US3466249A - Blood serum reference standard for multi-automated analytical procedures - Google Patents
Blood serum reference standard for multi-automated analytical procedures Download PDFInfo
- Publication number
- US3466249A US3466249A US615339A US3466249DA US3466249A US 3466249 A US3466249 A US 3466249A US 615339 A US615339 A US 615339A US 3466249D A US3466249D A US 3466249DA US 3466249 A US3466249 A US 3466249A
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- United States
- Prior art keywords
- serum
- blood serum
- reference standard
- carbon dioxide
- blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/05—Reference solutions for assays of biological material containing blood cells or plasma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/70—Blood gas control solutios containing dissolved oxygen, bicarbonate and the like
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/80—Multi-analyte reference solutions containing cholesterol, glucose and the like
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/102499—Blood gas standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
United States Patent 3,466,249 BLOOD SERUM REFERENCE STANDARD FOR MULTI-AUTOMATED ANALYTICAL PROCEDURES Roy A. Anderson, North Hollywood, Calif., assignor to Baxter Laboratories, Inc., Morton Grove, 11]., a corporation of Delaware No Drawing. Filed Feb. 13, 1967, Ser. No. 615,339 Int. Cl. C09k 3/00 U.S. Cl. 252-408 4 Claims ABSTRACT OF THE DISCLOSURE A stable blood serum reference standard having a standard carbon dioxide content for use in multi-automated analytical procedures in which a freeze-dried blood serum component of the reference standard is reconstituted with an aqueous ammonium bicarbonate component of the reference standard.
This invention relates to a laboratory standard material and, more particularly, to a stable blood serum reference standard and to a method of preparation and use thereof.
The rapid quantitation or estimation of various blood serum components has become a valuble adjunct in the clinical diagnosis of disease. In recent years a number of elaborate electronic devices have been developed for making rapid and precise analytical determinations on blood serum and other biochemical samples. An automatic analyzer known as the Robot Chemist made by Warner-Chilcott Laboratories and various instruments known by the name AutoAnalyzer made by Technicon Instruments are examples of such electronic devices capable of making rapid and precise analytical determinations. Some of the various biochemical determinations which the above and similar electronic devices are presently adaptable to are, for example, albumin, acid phosphatase, alkaline, phosphatase, bilirubin, calcium, carbon dioxide, chloride, cholesterol, glucose, hemoglobin, LDH, potassium, sodium, total protein, transaminase, urea nitrogen and uric acid. One particular instrument available on the market (known as the 12 Channel AutoAnalyzer) is capable of simultaneously making twelve different analyses on a single sample.
In the performance of the analytical tests made by the above and similar electronic devices on blood serum and other biological samples, it is necessary to use laboratory standard materials or so-called reference standards for purposes of calibration and control of the instrument. Accurate results in the use of these instruments, particularly in the case of multi-automated procedures, are dependent upon rigid and constant standardization of the biochemical determinations.
Since blood is a complex material which contains numerous substances, multi-automated procedures lend themselves ideally to the analysis of blood. Of the many functions of blood, an important one is to carry raw materials to the tissues and remove the waste products therefrom. One of the most essential of these raw materials is oxygen, and an important waste product is carbon dioxide which the hemoglobin of the red cells carries away from the tissues to which it has delivered oxygen. Also, the carbon dioxide in normal blood is maintained in equilibrium with H CO and HCO to comprise an important buffering system for controlling the pH of the blood. Consequently, determination of the carbon dioxide content of the blood serum is of great importance in many clinical procedures. A multi-automated procedure which includes an arcuate determination of the carbon ice dioxide content of blood would, therefore, be very useful in the clinical laboratory.
Accordingly, it is an object of this invention to provide a stable blood serum reference standard which includes a standard carbon dioxide content.
It is another object of this invention to provide a stable blood serum reference standard which includes a standand carbon dioxide content and which can be used for calibration and control of multi-automated analytical procedures.
As used herein, the term carbon dioxide content refers to the total equivalent amount of carbon dioxide in the form of CO H CO and HCO As used herein, the term multi-automated procedure refers to an automated chemical analytical procedure in which two or more analyses are made simultaneously on a single sample.
In brief, the blood serum reference standard of the present invention comprises a freeze-dried serum prepared from human blood and a separate aqueous solution of ammonium bicarbonate for use in reconstitution of the freeze-dried serum.
The freeze-dried serum used in the practice of this invention is stable for at least two years at temperatures ranging from about 2 to about 10 C. In the method of this invention, the freeze-dried serum is reconstituted with sufficient aqueous ammonium bicarbonate solution (a) to provide from about 12 to about 35 meq./liter of carbon dioxide content in the reconstituted serum or (b) to increase the carbon dioxide content of the reconstituted serum to any predetermined level, depending upon the particular analytical procedure concerned. This reconstituted serum is stable for at least three days at temperatures ranging from about 2 to about 10 C., and is directly used for the calibration and control of the instruments used in the multi-automated analytical procedures.
The freeze-dried serum used in the practice of the present invention can be prepared by any conventional method of freeze-drying whereby the serum is dried from the frozen state under a high vacuum and ice or other frozen solvent rapidly sublimes to yield a porous solid.
The use of the separate aqueous solution of the ammonium bicarbonate for reconstitution of the freeze-dried serum has been found necessary according to the present invention to provide a stable blood serum reference standard. It has been found that in the freeze-drying of the blood serum, a substantial amount of the carbon dioxide content of the serum is lost in the form of gaseous CO And in order to preserve enzymes in the serum, acid is added to provide the optimum pH at which the enzymes remain active. This acidification causes even further losses in the carbon dioxide content of the serum.
The ammonium bicarbonate reconstituting solution is uniquely suited as a component of the blood serum reference standard of this invention in that:
(1) It is stable in solution when hermetically sealed and sterilized.
(2) It has a composition that does not cause interference with measurement of any of the constituents of blood ordinarily tested in multi-automated analytical procedures.
(3) It has a composition that does not undesirably contribute constituents which would throw otf any of the ordinary target values for the blood serum reference standard, i.e., values substantially the same as in normal human blood serum or values ideally suited to multi-automated analytical procedures.
(4) It has a pH in such a range that the final pH (e.g., pH 7510.5) of the reconstituted serum is within an acceptable range for the test systems as well as for stability of the components, particularly the enzymes.
(5) It contributes to the carbonate-bicarbonate system when added to the serum to produce a carbon dioxide content that is suitable for standardizing and controlling the test.
(6) It has no color and can be filtered to produce a water-clear solution.
The following example will further illustrate the present invention although the invention is not limited to this specific example which is provided by Way of illustration and not limitation.
EXAMPLE A solution of ammonium bicarbonate was prepared by dissolving 426.6 g. of ammonium bicarbonate (A.R. grade) in 180 liters of distilled water. The solution was clarified by passage through Millipore membranes (1.2 and 0.45 micron), filled into 50 ml. bottles, stoppered, hermetically sealed and then sterilized by autoclaving at 255 F. for 30 minutes.
Freeze-dried human blood serum representing an original volume of 50 m1. of liquid serum was reconstituted to its original volume by the addition of 50 ml. of the above ammonium bicarbonate solution. The mixture was slightly agitated by rotation of the bottle to completely wet the serum with the aqueous solution and then placed in a refrigerator until the serum was completely dissolved. A sample of the reconstituted serum had the following analysis:
Constituent: Mean value Albumin, g./100 ml. 3.9 Alkaline phosphatase, units 18 1 Bilirubin, mg./l00 ml. 1.8 Calcium, mg./ 100 ml. 9.0 Chloride, meq./l. 101 Carbon dioxide content, meq./l. 25 1 Glucose, mg./100 ml. 230 Potassium, rneq./l. 5.0 Sodium, meq./l. 140 Total protein, g./100 ml. 6.8 1 Transaminase (GOT), units 100 Urea nitrogen, mg./l00 ml. 68
These values are in an elevated range. The liquid serum was preadjusted (prior to freeze-drying) by the addition of pure compounds and other substances to give values in certain ideal ranges for standardizing nlulti-channel automated instruments such as the "12 Channel AutoAnalyzer.
The above reconstituted serum can be used for the standardization and control of multi-automated analytical procedures for blood serum such as with the 12 Channel AutoAnalyzer made by Technicon Instruments.
As will be readily apparent to those skilled in the art,
other examples of the herein-defined invention can be devised after reading the foregoing specification and the claims appended hereto by various modifications, variations and adaptations without departing from the spirit and scope of the invention. All such modifications, variations and adaptations are included within the scope of the invention as defined in the appended claims.
What is claimed is:
1. A blood serum reference standard comprising a first container of freeze-dried blood serum and a second container of aqueous ammonium bicarbonate, the concentration of said aqueous ammonium bicarbonate being such that when the serum is reconstituted with the aqueous ammoniurn bicarbonate the carbon dioxide content of the reconstituted serum is from about 12 to about meq./ liter.
2. The method of providing an accurate blood serum reference standard including a standard carbon dioxide content for use in multi-automated analytical procedures comprising reconstituting freeze-dried blood serum with an aqueous solution of ammonium bicarbonate such that the carbon dioxide content of the reconstituted serum is increased to a predetermined level.
3. The method of providing an accurate blood serum 0 reference standard including a standard carbon dioxide UNITED STATES PATENTS 2,225,744 12/1940 Flosdorf 252-408 2,770,602 11/1956 Weichselbaum 252-408 3,000,836 9/1961 Ginsburg 252408 3,147,081 9/1964 Stevenson et a1.
MORRIS O. WOLK, Primary Examiner R. E. SERWIN, Assistant Examiner US. Cl. X.R.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61533967A | 1967-02-13 | 1967-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3466249A true US3466249A (en) | 1969-09-09 |
Family
ID=24464936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US615339A Expired - Lifetime US3466249A (en) | 1967-02-13 | 1967-02-13 | Blood serum reference standard for multi-automated analytical procedures |
Country Status (4)
Country | Link |
---|---|
US (1) | US3466249A (en) |
BE (1) | BE708522A (en) |
DE (1) | DE1698180C3 (en) |
GB (1) | GB1159629A (en) |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3859049A (en) * | 1973-09-14 | 1975-01-07 | Arnold G Ware | Blood reference standard and process for blood gas test |
US3897363A (en) * | 1973-08-10 | 1975-07-29 | Baxter Laboratories Inc | Blood control standard |
US3973913A (en) * | 1976-01-29 | 1976-08-10 | Louderback Allan Lee | Blood control standard |
US4001142A (en) * | 1975-07-25 | 1977-01-04 | Warner-Lambert Company | Blood gas control |
US4056484A (en) * | 1974-12-31 | 1977-11-01 | Behringwerke Aktiengesellschaft | Stable blood plasma, process for preparing it and its use as comparative plasma in coagulation tests |
DE2723070A1 (en) * | 1976-05-24 | 1977-12-15 | Dorwart Jun | REFERENCE PREPARATION FOR DETERMINING ANION CONCENTRATION IN CHEMICAL ANALYZES |
US4121905A (en) * | 1977-08-22 | 1978-10-24 | Jonas Maurukas | Process for preparing biological compositions for use as reference controls in diagnostic analyses |
US4141856A (en) * | 1976-05-24 | 1979-02-27 | Dorwart Jr William V | Reference material for establishing anion concentrations in analytical chemistry tests |
US4158544A (en) * | 1978-07-17 | 1979-06-19 | Beckman Instruments, Inc. | Process for preparing a biological composition for use as a reference control in diagnostic analysis |
US4163734A (en) * | 1975-05-30 | 1979-08-07 | Radiometer A/S | Reference liquid for blood gas equipment |
US4219440A (en) * | 1979-06-06 | 1980-08-26 | Coulter Electronics, Inc. | Multiple analysis hematology reference control reagent and method of making the same |
US4287087A (en) * | 1977-02-25 | 1981-09-01 | Research Triangle Institute | Fixed-dried blood platelets |
US4323478A (en) * | 1977-01-18 | 1982-04-06 | Baxter Travenol Laboratories, Inc. | Novel particulate compositions |
US4324685A (en) * | 1978-07-17 | 1982-04-13 | Beckman Instruments, Inc. | Blood serum reference standard |
US4325832A (en) * | 1979-03-05 | 1982-04-20 | Beckman Instruments, Inc. | Enzyme reference composition |
US4351743A (en) * | 1976-04-07 | 1982-09-28 | Yoshikazu Hashimoto | Dilute standard gases prepared by utilizing buffered solution, method for preparation thereof and apparatus therefor |
WO1983003902A1 (en) * | 1982-05-03 | 1983-11-10 | American Hospital Supply Corporation | Blood gas control |
US4485174A (en) * | 1982-09-29 | 1984-11-27 | Instrumentation Laboratory Inc. | Hemoglobin-based blood gas control |
EP0358250A2 (en) * | 1988-08-10 | 1990-03-14 | INSTRUMENTATION LABORATORY S.p.A. | Method and apparatus for liquid phase calibration of oxigen and carbon dioxide partial pressure |
US4960708A (en) * | 1988-10-13 | 1990-10-02 | Baxter International Inc. | Pressurized packaged reference liquid for blood gas analysis |
US5296377A (en) * | 1992-12-15 | 1994-03-22 | Boehringer Mannheim Corporation | Control reagent containing a hydroxylamine or an antioxidant |
US5308767A (en) * | 1986-10-31 | 1994-05-03 | Fuji Photo Film Co., Ltd. | Method for control or calibration in a chemical analytical determination |
US5547874A (en) * | 1986-10-31 | 1996-08-20 | Fuji Photo Film Co., Ltd. | Method for control or calibration in a chemical analytical determination |
US6268481B1 (en) | 1997-05-29 | 2001-07-31 | Medical Analysis Systems, Inc. | Covalently coupled troponin complexes |
CN101930009A (en) * | 2009-11-19 | 2010-12-29 | 首都医科大学附属北京朝阳医院 | Serum calcium standard substance |
US20110201121A1 (en) * | 2005-08-24 | 2011-08-18 | Berggren Oy Ab | Method of testing a liquid sample, a test unit, and an automatized system of a plurality of test units |
US9863699B2 (en) | 2014-06-09 | 2018-01-09 | Terumo Bct, Inc. | Lyophilization |
US10793327B2 (en) | 2017-10-09 | 2020-10-06 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
US11604026B2 (en) | 2019-03-14 | 2023-03-14 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4260579A (en) * | 1979-05-10 | 1981-04-07 | Miles Laboratories, Inc. | Device and method for simulating bilirubin in urine |
US5061631A (en) * | 1988-10-14 | 1991-10-29 | Fisher Scientific Company | Method, apparatus and solution for calibration of partial pressure value |
DE4235311C2 (en) * | 1992-10-20 | 1997-10-02 | Dieter Pfaff | Bilirubin calibration agent for photometric determination of bilirubin |
CN106908291A (en) * | 2017-02-17 | 2017-06-30 | 嘉兴博泰生物科技发展有限公司 | A kind of preparation method of serum glucose standard substance |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2225744A (en) * | 1938-08-25 | 1940-12-24 | Commw Edison Co | Process of removing and recovering sulphur dioxide |
US2770602A (en) * | 1951-06-25 | 1956-11-13 | Aloe Company As | Method of preparing protein standardized reagents |
US3000836A (en) * | 1958-09-02 | 1961-09-19 | Ginsburg Ben | Stabilized whole blood standard and method of making the same |
US3147081A (en) * | 1961-02-27 | 1964-09-01 | Beckman Instruments Inc | Technique in blood testing |
-
1967
- 1967-02-13 US US615339A patent/US3466249A/en not_active Expired - Lifetime
- 1967-12-12 GB GB56325/67A patent/GB1159629A/en not_active Expired
- 1967-12-27 BE BE708522D patent/BE708522A/xx unknown
-
1968
- 1968-01-09 DE DE1698180A patent/DE1698180C3/en not_active Expired
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2225744A (en) * | 1938-08-25 | 1940-12-24 | Commw Edison Co | Process of removing and recovering sulphur dioxide |
US2770602A (en) * | 1951-06-25 | 1956-11-13 | Aloe Company As | Method of preparing protein standardized reagents |
US3000836A (en) * | 1958-09-02 | 1961-09-19 | Ginsburg Ben | Stabilized whole blood standard and method of making the same |
US3147081A (en) * | 1961-02-27 | 1964-09-01 | Beckman Instruments Inc | Technique in blood testing |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3897363A (en) * | 1973-08-10 | 1975-07-29 | Baxter Laboratories Inc | Blood control standard |
US3859049A (en) * | 1973-09-14 | 1975-01-07 | Arnold G Ware | Blood reference standard and process for blood gas test |
US4056484A (en) * | 1974-12-31 | 1977-11-01 | Behringwerke Aktiengesellschaft | Stable blood plasma, process for preparing it and its use as comparative plasma in coagulation tests |
US4163734A (en) * | 1975-05-30 | 1979-08-07 | Radiometer A/S | Reference liquid for blood gas equipment |
US4001142A (en) * | 1975-07-25 | 1977-01-04 | Warner-Lambert Company | Blood gas control |
US3973913A (en) * | 1976-01-29 | 1976-08-10 | Louderback Allan Lee | Blood control standard |
US4351743A (en) * | 1976-04-07 | 1982-09-28 | Yoshikazu Hashimoto | Dilute standard gases prepared by utilizing buffered solution, method for preparation thereof and apparatus therefor |
FR2353060A1 (en) * | 1976-05-24 | 1977-12-23 | Dorwart Jr William | BLOOD SERUM STANDARD AND PREPARATION METHOD |
US4141856A (en) * | 1976-05-24 | 1979-02-27 | Dorwart Jr William V | Reference material for establishing anion concentrations in analytical chemistry tests |
DE2723070A1 (en) * | 1976-05-24 | 1977-12-15 | Dorwart Jun | REFERENCE PREPARATION FOR DETERMINING ANION CONCENTRATION IN CHEMICAL ANALYZES |
US4323478A (en) * | 1977-01-18 | 1982-04-06 | Baxter Travenol Laboratories, Inc. | Novel particulate compositions |
US4287087A (en) * | 1977-02-25 | 1981-09-01 | Research Triangle Institute | Fixed-dried blood platelets |
WO1979000106A1 (en) * | 1977-08-22 | 1979-03-08 | J Maurukas | Process for preparing biological compositions for use as a reference control in diagnostic analysis |
US4121905A (en) * | 1977-08-22 | 1978-10-24 | Jonas Maurukas | Process for preparing biological compositions for use as reference controls in diagnostic analyses |
DE2856988C1 (en) * | 1977-08-22 | 1984-01-26 | Jonas Elyria Ohio Maurukas | Process for the preparation of biological compositions for use as reference control samples in diagnostic analysis |
US4158544A (en) * | 1978-07-17 | 1979-06-19 | Beckman Instruments, Inc. | Process for preparing a biological composition for use as a reference control in diagnostic analysis |
US4324685A (en) * | 1978-07-17 | 1982-04-13 | Beckman Instruments, Inc. | Blood serum reference standard |
US4325832A (en) * | 1979-03-05 | 1982-04-20 | Beckman Instruments, Inc. | Enzyme reference composition |
US4219440A (en) * | 1979-06-06 | 1980-08-26 | Coulter Electronics, Inc. | Multiple analysis hematology reference control reagent and method of making the same |
WO1983003902A1 (en) * | 1982-05-03 | 1983-11-10 | American Hospital Supply Corporation | Blood gas control |
US4458021A (en) * | 1982-05-03 | 1984-07-03 | American Hospital Supply Corporation | Blood gas control |
US4485174A (en) * | 1982-09-29 | 1984-11-27 | Instrumentation Laboratory Inc. | Hemoglobin-based blood gas control |
US5308767A (en) * | 1986-10-31 | 1994-05-03 | Fuji Photo Film Co., Ltd. | Method for control or calibration in a chemical analytical determination |
US5547874A (en) * | 1986-10-31 | 1996-08-20 | Fuji Photo Film Co., Ltd. | Method for control or calibration in a chemical analytical determination |
EP0358250A2 (en) * | 1988-08-10 | 1990-03-14 | INSTRUMENTATION LABORATORY S.p.A. | Method and apparatus for liquid phase calibration of oxigen and carbon dioxide partial pressure |
US5204266A (en) * | 1988-08-10 | 1993-04-20 | Instrumentation Laboratory Spa | Method and apparatus for liquid phase calibration of oxygen and carbon dioxide partial pressure |
EP0358250A3 (en) * | 1988-08-10 | 1990-09-12 | INSTRUMENTATION LABORATORY S.p.A. | Method and apparatus for liquid phase calibration of oxigen and carbon dioxide partial pressure |
US4960708A (en) * | 1988-10-13 | 1990-10-02 | Baxter International Inc. | Pressurized packaged reference liquid for blood gas analysis |
US5296377A (en) * | 1992-12-15 | 1994-03-22 | Boehringer Mannheim Corporation | Control reagent containing a hydroxylamine or an antioxidant |
US6268481B1 (en) | 1997-05-29 | 2001-07-31 | Medical Analysis Systems, Inc. | Covalently coupled troponin complexes |
US20110201121A1 (en) * | 2005-08-24 | 2011-08-18 | Berggren Oy Ab | Method of testing a liquid sample, a test unit, and an automatized system of a plurality of test units |
CN101930009B (en) * | 2009-11-19 | 2013-09-11 | 首都医科大学附属北京朝阳医院 | Serum calcium standard substance |
CN101930009A (en) * | 2009-11-19 | 2010-12-29 | 首都医科大学附属北京朝阳医院 | Serum calcium standard substance |
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US11634257B2 (en) | 2017-10-09 | 2023-04-25 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
US11604026B2 (en) | 2019-03-14 | 2023-03-14 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
US11609042B2 (en) | 2019-03-14 | 2023-03-21 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
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US11740019B2 (en) | 2019-03-14 | 2023-08-29 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
US11747082B2 (en) | 2019-03-14 | 2023-09-05 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
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Also Published As
Publication number | Publication date |
---|---|
DE1698180A1 (en) | 1972-01-05 |
BE708522A (en) | 1968-05-02 |
DE1698180C3 (en) | 1979-01-25 |
DE1698180B2 (en) | 1976-11-25 |
GB1159629A (en) | 1969-07-30 |
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