US2671451A - Remedial pill - Google Patents

Remedial pill Download PDF

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Publication number
US2671451A
US2671451A US293731A US29373152A US2671451A US 2671451 A US2671451 A US 2671451A US 293731 A US293731 A US 293731A US 29373152 A US29373152 A US 29373152A US 2671451 A US2671451 A US 2671451A
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pill
remedial
substance
magnetically attractable
ulcer
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US293731A
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Stephen J Bolger
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting

Definitions

  • the present invention relates to remedies and more particularly to pill-type remedies and a method of treating internal disorders.
  • the objects of this invention are, therefore, to provide an efiicacious method of treating such localized internal disorders, and more specifically to provide a special type of pill to be used in connection with the method.
  • Figure 1 is a front view of a human torso showing parts of the alimentary canal in cutaway view
  • Figure 2 is a similar view of a human torso showing parts of the alimentary canal in dotted lines and illustrating the first step in practicing my new method
  • Figure 3 is a cutaway view of a part of the alimentary canal showing the esophagus, the stomach, the pylorus and the duodenum, which view illustrates another step in the practice of my new method;
  • Figure 4 is a central sectional view through a spherical pill made according to the invention.
  • Figure 5 is a. perspective view of a lozenge or tablet form of the pill.
  • Figures 1 and 2 show the human torso generally designated l and parts of the alimentary canal comprising the esophagus II, the stomach l2, and the intestines which are generally designated I3.
  • a powerful magnet l6 (see Figure 2) here shown as a bar magnet secured Cir in position as by means of adhesive tape II. It will be understood that any other form of magnet such as an electromagnet might be used in place of the magnet IB.
  • a special pill generally designated 18 in Figure 3.
  • This special pill forms a part of my invention, and comprises a body of the prescribed remedial substance having a, magnetically attractable metallic element associated therewith.
  • the pill illustrated in Figure 4 is of spherical form, having a body 19 of the remedial substance and a spherical core 28 of iron or other magnetically attractable metal.
  • the pill shown in Figure 5 is similar, comprising a lozenge-type body 2
  • the pill When the pill has passed through the alimentary canal to a point at or near the ulcer IE, it is halted in its passage by the magnet "S, whereupon the pill slowly dissolves in the immediate vicinity of the ulcer with beneficial efiects thereon. When the pill has completely dissolved the magnet IB is removed from the patient's body and the metallic core of the pill passes harmlessly therethrough.
  • a remedial pill comprising a remedial substance which is soluble in the human body and a. magnetically attractable metallic element associated with said substance.
  • a remedial pill having a core of magnetically attractable metal encased in a remedial substance which is soluble in the human body.
  • a spherical remedial pill having a spherical core of magnetically attractable metal.

Description

5. J. BOLGER REMEDIAL PILL March 9, 1954 Filed June 16, 1952 INVENTOR fiephen' JLBO {9 mauw ATTORNEY Patented Mar. 9, 1954 UNITED STATES PATENT OFFICE 3 Claims.
The present invention relates to remedies and more particularly to pill-type remedies and a method of treating internal disorders.
In localized disorders of the alimentary canal, particularly ulcers, it is very diflicult to apply a remedy to the affected spot for the reason that there is a constant flow through the canal caused by the normal digestive processes. Any remedy in the form of a tablet or pill is therefore quickly washed past the affected spot and consequently has very little or no remedial efiect. There are known remedies which, if they could be made to stop at or near the affected spot, would slowly dissolve, with a highly beneficial effect.
The objects of this invention are, therefore, to provide an efiicacious method of treating such localized internal disorders, and more specifically to provide a special type of pill to be used in connection with the method.
Illustrative embodiments of the invention are shown in the accompanying drawing, wherein:
Figure 1 is a front view of a human torso showing parts of the alimentary canal in cutaway view;
Figure 2 is a similar view of a human torso showing parts of the alimentary canal in dotted lines and illustrating the first step in practicing my new method;
Figure 3 is a cutaway view of a part of the alimentary canal showing the esophagus, the stomach, the pylorus and the duodenum, which view illustrates another step in the practice of my new method;
Figure 4 is a central sectional view through a spherical pill made according to the invention; and
Figure 5 is a. perspective view of a lozenge or tablet form of the pill.
Referring now in detail to these drawings, Figures 1 and 2 show the human torso generally designated l and parts of the alimentary canal comprising the esophagus II, the stomach l2, and the intestines which are generally designated I3.
Any part of the alimentary canal might be locally affected as by an ulcer, and if so afiected could be treated according to my new method. However for the purpose oi illustration I have shown in Figure 3 the pylorus ll affected by an ulcer I 5.
In treating the ulcer according to my method, I first apply to the exterior of the human torso nearest the ulcer a powerful magnet l6 (see Figure 2) here shown as a bar magnet secured Cir in position as by means of adhesive tape II. It will be understood that any other form of magnet such as an electromagnet might be used in place of the magnet IB. Next I administer to the patient, who is preferably in a reclining position, a special pill generally designated 18 in Figure 3. This special pill forms a part of my invention, and comprises a body of the prescribed remedial substance having a, magnetically attractable metallic element associated therewith. The pill illustrated in Figure 4 is of spherical form, having a body 19 of the remedial substance and a spherical core 28 of iron or other magnetically attractable metal. The pill shown in Figure 5 is similar, comprising a lozenge-type body 2| of the remedial substance and a core 22 of magnetically attractable metal.
When the pill has passed through the alimentary canal to a point at or near the ulcer IE, it is halted in its passage by the magnet "S, whereupon the pill slowly dissolves in the immediate vicinity of the ulcer with beneficial efiects thereon. When the pill has completely dissolved the magnet IB is removed from the patient's body and the metallic core of the pill passes harmlessly therethrough.
While I have described but one application of my invention, and indicated others, it will be understood that the method and the form of pill might find numerous other applications falllng within the scope of the following claims.
I claim:
1. A remedial pill comprising a remedial substance which is soluble in the human body and a. magnetically attractable metallic element associated with said substance.
2. A remedial pill having a core of magnetically attractable metal encased in a remedial substance which is soluble in the human body.
3. A spherical remedial pill having a spherical core of magnetically attractable metal.
STEPHEN J. BOLGER.
References Cited in the file of this patent UNITED STATES PATENTS Number Name Date 1,505,209 Leach et al Aug. 19, 1924 2,483,098 Millard Sept. 27, 1949 2,518,758 Cook Aug. 15, 1950 FOREIGN PATENTS Number Country Date 485,378 Great Britain May 18, 1938

Claims (1)

1. A REMEDIAL PILL COMPRISING A REMEDIAL SUBSTANCE WHICH IS SOLUBLE IN THE HUMAN BODY AND A MAGNETICALLY ATTRACTABLE METALLIC ELEMENT ASSOCIATED WITH SAID SUBSTANCE.
US293731A 1952-06-16 1952-06-16 Remedial pill Expired - Lifetime US2671451A (en)

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Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863458A (en) * 1957-09-04 1958-12-09 Michael T Modny Vein stripper and a method of stripping veins
US2921584A (en) * 1954-12-17 1960-01-19 Honeywell Regulator Co Vessel occluder
US2971916A (en) * 1957-01-30 1961-02-14 Ncr Co Microscopic capsules containing magnetizable material
US3042616A (en) * 1958-08-26 1962-07-03 Ibm Process of preparing magnetic ink
US3056724A (en) * 1956-11-05 1962-10-02 Commw Scient Ind Res Org Therapeutic pellets for ruminants
US3057344A (en) * 1957-05-21 1962-10-09 Abella Carlos Alberto Capsule for the study of the digestive tract and method of using the same
US3118439A (en) * 1957-04-09 1964-01-21 Perrenoud Jean-Pierre Diagnostic and medicating capsule and the method of use
US3146169A (en) * 1960-01-21 1964-08-25 Burroughs Wellcome Co Pharmaceutical formulations and their manufacture
US3421210A (en) * 1964-08-05 1969-01-14 Nitroglycerin Ab Method for the manufacture of the fuse head element of electric fuses
US3474777A (en) * 1966-02-10 1969-10-28 Amp Inc Method of administering therapeutic agents
US3592185A (en) * 1967-04-18 1971-07-13 Yeda Res & Dev Ferromagnetic contrast media and method of use
US3608549A (en) * 1970-01-15 1971-09-28 Merrill Edward Wilson Method of administering drugs and capsule therefor
US4030499A (en) * 1974-12-30 1977-06-21 Louis Bucalo Method and apparatus for providing living beings with absorbable implants
EP0000667A1 (en) * 1977-08-01 1979-02-07 Northwestern University Intravascularly-administrable, magnetically-localizable biodegradable carrier and process for its preparation
US4162679A (en) * 1976-09-28 1979-07-31 Reenstierna Erik G B Method and device for the implantation of one or more pacemaker electrodes in a heart
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
EP0042249A2 (en) 1980-06-13 1981-12-23 Northwestern University Magnetically-localizable, biodegradable lipid microspheres
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US4878905A (en) * 1986-02-07 1989-11-07 Blass Karl G Gastrointestinal module: a nonsurgical implant
EP0409893A1 (en) * 1988-04-01 1991-01-30 FISCHMAN, Walter Whitson Magnetically influenced homeopathic pharmaceutical formulations and methods of their preparation
US5079006A (en) * 1987-07-15 1992-01-07 Aprex Corporation Pharmaceutical compositions containing a magnetically detectable material
US5162037A (en) * 1988-04-01 1992-11-10 Whitson Laboratories, Inc. Magnetically influenced homeopathic pharmaceutical formulations, methods of their preparation and methods of their administration
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5443841A (en) * 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5529568A (en) * 1994-03-18 1996-06-25 Surgery Futures Research, Inc. Magnetic operating table
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5578323A (en) * 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5643957A (en) * 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5667806A (en) * 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5693338A (en) * 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5709861A (en) * 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5714167A (en) * 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5766633A (en) * 1993-04-22 1998-06-16 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
USRE35862E (en) * 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
US5792451A (en) * 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5804688A (en) * 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5811127A (en) * 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5820881A (en) * 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5863944A (en) * 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) * 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) * 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5879681A (en) * 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5939381A (en) * 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5962710A (en) * 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) * 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) * 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) * 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6051258A (en) * 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US6060513A (en) * 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6071510A (en) * 1995-03-31 2000-06-06 Emisphere Technologies, Inc. Modified amino acids and compositions comprising the same for delivering active agents
US6084112A (en) * 1995-09-11 2000-07-04 Emisphere Technologies, Inc. Method for preparing ω-aminoalkanoic acid derivatives from cycloalkanones
US6090958A (en) * 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6099856A (en) * 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US6242495B1 (en) 1997-02-07 2001-06-05 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US6375983B1 (en) 1996-06-14 2002-04-23 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US20050186176A1 (en) * 1996-03-29 2005-08-25 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20060134130A1 (en) * 1993-04-22 2006-06-22 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US20060166859A1 (en) * 1997-02-07 2006-07-27 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20080171907A1 (en) * 2007-01-12 2008-07-17 Ethicon Endo-Surgery, Inc. Magnetic Tissue Grasping

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US1505209A (en) * 1922-05-12 1924-08-19 Francis I Leach Radium-carrying device
GB485378A (en) * 1936-11-18 1938-05-18 Johan Van Roojen Improvements in and relating to appliances for medical treatment with radiations from radio-active elements
US2483098A (en) * 1946-01-09 1949-09-27 Everett L Millard Supplying agents to the digestive tract
US2518758A (en) * 1949-06-22 1950-08-15 George B Cook Magnetic stirring apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1505209A (en) * 1922-05-12 1924-08-19 Francis I Leach Radium-carrying device
GB485378A (en) * 1936-11-18 1938-05-18 Johan Van Roojen Improvements in and relating to appliances for medical treatment with radiations from radio-active elements
US2483098A (en) * 1946-01-09 1949-09-27 Everett L Millard Supplying agents to the digestive tract
US2518758A (en) * 1949-06-22 1950-08-15 George B Cook Magnetic stirring apparatus

Cited By (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2921584A (en) * 1954-12-17 1960-01-19 Honeywell Regulator Co Vessel occluder
US3056724A (en) * 1956-11-05 1962-10-02 Commw Scient Ind Res Org Therapeutic pellets for ruminants
US2971916A (en) * 1957-01-30 1961-02-14 Ncr Co Microscopic capsules containing magnetizable material
US3118439A (en) * 1957-04-09 1964-01-21 Perrenoud Jean-Pierre Diagnostic and medicating capsule and the method of use
US3057344A (en) * 1957-05-21 1962-10-09 Abella Carlos Alberto Capsule for the study of the digestive tract and method of using the same
US2863458A (en) * 1957-09-04 1958-12-09 Michael T Modny Vein stripper and a method of stripping veins
US3042616A (en) * 1958-08-26 1962-07-03 Ibm Process of preparing magnetic ink
US3146169A (en) * 1960-01-21 1964-08-25 Burroughs Wellcome Co Pharmaceutical formulations and their manufacture
US3421210A (en) * 1964-08-05 1969-01-14 Nitroglycerin Ab Method for the manufacture of the fuse head element of electric fuses
US3474777A (en) * 1966-02-10 1969-10-28 Amp Inc Method of administering therapeutic agents
US3592185A (en) * 1967-04-18 1971-07-13 Yeda Res & Dev Ferromagnetic contrast media and method of use
US3608549A (en) * 1970-01-15 1971-09-28 Merrill Edward Wilson Method of administering drugs and capsule therefor
US4030499A (en) * 1974-12-30 1977-06-21 Louis Bucalo Method and apparatus for providing living beings with absorbable implants
US4162679A (en) * 1976-09-28 1979-07-31 Reenstierna Erik G B Method and device for the implantation of one or more pacemaker electrodes in a heart
EP0000667A1 (en) * 1977-08-01 1979-02-07 Northwestern University Intravascularly-administrable, magnetically-localizable biodegradable carrier and process for its preparation
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
EP0042249A2 (en) 1980-06-13 1981-12-23 Northwestern University Magnetically-localizable, biodegradable lipid microspheres
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4878905A (en) * 1986-02-07 1989-11-07 Blass Karl G Gastrointestinal module: a nonsurgical implant
USRE35862E (en) * 1986-08-18 1998-07-28 Emisphere Technologies, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
US5079006A (en) * 1987-07-15 1992-01-07 Aprex Corporation Pharmaceutical compositions containing a magnetically detectable material
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
EP0409893A1 (en) * 1988-04-01 1991-01-30 FISCHMAN, Walter Whitson Magnetically influenced homeopathic pharmaceutical formulations and methods of their preparation
EP0409893A4 (en) * 1988-04-01 1991-03-13 Walter Whitson Fischman Magnetically influenced homeopathic pharmaceutical formulations, methods of their preparation and methods of their administration
US5162037A (en) * 1988-04-01 1992-11-10 Whitson Laboratories, Inc. Magnetically influenced homeopathic pharmaceutical formulations, methods of their preparation and methods of their administration
US6348207B1 (en) 1992-06-15 2002-02-19 Emisiphere Technologies, Inc. Orally deliverable supramolecular complex
US6245359B1 (en) 1992-06-15 2001-06-12 Emisphere Technologies, Inc. Active agent transport systems
US6071538A (en) * 1992-06-15 2000-06-06 Emisphere Technologies, Inc. Oral delivery composition comprising supramolecular complex
US6099856A (en) * 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5714167A (en) * 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) * 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US6413550B1 (en) 1992-06-15 2002-07-02 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5601846A (en) * 1992-06-15 1997-02-11 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5443841A (en) * 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US5840340A (en) * 1992-06-15 1998-11-24 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5811127A (en) * 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5401516A (en) * 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5972387A (en) * 1992-12-21 1999-10-26 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5540939A (en) * 1992-12-21 1996-07-30 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5643957A (en) * 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) * 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6100298A (en) * 1993-04-22 2000-08-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20060134130A1 (en) * 1993-04-22 2006-06-22 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5955503A (en) * 1993-04-22 1999-09-21 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5766633A (en) * 1993-04-22 1998-06-16 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5792451A (en) * 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5529568A (en) * 1994-03-18 1996-06-25 Surgery Futures Research, Inc. Magnetic operating table
US5593379A (en) * 1994-03-18 1997-01-14 Surgery Futures Research, Inc. Magnetic operating table
EP0773005A1 (en) 1994-03-18 1997-05-14 Surgery Futures Research Inc. Magnetic operation table
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6180140B1 (en) 1994-04-22 2001-01-30 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5976569A (en) * 1994-09-29 1999-11-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5693338A (en) * 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5866536A (en) * 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) * 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6346242B1 (en) 1995-03-31 2002-02-12 Emishpere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) * 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US6071510A (en) * 1995-03-31 2000-06-06 Emisphere Technologies, Inc. Modified amino acids and compositions comprising the same for delivering active agents
US5989539A (en) * 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) * 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) * 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6428780B2 (en) 1995-03-31 2002-08-06 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) * 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5667806A (en) * 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US6100285A (en) * 1995-06-07 2000-08-08 Emisphere Technologies, Inc. Method of solubilizing itraconazole
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US6051258A (en) * 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
US6461545B1 (en) 1995-06-07 2002-10-08 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
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