 2001||27 May 2003||Baxter International Inc||Pre-slit injection site and tapered cannula|
|US6571971 *||8 Feb 2001||3 Jun 2003||Weller Engineering, Inc.||Hermetically sealed container with pierceable entry port|
|US6605076||9 Ago 1996||12 Ago 2003||Baxter International Inc.||Pre-slit injection site and tapered cannula|
|US6976509||2 Ago 2004||20 Dic 2005||Kirvan Clifford J||Method and apparatus for pressurizing plastic pipe|
|US7713247||3 May 2006||11 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7713248||3 May 2006||11 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7713249||3 May 2006||11 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717883||3 May 2006||18 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717884||3 May 2006||18 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717885||3 May 2006||18 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717886||3 May 2006||18 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717887||3 May 2006||18 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7722575||3 May 2006||25 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7722576||3 May 2006||25 May 2010||Icu Medical, Inc.||Medical valve and method of use|
|US8002765||23 Ago 2011||Icu Medical, Inc.||Medical valve with fluid escape space|
|US8105314||25 Oct 2007||31 Ene 2012||Icu Medical, Inc.||Medical connector|
|US8394342||12 Mar 2013||Becton, Dickinson And Company||Density phase separation device|
|US8398607||19 Mar 2013||Icu Medical, Inc.||Medical connector|
|US8444628||21 May 2013||Icu Medical, Inc.||Needleless medical connector|
|US8454579||4 Jun 2013||Icu Medical, Inc.||Medical connector with automatic valves and volume regulator|
|US8628515||11 Mar 2013||14 Ene 2014||Icu Medical, Inc.||Medical connector|
|US8747781||21 Jul 2009||10 Jun 2014||Becton, Dickinson And Company||Density phase separation device|
|US8758306||12 May 2011||24 Jun 2014||Icu Medical, Inc.||Medical connectors and methods of use|
|US8794452||1 Ago 2013||5 Ago 2014||Becton, Dickinson And Company||Density phase separation device|
|US8870850||20 May 2013||28 Oct 2014||Icu Medical, Inc.||Medical connector|
|US8998000||14 May 2010||7 Abr 2015||Becton, Dickinson And Company||Density phase separation device|
|US9079123||6 Ago 2013||14 Jul 2015||Becton, Dickinson And Company||Density phase separation device|
|US9186494||2 May 2014||17 Nov 2015||Icu Medical, Inc.||Medical connector|
|US9192753||19 Jun 2014||24 Nov 2015||Icu Medical, Inc.||Medical connectors and methods of use|
|US9205243||21 Oct 2014||8 Dic 2015||Icu Medical, Inc.||Medical connectors and methods of use|
|US9238129||27 Oct 2014||19 Ene 2016||Icu Medical, Inc.||Medical connector|
|US9278206||4 Abr 2013||8 Mar 2016||Icu Medical, Inc.||Medical connectors and methods of use|
|US9333445||21 Jul 2009||10 May 2016||Becton, Dickinson And Company||Density phase separation device|
|US9339741||2 May 2014||17 May 2016||Becton, Dickinson And Company||Density phase separation device|
|US9364828||1 Ago 2013||14 Jun 2016||Becton, Dickinson And Company||Density phase separation device|
|US9415200||12 Nov 2015||16 Ago 2016||Icu Medical, Inc.||Medical connector|
|US20060203048 *||14 Mar 2005||14 Sep 2006||Scheffelin Joseph E||Plug|
|US20060206058 *||3 May 2006||14 Sep 2006||Lopez George A||Medical valve and method of use|
|US20060264891 *||3 May 2006||23 Nov 2006||Icu Medical, Inc.||Medical valve and method of use|
|US20100160135 *||21 Jul 2009||24 Jun 2010||Becton, Dickinson And Company||Density Phase Separation Device|
|US20100288694 *||14 May 2010||18 Nov 2010||Becton, Dickinson And Company||Density Phase Separation Device|
|USD644731||6 Sep 2011||Icu Medical, Inc.||Medical connector|
|Clasificación de EE.UU.||604/415, 215/247, 215/355|
|Clasificación internacional||B60G9/00, B60G11/00, B65D25/08, B65D25/04, A61M5/315, B60G11/22|
|Clasificación cooperativa||A61M5/31511, B65D25/08, B60G9/00, B60G11/22|
|Clasificación europea||B60G9/00, A61M5/315C, B60G11/22, B65D25/08|