Búsqueda Imágenes Maps Play YouTube Noticias Gmail Drive Más »
Iniciar sesión
Usuarios de lectores de pantalla: deben hacer clic en este enlace para utilizar el modo de accesibilidad. Este modo tiene las mismas funciones esenciales pero funciona mejor con el lector.


  1. Búsqueda avanzada de patentes
Número de publicaciónUS2818852 A
Tipo de publicaciónConcesión
Fecha de publicación7 Ene 1958
Fecha de presentación27 Jun 1956
Fecha de prioridad27 Jun 1956
Número de publicaciónUS 2818852 A, US 2818852A, US-A-2818852, US2818852 A, US2818852A
InventoresKugler Heinz W
Cesionario originalKugler Heinz W
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Spring-pressed surgical instrument
US 2818852 A
Resumen  disponible en
Previous page
Next page
Reclamaciones  disponible en
Descripción  (El texto procesado por OCR puede contener errores)

Jan. 7, 1958 Filed June 27, 1956 I H. W. KUGLER SPRING-PRESSED SURGICAL INSTRUMENT JI-l 2 Sheets-Sheet 1 MII Il I* INVENTOR.

v i l #62.72 14./ Aigle? Jan. 7, 198 H. w. KUGLER 2,818,852

v SPRING-PRESS@ SURGICAL INSTRUMENT v Filed Jima 27. 195e z sheets-sheet 2 INVENTOR.

IY'Z Heinz li( /Tzgler n BY f Y @7mm/m SPRlNG-PRESSED SURGICAL INSTRUMENT Heinz. W. Kugler, College Park, Md., assigner to the United States of America as represented by the Secretary of the Army Application June 27, 1956, Serial No. 594,331

6 Claims. (Cl. 12S-2) (Granted under Title 35, U. S. Code (1952), sec. 266) The invention described herein may be manufactured and used by or for the Government for governmental purposes without the payment of any royalty thereon.

The present invention provides improvements in surgical instruments employed for obtaining specimens of live skin or tissue for biopsy examination, or other physiological specimens for microscopic and/or histologic examination for diagnostic purposes or for other studies; or for obtaining samples of other soft materials such as paper, cloth, felt or the like.

More particularly, the invention provides improvements in the construction of a mechanically operated punch for obtaining specimens or samples of the aboveindicated character.

The present improved instrument is designed to be hght in weight `and freely portable, and to be operable wholly mechanically instead of utilizing electrical power as is required by existing equipment employed for similar purpose, thus widely increasing the field or scope of utility of the present equipment.

The usual instruments employed for taking specimens of the herein-indicated character are electrically powered. Such type of electrically powered punch is an ordinary high-speed motor-driven hand tool with the cutter head held by a chuck. For regulating the depth of the cut, there are used transparent Lucite plastic blocks of various thickness provided with a hole slightly larger than the cutter. The Lucite block is placed on the skin, and the cutter is brought down into the hole until the chuck rests on the block when the cutter becomes operative for taking a desired specimen. Where skin or tissue is to be sampled, for biopsy tests or other examination, this customary operation not only is crude and cumbersome, but a very large amount of heat is generated, which causes discomfort to the patient from whom the sample of skin or tissue is being taken.

The objections which have been noted above are obviated by the mechanically-actuated portable instrument provided by the present invention, the improved construction producing a requisite number of revolutions of a cutting tool sufficient to cut the skin and tissues cleanly without generating uncomfortable heat, or without causing other untoward discomfort to la patient whose skin or tissues are being sampled.

Objects and advantages of the subject invention will become apparent as the description proceeds, and the features of novelty will be pointed out in particularity in the appended claims.

Briely stated, the subject invention embodies a cutting element mounted in a chuck carried by the lower end ot' a driving spindle rotatably housed within an elongated cylindrical barrel casing or handle member. The spindle is encircled by a helical spring attached at its lower end to the barrel and at its upper end to a slip-ring or freewheelingcoupling device keyed to the spindle, but incorporating means for allowing independent rotation of the latter after an initial turning movementhas been irnparted to the free-wheeling coupling by the energy stored Patented Jan. 7, 1958 in the spring. A rotatable cap is mounted on the upper end of the casing and connected to the driving spindle through the instrumentality of a pawl and ratchet mechanism to effect winding of the spring upon rotation of the cap. Energy stored by the spring is released by a manually-controlled depressible member in the cap, which separates the pawl and ratchet mechanism to permit the spring to impart a turning movement and sufcient inertia to the spindle to give it a spinning movement of about 30 to 50 rotations more than the free-wheeling coupling.

This improved construction of the subject invention will be understood more clearly from reference to the accompanying drawings, in which:

Fig. l is an elevation of an illustrative embodiment of the improved construction;

Fig. 2 is a Vertical section of the instrument oi Fig. l, the view being taken on the longitudinal or vertical axis of the instrument along the line iI-ll of Fig. l;

Fig. 3 is a view similar to Fig. 2, but showing the cutter in operative or specimen-cutting position; and

Figs. 4, 5, 6, 7 and 8 are transverse sectional views taken on the section lines IV-IV, V-V, VI-VI, VII- VIL and VIII-VH1 of Fig. 2, respectively, looking in the direction of the arrows in each view.

Referring more particularly to the drawings, the respective views show details of an illustrative embodiment of a suitable instrument for obtaining skin or tissue specimens for biopsies, histological examinations, or for other studies, from which views it will be seen that the instrument comprises three principal sections, namely, a bottom or chuck section A, an intermediate or stationary barrel or handle section B, and an operating cap section C. Structural details of each section will be referred to hereinafter.

The stationary barrel or handle section B comprises a tubular cylindrical casing l0, having a knurled outer surface 12, containing a rotatable driving spindle 14. The spindle 14 terminates in opposite end sections then being shown and a top stem portion 16 and a bottom end stem portion 19 having a locking chuck 18 mounted on this lower stem portion T19. ri`he chuck 13 releasably receives a specimen cutting 'tool 20 of a suitable shape and size for cutting out slain and tissue specimens for microscopic or other testing or examination procedures.

The spindle ld is enclosed in a helical spring 22, one end of which, such as the lower end 24, is secured to the casing 10, while an opposite end of the spring, that is, its upper end 26, is secured in a slip ring or'free-wheeling coupling device 2S, which is connected to the spindle 14 by a key or other connection. The free-Wheeling coupling 2S will be referred to further hereinafter; and it incorporates means for allowing independent rotation of the latter alter an initial turning movement which has been imparted to the free-wheeling coupling 2S by energy stored in spring 22.

The spring Z2 `obviously is the operating means or source of power for the instrument. With further reference to this spring and its connection to the casing 1?,

it will be seen that such connection includes a screw plug 3i) threadedly mounted in the casing 10 adjacent to the lower end thereof, this plug 3) having an opening 31 which receives the lower end 24 of the spring, the plug 30 also including a threaded hole 33 which receives a locking screw 32 which lockingly engages the end 24 of the spring 22 and secures the spring in place in opening 31.

ln a similar manner, the opposite, or upper, end of the spring, which is indicated `at 26, is received in slip ring or free-Wheeling coupling device 28, which is provided With lopening 34 into which the end portion 26 of the spring 22 is itted and locked by locking screw 36. The free-wheeling coupling 28 is an annulus which is mounted on the upper end of the spindle 14, the opening 38in the said coupling28 receivingrthe spindle.14.in eccentric relation with the latter, .as is `indicated :at 4.0, Fig. 6, there beingan abutment shoulder 42 againstwhich engages anfoutwardly directed locking pawl 44, .which is mountedin a recessi 46 in the spindle 14, the pawl 44 being urged. outwardly with respect to the spindle 14 and against the inner periphery of the free-wheeling coupling 28 by action of a compression spring 48 which is mounted in an axial recess 50 in-locking pawl 44, the spring v48 being 4compressed between the locking pawl 44 yand the inner end 52 of the recess 46 in spindle 14.

The .foregoing mounting ofthe .spring 14 permits an interlocked .engagement between the pawly 44 with abutment shoulder 42 during counterclockwise rotation of spindle 14, as indicated by the directional arrow on Fig. 6, for tensioning spring 22 as the spring is wound up, while enabling the free-wheeling coupling 28 andspindle 14 to be Ireleased for clockwise 4rotation to release the tension in the spring for outward propulsion of the cutting tool 20 from the chuck section A of the instrument.

Referring further to the structure of the spindley 14 and to the structural details of cap section C, it will be noted that thespindle 14 is provided with an upper flange collar 54 for retaining the free-wheeling eoupling'28 on the spindle 14, the'top restricted stern '16.extending upwardly from the ange collar 54, there being a stop 56 on the flange collar 54, which stop 56 engages the underside of an anti-friction bearing 58'which'is mounted in a top yclosure plug 60 that is threadedly mounted in the top end of casing 10. The closure plug 60is provided with a retaining ange or collar 62, against the .underside of which an annular locking collar or ring 64 is maintained in assembled relation by yspaced screws 66 which extend through the ring 64 into lthe underside of operating cap 68 of the cap section C of the instrument, thereby clamping the annular ange 62'between the ring 6.4 and cap 68.

The ange `62 divides the outside of the plug 60 into two sections, that is, a lower externallyfthreaded section 61, the threads of which register with complemental threads in the top of cylindrical casing .10, and an upper section 63. The lower section 61 houses the anti-friction bearing 5,8, the inner race of which is in engagement with the lower portions of stem 16 of the spindle 14. IIl'he upper section 63 `of the plug 60 is provided with a `large recess which communicates with lower recess 67 containing the anti-friction lbearing 58 throughgopening 169.

which forms ange 71 against which the top of antifriction bearing 58 abuts. l

'Ihe operating cap 68 is provided with a knurledV outer surface which is provided with interiorly threaded openings for receiving threaded internally recessed plugs 72 .and 74, having internal recesses 75 and 77 in which pawl `elements 76 and 78 are slidably mounted and in which compression coil springs 80 and 82 are received and held between the respective pawl `elements 76 and 78 and the closed ends of recesses 75 and 77, the Ipressure of the springs against the pawl elements continuously urgingthe latter outwardly with respectto thel plugs 72 and 74.

The upper section 63 of ythe plug 60 has its outer surface formed with peripheral locking teeth 84 which extend the height of the upper section 63 of the plugand-which are engaged by lpawl element 76 for lockingly interconnecting the top section 63 of the plug 60 with the cap68 when the latter is urged in counterclockwise d-irection as will be seen in Fig. 5, 'and which will be referred to again hereinafter.

Cap 468 is recessed appropriatelyy interiorly to receive the top section 63 of plug 60,. and also torhouse ratchet member 92,"the teeth 94 of which interlockinglyengage with'pawl 78 Yfor interlocking the'stem '16 of spindle '14 to the cap 68 when the latter is being urged in clockwise direction, but releases the stem 16 for rotation relative to the cap 68 when the latter is being urged in counterclockwise direction as shown in Fig. 4, so that the teeth 94 of ratchet 92 are pitched in yopposite direction to teeth 84 on the upper, or docking, section of plug 60. The .ratchet Y92 has -al vlower hub portion 93 having an opening 91 therethrough for receiving locking screw 90 which-locksratchet'92 tothe stemv 16l of spindle 14. The teeth 94-of ratchet^92 are engaged by pawl" 78 which continuously is urged against the teeth"94 by pressure of spring 82, .thefouterend of the pawl ,'78 being beveled to conform to the slope of teeth 94.

The upper end'of stem portion 16 of spindle 14 is received inra release push cap 96 which is mounted in a top opening 98 in the cap 68. The release push cap 96has a ,retaining flange y100 which is larger in diameter than the top lopening 98, and it also has an axially extending recesskllwhich tightly receivesthe upper end of stem 16,'an .anti-frictionbearing 102 being provided between the upper end of the stem and the closed end 104 of the recess 1.0.1.

As has been noted. above, the lower end of spindle 14 is extended .into lower .stem section 19, which is encircled by a bottom anti-friction bearing 106 which is retained betweenthreaded restricted end 108 of the barrel 10 and the lower stem section 19. of .the spindle. The stem 19 is provided with a,longitudinally-extending axial recess 110 into which is iittedshank .112 .of cutting device or tool 20 which is releasably locked in place by a lchuck 18. Adjustable gage sleeve, 114, having knurled surface portion 116 and locknut .117 having a knurled surface 118 are threadedly mounted on restricted end 108 .of the casing 10, the sleeve 114 being provided with a lateral sight opening 120 andend opening 122 for passage ofspecimen cutting tool 20. The adjustable gage sleeve 114is locked in adjusted position by the knurled lock nut 117, which is threadedly mounted on restricted end 108 of :casing 10, above the gage sleeve .114.

lln .operation,a cutting. tool 20 ofdesired size, is inserted in chuck 18 and-the depth of cut is set by .pushing the thumb release .cap 96.down andturning the depth gage sleeve 114 upordown until theV cutting tool 20 is protruding for the desired distance, and locking the sleeve 114 into .position with lthe lock nut 117. The punch is wound in a vertical position with the cutter 20 lupwards to permit the spindle 14.tobe in loadedposition. The barrel 10 of the tool is held in the left hand and the cap C is rotated counterclockwise approximately three revolutions. When winding, ratchet 92- turns top stem portion 16, and'therefore spindle 14, which turns slip ring 28, which winds the spring 22. The ratchet 63 prevents the spindle 14 from unwinding. As` has been noted above, theAspring-ZZ is secured to the casing 10, shown in Fig. 7, and to' the vslip ring'f28 as shown in Fig. 6. This slip ring 28 permits the spring V22 to be wound. When the punch is releasedthe` spring 22 unwinds its three revolutions but permits thel spindle 14to travel approximately 30 to 50 revolutions. In'Fig. 4, pawl 78 slides throughl a square hole'77, which prevents thepawl 78 from turning.

To release the punch, the thumb release cap 96 is Ypushed downwardly. `In sodoing, .the punch does not operate until the. ratchet 'wheel 92 slides olf the ratchet stop pawl 78. At this moment, the cutting tool 20 is in close contact with the live skin, and as the spindle V14 is released, the cutting tool 20 While revolving is brought downto the full predetermined-depth ofthe cut, thus completing the operation. .The ball 102 -in the thumb release cap `96 is provided to reduce friction, as are the two ball bearings 58 and 106. `Ratchet '63, having alefthand thread, will tighten as the spring, pressure in winding is increased. The cap sectionC is set into position and the retaining ring 64 isfastened' to thebottom of section C with eight (more or less) small screws 66. The ratchet wheel'92 in Fig. 4 is held in position by set screw 90 which prevents slipping,

although other means may be used to obtain the same result. Opening 120 in the depth-gauge 114 is provided for viewing and centering the cutting tool 20 over the area to be sampled.

After cutting, the tool is removed from the skin surface and the plug of skin is removed from the subject by means of suitable surgical instruments at the base of the plug. Plugs of other materials may remain in the cutter and are subsequently removed.

The embodiment of the invention illustrated in the accompanying drawings and described specifically in the foregoing description is illustrative of a representative example of the present invention, but it will be apparent that specific structural details may be varied without departing from the inventive concept; and accordingly, it will be understood that it is intended and desired to embrace within the scope of the invention such modifications and changes as may be necessary or desired to adapt it to varying conditions and uses as defined by the appended claims.

Having thus described my invention, what I claim as new and wish to secure by Letters Patent is:

1. A manually operable surgical cutting device for obtaining specimens of skin and tissue for microscopic examinations, which comprises in combination, a tubular barrel-handle member having, when in operative position, an upper end and a lower end, a rotatable spindle housed in the barrel member and having a pair of oppositely directed stem portions, one of which is an upper stem portion projecting beyond the upper end of the barrel, the other of which stem portions is a bottom stem portion projecting beyond the lower end of the barrel, a free-wheeling coupling element in the barrel adjacent to its upper end, a coil spring encircling the spindle and having a lower end secured to the barrel and an upper end secured to the freewheeling coupling element, locking means releasably connecting the spindle to the free-wheeling coupling element for applying increasing tension to the coil spring responsively to actuation of the free-Wheeling coupling in one direction, a tissue-cutting tool carried by the bottom stem portion of the spindle, increasing tension in the coil spring withdrawing the spindle and cutting tool into the barrelhandle member, and a top closure cap assembly for closing the upper end of the barrel member including fingerrelease mechanism for releasing the resulting tensioned coil spring for reversely actuating the spindle to impact the tissue-cutting tool against an anatomical surface for enabling the tool to cut a specimen of Skin and tissue to be examined.

2. The cutting device claimed in claim 1, wherein the top closure cap assembly includes a closure plug threadedly mounted in the upper end of the barrel having the upper stem portion of the spindle extending therethrough, a hollow closure cap secured to the plug, the said plug having external intermediate ratchet teeth on outer portions thereof adapted to interlock releasably with an intermediate pawl member mounted in the closure cap connecting the closure cap and plug, a top ratchet member mounted on the said stem portion of the spindle, a second locking pawl in the closure cap for locking with the top ratchet, and a manually depressible operating cap mounted in the closure cap over the upper stem of the spindle for depressing the latter until the ratchets become released from their coacting pawls for causing the spring to rotate the spindle and cutting tool for operating the latter.

3. A manually operable surgical cutting device comprising a tubular handle casing, a rotatable spindle mounted in the casing for oppositely directional rotation with respect to the casing, a cutting tool carried by the spindle, spring driving means connected to the casing and enclosing the spindle, a rotatable cap on the casing, the spring being also secured to the cap for enabling the spring to be wound into tensioned condition, latch means for holding the spring under tension, spring releasing mechanism mounted on the casing, and energy-transmitting coupling means eccentrically connected to the spring and unidirectionally rotatably keyed to the spindle enabling the spring to rotate the spindle for operating the cutting tool and enabling the spindle to decelerate at a slower rate than the spring and coupling means.

4. A manually operable surgical cutting device comprising, in combination, a tubular casing defining a handle for the device, a rotatable spindle mounted in the casing, a releasable chuck on a lower end of the spindle an interchangeable cutting tool held by the chuck, a helical spring encircling the spindle, one end of the spring being affixed to the casing `and an opposite end of the spring being operably connected to the spindle, a rotatable cap on the casing, a pair of pawls extending into the cap, a pair of oppositely-directed ratchets adacent to and engaged by the pawls, one of the ratchets being connected to the spindle and enabling the spring to be increasingly tensioned responsively to rotating the cap in a given direction, the other of the pair of ratchets being connected to the casing for holding the spring in tensioned condition, manually operable mechanism for releasing the tensioned spring, and a free-wheeling slip-ring coupling unidirectionally rotatably keyed to the spindle and eccentrically connected to the spring for rotating the spindle and enabling the spindle to decelerate at a slower rate than the coupling.

5. The structure defined in claim 4 comprising additionally an adjustable shoulder on the cutting tool end of the casing.

6. The device of claim 3 further including releasable latch means between the casing and spindle for securing the spindle between step-wise increases in tension in the spring responsive to continued Winding of the spring.

References Cited in the tile of this patent UNITED STATES PATENTS 1,905,851 Green Apr. 25, 1933 2,249,906 Longoria July 22, 1941 2,419,045 Whittaker Apr. l5, 1947

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US1905851 *30 Abr 193025 Abr 1933Green Louis DSurgical instrument
US2249906 *3 Sep 193822 Jul 1941Ramon CastroviejoSurgical device
US2419045 *4 Ene 194715 Abr 1947Whittaker Charles CSpring-driven rotatable surgical cutter with hand pressure speed control
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US3020912 *6 Oct 195813 Feb 1962Chester Martin HMotor driven surgical knife
US3512519 *26 Oct 196719 May 1970Hall Robert MAnatomical biopsy sampler
US3515128 *11 Dic 19672 Jun 1970Mcevoy Bernard FSkin biopsy punch
US3666028 *25 Sep 197030 May 1972Us NavyCoring apparatus for taking samples of the ocean floor
US3692020 *29 Abr 197119 Sep 1972Schied Robert JRotary punch for excising uniform diopsy specimens
US3776237 *11 May 19724 Dic 1973Tecna CorpSurgical tool and method of providing a surgical opening
US3807405 *13 Ene 197130 Abr 1974B NiebelMole remover
US3815605 *11 May 197211 Jun 1974Philips CorpDevice and holder therefor for inserting a hollow coupling member into bone marrow
US3990453 *28 Feb 19759 Nov 1976Douvas Nicholas GApparatus for cataract surgery
US4494555 *11 Mar 198322 Ene 1985L'orealDisconnectible apparatus comprising a double bayonet coupling
US4605011 *13 Mar 198412 Ago 1986Naeslund Jan IngemarCell sampling apparatus
US4750491 *8 Nov 198414 Jun 1988Allergan, Inc.Trephine and method
US4763651 *14 Ene 198616 Ago 1988Allergan, Inc.Trephine and method
US4832045 *18 Mar 198823 May 1989Goldberger Robert EBiopsy instrument
US5029583 *6 Nov 19899 Jul 1991Personal Diagnostics, Inc.Optical analyzer
US5121751 *16 Mar 199016 Jun 1992Ryder International CorporationInstrument for tissue sampling
US5139508 *20 Nov 199118 Ago 1992L-Vad Technology, Inc.Surgical tool
US5156160 *22 Jun 199020 Oct 1992Bennett Lavon LAdjustable biopsy device capable of controlling tissue sample size collected thereby
US5192294 *6 Jun 19919 Mar 1993Blake Joseph W IiiDisposable vascular punch
US5779647 *7 Jun 199514 Jul 1998Chau; SonnyAutomated biopsy instruments
US5980545 *13 May 19969 Nov 1999United States Surgical CorporationCoring device and method
US640270117 Mar 200011 Jun 2002Fna Concepts, LlcBiopsy needle instrument
US655133414 Dic 200022 Abr 2003Integrated Vascular Interventional Technologies, LcExternally directed anastomosis systems and externally positioned anastomosis fenestra cutting apparatus
US662685030 Mar 199830 Sep 2003Allegiance CorporationAutomated biopsy instruments
US662692131 Oct 200130 Sep 2003Integrated Vascular Interventional Technologies, L.C.Externally positioned anvil apparatus for cutting anastomosis
US668907213 Nov 200110 Feb 2004Leopold S. KaplanBiopsy needle instrument
US674324431 Oct 20011 Jun 2004Integrated Vascular Interventional Technologies, L.C.Soft anvil apparatus for cutting anastomosis fenestra
US72586947 Jun 200421 Ago 2007Origin Medsystems, Inc.Medical punch and surgical procedure
US7744544 *9 Dic 200529 Jun 2010Huot Instruments, LlcDermal incisor
US790141729 Oct 20078 Mar 2011Vital Access CorporationSystems for forming an anastomosis with an anvil and an apparatus having at least one guide
US792273429 Oct 200712 Abr 2011Vital Access CorporationMethods for forming an anastomosis with a vessel having everted tissue
US798112614 Dic 200019 Jul 2011Vital Access CorporationLocking compression plate anastomosis apparatus
US803406415 Mar 200611 Oct 2011Vital Access CorporationMethods for forming an anastomosis opening in a side of a blood vessel
US810994929 Oct 20077 Feb 2012Vital Access CorporationSystems for forming an anastomosis
US92592105 May 201116 Feb 2016Icahn School Of Medicine At Mount SinaiTissue sampling tool
US20010004698 *14 Dic 200021 Jun 2001Blatter Duane D.Locking compression plate anastomosis apparatus
US20040225306 *17 Feb 200411 Nov 2004Blatter Duane D.Paired expandable anastomosis devices
US20060167485 *15 Mar 200627 Jul 2006Blatter Duane DStaple and anvil anastomosis system
US20070135731 *9 Dic 200514 Jun 2007Ward Richard DDermal incisor
US20080045984 *29 Oct 200721 Feb 2008Integrated Vascular Interventional Technologies, L.C.Methods for anastomosing an everted vessel with another vessel
US20080051811 *29 Oct 200728 Feb 2008Integrated Vascular Interventional Technologies, L.C.Systems for anastomosing an everted vessel with another vessel
US20080287972 *29 Oct 200720 Nov 2008Integrated Vascular Interventional Technologies, L.C.Systems for anastomosing an everted vessel with another vessel
US20100022914 *13 Dic 200728 Ene 2010Mark HartSkin Biopsy Devices, Kits Containing Skin Biopsy Device, and Methods of Obtaining a Skin Biopsy
US20130096458 *11 Oct 201218 Abr 2013Stat Medical Devices, Inc.Biopsy punch with safety system and method of making and using the same
DE3612605A1 *15 Abr 198622 Oct 1987Haid Klaus ToniDevice for the production of cut surfaces on nerves of the human or animal body
EP3081170A4 *11 Nov 20149 Ago 2017Univ Madrid Carlos IiiAutomatic device for skin biopsies
WO2011140363A2 *5 May 201110 Nov 2011Mount Sinai School Of MedicineTissue sampling tool
WO2011140363A3 *5 May 201122 Dic 2011Mount Sinai School Of MedicineTissue sampling tool
Clasificación de EE.UU.600/568, 73/864.44, 606/184
Clasificación internacionalA61B10/02, A61B10/00
Clasificación cooperativaA61B10/02
Clasificación europeaA61B10/02