US3293133A - Method of imparting color to pharmaceutical solutions - Google Patents
Method of imparting color to pharmaceutical solutions Download PDFInfo
- Publication number
- US3293133A US3293133A US275230A US27523063A US3293133A US 3293133 A US3293133 A US 3293133A US 275230 A US275230 A US 275230A US 27523063 A US27523063 A US 27523063A US 3293133 A US3293133 A US 3293133A
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- United States
- Prior art keywords
- aqueous pharmaceutical
- coloring
- solution
- coloring material
- color
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Definitions
- This invention has as one of its objects the preparation of aqueous pharmaceutical solutions possessing uniform color characteristics, which color characteristics are not lost after storage for extended periods of time.
- Another object of this invention is the application of a water insoluble coloring material to an aqueous pharmaceutical solution.
- Still another object of this invention is the imparting of a color to a pharmaceutical solution by the employment of Food and Drug Administration approved coloring materials.
- Yet another object of this invention is the imparting of a color to a pharmaceutical solution by the employment of an economical and efiicient method not heretofore known.
- the coloring materials which may be employed in the practice of this invention are those which are substantially water insoluble and are certified for use in pharmaceutical compositions. More specifically, they include such dyes designated by their Food and Drug Administration designations as D & C Blue No. 6, D & C Blue No. 9, D & C Green No. 6, D & C Violet No. 2, D & C Red No. 17, D & C Red No. 19, D & C Red No.21, D & C Orange No. 5, D & C Yellow No. 7, D '& C Yellow No. 11, D & C RedNo. 6,D&CRedNo. 7, D&CRedNo. 35,D&C Orange No. 15, D & C Yellow No. 6, D & C Green No. 1, D & C Blue No. 1, D & C Violet No. 7, and other like coloring materials. Further exemplary are the substantially Water insoluble FD & C and D & C colors listed in the Merck Index, Sixth Edition.
- the coloring material is first dissolved in an organic solvent and the resulting solution is deposited on the surface of a free-flowing particulate, water soluble material.
- organic solvents which may be employed in the practice of this invention are those volatile solvents in Which the respective coloring material may be completely dissolved. They include such organic solvents as acetone, methanol, benzene, ethanol and other like volatile solvents. In the most preferable embodiment of this invention, acetone is employed, although the other solvents yield the same results.
- the particulate water soluble material which may be employed in the practice of this invention, is one which is non-toxic, pharrnaceutically acceptable and is free-flowing and will absorb the water insoluble coloring material on the surface thereof and includes such materials as sugars, such as lactose, sucrose or dextrose; salts, such as sodium chloride, or potassium chloride; and hydrocolloids, such as acacia, guar gum, tragacanth, sodium carboxy methyl cellulose, gelatin and mannitol.
- sugars such as lactose, sucrose or dextrose
- salts such as sodium chloride, or potassium chloride
- hydrocolloids such as acacia, guar gum, tragacanth, sodium carboxy methyl cellulose, gelatin and mannitol.
- crystalline sucrose is employed.
- the coloring material in the solution is deposited on the surface of the water soluble particulate material, the solvent is driven off yielding a substantially dry, coloring composition comprising a freely dispersible particulate water soluble material, having the substantially water insoluble coloring material intimately and uniformly adherent to the surfaces thereof.
- This coloring composition may be employed directly and immediately in imparting a color to a pharmaceutical solution or it may be held in its substantially dry state for future use in the furtherance of the principles of this invention.
- the coloring composition is employed to impart color to any aqueous pharmaceutical solution by its intimate dispersion into the pharmaceutical solution to be treated.
- This intimate dispersion may be accomplished in any manner known to the art to accomplish such an objective, for example, by introducing the desired amount of substantially dry coloring composition into the aqueous pharmaceutical solution by vigorous mixing, as by treatment on a rotary shaker until a substantially uniform coloris obtained.
- the amounts of the respective ingredients which may be employed in the practice of this invention are those which will impart a uniform color to an aqueous pharmaceutical solution. It has been found that the respective amount of the ingredients which may be used to produce the final products of this invention are from about 0.001% to about 1.0% by weight of the insoluble coloring material about 0.1% to about 20.0% of the water soluble particulate material and about 75.0% to about 99.9% of the aqueous pharmaceutical solution.
- aqueous pharmaceutical solutions which may be employed in the practice of this invention include those solutions which possess antibiotic, steroidal and diuretic activity. Included in such aqueous pharmaceutical solutions are tetracycline compositions, amphotericin compositions, progestogen compositions, benzothiadiazine compositions and other like pharmaceutical preparations. In the most preferable embodiment of this invention the aqueous pharmaceutical product is one of antibiotic activity, such as tetracycline, although others may be employed with like results.
- Example 1 Into 6.0 cc. of ace-tone there is dissolved 0.12 g. of D & C dye Red No. 21 with stirring. The resultant solution is then sprayed evenly over the surface of 25 g. of crystalline sucrose in a revolving pan until the entire surface of the sucrose has been colored by the solution. The acetone solvent is then driven off and the resultant dried colored sucrose is then dissolved in 1000 mi. of a 31% aque-.
- a process for imparting a uniform color to an aqueous pharmaceutical solution which comprises (a) dissolving a water insoluble pharmaceutically acceptable non-toxic coloring material in an organic solvent;
- a coloring composition for imparting a water insoluble color to an aqueous pharmaceutical solution which comprises a substantially free-flowing, non-toxic, pharmaceutically acceptable water somluble particulate material selected from the group consisting of sugars, salts and hydrocolloids having a water insoluble coloring material adherent to the surfaces thereof.
- a process for imparting a uniform color to an aqueous pharmaceutical solution which comprises:
- organic solvent is selected from the group consisting of acetone, methanol, ethanol, and benzene.
- particulate material is selected from the group consisting of lactose, sucrose, dextrose, sodium chloride, potassium chloride, acacia, guar gum, tragacanth, sodium carboxyrnethylcellulose, gelatin and mannitol.
- composition in accordance with claim 2 wherein the particulate material is sucrose.
- composition in accordance with claim 6 wherein the water-insoluble coloring material is D & C No. 21.
Description
United States Patent 3,293,133 METHOD OF IMPARTING COLOR TO PHARMA- CEUTICAL SOLUTIONS John A. Hill, New Brunswick, N.J., assignor to E. R. Squibb & Sons Inc., New York, N.Y., a corporation of Delaware N0 Drawing. Filed Apr. 24, 1963, Ser. No. 275,230 7 Claims. (Cl. 16782) This invention relates to new coloring compositions and to novel processes for imparting a color to a pharmaceutical solution. More particularly, this invention relates to methods for applying water insoluble colors to aqueous pharmaceutical preparations and the new coloring compositions employed therefor.
Heretofore, it has been possible to color an aqueous pharmaceutical solution only by employing exceedingly large quantities of the water insoluble coloring material and the results obtained have not been uniformly satisfactory. It was found that a water insoluble coloring material, when applied to an aqueous pharmaceutical solution, behaves like a pigment, and exceedinly large quantities must be used to impart a color thereto. After these large quantities of coloring material are employed, the color of the resultant pharmaceutical composition was unsatisfactory, as the insoluble coloring material settled out in substantial amounts, even after only short periods of storage.
A great number of coloring materials which may otherwise be satisfactorily employed for the purposes here desired may not be used in pharmaceutical compositions as their use is forbidden or limited by the Food and Drug Administration.
This invention has as one of its objects the preparation of aqueous pharmaceutical solutions possessing uniform color characteristics, which color characteristics are not lost after storage for extended periods of time.
Another object of this invention is the application of a water insoluble coloring material to an aqueous pharmaceutical solution.
Still another object of this invention is the imparting of a color to a pharmaceutical solution by the employment of Food and Drug Administration approved coloring materials.
Yet another object of this invention is the imparting of a color to a pharmaceutical solution by the employment of an economical and efiicient method not heretofore known.
Still other objects of this invention will become apparent from a further reading of this specification.
The coloring materials, which may be employed in the practice of this invention are those which are substantially water insoluble and are certified for use in pharmaceutical compositions. More specifically, they include such dyes designated by their Food and Drug Administration designations as D & C Blue No. 6, D & C Blue No. 9, D & C Green No. 6, D & C Violet No. 2, D & C Red No. 17, D & C Red No. 19, D & C Red No.21, D & C Orange No. 5, D & C Yellow No. 7, D '& C Yellow No. 11, D & C RedNo. 6,D&CRedNo. 7, D&CRedNo. 35,D&C Orange No. 15, D & C Yellow No. 6, D & C Green No. 1, D & C Blue No. 1, D & C Violet No. 7, and other like coloring materials. Further exemplary are the substantially Water insoluble FD & C and D & C colors listed in the Merck Index, Sixth Edition.
It has now been found that a uniform color, which is retained by the aqueous pharmaceutical solution, even after extended periods, may be produced by the employment of 'a water insoluble coloring material. According to the novel process of this invention, the coloring material is first dissolved in an organic solvent and the resulting solution is deposited on the surface of a free-flowing particulate, water soluble material.
The organic solvents which may be employed in the practice of this invention are those volatile solvents in Which the respective coloring material may be completely dissolved. They include such organic solvents as acetone, methanol, benzene, ethanol and other like volatile solvents. In the most preferable embodiment of this invention, acetone is employed, although the other solvents yield the same results. The particulate water soluble material which may be employed in the practice of this invention, is one which is non-toxic, pharrnaceutically acceptable and is free-flowing and will absorb the water insoluble coloring material on the surface thereof and includes such materials as sugars, such as lactose, sucrose or dextrose; salts, such as sodium chloride, or potassium chloride; and hydrocolloids, such as acacia, guar gum, tragacanth, sodium carboxy methyl cellulose, gelatin and mannitol.
In the most preferable embodiment of the invention, crystalline sucrose is employed. The coloring material in the solution is deposited on the surface of the water soluble particulate material, the solvent is driven off yielding a substantially dry, coloring composition comprising a freely dispersible particulate water soluble material, having the substantially water insoluble coloring material intimately and uniformly adherent to the surfaces thereof. This coloring composition may be employed directly and immediately in imparting a color to a pharmaceutical solution or it may be held in its substantially dry state for future use in the furtherance of the principles of this invention.
The coloring composition is employed to impart color to any aqueous pharmaceutical solution by its intimate dispersion into the pharmaceutical solution to be treated. This intimate dispersion may be accomplished in any manner known to the art to accomplish such an objective, for example, by introducing the desired amount of substantially dry coloring composition into the aqueous pharmaceutical solution by vigorous mixing, as by treatment on a rotary shaker until a substantially uniform coloris obtained.
The amounts of the respective ingredients which may be employed in the practice of this invention are those which will impart a uniform color to an aqueous pharmaceutical solution. It has been found that the respective amount of the ingredients which may be used to produce the final products of this invention are from about 0.001% to about 1.0% by weight of the insoluble coloring material about 0.1% to about 20.0% of the water soluble particulate material and about 75.0% to about 99.9% of the aqueous pharmaceutical solution.
The aqueous pharmaceutical solutions which may be employed in the practice of this invention include those solutions which possess antibiotic, steroidal and diuretic activity. Included in such aqueous pharmaceutical solutions are tetracycline compositions, amphotericin compositions, progestogen compositions, benzothiadiazine compositions and other like pharmaceutical preparations. In the most preferable embodiment of this invention the aqueous pharmaceutical product is one of antibiotic activity, such as tetracycline, although others may be employed with like results.
The following example is illustrative of the invention:
Example 1 Into 6.0 cc. of ace-tone there is dissolved 0.12 g. of D & C dye Red No. 21 with stirring. The resultant solution is then sprayed evenly over the surface of 25 g. of crystalline sucrose in a revolving pan until the entire surface of the sucrose has been colored by the solution. The acetone solvent is then driven off and the resultant dried colored sucrose is then dissolved in 1000 mi. of a 31% aque-.
ous suspension of tetracycline with vigorous mixing to yield a substantially evenly colored aqueous suspension of tetracycline.
Similarly, if equivalent amounts of aqueous pharmaceutical solutions of such pharmaceuticals as tetracycline, dimethyltetracycline, amphotericin etc. are substituted for tetracycline, like results are obtained.
, The invention may be variously otherwise embodied within the scope of the appended claims. What is claimed is:
1. A process for imparting a uniform color to an aqueous pharmaceutical solution which comprises (a) dissolving a water insoluble pharmaceutically acceptable non-toxic coloring material in an organic solvent;
(b) dispersing the said coloring material over the surface of a Water soluble pharmaceutically acceptable free-flowing particulate material selected from the group consisting of sugars, salts and hydrocolloids by contacting said particulate material with the said colored organic solution;
(c) removing the said organic solvent to obtain a substantially dry coloring composition comprising particulate material having adherent to the surfaces thereof the said insoluble coloring material; and
(d) intimately introducing into an aqueous pharmaceutical product the said coloring composition to obtain a uniformly colored aqueous pharmaceutical solution.
2. A coloring composition for imparting a water insoluble color to an aqueous pharmaceutical solution which comprises a substantially free-flowing, non-toxic, pharmaceutically acceptable water somluble particulate material selected from the group consisting of sugars, salts and hydrocolloids having a water insoluble coloring material adherent to the surfaces thereof.
3. A process for imparting a uniform color to an aqueous pharmaceutical solution which comprises:
(a) dissolving a water-insoluble pharmaceutically acceptable non-toxic coloring material in an organic solvent;
(b) dispersing the coloring material over the surface of a water-soluble pharmaceutically acceptable freeflowing crystalline sucrose material by contacting said material with the colored organic solution;
(0) removing the said organic solvent to obtain a substantially dried coloring composition comprising particulate sucrose having adherent to the surfaces thereof the said insoluble material;
(d) intermittently introducing into an aqueous pharmaceutical product the said coloring composition to obtain a uniformly colored aqueous pharmaceutical solution.
4. A process in accordance with the process of claim 1 wherein the organic solvent is selected from the group consisting of acetone, methanol, ethanol, and benzene.
5. A process in accordance with the process of claim 1 wherein the particulate material is selected from the group consisting of lactose, sucrose, dextrose, sodium chloride, potassium chloride, acacia, guar gum, tragacanth, sodium carboxyrnethylcellulose, gelatin and mannitol.
6. A composition in accordance with claim 2 wherein the particulate material is sucrose.
7. A composition in accordance with claim 6 wherein the water-insoluble coloring material is D & C No. 21.
References Cited by the Examiner UNITED STATES PATENTS 2,553,617 5/1951 Wendt 99-148 2,610,917 9/1952 Hensgen 99l48 2,693,436 11/ 1954 Spradling l6782 2,841,499 7/ 1958 Grossi 99148 2,925,365 2/ 1960 Nicholson et a1. 16-782 3,028,307 4/1962 Ninger 16782 3,054,724 9/1962 Raff 16782 3,079,303 2/1963 Raff et a1. 16782 3,105,008 9/ 1963 Kaplan et al 16782 3,200,039 8/1965 Thompson 16'782 FOREIGN PATENTS 269,796 4/ 1927 Great Britain.
JULIAN S. LEVITI, Primary Examiner.
FRANK CACC-IAPAGLIA, 1a., Examiner.
GEORGE A. MENTIS, Assistant Examiner.
Claims (1)
1. A PROCESS FOR IMPARTING A UNIFORM COLOR TO AN AQUEOUS PHARMACEUTICAL SOLUTION WHICH COMPRISES (A) DISSOLVING A WATER INSOLUBLE PHARMACEUTICALLY ACCEPTABLE NON-TOXIC COLORING MATERIAL IN AN ORGANIC SOLVENT; (B) DISPERSING THE SAID COLORING MATERIAL OVER THE SURFACE OF A WATER SOLUBLE PHARMACEUTICALLY ACCEPTABLE FREE-FLOWING PARTICULATE MATERIAL SELECTED FROM THE GROUP CONSISTING OF SUGARS, SALTS AND HYDROCOLLOIDS BY CONTACTING SAID PARTICULATE MATERIAL WITH THE SAID COLORED ORGANIC SOLUTION; (C) REMOVING THE SAID ORGANIC SOLVENT TO OBTAIN A SUBSTANTIALLY DRY COLORING COMPOSITION COMPRISING PARTICULATE MATERIAL HAVING ADHERENT TO THE SURFACES THEREOF THE SAID INSOLUBLE COLORING MATERIAL; AND (D) INTIMATELY INTRODUCING INTO AN AQUEOUS PHARMACEUTICAL PRODUCT THE SAID COLORING COMPOSITION TO OBTAIN A UNIFORMLY COLORED AQUEOUS PHARMACEUTICAL SOLUTION.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US275230A US3293133A (en) | 1963-04-24 | 1963-04-24 | Method of imparting color to pharmaceutical solutions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US275230A US3293133A (en) | 1963-04-24 | 1963-04-24 | Method of imparting color to pharmaceutical solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3293133A true US3293133A (en) | 1966-12-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US275230A Expired - Lifetime US3293133A (en) | 1963-04-24 | 1963-04-24 | Method of imparting color to pharmaceutical solutions |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US3293133A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3619294A (en) * | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Method of combining crystalline sugar with impregnating agents and products produced thereby |
| JPS5029733A (en) * | 1973-07-18 | 1975-03-25 | ||
| JPS50101517A (en) * | 1974-01-22 | 1975-08-12 | ||
| US4029782A (en) * | 1975-04-28 | 1977-06-14 | Eli Lilly And Company | Cefazolin suspension for parenteral administration |
| US4537637A (en) * | 1980-08-19 | 1985-08-27 | The Coca-Cola Company | Hydration drying process |
| US8357417B2 (en) | 2010-03-31 | 2013-01-22 | Purecircle Sdn Bhd | Low calorie composite sweetener as sugar alternative and methods for producing the same |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB269796A (en) * | 1926-10-12 | 1927-04-28 | Alfred Owen Morris | Improvements in or connected with the manufacture of tinted or coloured pulverulent substances |
| US2553617A (en) * | 1946-03-07 | 1951-05-22 | Fred Fear & Company | Coloring composition capable of forming a film on water |
| US2610917A (en) * | 1949-05-21 | 1952-09-16 | Swift & Co | Coloring agent for plastic materials |
| US2693436A (en) * | 1951-02-27 | 1954-11-02 | Upjohn Co | Coating material for tablets and coated tablets |
| US2841499A (en) * | 1955-03-03 | 1958-07-01 | Union Starch & Refining Compan | Colored food product and method of making the same |
| US2925365A (en) * | 1957-11-27 | 1960-02-16 | Smith Kline French Lab | Coloring solid pharmaceutical forms and compositions therefor |
| US3028307A (en) * | 1959-05-27 | 1962-04-03 | Warner Lambert Pharmaceutical | Pre-dried granulation and production of sublingual compressed organic nitrate tablets with selected solubilizing agents |
| US3054724A (en) * | 1960-05-12 | 1962-09-18 | Smith Kline French Lab | Coloring discrete solids and compositions therefor |
| US3079303A (en) * | 1958-12-11 | 1963-02-26 | Smith Kline French Lab | Basic tablet granulation and process of using same |
| US3105008A (en) * | 1958-03-20 | 1963-09-24 | Bristol Myers Co | Tetracycline formulations |
| US3200039A (en) * | 1962-05-28 | 1965-08-10 | Pfizer & Co C | Non-granulated tablets with 20% sorbitol in a particle size of from about 100mu to about 2000mu |
-
1963
- 1963-04-24 US US275230A patent/US3293133A/en not_active Expired - Lifetime
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB269796A (en) * | 1926-10-12 | 1927-04-28 | Alfred Owen Morris | Improvements in or connected with the manufacture of tinted or coloured pulverulent substances |
| US2553617A (en) * | 1946-03-07 | 1951-05-22 | Fred Fear & Company | Coloring composition capable of forming a film on water |
| US2610917A (en) * | 1949-05-21 | 1952-09-16 | Swift & Co | Coloring agent for plastic materials |
| US2693436A (en) * | 1951-02-27 | 1954-11-02 | Upjohn Co | Coating material for tablets and coated tablets |
| US2841499A (en) * | 1955-03-03 | 1958-07-01 | Union Starch & Refining Compan | Colored food product and method of making the same |
| US2925365A (en) * | 1957-11-27 | 1960-02-16 | Smith Kline French Lab | Coloring solid pharmaceutical forms and compositions therefor |
| US3105008A (en) * | 1958-03-20 | 1963-09-24 | Bristol Myers Co | Tetracycline formulations |
| US3079303A (en) * | 1958-12-11 | 1963-02-26 | Smith Kline French Lab | Basic tablet granulation and process of using same |
| US3028307A (en) * | 1959-05-27 | 1962-04-03 | Warner Lambert Pharmaceutical | Pre-dried granulation and production of sublingual compressed organic nitrate tablets with selected solubilizing agents |
| US3054724A (en) * | 1960-05-12 | 1962-09-18 | Smith Kline French Lab | Coloring discrete solids and compositions therefor |
| US3200039A (en) * | 1962-05-28 | 1965-08-10 | Pfizer & Co C | Non-granulated tablets with 20% sorbitol in a particle size of from about 100mu to about 2000mu |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3619294A (en) * | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Method of combining crystalline sugar with impregnating agents and products produced thereby |
| JPS5029733A (en) * | 1973-07-18 | 1975-03-25 | ||
| JPS5812259B2 (en) * | 1973-07-18 | 1983-03-07 | ワコウジユンヤクコウギヨウ カブシキガイシヤ | Chiyakushiyokusareta Himakkei Seiyousoseibutsu |
| JPS50101517A (en) * | 1974-01-22 | 1975-08-12 | ||
| US4029782A (en) * | 1975-04-28 | 1977-06-14 | Eli Lilly And Company | Cefazolin suspension for parenteral administration |
| US4537637A (en) * | 1980-08-19 | 1985-08-27 | The Coca-Cola Company | Hydration drying process |
| US8357417B2 (en) | 2010-03-31 | 2013-01-22 | Purecircle Sdn Bhd | Low calorie composite sweetener as sugar alternative and methods for producing the same |
| US8591980B2 (en) | 2010-03-31 | 2013-11-26 | Purecircle Sdn Bhd | Low calorie composite sweetener as sugar alternative and methods for producing the same |
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