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Número de publicaciónUS2653611 A
Tipo de publicaciónConcesión
Fecha de publicación29 Sep 1953
Fecha de presentación24 Nov 1950
Fecha de prioridad24 Nov 1950
Número de publicaciónUS 2653611 A, US 2653611A, US-A-2653611, US2653611 A, US2653611A
InventoresArthur E Smith
Cesionario originalArthur E Smith
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Closure
US 2653611 A
Resumen  disponible en
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Reclamaciones  disponible en
Descripción  (El texto procesado por OCR puede contener errores)

Sept. 29, 1953 A. E. SMITH 2,653,611

CLOSURE Filed Nov. 24, 1950 INVENTOR. AETHUPE SM/TH,

ATTOf/VE) Patented Sept. 29, 1953 UNITED STATES PATENT OFFICE CLOSURE Arthur E. Smith, Los Angeles, Calif.

Application November 24, 1950, Serial No. 197,358

4 Claims. 1

This invention relates to a closure for a container whereby a fresh drug solution may be prepared easily, quickly, accurately and may be maintained in a sterile condition.

Heretofore, it has been the practice among physicians, surgeons and nurses to prepare a fresh drug solution such as penicillin, or the like, by injecting a measured quantity of a solvent such as water or normal saline solution through a resilient bottle cap and into a bottle wherein a quantity of the dry drug had been placed. This process of mixing necessary fresh solutions permits considerable error in that not always does the preparer know or remember the exact amount of solvent to be used, the correct type of solvent, or does he necessarily maintain the solvent in a sterile condition. These measurements must be rigidly complied with to maintain the fresh drug solutions in their correct concentrations, a factor vital in the administration of such drugs.

The problem of sterility of the solution is one that must be taken into consideration. Often a quantity of solvent is withdrawn at many difierent times from the same container. In so doing it is practically impossible to maintain the solvent in a sterile condition. This condition is also aggravated by the fact that often there is poor sterilization of the syringes and needles in the mixing.

Therefore, it is the main object of this invention to provide a novel closure for a container whereby a fresh drug solution may be prepared rapidly and accurately and may be maintained in a sterile condition.

Another object of the present invention is to provide a novel container closure including a novel removable portion.

A further object of the invention is to provide a novel closure including a drug holding cavity.

A still further object of the present invention is to provide a novel closure including a drug holding cavity and a novel opening member for removing a wall of the cavity.

Other and further objects of the present invention will be apparent from the following description taken in connection with the accompanying drawings, wherein:

Fig. 1 is a sectional view of a container with the closure of this invention thereon;

Fig. 2 is a, view similar to Fig. 1, showing the container as it appears after the fresh solution has been prepared;

Fig. 3 is a transverse sectional view taken as indicated by line 3-3, Fig. 1;

Fig. 4 is an enlarged, fragmentary, sectional View of the actuating rod, together with the diaphragm and its associated frangible portion;

Fig. 5 is a fragmentary, sectional view of a modification of the invention, and

Fig. 6 is a view similar to Fig. 5, showing a further modification of the invention.

Referring to the drawing by reference characters, wherein like characters indicate like parts, the invention is shown as embodied in a container which is indicated generally at H]. As shown the container includes a bottle ll having a body portion l2 and a reduced neck portion [3. The upper end of the neck portion I3 is provided with an outwardly directed flange M which forms the upper end of an annular groove 15. The opening [6 in the bottle neck receives a stopper ll which has an outwardly directed annular flange I 8, adapted to rest on the flange M.

The stopper H has an opening l9 which is closed at the lower end by a diaphragm 20 which has a pair of opposed, upper and lower annular V-shaped grooves 2| and 22, which define a frangible or breakable portion 23. The portion 23, as shown, has a centrally positioned indentation 24 which is adapted to receive the lower end of an actuating member or rod 25, the upper end of which is retained in a collar which depends from a resilient, inverted, cup shaped closure member 28.

The closure member 28 has a downwardly extending side wall or skirt 29 which surrounds the flanges I4 and I8 of the bottle and the stopper and at its lower end has an inwardly directed annular bead 30 which lies in the groove l5 of the bottle neck I3 to retain the closure 28 in place. The central upper surface of the closure member 28 is provided with a slight indentation 3|, the use of which will be later described.

In use, the container is delivered to the user in the condition shown in Fig. l, with a quantity of a drug 32 in the space surrounding the rod 25 within the opening 19. The body I2 of the container is filled with the correct amount of the proper solvent or vehicle 33 for the drug being used.

To eifect mixing of the drug and the solvent, pressure is applied on the upper end of the closure 28, thus forcing the actuating member 25 downwardly and, due to its engagement with the frangible or breakable portion 23 of the diaphragm 20, causes the portion 23 to break away from the diaphragm 20 at the annular grooves 2| and 22. The rod 25, frangible portion 23 and the drug 32 will then fall into the solvent 33 to prepare a fresh solution. To obtain the required quantity of the prepared solution, a hypodermic needle connected to a syringe is inserted through the indentation 3! in the closure 28 and the required amount of solution is withdrawn into the syringe.

Thus it may be seen that the container of the invention is of such a nature that a fresh drug solution may be quickly, easily and accurately prepared and that the solution will remain sterile 1n the container.

Referring now to Fig. 5, wherein a modification of the invention is shown and wherein like parts are indicated by single primed reference numer als, the opening IS in the stopper ll receives H. An annular, V-shaped groove 43 is provided in the insert 40 adjacent the flange 4| to provide The flange 4| and a frangible area therefor.

groove 43 form a diaphragm. The insert 40 is;-

held in contact with the flange 42 by pressure on its upper end by the resilient closure 28. The insert 40 has an upwardly directed recess 44 wherein the drug 32' may be placed.

Pressure on the upper end of actuating member 4|! will cause the flange 4| to break from the insert 40 at the annular groove 43, whereupon the insert 40 together with the drug 32' will fall into the solvent 33 to be dissolved therein.

Referring now to the further modification of Fig. 6, wherein like parts are indicated by double primed reference numerals, the stopper I1" is provided with annular V-shaped opposed grooves 50 and 50 adjacent its upper flange l8. The flange l8 and V-sh-aped grooves 50 and 50 provide a diaphragm. A recess is provided in the lower portion of the stopper IT" to receive the drug 32".

Horizontal bores 52 connect the recess 5| with the outer periphery of the stopper. The recess 5| and the space 53 formed between the stopper I1" and the neck [3" of the bottle are sealed by a resilient closure 54 adapted to engage the opening IS" in the bottle neck and a roove 55 in the lower outer edge of the stopper H.

The stopper I7" is also provided, at its upper end, with a raised actuating member portion 56 which may be engaged by a closure 28". Pressure on the closure 28" and the portion 56 will cause the stopper IT" to break away from its flange l8 at the annular grooves 50 and 50', thus causing the stopper, lower closure 54 and the drug 32" to fall into the solvent 33", whereupon the solvent will pass through the bores 52 to be mixed with the drug 32".

Having thus described my invention, I claim:

1. In a container wherein a fresh drug solution may be prepared, a bottlehaving a body portion and a neck portion of reduced diameter, a stopper within said neck, portion and having an outwardly directed annular flange resting on the upper end of said neck portion, said stopper having an annular wall defining a recess adapted to hold a quantity of a drug, a removable diaphragm integral withsaid annular wall and closing said recess, an actuating rod in the stopper recess, said rod having a cross sectional area less than the area of the stopper recess, said actuating rod extending upwardly to a location above the upper end of said stopper flange, and an inverted cup shaped resilient closure member having a skirt portion engaging the stopper flange and engaging said bottle neck portion, said diaphragm and said closure having centering means thereon engaging the lower and, upper ends, respectively, of the rod.

2. In a container wherein a fresh drug solution may be prepared, a bottle having a body portion and a neck portion of reduced diameter, theupper end of said neck portion having an annular peripheral flange defining an annular groove about said neck portion adjacent to said body portion, a stopper within said neck portion and having an outwardly directed annular flange resting onthe upper. end of said neck portion, saidstopper having an. annularlwall defining a 4 recess adapted to hold a quantity of a drug, a diaphragm integral with said annular wall and extending across, and closing, said recess, there being a weakened portion on said diaphragm forming a removable section, an actuating rod in ,the stopper recess and having its lower end engaging said diaphragm, said rod having a cross sectional area less than the area of the stopper recess, means to center the lower end of said rod-on said diaphragm, said actuating rod extending upwardly to a location above the upper end of said stopper flange, and an inverted cup shaped resilient closure member having a skirt portion engaging the stopper flange, said skirt portion having an inwardly directed bead thereon engaging in said groove about said bottle neck portion, said closure having means thereon engaging the upper end of said rod to center the rod.

3. In a container wherein a fresh drug solution may be prepared, a bottle having a body portion and a neck portion of reduced diameter, the upper end of said neck portion having an annular peripheral flange defining an annular groove about said neck portion adjacent to said body portion, a stopper within said neck portion and having an outwardly directed annular flange resting on the upper end of said neck portion, said stopper having an annular wall defining a recess adapted to hold a quantity of a drug, a diaphragm integral with said annular wall and extending across and closing said recess, there being a pair of opposed annular V-shaped grooves on opposite sides of said diaphragm and forming a removable section, said removable section having a central indentation, an actuating rod in the stopper recess, said rod having a cross sectional area less than the area of the stopper recess and having its lower end arranged in said indentation, said actuating rod extending upwardly to a location above the upper end of said stopper flange, and an inverted cup shaped resilient closure member having a skirt portion extending over the stopper flange, said skirt portion having an inwardly directed bead thereon engaging in said groove about said bottle neck portion, said closure having a depending collar engaging the upper end of said rod.

4. In a container wherein a fresh solution may be prepared, a bottle having a body portion and a neck portion, a stopper within said neck portion and having an outwardly directed annular flange resting on the upper end of said neck portion, said stopper having an annular wall defining a recess adapted to hold a quantity of a drug, a removable diaphragm integral with said annular wall and closing said recess, an actuating rod in said stopper recess, said rod having a cross sectional area less than, the area of the stopper recess, said actuating rod extending upwardly to a location above the upper end of said stopper flange, and an inverted cup shaped resilient closure member having a skirt portion engaging the stopper flange and the bottle neck portion.

ARTHUR E. SMITH.

References Cited in the file of this patent UNITED STATES PATENTS Number Name Date 2,251,527 Smith Aug. 5, 1941, 2,275,567 Smith Mar. 10,1942 2,524,366 Smith Oct. 3, 1950 2,524,607 Smith Oct. 3, 1950

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US2251527 *3 Nov 19335 Ago 1941Smith Arthur ESyringe and ampoule
US2275567 *22 May 193910 Mar 1942Arthur E SmithContainer closure
US2524366 *24 Ene 19483 Oct 1950Arthur E SmithReceptacle closure
US2524607 *24 Ene 19483 Oct 1950Arthur E SmithContainer closure device
Citada por
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US2738890 *3 Abr 195320 Mar 1956Harold C DahlDevices for holding articles in a refrigerator container
US2764983 *20 Mar 19532 Oct 1956Corwin Hinshaw HortonDual compartment mixing vial
US2807384 *12 Mar 195624 Sep 1957Lipari MichaelCompartmental dispensing receptacle
US2908418 *28 May 195613 Oct 1959Frame SaClosure device and process for the manufacture thereof
US2974785 *8 Jul 195714 Mar 1961Griffon HenriContainer for the separate storage and extemporaneous mixing of constituents in injectable solution
US3357545 *1 Nov 196512 Dic 1967Koberly IncDental materials and apparatus for preparing the same
US3439823 *27 Nov 196722 Abr 1969OrealContainer stopper comprising a hollow capsule
US3603484 *28 Feb 19697 Sep 1971Mix O Matic CorpA two-compartment mixing and dispensing device
US3638918 *9 Mar 19701 Feb 1972Dental Design SystemsMixing of substances
US3779372 *28 Mar 197218 Dic 1973De Lloret HContainer for the components of mixed drinks
US4103772 *3 Sep 19761 Ago 1978Georg WiegnerSealed container with frangible partition
US4121772 *17 Ago 197724 Oct 1978Rubin MandrellPortable spray can for dual liquids
US4174035 *13 Jul 197813 Nov 1979Georg WiegnerTwo-component container and package
US4465471 *26 Jul 198214 Ago 1984Eli Lilly And CompanyIntravenous administration system for dry medicine
US4550825 *27 Jul 19835 Nov 1985The West CompanyMulticompartment medicament container
US4657534 *4 Nov 198514 Abr 1987Alcon Laboratories, Inc.Dual compartment, disposable, mixing and dispensing container
US5035320 *7 May 199030 Jul 1991Clifford PloneDispenser system with elongated selectively activatable dispensing pusher
US5147337 *22 Jul 199115 Sep 1992Clifford PloneMedicament dispenser
US5804213 *15 Jul 19928 Sep 1998Lectec CorporationPrepackaged; poured as liquid, sets as elastic solid
US6189688 *30 Ene 199820 Feb 2001BiodomeMulti-chamber dispensing container for storing at least two substances, the extemporaneous mixture of these substances, and distribution of the mixture
US640671225 Oct 199418 Jun 2002Lectec CorporationWound healing agents and bandages with hydrocolloid gel polymers
US66015776 Abr 20015 Ago 2003Moshe BouskilaContainer assembly for warming beverages and method of forming and using it
US7874420 *9 Feb 200925 Ene 2011Darren CoonAffixable dispensing capsule
US8714808 *22 Ago 20056 May 2014Yoshino Kogyosho Co., Ltd.Container for mixing two fluids
WO2004000678A1 *20 Jun 200331 Dic 2003Mark C BagleyMixing vial
Clasificaciones
Clasificación de EE.UU.206/222, 206/219, 604/416, 215/DIG.800
Clasificación internacionalB65D51/28
Clasificación cooperativaB65D51/2842, Y10S215/08
Clasificación europeaB65D51/28B1C