|Número de publicación||US3590808 A|
|Tipo de publicación||Concesión|
|Fecha de publicación||6 Jul 1971|
|Fecha de presentación||4 Sep 1968|
|Fecha de prioridad||4 Sep 1968|
|Número de publicación||US 3590808 A, US 3590808A, US-A-3590808, US3590808 A, US3590808A|
|Inventores||Wolf F Muller|
|Cesionario original||Us Catheter & Instr Corp|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (8), Citada por (96), Clasificaciones (13)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
United States Patent W011 F. Muller Southampton, N.Y.  AppLNo. 757,366
 Inventor  Filed Sept. 4, 1968  Patented July 6, 1971  Assignee United States Catheter & Instrument Corporation Glens Falls, N.Y.
 BIOPSY TOOL 9 Claims, 12 Drawing Figs.
 US. Cl 128/2 B, 128/305  lnt.C1 ..A61b 10/00 (50] Field of Search 128/2, 2 B, 349, 356, 305, 309, 303-314  References Cited UNITED STATES PATENTS 2,212,133 8/1940 Stadle 128/305 2,684,069 7/1954 Donaldson et al 128/303 2,708,437 5/1955 Hutchins 128/7 3,033,194 5/1962 Lippert 128/2 3,253,524 5/1966 Ashizawa et al. 128/2 UX 3,289,669 12/1966 Dwyer et a1 128/2 3,401 ,684 9/1968 Dremann 128/2 FOREIGN PATENTS 1,451,726 7/1966 France 128/2 Primary Examiner-Richard A. Gaudet Assistant Examiner-Kyle L. Howell Attorney-Saxton Seward ABSTRACT: A biopsy tool that includes a rigid tip affixed to the distal end of a flexible intestinal intubation tube and is provided with a body portion having a longitudinal duct for the passage of an exchange guide and a radial cavity connected through the lumen of the tube to a vacuum source to draw a tissue sample thereinto. A pneumatically operable knife is 1ongitudinally reciprocable across the open end of the cavity to sever the tissue sample contained therein.
PATENTEUJUL 61971 3,590,808
SHEET 2 BF 2 INVENTOR.
BIOPSY TOOL THE INVENTION This invention relates generally to new and useful improvements in biopsy tools and particularly seeks to provide a novel biopsy tool that is affixed to and forms the distal tip of a flexible intestinal intubation tube, particularly of the type of intubation tube that is adapted to be advanced along a previously inserted exchange guide.
Heretofore it has been a long and difficult procedure to insert intubation tubes into the upper gastrointestinal tract through a patients nostril because it was necessary to slowly advance (over a period of several hours) the tube under fluoroscopic control while manipulating the patient through many difflcult postures or positions so that the distal end of the tube would follow the desired path of travel into the stomach and the several sections of the duodenum.
More recently techniques have been developed through which a soft woven catheter containing a proximally controllable distal tip spring guide may be fully inserted into a patient in from -l5 minutes under fluoroscopic control with a minimum of manipulation of the patient. After this initial insertion has been completed the spring guide is withdrawn from its associated catheter and is replaced by an exchange guide normally having a length somewhat greater than twice the inserted length of the catheter so that its exposed proximal end portion is sufficiently long to accept the full length of the intubation tube to be inserted. Then the catheter is withdrawn over the exchange guide, leaving the exchange guide in place ready to receive and lead the intubation tube into its fully inserted position.
A particularly suitable type of controllable tip spring guide for these techniques is disclosed and claimed in my copending application Ser. No. 563,927, filed June 29, 1966, now U.S. Pat. No. 3,452,742 and a particularly suitable exchange guide therefor is disclosed and claimed in my copending application Ser. No. 757,326, filed Sept. 4, 1968.
Although the above-described techniques and equipment are effective for the simple and rapid insertion of intubation tubes, the problem still remains of how to quickly and safely obtain biopsy samples, especially from locations in the upper gastrointestinal tract.
A past approach to solving this problem has been through the use of an intubation tube having its distal end closed by a rigid hollow tip with a radial aperture extending through the wall of the tip and of the tube. A wire-operated cylindrical knife is reciprocable within the tip to sever a tissue sample that has been drawn through the wall aperture by vacuum applied from within the tube.
Even though such knife-containing tubes are believed to be the best currently available for obtaining biopsy samples, several objections have been made thereto; principally that they can be inserted only through the above-mentioned hours long technique and cannot be used with the short time exchange guide technique, and that there is no way to control the total force of the vacuum so that there is a substantial risk of rupturing the tissue wall by drawing too much tissue through the wall aperture of the tube. Furthermore, there is no positive control over operation of the cylinder knife and it is difficult to determine whether or not a tissue sample has been fully and cleanly severed.
However, a biopsy tool constructed in accordance with this invention overcomes the abovediscussed problems and is fully compatible with the exchange guide technique of insertIon.
Therefore, an object of this invention is to provide a novel tool for taking biopsy samples, especially those from the upper gastrointestinal tract.
Another object of this invention is to provide a tool of the character stated that may be quickly and simply inserted to its final position over a prepositioned exchange guide.
Another object of this invention is to provide a tool of the character stated that includes a rigid tip affixed to the distal end of a flexible intubation tube and is provided with a body portion having a longitudinal duct for the passage of an exchange guide.
Another object of this invention is to provide a tool of the character stated in which the body portion thereof is provided with a radial cavity having a flat outer end and having its inner end connected through the lumen of the tube to a source of vacuum whereby a predetermined and controllable quantity of tissue sample is drawn into the cavity.
A further object of this invention is to provide a tool of the character stated that includes a pneumatically operated knife assembly removably attached to the tip body to clearly and positively sever the tissue sample contained within the radial cavity.
A further object of this invention is to provide a tool of the character stated in which a friction-reducing tube is positioned within the lumen of the tube and extends from the proximal end of the exchange guide-receiving duct in the tip body to the proximal end of the tube to facilitate advance of the tube over the guide.
A further object of this invention is to provide a tool of the character stated in which vacuum is applied to the radial cavity through the lumen of the tube and air under positive or negative pressure is supplied to the knife assembly for reciprocation of the knife through a separate tube positioned within the lumen of the tube and extending from the proximal end of the knife assembly to the proximal end of the tube.
A further object of this invention is to provide a tool of the character stated in which the reciprocable knife is a flat spearpointed blade arranged to have its point pass across a diameter of the body cavity whereby to first pierce the tissue sample and then clearly sever same as the knife is advanced.
With these and other objects in view, the nature of which will become apparent, the invention will be more fully understood by reference to the drawings, the accompanying detailed description and the appended claims.
IN THE DRAWINGS:
FIG. I is a side elevation of an assembled unit constructed in accordance with this invention;
FIG. 2 is a top plan view of the body 'of the biopsy tool;
FIG. 3 is a transverse section taken along line 3-3 of FIG. 2;
FIG. 4 is a side elevation of the body thereof;
FIG. 5 is a left end elevation of the body thereof;
FIG. 6 is a right end elevation of the body thereof;
FIG. 7 is a top plan view of the operating cylinder;
FIG. 8 is a side elevation of the operating cylinder;
FIG. 9 is a left end elevation of the cylinder;
FIG. 10 is a top plan view of the piston and knife blade assembly;
FIG. 11 is a side elevation of the piston and knife blade assembly; and
FIG. 12 is an isometric view of the cylinder retaining split sleeve.
Referring to the drawings in detail, the invention as illustrated is embodied in a biopsy tool assembly generally designated 5 and includes a body 6 (see FIGS. 26) machined from solid rod stock and having a rounded distal end 7 and a flanged proximal end 8 adapted to be secured within the distal end of a long flexible plastic catheter or intestinal intubation tube indicated at 9 by dotted lines on FIG. I.
A transverse channel 10 of rectangular cross section is machined across the top of the body 6 intermediate the ends thereof and has its flat bottom 11 forming a plane surface passing through the centerline of the body. The channel 10 is adapted to receive the knife guiding portion of an operating cylinder as will be hereinafter more fully explained. A longitudinal channel 12 of rectangular cross section is machined along the top of the body 6 at the proximal end thereof and has its flat bottom 13.l'ying ina plane slightly above that of the channel bottom 11.
The top of the distal end of the body 6 is machined to a flat surface 14 which in turn is machined to define an open-ended U-shaped pocket 15 having undercut lateral walls 16 to receive and guide the lateral edges of a knife blade as will be hereinafter more fully described.
A cylindrical cavity 17 for receiving and retaining a biopsy sample extends downwardly from the surface 14 and terminates at a plane slightly below that containing the centerline of the body 6. A short radial duct 18, located adjacent the wall of the cavity 17, has its upper end in open communication with the cavity and its lower end in open communication with a longitudinal duct 19 extending therefrom to the proximal end of the body 6. A fitting 20 is affixed within the proximal end of the duct 19 for connection through tubing (not shown) to a source of vacuum so that a biopsy sample may be drawn into the cavity "when the tool has become properly positioned within a patient.
A duct 21 is disposed in spaced parallel relation to the duct 19 and extends the full length of the body 6 to permit passage of an exchange guide therethrough. The proximal end of the duct 21 is provided with a fitting 22 for connection with the distal end of a friction-reducing tubular sheath (not shown) so that the tool and its associated intubation tube 9 may be more readily advanced over the exchange guide.
The body 6 also carries a pneumatically operable knife to sever the biopsy sample that has been drawn into the cavity 17. To this end (see FIGS. 7, 8 and 9) a cylinder having a generally hemicylindrical distal portion 23 and a tubular proximal extension 24, is fitted in the transverse and.longitudinal channels and 12 and is provided with a horizontal knife receiving and guiding slot 25, the bottom of which is coplanar with the bottom of the U-shaped pocket 15. The upper portion of the distal end portion 23 is bevelled as at 26 to reduce resistence when the tool is being inserted into a patient.
A cylindrical piston 27 is reciprocable within the bore of the cylinder 24 and is provided at its distal end with a flat knife blade 28 having a double bevel spear point cutting edge 29.
The cylinder and knife assembly is removably retained within the body 6 by a sleeve 30 (see FIG. I and 12) having a longitudinal split 31 of a width somewhat greater than the outside diameter of the tubular extension 24 so that when the sleeve is rotated until the split 31 is aligned therewith, the entire cylinder and knife assembly may be readily removed for cleaning and for replacement of the knife whenever it becomes too dull for further use. The proximal end 8 of the body 6 is provided with a round-headed stud 32 that is received within the split 31 when the sleeve 30 has been rotated to its cylinder-securing position. Springiness of the sleeve 30 permits the edge of the split 31 to ride up over the stud 32 when the sleeve is rotated.
A fitting 33 is affixed to the proximal end of the tubular extension 24 for connection through suitable tubing to an air syringe (not shown) for actuation of the piston 27 and its knife blade 28. Advancement of the plunger of the syringe will compress air to effect advancement of the knife to sever the tissue sample that has been drawn into the cavity 17, and withdrawal of the syringe plunger will create a vacuum to retract the knife. After the knife has thus been reciprocated one or two times, it is again advanced to cover the cavity 17 and the biopsy sample contained therein and is kept in this advanced position until the tool has been withdrawn from the patient, thus assuring retention of the sample and preventing it from being contaminated during withdrawal of the tool.
It will be appreciated from the foregoing description that the biopsy tool of this invention must be quite small, otherwise it would not be readily insertable throughthe designated internal passages. Typically, the body 6 would have an outside diameter in a range ofO. 10 inch to 0.65 inch, preferably about 0.25 inch and a length in a range of 0.30 inch to 2.0 inch,
preferabl about0.75 inch. h I
Thus I will be seen that this invention provides a novel biopsy tool in which a tissue sample is vacuum displaced within a cavity of fixed volume and severed by a reciprocable knife that can be actuated to close the sample-containing cavity as the tool is withdrawn. 7
It is, of course, to be understood that variations in arrangement and proportions of parts may be made within the scope of the appended claims.
1. A biopsy tool comprising a generally cylindrical body having a smoothly rounded distal end, a proximal end and a longitudinal axis, a plane surface extending proximally from the distal end of said body, a sample-receiving cavity extending into said body from said plane surface, aflat-bladed knife reciprocable across said cavity along said surface, knife actuating means adjacent to said surface, a first bore extending axially from end-to-end of the body and open at both ends, and a second bore extending axially from the proximal end of the body to a point adjacent said cavity and being in communication with said cavity.
2. A biopsy tool according to claim 1 in which said surface lies parallel to said axis and said knife is reciprocable axially.
3. A biopsy tool according to claim 1 in which the knife actuating means includes a piston fixed to the knife, a cylinder adapted to receive said piston and a fitting for connection of the cylinder to a source of actuating fluid.
4. A biopsy tool according to claim 3 in which the cylindrical body is longitudinally recessed adjacent its proximal end, the cylinder is formed in the distal end of a separate cylinder block, said block is fitted in said longitudinal recess, and which includes releasable means for holding said block in said recess.
5. A biopsy tool according to claim 4 in which said releasable means is a rotatable collar.
6. A biopsy tool according to claim 2 in which the knife has parallel sides and a double bevel spear point cutting edge, the distance between said sides being greater than the corresponding dimension of the sample-receiving cavity.
7. A biopsy tool according to claim 6 in which the plane surface is bounded by a U-shaped rim around the distal and lateral edges of said surface, the lateral portions of said rim being parallel and spaced to guide freely the parallel sides of the knife.
8. A biopsy tool according to claim 4 in which the cylinder block is provided with a distally extending portion slotted in a plane parallel to the axis of the cylinder, the knife being slidable in said slot.
9. A biopsy tool according to claim 1 which includes a fitting at the proximal end of said second bore for connection thereof to a source of vacuum.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US2212133 *||4 May 1937||20 Ago 1940||Fred J Melges||Surgical instrument|
|US2684069 *||5 Jul 1952||20 Jul 1954||Donaldson||Precision linear-fracture instrument for heart valve surgery|
|US2708437 *||31 Mar 1952||17 May 1955||Elizabeth Painter Hutchins||Surgical instrument|
|US3033194 *||8 Nov 1960||8 May 1962||Lippert Henry E||Biopsy capsule and apparatus|
|US3253524 *||2 Ene 1963||31 May 1966||Olympus Optical Co||Flexible tube assembly|
|US3289669 *||25 Feb 1964||6 Dic 1966||Dwyer Donald J||Biopsy capsule arrangement|
|US3401684 *||16 Dic 1965||17 Sep 1968||Weck & Co Edward||Biopsy capsules|
|FR1451726A *||Título no disponible|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US4620547 *||28 Dic 1984||4 Nov 1986||Richard Wolf Gmbh||Instrument for sampling tissue specimens|
|US4781202 *||31 Ago 1987||1 Nov 1988||Janese Woodrow W||Biopsy cannula|
|US5526822 *||24 Mar 1994||18 Jun 1996||Biopsys Medical, Inc.||Method and apparatus for automated biopsy and collection of soft tissue|
|US5542432 *||1 Feb 1994||6 Ago 1996||Symbiosis Corporation||Endoscopic multiple sample bioptome|
|US5649547 *||10 Feb 1995||22 Jul 1997||Biopsys Medical, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US5665099 *||12 May 1995||9 Sep 1997||Pilo; Giuseppe||Surgical scalpel with automatically retractable blade|
|US5674232 *||20 Sep 1996||7 Oct 1997||Halliburton; Alexander George||Catheter and method of use thereof|
|US5775333 *||13 May 1996||7 Jul 1998||Ethicon Endo-Surgery, Inc.||Apparatus for automated biopsy and collection of soft tissue|
|US5810744 *||18 Nov 1997||22 Sep 1998||Boston Scientific Corporation||Instrument for collecting multiple biopsy specimens|
|US5817115 *||4 Dic 1995||6 Oct 1998||Chiron Vision Corporation||Apparatus for resecting corneal tissue|
|US5860993 *||25 Sep 1996||19 Ene 1999||Medworks Corp.||Suture cutter|
|US5871453 *||29 Ago 1996||16 Feb 1999||Boston Scientific Corporation||Moveable sample tube multiple biopsy sampling device|
|US5895370 *||7 Ene 1997||20 Abr 1999||Vidamed, Inc.||Medical probe (with stylets) device|
|US5897507 *||25 Nov 1996||27 Abr 1999||Symbiosis Corporation||Biopsy forceps instrument having irrigation and aspiration capabilities|
|US5928164 *||9 Ene 1998||27 Jul 1999||Ethicon Endo-Surgery, Inc.||Apparatus for automated biopsy and collection of soft tissue|
|US5944673 *||14 May 1998||31 Ago 1999||Ethicon Endo-Surgery, Inc.||Biopsy instrument with multi-port needle|
|US5951488 *||3 Dic 1996||14 Sep 1999||Symbiosis Corporation||Endoscopic multiple sample bioptome|
|US5964716 *||14 May 1998||12 Oct 1999||Ethicon Endo-Surgery, Inc.||Method of use for a multi-port biopsy instrument|
|US5980469 *||9 Ene 1998||9 Nov 1999||Ethicon Endo-Surgery, Inc.||Method and apparatus for automated biopsy and collection of soft tissue|
|US6017316 *||18 Jun 1997||25 Ene 2000||Biopsys Medical||Vacuum control system and method for automated biopsy device|
|US6019733 *||18 Sep 1998||1 Feb 2000||United States Surgical Corporation||Biopsy apparatus and method|
|US6050955 *||18 Sep 1998||18 Abr 2000||United States Surgical Corporation||Biopsy apparatus and method|
|US6053877 *||17 Nov 1998||25 Abr 2000||Boston Scientific Corporation||Movable sample tube multiple biopsy sampling device|
|US6077230 *||14 May 1998||20 Jun 2000||Ethicon Endo-Surgery, Inc.||Biopsy instrument with removable extractor|
|US6142955 *||20 Feb 1998||7 Nov 2000||United States Surgical Corporation||Biopsy apparatus and method|
|US6142956 *||3 Feb 1997||7 Nov 2000||Symbiosis Corporation||Proximal actuation handle for a biopsy forceps instrument having irrigation and aspiration capabilities|
|US6142957 *||27 Ene 1997||7 Nov 2000||Boston Scientific Corporation||Multiple biopsy sampling device|
|US6174292||24 Feb 1999||16 Ene 2001||Symbiosis Corporation||Biopsy forceps instrument having irrigation and aspiration capabilities|
|US6193671||4 May 1998||27 Feb 2001||Symbiosis Corporation||Endoscopic multiple sample bioptome with enhanced biting action|
|US6193673||19 Feb 1999||27 Feb 2001||United States Surgical Corporation||Biopsy instrument driver apparatus|
|US6206847 *||17 Mar 1999||27 Mar 2001||Vidamed, Inc.||Medical probe device|
|US6231522||18 Feb 2000||15 May 2001||Ethicon Endo-Surgery, Inc.||Biopsy instrument with breakable sample segments|
|US6241687||18 Feb 2000||5 Jun 2001||Ethicon Endo-Surgery, Inc.||Method of use for a biopsy instrument with breakable sample segments|
|US6402701||17 Mar 2000||11 Jun 2002||Fna Concepts, Llc||Biopsy needle instrument|
|US6428486||21 Dic 2000||6 Ago 2002||Ethicon Endo-Surgery, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US6436054||24 Nov 1999||20 Ago 2002||United States Surgical Corporation||Biopsy system|
|US6464661||27 Mar 2001||15 Oct 2002||Vidamed, Inc.||Medical probe with stylets|
|US6488636||7 Jun 2001||3 Dic 2002||United States Surgical Corporation||Biopsy apparatus|
|US6544194||22 Jun 2000||8 Abr 2003||Symbiosis Corporation||Proximal actuation handle for a biopsy forceps instrument having irrigation and aspiration capabilities|
|US6554779||16 Feb 2001||29 Abr 2003||United States Surgical Corporation||Biopsy instrument driver apparatus|
|US6561988||20 Nov 2000||13 May 2003||Symbiosis Corporation||Endoscopic multiple sample bioptome with enhanced biting action|
|US6689072||13 Nov 2001||10 Feb 2004||Leopold S. Kaplan||Biopsy needle instrument|
|US6712773||11 Sep 2000||30 Mar 2004||Tyco Healthcare Group Lp||Biopsy system|
|US6832990||27 Ago 2002||21 Dic 2004||Symbiosis Corporation||Biopsy instrument having aspiration capabilities|
|US6860860||19 Nov 2001||1 Mar 2005||Tyco Healthcare Group, Lp||Tissue sampling and removal apparatus and method|
|US6926676||16 Oct 2001||9 Ago 2005||Boston Scientific Scimed, Inc.||Biopsy instrument having irrigation and aspiration capabilities|
|US7189207||23 May 2003||13 Mar 2007||Tyco Healthcare Group Lp||Biopsy system having a single use loading unit operable with a trocar driver, a knife driver and firing module|
|US7204811||7 Jul 2004||17 Abr 2007||Boston Scientific Miami Corporation||Proximal actuation handle for a biopsy forceps instrument having irrigation and aspiration capabilities|
|US7226424||11 Feb 2003||5 Jun 2007||Ethicon Endo-Surgery, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US7297121||13 Jun 2005||20 Nov 2007||Boston Scientific Scimed, Inc.||Biopsy instrument having irrigation and aspiration capabilities|
|US7297147 *||9 Mar 2006||20 Nov 2007||Gary Karlin Michelson||Method for cutting bone or cartilage with a rongeur|
|US7347828||16 Oct 2001||25 Mar 2008||Boston Scientific Miami Corporation||Suction adapter for medical instrument|
|US7513877||3 Jun 2004||7 Abr 2009||Tyco Healthcare Group Lp||Tissue sampling and removal apparatus and method|
|US7588545||10 Sep 2003||15 Sep 2009||Boston Scientific Scimed, Inc.||Forceps and collection assembly with accompanying mechanisms and related methods of use|
|US7591790||30 Jul 2007||22 Sep 2009||Stryker Puerto Rico Limited||Micro-invasive device|
|US7648466||24 Oct 2007||19 Ene 2010||Ethicon Endo-Surgery, Inc.||Manually rotatable piercer|
|US7762960||13 May 2005||27 Jul 2010||Boston Scientific Scimed, Inc.||Biopsy forceps assemblies|
|US7794411||31 Oct 2007||14 Sep 2010||Devicor Medical Products, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US7833167||20 Mar 2007||16 Nov 2010||Boston Scientific Miami Corporation|
|US7909850||28 Dic 2005||22 Mar 2011||Boston Scientific Scimed, Inc.||Forceps for medical use|
|US7918803||4 Ago 2009||5 Abr 2011||Devicor Medical Products, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US7922723 *||9 Jun 2003||12 Abr 2011||Gary Karlin Michelson||Method for using a surgical rongeur|
|US7942896||25 Nov 2003||17 May 2011||Scimed Life Systems, Inc.||Forceps and collection assembly and related methods of use and manufacture|
|US7981050||6 Feb 2007||19 Jul 2011||Devicor Medical Products, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US8083686||5 Ago 2009||27 Dic 2011||Boston Scientific Scimed, Inc.||Forceps and collection assembly with accompanying mechanisms and related methods of use|
|US8128577||16 Ene 2007||6 Mar 2012||Tyco Healthcare Group Lp||Biopsy system|
|US8241290||12 Abr 2011||14 Ago 2012||Michelson Gary K||Surgical rongeur|
|US8317726||15 Jun 2010||27 Nov 2012||Boston Scientific Scimed, Inc.||Biopsy forceps assemblies|
|US8439940||22 Dic 2010||14 May 2013||Cabochon Aesthetics, Inc.||Dissection handpiece with aspiration means for reducing the appearance of cellulite|
|US8460205||29 Nov 2011||11 Jun 2013||Boston Scientific Scimed, Inc.||Forceps and collection assembly with accompanying mechanisms and related methods of use|
|US8518069||25 May 2010||27 Ago 2013||Cabochon Aesthetics, Inc.||Dissection handpiece and method for reducing the appearance of cellulite|
|US8591435||11 Mar 2011||26 Nov 2013||Devicor Medical Products, Inc.||Methods and devices for biopsy and collection of soft tissue|
|US8672859||23 Oct 2012||18 Mar 2014||Boston Scientific Scimed, Inc.||Biopsy forceps assemblies|
|US8790276||14 Mar 2013||29 Jul 2014||Devicor Medical Products, Inc.||Methods and devices for biopsy and collection of soft tissue|
|US8808199||14 Mar 2013||19 Ago 2014||Devicor Medical Products, Inc.||Methods and devices for biopsy and collection of soft tissue|
|US8894678||29 May 2014||25 Nov 2014||Ulthera, Inc.||Cellulite treatment methods|
|US8900261||29 May 2014||2 Dic 2014||Ulthera, Inc.||Tissue treatment system for reducing the appearance of cellulite|
|US8900262||29 May 2014||2 Dic 2014||Ulthera, Inc.||Device for dissection of subcutaneous tissue|
|US8906054||29 May 2014||9 Dic 2014||Ulthera, Inc.||Apparatus for reducing the appearance of cellulite|
|US8920452||29 May 2014||30 Dic 2014||Ulthera, Inc.||Methods of tissue release to reduce the appearance of cellulite|
|US8979881||29 May 2014||17 Mar 2015||Ulthera, Inc.||Methods and handpiece for use in tissue dissection|
|US9005229||12 Dic 2012||14 Abr 2015||Ulthera, Inc.||Dissection handpiece and method for reducing the appearance of cellulite|
|US9011473||12 Dic 2012||21 Abr 2015||Ulthera, Inc.||Dissection handpiece and method for reducing the appearance of cellulite|
|US9039722||27 Feb 2013||26 May 2015||Ulthera, Inc.||Dissection handpiece with aspiration means for reducing the appearance of cellulite|
|US9044259||22 Dic 2014||2 Jun 2015||Ulthera, Inc.||Methods for dissection of subcutaneous tissue|
|US9078688||22 Dic 2014||14 Jul 2015||Ulthera, Inc.||Handpiece for use in tissue dissection|
|US20050054945 *||10 Sep 2003||10 Mar 2005||Scimed Life Systems, Inc||Forceps and collection assembly with accompanying mechanisms and related methods of use|
|US20050080441 *||10 Oct 2003||14 Abr 2005||Duke University||Surgical instruments which are especially useful for ophthalmic surgical procedures, and methods of making the same|
|US20050209530 *||20 May 2005||22 Sep 2005||Stryker Puerto Rico Limited||Micro-invasive tissue removal device|
|US20050245841 *||13 Jun 2005||3 Nov 2005||Vincent Turturro||Biopsy instrument having irrigation and aspiration capabilities|
|EP0647121A1 *||15 Jun 1993||12 Abr 1995||MANN, David||Apparatus and method to obtain arterial biopsies|
|EP0751744A1 *||20 Mar 1995||8 Ene 1997||Biopsys Medical, Inc.||Method and apparatus for automated biopsy and collection of soft tissue|
|EP1031320A1 *||15 Jun 1993||30 Ago 2000||MANN, David||Method for obtaining an arterial biopsy|
|EP2382923A1||28 Abr 2011||2 Nov 2011||Sanovas Inc.||Pressure/vaccum actuated biopsy device|
|WO1994028803A1 *||10 Jun 1994||22 Dic 1994||Hec Medical Arts Ltd||Catheter and method of use thereof|
|WO1999007288A1||8 Ago 1997||18 Feb 1999||Johnson Arthur C||Multiple sample biopsy forceps|
|Clasificación de EE.UU.||600/565, 606/171|
|Clasificación internacional||A61B17/30, A61B10/00, A61B17/00, A61B10/02, A61B17/22, A61B10/04|
|Clasificación cooperativa||A61B17/320783, A61B2017/00535, A61B2017/306, A61B10/04|