|Número de publicación||US3604425 A|
|Tipo de publicación||Concesión|
|Fecha de publicación||14 Sep 1971|
|Fecha de presentación||11 Abr 1969|
|Fecha de prioridad||11 Abr 1969|
|Número de publicación||US 3604425 A, US 3604425A, US-A-3604425, US3604425 A, US3604425A|
|Inventores||Pierre L Le Roy|
|Cesionario original||New Research And Dev Lab Inc|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (7), Citada por (143), Clasificaciones (7)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
United States Patet  Inventor Pierre L. Le Roy Wilmington, Del.  Appl. No. 815,395  Filed Apr. 11,1969  Patented Sept. 14, 1971  Assignee New Research and Development Laboratories, Inc. Continuation-impart of application Ser. No. 473,055, July 19, 1965, now Patent No. 3,446,212.
 HEMOSTATIC CLIP 6 Claims, 17 Drawing Figs.
 U.S.Cl 128/325, 24/255, 128/346 [51} Int. Cl A611) 17/08, A61b 17/12  Field of Search 128/325, 334, 335, 337, 346; 24/255  References Cited UNITED STATES PATENTS 992,995 5/1911 Staples 24/255 U 3,326,217 6/1967 Kerr 128/325 3,446,212 5/1969 Le Roy. 128/325 3,509,882 5/1970 Blake 128/325 FOREIGN PATENTS 865,475 21194] France 24/3().5
1,058,094 2/1967 Great Britain.. 24/255.l
464,802 7/1951 Italy 128/337 Primary Examiner-Dalton L. Truluck AttorneyConnolly and Hutz Pmeminswmsn 3.604.425
SHEET 2 [IF 2 I'IEMOSTATIC CLIP CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation-in-part of copending application Ser. No. 473,055, filed July 19, 1965, now US Pat. No. 3,446,212 issued May 27,1969.
BACKGROUND OF INVENTION This invention relates to hemostatic clips for use in clamping wound flaps to prevent the flow of blood from severed arteries, capillaries and the like.
Applicants patent previously referred to describes and claims a highly successful hemostatic clip which is inexpensive, easily sterilized so that it can be prepackaged, disposable, adapted to be made in a variety of dimensions and can be easily applied and removed by a relatively unskilled worker. The clip disclosed in that application is essentially a tubular member having a slit completely across its body so that it can be distended from its original shape to receive the wound flap therein. As particularly disclosed in the parent application the tubular body can be distended from its original shape because of the provision of a pair of parallel slots which are disposed about 90 from the longitudinal slit whereby a plierslike applicating tool can be inserted into the slots and upon application of force thereto the longitudinal slit will be spread apart to receive the wound flap.
SUMMARY OF INVENTION An object of this invention is to provide a modified form of the above-type clip which still retains all of its advantages.
In accordance with this invention a pair of projections are disposed on the body instead of the parallel slots. The projections are connected to the body along longitudinal lines which are similarly disposed about 90 from the wound flap receiving slit. When force is applied to the projections they act as levers to spread the longitudinal slit and facilitate the insertion of the wound flap therein.
Advantageously, each projection includes a stem portion connected to the clip body and an enlarged head portion on the stem. The body may be horseshoe shaped to accommodate a greater portion of the wound flap. Furthermore the body may terminate in flanges which are perpendicular to the leg sections of the horseshoe and which have parallel undulations to provide greater traction of the wound flap while minimizing tissue damage and pain.
In another form of this invention the body is provided with a plurality of parallel peripheral slots which terminate adjacent the wound flap receiving slit whereby a longitudinal margin is formed on each side of the slit to provide stability and to control flexibility of the body. Such a clip has the advantages of greater visibility, ventilation and drainage of the wound flap and can be utilized for clamping relatively long wound flaps.
THE DRAWINGS FIG. 1 is a side view in elevation and partly in section showing a clip applied to a wound flap in accordance with one aspect of this invention;
FIG. 2 is a top plan view of the clip shown in FIG. 1;
FIG. 3 is a side view of the clip shown in FIGS. 1-2;
FIG. 4 is a bottom plan view of the clip shown in FIGS. 1-3;
FIG. 5 is an enlarged view taken through FIG. 4 along the line 5-5 and showing the clip clamping against a wound flap;
FIG. 6 is a side view of an applicator in accordance with another embodiment of this invention;
FIG. 7 is a front view ofthe applicator shown in FIG. 6;
F IG. 8 is a cross-sectional view taken through FIG. 6 along the line 88;
FIG. 9 is a plan view of a portion of the applicator shown in FIGS. 6-8;
FIGS. IO-II are side views of the applicator and its clip in different phases of operation;
FIG. 12 is a cross-sectional view taken through FIG. 11 along the line l2-l2;
FIGS. 13-15 are front, top and side views, respectively, of the clip shown in FIGS. 10-12; and
FIGS. 16-17 are side views of modified clips in accordance with this invention.
DETAILED DESCRIPTION FIGS. l-5 show a clip in accordance with one embodiment of this invention. As indicated therein clip 10 is generally of tubular form in that it is in the shape of a hollow body open at both ends. The clip can be constructed from any material possessing the required elastic modulus and physical properties. Nylon tubing for example as well as Delrin, Teflon polyethylene, polypropylene and other suitable polymers and/or plastics are particularly adapted for this invention. Additionally, thin metal tubes or other alloys are also suitable. The tubular body can be formed into a circular, rectangular, triangular, square, elliptical or other adaptable cross section having the appropriate physical properties and being clinically acceptable. As illustrated in the drawings, however, the tubular body is advantageously of generally horseshoe shape to increase its wound-flap-receiving capability.
Clip 10 may be of any desired length required by the specific purpose to which it is to be used. Some advantageous lengths for example are one-fourth, one-half, and l inch, with the longer length being suitable for large wound flaps.
Clip 10 includes a longitudinal slit 12 across its entire length so that it can be distended by for example any suitable applicator 14. Upon being distended the slit 12 is spread apart whereby the wound flap 16 can easily be inserted therein. Upon release of force from the applicator the slit edges are then applied to the two sides of wound flap 16 or other tissue to prevent the flow of blood from severed arteries, capillaries or the like. At approximately to the longitudinal slit 12 are two parallel projections 18, 18 which are longitudinally centered on the clip body. Each projection includes a stem portion 20 which, as best shown in FIG. 5, is integral with the clip body and is tangential thereto. Stem 20 actually forms an extension of the leg sections 24 of the horseshoe-shaped clip body. Stem 20 terminates in an enlarged arcuate head 22 to facilitate the reception of applicator tool 14 thereon. Projections 18 extend at least one-third of the length of the clip body to provide a sufficient area for the reception of applicator 14.
As best shown in FIG. 5 the clip body is horseshoe shaped having an arcuate bridging section 26 between projections 18 with the straight leg sections 24 connected to the bridging section. Leg sections 24 terminate in substantially perpendicular flanges 28 which are spaced from each other to form the slit 12. The flanges 28, as shown in FIG. 4, terminate in parallel undulations 30 disposed generally parallel to the longitudinal axis of the clip body with the sinusoidal teeth being generally parallel and having gently merging hills and valleys. As shown in FIG. 5 the undulations taper in a converging direction toward the slit with the inner surfaces 32 of the flanges 28 being coplanar and with the flanges terminating in blunt or rounded ends 34. This particular configuration of slit 12 is particularly effective in providing sufficient traction to the wound flap while minimizing any pain thereto or undue damage to the tissue.
Clip 10 can be easily and rapidly removed either with applicator 14 or by hand. Manual removal is accomplished by squeezing projections 18 toward each other so that the projections act as levers to spread flanges 28 away from each other. The clip 10 can then be merely slipped off the wound flap 16 without noticeable damage to the tissue. Additionally, no special training is necessary for the scrub nurse, assistant, or surgeon in applying or removing clips 10.
Other advantages of clip 10 are that it can be sterilized by either the flash or routine method employing high pressure and high temperature. Clip 10 can also be sufficiently inexpensive to be disposable and thus packaged in presterile units.
When desired or necessary, however, clips can be reused. Even if the clips are unduly abused by, for example, being dropped, the clips show no structural fatigue or cracks and maintain their elastic state to a high degree.
correspondingly, the operative maintenance of applicator 14 is minimal. Applicator 14 may for example be made of a metal which can be autoclaved and handled without any unusual difficulty.
Advantageously, clip 10 may incorporate an X-ray or radiopaque material such as barium sulfate. Accordingly, the clip can be easily located if it should be lost within the operative site. Additionally, a bacteriostatic material may be used for clip 10. Accordingly, items such as iodonated compounds and an alpha or a low energy beta emitter may be added.
As indicated above clip 10 has proven to be exceptionally effective. For example, its ease of application, the lack of tissue irritability, the ease of adjustment, and the rapid removal enable the surgeon to move more quickly on entering the operative field. Clip 10 is particularly effective with scalp and back wounds, and can also be advantageously used on abdominal or long flap wounds as may be necessary in extremity work. Moreover, the gentleness with which the blood vessels are compressed and the lack of tissue irritability are especially notable.
FIGS. 6l7 illustrate another clip 40 formed in accordance with this invention. Clip 40 is for example made of a disposable plastic material or materials previously enumerated with respect to clip 10. Clip 40 is of extended or continuous length, being at least 10 inches long, so that it can be cut to the desired size for individual application. Additionally, clip 40 is specifically designed to provide maximum ventilation and drainage of the wound as well as increased visibility thereof.
As indicated most clearly in FIGS. 1345, clip 40 is of tubular form having a suitable wall thickness and a continuous elongated longitudinal slit 42. Clip 40 may be of any length such as the medium-size clip as indicated in FIGS. 14-15 or the extra-long clip shown in FIG. 16. The border or margin on each side of slit 42 forms a pair of elongated longitudinal backbones 44 and 46. Additionally, clip 40 includes a plurality of parallel-spaced peripheral slots 48 which are separated by ribs 50 spanning backbones 44 and 46. The provision of these perforations or slots 48 not only provides visibility, ventilation, and drainage of the wound flap 52 (FIG. 11), but also permits the delicate adjustment of a balance between the clamping strength and ease of application of clip 40. The thickness of backbones 44 and 46 determines the flexibility of clip 40 and its ability to conform to any wound configurations. Thus clip 40 can be applied in a bent or curved manner, as well as in a relatively straight line.
Although slots 48 are an exceptionally effective manner of forming perforations in clip 40 it is also possible to form the perforations in other ways, as long as the perforations permit flexibility, adequate clamping force, and visibility of the wound.
One modification of clip 40 is shown in FIG. 17 in which backbones 44 and 46 are serrated along slit 42 to provide more positive traction on the wound flap.
FIGS. 6-12 illustrate the applicator 60 which is particularly adapted for clips 40. As indicated therein, applicator 60 is made of two parts. One part 62 is a relatively long support rod, one end of which may be conveniently held and used as a handle as shown in FIG. 15. The second member or part is guide rod 64. Guide rod 64 includes a feed end 66 and a discharge end 68. Discharge end 68 is secured to the remote end 70 of support rod 62 to form the dispensing end 76 of applicator 60. Members 62 and 64 are made, for example, in the form of flattened tubular elements as best shown in FIG. 16. Accordingly, a pair of grooves 72 and 74 are formed at the juncture of discharge end 68 and remote end 70. As shown in FIGS. 7 and 9 dispensing end 76 of applicator 60 tapers or widens outwardly. Thus the distance between grooves 72 and 74 also increases.
In use the tubular clip 40 is inserted around feed end 66 of guide member 64 as shown in FIG. 10. Since feed end 66 is spaced from support rod 62, clip 40 can easily be loaded around guide rod 64. Applicator 60 is then brought into the vicinity of wound flap 52. Advantageously, dispensing end 76 of applicator 60 is concave and tapered to act as a registry means for wound flap 52 so that wound flap can be inserted in the concave portion 78 and maintained in position for the application of clip 40 as most clearly shown in FIG. 15. Additionally, this registry is facilitated by the tapered end of applicator 60 in which guide member 64 projects slightly beyond support member 62.
After wound flap 52 has been brought into registry in tapered concave portion 78 clip 40 is slid down guide member 64. The end of clip 40 is open or distended by the outwardly tapering dispensing end 76 of applicator 60. Accordingly, clip 40 is simply progressively slid off applicator 60 in an open position onto flap 52.
Applicator 60 which is made of a clinically acceptable material such as steel or other metal or plastic, and can easily be held in either hand with the clip 40 being advanced by the thumb of the other hand. When the required length of clip 40 has been applied to wound flap 52, the excess clip can be cut off by, for example, a scissors. Clip 40 can thereby be easily applied in a simple sweeping fashion. Thus for example for the first time a large area can be clamped by employing two large continuous hemostatic clips 40 by using only two maneuvers, in contrast to the multiple repeated maneuvers which have been required with conventional small clamps. In addition to the above noted advantages of ease of application and removal of clip 40, the clip also renders the operative area free of clutter.
For removal, clip 40 can be fractionally withdrawn from wound flap 52 to allow for surgical closure by interrupted sutures for controlling hemostasis and approximation of tissue planes. This can be done manually, without requiring an instrument, as is ordinarily necessary for conventional clips. Alternatively, the clip 40 can be removed in one sweeping motion, if necessary, rather than fractionally or with the conventional multiple actions.
1. A hemostatic clip comprising a body in the form of an elongated tubular element, said tubular element having an ellipsoidal cross section, wound-flap-engaging means on said body, said wound-flap-engaging means being an elongated longitudinal slit extended completely across said body whereby said body may be distended from its original shape, a pair of outwardly extending projections connected to said body remote from said slit for accommodating a force-applying tool, said body being resiliently urged to maintain its original tubular shape whereby the original tubular shape of said body may be distended upon application of force to said projections to cause said slit to widen and permit the insertion of a wound flap therein and said body will return toward its original undistended tubular shape upon cessation of the application of force for firmly engaging the wound flap, said slit being defined by a pair of longitudinal edges, and said edges being shaped as sinusoidal teeth having gently merging hills and valleys and wherein said teeth taper outwardly away from said edges, said teeth being defined in cross section by an inner wall disposed toward the interior of said tubular body, said inner walls of said teeth being generally aligned, and each outer wall being inclined from its edge where it merges with its inner wall outwardly away from its inner wall.
2. A clip as set forth in claim 1 wherein said body is made of a polymer material.
3. A clip as set forth in claim 2 wherein the sinusoidal curvatures of said teeth are generally parallel.
4. A clip as set forth in claim 3 wherein each of said projections is joined to said body along a longitudinal line disposed about from said longitudinal slit, each of said projections comprising a stem portion connected to said body and a head portion connected to said stern portion, said stern portion and body may be distended from its original shape, a plurality of parallel peripheral slots being in said body and terminating adjacent said longitudinal slit with a longitudinal margin on each side of said slit forming a thin backbone to provide stability and to control the flexibility of said body, and said body being at least 10 inches long and being axially bendable for clamping a relatively long wound flap.
6 A clip as set forth in claim 5 wherein the edges of said slit are serrated to provide positive traction on the wound flap.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US992995 *||23 Sep 1910||23 May 1911||Augustine E Staples||Cow-tail holder.|
|US3326217 *||27 Abr 1964||20 Jun 1967||Sydney Kerr Harry||Hemostatic clamp|
|US3446212 *||19 Jul 1965||27 May 1969||New Research & Dev Lab Inc||Hemostatic clip and applicator therefor|
|US3509882 *||18 Sep 1967||5 May 1970||American Hospital Supply Corp||Parallel jaw spring clip and applicator|
|FR865475A *||Título no disponible|
|GB1058094A *||Título no disponible|
|IT464802A *||Título no disponible|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3863301 *||29 Dic 1972||4 Feb 1975||Leveen Harry H||Elastic bandage and fastener therefor|
|US4177818 *||5 Dic 1977||11 Dic 1979||Pedro Francisco L De||Self attachable small-toothed electrode and a forceps for maneuvering it|
|US4217902 *||14 Nov 1978||19 Ago 1980||March Alfred L||Hemostatic clip|
|US4317451 *||19 Feb 1980||2 Mar 1982||Ethicon, Inc.||Plastic surgical staple|
|US4340061 *||25 Oct 1977||20 Jul 1982||Mayfield Education And Research Fund||Aneurysm clip|
|US4416266 *||15 May 1981||22 Nov 1983||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Medical clip|
|US4447943 *||10 Feb 1983||15 May 1984||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Process of making medical clip|
|US4465071 *||22 Sep 1982||14 Ago 1984||Samuels Peter B||Method of applying skin clips|
|US4490326 *||6 Oct 1982||25 Dic 1984||Ethicon, Inc.||Molding process for polydioxanone polymers|
|US4506669 *||22 Sep 1982||26 Mar 1985||Blake Joseph W Iii||Skin approximator|
|US4586503 *||1 Dic 1983||6 May 1986||University Of New Mexico||Surgical microclip|
|US4612932 *||2 Oct 1984||23 Sep 1986||Aesculap-Werke Ag Vormals Jetter & Scheerer||Magazine for C-shaped scalp clips|
|US4637395 *||2 Oct 1984||20 Ene 1987||Aesculap-Werke Ag||Applicator for C-shaped scalp clips|
|US4733664 *||15 Oct 1985||29 Mar 1988||University Of New Mexico||Surgical clip, applier, and method|
|US4796627 *||26 Ago 1986||10 Ene 1989||Tucker Wilson H||Clip applicator and spreadable clips for use therein|
|US4835824 *||13 Abr 1988||6 Jun 1989||Durham Vaughn L||Medical clamp|
|US4929239 *||5 Feb 1988||29 May 1990||Aesculap-Werke Ag Vormals Jetter & Scheerer||Device for filling the magazine of a scalp clip applicator with C-shaped scalp clips|
|US5147306 *||1 Jul 1991||15 Sep 1992||Gubich Stephen J||Device for puckering the flesh to facilitate injections|
|US5207692 *||30 Jul 1990||4 May 1993||Codman & Shurtleff, Inc.||Surgical clip applier with reciprocating clip sleeve and dual ratchet mechanism|
|US5366458 *||13 Dic 1990||22 Nov 1994||United States Surgical Corporation||Latchless surgical clip|
|US5474732 *||28 Jul 1994||12 Dic 1995||United States Surgical Corporation||Forming latchless surgical clip and fixture for use therein|
|US5640742 *||27 Dic 1995||24 Jun 1997||Temtec, Inc.||Spring badge clip|
|US5665097 *||21 Abr 1995||9 Sep 1997||Baker; John W.||Clip applicator|
|US5695505 *||9 Mar 1995||9 Dic 1997||Yoon; Inbae||Multifunctional spring clips and cartridges and applicators therefor|
|US5725542 *||27 Feb 1997||10 Mar 1998||Yoon; Inbae||Multifunctional spring clips and cartridges and applicators therefor|
|US5782844 *||5 Mar 1996||21 Jul 1998||Inbae Yoon||Suture spring device applicator|
|US5810851 *||5 Mar 1996||22 Sep 1998||Yoon; Inbae||Suture spring device|
|US5810853 *||16 Ene 1996||22 Sep 1998||Yoon; Inbae||Knotting element for use in suturing anatomical tissue and methods therefor|
|US5827306 *||13 Jun 1997||27 Oct 1998||Yoon; Inbae||Multifunctional spring clips and cartridges and applicators therefor|
|US5849019 *||7 Oct 1997||15 Dic 1998||Yoon; Inbae||Multifunctional spring clips and cartridges and applications therefor|
|US5972001 *||23 Ene 1998||26 Oct 1999||Yoon; Inbae||Method of ligating anatomical tissue with a suture spring device|
|US6197042||5 Ene 2000||6 Mar 2001||Medical Technology Group, Inc.||Vascular sheath with puncture site closure apparatus and methods of use|
|US6241740||9 Abr 1998||5 Jun 2001||Origin Medsystems, Inc.||System and method of use for ligating and cutting tissue|
|US6277140||16 Ene 2001||21 Ago 2001||Integrated Vascular Systems, Inc.||Vascular sheath with puncture site closure apparatus and methods of use|
|US6349727||25 May 2000||26 Feb 2002||Pos-T-Vac, Inc.||Penile clamp for inhibiting incontinence|
|US6391048||5 Jul 2000||21 May 2002||Integrated Vascular Systems, Inc.||Integrated vascular device with puncture site closure component and sealant and methods of use|
|US6461364||11 Abr 2000||8 Oct 2002||Integrated Vascular Systems, Inc.||Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
|US6527786||21 Jun 1999||4 Mar 2003||Origin Medsystems, Inc.||System and method of use for ligating and cutting tissue|
|US6632238||20 Ago 2001||14 Oct 2003||Integrated Vascular Systems, Inc.||Vascular sheath with puncture site closure apparatus and methods of use|
|US6695867||21 Feb 2002||24 Feb 2004||Integrated Vascular Systems, Inc.||Plunger apparatus and methods for delivering a closure device|
|US6719777||7 Dic 2000||13 Abr 2004||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US6749621||21 Feb 2002||15 Jun 2004||Integrated Vascular Systems, Inc.||Sheath apparatus and methods for delivering a closure device|
|US6780197||7 Dic 2000||24 Ago 2004||Integrated Vascular Systems, Inc.||Apparatus and methods for delivering a vascular closure device to a body lumen|
|US6942674||21 Feb 2002||13 Sep 2005||Integrated Vascular Systems, Inc.||Apparatus and methods for delivering a closure device|
|US7712190 *||18 Feb 2004||11 May 2010||Peter Weingartner||Clip for clipping sheets together|
|US7806904||24 Feb 2004||5 Oct 2010||Integrated Vascular Systems, Inc.||Closure device|
|US7806910||31 Jul 2006||5 Oct 2010||Abbott Laboratories||Multi-element biased suture clip|
|US7819895||18 Abr 2006||26 Oct 2010||Integrated Vascular Systems, Inc.||Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
|US7828817||4 Ago 2005||9 Nov 2010||Integrated Vascular Systems, Inc.||Apparatus and methods for delivering a closure device|
|US7841502||18 Dic 2007||30 Nov 2010||Abbott Laboratories||Modular clip applier|
|US7842068||30 Nov 2001||30 Nov 2010||Integrated Vascular Systems, Inc.||Apparatus and methods for providing tactile feedback while delivering a closure device|
|US7850709||4 Jun 2003||14 Dic 2010||Abbott Vascular Inc.||Blood vessel closure clip and delivery device|
|US7850797||12 Mar 2009||14 Dic 2010||Integrated Vascular Systems, Inc.||Methods for manufacturing a clip and clip|
|US7854810||17 Dic 2003||21 Dic 2010||Integrated Vascular Systems, Inc.||Methods for manufacturing a clip and clip|
|US7857828||1 Feb 2005||28 Dic 2010||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US7867249||8 Ago 2003||11 Ene 2011||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US7879071||9 May 2003||1 Feb 2011||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US7887553||8 Jul 2002||15 Feb 2011||Tyco Healthcare Group Lp||Right angle clip applier apparatus and method|
|US7887555||9 Jul 2003||15 Feb 2011||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US7887563||14 Jun 2005||15 Feb 2011||Abbott Vascular Inc.||Surgical staple|
|US7896895 *||23 Nov 2005||1 Mar 2011||Ethicon Endo-Surgery, Inc.||Surgical clip and applier device and method of use|
|US7896896||22 Abr 2003||1 Mar 2011||Tyco Healthcare Group Lp||Endoscopic surgical clip|
|US7901428||3 Oct 2002||8 Mar 2011||Integrated Vascular Systems, Inc.||Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
|US7905900||30 Ene 2003||15 Mar 2011||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US7918873||18 Sep 2006||5 Abr 2011||Abbott Vascular Inc.||Surgical staple|
|US7931669||17 May 2002||26 Abr 2011||Integrated Vascular Systems, Inc.||Integrated vascular device with puncture site closure component and sealant and methods of use|
|US8048108||4 Feb 2009||1 Nov 2011||Abbott Vascular Inc.||Vascular closure methods and apparatuses|
|US8128644||19 Sep 2003||6 Mar 2012||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8182497||4 Oct 2010||22 May 2012||Integrated Vascular Systems, Inc.||Closure device|
|US8187290 *||28 Ene 2008||29 May 2012||Damage Control Surgical Technologies, Inc.||Method and apparatus for vascular and visceral clipping|
|US8192459||13 Dic 2010||5 Jun 2012||Abbott Vascular Inc.||Blood vessel closure clip and delivery device|
|US8202283||12 Nov 2010||19 Jun 2012||Integrated Vascular Systems, Inc.||Methods for manufacturing a clip and clip|
|US8202293||20 Jun 2008||19 Jun 2012||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US8202294||20 Dic 2010||19 Jun 2012||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US8226681||25 Jun 2007||24 Jul 2012||Abbott Laboratories||Methods, devices, and apparatus for managing access through tissue|
|US8236026||27 Mar 2006||7 Ago 2012||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8257390||15 Feb 2007||4 Sep 2012||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8303624||15 Mar 2010||6 Nov 2012||Abbott Cardiovascular Systems, Inc.||Bioabsorbable plug|
|US8313497||20 Nov 2012||Abbott Laboratories||Clip applier and methods of use|
|US8323312||9 Jun 2009||4 Dic 2012||Abbott Laboratories||Closure device|
|US8372095||3 Feb 2011||12 Feb 2013||Covidien Lp||Endoscopic surgical clip|
|US8398656||2 Mar 2011||19 Mar 2013||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US8398676||29 Oct 2009||19 Mar 2013||Abbott Vascular Inc.||Closure device|
|US8469995||4 Jun 2012||25 Jun 2013||Abbott Vascular Inc.||Blood vessel closure clip and delivery device|
|US8486092||11 Mar 2009||16 Jul 2013||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8486108||1 Feb 2006||16 Jul 2013||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8518057||13 Sep 2012||27 Ago 2013||Abbott Laboratories||Clip applier and methods of use|
|US8529587||6 Jun 2012||10 Sep 2013||Integrated Vascular Systems, Inc.||Methods of use of a clip applier|
|US8556930||28 Jun 2006||15 Oct 2013||Abbott Laboratories||Vessel closure device|
|US8556932||19 May 2011||15 Oct 2013||Abbott Cardiovascular Systems, Inc.||Collapsible plug for tissue closure|
|US8579932||24 Feb 2004||12 Nov 2013||Integrated Vascular Systems, Inc.||Sheath apparatus and methods for delivering a closure device|
|US8585836||18 Jun 2012||19 Nov 2013||Integrated Vascular Systems, Inc.||Methods for manufacturing a clip and clip|
|US8590760||24 May 2005||26 Nov 2013||Abbott Vascular Inc.||Surgical stapler|
|US8591530||9 Ene 2009||26 Nov 2013||Cook Medical Technologies Llc||Suture guide clip and laparoscopic techniques|
|US8597310||29 Nov 2010||3 Dic 2013||Cook Medical Technologies Llc||Laparoscopic anastomosis tools and technique|
|US8597325||29 Nov 2010||3 Dic 2013||Integrated Vascular Systems, Inc.||Apparatus and methods for providing tactile feedback while delivering a closure device|
|US8603116||4 Ago 2010||10 Dic 2013||Abbott Cardiovascular Systems, Inc.||Closure device with long tines|
|US8603136||3 May 2007||10 Dic 2013||Integrated Vascular Systems, Inc.||Apparatus and methods for providing tactile feedback while delivering a closure device|
|US8617184||15 Feb 2011||31 Dic 2013||Abbott Cardiovascular Systems, Inc.||Vessel closure system|
|US8623009 *||5 Abr 2006||7 Ene 2014||The Brigham And Women's Hospital, Inc.||Endoscopic gastric bypass defect repair|
|US8652151||13 Ene 2011||18 Feb 2014||Covidien Lp||Right angle clip applier apparatus and method|
|US8657852||8 Mar 2013||25 Feb 2014||Abbott Vascular Inc.||Closure device|
|US8672953||6 Jun 2011||18 Mar 2014||Abbott Laboratories||Tissue closure system and methods of use|
|US8690910||31 Mar 2006||8 Abr 2014||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8728119||18 Feb 2011||20 May 2014||Abbott Vascular Inc.||Surgical staple|
|US8758396||27 Abr 2006||24 Jun 2014||Integrated Vascular Systems, Inc.||Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
|US8758398||7 Sep 2007||24 Jun 2014||Integrated Vascular Systems, Inc.||Apparatus and method for delivering a closure element|
|US8758399||2 Ago 2010||24 Jun 2014||Abbott Cardiovascular Systems, Inc.||Expandable bioabsorbable plug apparatus and method|
|US8758400||8 Nov 2010||24 Jun 2014||Integrated Vascular Systems, Inc.||Closure system and methods of use|
|US8784447||25 Abr 2005||22 Jul 2014||Abbott Vascular Inc.||Surgical stapler|
|US8808310||14 Feb 2007||19 Ago 2014||Integrated Vascular Systems, Inc.||Resettable clip applier and reset tools|
|US8820602||19 Nov 2010||2 Sep 2014||Abbott Laboratories||Modular clip applier|
|US8821534||6 Dic 2010||2 Sep 2014||Integrated Vascular Systems, Inc.||Clip applier having improved hemostasis and methods of use|
|US8858594||18 Dic 2009||14 Oct 2014||Abbott Laboratories||Curved closure device|
|US8882786||17 Feb 2004||11 Nov 2014||Lawrence Livermore National Security, Llc.||System for closure of a physical anomaly|
|US8893947||17 Dic 2007||25 Nov 2014||Abbott Laboratories||Clip applier and methods of use|
|US8905937||26 Feb 2009||9 Dic 2014||Integrated Vascular Systems, Inc.||Methods and apparatus for locating a surface of a body lumen|
|US8915931||14 Feb 2011||23 Dic 2014||Ethicon Endo-Surgery, Inc.||Surgical clip and applier device and method of use|
|US8920442||23 Ago 2006||30 Dic 2014||Abbott Vascular Inc.||Vascular opening edge eversion methods and apparatuses|
|US8926633||19 Jun 2006||6 Ene 2015||Abbott Laboratories||Apparatus and method for delivering a closure element|
|US8926656||10 Ene 2011||6 Ene 2015||Integated Vascular Systems, Inc.||Clip applier and methods of use|
|US8956388||21 Abr 2008||17 Feb 2015||Integrated Vascular Systems, Inc.||Integrated vascular device with puncture site closure component and sealant|
|US9050068||20 May 2013||9 Jun 2015||Abbott Laboratories||Clip applier and methods of use|
|US9050087||14 May 2008||9 Jun 2015||Integrated Vascular Systems, Inc.||Integrated vascular device with puncture site closure component and sealant and methods of use|
|US9060769||1 May 2008||23 Jun 2015||Abbott Vascular Inc.||Surgical stapler|
|US9089311||8 Ene 2010||28 Jul 2015||Abbott Vascular Inc.||Vessel closure devices and methods|
|US9089674||15 Sep 2006||28 Jul 2015||Integrated Vascular Systems, Inc.||Apparatus and methods for positioning a vascular sheath|
|US20020082621 *||21 Sep 2001||27 Jun 2002||Schurr Marc O.||Methods and devices for folding and securing tissue|
|US20040097927 *||13 Feb 2002||20 May 2004||Yeung Jeffrey E.||Intervertebral disc repair|
|US20040249414 *||11 Dic 2003||9 Dic 2004||Christian Kissel||Medical clip and apparatus for the application of such a clip|
|US20080132915 *||28 Ene 2008||5 Jun 2008||Buckman Robert F||Method and apparatus for vascular and visceral clipping|
|US20100268022 *||5 Abr 2006||21 Oct 2010||Thompson Christopher C||Endoscopic gastric bypass defect repair|
|US20110112558 *||4 Oct 2010||12 May 2011||OC2, LLC, a Massachusetts limited liability company||Tissue fixation system with single component anchor|
|DE3008122A1 *||3 Mar 1980||17 Sep 1981||Zeppelin Dieter Von||Gefaess-klemme|
|DE3019116A1 *||20 May 1980||3 Dic 1981||Aesculap Werke Ag||Tissue ligature clamp - has convex-faced jaws of radius large enough to avoid tissue damage|
|DE3335985A1 *||4 Oct 1983||2 May 1985||Aesculap Werke Ag||Magazin zur aufnahme von c-foermigen scalpclips|
|DE3335986C1 *||4 Oct 1983||4 Abr 1985||Aesculap Werke Ag||Application device for C-shaped scalp clips|
|DE3443367A1 *||28 Nov 1984||13 Jun 1985||Kirsch Wolff Mayer||Chirurgischer mikroklip|
|DE19737976A1 *||30 Ago 1997||18 Mar 1999||Aesculap Ag & Co Kg||Surgical ligature clamp, especially useful as scalp clamp|
|DE19737976C2 *||30 Ago 1997||14 Ago 2003||Aesculap Ag & Co Kg||Chirurgische Ligaturklemme|
|EP0469524A1 *||29 Jul 1991||5 Feb 1992||JOHNSON & JOHNSON PROFESSIONAL, INC.||Surgical clip and surgical clip applier with reciprocating sleeve and dual rachet mechanism|
|EP0490411A1 *||13 Dic 1991||17 Jun 1992||United States Surgical Corporation||Latchless surgical clip|
|WO1988001486A1 *||19 Ago 1987||10 Mar 1988||Wilson H Tucker||Clip applicator and spreadable clips for use therein|
|Clasificación de EE.UU.||606/158, 24/562, 24/DIG.220|
|Clasificación cooperativa||A61B17/1227, Y10S24/22|