US3348542A - Anesthetic articles - Google Patents
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- US3348542A US3348542A US415326A US41532664A US3348542A US 3348542 A US3348542 A US 3348542A US 415326 A US415326 A US 415326A US 41532664 A US41532664 A US 41532664A US 3348542 A US3348542 A US 3348542A
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- 230000003444 anaesthetic effect Effects 0.000 title claims description 51
- 239000012528 membrane Substances 0.000 claims description 39
- 238000009792 diffusion process Methods 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 13
- 230000009975 flexible effect Effects 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 description 20
- 229920000298 Cellophane Polymers 0.000 description 10
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- 239000003193 general anesthetic agent Substances 0.000 description 8
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- 210000004072 lung Anatomy 0.000 description 5
- 230000002035 prolonged effect Effects 0.000 description 5
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- 229960004393 lidocaine hydrochloride Drugs 0.000 description 4
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
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- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
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- 230000036407 pain Effects 0.000 description 3
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- 235000017276 Salvia Nutrition 0.000 description 1
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- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- BZEWSEKUUPWQDQ-UHFFFAOYSA-N dyclonine Chemical compound C1=CC(OCCCC)=CC=C1C(=O)CCN1CCCCC1 BZEWSEKUUPWQDQ-UHFFFAOYSA-N 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 238000010879 hemorrhoidectomy Methods 0.000 description 1
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- 229960005388 hexylcaine Drugs 0.000 description 1
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- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- 229940072358 xylocaine Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/08—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of suppositories or sticks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0434—Cuffs
- A61M16/0436—Special fillings therefor
- A61M16/0438—Liquid-filled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0475—Tracheal tubes having openings in the tube
- A61M16/0477—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids
- A61M16/0481—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids through the cuff wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M19/00—Local anaesthesia; Hypothermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Definitions
- ABSTRACT OF THE DISCLOSURE A surfaceetfective anesthetic applicator for body pas sages. It includes a flexible, fluid-tight membrane that has a diffusion characteristic for the anesthetic. The membrane forms part of an inflatable container and the fluid anesthetic can both distend the wall into tissue contact and apply anesthetic to that tissue by diffusion.
- this applicator combined with a tube to transmit another fluid through the passage while the passage wall receives anesthetic.
- the tube ventilates the lungs, and the membrane forms a seal between the tube and the wall of the passage, to prevent escape of air.
- this applicator formed as a suppository.
- This invention relates to the administration of anesthetics.
- One object of the invention is to provide an improved means for administering surface effective anesthetics to body tissue.
- a more particular object is to provide a means for making a patient more comfortable during the treatment of body cavities and passages, and especially while mechanical devices such as tubes are inserted.
- Another object of the invention is to provide improved mechanical devices for insertion into body passages and cavities.
- Another object of the invention is to provide means for better controlling the administration of surface effective anesthetics.
- a more particular object is to enable administration over a controllable prolonged period, for instance a number of hours, or even a half day or longer.
- Another object is to enable administration at controllable dosage rates and total dosages.
- Still another object is to provide means which permits a better correlation between dosage rate of surface effective anesthetics and the observable effects of prior dosage.
- a still further object of the invention is to provide, in combination with mechanical devices, means to administer surface effective anesthetics over a prolonged period in a manner that does not harm body tissue and improves the use of the mechanical devices.
- Specific objects of the invention are to provide improved tracheal tube devices and improved suppositories.
- a membrane member can be used to contain a fluid surfaceeifective anesthetic, and can produce a progressive release at proper rate to tissues of the body in contact with the membrane. By this means extremely prolonged surface anesthesia of tissue can be achieved.
- a membrane device combined with a mechanical device enables use of the latter over a prolonged period without pain.
- the invention takes advantage of the impeded diffusion characteristic of membrane material, with the rate of release controlled by the selection of the membrane as well as by the conditions of the fluid itself.
- cellophane which incidentally is quite durable and is presently preferred, colloidon, silicone rubber, latex and animal membranes such as intestine walls. Selection of the membrane depends upon the char acteristics of the particular anesthetic fluid. Thus with a water solution anesthetic, which is preferred, cellophane is a very good membrane, and the dosage rate can be 3,348,542 Patented Oct. 24, 1967 controlled by thickness. Colloidon and animal membranes can also be use-d. For certain anesthetics, e.g. containing alcohol, more impedance may be acceptable, making rubberous materials useful; Alternatively, membrane materials may be specially treated, e.g.
- One treatment is to stretch a rubberous sheet and puncture it with needles which may be heated or shaped to remove rubber from the hole.
- Another treatment is to subject a rubberous sheet to electrical particles such as high energy electrons, or to an excessive electric field which can produce small holes in the sheet.
- FIG. 1 is a side view of one preferred embodiment of the device of the invention
- FIG. 2 is a median section view of a human being illustrating the use of the device of FIG. 1;
- FIG. 3 is a view similar to FIG. 2 of another preferred embodiment of the invention.
- FIG. 4 is a side view, partially in cross-section, of another preferred embodiment of the invention.
- FIG. 5 is a view showing the endotracheal tube of FIG 4 inserted in the trachea of a patient.
- a resilient tube 16, of smaller diameter D and of greater stiffness than the walls of tube 10 is disposed within the bag, at one end 14.
- ties 18 and 20 the bag is drawn against the tube 16, forming pleats in the bag.
- Holes 22 and 24 are provided in the tube on either side of the tie 18, enabling the part of the bag hugging the tube to receive liquid from the large end of the bag.
- the bag is filled with liquid surface-effective anesthetic 26, the membrane and anesthetic properties cooperatively related to enable anesthetic to be released through the membrane at an effective dosage rate.
- a bag 28 for instance in the form of a rubber prophylactic article, surrounds this entire assembly, and is tied off, at 30.
- the large end of the tube 10 serves as a stop. preventing further inward movement of the device.
- This end also serves as a supply.
- the resilient bag 28, in the stretched position shown in FIG. 2, serves to maintain pressure upon the bag to assist movement of the anesthetic. It also serves to cover the large end of the membrane bag, preventing loss of anesthetic from that region.
- the anesthetic need neither be discharged in a short time nor contained completely. Rather, by virtue ofv the impeded diffusion characteristic of the membrane relative to the anesthetic, a dosage rate can be maintained at a substantially effective level and body tissue in contact with the membrane can be thereby continually anesthetized.
- EXAMPLE 1 A rectal suppository such as shown in FIG. 1 was made and filled with surface-effective anesthetic.
- the tube 16 was used for filling, in this instance comprising arubber tube of OD. and wall thickness. It was inserted in the open end of the cellophane tube and this open end was tied securely about the rubber tube at 18 and 20.
- the cellophane tube employed was conventional Weck Sterilizing tubing furnished to hospitals by the Edward Weck & Co., division of Sterling Precision Corp. 4933 is regenerated cellulose plasticized with glycerol, and lubricated with neutral white oil.
- the cellophane tube 10 was tied off at 14, fully enclosing the rubber tube.
- the suppository was inserted into the patient following hemorrhoid surgery, in the position shown in FIG. 2. Insertion was facilitated by the relative stiffness of the rubber tube 16.
- the suppository caused no injury to the tissue.
- the effectiveness of the suppository can be prolonged by limiting the membrane area to that contacting the surgical area tissue. This can be accomplished by entirely or partially occluding the remainder of the walls, for instance by making those walls thicker or applying a coating such as rubber, or by means of the bag 28 as shown in FIG. 2.
- Various controls for the dosage rate of anesthetic are made possible by the device. At first there is the possibility of selection of the kind and concentration of the anesthetic and the membrane material. After a membrane material is selected, e.g. cellophane, then its thickness can be selected. For instance a .004" wall thickness can transmit a lighter, though effective, dose than a wall of .002. Then, during use, the amount of pressure upon the anesthetic can be adjusted, depending upon observation of the patient, and as well, the temperature of the anesthetic can be adjusted, increase in either increasing the dosage rate.
- other rectal drugs may be administrated through the membrane.
- a concentration of 1 to 100,000 epinephrine can be added. This will promote hemostasis (stop bleeding) and will conserve the anesthetic due to its effect of constricting the blood vessels and thus limiting the rate at which blood carries away the anesthetic.
- each end of the dumbbell is formed of membrane material, filled with surface-effective anesthetic and adapted to administer the anesthetic according to the invention.
- the large size of the ends 32 and 34 of the dumbbell serve as stops, preventing inward or outward movement.
- At least the inner end 34 is formed by a plurality of concentric membrane bags 35, 36, 37, 38.
- a fraction of the total charge of surface effective anesthetic In each space defined between a pair of these bags is held a fraction of the total charge of surface effective anesthetic.
- This fraction can be sized so that, in the event of accidental rupture of the outer wall 35, for instance, the sudden release of the amount of surface effective anesthe-tic to the body is limited to what the body can easily tolerate.
- each of the spaces can be filled with 6 cc. of 4% liodocaine hydrochloride.
- the plurality of bag walls increase the impedance to travel of anesthetic from the center of the bag, and thus serve to prolong the anesthetic effect of the device and control the dosage rate.
- the device is easily formed from a single tube by knotting, filling, knotting the open end, passing the tube over the filled portion, filling the space in between from the other end, knotting at the other end, and so on.
- an endotracheal tube 42 is provided having a cuff 40.
- the tube 42 can be of conventional design, defining an air passage that extends from the fitting 44 at the exterior end to the interior end.
- This tube is adapted to be connected to a ventilator to supply air to the lungs of a patient and to exhaust air from the lungs.
- the tube is formed of resilient material such as heavy rubber.
- the cuff 40 is located close to the interior end in the conventional manner. It surrounds the tube 42, defining an annular container, i.e., a short length sheath. It is more flexible than the tube 42.
- a relatively small supply tube 46 extends from the cuff for inflation purposes.
- the tissue contacting wall 48 of the cuff 40 is constructed and arranged as a membrane having a diffusion characteristic enabling an effective dosage rate of surface-effective liquid anesthetic 49 to pass through the wall to the tissue of the trachea.
- EXAMPLE 2 A conventional endotracheal tube was modified by removing the conventional relatively thick walled rubber cuff and aflixing a cuff formed of membrane material. In this instance the cuff was formed of the cellophane described in Example 1, tied at 41 and 43 to the tube 42.
- the cellophane was folded to hug tightly the outer surface of the endotracheal tube 42, and the tube was inserted through the mouth of the patient. Once in place liquid anesthetic (2% lidocaine hydrochloride) was introduced through supply tube 46 to the cuff 40 causing the cuff to inflate and engage a ring of tracheal tissue 47, thus creating a seal.
- anesthetic 2% lidocaine hydrochloride
- the anesthetic was progressively applied to the contacting tracheal tissue at an effective dosage due to the impeding diffusion characteristic of the membrane.
- Lidocaine 14% a surface effective anesthetic drug that are suitable for use are the following: Lidocaine 14%, Tetracaine 02-05%, Dyclonine 0.51%, Diothane 1%, Hexylcaine 5%, Cocaine 35% solution.
- Lidocaine 2% in volumes of 10-20 cc. is presently the preferred agent.
- Containers formed with walls of diffusion impeding membranes, filled with any of these surface effective anesthetic agents, may be inserted in body openings or surgical incisions and will provide effective surface anesthesia for 8-12 hours.
- An applicator device sized and shaped to removably enter a body opening and lie in a body passage, said device including a highly flexible, distensible, thin wall exposed to contact surface tissue that defines the body passage, the wall comprising a generally fluid-tight membrane having a diffusion characteristic for diffusion of surface-effective fluid anesthetic through its thickness, said wall being sealed to form at least a part of an inflatable container adapted to receive surface-effective fluid anesthetic, whereby the yieldable pressure of the fluid anesthetic introduced to said container itself can distend the wall into an intimately conforming tissue-contacting relationship to apply anesthetic to that tissue by diffusion.
- said membrane is selected from the group consisting of cellophane, colloidon and animal membrane.
- the device of claim 1 including a tubular member connected to said membrane and adapted to transmit a second fluid through said passage While the tissue that defines said passage receives anesthetic through said membrane.
- said tube is sized to transmit life-supporting quantities of air into the lungs of a patient, and said membrane forms an inflatable annulus about said tube, whereby said annulus can form a seal between the tube and the tissue of said passage while simultaneously applying surface-effective anesthetic to said tissue.
- the device of claim 5 wherein said device is an endotracheal tube adapted to be inserted through the mouth, into the trachea of a patient, said tube having an external end adapted for connection to means for introducing air into the patient, said annulus having an outer 6 diameter, when distended, sized to fill the internal diameter of the trachea.
- the device of claim 1 comprising a suppository sized to be inserted into the anus of a patient and havinga membrane wall exposed to engage the tissue of the anus, thereby to anesthetize the painful tissue resulting from a hemorrhoidectomy.
- the device of claim 7 including an enlarged flexible outer wall member for location outside the anus, to contain the fluid anesthetic, a passage adapted to transmit the anesthetic inwardly to inward wall portions, thereby to supply anesthetic to the painful tissue.
- the device of claim 8 including an inwardly en-Inventged member, arranged to position the device.
Description
Oct. 24, 1967 R. R. JACKSON 3,348Q542 ANESTHETIC ARTICLES Q I Filed Dec. 2, 1964 2 Sheets-Sheet 1 Oct. 24, 1967 v I R. R. JACKSON I 3,343,542
ANESTHETIC ARTICLES Filed Dec. 2, 19 4 4 I Z-Sheets-Sheet z:
United States Patent 3,348,542 ANESTHETIC ARTICLES Richard R. Jackson, 54 Dwight St., Brookline, Mass. 02146 Filed Dec. 2, 1964, Ser. No. 415,326 9 Claims. (Cl. 128-184) ABSTRACT OF THE DISCLOSURE A surfaceetfective anesthetic applicator for body pas sages. It includes a flexible, fluid-tight membrane that has a diffusion characteristic for the anesthetic. The membrane forms part of an inflatable container and the fluid anesthetic can both distend the wall into tissue contact and apply anesthetic to that tissue by diffusion.
Also this applicator combined with a tube to transmit another fluid through the passage while the passage wall receives anesthetic. Advantageously the tube ventilates the lungs, and the membrane forms a seal between the tube and the wall of the passage, to prevent escape of air. Also this applicator formed as a suppository.
This invention relates to the administration of anesthetics. I
One object of the invention is to provide an improved means for administering surface effective anesthetics to body tissue. A more particular object is to provide a means for making a patient more comfortable during the treatment of body cavities and passages, and especially while mechanical devices such as tubes are inserted.
Another object of the invention is to provide improved mechanical devices for insertion into body passages and cavities.
Another object of the invention is to provide means for better controlling the administration of surface effective anesthetics. A more particular object is to enable administration over a controllable prolonged period, for instance a number of hours, or even a half day or longer. Another object is to enable administration at controllable dosage rates and total dosages. Still another object is to provide means which permits a better correlation between dosage rate of surface effective anesthetics and the observable effects of prior dosage.
A still further object of the invention is to provide, in combination with mechanical devices, means to administer surface effective anesthetics over a prolonged period in a manner that does not harm body tissue and improves the use of the mechanical devices.
Specific objects of the invention are to provide improved tracheal tube devices and improved suppositories.
According to the invention I have realized that a membrane member can be used to contain a fluid surfaceeifective anesthetic, and can produce a progressive release at proper rate to tissues of the body in contact with the membrane. By this means extremely prolonged surface anesthesia of tissue can be achieved. Such a membrane device combined with a mechanical device enables use of the latter over a prolonged period without pain.
I The invention takes advantage of the impeded diffusion characteristic of membrane material, with the rate of release controlled by the selection of the membrane as well as by the conditions of the fluid itself.
Many materials may be fashioned into such a membrane. Included are cellophane, which incidentally is quite durable and is presently preferred, colloidon, silicone rubber, latex and animal membranes such as intestine walls. Selection of the membrane depends upon the char acteristics of the particular anesthetic fluid. Thus with a water solution anesthetic, which is preferred, cellophane is a very good membrane, and the dosage rate can be 3,348,542 Patented Oct. 24, 1967 controlled by thickness. Colloidon and animal membranes can also be use-d. For certain anesthetics, e.g. containing alcohol, more impedance may be acceptable, making rubberous materials useful; Alternatively, membrane materials may be specially treated, e.g. punctured with small holes, to vary their characteristics. One treatment is to stretch a rubberous sheet and puncture it with needles which may be heated or shaped to remove rubber from the hole. Another treatment is to subject a rubberous sheet to electrical particles such as high energy electrons, or to an excessive electric field which can produce small holes in the sheet.
In the drawings:
FIG. 1 is a side view of one preferred embodiment of the device of the invention;
FIG. 2 is a median section view of a human being illustrating the use of the device of FIG. 1;
FIG. 3 is a view similar to FIG. 2 of another preferred embodiment of the invention;
FIG. 4 is a side view, partially in cross-section, of another preferred embodiment of the invention;
FIG. 5 is a view showing the endotracheal tube of FIG 4 inserted in the trachea of a patient.
Referring to FIG. 1 a tube 10 of diameter D of flexi ble membrane material'is knotted at both ends 12, 14 defining a bag. A resilient tube 16, of smaller diameter D and of greater stiffness than the walls of tube 10 is disposed within the bag, at one end 14. By ties 18 and 20 the bag is drawn against the tube 16, forming pleats in the bag. Holes 22 and 24 are provided in the tube on either side of the tie 18, enabling the part of the bag hugging the tube to receive liquid from the large end of the bag. The bag is filled with liquid surface-effective anesthetic 26, the membrane and anesthetic properties cooperatively related to enable anesthetic to be released through the membrane at an effective dosage rate. A bag 28 for instance in the form of a rubber prophylactic article, surrounds this entire assembly, and is tied off, at 30.
In use the large end of the tube 10 serves as a stop. preventing further inward movement of the device. This end also serves as a supply. The resilient bag 28, in the stretched position shown in FIG. 2, serves to maintain pressure upon the bag to assist movement of the anesthetic. It also serves to cover the large end of the membrane bag, preventing loss of anesthetic from that region.
During use the anesthetic need neither be discharged in a short time nor contained completely. Rather, by virtue ofv the impeded diffusion characteristic of the membrane relative to the anesthetic, a dosage rate can be maintained at a substantially effective level and body tissue in contact with the membrane can be thereby continually anesthetized.
EXAMPLE 1 A rectal suppository such as shown in FIG. 1 was made and filled with surface-effective anesthetic. For this purpose a .2 inch length of 1 inch diameter cellophane tube, having a wall thickness of .002 inch, was knotted at one end at 12, was filled with 20 cc. of 2% water base liquid Xylocaine (trademark of Astra Pharmaceutical Products, Inc., Worcester, Mass. for lidocaine hydrochloride, Patent No. 2,441,498).
The tube 16 was used for filling, in this instance comprising arubber tube of OD. and wall thickness. It was inserted in the open end of the cellophane tube and this open end was tied securely about the rubber tube at 18 and 20. I I
The cellophane tube employed was conventional Weck Sterilizing tubing furnished to hospitals by the Edward Weck & Co., division of Sterling Precision Corp. 4933 is regenerated cellulose plasticized with glycerol, and lubricated with neutral white oil.
After filling, the cellophane tube 10 was tied off at 14, fully enclosing the rubber tube.
The suppository was inserted into the patient following hemorrhoid surgery, in the position shown in FIG. 2. Insertion was facilitated by the relative stiffness of the rubber tube 16.
The patient rested comfortably without need of narcotics for more than six hours before feeling pain. This was the result of administration of the anesthetic by means of the membrane wall of the suppository.
The suppository caused no injury to the tissue.
In contrast, with customary procedures the patient feel intense pain and is administered 8-10 mg. of morphine every three to four hours, for the first 24 hours following surgery.
The effectiveness of the suppository can be prolonged by limiting the membrane area to that contacting the surgical area tissue. This can be accomplished by entirely or partially occluding the remainder of the walls, for instance by making those walls thicker or applying a coating such as rubber, or by means of the bag 28 as shown in FIG. 2. Various controls for the dosage rate of anesthetic are made possible by the device. At first there is the possibility of selection of the kind and concentration of the anesthetic and the membrane material. After a membrane material is selected, e.g. cellophane, then its thickness can be selected. For instance a .004" wall thickness can transmit a lighter, though effective, dose than a wall of .002. Then, during use, the amount of pressure upon the anesthetic can be adjusted, depending upon observation of the patient, and as well, the temperature of the anesthetic can be adjusted, increase in either increasing the dosage rate.
In addition to the liquid anestheic, other rectal drugs may be administrated through the membrane. For instance to the 20 millimeters of 2% lidocaine hydrochloride of Example 1, a concentration of 1 to 100,000 epinephrine can be added. This will promote hemostasis (stop bleeding) and will conserve the anesthetic due to its effect of constricting the blood vessels and thus limiting the rate at which blood carries away the anesthetic.
Referring to FIG. 3 there is shown a rectal suppository in the form of a dumbbell. Preferably each end of the dumbbell is formed of membrane material, filled with surface-effective anesthetic and adapted to administer the anesthetic according to the invention.
The large size of the ends 32 and 34 of the dumbbell serve as stops, preventing inward or outward movement.
Advantageously at least the inner end 34 is formed by a plurality of concentric membrane bags 35, 36, 37, 38. In each space defined between a pair of these bags is held a fraction of the total charge of surface effective anesthetic. This fraction can be sized so that, in the event of accidental rupture of the outer wall 35, for instance, the sudden release of the amount of surface effective anesthe-tic to the body is limited to what the body can easily tolerate. For instance, each of the spaces can be filled with 6 cc. of 4% liodocaine hydrochloride.
Furthermore, the plurality of bag walls increase the impedance to travel of anesthetic from the center of the bag, and thus serve to prolong the anesthetic effect of the device and control the dosage rate.
The device is easily formed from a single tube by knotting, filling, knotting the open end, passing the tube over the filled portion, filling the space in between from the other end, knotting at the other end, and so on.
In some cases it is advantageous to fill a central bag, e.g. 38, with water or other neutral agent, and to make that bag wall of imprevious material. Thus the over-all size of the device can be increased without increasing the amount of anesthetic being used.
Referring to the embodiment of FIGS. 4 and 5 an endotracheal tube 42 is provided having a cuff 40.
The tube 42 can be of conventional design, defining an air passage that extends from the fitting 44 at the exterior end to the interior end. This tube is adapted to be connected to a ventilator to supply air to the lungs of a patient and to exhaust air from the lungs. The tube is formed of resilient material such as heavy rubber.
The cuff 40 is located close to the interior end in the conventional manner. It surrounds the tube 42, defining an annular container, i.e., a short length sheath. It is more flexible than the tube 42. A relatively small supply tube 46 extends from the cuff for inflation purposes.
According to the invention the tissue contacting wall 48 of the cuff 40 is constructed and arranged as a membrane having a diffusion characteristic enabling an effective dosage rate of surface-effective liquid anesthetic 49 to pass through the wall to the tissue of the trachea.
EXAMPLE 2 A conventional endotracheal tube was modified by removing the conventional relatively thick walled rubber cuff and aflixing a cuff formed of membrane material. In this instance the cuff was formed of the cellophane described in Example 1, tied at 41 and 43 to the tube 42.
The cellophane was folded to hug tightly the outer surface of the endotracheal tube 42, and the tube was inserted through the mouth of the patient. Once in place liquid anesthetic (2% lidocaine hydrochloride) was introduced through supply tube 46 to the cuff 40 causing the cuff to inflate and engage a ring of tracheal tissue 47, thus creating a seal.
While the lungs of the patient were ventilated by means of the tube 42, the anesthetic was progressively applied to the contacting tracheal tissue at an effective dosage due to the impeding diffusion characteristic of the membrane.
This anesthetized the tissue and made the patient much more comfortable than is the normal case, using a conventional tube with only spray-application of anesthetic prior to placing the tube in the trachea.
Use of the endotracheal cuff described permits tolerance of an endotracheal tube by the awake patient. Many times patients weakened by surgery are unable to breath adequately following surgery, and will succumb from asphyxia if not assisted in the act of breathing. Ordinarily the endotracheal tube used during the operation is left in place after the patient returns to consciousness. The endotracheal tube produces violent coughing however, very similar to the reaction a person has when he inhales a peanut into his wind-pipe. A patient reacting thusly cannot be assisted effectively in the act of breathing. Use of the embodiment of FIGS. 4 and 5 however averts this difficulty, for his tracheal tissue will not detect the presence of the tube. One filling with 6-10 cc. of 2% lidocaine hydrochloride will last around 10-12 hours.
Among the surface effective anesthetic drugs that are suitable for use are the following: Lidocaine 14%, Tetracaine 02-05%, Dyclonine 0.51%, Diothane 1%, Hexylcaine 5%, Cocaine 35% solution. Lidocaine 2% in volumes of 10-20 cc. is presently the preferred agent.
Containers formed with walls of diffusion impeding membranes, filled with any of these surface effective anesthetic agents, may be inserted in body openings or surgical incisions and will provide effective surface anesthesia for 8-12 hours.
What is claimed is:
1. An applicator device sized and shaped to removably enter a body opening and lie in a body passage, said device including a highly flexible, distensible, thin wall exposed to contact surface tissue that defines the body passage, the wall comprising a generally fluid-tight membrane having a diffusion characteristic for diffusion of surface-effective fluid anesthetic through its thickness, said wall being sealed to form at least a part of an inflatable container adapted to receive surface-effective fluid anesthetic, whereby the yieldable pressure of the fluid anesthetic introduced to said container itself can distend the wall into an intimately conforming tissue-contacting relationship to apply anesthetic to that tissue by diffusion.
2. The device of claim 1 wherein said membrane is selected from the group consisting of cellophane, colloidon and animal membrane.
3. The device of claim 1 wherein said wall has a thickness of the order of magnitude of .004 inch.
4. The device of claim 1 including a tubular member connected to said membrane and adapted to transmit a second fluid through said passage While the tissue that defines said passage receives anesthetic through said membrane.
5. The device of claim 4 wherein said tube is sized to transmit life-supporting quantities of air into the lungs of a patient, and said membrane forms an inflatable annulus about said tube, whereby said annulus can form a seal between the tube and the tissue of said passage while simultaneously applying surface-effective anesthetic to said tissue.
6. The device of claim 5 wherein said device is an endotracheal tube adapted to be inserted through the mouth, into the trachea of a patient, said tube having an external end adapted for connection to means for introducing air into the patient, said annulus having an outer 6 diameter, when distended, sized to fill the internal diameter of the trachea.
7. The device of claim 1 comprising a suppository sized to be inserted into the anus of a patient and havinga membrane wall exposed to engage the tissue of the anus, thereby to anesthetize the painful tissue resulting from a hemorrhoidectomy.
8. The device of claim 7 including an enlarged flexible outer wall member for location outside the anus, to contain the fluid anesthetic, a passage adapted to transmit the anesthetic inwardly to inward wall portions, thereby to supply anesthetic to the painful tissue.
9. The device of claim 8 including an inwardly en- Iarged member, arranged to position the device.
References Cited UNITED STATES PATENTS 2,099,127 11/1937 Leech 128-208 2,756,742 7/1956 Barton 128-208 2,847,997 8/1958 Tibone 128260 3,275,001 9/1966 Rosecrans 128349 ADELE M. EAGER, Primary Examiner.
Claims (1)
1. AN APPLICATOR DEVICE SIZED AND SHAPED TO REMOVABLY ENTER A BODY OPENING AND LIE IN A BODY PASSAGE, SAID DEVICE INCLUDING A HIGHLY FLEXIBLE, DISTENSIBLE, THIN WALL EXPOSED TO CONTACT SURFACE TISSUE THAT DEFINES THE BODY PASSAGE, THE WALL COMPRISING A GENERALLY FLUID-TIGHT MEMBRANE HAVING A DIFFUSION CHARACTERISTIC FOR DIFFUSION OF SURFACE-EFFECTIVE FLUID ANESTHETIC THROUGH ITS THICKNESS, SAID WALL BEING SEALED TO FORM AT LEAST A PART OF AN INFLATABLE CONTAINER ADAPTED TO RECEIVE SURFACE-EFFECTIVE FLUID ANESTHETIC, WHEREBY THE YIELDABLE PRESSURE OF THE FLUID ANESTHETIC INTRODUCED TO SAID CONTAINER ITSELF CAN DISTEND THE WALL INTO AN INTEMATELY CONFORMING TISSUE-CONTACTING RELATIONSHIP TO APPLY ANESTHETIC TO THAT TISSUE BY DIFFUSION.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US415326A US3348542A (en) | 1964-12-02 | 1964-12-02 | Anesthetic articles |
GB50748/65A GB1133728A (en) | 1964-12-02 | 1965-11-30 | Improvements in or relating to endotracheal tubes |
DK617465AA DK115657B (en) | 1964-12-02 | 1965-12-01 | Endotracheal anesthesia apparatus. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US415326A US3348542A (en) | 1964-12-02 | 1964-12-02 | Anesthetic articles |
Publications (1)
Publication Number | Publication Date |
---|---|
US3348542A true US3348542A (en) | 1967-10-24 |
Family
ID=23645255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US415326A Expired - Lifetime US3348542A (en) | 1964-12-02 | 1964-12-02 | Anesthetic articles |
Country Status (3)
Country | Link |
---|---|
US (1) | US3348542A (en) |
DK (1) | DK115657B (en) |
GB (1) | GB1133728A (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3505999A (en) * | 1967-08-25 | 1970-04-14 | Old Westport Medical Ass Inc | Earplug |
US3610247A (en) * | 1969-03-03 | 1971-10-05 | Richard R Jackson | Surface-anesthetizing medical appliance |
US3817248A (en) * | 1972-11-06 | 1974-06-18 | Alza Corp | Self powered device for delivering beneficial agent |
US3854484A (en) * | 1971-10-22 | 1974-12-17 | R Jackson | Endotracheal tube with liquid fillable cuff |
US3981299A (en) * | 1971-03-15 | 1976-09-21 | Harry Elmer Murray | Urethral catheter |
US4417576A (en) * | 1982-02-25 | 1983-11-29 | Baran Ostap E | Double-wall surgical cuff |
US4471776A (en) * | 1980-12-08 | 1984-09-18 | Cox Everard F | Static tracheostomy tube |
US4979505A (en) * | 1989-06-06 | 1990-12-25 | Cox Everard F | Tracheal tube |
US5042476A (en) * | 1989-08-10 | 1991-08-27 | Smith Charles A | Endotracheal tube protection arrangement |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5702384A (en) * | 1992-02-28 | 1997-12-30 | Olympus Optical Co., Ltd. | Apparatus for gene therapy |
US5797877A (en) * | 1993-10-01 | 1998-08-25 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
US6132824A (en) * | 1989-09-25 | 2000-10-17 | Schneider (Usa) Inc. | Multilayer catheter balloon |
US6896842B1 (en) | 1993-10-01 | 2005-05-24 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
US20070066962A1 (en) * | 2005-09-21 | 2007-03-22 | Rutter Michael J | Airway Balloon Dilator |
US20080167608A1 (en) * | 2005-09-21 | 2008-07-10 | Rutter Michael John | Balloon dilator |
CN108135736A (en) * | 2015-07-31 | 2018-06-08 | 新加坡科技研究局 | For being inserted into the device of body cavity and its manufacturing method |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3766927A (en) * | 1971-10-22 | 1973-10-23 | R Jackson | Hydraulic cuff tracheal tube |
US3799173A (en) * | 1972-03-24 | 1974-03-26 | J Kamen | Tracheal tubes |
DE19638935C1 (en) * | 1996-09-10 | 1998-03-26 | Fred G Goebel | Tracheal tube providing fluid seal |
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US2099127A (en) * | 1936-12-30 | 1937-11-16 | Foregger Co Inc | Pharyngeal bulb gasway |
US2756742A (en) * | 1953-08-18 | 1956-07-31 | Barton Foundation | Endotracheal tongue blade with tube guide |
US2847997A (en) * | 1956-01-13 | 1958-08-19 | James J Tibone | Catheter |
US3275001A (en) * | 1962-05-22 | 1966-09-27 | Kendall & Co | Self-inflatable catheter |
-
1964
- 1964-12-02 US US415326A patent/US3348542A/en not_active Expired - Lifetime
-
1965
- 1965-11-30 GB GB50748/65A patent/GB1133728A/en not_active Expired
- 1965-12-01 DK DK617465AA patent/DK115657B/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US2099127A (en) * | 1936-12-30 | 1937-11-16 | Foregger Co Inc | Pharyngeal bulb gasway |
US2756742A (en) * | 1953-08-18 | 1956-07-31 | Barton Foundation | Endotracheal tongue blade with tube guide |
US2847997A (en) * | 1956-01-13 | 1958-08-19 | James J Tibone | Catheter |
US3275001A (en) * | 1962-05-22 | 1966-09-27 | Kendall & Co | Self-inflatable catheter |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3505999A (en) * | 1967-08-25 | 1970-04-14 | Old Westport Medical Ass Inc | Earplug |
US3610247A (en) * | 1969-03-03 | 1971-10-05 | Richard R Jackson | Surface-anesthetizing medical appliance |
US3981299A (en) * | 1971-03-15 | 1976-09-21 | Harry Elmer Murray | Urethral catheter |
US3854484A (en) * | 1971-10-22 | 1974-12-17 | R Jackson | Endotracheal tube with liquid fillable cuff |
US3817248A (en) * | 1972-11-06 | 1974-06-18 | Alza Corp | Self powered device for delivering beneficial agent |
US4471776A (en) * | 1980-12-08 | 1984-09-18 | Cox Everard F | Static tracheostomy tube |
US4417576A (en) * | 1982-02-25 | 1983-11-29 | Baran Ostap E | Double-wall surgical cuff |
US4979505A (en) * | 1989-06-06 | 1990-12-25 | Cox Everard F | Tracheal tube |
US5042476A (en) * | 1989-08-10 | 1991-08-27 | Smith Charles A | Endotracheal tube protection arrangement |
US6132824A (en) * | 1989-09-25 | 2000-10-17 | Schneider (Usa) Inc. | Multilayer catheter balloon |
US6482348B1 (en) | 1991-04-26 | 2002-11-19 | Boston Scientific Corporation | Method of forming a co-extruded balloon for medical purposes |
US5195969A (en) * | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US7585289B2 (en) | 1991-04-26 | 2009-09-08 | Boston Scientific Scimed, Inc. | Co-extruded medical balloon |
US6136258A (en) * | 1991-04-26 | 2000-10-24 | Boston Scientific Corporation | Method of forming a co-extruded balloon for medical purposes |
US5702384A (en) * | 1992-02-28 | 1997-12-30 | Olympus Optical Co., Ltd. | Apparatus for gene therapy |
US6086556A (en) * | 1993-10-01 | 2000-07-11 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
US6896842B1 (en) | 1993-10-01 | 2005-05-24 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
US5797877A (en) * | 1993-10-01 | 1998-08-25 | Boston Scientific Corporation | Medical device balloons containing thermoplastic elastomers |
US7781038B2 (en) | 1993-10-01 | 2010-08-24 | Boston Scientific Scimed, Inc. | Medical device balloons containing thermoplastic elastomers |
US20070066962A1 (en) * | 2005-09-21 | 2007-03-22 | Rutter Michael J | Airway Balloon Dilator |
US20070066961A1 (en) * | 2005-09-21 | 2007-03-22 | Rutter Michael J | Airway balloon dilator |
US20080167608A1 (en) * | 2005-09-21 | 2008-07-10 | Rutter Michael John | Balloon dilator |
US7591830B2 (en) | 2005-09-21 | 2009-09-22 | Rutter Michael John | Airway balloon dilator |
CN108135736A (en) * | 2015-07-31 | 2018-06-08 | 新加坡科技研究局 | For being inserted into the device of body cavity and its manufacturing method |
US20190000668A1 (en) * | 2015-07-31 | 2019-01-03 | Agency For Science, Technology And Research | Device for insertion into a body cavity, and method of fabrication thereof |
US10932946B2 (en) * | 2015-07-31 | 2021-03-02 | Agency For Science, Technology And Research | Device for insertion into a body cavity, and method of fabrication thereof |
EP3328332B1 (en) * | 2015-07-31 | 2022-03-23 | Agency for Science, Technology And Research | Device for insertion into a body cavity, and method of fabrication thereof |
Also Published As
Publication number | Publication date |
---|---|
DK115657B (en) | 1969-10-27 |
GB1133728A (en) | 1968-11-13 |
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