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Número de publicaciónUS3598122 B1
Tipo de publicaciónConcesión
Fecha de publicación23 Nov 1982
Fecha de presentación1 Abr 1969
Fecha de prioridad1 Abr 1969
Número de publicaciónUS 3598122 B1, US 3598122B1, US-B1-3598122, US3598122 B1, US3598122B1
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos: USPTO, Cesión de USPTO, Espacenet

US 3598122 B1
Resumen  disponible en
Descripción  disponible en
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Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US3710795 *29 Sep 197016 Ene 1973Alza CorpDrug-delivery device with stretched, rate-controlling membrane
US3731683 *4 Jun 19718 May 1973Alza CorpBandage for the controlled metering of topical drugs to the skin
US3797494 *9 Ago 197119 Mar 1974Alza CorpBandage for the administration of drug by controlled metering through microporous materials
US3807398 *19 Sep 197230 Abr 1974B GruczaOcular implant
US3854480 *2 Jun 197017 Dic 1974Alza CorpDrug-delivery system
US3896819 *30 Sep 197129 Jul 1975Alza CorpIUD having a replenishing drug reservoir
US3951622 *4 Dic 197420 Abr 1976Wilk Immanuel JTime release perfume method and device
US3960150 *15 Sep 19751 Jun 1976Alza CorporationBioerodible ocular device
US3961628 *21 Abr 19758 Jun 1976Alza CorporationOcular drug dispensing system
US3964482 *17 May 197122 Jun 1976Alza CorporationDrug delivery device
US3981303 *31 Jul 197521 Sep 1976Alza CorporationBioerodible ocular device
US3986510 *1 Ago 197519 Oct 1976Alza CorporationBioerodible ocular device
US3993071 *24 Jul 197523 Nov 1976Alza CorporationBioerodible ocular device
US3993072 *17 Oct 197523 Nov 1976Alza CorporationMicroporous drug delivery device
US3993073 *3 Mar 197523 Nov 1976Alza CorporationNovel drug delivery device
US3996934 *9 Ago 197114 Dic 1976Alza CorporationMedical bandage
US4191743 *2 Nov 19774 Mar 1980Merck Patent Gesellschaft Mit Beschrankter HaftungAntibacterial wound dressing
US4201211 *12 Jul 19776 May 1980Alza CorporationTherapeutic system for administering clonidine transdermally
US4286592 *4 Feb 19801 Sep 1981Alza CorporationTherapeutic system for administering drugs to the skin
US4336243 *4 May 198122 Jun 1982G. D. Searle & Co.Transdermal nitroglycerin pad
US4460371 *20 Dic 198217 Jul 1984Dennison Manufacturing CompanySilicone pressure sensitive adhesive and uses
US4563184 *17 Oct 19837 Ene 1986Bernard KorolSynthetic resin wound dressing and method of treatment using same
US4568343 *9 Oct 19844 Feb 1986Alza CorporationSkin permeation enhancer compositions
US4594240 *7 Sep 198310 Jun 1986Teikoku Seiyaku Kabushiki KaishaSheet-shape adhesive preparation
US4597961 *23 Ene 19851 Jul 1986Etscorn Frank TTranscutaneous application of nicotine
US4608249 *2 Nov 198226 Ago 1986Nitto Electric Industrial Co., Ltd.Hydrophilic therapeutic material
US4614787 *13 Nov 198430 Sep 1986Thermedics, Inc.Drug dispensing wound dressing
US4615697 *9 Nov 19847 Oct 1986Bio-Mimetics, Inc.Bioadhesive compositions and methods of treatment therewith
US4638043 *23 Ago 198520 Ene 1987Thermedics, Inc.Drug release system
US4649075 *9 Ago 198410 Mar 1987Leonora JostTransdermal and transmucosal vortexed foam devices and the method of making
US4666441 *17 Dic 198519 May 1987Ciba-Geigy CorporationMulticompartmentalized transdermal patches
US4704282 *29 Jun 19843 Nov 1987Alza CorporationTransdermal therapeutic system having improved delivery characteristics
US4719226 *31 Dic 198412 Ene 1988Nitto Electric Industrial Co., Ltd.Percutaneous absorption type preparation and process for preparing the same
US4725439 *13 Ene 198616 Feb 1988Alza CorporationTransdermal drug delivery device
US4727868 *20 May 19871 Mar 1988Thermedics, Inc.Anisotropic wound dressing
US4738848 *4 Jun 198619 Abr 1988Nitto Electric Industrial Co., Ltd.Anti-inflammatory analgesic adhesive preparation
US4743249 *10 Jun 198710 May 1988Ciba-Geigy Corp.Dermal and transdermal patches having a discontinuous pattern adhesive layer
US4746515 *26 Feb 198724 May 1988Alza CorporationSkin permeation enhancer compositions using glycerol monolaurate
US4751133 *11 May 198714 Jun 1988Thermedics, Inc.Medical patches and processes for producing same
US4752478 *17 Dic 198421 Jun 1988Merck & Co., Inc.Transdermal system for timolol
US4764378 *10 Feb 198616 Ago 1988Zetachron, Inc.Buccal drug dosage form
US4764379 *24 Ago 198716 Ago 1988Alza CorporationTransdermal drug delivery device with dual permeation enhancers
US4767787 *24 Mar 198630 Ago 1988Kaken Pharmaceutical Co., Ltd.Sheet-shape adhesive preparation
US4769028 *17 Jul 19866 Sep 1988Lohmann Gmbh & Co. KgPharmaceutical product, in medical bandage form
US4781924 *9 Nov 19871 Nov 1988Alza CorporationTransdermal drug delivery device
US4788062 *26 Feb 198729 Nov 1988Alza CorporationTransdermal administration of progesterone, estradiol esters, and mixtures thereof
US4795436 *22 Sep 19863 Ene 1989Bio-Mimetics, Inc.Bioadhesive composition and method of treatment therewith
US4797284 *12 Mar 198610 Ene 1989Merck & Co., Inc.Transdermal drug delivery system
US4812305 *9 Nov 198714 Mar 1989Vocal Rodolfo SWell medicine strip
US4816258 *26 Feb 198728 Mar 1989Alza CorporationTransdermal contraceptive formulations
US4820720 *29 Mar 198811 Abr 1989Alza CorporationTransdermal drug composition with dual permeation enhancers
US4834979 *14 Dic 198730 May 1989Alza CorporationMedical bandage for administering beneficial drug
US4837027 *9 Ago 19886 Jun 1989Alza CorporationTransdermal drug delivery device
US4839174 *5 Oct 198713 Jun 1989Pharmetrix CorporationNovel transdermal nicotine patch
US4840796 *22 Abr 198820 Jun 1989Dow Corning CorporationBlock copolymer matrix for transdermal drug release
US4844903 *6 Nov 19874 Jul 1989Mepha AgProcess for the production of an adhesive plaster
US4863738 *23 Nov 19875 Sep 1989Alza CorporationSkin permeation enhancer compositions using glycerol monooleate
US4865848 *26 Feb 198712 Sep 1989Alza CorporationSkin permeation enhancer compositions using sucrose esters
US4877618 *18 Mar 198831 Oct 1989Reed Jr Fred DTransdermal drug delivery device
US4879275 *27 May 19887 Nov 1989Nelson Research & Development Co.Penetration enhancers for transdermal delivery of systemic agent
US4880690 *9 Sep 198814 Nov 1989Thermedics, Inc.Perfume patch
US4885154 *1 Mar 19885 Dic 1989Alza CorporationMethod for reducing sensitization or irritation in transdermal drug delivery and means therefor
US4889720 *31 Ago 198726 Dic 1989Teikoku Seiyaku Kabushiki KaishaSustained release dosage form for use with tissues of the oral cavity
US4898592 *16 Sep 19886 Feb 1990Latzke Arno WMeans for the application of transdermally absorbable active substances
US4900552 *30 Mar 198813 Feb 1990Watson Laboratories, Inc.Mucoadhesive buccal dosage forms
US4900555 *13 Oct 198813 Feb 1990Alza CorporationSkin permeation enhancer compositions using sucrose esters
US4906475 *16 Feb 19886 Mar 1990Paco Pharmaceutical ServicesEstradiol transdermal delivery system
US4908027 *12 Sep 198613 Mar 1990Alza CorporationSubsaturated transdermal therapeutic system having improved release characteristics
US4909244 *26 Nov 198620 Mar 1990The Kendall CompanyHydrogel wound dressing
US4917688 *27 Jun 198817 Abr 1990Nelson Research & Development Co.Bandage for transdermal delivery of systemically-active drug
US4917895 *14 Jul 198817 Abr 1990Alza CorporationTransdermal drug delivery device
US4920101 *30 Sep 198724 Abr 1990Nelson Research & Development Co.Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
US4925671 *7 Jul 198415 May 1990Flexcon Company, Inc.Silicone pressure sensitive adhesive and uses
US4940586 *13 Oct 198810 Jul 1990Alza CorporationSkin permeation enhancer compositions using sucrose esters
US4942037 *2 Jun 198817 Jul 1990Merck & Co., Inc.Transdermal delivery systems
US4943435 *28 Oct 198824 Jul 1990Pharmetrix CorporationProlonged activity nicotine patch
US4951657 *22 Abr 198828 Ago 1990Dow Corning CorporationHeat sealable membrane for transdermal drug release
US4956171 *21 Jul 198911 Sep 1990Paco Pharmaceutical Services, Inc.Transdermal drug delivery using a dual permeation enhancer and method of performing the same
US4959208 *28 Oct 198825 Sep 1990Ppg Industries, Inc.Active agent delivery device
US4969871 *15 Feb 198913 Nov 1990Alza CorporationIntravenous system for delivering a beneficial agent
US4973468 *22 Mar 198927 Nov 1990Cygnus Research CorporationSkin permeation enhancer compositions
US4979946 *7 Abr 198925 Dic 1990The Kendall CompanyEnvironmental absorbent dressing
US4985016 *15 Feb 198915 Ene 1991Alza CorporationIntravenous system for delivering a beneficial agent
US4994049 *15 Nov 198919 Feb 1991Latzke Arno WDevice for applying a substance to the skin
US4997655 *22 Jun 19885 Mar 1991Biogal GyogyszergyarPharmaceutical formulation ensuring the transdermal absorption of the active ingredient and process for preparing same
US5000956 *8 Jul 198819 Mar 1991Alza CorporationPrevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5004610 *14 Jun 19902 Abr 1991Alza CorporationSubsaturated nicotine transdermal therapeutic system
US5034386 *17 Ago 198823 Jul 1991Whitby Research, Inc.Methods for administration using 1-substituted azacycloalkanes
US5035886 *10 May 199030 Jul 1991Ppg Industries, Inc.Active agent delivery device
US5045059 *15 Ago 19903 Sep 1991Alza CorporationIntravenous system for delivering a beneficial agent
US5049387 *9 Jun 198917 Sep 1991Alza CorporationInducing skin tolerance to a sensitizing drug
US5053227 *12 Jun 19901 Oct 1991Cygnus Therapeutic SystemsSkin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5059189 *8 Sep 198722 Oct 1991E. R. Squibb & Sons, Inc.Method of preparing adhesive dressings containing a pharmaceutically active ingredient
US5059426 *12 Jun 199022 Oct 1991Cygnus Therapeutic SystemsSkin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5068226 *30 Abr 199026 Nov 1991Cyclex, Inc.Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies
US5071645 *20 Mar 199110 Dic 1991Ppg Industries, Inc.Process of producing an active agent delivery device
US5071656 *14 Nov 198810 Dic 1991Alza CorporationDelayed onset transdermal delivery device
US5077054 *27 Nov 199031 Dic 1991Alza CorporationPrevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5118509 *30 Ago 19912 Jun 1992Alza CorporationInducing skin tolerance to a sensitizing drug
US5120545 *3 Ago 19909 Jun 1992Alza CorporationReduction or prevention of sensitization to drugs
US5124157 *18 Ago 198923 Jun 1992Cygnus Therapeutic SystemsMethod and device for administering dexmedetomidine transdermally
US5130139 *6 Jul 199014 Jul 1992Alza CorporationReduction or prevention of skin irritation by drugs
US5141750 *14 Nov 198825 Ago 1992Alza CorporationDelayed onset transdermal delivery device
US5149539 *15 Nov 199122 Sep 1992Alza CorporationReduction or prevention of sensitization to drugs
US5160320 *14 Feb 19903 Nov 1992Alza CorporationIntravenous system for delivering a beneficial agent
US5160741 *13 Nov 19913 Nov 1992Alza CorporationReduction or prevention of skin irritation by drugs
US5171576 *30 Ago 199115 Dic 1992Alza CorporationPrevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5173302 *28 Sep 199022 Dic 1992Medtronic, Inc.Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs
US5189986 *23 Sep 19912 Mar 1993Alza CorporationVeterinary transdermal active agent delivery device
US5196202 *2 Oct 198923 Mar 1993Teikoku Seiyaku Kabushiki KaishaSustained release dosage form
US5198223 *9 Mar 199230 Mar 1993Alza CorporationTransdermal formulations, methods and devices
US5203768 *24 Jul 199120 Abr 1993Alza CorporationTransdermal delivery device
US5204339 *6 Ago 199020 Abr 1993Whitby Research, Inc.Penetration enhancers for transdermal delivery of systemic agents
US5217718 *17 Sep 19918 Jun 1993Cygnus Therapeutic SystemsMethod and device for administering dexmedetomidine transdermally
US5223261 *31 Dic 199129 Jun 1993Riker Laboratories, Inc.Transdermal estradiol delivery system
US5230896 *12 Oct 198927 Jul 1993Warner-Lambert CompanyTransdermal nicotine delivery system
US5234690 *23 Ago 199110 Ago 1993Cygnus Therapeutic SystemsTransdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
US5250028 *9 Ago 19915 Oct 1993Alza CorporationIntravenous system for delivering a beneficial agent using permeability enhancers
US5254346 *23 Feb 198919 Oct 1993Tucker Mark JOcclusive body for administering a physiologically active substance
US5268179 *14 Feb 19927 Dic 1993Ciba-Geigy CorporationUltrasonically sealed transdermal drug delivery systems
US5273755 *23 Ago 199128 Dic 1993Cygnus Therapeutic SystemsTransdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset
US5273756 *23 Ago 199128 Dic 1993Cygnus Therapeutic SystemsTransdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset
US5284660 *21 Ago 19928 Feb 1994Alza CorporationDelayed onset transdermal delivery device
US5286491 *18 May 199215 Feb 1994Alza CorporationPrevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5286748 *27 Nov 199115 Feb 1994Eby Iii George AGeneral method of shortening the duration of common colds by application of medicaments to tissues of oral cavity
US5298257 *19 Mar 199229 Mar 1994Elan Transdermal LimitedMethod for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
US5304379 *3 Nov 199219 Abr 1994Alza CorporationMethod for reducing sensitization or irritation in transdermal drug delivery and means therefor
US5314694 *26 Mar 199324 May 1994Alza CorporationTransdermal formulations, methods and devices
US5320850 *12 Feb 199314 Jun 1994Alza CorporationTransdermal delivery of the gestogen ST-1435 and devices therefor
US5322695 *25 Ago 199221 Jun 1994Hercon Laboratories CorporationMoisture-vapor-permeable dressing
US5342623 *18 Jun 199330 Ago 1994Alza CorporationSubsaturated transdermal therapeutic system having improved release characteristics
US5364628 *22 Oct 199315 Nov 1994Sandoz Ltd.Pharmaceutical compositions
US5364634 *8 Nov 199115 Nov 1994Southwest Research InstituteControlled-release PH sensitive capsule and adhesive system and method
US5376377 *17 Dic 199227 Dic 1994Alza CorporationTransdermal contraceptive formulations, methods and devices
US5378730 *3 Dic 19923 Ene 1995Alza CorporationPermeation enhancer comprising ethanol and monoglycerides
US5402777 *3 Jun 19924 Abr 1995Alza CorporationMethods and devices for facilitated non-invasive oxygen monitoring
US5411740 *8 Feb 19942 May 1995Alza CorporationTransdermal administration of oxybutynin
US5445607 *15 Oct 199229 Ago 1995Theratech, Inc.Iontophoresis device and method using a rate-controlling electrically sensitive membrane
US5451407 *21 Jun 199319 Sep 1995Alza CorporationReduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
US5464387 *27 Oct 19947 Nov 1995Alza CorporationTransdermal delivery device
US5490415 *15 Abr 199413 Feb 1996Pharmetrix CorporationDiffusion test apparatus and method
US5498417 *12 May 199412 Mar 1996Coating Sciences, Inc.Transdermal delivery of appetite suppressant drug
US5500222 *15 Feb 199519 Mar 1996Alza CorporationTransdermal administration of oxybutynin
US5508038 *16 Abr 199016 Abr 1996Alza CorporationPolyisobutylene adhesives for transdermal devices
US5508039 *16 Oct 199216 Abr 1996Alza CorporationControlled transdermal administration of melatonin
US5512292 *21 Dic 199430 Abr 1996Alza CorporationTransdermal contraceptive formulations methods and devices
US5536263 *30 Mar 199416 Jul 1996Lectec CorporationNon-occulusive adhesive patch for applying medication to the skin
US5560922 *5 Jun 19951 Oct 1996Rutgers, The State University Of New JerseyTransdermal absorption dosage unit using a polyacrylate adhesive polymer and process
US5589192 *5 Dic 199431 Dic 1996Lintec CorporationGel pharmaceutical formulation for local anesthesia
US5599554 *19 Mar 19964 Feb 1997The Procter & Gamble CompanyTreatment of nicotine craving and/or smoking withdrawal symptoms
US5633008 *12 Ago 199327 May 1997Osborne; James L.Method of administering nicotine transdermally
US5633009 *12 Nov 199327 May 1997Sano CorporationTransdermal administration of azapirones
US5641504 *20 May 199224 Jun 1997Alza CorporationSkin permeation enhancer compositions using glycerol monolinoleate
US5650165 *7 Nov 199522 Jul 1997Nitto Denko CorporationPercutaneous absorption preparation
US5662925 *26 Abr 19962 Sep 1997Theratech, Inc.Transdermal delivery system with adhesive overlay and peel seal disc
US5662928 *21 Abr 19952 Sep 1997Ciba-Geigy CorporationMethod for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system
US5691377 *14 Jul 199425 Nov 1997University Of Maryland Eastern Shore And University Of Maryland College ParkUse of N-methyl-aspartic acid for enhancing growth and altering body composition
US5705186 *5 Ene 19956 Ene 1998Lts Lohmann Therapie-Systeme GmbhPharmaceutical composition for the systemic transdermal administration having the active substance morphine-6-glucuronide
US5707663 *16 May 199513 Ene 1998Alza CorporationSustained antiepileptic therapy
US5733255 *15 Oct 199631 Mar 1998Novartis Finance CorporationThermopile powered transdermal drug delivery device
US5741510 *8 Abr 199621 Abr 1998Lectec CorporationAdhesive patch for applying analgesic medication to the skin
US5747065 *29 Sep 19945 May 1998Lee; Eun SooMonoglyceride/lactate ester permeation enhancer for oxybutynin
US5750137 *29 Sep 199412 May 1998Taskovich; Lina TormenMonoglyceride/lactate ester permeation enhancer
US5763425 *8 Ene 19979 Jun 1998Gundersen Clinic, Ltd.Suppression of thromboxane levels by percutaneous administration of aspirin
US5770220 *23 Nov 199423 Jun 1998Lts Lohmann Therapie Systeme GmbhActive substance-containing patch
US5785991 *7 Jun 199528 Jul 1998Alza CorporationSkin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US5788983 *14 Sep 19924 Ago 1998Rutgers, The State University Of New JerseyTransdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5804214 *6 Jul 19948 Sep 1998Cygnus, Inc.Monolithic matrix transdermal delivery system for delivering ketorolac tromethamine
US5817331 *7 Jun 19956 Oct 1998Sano CorporationTransdermal administration of azapirones
US5820876 *6 Jun 199513 Oct 1998Lts Lohmann Therapie-Systeme Gmbh & Co. KgTransdermal therapeutic system
US5837280 *7 Jun 199517 Nov 1998Sano CorporationTransdermal administration of azapirones
US5840327 *15 Ago 199624 Nov 1998Alza CorporationTransdermal drug delivery device having enhanced adhesion
US5843468 *13 May 19961 Dic 1998Alza CorporationSkin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US5861170 *22 Mar 199419 Ene 1999Lts Lohmann Therapie-Systeme Gmbh & Co. KgAcetylsalicyclic acid-containing transdermal application system for antithrombotic therapy
US5882674 *3 Jun 199516 Mar 1999Lts Lohmann Therapie-Systeme GmbhTransdermal therapeutic system comprising active substances representing carbon monoxide sources
US5882676 *26 May 199516 Mar 1999Alza CorporationSkin permeation enhancer compositions using acyl lactylates
US5895660 *6 Dic 199420 Abr 1999Lts Lohmann Therapie-Systeme GmbhDeuterated active substances in transdermal application
US5900250 *30 Abr 19984 May 1999Alza CorporationMonoglyceride/lactate ester permeation enhancer for oxybutnin
US5919478 *24 Jun 19946 Jul 1999Alza CorporationIncorporating poly-N-vinyl amide in a transdermal system
US5942243 *12 May 199824 Ago 1999Polytherapeutics, Inc.Mucoadhesive compositions for administration of biologically active agents to animal tissue
US5962011 *24 Jun 19975 Oct 1999Schering-Plough Healthcare Products, Inc.Device for delivery of dermatological ingredients
US5962013 *4 Ago 19985 Oct 1999Cygnus, Inc.Monolithic matrix transdermal delivery system for administering molsidomine
US5980943 *21 Oct 19979 Nov 1999Alza CorporationSustained antiepileptic therapy
US6001390 *18 Dic 199614 Dic 1999Alza CorporationFormulations for transdermal delivery of pergolide
US6007837 *3 Feb 199928 Dic 1999Alza CorporationDrug delivery devices and process of manufacture
US6068853 *13 Oct 199530 May 2000Novartis CorporationTemporally controlled drug delivery systems
US6071896 *18 Mar 19986 Jun 2000Gundersen Clinic, Ltd.Suppression of thromboxane levels by percutaneous administration of aspirin
US6096333 *8 Oct 19971 Ago 2000Lectec CorporationMethod of forming adhesive patch for applying medication to the skin
US6096334 *14 Dic 19981 Ago 2000Lectec CorporationAdhesive patch for applying medication to the skin and method
US6110499 *20 Jul 199829 Ago 2000Alza CorporationPhenytoin therapy
US6126963 *6 Jun 19953 Oct 2000Lts Lohmann Therapie-Systeme Gmbh & Co. KgTransdermal therapeutic system, its use and production process
US6139868 *6 Jun 199531 Oct 2000Lts Lohmann Therapie-Systeme Gmbh & Co. KgTransdermal therapeutic system, its use and production process
US6165497 *1 Mar 199126 Dic 2000Alza CorporationSubsaturated nicotine transdermal therapeutic system
US61745453 Feb 199916 Ene 2001Alza CorporationDrug delivery devices and process of manufacture
US62038175 Jun 199820 Mar 2001Alza CorporationReduction of skin reactions caused by transdermal drug delivery
US62387005 May 199829 May 2001Alza CorporationMethod for preventing crystal formation in a dispersion of a liquid in a matrix
US626497816 Dic 199224 Jul 2001Lts Lohmann Therapie-Systeme Gmbh & Co. KgTransdermal application system containing acetylsalicylic acid for antithrombotic therapy and cancer prophylaxis
US626498018 Dic 199524 Jul 2001Lts Lohmann Therapie-Systeme GmbhTransdermal resorption of active substances from supercooled masses of levulic acid
US628759828 May 199311 Sep 2001Alza CorporationMethod for providing sustained antiepileptic therapy
US634421121 Nov 20005 Feb 2002Lts Lohmann Therapie-Systeme GmbhTransdermal absorption of active substances from subcooled melts
US634821010 Nov 199919 Feb 2002Alza CorporationMethods for transdermal drug administration
US644045727 May 199327 Ago 2002Alza CorporationMethod of administering antidepressant dosage form
US646922712 May 200022 Oct 2002Lectec CorporationAntipruritic patch
US651201014 Jul 199728 Ene 2003Alza CorporationFormulations for the administration of fluoxetine
US656944817 Oct 199727 May 2003Alza CorporationMethod for preventing crystal formation in a dispersion of a liquid in a matrix
US65728797 Jun 19953 Jun 2003Alza CorporationFormulations for transdermal delivery of pergolide
US659289229 Ago 200015 Jul 2003Tepha, Inc.Flushable disposable polymeric products
US666029529 Sep 19989 Dic 2003Alza CorporationTransdermal drug delivery device package with improved drug stability
US669949723 Jul 19992 Mar 2004Alza CorporationFormulations for the transdermal administration of fenoldopam
US696035329 Sep 20031 Nov 2005Alza CorporationFormulations for the transdermal administration of fenoldopam
US701184422 Nov 200214 Mar 2006Alza CorporationFormulations for the administration of fluoxetine
US706385918 Sep 200220 Jun 2006Noven Pharmaceuticals, Inc.Barrier film lined backing layer composition and method for topical administration of active agents
US709442220 Ago 200322 Ago 2006Acrux Dds Pty Ltd.Topical delivery of antifungal agents
US71694098 Sep 200330 Ene 2007Alza CorporationMethod for preventing crystal formation in a dispersion of a liquid in a matrix
US735789130 Ene 200415 Abr 2008Monosol Rx, LlcProcess for making an ingestible film
US742529214 Feb 200216 Sep 2008Monosol Rx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US755392326 Oct 200730 Jun 2009Metabolix, Inc.Medical devices and applications of polyhydroxyalkanoate polymers
US762213618 Jun 200424 Nov 2009Alza CorporationTransparent transdermal nicotine delivery devices
US764182529 Jul 20055 Ene 2010Tepha, Inc.Method of making a polyhydroxyalkanoate filament
US766633728 May 200423 Feb 2010Monosol Rx, LlcPolyethylene oxide-based films and drug delivery systems made therefrom
US782458814 Abr 20082 Nov 2010Monosol Rx, LlcMethod of making self-supporting therapeutic active-containing film
US7833208 *29 Dic 200416 Nov 2010Kimberly-Clark Worldwide, Inc.Multilayer absorbent article
US788348718 Dic 20088 Feb 2011Shantha Totada RTransdermal local anesthetic patch with injection port
US791064114 Dic 200622 Mar 2011Monosol Rx, LlcPH modulated films for delivery of actives
US794368331 Oct 200717 May 2011Tepha, Inc.Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US797261820 Sep 20075 Jul 2011Monosol Rx, LlcEdible water-soluble film containing a foam reducing flavoring agent
US801715022 Abr 200813 Sep 2011Monosol Rx, LlcPolyethylene oxide-based films and drug delivery systems made therefrom
US801759816 May 200713 Sep 2011Knopp Neurosciences, Inc.Compositions of R(+) and S(−) pramipexole and methods of using the same
US802625410 Nov 200927 Sep 2011Purdue Pharma, L.P.Therapeutic agents useful for treating pain
US803427030 Abr 200411 Oct 2011Tepha, Inc.Polyhydroxyalkanoate medical textiles and fibers
US807591120 Ago 200713 Dic 2011Alza CorporationTransparent transdermal nicotine delivery devices
US808405915 Sep 200627 Dic 2011Alza CorporationAntidepressant dosage form
US808412511 Dic 200927 Dic 2011Tepha, Inc.Non-curling polyhydroxyalkanoate sutures
US815316227 Sep 200610 Abr 2012Tissuetech, Inc.Purified amniotic membrane compositions and methods of use
US818284027 Sep 200622 May 2012Tissue Tech, Inc.Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US818284127 Sep 200622 May 2012Tissue Tech, Inc.Amniotic membrane preparations and purified compositions and anti-inflammation methods
US818763927 Sep 200629 May 2012Tissue Tech, Inc.Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US82359299 Jul 20097 Ago 2012Griffin Santea BMethod of treating pruritis
US82362886 Ene 20127 Ago 2012Skinmedica, Inc.Melanin modification compositions and methods of use
US824166221 Dic 200614 Ago 2012Watson Laboratories, Inc.Unoccluded topical oxybutynin gel composition and methods for transdermal oxybutynin therapy
US827336126 Sep 200725 Sep 2012Infectious Disease Research InstituteVaccine composition containing synthetic adjuvant
US8317762 *10 Nov 200827 Nov 2012Nurman SalimSkin patch for absorbing toxins from the body
US832973427 Jul 200911 Dic 2012Afgin Pharma LlcTopical therapy for migraine
US834351220 Oct 20111 Ene 2013Infectious Disease Research InstituteTreatment of allergic conditions using a composition containing synthetic adjuvant
US83538887 Oct 201015 Ene 2013Kimberly-Clark Worldwide, Inc.Multilayer absorbent article
US836127227 Jun 200729 Ene 2013Ferring B.V.Polyurethane elastomers
US83612736 Sep 201229 Ene 2013Ferring B.V.Polyurethane elastomers
US83779795 Dic 200619 Feb 2013Taro Pharmaceuticals North America, Inc.Pharmaceutical formulation containing phenytoin sodium and magnesium stearate
US838314922 Sep 200626 Feb 2013Alza CorporationHigh enhancer-loading polyacrylate formulation for transdermal applications
US842012623 Abr 201216 Abr 2013Tissue Tech, Inc.Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US844023523 Abr 201214 May 2013Tissuetech, Inc.Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US84454745 Ago 201121 May 2013Knopp Neurosciences, Inc.Compositions of R(+) and S(−) pramipexole and methods of using the same
US845500923 Abr 20124 Jun 2013Tissuetech, Inc.Amniotic membrane preparations and purified compositions and anti-inflammation methods
US846070726 Mar 201211 Jun 2013Ferring B.V.Stabilised prostaglandin composition
US84607143 Abr 201211 Jun 2013Tissuetech, Inc.Purified amniotic membrane compositions and methods of use
US84758327 Ago 20092 Jul 2013Rb Pharmaceuticals LimitedSublingual and buccal film compositions
US849193428 Jul 200523 Jul 2013Ferring B.V.Stabilised prostaglandin composition
US851892614 Dic 200727 Ago 2013Knopp Neurosciences, Inc.Compositions and methods of using (R)-pramipexole
US851914814 Mar 200827 Ago 2013Knopp Neurosciences, Inc.Synthesis of chirally purified substituted benzothiazole diamines
US852425415 Oct 20073 Sep 2013Ferring B.V.Bioresorbable polymers
US852469514 Mar 20083 Sep 2013Knopp Neurosciences, Inc.Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
US855728113 Jul 201015 Oct 2013Ferring B.V.Water-swellable polymers
US8574205 *12 Mar 20085 Nov 2013Dbv TechnologiesDevice for the cutaneous application of substances
US859242429 Jun 200926 Nov 2013Afgin Pharma LlcTopical regional neuro-affective therapy
US860351410 Jul 200710 Dic 2013Monosol Rx, LlcUniform films for rapid dissolve dosage form incorporating taste-masking compositions
US860911430 Ago 201217 Dic 2013Infectious Diesease Research InstituteMethods of using a vaccine composition containing synthetic adjuvant
US861417917 Jul 200924 Dic 2013E-Therapeutics PlcAntibacterial combination therapy for the treatment of gram positive bacterial infections
US862879810 Ago 201214 Ene 2014Ferring B.V.Water-swellable polymers
US863280012 May 200621 Ene 2014Alza CorporationMultilayer drug delivery system with barrier against reservoir material flow
US865237829 Mar 201318 Feb 2014Monosol Rx LlcUniform films for rapid dissolve dosage form incorporating taste-masking compositions
US86636805 Dic 20114 Mar 2014Alza CorporationTransparent transdermal nicotine delivery devices
US866368713 May 20104 Mar 2014Monosol Rx, LlcFilm compositions for delivery of actives
US868543726 Mar 20091 Abr 2014Monosol Rx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US870948231 May 201329 Abr 2014Ferring B.V.Stabilised prostaglandin composition
US871571529 Oct 20096 May 2014Nal Pharmaceuticals Ltd.Dosage form for insertion into the mouth
US87220644 Jun 201013 May 2014Infectious Disease Research InstituteSynthetic glucopyranosyl lipid adjuvants
US875355511 Abr 201117 Jun 2014Tepha, Inc.Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US875865716 Jul 201324 Jun 2014Tepha, Inc.Process of making polyhydroxyalkanoate medical textiles
US875880825 Feb 201324 Jun 2014Alza CorporationMethod of making a high enhancer-loading polyacrylate formulation for transdermal applications
US87651678 Sep 20061 Jul 2014Monosol Rx, LlcUniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US877173618 Oct 20128 Jul 2014Nal Pharmaceuticals, Ltd.Dosage form for insertion into the mouth
US877831526 Feb 201315 Jul 2014Allergan, Inc.Melanin modification compositions and methods of use
US877838230 Abr 200415 Jul 2014Purdue Pharma L.P.Tamper resistant transdermal dosage form
US879068918 Nov 200529 Jul 2014Purdue Pharma L.P.Tamper resistant transdermal dosage form
US879641625 Oct 20115 Ago 2014Questcor Pharmaceuticals, IncACTH prophylactic treatment of renal disorders
US884090830 Ago 201223 Sep 2014Infectious Disease Research InstituteVaccine composition containing synthetic adjuvant
US888383013 Ene 201211 Nov 2014Afgin Pharma LLC.Topical therapy for the treatment of migraines, muscle sprains, muscle spasms, spasticity and related conditions
US890049723 Ago 20132 Dic 2014Monosol Rx, LlcProcess for making a film having a substantially uniform distribution of components
US890049823 Ago 20132 Dic 2014Monosol Rx, LlcProcess for manufacturing a resulting multi-layer pharmaceutical film
US890627723 Ago 20139 Dic 2014Monosol Rx, LlcProcess for manufacturing a resulting pharmaceutical film
US895704718 Abr 201417 Feb 2015Immune Design Corp.GLA monotherapy for use in cancer treatment
US895721624 Mar 201117 Feb 2015Amitech Therapeutic Solutions, Inc.Heterocyclic compounds useful for kinase inhibition
US896259317 Jul 201424 Feb 2015Immune Design Corp.GLA monotherapy for use in cancer treatment
US897481327 Jun 200710 Mar 2015Ferring B.V.Hydrophilic polyurethane compositions
US897482610 Jun 201110 Mar 2015Monosol Rx, LlcNanoparticle film delivery systems
US899937927 Feb 20147 Abr 2015Alza CorporationTransparent transdermal nicotine delivery devices
US90124807 Dic 201221 Abr 2015Afgin Pharma LlcTopical therapy for migraine
US904440426 Feb 20132 Jun 2015Allergan, Inc.Melanin modification compositions and methods of use
US90444206 Abr 20122 Jun 2015Immune Design Corp.Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
US905606122 Sep 200616 Jun 2015Alza CorporationTransdermal nicotine salt delivery system
US907274710 Mar 20147 Jul 2015Peritech Pharma Ltd.Topical compositions and methods of treatment of anorectal disorders
US910834023 Ago 201318 Ago 2015Monosol Rx, LlcProcess for manufacturing a resulting multi-layer pharmaceutical film
US911407316 May 201425 Ago 2015Nal Pharmaceuticals, Ltd.Dosage form for insertion into the mouth
US911407416 May 201425 Ago 2015Nal Pharmaceuticals, Ltd.Dosage form for insertion into the mouth
US911407519 Jun 201425 Ago 2015Nal Pharmaceuticals, Ltd.Dosage form for insertion into the mouth
US911977619 Jun 20141 Sep 2015Nal Pharmaceuticals, Ltd.Dosage form for insertion into the mouth
US91257198 Sep 20118 Sep 2015Tepha, Inc.Polyhydroxyalkanoate medical textiles and fibers
US916195412 Mar 201320 Oct 2015Tissuetech, Inc.Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US916195513 Mar 201320 Oct 2015Tissuetech, Inc.Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US916195613 Mar 201320 Oct 2015Tissuetech, Inc.Amniotic membrane preparations and purified compositions and anti-inflammation methods
US917506626 Abr 20103 Nov 2015Tissuetech, Inc.Compositions containing HC-HA complex and methods of use thereof
US919893913 Mar 20131 Dic 2015Tissuetech, Inc.Purified amniotic membrane compositions and methods of use
US920505923 Feb 20158 Dic 2015Alza CorporationTransparent transdermal nicotine delivery devices
US92050909 May 20148 Dic 2015Alza CorporationHigh enhancer-loading polyacrylate formulation for transdermal applications
US921215112 Feb 201515 Dic 2015Amitech Therapeutic Solutions, Inc.Heterocyclic compounds useful for kinase inhibition
US92604177 Feb 201116 Feb 2016Amitech Therapeutic Solutions, Inc.Therapeutic methods and compositions involving allosteric kinase inhibition
US926574914 Abr 201523 Feb 2016Patara Pharma, LLCMethods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US927305114 Sep 20121 Mar 2016Pharmacyclics LlcPyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
US933306613 May 201410 May 2016Tepha, Inc.Method of making a medical textile from polyhydroxyalkanoate fibers
US937126413 Ene 201421 Jun 2016Corsair Pharma, Inc.Treprostinil derivative compounds and methods of using same
US939319222 Abr 200919 Jul 2016Alza CorporationMethods and dosage forms for controlled delivery of paliperidone and risperidone
US944600418 May 201520 Sep 2016Alza CorporationTransdermal nicotine salt delivery system
US946319818 Abr 201411 Oct 2016Infectious Disease Research InstituteCompositions and methods for reducing or preventing metastasis
US946863013 Ago 201318 Oct 2016Knopp Biosciences LlcCompositions and methods for treating conditions related to increased eosinophils
US948074021 Mar 20141 Nov 2016Infectious Disease Research InstituteSynthetic glucopyranosyl lipid adjuvants
US948077028 Feb 20141 Nov 2016Covidien LpMethods for preparation of medical dressing containing antimicrobial agent
US950573716 Jul 201429 Nov 2016Corsair Pharma, Inc.Treprostinil derivative compounds and methods of using same
US951209621 Dic 20126 Dic 2016Knopp Biosciences, LLPSynthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US951211611 Oct 20136 Dic 2016Calcimedica, Inc.Compounds that modulate intracellular calcium
US952677027 Abr 201227 Dic 2016Tissuetech, Inc.Methods of modulating bone remodeling
US955082224 Jun 201424 Ene 2017Questcor Pharmaceuticals, Inc.ACTH prophylactic treatment of renal disorders
US955515510 Dic 201531 Ene 2017Tepha, Inc.Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US957929520 Jul 201528 Feb 2017Nal Pharmaceutical Group LimitedDosage form for insertion into the mouth
US96112637 Oct 20144 Abr 2017Calcimedica, Inc.Compounds that modulate intracellular calcium
US964284013 Ago 20149 May 2017Knopp Biosciences, LlcCompositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
US966231328 Feb 201430 May 2017Knopp Biosciences LlcCompositions and methods for treating amyotrophic lateral sclerosis in responders
US967573310 Nov 201613 Jun 2017Tissuetech, Inc.Methods of modulating bone remodeling
US96820448 Jun 201220 Jun 2017Tissuetech, Inc.Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
US968206819 May 201420 Jun 2017Mylan Inc.Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
US96874546 Ene 201627 Jun 2017Indivior Uk LimitedSublingual and buccal film compositions
US970052216 Dic 201411 Jul 2017Vita Sciences LlcTransdermal patch and method for delivery of vitamin B12
US970161610 Jun 201611 Jul 2017Corsair Pharma, Inc.Treprostinil derivatives and compositions and uses thereof
US97072069 Ago 201618 Jul 2017Patara Pharma, LLCMast cell stabilizers treatment for systemic disorders
US97243708 Sep 20158 Ago 2017Tissuetech, Inc.Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US97507718 Sep 20155 Sep 2017Tissuetech, Inc.Amniotic membrane preparations and purified compositions and anti-inflammation methods
US97507729 Oct 20155 Sep 2017Tissuetech, Inc.Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US975853323 Abr 201512 Sep 2017The Research Foundation For The State University Of New YorkRapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjunction therewith
US976391813 Ago 201419 Sep 2017Knopp Biosciences LlcCompositions and methods for treating chronic urticaria
US977698218 May 20163 Oct 2017Corsair Pharma, Inc.Treprostinil derivative compounds and methods of using same
US98084913 Jun 20157 Nov 2017Tissuetech, Inc.Compositions of morselized umbilical cord and/or amniotic membrane and methods of use thereof
US980855421 Jul 20147 Nov 2017Covidien LpSuper soft foams
US20010038856 *13 Jul 20018 Nov 2001Sonya MerrillHydromorphone therapy
US20030008852 *1 Dic 20009 Ene 2003Franke HanshermannTransdermal system containing acetylsalicylic acid for treatment of migraine
US20030107149 *14 Feb 200212 Jun 2003International Fluidics.Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20030224051 *28 May 20034 Dic 2003Fink Tracy A.Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
US20040010000 *25 Abr 200315 Ene 2004Ayer Atul D.Methods and dosage forms for controlled delivery of oxycodone
US20040081684 *20 Ago 200329 Abr 2004Monash UniversityTopical delivery of antifungal agents
US20040191301 *27 Mar 200330 Sep 2004Van Duren Albert PhilipTransdermal device having a phase change material
US20040191314 *2 Abr 200430 Sep 2004Frank JaoAntiepileptic dosage form and process for protecting antiepileptic drug
US20040209909 *9 Abr 200221 Oct 2004Su Il YumNovel formulations for transdermal delivery of pergolide
US20040234576 *30 Abr 200425 Nov 2004Tepha, Inc., State Of Incorporation DelawarePolyhydroxyalkanoate medical textiles and fibers
US20040234585 *18 Jun 200425 Nov 2004Gale Robert M.Transparent transdermal nicotine delivery devices
US20040258742 *20 Jul 200423 Dic 2004Van Osdol William WoodsonTransdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
US20050002997 *30 Abr 20046 Ene 2005Howard Stephen A.Tamper resistant transdermal dosage form
US20050025809 *8 Jul 20043 Feb 2005Tepha, Inc.Poly-4-hydroxybutyrate matrices for sustained drug delivery
US20050037055 *28 May 200417 Feb 2005Monosolrx Llc.Polyethylene oxide-based films and drug delivery systems made therefrom
US20050048104 *30 Jun 20033 Mar 2005Venkatraman Subramanian S.Transdermal drug delivery devices comprising a polyurethane drug reservoir
US20050065062 *24 Sep 200324 Mar 20053M Innovative Properties CompanyMethod of formulating a pharmaceutical composition
US20050142475 *30 Dic 200330 Jun 2005Moudry Ronald J.Dry toner comprising encapsulated pigment, methods and uses
US20050184427 *29 Mar 200525 Ago 2005Monosolrx, Llc.Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20050186277 *15 Mar 200525 Ago 2005Gale Robert M.Novel formulations for the administration of fluoxetine
US20050191340 *8 Feb 20051 Sep 2005Gruenenthal GmbhOpioid-receptor antagonists in transdermal systems having buprenorphine
US20050234024 *14 Abr 200420 Oct 2005Clarke David EMaterials and methods for the treatment of ulcerative colitis
US20060008432 *7 Jul 200412 Ene 2006Sebastiano ScarampiGilsonite derived pharmaceutical delivery compositions and methods: nail applications
US20060039958 *28 Sep 200523 Feb 2006Monosolrx, Llc.Multi-layer films having uniform content
US20060051391 *8 Sep 20059 Mar 2006Dvoskin Victor ODevice for the controlled administration of substances to be inserted in a body cavity
US20060058470 *29 Jul 200516 Mar 2006Tepha, Inc.Non-curling polyhydroxyalkanoate sutures
US20060142722 *29 Dic 200429 Jun 2006Kimberly-Clark Worldwide, Inc.Multilayer absorbent article
US20060147493 *22 Jul 20036 Jul 2006Yang Robert KPackaging and dispensing of rapid dissolve dosage form
US20060177513 *27 Ene 200610 Ago 2006Tepha, Inc.Embolization using poly-4-hydroxybutyrate particles
US20060217790 *12 Sep 200528 Sep 2006Ohshin Mlp Co., Ltd.Sheet-like face pack and kits for face packs
US20060257461 *12 May 200616 Nov 2006Jansen Rolf RMultilayer galantamine delivery system with barrier against reservoir material flow
US20060257462 *12 May 200616 Nov 2006Jansen Rolf RMultilayer drug delivery system with barrier against reservoir material flow
US20060287659 *20 Ago 200421 Dic 2006Tepha, Inc.Polyhydroxyalkanoate nerve regeneration devices
US20070009600 *15 Sep 200611 Ene 2007Edgren David EAntidepressant dosage form
US20070065463 *21 Jun 200422 Mar 2007Ronald Aung-DinTopical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
US20070069416 *22 Jun 200629 Mar 2007Monosolrx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20070071740 *27 Sep 200629 Mar 2007Bio-Tissue, Inc.Purified amniotic membrane compositions and methods of use
US20070071828 *27 Sep 200629 Mar 2007Bio-Tissue, Inc.Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US20070082038 *22 Sep 200612 Abr 2007Gale Robert MTransdermal nicotine salt delivery system
US20070098771 *22 Sep 20063 May 2007Jay AudettHigh enhancer-loading polyacrylate formulation for transdermal applications
US20070098772 *22 Sep 20063 May 2007Westcott Tyler DTransdermal norelgestromin delivery system
US20070122455 *8 Sep 200631 May 2007Monosolrx, Llc.Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20070134310 *22 Sep 200614 Jun 2007Nedberge Diane ETransdermal risperidone delivery system
US20070148195 *21 Dic 200628 Jun 2007Ebert Charles DCompositions and methods for transdermal oxybutynin therapy
US20070149731 *14 Dic 200628 Jun 2007Monosolrx, Llc.PH modulated films for delivery of actives
US20070154527 *5 Dic 20065 Jul 2007Monosoirx, LlcTopical film compositions for delivery of actives
US20070172515 *19 Ene 200726 Jul 2007Monosolrx, LlcFilm bandage for mucosal administration of actives
US20070179210 *31 Ene 20072 Ago 2007Tyco Healthcare Group LpSuper soft foams
US20070185180 *5 Dic 20069 Ago 2007Tamar BlumbergPharmaceutical formulation containing phenytoin sodium and magnesium stearate
US20070190157 *19 Ene 200716 Ago 2007Monosoirx, Llc.Film lined packaging and method of making same
US20070231401 *27 Sep 20064 Oct 2007Bio-Tissue, Inc.Amniotic membrane preparations and purified compositions and anti-inflammation methods
US20070237812 *9 Mar 200711 Oct 2007Tyco Healthcare GroupMulti-layer wound dressings
US20070259930 *10 Abr 20078 Nov 2007Knopp Neurosciences, Inc.Compositions and methods of using r(+) pramipexole
US20070278289 *31 May 20066 Dic 2007Toshiba Tec Kabushiki KaishaPayment adjusting apparatus and program therefor
US20070281003 *13 Feb 20076 Dic 2007Fuisz Richard CPolymer-Based Films and Drug Delivery Systems Made Therefrom
US20080014259 *16 May 200717 Ene 2008Knopp Neurosciences, Inc.Compositions of R(+) and S(-) Pramipexole and Methods of Using the Same
US20080031933 *20 Ago 20077 Feb 2008Alza CorporationTransparent transdermal nicotine delivery devices
US20080044454 *10 Jul 200721 Feb 2008Monosolrx LlcUniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20080051490 *9 Ago 200728 Feb 2008Williams Simon FMedical Devices and Applications of Polyhydroxyalkanoate Polymers
US20080075825 *20 Sep 200727 Mar 2008Fuisz Richard CEdible Water-Soluble Film Containing a Foam Reducing Flavoring Agent
US20080081071 *28 Sep 20073 Abr 2008Pradeep SanghviFilm Embedded Packaging and Method of Making Same
US20080090894 *3 Dic 200717 Abr 2008Ronald Aung-DinTransdermal migraine therapy
US20080095823 *26 Oct 200724 Abr 2008Metabolix, Inc.Medical Devices and Applications of Polyhydroxyalkanoate Polymers
US20080131466 *26 Sep 20075 Jun 2008Infectious Disease Research InstituteVaccine composition containing synthetic adjuvant
US20080132602 *31 Oct 20075 Jun 2008Tepha, Inc.Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20080160065 *12 Jul 20073 Jul 2008Janet Anne HallidayDrug delivery polymer with hydrochloride salt of clindamycin
US20080227985 *14 Mar 200818 Sep 2008Knopp Neurosciences, Inc.Synthesis of chirally purified substituted benzothiazoles
US20080260805 *14 Abr 200823 Oct 2008Monosol Rx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20080260809 *22 Abr 200823 Oct 2008Monosol Rx, LlcPolyethylene oxide-based films and drug delivery systems made therefrom
US20080299087 *27 Sep 20064 Dic 2008Bio-Tissue, Inc.Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US20090005443 *20 Jun 20081 Ene 2009Malcolm Philip YoungTreatment of Depression
US20090035357 *8 Ago 20085 Feb 2009Arizant Healthcare Inc.Method of drug delivery using a transdermal device having a phase change material
US20090042956 *14 Dic 200712 Feb 2009Knopp Neurosciences, Inc.Compositions and methods of using (r)-pramipexole
US20090054504 *14 Mar 200826 Feb 2009Knopp Neurosciences, Inc.Modified Release Formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and Methods of Using the Same
US20090098069 *12 Sep 200816 Abr 2009Drugtech CorporationTransdermal, alcohol-free, pharmaceutical compositions
US20090169602 *23 Nov 20062 Jul 2009Universität ZürichAllergy Treatment by Epicutaneous Allergen Administration
US20090181069 *26 Mar 200916 Jul 2009Monosol Rx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20090181078 *9 Ene 200916 Jul 2009Infectious Disease Research InstituteVaccine composition containing synthetic adjuvant
US20090209983 *10 Sep 200820 Ago 2009Tepha, Inc.Polyhydroxyalkanoate nerve regeneration devices
US20090286246 *7 May 200919 Nov 2009Wintherix LlcMethods for Identifying Compounds that Affect Expression of Cancer-Related Protein Isoforms
US20090291120 *27 Jun 200726 Nov 2009Jukka TuominenHydrophilic Polyurethane Compositions
US20090304776 *19 Dic 200810 Dic 2009Totada ShanthaTransmucosal delivery of therapeutic agents and methods of use thereof
US20090311311 *18 Dic 200817 Dic 2009Shantha Totada RTransdermal local anesthetic patch with injection port
US20090324692 *27 Jun 200731 Dic 2009Controlled Therapeutics (Scotland) LimitedPolyurethane Elastomers
US20100021526 *7 Oct 200928 Ene 2010Monosol Rx, LlcPh modulated films for delivery of actives
US20100028389 *1 Oct 20094 Feb 2010Sonya MerrillHydromorphone therapy
US20100055437 *27 Ago 20094 Mar 2010Tyco Healthcare Group LpAnti-microbial fibers and related articles and methods
US20100068708 *7 May 200918 Mar 2010Wintherix LlcMethods for Identifying Compounds that Modulate WNT Signaling in Cancer Cells
US20100069437 *10 Nov 200918 Mar 2010Purdue Pharma L.P.Therapeutic agents useful for treating pain
US20100093237 *11 Dic 200915 Abr 2010Tepha, Inc.Non-curling polyhydroxyalkanoate sutures
US20100112050 *29 Oct 20096 May 2010Je Phil RyooDosage Form For Insertion Into The Mouth
US20100121297 *10 Nov 200813 May 2010Kenrico LtdSkin patch for absorbing toxins from the body
US20100143270 *21 Feb 200810 Jun 2010University Of Louisville Research FoubdationTherapeutic cotinine compositions
US20100209484 *12 Feb 201019 Ago 2010Hoo-Kyun ChoiTransdermal Triptan Delivery System
US20100221313 *30 Nov 20092 Sep 2010Innovative Pharmaceuticals, LlcTransdermal reservoir patch
US20110008411 *9 Jul 200913 Ene 2011Griffin Santea BMethod of treating pruritis
US20110009460 *21 Jun 201013 Ene 2011Valentin GribkoffCompositions and methods for treating amyotrophic lateral sclerosis
US20110014274 *26 Jul 201020 Ene 2011Infectious Disease Research InstituteVaccine composition containing synthetic adjuvant
US20110020217 *10 Oct 200827 Ene 2011E-Therapeutics PlcTreatment of melanoma
US20110021596 *27 Jul 200927 Ene 2011Ronald Aung-DinTopical therapy for migraine
US20110022015 *7 Oct 201027 Ene 2011Kimberly-Clark Worldwide, Inc.Multilayer absorbent article
US20110022016 *7 Oct 201027 Ene 2011Kimberly-Clark Worldwide, Inc.Multilayer absorbent article
US20110033376 *4 Jul 200810 Feb 2011Malcolm Philip YoungTreatment of Melanoma
US20110033541 *7 Ago 200910 Feb 2011Monosol Rx, LlcSublingual and buccal film compositions
US20110033542 *7 Ago 200910 Feb 2011Monosol Rx, LlcSublingual and buccal film compositions
US20110039906 *18 Jul 200817 Feb 2011E-Therapeutics PlcAntibacterial combination therapy
US20110046578 *12 Mar 200824 Feb 2011Biry Jean-FrancoisDevice for the cutaneous application of substances
US20110070290 *26 Jul 201024 Mar 2011Infectious Disease Research InstituteVaccine composition containing synthetic adjuvant
US20110189475 *11 Abr 20114 Ago 2011Tepha, Inc.Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20110190356 *19 Ago 20094 Ago 2011Knopp Neurosciences Inc.Compositions and Methods of Using (R)- Pramipexole
US20110212173 *17 Jun 20091 Sep 2011e-Therapeutics PleControlled Release Treatment of Depression
US20120245538 *2 Dic 201027 Sep 2012Michael HorstmannTransdermal Therapeutic System for the Administration of Peptides
USRE32991 *25 Jul 198818 Jul 1989Thermedics, Inc.Drug dispensing wound dressing
USRE379343 Feb 200010 Dic 2002Lts Lohmann Therapie-Systeme AgTransdermal therapeutic system
USRE3958831 Oct 199024 Abr 2007Alza CorporationTransdermal drug delivery device
DE2647581A1 *21 Oct 197627 Abr 1978Henkel KgaaBlisterpackung
DE3500508A1 *9 Ene 198512 Sep 1985Nitto Electric Ind CoPraeparat zur perkutanen verabreichung von arzneimitteln und verfahren zu dessen herstellung
DE3939703A1 *1 Dic 19896 Jun 1991Boehringer Ingelheim KgVerbesserte transdermale applikation von pharmakologisch aktiven verbindungen
DE3939703C2 *1 Dic 19892 Jul 1998Boehringer Ingelheim KgVerbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen
DE4421433C1 *18 Jun 19948 Jun 1995Lohmann Therapie Syst LtsTransdermal therapeutic system for treatment of, e.g., hypertension
DE102013107024A14 Jul 201315 May 2014Golden Biotechnology CorporationMethoden und Zusammensetzungen zum Behandeln, Modifizieren und Handhaben von Knochenkrebsschmerz
DE102013107025A14 Jul 20133 Jul 2014Golden Biotechnology CorporationMethoden und zusammensetzungen zur behanldung von diabetis
DE102013202928A122 Feb 201329 Ago 2013Golden Biotechnology CorporationVerfahren und Zusammensetzungen zum Behandeln von Krebsmetastasierung
EP0065370A1 *29 Abr 198224 Nov 1982Smith and Nephew Associated Companies p.l.c.Sterile dressing and preparation thereof
EP0236266A1 *9 Feb 19879 Sep 1987Ciba-Geigy AgDermal and transdermal therapeutic system having a discontinuous-pattern adhesive layer and method of manufacturing thereof
EP0246385A1 *23 May 198625 Nov 1987New Mexico Tech Research FoundationTranscutaneous application of nicotine
EP0249343A1 *14 May 198716 Dic 1987Alza CorporationMoisture activation of transdermal drug delivery system
EP0249475A2 *11 Jun 198716 Dic 1987Alza CorporationDelayed percutaneous delivery
EP0249475A3 *11 Jun 198711 Oct 1989Alza CorporationDelayed percutaneous delivery
EP0250125A2 *3 Jun 198723 Dic 1987Smith & Nephew plcDrug delivery device, its preparation and use
EP0250125A3 *3 Jun 198719 Abr 1989Smith And Nephew Associated Companies P.L.C.Drug delivery device, its preparation and use
EP0259136A21 Sep 19879 Mar 1988Alza CorporationTransdermal delivery device having a rate controlling adhesive
EP0273004A2 *16 Nov 198729 Jun 1988Ciba-Geigy AgUser-activated therapeutical system
EP0273004A3 *16 Nov 198713 Jul 1988Ciba-Geigy AgUser-activated therapeutical system
EP0279977A2 *28 Sep 198731 Ago 1988Alza CorporationTransdermal administration of progesterone, estradiol esters and mixtures thereof
EP0279977A3 *28 Sep 198729 Mar 1989Alza CorporationTransdermal administration of progesterone, estradiol esters and mixtures thereof
EP0336543A1 *23 Feb 198911 Oct 1989John Mark TuckerOcclusive body for administering a physiologically active substance
EP0498468A1 *23 May 198612 Ago 1992New Mexico Tech Research FoundationDevice for transcutaneous application of nicotine
EP1674068A119 Feb 199728 Jun 2006Acrux DDS Pty LtdDermal penetration enhancers and drug delivery systems involving same
EP2014282A220 Jun 200814 Ene 2009E-Therapeutics plcTreatment of depression
EP2158903A214 Dic 19993 Mar 2010ALZA CorporationTransparent Transdermal Nicotine Delivery Devices
EP2201840A128 Dic 200630 Jun 2010Pharmacyclics, Inc.Inhibitors of Bruton's Tyrosine Kinase
EP2308480A222 Sep 200613 Abr 2011ALZA CorporationHigh Enhancer-Loading Polyacrylate Formulation for Transdermal Applications
EP2316437A112 May 20064 May 2011Alza CorporationMultilayer drug delivery system with barrier against reservoir material flow
EP2443929A128 Dic 200625 Abr 2012Pharmacyclics, Inc.Inhibitors of Bruton's Tyrosine Kinase
EP2486938A126 Sep 200715 Ago 2012Infectious Disease Research InstituteVaccine composition containing synthetic adjuvant
EP2508231A215 Nov 200710 Oct 2012E-Therapeutics PlcImidazoles for treating multi-drug resistant bacterial infections
EP2526771A128 Dic 200628 Nov 2012Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
EP2526933A228 Dic 200628 Nov 2012Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
EP2526934A228 Dic 200628 Nov 2012Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
EP2529621A128 Dic 20065 Dic 2012Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
EP2529622A128 Dic 20065 Dic 2012Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
EP2529733A118 Jul 20085 Dic 2012E-Therapeutics PlcAntibacterial combination therapy
EP2529737A118 Jul 20085 Dic 2012E-Therapeutics plcAntibacterial combination therapy
EP2530083A128 Dic 20065 Dic 2012Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
EP2532234A128 Dic 200612 Dic 2012Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
EP2532235A128 Dic 200612 Dic 2012Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
EP2650294A112 Oct 201016 Oct 2013Pharmacyclics, Inc.Inhibitors of Bruton's Tyrosine Kinase
EP2664337A127 Sep 200620 Nov 2013TissueTech, Inc.Amniotic membrane preparations and purified compositions and methods of use
EP3078374A117 Oct 201212 Oct 2016Vanderbilt UniversityIndomethacin analogs for the treatment of castrate-resistant prostate cancer
WO1986000532A1 *7 Jul 198430 Ene 1986Flexcon Company, Inc.Silicone pressure sensitive adhesive and uses
WO1987003477A1 *12 Dic 198518 Jun 1987Flexcon Company, Inc.Transdermal methods and adhesives
WO1989007959A1 *23 Feb 19898 Sep 1989John Mark TuckerOcclusive body for administering a physiologically active substance
WO1991006270A1 *31 Oct 198916 May 1991Watson Laboratories, Inc.Mucoadhesive buccal dosage forms
WO1993012799A1 *16 Dic 19928 Jul 1993Lts Lohmann Therapie-Systeme Gmbh & Co. KgTransdermally administered system containing acetylsalicylic acid for thrombosis therapy and cancer prophylaxis
WO1994018966A1 *5 Feb 19941 Sep 1994Lts Lohmann Therapie-Systeme Gmbh & Co. KgTransdermal therapeutic system with active substances which represent sources of nitrogen oxide
WO1995035105A1 *3 Jun 199528 Dic 1995Lts Lohmann Therapie-Systeme Gmbh & Co. KgTransdermal therapeutic system with active substances constituting sources of carbon monoxide
WO2004105854A1 *3 Jun 20049 Dic 2004Nadler, JosephDevice and method for dispensing medication to tissue lining a body cavity
WO2007035939A222 Sep 200629 Mar 2007Alza CorporationHigh enhancer-loading polyacrylate formulation for transdermal applications
WO2007062266A228 Nov 200631 May 2007Marinus PharmaceuticalsGanaxolone formulations and methods for the making and use thereof
WO2008021368A213 Ago 200721 Feb 2008The Johns Hopkins UniversityCompositions and methods for neuroprotection
WO2008039218A228 Dic 20063 Abr 2008Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
WO2008066899A228 Nov 20075 Jun 2008Marinus PharmaceuticalsNanoparticulate formulations and methods for the making and use thereof
WO2009013480A218 Jul 200829 Ene 2009E-Therapeutics PlcAntibacterial combination therapy
WO2010005507A129 Jun 200914 Ene 2010Afgin Pharma, LlcTopical regional neuro-affective therapy
WO2010071866A219 Dic 200924 Jun 2010Nuon Therapeutics, Inc.Combination therapy for arthritis with tranilast
WO2010141861A14 Jun 20109 Dic 2010Infectious Disease Research InstituteSynthetic glucopyranosyl lipid adjuvants
WO2011030106A110 Sep 201017 Mar 2011E-Therapeutics PlcCancer cell apoptosis
WO2011119894A224 Mar 201129 Sep 2011Kinagen, IncHeterocyclic compounds useful for kinase inhibition
WO2011130689A115 Abr 201120 Oct 2011Tracon Pharmaceuticals, Inc.Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
WO2011139489A211 Abr 201110 Nov 2011Calcimedica Inc.Compounds that modulate intracellular calcium
WO2012046006A27 Oct 201112 Abr 2012University Of DundeeCancer targets
WO2012104589A12 Feb 20129 Ago 2012University Of EdinburghWeight related disorders
WO2013160645A126 Abr 201331 Oct 2013E-Therapeutics PlcDexanabinol or a derivative thereof for use in the treatment of cancer in dose ranges of 2-30 mg/kg
WO2013164561A13 May 20137 Nov 2013E-Therapeutics PlcTramadol for treating depression
WO2014110491A113 Ene 201417 Jul 2014Theratrophix LlcProdrugs of treprostinil
WO2014130619A220 Feb 201428 Ago 2014Golden Biotechnology CorporationMethods and compositions for treating leukemia
WO2014172637A118 Abr 201423 Oct 2014Immune Design Corp.Gla monotherapy for use in cancer treatment
WO2015084998A13 Dic 201411 Jun 2015Pharmacyclics, Inc.Inhibitors of bruton's tyrosine kinase
WO2015112485A120 Ene 201530 Jul 2015Immune Design Corp.Compositions for use in the treatment of allergic conditions
WO2016010538A116 Jul 201421 Ene 2016Corsair Pharma, Inc.Treprostinil derivative compounds and methods of using same
WO2016205202A114 Jun 201622 Dic 2016Corsair Pharma, Inc.Treprostinil derivatives and compositions and uses thereof
WO2017011611A114 Jul 201619 Ene 2017Lipp Life Sciences LlcPharmaceutical administration system for the transdermal application of vardenafil
WO2017027402A15 Ago 201616 Feb 2017Patara Pharma, LLCMethods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
WO2017040617A131 Ago 20169 Mar 2017Pharmacyclics LlcBtk inhibitor combinations for treating multiple myeloma
WO2017068349A120 Oct 201627 Abr 2017E-Therapeutics PlcCannabinoid for use in immunotherapy
Clasificaciones
Clasificación internacionalA61L15/58, A61M31/00, A61L15/16, A61M37/00, A61F9/00, A61K9/70
Clasificación cooperativaA61F9/0017, A61M31/002, A61K9/7084, A61M37/00, A61L15/58
Clasificación europeaA61F9/00B2, A61M31/00D, A61M37/00, A61L15/58, A61K9/70E2D
Eventos legales
FechaCódigoEventoDescripción
23 Nov 1982B1Reexamination certificate first reexamination