Búsqueda Imágenes Maps Play YouTube Noticias Gmail Drive Más »
Iniciar sesión
Usuarios de lectores de pantalla: deben hacer clic en este enlace para utilizar el modo de accesibilidad. Este modo tiene las mismas funciones esenciales pero funciona mejor con el lector.

Patentes

  1. Búsqueda avanzada de patentes
Número de publicaciónUS3433226 A
Tipo de publicaciónConcesión
Fecha de publicación18 Mar 1969
Fecha de presentación21 Jul 1965
Fecha de prioridad21 Jul 1965
Número de publicaciónUS 3433226 A, US 3433226A, US-A-3433226, US3433226 A, US3433226A
InventoresCharles A Boyd
Cesionario originalAeroprojects Inc
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet
Vibratory catheterization apparatus and method of using
US 3433226 A
Resumen  disponible en
Imágenes(1)
Previous page
Next page
Reclamaciones  disponible en
Descripción  (El texto procesado por OCR puede contener errores)

5 12&- 3 1:

March 18, 1969 c. A. BOYD 3,433,226

VIBRATORY CATHETERIZATION APPARATUS AND METHOD OF USING Filed July 21, 1965 w n y 7 2o 22 et! I a INVENTOI? CHARLES A. BOYD ATTORNEYS.

.-.cludingscoronary atherosclerosis.

United States Patent 3,433,226 VIBRATORY CATHETERIZATION APPARATUS AND METHOD OF USING Charles A. Boyd, West Chester, Pa.,'assignor to Aeroprojects Incorporated, West Chester, Pa., a corporation of Pennsylvania Filed July 21, 1965, Ser. No. 473,596 US. Cl. 128-305 Int. Cl. A61b 17/32; A6111 1/00; A6lm 25/00 Claims ABSTRACT OF THE DISCLOSURE This invention relates to the use of ultrasonic energy for therapeutic purposes, and more particularly to a therapeuticvmethod and apparatus for such purposes as localization and yibratory treatment of irculatioy blocking ..L9 2i 1:@9 z inatieassiiiifi A 4; those occurring in various types of a cl rosis in:

It has been suggested heretofore to use ultrasonic energy in treating patients having subdeltoid bursitis with the energy reportedly being externally applied through the a skin over the affected area via a liquid petrolatum coupling agent, using an intensity of preferably 0.5 watt/ C1132:

ar 1d a maximum of 1.5 watts/cm The ul'fras'onic en e-rgy produces a powerful and deep micromassage, exerts localized thermal action, and increases interacellular me tabolism; it causes exud-ates and precipitates to be absorbed and tissue deposits to be broken up; it loosens tissue, relieves edema, decreases liypertonicity of the muscle, and produces a local analgesia causing an immediate relief of pain. (Page 73, The Indication and Contraindications for Ultrasonic Therapy in Medicine" by J. H. Aldes, in Ultrasound in Biology and Medicine, American Institute of Biological Sciences, Washington. DC, Publication No. 3, 1957) It is to be noted that in this bursitis experimentation, the externally applied ultrasonic energy was ineffective in 52. percent of the cases in decreasing or eliminating calcareous deposit. It has also been suggested (page 161, Ultrasonic Technology by Richard G. Goldman, New York: Reinhold Publishing Corp., 1962): r

It is interesting also to speculate on the possibility of inserting a small transducer into the stomach or heart, which can then irradiate gall stones or calcinations at close range with localized effect.

Moreover, at page l6l of the July-September 1964 3,433,226 Patented Mar. 18 1969 issue (vol. 2) of Ultrasonics, in a Letter to the Editor, there was reported an unsuccessful attempt to apply ultrasonic energy with the end object of emulsifying atherom atous material while leaving the strong fibrous coat of the artery intact or re-boring atheromaobstructed arteries too small for conventional endarterectomy. Thus, postmortem specimens of arteries affected by various degrees. of atheroma were irradiated in water with ultrasound for at least 30 minute periods at frequencies of 20 kc. and l mc. using 50 and 60 watts of power with piezoelectric crystals, and also at 13 kc. using up to 100 watts of power with an industrial magnetostrictive transducer. There was no obvious effect whatever in the 13 kc. experiments, and the only macroscopic effect in the 20 kc. and 1 mc. experiments was co'agulation partly due to "heat.

In other work, a commercial general-purpose apparatus (advertised to enable production of a widerange of effects in chemistry, biology, pharmacology, metallurgy, etc.) was impractical for blood vessel decalcification. Touching a solid acoustical coupling member probe (part of an. ultrasonic apparatus having a design frequency of 20 kc.' and a maximum average output of watts) to atheromatous placques for 15-20 seconds resulted in decimation of the placques; however, there was shearing of the silver braze joint joining the probe to the remainder of the apparatus. Further experiments, with a catenoidal coupling .mem-ber attached to the same basic apparatus, with an in--*- p'u't'to the transducer of 9 watts (power level), readily cleared atheromatous material from cadaver coronary vessels but, after one minute of ultrasonic energy application, tissue heating with destruction of specimens was often apparent.

The present invention overcomes the disadvantages of the prior art and indicates that tissue heating can be eliminated by using a hollow internally cooled catheter. Excellent results on atheromatous aorta tissue were 'obtained by passing ambient saline or a low molecular weight dextran solution through the probe. 0n cadaver coronary vessels, the atheromata was reduced to micron size particles using a power level of 2.6 watts. Said par ticles can then be flushed away by use of a dextran solution.

It is an object of .the present invention to provide novel apparatus and method for vibratory catheterization.

It is another object of the present invention to provide an ultrasonic catheter for internal therapeutic purposes.

It is a further object of the present invention to provide a catheter for decimation of atheromatous placques without hetiting tissues or destruction of specimens.

Another object of the present invention is to provide apparatus for Treatment of coronary artery disease by u sonic coronary endarterectomy.

For the purpose of illustrating the invention there is shown in the drawings a form which is presently preferred, it being understood, however, that this invention is not limited to the precise arrangements and instrumentalitie's shown.

FIGURE 1 is a sectional view of a catheter.

FIGURE 2 is a sectional view of the tip end of another embodiment.

FIGURE 3 is a sectional view of the tip end of another embodiment.

Referring to the drawings, wherein like reference characters refer to like parts, there is shown'in FIGURE 1 an ultrasonic catheter generally designated as 10.

The catheterlg is essentially an ultrasonic transducercoupling system comprising an ult rasonic transducer 12, an acoustical coupling member 14, another acoustical coupling member 16, and a third acoustical coupling member 18 having an end face or tip 20. Member 18 is hollow and metallurgically joined to merriber 14 in line with passageway 22. Passageway 23 intersects passageway 22. Conduit 24 is connected to member 14 in passageway 23.

Catheter is designed to operate at a given frequency, which is preferably a resonant frequency. Catheter 10 is preferably dimensioned to have an over-all physical length equivalent to an acoustical length of a whole number multiple of one-half wavelength in the material of which it is made at the said frequency (see FIGURE 1 wherein "n" indicates a whole number). For efficient operation, there is an antinode (loop) area of the vibration at the end face 20.

Transducer 12 may be of the magnetostrictive type as shown and of conventional construction comprising a half-wavelength long laminated core of nickel, nickel-iron alloy, or other magnetostrietive material, properly dimensioned to insure axial resonance with the frequency of alternatlng current applied thereto by coil 1 -1 so as to cause it to increase or decrease in length according to its coefiicient of magnetostriction. The detailed construction of a suitable magnetostrietive transducer is well known to those skilled in the art and does not form a part of the present invention and, accordingly, no description of its construction will be made herein. It will be appreciated by those skilled in the art that in place of the magnetostrictive transducer 12 other known types of transducers may be substituted; for example, an electrostrictive or piezoelectric transducer made of bariuriftitar'iate, quartz crystals, lead zirconate titanate, etc., may be utilized.

Transducer 12 is provided with an excitation coil '11 and a polarizing coil 13. Excitation coil 11 is connected to a power supply (incorporating an amplifier, not shown, and oscillator, not shown) suitable for powering the transducer 12; such equipment is well known to the art. The desirability of magnetically polarizing the magnetostrictive transducer 12 by means of polarizing coil 13, in order for the metal laminations in said transducer to efiiciently convert the applied energy from excitation coil 11 into elastic vibratory energy, is also readily understood by those skilled in the art. Low voltage direct current can be supplied to coil 13 by battery, rectifier, or other means well known to the art.

The aforesaid power supply system, in a typical example, is capable of producing electrical signals in the range of between about 60 cycles per second and about 300,000 cycles per second. This frequency range is suitable for purposes of the present invention, including as it does frequencies in both the audible range (such as up to about 15,000 cycles per second) and the ultrasonic range (generally above about 15,000 cycles per second). A preferred frequency would be in the range of from about 3,000 to about 50,000 cycles per second with the optimum being between about 14,000 to about 35,000 cycles per second. Normally, a frequency is chosen which will provide a suitable size of apparatus for a given application or set of applications, with the ultrasonic range having the further advantage of inaudibility for operator comfort.

Thus, catheter transducer-coupling system 10 may be constructed to operate at 28,000 cycles per second, for example. In an embodiment of FIGURE 1, a 100 watt power supply was used to drive a transducer 12 at said 28 kc. design frequency.

As is well known to the art, the electrical frequency of the alternating current power supply (sirch as 60 cycles per second) is changed to match the mechanical or elastic vibratory frequency of the transducer (28,000 cycles per second in this example, as aforesaid).

The member 18 is preferably semi-flexible and can be curved within certain limits established by the acoustic characteristics to facilitate manipulation. Preferably, the curvature of the member 18 has a bend ra'dius which is at least x/4 wherein X is the wavelength of the material of member 18. The reason for this limitation on the bend radius is set forth rnore clearly in Patent 3,166,840.

'A coolant fluid may be introduced through conduit 24 and passageway 2]. to cop] the member 18, to irrigate tis sue in the vicinity of the tip 20, and flush away any micron sized particles resulting from decimation of placques. A low molecular weight dextran solution at a temperature of from about ambient temperature to body temperature may be pumped through the system at low pressure. The solution exits through the tip 20. The micron sized particles of the placques result from the physical effect of the vibrating catheter tip 20 upon calcified atheromata.

Sterilization of the catheter can be accomplished utilizing conventional sterilization equipment. If desired, the member 18 may be provided with removable tips which can be disposable. In order to facilitate sterilization or autoclaving, and simultaneously facilitate manipulation of the catheter with minimum power losses, a force-insensitive mount 15 is provided. One end of mount 15 is metallurgically joined to the coupling member 14. The other end of mount 15 is free. The mount 15 is provided with a radially outwardly directed flange 17. Flange 17 is joined to a housing 25 with a waterproof joint. Housing 25 may constitute a handle and is preferably of sufiicient length so as to encase the transducer 12 as shown. Suitable plug-in connections 27, 27' can be provided hermetically sealed to the housing 25 for electrically connecting to the coils 11 and 13, and to facilitate autoclaving the catheter.

A force-insensitive mount may comprise a sleeve such as the described in US. Patents 2,891,178; 2,891,179; and

2,891,180. The disclosures of such patents are incorporated herein by reference. Such a mount facilitates the application of force necessary to insert the catheter into a cavity, artery, or the like. The sleeve is made from a metal such as steel or any other suitable resonant material and has a length equal to a single one-half wavelength. The sleeve surrounds 'the coupler 14 and is concentric therewith and spaced therefrom.

The flange 17 is spaced from the free end of mount 15 by an acoustical distance corresponding to one-quarter wavelength according to the properties of the mount and the desired frequency of operation. The mount 15 when so constructed .will cause a true node of vibratory energy to be developed in the flange 17 so that no vibratory energy will be transmitted to the housing 25.

The operable usage of the ultrasonic endarterectomy catheter requires that a reliable source of vibratory energy be coupled to the working tip 20 having a diameter of the order of a millimeter. The members 16 and 18 may have a length of around 18 inches. To prevent temperature build-up and thereby minimize thermal damage to the tissue, a cooling system as described above is required.

The vibrational energy generated by the transducer can be coupled to the members 16 and 18 in several different modes. The first and simplest mode is that of longitudinal vibration, as shown, wherein the particle displacements occur in a direction parallel to the axis of members 16 and 18. A second mode of vibration is that of lateral or transverse vibration wherein particle displacements occur in a direction normal to the axis of members 16 and 18. This results in an excursion of the tip 20 parallel to the plane of the end face thereof. Other more complicated modes including torsional vibration wherein the system oscillates periodically in torsion about its own axis, or a radial vibration wherein the end tip 20 periodically ex= pands and contracts radially may be utilized.

The exact mechanism by which the placques of the calcified atheromata are destroyed is not well understood. The nature of the mechanism will depend in part on the physical characteristics of the vibrating tip. Several tip geometries may be employed where desired: In FIGURE 1, the geometry of the removable tip 20 is a square edge. As shown more clearly in FIGURE 2, the tip 20 remov= ably mounted on a coupling member 18' may have a chisel edge defined by an internal beveled surface 26. In FIGURE 2, the beveled surface 26 provides a sharp cut ting edge at the periphery.

A third type of tip is illustrated in FIGURE 3. Tip 20' removably mounted on coupling member 18" is in 53 bulbous form, The bulb 28 may be either metal or plastic. The purpose of bulb 28 is to provide a more positive contact between the working surface of the catheter and the tissue being treated. The surface of bulb 28 may have an abrasive character. The tips of FIGURES 2 and 3 may be substituted for the tip 20' in FIGURE 1.

The method steps and conditions for practicing the present invention for treatment of disease or other conditions for therapeutic purposes is considered to be suf ficiently known to those skilled in the art so as not to require a detailed explanation. Using the known principle of oxygen in solution, at 3 atmospheres positive pressure ischemia induced by introducing the catheter by way of the coronary ostia can be prevented. The flow of coolant, such as low molecular weight dextran, can replace oxygenated blood for long periods and prevent a means of oxygenation to the myocardium.

The present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof and, accordingly, reference should be made to the appended claims rather than to the foregoing specification as indicating the scope of the invention,

It is claimed:

1. A catheter comprising a transducer means for gen erating vibratory energy, a resonant coupling member having one end connected to said transducer and a tip at its other end. the end of said tip being at an anti-node on said member, said member having an acoustical length of a whole number multiple of one-half wavelength in the material of which it is made at the frequency of said transducer means, and said member being partially hol= low with the hollow portion beginning at said tip, whereby a liquid for cooling said member may be pumped through said portion for discharge through said tip.

2. A catheter in accordance with claim 1 including a housing, said member being hermetically sealed to said housing with said transducer means disposed within said housing.

3. A catheter in accordance with claim 1 wherein said 6 transducer means is axially coupled to said member for vibrating said member in a direction corresponding to the longitudinal axis of said member.

4. A catheter in accordance with claim 1 wherein said tip has an end face which is substantially perpendicular to the longitudinal axis of said member. F

5. A catheter in accordance with claim 1 wherein said tip is bulbous.

6. A catheter in accordance with claim 1 wherein said tip has an internal beveled face providing a sharp-edge at the periphery of the tip.

7. A catheter in accordance with claim 1 wherein said coupling member has a length of approximately 18 inches and a diameter along a substantial length thereof beginning at the tip of approximately 1 millimeter.

8. A method comprising the steps of transmitting acoustical vibratory energy from a transducer means through a resonant coupling member at least a portion of which is hollow beginning from a tip end of said coupling member designed to have an anti-node at the end face of the tip, introducing a coolant through said portion for dis-' charge through said tip, and transmitting the vibratory energy from the tip to a living animal by contacting the portion of the animal with said tip.

References Cited UNITED STATES PATENTS 2,230,997 2/1941 Chambers et al. 2,407,690 9/1946 Southworth. 3,358,677 12/1967 Sheldon 128-24 FOREIGN PATENTS 540,428 4/1922 France. 991,494 6/ 1951 France.

L. W. TRAPP, Primary Examiner.

US. Cl. X.R. HS-24, 348

Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
US2230997 *23 Dic 193711 Feb 1941Univ PennsylvaniaMethod of extracting constituents of living cells
US2407690 *16 May 194117 Sep 1946Bell Telephone Labor IncWave guide electrotherapeutic system
US3358677 *23 Oct 196419 Dic 1967Sheldon Edward EmanuelSupersonic therapeutic device with means for introducing fluid into a body cavity
FR540428A * Título no disponible
FR991494A * Título no disponible
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US3565062 *13 Jun 196823 Feb 1971Ultrasonic SystemsUltrasonic method and apparatus for removing cholesterol and other deposits from blood vessels and the like
US3570476 *18 Nov 196816 Mar 1971David Paul GreggMagnetostrictive medical instrument
US3636943 *27 Oct 196725 Ene 1972Ultrasonic SystemsUltrasonic cauterization
US3823717 *16 Abr 197316 Jul 1974Pohlman RApparatus for disintegrating concretions in body cavities of living organisms by means of an ultrasonic probe
US3908637 *22 Abr 197430 Sep 1975Louis W DoroshowRigid urethral instrument
US4188952 *12 Sep 197819 Feb 1980Loschilov Vladimir ISurgical instrument for ultrasonic separation of biological tissue
US4269176 *24 Nov 197826 May 1981Siemens AktiengesellschaftTreatment head for electromedical diagnostic or therapeutic treatment of body parts
US4504264 *24 Sep 198212 Mar 1985Kelman Charles DApparatus for and method of removal of material using ultrasonic vibraton
US4526571 *15 Oct 19822 Jul 1985Cooper Lasersonics, Inc.Curved ultrasonic surgical aspirator
US4531934 *21 Dic 198230 Jul 1985Gorkovsky Gosudarstvenny Meditsinsky Institute Imini S.M. KirovaApparatus for the fragmentation and aspiration of ocular tissue
US4561438 *17 Dic 198431 Dic 1985Richard Wolf GmbhPiezoelectric transducer with curved shafts
US4650466 *1 Nov 198517 Mar 1987Angiobrade PartnersAngioplasty device
US4750488 *27 Feb 198714 Jun 1988Sonomed Technology, Inc.Vibration apparatus preferably for endoscopic ultrasonic aspirator
US4750902 *19 May 198614 Jun 1988Sonomed Technology, Inc.Endoscopic ultrasonic aspirators
US4808153 *17 Nov 198628 Feb 1989Ultramed CorporationDevice for removing plaque from arteries
US4832683 *15 Jul 198623 May 1989Sumitomo Bakellite Company LimitedSurgical instrument
US4921484 *25 Jul 19881 May 1990Cordis CorporationMesh balloon catheter device
US4922902 *16 Dic 19878 May 1990Valleylab, Inc.Method for removing cellular material with endoscopic ultrasonic aspirator
US4931038 *2 Dic 19875 Jun 1990Gipharmex S.P.A.Complex of products for the rapid and not-invasive treatment of biliary calculosis
US4962755 *21 Jul 198916 Oct 1990Heart Tech Of Minnesota, Inc.Method for performing endarterectomy
US4982730 *21 Dic 19888 Ene 1991Lewis Jr Royce CUltrasonic wound cleaning method and apparatus
US5058570 *27 Nov 198622 Oct 1991Sumitomo Bakelite Company LimitedUltrasonic surgical apparatus
US5084010 *20 Feb 199028 Ene 1992Devices For Vascular Intervention, Inc.System and method for catheter construction
US5127917 *17 May 19907 Jul 1992Schneider (Europe) A.G.Probe, especially for the recanalization of occlusions, and catheter arrangement with such a probe
US5269291 *10 Dic 199014 Dic 1993Coraje, Inc.Miniature ultrasonic transducer for plaque ablation
US5304115 *11 Ene 199119 Abr 1994Baxter International Inc.Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5324255 *10 Jul 199228 Jun 1994Baxter International Inc.Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5334183 *9 Abr 19922 Ago 1994Valleylab, Inc.Endoscopic electrosurgical apparatus
US5342292 *24 May 199330 Ago 1994Baxter International Inc.Ultrasonic ablation device adapted for guidewire passage
US5344395 *24 Ene 19926 Sep 1994Scimed Life Systems, Inc.Apparatus for intravascular cavitation or delivery of low frequency mechanical energy
US5368557 *5 May 199329 Nov 1994Baxter International Inc.Ultrasonic ablation catheter device having multiple ultrasound transmission members
US5368558 *3 Jun 199329 Nov 1994Baxter International Inc.Ultrasonic ablation catheter device having endoscopic component and method of using same
US5380274 *12 Oct 199310 Ene 1995Baxter International Inc.Ultrasound transmission member having improved longitudinal transmission properties
US5382228 *28 Sep 199317 Ene 1995Baxter International Inc.Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5390678 *12 Oct 199321 Feb 1995Baxter International Inc.Method and device for measuring ultrasonic activity in an ultrasound delivery system
US5397301 *19 Jul 199314 Mar 1995Baxter International Inc.Ultrasonic angioplasty device incorporating an ultrasound transmission member made at least partially from a superelastic metal alloy
US5405318 *28 Sep 199311 Abr 1995Baxter International Inc.Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5417672 *4 Oct 199323 May 1995Baxter International Inc.Connector for coupling an ultrasound transducer to an ultrasound catheter
US5423797 *25 Abr 199413 Jun 1995Medelex, Inc.Acoustic catheter with rotary drive
US5427118 *4 Oct 199327 Jun 1995Baxter International Inc.Ultrasonic guidewire
US5443443 *17 Ago 199322 Ago 1995Surgical Systems & Instruments, Inc.Atherectomy system
US5447509 *4 Oct 19935 Sep 1995Baxter International Inc.Ultrasound catheter system having modulated output with feedback control
US5474530 *8 Jun 199412 Dic 1995Baxter International Inc.Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasospasm
US5480379 *4 Oct 19932 Ene 1996La Rosa; AntonioUltrasonic dissector and detacher for atherosclerotic plaque and method of using same
US5490859 *29 Abr 199313 Feb 1996Scimed Life Systems, Inc.Expandable intravascular occlusion material removal devices and methods of use
US5501694 *3 Mar 199426 Mar 1996Scimed Life Systems, Inc.Expandable intravascular occlusion material removal devices and methods of use
US5549601 *11 Oct 199427 Ago 1996Devices For Vascular Intervention, Inc.Delivery of intracorporeal probes
US5725494 *30 Nov 199510 Mar 1998Pharmasonics, Inc.Apparatus and methods for ultrasonically enhanced intraluminal therapy
US5728062 *30 Nov 199517 Mar 1998Pharmasonics, Inc.Apparatus and methods for vibratory intraluminal therapy employing magnetostrictive transducers
US5735811 *30 Nov 19957 Abr 1998Pharmasonics, Inc.Apparatus and methods for ultrasonically enhanced fluid delivery
US5792157 *30 Sep 199611 Ago 1998Scimed Life Systems, Inc.Expandable intravascular occlusion material removal devices and methods of use
US5810859 *28 Feb 199722 Sep 1998Ethicon Endo-Surgery, Inc.Apparatus for applying torque to an ultrasonic transmission component
US5836868 *25 Mar 199617 Nov 1998Scimed Life Systems, Inc.Expandable intravascular occlusion material removal devices and methods of use
US5846218 *5 Sep 19968 Dic 1998Pharmasonics, Inc.Balloon catheters having ultrasonically driven interface surfaces and methods for their use
US5897567 *9 Sep 199727 Abr 1999Scimed Life Systems, Inc.Expandable intravascular occlusion material removal devices and methods of use
US5919186 *8 May 19976 Jul 1999Bath; Patricia E.Laser apparatus for surgery of cataractous lenses
US5931805 *2 Jun 19973 Ago 1999Pharmasonics, Inc.Catheters comprising bending transducers and methods for their use
US5968060 *28 Feb 199719 Oct 1999Ethicon Endo-Surgery, Inc.Ultrasonic interlock and method of using the same
US5989274 *20 Dic 199623 Nov 1999Ethicon Endo-Surgery, Inc.Methods and devices for improving blood flow to a heart of a patient
US5989275 *28 Feb 199723 Nov 1999Ethicon Endo-Surgery, Inc.Damping ultrasonic transmission components
US6001069 *1 May 199814 Dic 1999Ekos CorporationUltrasound catheter for providing a therapeutic effect to a vessel of a body
US6030212 *27 Sep 199629 Feb 2000Dentsply Research & Development Corp.Stacking reservoir and scaler system
US6083192 *14 Feb 19974 Jul 2000Bath; Patricia E.Pulsed ultrasound method for fragmenting/emulsifying and removing cataractous lenses
US6135976 *25 Sep 199824 Oct 2000Ekos CorporationMethod, device and kit for performing gene therapy
US61712657 Ene 19989 Ene 2001Storz Endoskop GmbhHandpiece for use with a multifunctional operating endoscopic instrument
US617684221 Sep 199823 Ene 2001Ekos CorporationUltrasound assembly for use with light activated drugs
US62103565 Ago 19983 Abr 2001Ekos CorporationUltrasound assembly for use with a catheter
US622103827 Nov 199624 Abr 2001Pharmasonics, Inc.Apparatus and methods for vibratory intraluminal therapy employing magnetostrictive transducers
US62280463 Mar 19988 May 2001Pharmasonics, Inc.Catheters comprising a plurality of oscillators and methods for their use
US627496331 Ago 199914 Ago 2001Ethicon Endo-Surgery, Inc.Methods and devices for controlling the vibration of ultrasonic transmission components
US62872724 Dic 199811 Sep 2001Pharmasonics, Inc.Balloon catheters having ultrasonically driven interface surfaces and methods for their use
US629379329 Sep 199925 Sep 2001Dentsply Research & Development Corp.Stackable reservoir and scaler system
US631240224 Sep 19986 Nov 2001Ekos CorporationUltrasound catheter for improving blood flow to the heart
US63258115 Oct 19994 Dic 2001Ethicon Endo-Surgery, Inc.Blades with functional balance asymmetries for use with ultrasonic surgical instruments
US63871093 Ago 199914 May 2002Ethicon Endo-Surgery, Inc.Methods and device for improving blood flow to heart of a patient
US643211828 Ago 200013 Ago 2002Ethicon Endo-Surgery, Inc.Multifunctional curved blade for use with an ultrasonic surgical instrument
US646466014 Mar 200115 Oct 2002Pharmasonics, Inc.Balloon catheters having ultrasonically driven interface surfaces and methods for their use
US6482218 *23 Oct 199819 Nov 2002Khanh Vien TranWire-shaped ultrasonic catheter with diamond coated head for ultrasonic angioplasty
US652775920 Jul 20004 Mar 2003Ekos CorporationUltrasound assembly for use with light activated drugs
US668908629 Jul 199910 Feb 2004Advanced Cardiovascular Systems, Inc.Method of using a catheter for delivery of ultrasonic energy and medicament
US672306329 Jun 199820 Abr 2004Ekos CorporationSheath for use with an ultrasound element
US6794369 *9 Ago 200221 Sep 2004PharmasonicsMethods, systems, and kits for intravascular nucleic acid delivery
US692963227 Jun 200216 Ago 2005Advanced Cardiovascular Systems, Inc.Ultrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels
US694267726 Feb 200313 Sep 2005Flowcardia, Inc.Ultrasound catheter apparatus
US695807018 Oct 200125 Oct 2005Witt David ACurved clamp arm tissue pad attachment for use with ultrasonic surgical instruments
US697696914 Ene 200220 Dic 2005Ethicon Endo-Surgery, Inc.Blades with functional balance asymmetries for use with ultrasonic surgical instruments
US713796326 Ago 200221 Nov 2006Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
US71862466 Mar 20036 Mar 2007Ekos CorporationUltrasound catheter with utility lumen
US72202338 Abr 200322 May 2007Flowcardia, Inc.Ultrasound catheter devices and methods
US733518024 Nov 200326 Feb 2008Flowcardia, Inc.Steerable ultrasound catheter
US73844073 Dic 200210 Jun 2008Ekos CorporationSmall vessel ultrasound catheter
US739333016 Feb 20061 Jul 2008Broncus Technologies, Inc.Electrosurgical device having hollow tissue cutting member and transducer assembly
US741355618 Feb 200319 Ago 2008Ekos CorporationSheath for use with an ultrasound element
US742256321 Feb 20029 Sep 2008Broncus Technologies, Inc.Multifunctional tip catheter for applying energy to tissue and detecting the presence of blood flow
US743965424 Feb 200421 Oct 2008Air Products And Chemicals, Inc.Transmission of ultrasonic energy into pressurized fluids
US746216219 Jul 20049 Dic 2008Broncus Technologies, Inc.Antiproliferative devices for maintaining patency of surgically created channels in a body organ
US749446821 Feb 200324 Feb 2009Omnisonics Medical Technologies, Inc.Ultrasonic medical device operating in a transverse mode
US750389524 Feb 200317 Mar 2009Omnisonics Medical Technologies, Inc.Ultrasonic device for tissue ablation and sheath for use therewith
US754085226 Ago 20042 Jun 2009Flowcardia, Inc.Ultrasound catheter devices and methods
US760460814 Ene 200320 Oct 2009Flowcardia, Inc.Ultrasound catheter and methods for making and using same
US762190224 Ago 200624 Nov 2009Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
US762192911 Jul 200524 Nov 2009Flowcardia, Inc.Ultrasound catheter apparatus
US770871219 Jul 20044 May 2010Broncus Technologies, Inc.Methods and devices for maintaining patency of surgically created channels in a body organ
US772717821 Dic 20061 Jun 2010Ekos CorporationCatheter with multiple ultrasound radiating members
US77713725 Ene 200410 Ago 2010Ekos CorporationUltrasonic catheter with axial energy field
US77749334 May 200617 Ago 2010Ekos CorporationMethod of manufacturing ultrasound catheters
US77944149 Feb 200414 Sep 2010Emigrant Bank, N.A.Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes
US782876221 Dic 20069 Nov 2010Ekos CorporationCatheter with multiple ultrasound radiating members
US79144701 Abr 200429 Mar 2011Celleration, Inc.Ultrasonic method and device for wound treatment
US791450915 Feb 200729 Mar 2011Ekos CorporationUltrasound catheter
US795529323 Ago 20067 Jun 2011Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
US797648312 Dic 200312 Jul 2011Ekos CorporationUltrasound assembly with increased efficacy
US799330828 Ene 20059 Ago 2011Ekos CorporationUltrasound enhanced central venous catheter
US800278223 Sep 200523 Ago 2011Ethicon Endo-Surgery, Inc.Curved clamp arm tissue pad attachment for use with ultrasonic surgical instruments
US80432517 Ago 200925 Oct 2011Flowcardia, Inc.Ultrasound catheter and methods for making and using same
US806256625 Jul 200622 Nov 2011Flowcardia, Inc.Method of manufacturing an ultrasound transmission member for use in an ultrasound catheter device
US8083707 *16 Abr 200427 Dic 2011Tosaya Carol ANon-contact damage-free ultrasonic cleaning of implanted or natural structures having moving parts and located in a living body
US81332367 Nov 200613 Mar 2012Flowcardia, Inc.Ultrasound catheter having protective feature against breakage
US81527537 Ago 200910 Abr 2012Flowcardia, Inc.Ultrasound catheter and methods for making and using same
US816783116 Abr 20101 May 2012Ekos CorporationCatheter with multiple ultrasound radiating members
US819236325 Oct 20075 Jun 2012Ekos CorporationCatheter with multiple ultrasound radiating members
US822134320 Ene 200517 Jul 2012Flowcardia, Inc.Vibrational catheter devices and methods for making same
US822656612 Jun 200924 Jul 2012Flowcardia, Inc.Device and method for vascular re-entry
US822662931 Mar 200924 Jul 2012Ekos CorporationUltrasonic catheter power control
US82359197 Abr 20037 Ago 2012Celleration, Inc.Ultrasonic method and device for wound treatment
US824131217 Ago 200514 Ago 2012Ethicon Endo-Surgery, Inc.Blades with functional balance asymmetries for use with ultrasonic surgical instruments
US824664318 Jul 200821 Ago 2012Flowcardia, Inc.Ultrasound catheter having improved distal end
US83086773 Jun 201113 Nov 2012Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
US84091675 Oct 20062 Abr 2013Broncus Medical IncDevices for delivering substances through an extra-anatomic opening created in an airway
US84699827 Abr 201125 Jun 2013Ethicon Endo-Surgery, Inc.Curved clamp arm for use with ultrasonic surgical instruments
US849152117 Jul 200823 Jul 2013Celleration, Inc.Removable multi-channel applicator nozzle
US849666921 Dic 200730 Jul 2013Flowcardia, Inc.Ultrasound catheter having protective feature against breakage
US850651916 Jul 200713 Ago 2013Flowcardia, Inc.Pre-shaped therapeutic catheter
US86087244 Nov 201017 Dic 2013Broncus Medical Inc.Devices for delivering substances through an extra-anatomic opening created in an airway
US861375128 Ene 200824 Dic 2013Flowcardia, Inc.Steerable ultrasound catheter
US86170961 Feb 201131 Dic 2013Flowcardia, Inc.Ultrasound catheter devices and methods
US86230401 Jul 20097 Ene 2014Alcon Research, Ltd.Phacoemulsification hook tip
US86416307 Jul 20104 Feb 2014Flowcardia, Inc.Connector for securing ultrasound catheter to transducer
US864729322 May 200811 Feb 2014Flowcardia, Inc.Therapeutic ultrasound system
US866870925 Feb 200811 Mar 2014Flowcardia, Inc.Steerable ultrasound catheter
US867295921 Jun 201318 Mar 2014Ethicon Endo-Surgery, Inc.Curved clamp arm for use with ultrasonic surgical instruments
US867904917 Jul 201225 Mar 2014Flowcardia, Inc.Device and method for vascular re-entry
US869081821 Dic 20118 Abr 2014Ekos CorporationUltrasound catheter for providing a therapeutic effect to a vessel of a body
US86908199 Nov 20128 Abr 2014Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
US869661227 Mar 201215 Abr 2014Ekos CorporationCatheter with multiple ultrasound radiating members
US870903413 May 201129 Abr 2014Broncus Medical Inc.Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US874083517 Feb 20113 Jun 2014Ekos CorporationTreatment of vascular occlusions using ultrasonic energy and microbubbles
US878440016 May 201222 Jul 2014Broncus Medical Inc.Devices for delivering substances through an extra-anatomic opening created in an airway
US879029122 Abr 200929 Jul 2014Flowcardia, Inc.Ultrasound catheter devices and methods
US879035918 May 200729 Jul 2014Cybersonics, Inc.Medical systems and related methods
US881489528 Jun 201226 Ago 2014Ethicon Endo-Surgery, Inc.Blades with functional balance asymmetries for use with ultrasonic surgical instruments
US885216620 Jun 20127 Oct 2014Ekos CorporationUltrasonic catheter power control
US89323167 Abr 201413 Ene 2015Broncus Medical Inc.Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US895637523 Sep 201117 Feb 2015Flowcardia, Inc.Ultrasound catheter devices and methods
US8961423 *1 Oct 200924 Feb 2015Flowcardia, Inc.Ultrasound catheter apparatus
US90667471 Nov 201330 Jun 2015Ethicon Endo-Surgery, Inc.Ultrasonic surgical instrument blades
US9072565 *19 Jul 20117 Jul 2015W & H Dentalwerk Burmoos GmbhMedical treatment device
US909536722 Oct 20124 Ago 2015Ethicon Endo-Surgery, Inc.Flexible harmonic waveguides/blades for surgical instruments
US917366716 Oct 20123 Nov 2015Med-Sonics CorporationApparatus and methods for transferring ultrasonic energy to a bodily tissue
US919256617 Abr 201424 Nov 2015Ekos CorporationTreatment of vascular occlusions using ultrasonic energy and microbubbles
US919871429 Jun 20121 Dic 2015Ethicon Endo-Surgery, Inc.Haptic feedback devices for surgical robot
US9211137 *28 Jun 201315 Dic 2015Misonix, IncorporatedUltrasonic cutting blade with cooling liquid conduction
US922052728 Jul 201429 Dic 2015Ethicon Endo-Surgery, LlcSurgical instruments
US922676615 Mar 20135 Ene 2016Ethicon Endo-Surgery, Inc.Serial communication protocol for medical device
US922676729 Jun 20125 Ene 2016Ethicon Endo-Surgery, Inc.Closed feedback control for electrosurgical device
US92329796 Feb 201312 Ene 2016Ethicon Endo-Surgery, Inc.Robotically controlled surgical instrument
US923302124 Oct 201312 Ene 2016Alcon Research, Ltd.Phacoemulsification hook tip
US923792115 Mar 201319 Ene 2016Ethicon Endo-Surgery, Inc.Devices and techniques for cutting and coagulating tissue
US924172815 Mar 201326 Ene 2016Ethicon Endo-Surgery, Inc.Surgical instrument with multiple clamping mechanisms
US924173115 Mar 201326 Ene 2016Ethicon Endo-Surgery, Inc.Rotatable electrical connection for ultrasonic surgical instruments
US926552010 Feb 201423 Feb 2016Flowcardia, Inc.Therapeutic ultrasound system
US92829845 Abr 200615 Mar 2016Flowcardia, Inc.Therapeutic ultrasound system
US928304529 Jun 201215 Mar 2016Ethicon Endo-Surgery, LlcSurgical instruments with fluid management system
US932678829 Jun 20123 May 2016Ethicon Endo-Surgery, LlcLockout mechanism for use with robotic electrosurgical device
US93392846 Nov 201217 May 2016Med-Sonics CorporationSystems and methods for controlling delivery of ultrasonic energy to a bodily tissue
US933928918 Jun 201517 May 2016Ehticon Endo-Surgery, LLCUltrasonic surgical instrument blades
US934553211 May 201224 May 2016Broncus Medical Inc.Methods and devices for ablation of tissue
US935175429 Jun 201231 May 2016Ethicon Endo-Surgery, LlcUltrasonic surgical instruments with distally positioned jaw assemblies
US938102723 Dic 20135 Jul 2016Flowcardia, Inc.Steerable ultrasound catheter
US939303729 Jun 201219 Jul 2016Ethicon Endo-Surgery, LlcSurgical instruments with articulating shafts
US940264621 Mar 20142 Ago 2016Flowcardia, Inc.Device and method for vascular re-entry
US940862229 Jun 20129 Ago 2016Ethicon Endo-Surgery, LlcSurgical instruments with articulating shafts
US941485325 Mar 201316 Ago 2016Ethicon Endo-Surgery, LlcUltrasonic end effectors with increased active length
US94152424 Mar 201416 Ago 2016Ekos CorporationCatheter with multiple ultrasound radiating members
US94210247 Mar 201423 Ago 2016Flowcardia, Inc.Steerable ultrasound catheter
US942107018 Dic 201423 Ago 2016Broncus Medical Inc.Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US9427248 *9 Nov 201230 Ago 2016Olympus CorporationUltrasonic probe
US942724910 May 201330 Ago 2016Ethicon Endo-Surgery, LlcRotatable cutting implements with friction reducing material for ultrasonic surgical instruments
US942725025 Ago 201430 Ago 2016Ethicon Endo-Surgery, Inc.Blades with functional balance asymmetries for use with ultrasonic surgical instruments
US943343330 Ene 20146 Sep 2016Flowcardia, Inc.Connector for securing ultrasound catheter to transducer
US943966815 Mar 201313 Sep 2016Ethicon Endo-Surgery, LlcSwitch arrangements for ultrasonic surgical instruments
US943966928 Mar 201313 Sep 2016Ethicon Endo-Surgery, LlcUltrasonic surgical instruments
US943967017 Mar 201413 Sep 2016Ethicon Endo-Surgery, Inc.Curved clamp arm for use with ultrasonic surgical instruments
US944583221 Jun 201320 Sep 2016Ethicon Endo-Surgery, LlcSurgical instruments
US948622911 May 20128 Nov 2016Broncus Medical Inc.Methods and devices for excision of tissue
US95044833 Jul 201229 Nov 2016Ethicon Endo-Surgery, LlcSurgical instruments
US950485520 Mar 201529 Nov 2016Ethicon Surgery, LLCDevices and techniques for cutting and coagulating tissue
US951085011 Nov 20136 Dic 2016Ethicon Endo-Surgery, LlcUltrasonic surgical instruments
US953312831 Oct 20123 Ene 2017Broncus Medical Inc.Devices for maintaining patency of surgically created channels in tissue
US961584427 Abr 201611 Abr 2017Med-Sonics CorporationSystems and methods for controlling delivery of ultrasonic energy to a bodily tissue
US962323728 Sep 201518 Abr 2017Ethicon Endo-Surgery, LlcSurgical generator for ultrasonic and electrosurgical devices
US962964313 Jul 201225 Abr 2017Flowcardia, Inc.Ultrasound catheter having improved distal end
US9636135 *10 Nov 20142 May 2017Ethicon Endo-Surgery, LlcUltrasonic surgical instruments
US964264412 Mar 20159 May 2017Ethicon Endo-Surgery, LlcSurgical instruments
US96491266 Ene 201516 May 2017Ethicon Endo-Surgery, LlcSeal arrangements for ultrasonically powered surgical instruments
US970033920 May 200911 Jul 2017Ethicon Endo-Surgery, Inc.Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments
US97003432 Nov 201511 Jul 2017Ethicon Endo-Surgery, LlcDevices and techniques for cutting and coagulating tissue
US970700412 Mar 201518 Jul 2017Ethicon LlcSurgical instruments
US970702720 May 201118 Jul 2017Ethicon Endo-Surgery, LlcMedical device
US97134817 Oct 201525 Jul 2017Med-Sonics CorporationApparatus and methods for transferring ultrasonic energy to a bodily tissue
US97135074 Ene 201625 Jul 2017Ethicon Endo-Surgery, LlcClosed feedback control for electrosurgical device
US972411815 Mar 20138 Ago 2017Ethicon Endo-Surgery, LlcTechniques for cutting and coagulating tissue for ultrasonic surgical instruments
US973732623 Oct 201522 Ago 2017Ethicon Endo-Surgery, LlcHaptic feedback devices for surgical robot
US97439479 Dic 201529 Ago 2017Ethicon Endo-Surgery, LlcEnd effector with a clamp arm assembly and blade
US9757536 *14 Sep 201212 Sep 2017Novartis AgSoft tip cannula
US97636842 Abr 201519 Sep 2017Med-Sonics CorporationDevices and methods for removing occlusions from a bodily cavity
US976416420 Dic 201319 Sep 2017Ethicon LlcUltrasonic surgical instruments
US979540518 Feb 201524 Oct 2017Ethicon LlcSurgical instrument
US979580813 Mar 201524 Oct 2017Ethicon LlcDevices and techniques for cutting and coagulating tissue
US980164828 Oct 201431 Oct 2017Ethicon LlcSurgical instruments
US20020026184 *18 Oct 200128 Feb 2002Witt David A.Curved clamp arm tissue pad attachment for use with ultrasonic surgical instruments
US20020082238 *1 Mar 200227 Jun 2002Pharmasonics, Inc.Methods, systems, and kits for intravascular nucleic acid delivery
US20020128647 *21 Feb 200212 Sep 2002Ed RoschakDevices for applying energy to tissue
US20020143355 *14 Ene 20023 Oct 2002Messerly Jeffrey D.Blades with functional balance asymmetries for use with ultrasonic surgical instruments
US20030009125 *27 Jun 20029 Ene 2003Henry NitaUltrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels
US20030040501 *9 Ago 200227 Feb 2003Pharmasonics, Inc.Methods, systems, and kits for intravascular nucleic acid delivery
US20030153833 *6 Mar 200314 Ago 2003Bennett Frederick J.Ultrasound catheter with utility lumen
US20030187368 *12 Jun 20012 Oct 2003Masataka SataMedical guide wire doubling as a catheter
US20030216681 *18 Feb 200320 Nov 2003John ZhangSheath for use with an ultrasound element
US20030236560 *7 Abr 200325 Dic 2003Eilaz BabaevUltrasonic method and device for wound treatment
US20040015122 *18 Feb 200322 Ene 2004John ZhangSheath for use with an ultrasound element
US20040019318 *7 Nov 200229 Ene 2004Wilson Richard R.Ultrasound assembly for use with a catheter
US20040039311 *26 Ago 200226 Feb 2004Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
US20040049148 *3 Dic 200211 Mar 2004Oscar RodriguezSmall vessel ultrasound catheter
US20040073155 *9 Jun 200315 Abr 2004Broncus Technologies, Inc.Methods and devices for maintaining patency of surgically created channels in tissue
US20040097996 *19 Sep 200320 May 2004Omnisonics Medical Technologies, Inc.Apparatus and method of removing occlusions using an ultrasonic medical device operating in a transverse mode
US20040138570 *14 Ene 200315 Jul 2004Flowcardia, Inc., A Delaware CorporationUltrasound catheter and methods for making and using same
US20040167507 *26 Feb 200326 Ago 2004Flowcardia, Inc.Ultrasound catheter apparatus
US20040186384 *1 Abr 200423 Sep 2004Eilaz BabaevUltrasonic method and device for wound treatment
US20040199228 *5 Ene 20047 Oct 2004Wilson Richard R.Ultrasonic catheter with axial energy field
US20040204670 *8 Abr 200314 Oct 2004Flowcardia, Inc., A Delaware CorporationUltrasound catheter devices and methods
US20040229830 *19 Feb 200418 Nov 2004Katsuro TachibanaDelivery of therapeutic compositions using ultrasound
US20040230117 *16 Abr 200418 Nov 2004Tosaya Carol A.Non-contact damage-free ultrasonic cleaning of implanted or natural structures having moving parts and located in a living body
US20050010112 *12 Dic 200313 Ene 2005Bennett Frederick J.Ultrasound assembly with increased efficacy
US20050043752 *19 Jul 200424 Feb 2005Broncus Technologies, Inc.Methods and devices for maintaining patency of surgically created channels in a body organ
US20050049615 *15 Oct 20043 Mar 2005Broncus Technologies, Inc.Methods for treating chronic obstructive pulmonary disease
US20050060042 *19 Jul 200417 Mar 2005Broncus Technologies, Inc.Methods and devices for maintaining surgically created channels in a body organ
US20050060044 *19 Jul 200417 Mar 2005Ed RoschakMethods and devices for maintaining patency of surgically created channels in a body organ
US20050096529 *1 Nov 20045 May 2005Broncus Technologies, Inc.Methods for treating chronic obstructive pulmonary disease
US20050107783 *17 Dic 200419 May 2005Broncus Technologies, Inc.Devices for applying energy to tissue
US20050113688 *24 Nov 200326 May 2005Flowcardia, Inc.,Steerable ultrasound catheter
US20050137611 *19 Jul 200423 Jun 2005Broncus Technologies, Inc.Methods and devices for maintaining surgically created channels in a body organ
US20050137715 *1 Dic 200423 Jun 2005Broncus Technologies, Inc.Methods and devices for maintaining patency of surgically created channels in a body organ
US20050183739 *24 Feb 200425 Ago 2005Mcdermott Wayne T.Transmission of ultrasonic energy into pressurized fluids
US20050197619 *28 Ene 20058 Sep 2005Rule Peter R.Ultrasound enhanced central venous catheter
US20050209578 *28 Ene 200522 Sep 2005Christian Evans Edward AUltrasonic catheter with segmented fluid delivery
US20050245951 *11 Jul 20053 Nov 2005Flowcardia, Inc., A Delaware CorporationUltrasound catheter apparatus
US20060020262 *23 Sep 200526 Ene 2006Witt David ACurved clamp arm tissue pad attachment for use with ultrasonic surgical instruments
US20060025716 *18 Ago 20052 Feb 2006Eilaz BabaevNozzle for ultrasound wound treatment
US20060047239 *26 Ago 20042 Mar 2006Flowcardia, Inc.Ultrasound catheter devices and methods
US20060084963 *17 Ago 200520 Abr 2006Messerly Jeffrey DBlades with functional balance asymmetries for use with ultrasonic surgical instruments
US20060122507 *20 Oct 20058 Jun 2006Rule Peter RUltrasound enhanced central venous catheter
US20060142672 *16 Feb 200629 Jun 2006Broncus Technologies, Inc.Devices for applying energy to tissue
US20060161098 *20 Ene 200520 Jul 2006Flowcardia, Inc.Vibrational catheter devices and methods for making same
US20060206039 *4 May 200614 Sep 2006Wilson Richard RUltrasound catheter with embedded conductors
US20060253050 *15 Jun 20069 Nov 2006Olympus CorporationUltrasonic treatment apparatus, and probe, treatment portion and large-diameter portion for ultrasonic treatment apparatus
US20060276807 *16 Feb 20067 Dic 2006Broncus Technologies, Inc.Methods for treating chronic obstructive pulmonary disease
US20060280772 *1 Jun 200614 Dic 2006Broncus Technologies, Inc.Methods and devices for maintaining surgically created channels in a body organ
US20060280773 *1 Jun 200614 Dic 2006Broncus Technologies, Inc.Methods and devices for maintaining patency of surgically created channels in a body organ
US20070021690 *23 Ago 200625 Ene 2007Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
US20070021691 *24 Ago 200625 Ene 2007Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
US20070038158 *25 Jul 200615 Feb 2007Flowcardia, Inc.Ultrasound catheter devices and methods
US20070112268 *3 May 200617 May 2007John ZhangSheath for use with an ultrasound element
US20070149917 *15 Feb 200728 Jun 2007Bennett Frederick JUltrasound catheter
US20070161951 *13 Mar 200712 Jul 2007Ekos CorporationTreatment of vascular occlusions using elevated temperatures
US20070239027 *5 Abr 200611 Oct 2007Henry NitaTherapeutic ultrasound system
US20080051660 *3 Ago 200728 Feb 2008The University Of Houston SystemMethods and apparatuses for medical imaging
US20080097251 *15 Jun 200624 Abr 2008Eilaz BabaevMethod and apparatus for treating vascular obstructions
US20080103417 *25 Oct 20071 May 2008Azita SoltaniCatheter with multiple ultrasound radiating members
US20080108902 *21 Dic 20078 May 2008Henry NitaUltrasound catheter having protective feature against breakage
US20080167602 *28 Ene 200810 Jul 2008Flowcardia, Inc.Steerable ultrasound catheter
US20080171965 *8 Ene 200817 Jul 2008Ekos CorporationPower parameters for ultrasonic catheter
US20080172067 *25 Feb 200817 Jul 2008Flowcardia, Inc.Steerable ultrasound catheter
US20080172076 *1 Nov 200617 Jul 2008Alcon, Inc.Ultrasound apparatus and method of use
US20080202550 *28 Abr 200828 Ago 2008Air Products And Chemicals, Inc.Transmission of Ultrasonic Energy into Pressurized Fluids
US20080228111 *22 May 200818 Sep 2008Flowcardia, Inc.Therapeutic ultrasound system
US20080287804 *18 Jul 200820 Nov 2008Henry NitaUltrasound catheter having improved distal end
US20090018472 *9 Jul 200815 Ene 2009Azita SoltaniPower parameters for ultrasonic catheter
US20090024076 *7 Jul 200822 Ene 2009Celleration, Inc.Nozzle for ultrasound wound treatment
US20090043248 *17 Jul 200812 Feb 2009Celleration, Inc.Removable multi-channel applicator nozzle
US20090177123 *23 Dic 20089 Jul 2009Celleration, Inc.Methods for treating inflammatory disorders
US20100022919 *22 Jul 200928 Ene 2010Celleration, Inc.Methods of Skin Grafting Using Ultrasound
US20100022920 *7 Ago 200928 Ene 2010Flowcardia, Inc.Ultrasound catheter and methods for making and using same
US20100023036 *7 Ago 200928 Ene 2010Flowcardia, Inc.Ultrasound catheter and methods for making and using same
US20100049209 *1 Oct 200925 Feb 2010Flowcardia, Inc.Ultrasound catheter apparatus
US20100057097 *3 Sep 20084 Mar 2010Jan MaMicro-emulsifier for arterial thrombus removal
US20100317973 *12 Jun 200916 Dic 2010Henry NitaDevice and method for vascular re-entry
US20110004105 *2 Jul 20106 Ene 2011Ekos CorporationPower parameters for ultrasonic catheter
US20110060253 *6 Jul 201010 Mar 2011Ekos CorporationUltrasonic catheter with axial energy field
US20110112466 *11 Nov 200912 May 2011Ramon Carsola DimalantaExtended Point Phacoemulsification Tip
US20110125164 *1 Feb 201126 May 2011Flowcardia, Inc.Ultrasound catheter devices and methods
US20110184446 *7 Abr 201128 Jul 2011Witt David ACurved clamp arm for use with ultrasonic surgical instruments
US20110201974 *17 Feb 201118 Ago 2011Ekos CorporationTreatment of vascular occlusions using ultrasonic energy and microbubbles
US20110230795 *28 Mar 201122 Sep 2011Eilaz BabaevUltrasonic method and device for wound treatment
US20120022393 *19 Jul 201126 Ene 2012Christian PrucknerMedical treatment device
US20130131705 *9 Nov 201223 May 2013Olympus Medical Systems Corp.Ultrasonic probe
US20150005775 *28 Jun 20131 Ene 2015Misonix IncorporatedUltrasonic cutting blade with cooling liquid conduction
US20150066067 *10 Nov 20145 Mar 2015Ethicon Endo-Surgery, Inc.Ultrasonic surgical instruments
CN100584285C31 May 200527 Ene 2010奥林巴斯株式会社;奥林巴斯医疗株式会社Ultrasonic treatment implement, and probe for ultrasonic treatment implement
CN103327920A *27 Feb 201225 Sep 2013奥林巴斯医疗株式会社超声波探头
CN104736076A *9 Oct 201324 Jun 2015伊西康内外科公司Flexible harmonic waveguides/blades for surgical instruments
CN104736076B *9 Oct 201329 Sep 2017伊西康内外科公司用于外科器械的柔性谐波波导/刀片
DE2626373A1 *11 Jun 197613 Ene 1977Fibra SonicsMedizinisches geraet fuer chirurgische eingriffe und heilbehandlungseinrichtung mit ultraschallenergie
DE3247124A1 *20 Dic 198220 Oct 1983Go G Med Inst Im S M Kirova GoVorrichtung zur zerstoerung und aspiration von augengewebe
EP0229003A1 *4 Nov 198615 Jul 1987Swedemed ABUltrasonic aspirator
EP0238667A1 *15 Jul 198630 Sep 1987Sumitomo Bakelite Company LimitedUltrasonic instrument for surgical operations
EP0238667A4 *15 Jul 19867 Nov 1988Sumitomo Bakelite CoUltrasonic instrument for surgical operations.
EP0316796A2 *11 Nov 198824 May 1989DonMichael, Anthony T.Intravascular ultrasonic catheter probe for treating intravascular blockage
EP0316796A3 *11 Nov 198827 Sep 1989Anthony T. DonmichaelIntravascular ultrasonic catheter probe and method for treating intravascular blockage
EP0401158A1 *11 May 19905 Dic 1990Schneider (Europe) AgCatheter apparatus with a guide wire and method for the production of such a guide wire
EP0514810A1 *18 May 199225 Nov 1992Rosa Antonio LaUltrasonic dissector and detacher for atherosclerotic plaques
EP0627897A1 *26 Ene 199314 Dic 1994Angiosonics Inc.Ultrasonic transmission apparatus
EP0627897A4 *26 Ene 199310 May 1995Angiosonics IncUltrasonic transmission apparatus.
EP0784451A1 *6 Oct 199523 Jul 1997Misonix Inc.Ultrasonic lipectomy probe and method for manufacture
EP0784451A4 *6 Oct 199527 Ene 1999Misonix IncUltrasonic lipectomy probe and method for manufacture
EP0820727A24 May 199328 Ene 1998Baxter International Inc.Ultrasonic angioplasty catheter device
EP0820728A24 May 199328 Ene 1998Baxter International Inc.Ultrasonic angioplasty catheter device
EP0891744A1 *26 Ene 199320 Ene 1999Angiosonics Inc.Ultrasonic transmission apparatus
EP1022985A1 *29 Sep 19982 Ago 2000Angiosonics Inc.Lysis method and apparatus
EP1022985A4 *29 Sep 199817 Nov 2004Angiosonics IncLysis method and apparatus
EP1255495A1 *2 Feb 200113 Nov 2002Sound Surgical Technologies LLCUltrasonic cutting and coagulation knife using transverse vibrations
EP1255495A4 *2 Feb 200115 Feb 2006Sound Surgical Tech LlcUltrasonic cutting and coagulation knife using transverse vibrations
EP1570918A2 *17 Feb 20057 Sep 2005Air Products And Chemicals, Inc.Transmission of ultrasonic energy into pressurized fluids
EP1570918A3 *17 Feb 200527 Dic 2006Air Products And Chemicals, Inc.Transmission of ultrasonic energy into pressurized fluids
EP2417945A219 Mar 200415 Feb 2012Flowcardia Inc.Improved ultrasound catheter devices and methods
EP2471474A113 Feb 20044 Jul 2012Flowcardia Inc.Ultrasound catheter apparatus
EP2609878A119 Mar 20043 Jul 2013FlowCardia, Inc.Improved ultrasound catheter devices and methods
EP2636382A1 *27 Feb 201211 Sep 2013Olympus Medical Systems Corp.Ultrasonic probe
EP2636382A4 *27 Feb 201226 Mar 2014Olympus Medical Systems CorpUltrasonic probe
WO1991012773A1 *6 Feb 19915 Sep 1991Devices For Vascular Intervention, Inc.System and method for catheter construction
WO1992010140A1 *27 Nov 199125 Jun 1992Coraje, Inc.Miniature ultrasonic transducer for plaque ablation and clot dissolution
WO1998030155A1 *7 Ene 199816 Jul 1998Storz Endoskop GmbhHandpiece for use with a multifunctional operating endoscopic instrument
WO2001024714A1 *8 Sep 200012 Abr 2001Ethicon Endo-Surgery, Inc.Multifunctional curved blade for use with an ultrasonic surgical instrument
WO2004018019A226 Ago 20034 Mar 2004Flowcardia, Inc.Ultrasound catheter for disrupting blood vessel obstructions
WO2004093736A219 Mar 20044 Nov 2004Flowcardia, Inc.Improved ultrasound catheter devices and methods
WO2005053769A225 Oct 200416 Jun 2005Flowcardia, Inc.Steerable ultrasound catheter
WO2006030563A1 *31 May 200523 Mar 2006Olympus CorporationUltrasonic treatment implement, and probe, treatment section, and large-diameter section for ultrasonic treatment implement
WO2014062646A3 *15 Oct 201317 Jul 2014Med-Sonics CorporationApparatus and methods for transferring ultrasonic energy to a bodily tissue
WO2014066044A1 *9 Oct 20131 May 2014Ethicon Endo-Surgery, Inc.Flexible harmonic waveguides/blades for surgical instruments
WO2015074038A1 *18 Nov 201421 May 2015Jeremy StigallMethods and devices for thrombus dispersal with cooling element
Clasificaciones
Clasificación de EE.UU.606/159, 604/22, 601/4, 606/169
Clasificación internacionalA61B19/00, A61B18/00, A61B17/32, B06B3/00, B23Q1/00, A61B17/22, A61F7/00, A61M3/02, A61B17/00, B23Q5/027, A61M25/00
Clasificación cooperativaA61B17/320068, A61B2017/32008, A61B2018/00011, A61F2007/0063, B23Q5/027, A61B2017/320072, A61B2017/22018, A61B2017/320096, A61M25/0069, B06B3/00, B23Q1/0027, A61M3/0279, A61B2017/00473, A61B17/22012
Clasificación europeaA61M25/00T10A, A61B17/22B2, B23Q1/00B2B, A61B17/32U, B23Q5/027, B06B3/00