US3149186A - Method for making a catheter - Google Patents

Method for making a catheter Download PDF

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US3149186A
US3149186A US18368562A US3149186A US 3149186 A US3149186 A US 3149186A US 18368562 A US18368562 A US 18368562A US 3149186 A US3149186 A US 3149186A
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Prior art keywords
tubing
pin
catheter
wall
point
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Coanda George
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Don Baxter Inc
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Don Baxter Inc
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Priority claimed from US81808059 external-priority patent/US3064653A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0009—Making of catheters or other medical or surgical tubes
    • A61M25/0015—Making lateral openings in a catheter tube, e.g. holes, slits, ports, piercings of guidewire ports; Methods for processing the holes, e.g. smoothing the edges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/285—Catheters therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/04—Processes
    • Y10T83/0481—Puncturing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T83/00—Cutting
    • Y10T83/283—With means to control or modify temperature of apparatus or work

Definitions

  • Acute renal failure may be caused by infection, transfusion reactions, sulfonamide hypersensitivity, or poisoning. Excessive quantities of bromides, salicyclates, or barbiturates are among the common causes. Although the renal failure may be reversible, it is often diflicult to keep the patient alive until renal function can recover.
  • Peritoneal dialysis has been used in patients having acute renal failure to remove toxic materials from the blood. In this procedure, the peritoneal cavity is filled with a dialyzing solution and the peritoneum serves as a living, semi-permeable membrane. Peritoneal dialysis has not been widely used however, because of certain problems. For example, continuous peritoneal dialysis may cause pooling and channeling of fluid in the abdomen or excessive losses of blood proteins. It also uses relatively large volumes of dialysis fluid and requires a somewhat complicated apparatus. Intermittent peritoneal dialysis has not been widely used because of the difficulty in draining dialysis fluid from the abdominal cavity. Attempts to improve drainage of the fluid by providing the dialysis catheter with larger holes have merely aggravated the problem. Flutes, spiral grooves, and other external catheter shapes designed to shield the catheter holes, in crease irritation of the abdominal tissues and require use of a larger trocar than is desirable.
  • Another object of this invention is to provide a method of making a catheter which will facilitate withdrawal of the dialysis fluid.
  • a further object of the invention is to provide a method of making a peritoneal dialysis catheter having a small outside diameter and a smooth outer surface.
  • FIGURE 1 shows an administration set incorporating a catheter made by this invention
  • FIGURE 2 is a plan'view of the catheter 23 partially cut away at the tip
  • FIGURE 3 is a sectional view on the line 6-6 of FIG- URE 2;
  • FIGURE 4 is a partial enlargement of FIGURE 3.
  • FIGURE 5 is a front elevation, partly in section, of a device for punching the holes in catheter 23.
  • the administration set 10 has two stoppers 15, 16.
  • An inlet tube 11 or 12 is attached to each stopper and is connected, by means of a Y-shaped connector 13, to the flexible administration tube 14.
  • the tube 14 has a metal clamp 17 which, when bent, adjusts or shuts off flow by squeezing the tube 14.
  • the distal end of tube 14 is attached by sleeve 18 to the connecting tube 19, the latter also having a metal clamp 20.
  • a second sleeve 21 connects the distal end of the tube 19 to the proximal end 22 of catheter 23.
  • the catheter 23 is made of an inert, semi-rigid thermoplastic material which will not soften unduly at body temperature.
  • a semirigid tube is defined as a tube which cannot be collapsed by direct hand pressure, which is relatively rigid longitudinally for lengths of one half inch or so, but which is easily bent by hand in lengths of three inches or more. Catheters made from such tubes will not kink or collapse in normal use, out they will bend along their length when necessary so as to minimize trauma.
  • the catheter 23 can be made of nylon, high density polyethylene, Teflon, or Kel-F. Catheter 23 is usually eight to fourteen inches long, has an outside diameter of about 0.1 to 0.2 inch and has a sufiicient wall thickness to make it semi-rigid as defined above.
  • an excellent catheter has been made from a nylon tube having an outside diameter of 0.136 inch.
  • a catheter of this size fits easily within the bore of a 17-French, Duke trocar so that only a small incision is necessary.
  • a Wall thickness of approximately 0.015 inch makes the catheter semi-rigid, while at the same time providing a relatively large inner passage or bore. Such a catheter will bend when it meets an obstruction, but returns to its original shape.
  • the distal end of catheter 23 has a smooth rounded tip 24.
  • a passage or bore 26 passes axially through the catheter 23.
  • the distal portion of catheter 23 is provided with seventy to one hundred fifty small holes indicated as 27 which extend for a distance of about two to four inches inwardly from tip 24.
  • the holes 27 should have diameters of 0.010 inch to 0.025 inch, and for best results are preferably between 0.015 inch and 0.020 inch. If the holes are smaller than 0.010 inch, they will be difiicult to make and they will limit the rate of fluid flow too much. If the holes are larger than 0.025 inch, portions of the omentum can pass through the holes into the bore 26. Swelling of the omentum can then plug the bore 26.
  • catheter 23 is provided with a smooth, cylindrical outer surface without projecting bosses or flanges which can irritate abdonimal tissues.
  • the catheter 23 is formed by cutting a section of extruded nylon tubing about eight to fourteen inches long, punching holes 27, forming the curved section 25, washing the tubing, and finally molding the tip 24.
  • the holes 27 are punched by pins 50 mounted in pin block 51.
  • the pin should be 0.013 inch to 0.028 inch in diameter and mounted so as to extend through the insulation 52 and the catheter holding jig 53 and to pierce the wall of the catheter tubing, without touching the opposite wall of the tubing.
  • a heating unit 54 is located between pin block 51 and press platen 55. Heating unit 54 preferably has a thermostatic control (not shown) by means of which the temperature of pins 50 may be adjusted.
  • Excellent results may be obtained in the hole-punching operation by using a one-half inch steel pin of the ordinary straight-pin or map-pin type.
  • a one-half inch steel pin of the ordinary straight-pin or map-pin type usually has a diameter of approximately 0.020 inch and, after some recovery of the plastic wall, forms a hole about 0.016 to 0.018 inch in diameter.
  • the temperature of the pins 50 is adjusted to a point where they soften, but do not melt, the wall of the thermoplastic tubing. In this way the plastic material displaced by the pin, is pushed inwardly, forming an indented outer surface 28 and an inner collar or flange 29. A silicone coating applied to to the pins as they are withdrawn.
  • the curved section 25 is then formed by placing a stiff,
  • the tubing and mandrel are then cooled to room temperature, the mandrel removed, and the tubing washed, rinsed and dried.
  • the rounded. tip 24 is then formed by heating and forming the end of the tubing.
  • a method of making a catheter for peritoneal dialysis comprising: cutting a length of extruded, thermoplastic tubing, said tubing having the desired physical properties and including a bore defined by a generally cylindrical, semirigid, self-supporting wall; coating a pointed pin with silicone; heating said pin to a temperature above the softening point but below the melting point of the tubing; pressing the point of the heated'pin against the outer sur-j face of the tubing wall near one end of the tubing to form a permanent indentation; further pressing the point of the pin against the side wall forcing the pin to pierce said wall and enter the bore of the tubing; stopping the movement of said pin while the point is in the tube bore and before the point contacts the opposite wall of the tubing; retracting the pin from the tubing wall, the siliconeserving to release the pin without causing projecting discontinuities on the outer surface of the tubing; forming a curved section along the perforated end portion of the tubing; and forming a smooth rounded tip on the end of said
  • Amethod of making very small holes in a semirigid, tubular, thermoplastic catheter comprising: heating a plurality of pointed, solid, metal pins to a temperature above the softening point, but below the melting point, of the catheter material; pressing the points of the heated pins against the outer surface of the unheated plastic catheter to form a permanent indentation. in said outer surface; further pressing the points of the heated pins to permanently displace a portion of the catheter wall into the catheter lumen and to form an opening'in said wall,
  • said opening being surrounded on the outer surfaceby an indentation, and on the inner surface by an inwardly projecting, deformed catheter wall portion; and withdrawing the pin from the catheter wall.

Description

Sept. 15, 1964 G. COANDA METHOD FOR MAKING A CATHETER FIG. Ii
56 L57 f| l- I 1 I 3/ 58 y 32 X j /5 I6 37 37 Original Filed June 4, 1959 FIG, 3 FIG. 4.
INVENTOR United States Patent This invention relates to a method for making an improved catheter for peritoneal dialysis.
This application is a division of the inventors copending application Serial No. 818,080, filed lune 4, 1959, now Patent No. 3,064,653.
Acute renal failure may be caused by infection, transfusion reactions, sulfonamide hypersensitivity, or poisoning. Excessive quantities of bromides, salicyclates, or barbiturates are among the common causes. Although the renal failure may be reversible, it is often diflicult to keep the patient alive until renal function can recover.
Peritoneal dialysis has been used in patients having acute renal failure to remove toxic materials from the blood. In this procedure, the peritoneal cavity is filled with a dialyzing solution and the peritoneum serves as a living, semi-permeable membrane. Peritoneal dialysis has not been widely used however, because of certain problems. For example, continuous peritoneal dialysis may cause pooling and channeling of fluid in the abdomen or excessive losses of blood proteins. It also uses relatively large volumes of dialysis fluid and requires a somewhat complicated apparatus. Intermittent peritoneal dialysis has not been widely used because of the difficulty in draining dialysis fluid from the abdominal cavity. Attempts to improve drainage of the fluid by providing the dialysis catheter with larger holes have merely aggravated the problem. Flutes, spiral grooves, and other external catheter shapes designed to shield the catheter holes, in crease irritation of the abdominal tissues and require use of a larger trocar than is desirable.
It is therefore an object of this invention to provide a method of making an improved catheter for intermittent peritoneal dialysis.
Another object of this invention is to provide a method of making a catheter which will facilitate withdrawal of the dialysis fluid.
A further object of the invention is to provide a method of making a peritoneal dialysis catheter having a small outside diameter and a smooth outer surface.
Other objects and advantages of my invention will be apparent from the following description of the preferred embodiment of the invention in which:
FIGURE 1 shows an administration set incorporating a catheter made by this invention;
FIGURE 2 is a plan'view of the catheter 23 partially cut away at the tip;
FIGURE 3 is a sectional view on the line 6-6 of FIG- URE 2;
FIGURE 4 is a partial enlargement of FIGURE 3; and
FIGURE 5 is a front elevation, partly in section, of a device for punching the holes in catheter 23.
As shown in the drawings, the administration set 10 has two stoppers 15, 16. An inlet tube 11 or 12 is attached to each stopper and is connected, by means of a Y-shaped connector 13, to the flexible administration tube 14. The tube 14 has a metal clamp 17 which, when bent, adjusts or shuts off flow by squeezing the tube 14. The distal end of tube 14 is attached by sleeve 18 to the connecting tube 19, the latter also having a metal clamp 20. A second sleeve 21 connects the distal end of the tube 19 to the proximal end 22 of catheter 23.
3,149,186 Patented Sept. 15, 1964 ICE- The catheter 23 is made of an inert, semi-rigid thermoplastic material which will not soften unduly at body temperature. For the purpose of this application, a semirigid tube is defined as a tube which cannot be collapsed by direct hand pressure, which is relatively rigid longitudinally for lengths of one half inch or so, but which is easily bent by hand in lengths of three inches or more. Catheters made from such tubes will not kink or collapse in normal use, out they will bend along their length when necessary so as to minimize trauma. For example, the catheter 23 can be made of nylon, high density polyethylene, Teflon, or Kel-F. Catheter 23 is usually eight to fourteen inches long, has an outside diameter of about 0.1 to 0.2 inch and has a sufiicient wall thickness to make it semi-rigid as defined above.
As a specific example, an excellent catheter has been made from a nylon tube having an outside diameter of 0.136 inch. A catheter of this size fits easily within the bore of a 17-French, Duke trocar so that only a small incision is necessary. A Wall thickness of approximately 0.015 inch makes the catheter semi-rigid, while at the same time providing a relatively large inner passage or bore. Such a catheter will bend when it meets an obstruction, but returns to its original shape.
The distal end of catheter 23 has a smooth rounded tip 24. A curved section 25, having a radius of about ten to fourteen inches, extends inwardly from tip 24 for a distance of about three to four inches. A passage or bore 26 passes axially through the catheter 23.
The distal portion of catheter 23 is provided with seventy to one hundred fifty small holes indicated as 27 which extend for a distance of about two to four inches inwardly from tip 24. The holes 27 should have diameters of 0.010 inch to 0.025 inch, and for best results are preferably between 0.015 inch and 0.020 inch. If the holes are smaller than 0.010 inch, they will be difiicult to make and they will limit the rate of fluid flow too much. If the holes are larger than 0.025 inch, portions of the omentum can pass through the holes into the bore 26. Swelling of the omentum can then plug the bore 26.
The outer edges of the holes 27 curve inwardly forming indented, rounded surfaces 28 and inwardly extending collars or flanges 29. In this manner, catheter 23 is provided with a smooth, cylindrical outer surface without projecting bosses or flanges which can irritate abdonimal tissues.
The catheter 23 is formed by cutting a section of extruded nylon tubing about eight to fourteen inches long, punching holes 27, forming the curved section 25, washing the tubing, and finally molding the tip 24.
As shown in FIGURE 5, the holes 27 are punched by pins 50 mounted in pin block 51. The pin should be 0.013 inch to 0.028 inch in diameter and mounted so as to extend through the insulation 52 and the catheter holding jig 53 and to pierce the wall of the catheter tubing, without touching the opposite wall of the tubing. A heating unit 54 is located between pin block 51 and press platen 55. Heating unit 54 preferably has a thermostatic control (not shown) by means of which the temperature of pins 50 may be adjusted.
Excellent results may be obtained in the hole-punching operation by using a one-half inch steel pin of the ordinary straight-pin or map-pin type. Such a pin usually has a diameter of approximately 0.020 inch and, after some recovery of the plastic wall, forms a hole about 0.016 to 0.018 inch in diameter.
In punching the holes 27, the temperature of the pins 50 is adjusted to a point where they soften, but do not melt, the wall of the thermoplastic tubing. In this way the plastic material displaced by the pin, is pushed inwardly, forming an indented outer surface 28 and an inner collar or flange 29. A silicone coating applied to to the pins as they are withdrawn.
The curved section 25 is then formed by placing a stiff,
curved, metal mandrel inside the tubing, and heating the tubing and mandrel in an oven for five minutes at about 275 F. The tubing and mandrel are then cooled to room temperature, the mandrel removed, and the tubing washed, rinsed and dried. The rounded. tip 24 is then formed by heating and forming the end of the tubing.
.1 claim:
1. A method of making a catheter for peritoneal dialysis comprising: cutting a length of extruded, thermoplastic tubing, said tubing having the desired physical properties and including a bore defined by a generally cylindrical, semirigid, self-supporting wall; coating a pointed pin with silicone; heating said pin to a temperature above the softening point but below the melting point of the tubing; pressing the point of the heated'pin against the outer sur-j face of the tubing wall near one end of the tubing to form a permanent indentation; further pressing the point of the pin against the side wall forcing the pin to pierce said wall and enter the bore of the tubing; stopping the movement of said pin while the point is in the tube bore and before the point contacts the opposite wall of the tubing; retracting the pin from the tubing wall, the siliconeserving to release the pin without causing projecting discontinuities on the outer surface of the tubing; forming a curved section along the perforated end portion of the tubing; and forming a smooth rounded tip on the end of said portion.
2. A method of making a catheter for peritoneal dialysis as set forth in claim 1 wherein the curved section of the tubing is formed by placing a stilt, curved wiremanraise further pressing the points of the heated pins against said catheter wall so as to permanently displace a portion of the wall into the catheter lumen; and withdrawing the pins frornthe catheter wall while retaining the indentations on the outer catheter surface.
4. Amethod of making very small holes in a semirigid, tubular, thermoplastic catheter comprising: heating a plurality of pointed, solid, metal pins to a temperature above the softening point, but below the melting point, of the catheter material; pressing the points of the heated pins against the outer surface of the unheated plastic catheter to form a permanent indentation. in said outer surface; further pressing the points of the heated pins to permanently displace a portion of the catheter wall into the catheter lumen and to form an opening'in said wall,
said opening being surrounded on the outer surfaceby an indentation, and on the inner surface by an inwardly projecting, deformed catheter wall portion; and withdrawing the pin from the catheter wall.
. References Cited in the filegof this patent UNITED STATES PATENTS 2,244,550 Chandler June 3, 1941 2,275,612 Chandler Man-10, 1942 2,802,530 Kaufman Aug. 13, 1957 2,876,496 Murphy Mar. 10,- 1959 2,964,796 Press Dec. 20,1960
' FOREIGN PATENTS 166,588 Australia Decy3, 1958

Claims (1)

1. A METHOD OF MAKING A CATHETER FOR PERITONEAL DIALYSIS COMPRISING: CUTTING A LENGTH OF EXTRUDED, THERMOPLASTIC TUBING, SAID TUBING HAVING THE DESIRED PHYSICAL PROPERTIES AND INCLUDING A BORE DEFINED BY A GENERALLY CYLINDRICAL, SEMIRIGID, SELF-SUPPORTING WALL; COATING A POINTED PIN WITH SILICONE; HEATING SAID PIN TO A TEMPERATURE ABOVE THE SOFTENING POINT BUT BELOW THE MELTING POINT OF THE TUBING; PRESSING THE POINT OF THE HEATED PIN AGAINST THE OUTER SURFACE OF THE TUBING WALL NEAR ONE END OF THE TUBING TO FORM A PERMANENT INDENTATION; FURTHER PRESSING THE POINT OF THE PIN AGAINST THE SIDE WALL FORCING THE PIN TO PIERCE SAID WALL AND ENTER THE BORE OF THE TUBING; STOPPING THE MOVEMENT OF SAID PIN WHILE THE POINT IS IN THE TUBE BORE AND BEFORE THE POINT CONTACTS THE OPPOSITE WALL OF THE TUBING; RETRACTING THE PIN FROM THE TUBING WALL, THE SILICONE SERVING TO RELEASE THE PIN WITHOUT CAUSING PROJECTING DISCONTINUTIES ON THE OUTER SURFACE OF THE TUBING; FORMING A CURVED SECTION ALONG THE PERFORATED END PORTION OF THE TUBING; AND FORMING A SMOOTH ROUNDED TIP ON THE END OF SAID PORTION.
US18368562 1959-06-04 1962-02-09 Method for making a catheter Expired - Lifetime US3149186A (en)

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US81808059 US3064653A (en) 1959-06-04 1959-06-04 Catheter for an administration set
US18368562 US3149186A (en) 1959-06-04 1962-02-09 Method for making a catheter

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Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292270A (en) * 1979-06-22 1981-09-29 Baxter Travenol Laboratories, Inc. Method and apparatus for making coude catheters
US5473843A (en) * 1993-01-29 1995-12-12 Fiat Products Ltd. Shower enclosure
US5510070A (en) * 1990-02-07 1996-04-23 Smith & Nephew Dyonics, Inc. Method of fabricating a surgical instrument
US20070093754A1 (en) * 2005-09-12 2007-04-26 Mogensen Lasse W Invisible needle
WO2008104603A1 (en) 2007-02-28 2008-09-04 Coloplast A/S Method for rounding edges of openings in a tubular body and a product thereof
US20100030155A1 (en) * 2006-08-02 2010-02-04 Steffen Gyrn Cannula and Delivery Device
US20100280498A1 (en) * 2007-06-20 2010-11-04 Jan Kent Olsen Catheter and a method and an apparatus for making such catheter
US20110040254A1 (en) * 2008-02-20 2011-02-17 Steffen Gyrn Insertion Device with Horizontally Moving Part
US20110098652A1 (en) * 2008-02-13 2011-04-28 Unomedical A/S Moulded Connection between Cannula and Delivery Part
US20110168294A1 (en) * 2008-05-30 2011-07-14 Claus Jakobsen Reservoir filling device
US8562567B2 (en) 2009-07-30 2013-10-22 Unomedical A/S Inserter device with horizontal moving part
US8790311B2 (en) 2006-06-09 2014-07-29 Unomedical A/S Mounting pad
US9211379B2 (en) 2006-02-28 2015-12-15 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
US9254373B2 (en) 2008-12-22 2016-02-09 Unomedical A/S Medical device comprising adhesive pad
US9278173B2 (en) 2005-12-23 2016-03-08 Unomedical A/S Device for administration
US9415159B2 (en) 2010-03-30 2016-08-16 Unomedical A/S Medical device
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
US9533092B2 (en) 2009-08-07 2017-01-03 Unomedical A/S Base part for a medication delivery device
US9724127B2 (en) 2010-09-27 2017-08-08 Unomedical A/S Insertion system and insertion kit
WO2020221664A1 (en) 2019-04-30 2020-11-05 Biotronik Ag Flexible elongated tube for a catheter system
US10898643B2 (en) 2008-02-13 2021-01-26 Unomedical A/S Sealing between a cannula part and a fluid path
US11020526B2 (en) 2010-10-04 2021-06-01 Unomedical A/S Sprinkler cannula
US11110261B2 (en) 2011-10-19 2021-09-07 Unomedical A/S Infusion tube system and method for manufacture
US11197689B2 (en) 2011-10-05 2021-12-14 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP4154934A1 (en) * 2021-09-22 2023-03-29 DePuy Synthes Products, Inc. An introducer sheath having an intentional friction zone to hold in position a delivery system suitable for implantable intravascular devices

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US2802530A (en) * 1952-10-23 1957-08-13 Amerace Corp Method of and apparatus for making a sprinkler hose
US2876496A (en) * 1955-12-16 1959-03-10 Dade Reagents Inc Process for making tubes
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US2275612A (en) * 1940-12-11 1942-03-10 Chandler Frank Jermain Perforating method and apparatus
US2802530A (en) * 1952-10-23 1957-08-13 Amerace Corp Method of and apparatus for making a sprinkler hose
US2964796A (en) * 1955-12-15 1960-12-20 Resistoflex Corp Preformed flexible hose and method of making it
US2876496A (en) * 1955-12-16 1959-03-10 Dade Reagents Inc Process for making tubes

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292270A (en) * 1979-06-22 1981-09-29 Baxter Travenol Laboratories, Inc. Method and apparatus for making coude catheters
US5510070A (en) * 1990-02-07 1996-04-23 Smith & Nephew Dyonics, Inc. Method of fabricating a surgical instrument
US5707350A (en) * 1990-02-07 1998-01-13 Smith & Nephew Endoscopy Inc. Surgical instrument
US5473843A (en) * 1993-01-29 1995-12-12 Fiat Products Ltd. Shower enclosure
US20070093754A1 (en) * 2005-09-12 2007-04-26 Mogensen Lasse W Invisible needle
US10369277B2 (en) 2005-09-12 2019-08-06 Unomedical A/S Invisible needle
US9278173B2 (en) 2005-12-23 2016-03-08 Unomedical A/S Device for administration
US9211379B2 (en) 2006-02-28 2015-12-15 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
US8790311B2 (en) 2006-06-09 2014-07-29 Unomedical A/S Mounting pad
US20100030155A1 (en) * 2006-08-02 2010-02-04 Steffen Gyrn Cannula and Delivery Device
US8945057B2 (en) 2006-08-02 2015-02-03 Unomedical A/S Cannula and delivery device
EP2944345A1 (en) 2007-02-28 2015-11-18 Coloplast A/S Method for rounding edges of openings in a tubular body
WO2008104603A1 (en) 2007-02-28 2008-09-04 Coloplast A/S Method for rounding edges of openings in a tubular body and a product thereof
US8475699B2 (en) * 2007-02-28 2013-07-02 Coloplast A/S Method for rounding edges of openings in a tubular body and a product thereof
EP3698839A1 (en) 2007-02-28 2020-08-26 Coloplast A/S Intermittent catheter
JP2010519945A (en) * 2007-02-28 2010-06-10 コロプラスト アクティーゼルスカブ Method for rounding edges of openings in tubular bodies and products thereof
CN101626798B (en) * 2007-02-28 2014-08-06 科洛普拉斯特公司 Method for rounding edges of openings in a tubular body and a product thereof
US20100324535A1 (en) * 2007-02-28 2010-12-23 Coloplast A/S Method for rounding edges of openings in a tubular body and a product thereof.
EP2129424B1 (en) 2007-02-28 2015-05-27 Coloplast A/S Catheter with openings in a tubular body having rounded edges
US9320869B2 (en) 2007-06-20 2016-04-26 Unomedical A/S Apparatus for making a catheter
US20100280498A1 (en) * 2007-06-20 2010-11-04 Jan Kent Olsen Catheter and a method and an apparatus for making such catheter
US9186480B2 (en) * 2007-06-20 2015-11-17 Unomedical A/S Apparatus for making a catheter
US10898643B2 (en) 2008-02-13 2021-01-26 Unomedical A/S Sealing between a cannula part and a fluid path
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