US3411503A - Collapsible mixing syringe with extrusion casing - Google Patents

Collapsible mixing syringe with extrusion casing Download PDF

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US3411503A
US3411503A US560642A US56064266A US3411503A US 3411503 A US3411503 A US 3411503A US 560642 A US560642 A US 560642A US 56064266 A US56064266 A US 56064266A US 3411503 A US3411503 A US 3411503A
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case
plunger
bellows
syringe unit
cup
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Louis S Santomieri
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall

Definitions

  • a syringe for medical use, comprising a bellows-type collapsible body containing a diluent and disposed in a case on which a hypodermic needle may be mounted in communication with said body, and a plunger in the case finger-movable in a direction to collapse the body; the plunger including means containing a soluble medicament initially separate from the diluent but which means releases the medicament into the body for mixture with the diluent upon such movement of the plunger prior to mounting of the hypodermic needle on said body.
  • This invention relates in general to an improved syringe unit adapted for medical use in connection with an initially separate hypodermic needle.
  • the invention is directed to, and it is a major object to provide, a novel syringe unit wherein from the time of manufacture to the time of usea dry but soluble medicament and a diluent are maintained in sterile, enclosed and separated relation; the medicament being released into the diluent by a simple manipulation of the syringe unit.
  • the resultant solution is thus prepared in a quick and ready manner for use and without any possible exposure to contamination.
  • Such syringe unit is especially adapted for use with those medicaments which are required to be or are preferably placed in solution only shortly before use.
  • Another important object of the invention is to provide a syringe unit, as above, which includes a collapsible body containing the diluent and a cup on the body containing the dry but soluble medicament; there being a rupturable membrane between the cup and body and the cup opening into communication with the body upon rupture of said membrane caused by forceful, manual collapse of the body.
  • An additional important object of the invention is to provide a syringe unit which includes a collapsible body of substantially cylindrical, bellows-type form, and a protective substantially cylindrical, open-bottom case in which the bellows-type body is enclosed; the body having a plunger at the bottom, and the case having inside diameters such that the plunger is desirably radially free when in its initial and lowermost position but closely slidably guided in the case when pushed upwardly during use of the syringe unit.
  • a further object of the invention is to provide a syringe unit which is designed for ease and economy of manufacture.
  • a still further object of the invention is to provide a practical, reliable, and durable syringe unit and one which is exceedingly effective for the purpose for which it is designed.
  • FIG. 1 is a front elevation of the syringe unit, with the double-ended needle shown in position for attachment to said unit-
  • FIG. 2 is a sectional elevation of the syringe unit; the view being taken on line 22 of FIG. 1.
  • FIG. 3 is a rear elevation of the syringe unit.
  • FIG. 4 is a bottom plan of the same.
  • the syringe unit comprises a vertically elongated, cylindrical case 1 having a top 2; such case being full open at the bottom as shown.
  • the case 1 is formed with a longitudinal notch 3 open at its lower end to the bottom of the case; such notch 3 terminating adjacent but short of the top 2 of said case 1.
  • a somewhat elongated slot 4 At the back of the case 1 is provided with a somewhat elongated slot 4. The notch 3 and slot 4 are for the purpose of permitting finger access into case 1 as will hereinafter appear.
  • a vertically elongated, collapsible body 5 of cylindrical, bellows-type form is disposed within the confines of case 1; the body 5 including a top 6 permanently sealed to the underside of the top 2 of case 1.
  • An internally threaded neck 7 is mounted centrally on and opens through the top 2; the throat 8 of the neck being closed at its inner end by a puncturable membrane 9.
  • the syringe unit is provided with a removable screw plug 10 threaded into the neck 7 from its outer end.
  • the bellows-type body 5, before use of the syringe unit, is fully expanded and is then of a length somewhat less than the case 1; the bottom 11 of said body 5 being permanently sealed to the topside of a circular plunger 12 having a depending annular skirt 13.
  • the plunger 12 and skirt 13 form, in effect, a piston-like member on the lower end of the bellows-type body 5 and which member is disposed wholly within the case.
  • the skirt 13 has a downwardly opening, substantially semi-circular finger notch 14 therein which is symmetrical to and registers in the main with the vertically elongated notch 3 in case 1.
  • the circular plunger 12 is formed with a central, depending cup 15 closed at the top by a rupturable membrane 16 whichuntil rupturedprevents communication and provides a seal between said cup 15 and the interior of the bellows-type body 5.
  • cup 15 depends from the plunger 12, such cup serves as a central push button adapted for engagement from below by a finger projected laterally into the syringe unit through the notches 3 and 14.
  • the cup 15 contains a quantity of a dry but soluble medicament?17 which does not quite fill the cup and so that, as shown, a small void remains below the rupturable membrane 16.
  • the bellows-type body 5 is filled with a sterile diluent which remains separate from the medicament 17 as long as membrane 16 is unruptured.
  • the syringe unit When the syringe unit is in its manufactured or initial condition, with the cup 15 holding the medicament 17 and the bellows-type body 5 filled with a sterile diluent, said body is fully expanded and the skirted plunger 12 occupies a position in the lower portion of the cylindrical case 1.
  • Such lower portion of the case has a bore 18 whose inside diameter is greater than the outside diameter of said skirted plunger 12; the bore 18 extending to a point above said plunger. Consequently, the bellows-type body 5 can freely expand (due to temperature or atmospheric variation) and without the skirted plunger binding in the case. This is an important feature as it prevents accidental rupturing of membrane 16 by undue pressure increase in the body 5.
  • the bore 19 thereof is reduced in diameter to an extent sufiicient to receive the skirted plunger 12 in close but relatively slidable, guided relation.
  • Such injection of the solution is accomplished by removing the screw plug 10 and replacing it with the screw plug 20 of a double-ended hypodermic needle 21 of standard type.
  • the inner end portion of needle 21 punctures the membrane 9 and passes into the upper part of the bellows-type body 5.
  • the skirted plunger 12 is pressed into the guiding bore 19 of the case and slowly advanced by finger pressure against the bottom of cup 15; the finger as before-extending through notches 3 and 14.
  • the bellows-type body 5 is shortened and the -solution therein is fed through the needle 21 in a measured quantity indicated by a scale 22 marked exteriorly on case 1 adjacent the vertically elongated notch 3, and on which scale the plunger reads.
  • the pre-filled syringe unit of the present invention is quick to use (important in an emergency), wholly avoids the necessity of filling the syringe at the time of use, and assures of a sterile solution for injection.
  • a syringe unit comprising a cylindrical case having a top, a cylindrical bellows-type body disposed in the case, the upper end of the bellows-type body being secured in sealed relation to the top of the case, means on the top of the case adapted to receive and support a hypodermic needle in communication with the interior of the bellows-type body, a plunger on the lower end of the bellows-type body, the case being formed to provide finger access to said plunger, a cup formed in the plunger and facing into the bellows-type body, and a pressure rupturable membrane closing the cup against communication with the interior of said body; the cup containing a soluble medicament, and the bellows-type body being filled with a diluent.
  • a syringe unit as in claim 1, in which the cup depends from the plunger to provide a push button, the plunger being skirted, there being a finger notch in the skirt, and an elongated finger notch in the case; such notches being in register.
  • a syringe unit as in claim 1, in which the lower portion of the bore of the case is of reater inside diameter than the diameter of the plunger, the plunger initially being disposed in said lower portion of the bore of the case, and the upper portion of the bore of the case being of a diameter to receive the plunger in close but relatively slidable, guided relation.
  • a syringe unit as in claim 1, in which the case is formed with an elongated finger notch, the plunger being visible and accessible through such finger notch, and scale markings lengthwise on the case adjacent the finger notch.

Description

Nov. 19, 1968 L. s. SANTOMIERI 3,411,503
COLLAPSIBLE MIXING SYRINGE WITH EXTRUSION CASING Filed June 27, 1966 llllllllllllll INVENTOR. v 100/: .S 54/V70M/EE/ 43M raw United States Patent 3,411,503 COLLAPSIBLE MIXING SYRINGE WITH EXTRUSION CASING Louis S. Santomieri, Vallejo, Calif. (345 W. M St., Benicia, Calif. 94510) Filed June 27, 1966, Ser. No. 560,642 4 Claims. (Cl. 128216) ABSTRACT OF THE DISCLOSURE A syringe, for medical use, comprising a bellows-type collapsible body containing a diluent and disposed in a case on which a hypodermic needle may be mounted in communication with said body, and a plunger in the case finger-movable in a direction to collapse the body; the plunger including means containing a soluble medicament initially separate from the diluent but which means releases the medicament into the body for mixture with the diluent upon such movement of the plunger prior to mounting of the hypodermic needle on said body.
This invention relates in general to an improved syringe unit adapted for medical use in connection with an initially separate hypodermic needle.
In particular, the invention is directed to, and it is a major object to provide, a novel syringe unit wherein from the time of manufacture to the time of usea dry but soluble medicament and a diluent are maintained in sterile, enclosed and separated relation; the medicament being released into the diluent by a simple manipulation of the syringe unit. The resultant solution is thus prepared in a quick and ready manner for use and without any possible exposure to contamination. Such syringe unit is especially adapted for use with those medicaments which are required to be or are preferably placed in solution only shortly before use.
Another important object of the invention is to provide a syringe unit, as above, which includes a collapsible body containing the diluent and a cup on the body containing the dry but soluble medicament; there being a rupturable membrane between the cup and body and the cup opening into communication with the body upon rupture of said membrane caused by forceful, manual collapse of the body.
An additional important object of the invention is to provide a syringe unit which includes a collapsible body of substantially cylindrical, bellows-type form, and a protective substantially cylindrical, open-bottom case in which the bellows-type body is enclosed; the body having a plunger at the bottom, and the case having inside diameters such that the plunger is desirably radially free when in its initial and lowermost position but closely slidably guided in the case when pushed upwardly during use of the syringe unit.
A further object of the invention is to provide a syringe unit which is designed for ease and economy of manufacture.
A still further object of the invention is to provide a practical, reliable, and durable syringe unit and one which is exceedingly effective for the purpose for which it is designed.
These objects are accomplished by means of such structure and relative arrangement of parts as will fully appear by a. perusal of the following specification and claims.
In the drawings:
FIG. 1 is a front elevation of the syringe unit, with the double-ended needle shown in position for attachment to said unit- FIG. 2 is a sectional elevation of the syringe unit; the view being taken on line 22 of FIG. 1.
FIG. 3 is a rear elevation of the syringe unit.
FIG. 4 is a bottom plan of the same.
Referring now more particularly to the drawings and to the characters of reference marked thereon, the syringe unit comprises a vertically elongated, cylindrical case 1 having a top 2; such case being full open at the bottom as shown.
At the front, the case 1 is formed with a longitudinal notch 3 open at its lower end to the bottom of the case; such notch 3 terminating adjacent but short of the top 2 of said case 1. At the back of the case 1 is provided with a somewhat elongated slot 4. The notch 3 and slot 4 are for the purpose of permitting finger access into case 1 as will hereinafter appear.
A vertically elongated, collapsible body 5 of cylindrical, bellows-type form is disposed within the confines of case 1; the body 5 including a top 6 permanently sealed to the underside of the top 2 of case 1.
An internally threaded neck 7 is mounted centrally on and opens through the top 2; the throat 8 of the neck being closed at its inner end by a puncturable membrane 9. For transport or shelf storage, the syringe unit is provided with a removable screw plug 10 threaded into the neck 7 from its outer end.
The bellows-type body 5, before use of the syringe unit, is fully expanded and is then of a length somewhat less than the case 1; the bottom 11 of said body 5 being permanently sealed to the topside of a circular plunger 12 having a depending annular skirt 13. The plunger 12 and skirt 13 form, in effect, a piston-like member on the lower end of the bellows-type body 5 and which member is disposed wholly within the case.
At the front, the skirt 13 has a downwardly opening, substantially semi-circular finger notch 14 therein which is symmetrical to and registers in the main with the vertically elongated notch 3 in case 1.
The circular plunger 12 is formed with a central, depending cup 15 closed at the top by a rupturable membrane 16 whichuntil rupturedprevents communication and provides a seal between said cup 15 and the interior of the bellows-type body 5.
As the cup 15 depends from the plunger 12, such cup serves as a central push button adapted for engagement from below by a finger projected laterally into the syringe unit through the notches 3 and 14.
The cup 15 contains a quantity of a dry but soluble medicament?17 which does not quite fill the cup and so that, as shown, a small void remains below the rupturable membrane 16. The bellows-type body 5 is filled with a sterile diluent which remains separate from the medicament 17 as long as membrane 16 is unruptured.
When the syringe unit is in its manufactured or initial condition, with the cup 15 holding the medicament 17 and the bellows-type body 5 filled with a sterile diluent, said body is fully expanded and the skirted plunger 12 occupies a position in the lower portion of the cylindrical case 1. Such lower portion of the case has a bore 18 whose inside diameter is greater than the outside diameter of said skirted plunger 12; the bore 18 extending to a point above said plunger. Consequently, the bellows-type body 5 can freely expand (due to temperature or atmospheric variation) and without the skirted plunger binding in the case. This is an important feature as it prevents accidental rupturing of membrane 16 by undue pressure increase in the body 5.
Above the lower portion of the case, the bore 19 thereof is reduced in diameter to an extent sufiicient to receive the skirted plunger 12 in close but relatively slidable, guided relation.
The above described syringe unit is used in the following manner:
With the syringe unit in hand, one finger is extended through the notches 3 and 14 and into engagement with the bottom of cup 15; the latter then being forcefully pressed upward. This rapidly increases the pressure in the bellows-type body whereupon the membrane 16 ruptures, the diluent gains access to cup and the medicament 17 therein, and by then shaking the syringe unit the medicament passes into solution in the diluent and is ready for hypodermic injection.
Such injection of the solution is accomplished by removing the screw plug 10 and replacing it with the screw plug 20 of a double-ended hypodermic needle 21 of standard type. As the screw plug 20 is threaded into neck 7, the inner end portion of needle 21 punctures the membrane 9 and passes into the upper part of the bellows-type body 5. Thereafter, with the outer end portion of needle 21 medically inserted, the skirted plunger 12 is pressed into the guiding bore 19 of the case and slowly advanced by finger pressure against the bottom of cup 15; the finger as before-extending through notches 3 and 14. As the plunger is so advanced, the bellows-type body 5 is shortened and the -solution therein is fed through the needle 21 in a measured quantity indicated by a scale 22 marked exteriorly on case 1 adjacent the vertically elongated notch 3, and on which scale the plunger reads.
Under certain conditions, it is necessary to partially expand or lengthen the bellows-type body 5 after the skirted plunger 12 has been advanced. This is done by placing fingers through both the front notch 3 and rear slot 4, and then engaging and applying a light force to the bellows-type body 5 in a direction to expand or lengthen it.
The pre-filled syringe unit of the present invention is quick to use (important in an emergency), wholly avoids the necessity of filling the syringe at the time of use, and assures of a sterile solution for injection.
From the foregoing description, it will be readily seen that there has been produced such a syringe unit as substantially fulfills the objects of the invention, as set forth herein.
While this specification sets forth in detail the present and preferred construction of the syringe unit, still in practice such deviations from such detail may be resorted to as do not form a departure from the spirit of the invention, as defined by the appended claims.
Having thus described the invention, the following is claimed as new and useful and upon which Letters Patent is desired:
1. A syringe unit comprising a cylindrical case having a top, a cylindrical bellows-type body disposed in the case, the upper end of the bellows-type body being secured in sealed relation to the top of the case, means on the top of the case adapted to receive and support a hypodermic needle in communication with the interior of the bellows-type body, a plunger on the lower end of the bellows-type body, the case being formed to provide finger access to said plunger, a cup formed in the plunger and facing into the bellows-type body, and a pressure rupturable membrane closing the cup against communication with the interior of said body; the cup containing a soluble medicament, and the bellows-type body being filled with a diluent.
2. A syringe unit, as in claim 1, in which the cup depends from the plunger to provide a push button, the plunger being skirted, there being a finger notch in the skirt, and an elongated finger notch in the case; such notches being in register.
3. A syringe unit, as in claim 1, in which the lower portion of the bore of the case is of reater inside diameter than the diameter of the plunger, the plunger initially being disposed in said lower portion of the bore of the case, and the upper portion of the bore of the case being of a diameter to receive the plunger in close but relatively slidable, guided relation.
4. A syringe unit, as in claim 1, in which the case is formed with an elongated finger notch, the plunger being visible and accessible through such finger notch, and scale markings lengthwise on the case adjacent the finger notch.
References Cited UNITED STATES PATENTS 2,129,119 9/1938 Davis 222 2,676,591 4/1954 Fox 1282l6 2,717,598 9/1955 Krasno 128-216 3,340,869 9/1967 Bane 128--216 3,351,058 11/1967 Webb 128272 FOREIGN PATENTS 294,187 7/ 19.28 Great Britain.
RICHARD A. GAUDET, Primary Examiner.
M. MAJESTIC, Assistant Examiner.
US560642A 1966-06-27 1966-06-27 Collapsible mixing syringe with extrusion casing Expired - Lifetime US3411503A (en)

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Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496937A (en) * 1967-05-18 1970-02-24 John E Balson Hypodermic syringe
US4823815A (en) * 1986-09-19 1989-04-25 Mentor Corporation Tissue expanding device and method of making same
US4921142A (en) * 1985-09-14 1990-05-01 Ing. Erich Pfeiffer Gmbh & Co. Kg Manually operable fluid dispenser
US4950237A (en) * 1987-11-06 1990-08-21 Merck & Co., Inc. Dual chambered mixing and dispensing vial
US5002206A (en) * 1989-10-25 1991-03-26 Merck & Co., Inc. Double tip drug dispensing and metering device
US5019048A (en) * 1990-01-10 1991-05-28 Margolin George D Unit dose syringe with rotatable needle
US5217433A (en) * 1991-05-24 1993-06-08 Merck & Co., Inc. Medication container for mixing two components
US5257726A (en) * 1985-08-14 1993-11-02 Ing. Erich Pfeiffer Gmbh & Co. Kg Dispenser for flowable media
US5308322A (en) * 1993-04-19 1994-05-03 Tennican Patrick O Central venous catheter access system
US5320845A (en) * 1993-01-06 1994-06-14 Py Daniel C Apparatus for delivering multiple medicaments to an eye without premixing in the apparatus
US5613957A (en) * 1991-12-02 1997-03-25 Daniel Py Apparatus for applying medicament to an eye
USRE37047E1 (en) 1992-04-06 2001-02-06 Daniel Py Cartridge for applying medicament to an eye from a dispenser
US6544213B1 (en) 1999-09-13 2003-04-08 Merck & Co., Inc. Dual compartment mixing and dispensing device
US20040026459A1 (en) * 2000-09-21 2004-02-12 Bernard Clerget Gripping device for flexible bag dispenser
US20070244467A1 (en) * 2005-09-28 2007-10-18 Biodel, Inc., State Of Incorporation Delaware Self-Filling Two Chamber Injectable Device
US20120085782A1 (en) * 2009-06-26 2012-04-12 System Communications, Inc. Holder for flexible pouch container
US20130043273A1 (en) * 2009-09-09 2013-02-21 Kist-Europe Forschungsgesellschaft Mbh Metering device for the metered dispension of fluid preparations, and methods related thereto
US9180252B2 (en) 2012-04-20 2015-11-10 Bayer Medical Care Inc. Bellows syringe fluid delivery system
US9498570B2 (en) 2010-10-25 2016-11-22 Bayer Healthcare Llc Bladder syringe fluid delivery system
US10046106B2 (en) 2010-10-25 2018-08-14 Bayer Healthcare Llc Bladder syringe fluid delivery system
US10583256B2 (en) 2014-04-25 2020-03-10 Bayer Healthcare Llc Syringe with rolling diaphragm
US10933190B2 (en) 2015-04-24 2021-03-02 Bayer Healthcare Llc Syringe with rolling diaphragm
US11207462B2 (en) 2016-10-17 2021-12-28 Bayer Healthcare Llc Fluid injector with syringe engagement mechanism
US11389585B2 (en) 2016-09-16 2022-07-19 Bayer Healthcare Llc Pressure jacket having syringe retaining element
US11547793B2 (en) 2016-10-17 2023-01-10 Bayer Healthcare Llc Fluid injector with syringe engagement mechanism
US11826541B2 (en) 2017-09-13 2023-11-28 Bayer Healthcare Llc Sliding syringe cap for separate filling and delivery
US11839751B2 (en) 2020-06-18 2023-12-12 Bayer Healthcare Llc In-line air bubble suspension apparatus for angiography injector fluid paths
US11918775B2 (en) 2019-09-10 2024-03-05 Bayer Healthcare Llc Pressure jackets and syringe retention features for angiography fluid injectors
US11938093B2 (en) 2020-02-21 2024-03-26 Bayer Healthcare Llc Fluid path connectors for medical fluid delivery

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Publication number Priority date Publication date Assignee Title
GB294187A (en) * 1927-04-20 1928-07-20 Arthur Cyril Hutt Improvements in or relating to collapsible containers
US2129119A (en) * 1936-12-16 1938-09-06 Davis Charles Extrusion container
US2676591A (en) * 1951-03-27 1954-04-27 Fox Dorothy Brown Hypodermic unit
US2717598A (en) * 1952-11-21 1955-09-13 Louis R Krasno Hypodermic syringe
US3340869A (en) * 1963-08-08 1967-09-12 Bane Arthur Collapsible ampoules
US3351058A (en) * 1965-07-12 1967-11-07 Amco Capital Corp Two compartment medical injector

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB294187A (en) * 1927-04-20 1928-07-20 Arthur Cyril Hutt Improvements in or relating to collapsible containers
US2129119A (en) * 1936-12-16 1938-09-06 Davis Charles Extrusion container
US2676591A (en) * 1951-03-27 1954-04-27 Fox Dorothy Brown Hypodermic unit
US2717598A (en) * 1952-11-21 1955-09-13 Louis R Krasno Hypodermic syringe
US3340869A (en) * 1963-08-08 1967-09-12 Bane Arthur Collapsible ampoules
US3351058A (en) * 1965-07-12 1967-11-07 Amco Capital Corp Two compartment medical injector

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496937A (en) * 1967-05-18 1970-02-24 John E Balson Hypodermic syringe
US5257726A (en) * 1985-08-14 1993-11-02 Ing. Erich Pfeiffer Gmbh & Co. Kg Dispenser for flowable media
US4921142A (en) * 1985-09-14 1990-05-01 Ing. Erich Pfeiffer Gmbh & Co. Kg Manually operable fluid dispenser
US4823815A (en) * 1986-09-19 1989-04-25 Mentor Corporation Tissue expanding device and method of making same
US4950237A (en) * 1987-11-06 1990-08-21 Merck & Co., Inc. Dual chambered mixing and dispensing vial
US5002206A (en) * 1989-10-25 1991-03-26 Merck & Co., Inc. Double tip drug dispensing and metering device
US5019048A (en) * 1990-01-10 1991-05-28 Margolin George D Unit dose syringe with rotatable needle
US5217433A (en) * 1991-05-24 1993-06-08 Merck & Co., Inc. Medication container for mixing two components
US5613957A (en) * 1991-12-02 1997-03-25 Daniel Py Apparatus for applying medicament to an eye
US5685869A (en) * 1991-12-02 1997-11-11 Daniel Py Apparatus for applying medicament to an eye
US5944702A (en) * 1991-12-02 1999-08-31 Instill & Co. Method for instilling a predetermined volume of medicament into an eye
USRE37047E1 (en) 1992-04-06 2001-02-06 Daniel Py Cartridge for applying medicament to an eye from a dispenser
US5320845A (en) * 1993-01-06 1994-06-14 Py Daniel C Apparatus for delivering multiple medicaments to an eye without premixing in the apparatus
US5308322A (en) * 1993-04-19 1994-05-03 Tennican Patrick O Central venous catheter access system
US6544213B1 (en) 1999-09-13 2003-04-08 Merck & Co., Inc. Dual compartment mixing and dispensing device
US6932247B2 (en) * 2000-09-21 2005-08-23 Rexam Dispensing Systems Gripping device for flexible bag dispenser
US20040026459A1 (en) * 2000-09-21 2004-02-12 Bernard Clerget Gripping device for flexible bag dispenser
US20070244467A1 (en) * 2005-09-28 2007-10-18 Biodel, Inc., State Of Incorporation Delaware Self-Filling Two Chamber Injectable Device
US20120085782A1 (en) * 2009-06-26 2012-04-12 System Communications, Inc. Holder for flexible pouch container
US20130043273A1 (en) * 2009-09-09 2013-02-21 Kist-Europe Forschungsgesellschaft Mbh Metering device for the metered dispension of fluid preparations, and methods related thereto
US10835680B2 (en) 2010-10-25 2020-11-17 Bayer Healthcare Llc Bladder syringe fluid delivery system
US9498570B2 (en) 2010-10-25 2016-11-22 Bayer Healthcare Llc Bladder syringe fluid delivery system
US10046106B2 (en) 2010-10-25 2018-08-14 Bayer Healthcare Llc Bladder syringe fluid delivery system
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