|Número de publicación||US3649464 A|
|Tipo de publicación||Concesión|
|Fecha de publicación||14 Mar 1972|
|Fecha de presentación||5 Dic 1969|
|Fecha de prioridad||5 Dic 1969|
|Número de publicación||US 3649464 A, US 3649464A, US-A-3649464, US3649464 A, US3649464A|
|Inventores||Aaron E Freeman|
|Cesionario original||Microbiological Ass Inc|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citada por (138), Clasificaciones (13), Eventos legales (2)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
March 14, 1972 A. E. FREEMAN ASSAY AND CULTURE TRAY 2 Sheets-Sheet 1 Filed Dec. 5. 1969 INVENTOR .I ffii:
IIIII L T AARON E. FREEMAN FIG. 3
Mardi 14, 1972 A, E, FREEMAN 3,649,464
ASSAY AND CULTURE TRAY Filed Dec. 5, 1969 2 Sheets-Sheet 2 FIG. I
INVENT OR AARON E. FREEMAN By a ATTORNEY United States Patent 3,649,464 ASSAY AND CULTURE TRAY Aaron E. Freeman, Rockville, Md., assignor to Microbiological Associates, Inc., Bethesda, Md. Filed Dec. 5, 1969, Ser. No. 882,493 Int. Cl. C12k 1/00 U.S. Cl. 195-140 15 Claims ABSTRACT OF THE DISCLOSURE A plate or tray suitable for assay and cell and tissue culture on a miniature scale comprises a transparent base member made of plastic and having extending upward therefrom a plurality of parallel rows of open top cylindrical wells spaced apart from each other a suicient distance to avoid cross-contamination, an integral peripheral upstanding wall terminating in a flange provided with a seat adapted to receive and sercure a lid having a downwardly extending wall adapted to engage the flange portion of the plate, which lid may include a plurality of parallel rows of downwardly extending well seals positioned to engage the mouth portions of the wells to form closures therefor.
BACKGROUND OF THE INVENTION The rapid expansion of cell and tissue culture, particularly in the iield of virology, has made necessary the processing of large numbers of individual cultures by macrotechniques, employing standard size Petri dishes and other culture vessels. The need for subsequent virus isolation, titration, and assay tests and the like, has involved the handling and manipulation of large numbers of culture vessels and the transfer of substantial volumes of media with attendant space requirements, and hazards of spillage and contamination.
Efforts have been made by virologists and others engaged in cell and tissue culture to utilize for growth, virus assay, neutralization and toxicity tests and the like, the currently available miniature titration or assay plates. These plates are designed for complement-fixation and other serological tests and have proved to be poorly adaptable and generally inadequate for cell and tissue culture purposes. Such assay or titration plates customarily cornprise a one piece molded plastic shell including a plurality of parallel rows of uniformly arranged cups which depend downwardly from a top wall which contains the open upper ends of the cups, tangentially disposed to each other, the closed lower ends being individually formed at the bottoms of the respective cups. When it is attempted to utilize such assay plates for cell and tissue culture purposes, one drawback is the possible cross-contamination of viruses, reagents and cells from one cup or well to another because of the arrangement of the cups whereby the fact that their openings are flush with the top wall surface permits any spillage to llow from one cup into another, which spillage may even result in possible contamination of an entire incubator where the plate is being used in an incubator.
The commercially available miniature titration plates employ a standard type of tape sealing system to cover the well openings and when an eifort is made to use such plates for cell or tissue culture purposes, the tape presents the danger of causing cross-contamination through a mechanical action.
Accordingly, there has existed a need for a cell and tissue culture and assay plate, particularly adapted for cell and tissue culture and attendant assays on a miniature scale and which would be free from the drawbacks of other types of plates not designed specifically for cell and tissue culture purposes.
GENERAL DESCRIPTION OF THE INVENTION In accordance with the present invention, there is provided a novel cell and tissue culture and assay plate, capable of multiple culturing or assaying on a miniature scale, together with a special lid or cover therefor.
The miniature plate of the invention comprises a transparent integral molded base from which there extend upward a multiplicity of small cups or wells arranged in rows, which are capable of functioning as culture vessels for cell or tissue culture, or as cups for microassay work. The outer walls of the cups or wells protrude upward, and are spaced apart from each other, and are not adjoined by an upper wall surface, thereby eliminating the possibility of spillage flowing from one well to another, by reason of the troughs made between adjacent cups or wells. This serves to prevent cross-contamination when the cups are employed for cell or tissue culture Work. The plate is also provided with an upstanding peripheral wall which forms a trough with the bottom of the plate and serves to prevent external spillage.
These and other novel features and advantages of the plate of the invention will be better understood by reference the accompanying drawings, in which:
FIG. 1 is a top plan View of the miniculture plate showing the arrangement of the cups or wells;
FIG. 2 is a section taken through the plate of FIG. l, taken along the line 2 2 of FIG. 1;
FIG. 3 is a top plan View of a particular form of the lid or cover;
FIG. 4 is a cross-sectional view of the lid of FIG. 3 taken along the line 4 4;
FIG. 5 is a cross-sectional view of another form of the lid or cover provided with well-sealing means;
FIG. 6 is a view in perspective of a type of well sealing means;
FIG. 7 is a cross-sectional view showing the interrelationship of two stacked trays;
FIG. 8 is a cross-sectional view showing the interrelationship of a tray covered with a lid and a second tray superimposed thereon; and
FIG. 9 is a View in perspective of the bottom of a tray showing the peripheral bead thereon.
Referring now to the drawings, IFIG. 1 illustrates a presently preferred embodiment of the in'vention, in which the miniature culture or assay plate is shovm generally at 10, and includes a bottom tray 11 from which there extend upward `a plurality of rows of cups or wells 12, each having a thin `wall 13. These cup walls are spaced apart from each other to form troughs between them and to avoid any danger of cross-contamination of the individual cups or wells by reason of spillage or overflow of the well contents. The cups are of equal depth and diameter. Thus, for example, the typical dimension of a well is ka wall height of approximately l0 mm., the wall having an inside diameter of approximately 7.5 mm. The space between adjacent outside Wall surfaces is Iafbout 1 mm. which will ordinarily suffice to avoid the cross-contamination referred to above. The cups may be of any desired shape, but are preferably cylindrical.
The plate is preferably integrally molded of `a suitable transparent plastic material, for example a vinyl resin material, or methyl methacrylate type material, which exhibits high mechanical strength, light weight, is readily cleaned if the plate is to be re-used, and which is suiciently inexpensive so that the plate (and cover) may be treated as disposable.
In the embodiment shown in FIG. 1, the general dimensions of the plate or tray will typically comprise, for example, an over-all length of about 124 mm., and a width of about 80 mm. One corner of the plate is provided with a cut-oil beveled edge 14. This permits design of the lid to have the same configuration as the plate itself, and forces the user to replace the lid in its original position, eliminating cntamination and other difficulties which might arise from replacing the lid in the wrong position.
In the preferred embodiment shown in FIG. l, there are 12 rows of cups or wells, each row containing 8 cups, providing a total of 96. However, it will be understood that the number of cups and their arrangement may be varied yas circumstances require. The trav 11 may be, for example, about 3 mm. thick.
Referring to FIG. 2, there extends peripherally around the edge of the tray 11 an upstanding wall 15, which is molded integrally therewith, the main portion of which wall advantageously has an over-all height equal to approximately one-half the height of the cups or wells, i.e. about 5 mm., but this is not critical. The wall terminates in an integral iiange 16, having a `seat 17 formed by an extension of the Awall which serves to seat and secure the lid 20, as described below.
Por purposes of tray stacking, the tray 11 of the plate is provided with a downwardly extending peripheral bead or lug 18, which is adapted to tit around and encompass the outer limit of the array of wells 19 so that when one tray is stacked on top of another without the lid 20, the upper tray is anchored and cannot slide off. The bead 18, in addition to permitting stacking of the plates, also serves to prevent the bottom of the plate from being scratched when laid on a surface, thus preserving its optical qualities. The arrangement of 4bead 18 will be more clearly understood by reference to FIG. 9.
The microculture plate of the invention may be provided with a suitable lid or cover, the basic version of which is illustrated in FIGS. 3 and 4. The lid 20 is advantageously made of transparent plastic material, and is integrally molded. It includes a substantially at wall 21, which merges into a downwardly extending peripheral wall 22 as shown in FIGS. 4 and 5. The lid is so designed that the wall height is sufficient, when the lid is seated over the miniculture plate 10, to provide a clearance between t-he tops 19 of the wells 12 and the lower surface 21a of the lid wall 21. Typically, 'such clearance may be, for example, about 2 to 3 mm. The lid has a conliguration matching that of the plate itself, that is, it is provided with the cut-off or bevel corner 23, to engage the plate in a single position. In the embodiment shown in FIGS. 3 and 4, the lid wall terminates in a ange portion 24, as shown in TIG. 4, having an inner lug 25, to engage the edge of the ange 16 and the seat 17 at the upper end of the plate Wall 15. This minimizes possible contamination.
This tray stacking principle is illustrated more clearly in FIG. 7, showing the inter-relationship of the bead 18 and the wells 19, with respect to the wall ange portions 16 and 17, the function of the bead 18 here being to prevent lateral sliding of the upper tray. When trays are thus stacked, the wells can be sealed with the sealing strip illustrated in FIG. 6, and described below.
-Extending upward from the lid wall 21 is a peripheral lug 26 which serves to engage the downwardly extending bead 18 of the plate 10, when a set of plates and lids is stacked. This principle is illustrated in FIG. 8. When the lid is applied to the tray, the outer edge of the lid peripheral wall 22 does not extend beyond the edge of flange 16 of the tray, so that the protruding iiange portion 16 of the tray permits grasping and lifting of the tray without the danger of grasping the lid and having the tray drop ott. I
In a modied version of the lid shown in FIG. 5, there are provided integrally molded well seals 27, which extend downwardly from the lid wall 21, in a number matching the number of cups or wells, and positioned so as to engage the mouth portion 19 of the wells by penetrating into the well openings. For this purpose the well seal walls 28 are tapered so that they wedge into the well, providing a positive seal.
The form of well seal shown in FIG. 6 is intended to be used as the sealing means for a given row of wells, or to be used in conjunction with the form of lid shown in FIG. 4. It comprises ya strip 30 of a transparent plastic material having integrally molded therein a set of 12 or 8 individual well seals 31 which are adapted to extend into the mouths 19 of the individual wells. The well seals 31 advantageously have tapering walls of the type described in connection with the embodiment of FIG. 5. The strip may be utilized so that the S rows of 12 wells can be sealed individually, or conversely, if an 8-seal strip is used, so that the 12 rows of 8 each can be thus sealed. In this way the user can remoive the sealing strip from one row at a time without unsealing the remaining 7 or 11 rows of wells. Tab 32 forming one end of strip 30 is provided for this purpose.
What is claimed is:
1. A cell and tissue culture and assay plate comprising a transparent substantially planar base member having integrally molded therein and extending upward therefrom a plurality of parallel rows of upstanding open top cups or wells, said wells being spaced apart from each other to form troughs between them and to avoid cross-contamination of the well contents, said base member including a peripheral upstanding wall integral therewith, and means at the upper end of said wall adapted to receive a lid or cover.
2. The plate according to claim 1, in which said plate is made of a transparent plastic material.
3. The plate according to claim 1, in -which said wells are arranged in transversely aligned rows containing an equal number of Wells.
4. The plate according to claim 1, in which said peripheral wall forms a trough with the bottom of the plate.
5. The plate according to claim 1, in which the height of said peripheral wall is less than the height of said wells.
6. The plate according to claim 1, in which the height of said peripheral wall is approximately one-half the height of Isaid wells and wherein said plate includes a lid secured to said means at the upper end of said wall.
7. The plate according to claim 1, in which said peripheral wall terminates in an integral ange provided with a seal adapted to receive a lid or cover.
8. The plate accor-ding to claim 1, which includes a downwardly extending peripheral bead adapted to prevent scratching of the bottom of the plate and to permit stacking upon another plate or upon the lid or cover of a plate.
9. The plate according to claim 8, in which said peripheral bead is adapted to tit around the outer limit of the cups or wells.
10. The plate according to claim 1, which includes, in combination, a lid comprising a transparent substantially planar member including a peripheral downwardly depending wall integral therewith, the lower edge of said wall including a ange portion adapted to seat and secure the lid in the receiving portion of said plate wall, the wall of said lid being of suliicient height to provide a clearance between the bottom surface of the lid and the upper ends of the wells.
11. The plate according to claim 6, in which both the plate and the lid are provided with a matching cut-off corner portion to align said plate and lid in predetermined position.
12. The plate according to claim 6, in which said lid includes a plurality of parallel rows of integral well seals extending downwardly from the inner surface of the lid, said seals being positioned to register with and to engage the mouth portions of the wells to form closures therefor.
13. The plate according to claim 6, in which said lid includes a peripheral upwardly extending bead positioned adjacent the outer edge of the upper surface of the lid, and which is adapted to engage the peripheral bead extending downwardly from the bottom edge of a similar plate, when plate is stacked or superimposed thereon.
5 6 14. The plate according to claim 1, in which the mouths References Cited of said wells are sealed with a exible strip sealing mem- UNITED STATES PATENTS ber including a plurality of intgeral well seals positioned to register with and to engage the mouth portions of said 3,356,452 12/1967 Cooke et al 23"292 lltof lo thf, t"1d' dghingfagrefnbes ere or sald s p mc mg a e 5 A.LoU1s MoNACELLPnmary Examiner 15. The plate according to claim 6, in which the outer R, M, ELLIOTT, Assistant Examiner edge of the lid peripheral wall does not extend beyond the U S Cl X R surface said peripheral plate wall to permit lifting of the plate and lid simply by grasping the plate edge. 10 23--292z 220-21
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3768914 *||18 Sep 1972||30 Oct 1973||Kinney T||Electron microscopy tissue grid staining and storing rack and method|
|US3802592 *||26 May 1972||9 Abr 1974||Wheaton Industries||Compartmented tray|
|US4154795 *||21 Jul 1977||15 May 1979||Dynatech Holdings Limited||Microtest plates|
|US4239853 *||22 Ene 1979||16 Dic 1980||Bradley Rex L||Antibiotic testing method and apparatus having a channelized reservoir|
|US4284725 *||13 Ago 1976||18 Ago 1981||Dynasciences Corporation||Virus titration and identification system|
|US4526690 *||4 Feb 1983||2 Jul 1985||Millipore Corporation||Apparatus for nucleic acid quantification|
|US4599314 *||14 Jun 1983||8 Jul 1986||Hsc Research Development Corporation||Multiple vessel specimen tray with lid for releasably adhering vessel covers|
|US4657867 *||1 Nov 1984||14 Abr 1987||Becton, Dickinson And Company||Multiwell tissue culture assembly with features for reduced media evaporation|
|US4704255 *||15 Jul 1983||3 Nov 1987||Pandex Laboratories, Inc.||Assay cartridge|
|US4734192 *||21 Jun 1985||29 Mar 1988||Millipore Corporation||Multiwell membrane filtration apparatus|
|US4734373 *||24 Jun 1986||29 Mar 1988||Bartal Arie H||Apparatus for enhancing cell growth, preservation and transport|
|US4829006 *||1 Feb 1988||9 May 1989||Difco Laboratories||Centrifugation vial and cluster tray|
|US4877659 *||2 Ago 1988||31 Oct 1989||Inti Corporation||Multiwell assay/culture strip|
|US4898278 *||19 Sep 1988||6 Feb 1990||Nalge Company||Storage container|
|US4956150 *||15 Nov 1989||11 Sep 1990||Alerchek||Disposable microtiter stick|
|US5021351 *||20 Mar 1986||4 Jun 1991||Becton, Dickinson And Company||Petri dish|
|US5084246 *||28 Oct 1986||28 Ene 1992||Costar Corporation||Multi-well test plate|
|US5096676 *||2 Ago 1990||17 Mar 1992||Mcpherson Alexander||Crystal growing apparatus|
|US5099992 *||13 Jul 1990||31 Mar 1992||Bent Heimreid||Arrangement in connection with a rack for orderly storage and/or for keeping syringes with a luer tip ready for use|
|US5108704 *||16 Sep 1988||28 Abr 1992||W. R. Grace & Co.-Conn.||Microfiltration apparatus with radially spaced nozzles|
|US5110556 *||22 Ago 1991||5 May 1992||Costar Corporation||Multi-well test plate|
|US5130105 *||23 Oct 1990||14 Jul 1992||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Protein crystal growth tray assembly|
|US5141718 *||30 Oct 1990||25 Ago 1992||Millipore Corporation||Test plate apparatus|
|US5394988 *||20 Dic 1993||7 Mar 1995||Johnson & Johnson Vision Products, Inc.||Pallet for receiving and transporting ophthalmic lens containers|
|US5422270 *||19 May 1987||6 Jun 1995||The United States Of America As Represented By The Department Of Health And Human Services||One-step tray test for release of soluble mediators and apparatus therefore|
|US5460783 *||14 Jun 1994||24 Oct 1995||Synbiotics Corporation||Apparatus for automatically removing microtiter well-strips from well-strip holders|
|US5496502 *||18 Nov 1994||5 Mar 1996||Packard Instrument, B.V.||Adhesive plastic scintillator|
|US5501982 *||2 Jun 1995||26 Mar 1996||Abbott Laboratories||Method of using a disposable reagent pack|
|US5508005 *||26 Oct 1993||16 Abr 1996||Costar Corporation||Non-screeching laboratory article|
|US5512753 *||8 Jun 1994||30 Abr 1996||Packard Instrument, B.V.||Scintillation counting system using scintillator capsules|
|US5514343 *||22 Jun 1994||7 May 1996||Nunc, As||Microtitration system|
|US5540891 *||11 Oct 1994||30 Jul 1996||Scheizerische Eidgenossenschaft Vertreten Durch Das Ac-Laboratorium Spiez Der Gruppe Fur Rustungsdienste||Multi-well titerplate for instrumental analysis|
|US5603899 *||12 Abr 1995||18 Feb 1997||Pharmacia Biotech, Inc.||Multiple column chromatography assembly|
|US5650125 *||14 Oct 1993||22 Jul 1997||Bosanquet; Andrew George||Method and apparatus for conducting tests|
|US5792426 *||24 Jun 1996||11 Ago 1998||Schweizerische Eidgenossenschaft Vertreten Durch Das Ac-Laboratorium Spiez Der Gruppe Rustung||Multi-well titerplate for instrumental analysis|
|US5792654 *||11 Nov 1997||11 Ago 1998||Neogen Corporation||Microorganism culture tray|
|US5866825 *||15 Ago 1997||2 Feb 1999||Opaljena Gesellschaft Fuer Optische Analytik Und Labortechnik Mbh||Rinsing tray for multipipetting device|
|US5961926 *||27 Sep 1993||5 Oct 1999||Packard Instrument Co., Inc.||Microplate assembly and method of preparing samples for analysis in a microplate assembly|
|US5985594 *||6 Nov 1996||16 Nov 1999||Idexx Laboratories, Inc.||Method for quantification of biological material in a sample|
|US6074614 *||19 Jun 1997||13 Jun 2000||Molecular Devices Corporation||Multi-assay plate cover for elimination of meniscus|
|US6096562 *||27 Oct 1997||1 Ago 2000||Nalge Nunc International Corporation||Multi-slide assembly including slide, frame and strip cap, and methods thereof|
|US6106783 *||30 Jun 1998||22 Ago 2000||Microliter Analytical Supplies, Inc.||Microplate assembly and closure|
|US6118582 *||12 Jul 1999||12 Sep 2000||Immuno Concepts, Inc.||Slide holder|
|US6196026||1 Mar 1999||6 Mar 2001||Corning Incorporated||Method of making a glass array plate with closure|
|US6232124||13 Nov 1998||15 May 2001||Verification Technologies, Inc.||Automated fingerprint methods and chemistry for product authentication and monitoring|
|US6287797||26 Mar 1999||11 Sep 2001||Biocontrol Systems, Inc.||Method for quantification of biological material in a sample|
|US6383820||22 Feb 2000||7 May 2002||Nalge Nunc International Corporation||Multi-slide assembly including slide, frame and strip cap, and methods thereof|
|US6458595||24 Ene 2001||1 Oct 2002||Verification Technologies, Inc.||Automated fingerprint methods and chemistry for product authentication and monitoring|
|US6475444 *||20 Jul 2000||5 Nov 2002||Cybio Instruments Gmbh||Rinsing tray system|
|US6490030||18 Ene 1999||3 Dic 2002||Verification Technologies, Inc.||Portable product authentication device|
|US6509168||18 Abr 2001||21 Ene 2003||Biocontrol Systems, Inc.||Method for quantification of biological material in a sample|
|US6512580||27 Oct 1999||28 Ene 2003||Verification Technologies, Inc.||Method and apparatus for portable product authentication|
|US6589626||29 Mar 2001||8 Jul 2003||Verification Technologies, Inc.||Copy-protected optical media and method of manufacture thereof|
|US6638593||12 Jun 2001||28 Oct 2003||Verification Technologies, Inc.||Copy-protected optical media and method of manufacture thereof|
|US6707539||18 Oct 2002||16 Mar 2004||Verification Technologies, Inc.||Portable product authentication device|
|US6803239||6 May 2002||12 Oct 2004||Nalge Nunc International Corporation||Multi-slide assembly including slide, frame and strip cap, and methods thereof|
|US6908594 *||18 Oct 2000||21 Jun 2005||Aclara Biosciences, Inc.||Efficient microfluidic sealing|
|US6918738||11 Mar 2002||19 Jul 2005||Diversa Corporation||Stackable sample holding plate with robot removable lid|
|US7079230||24 Abr 2000||18 Jul 2006||Sun Chemical B.V.||Portable authentication device and method of authenticating products or product packaging|
|US7122338||21 Ene 2003||17 Oct 2006||Biocontrol Systems, Inc.||Method for quantification of biological material in a sample|
|US7124944||2 Oct 2002||24 Oct 2006||Verification Technologies, Inc.||Product packaging including digital data|
|US7303803||1 Dic 2004||4 Dic 2007||Verification Technologies, Inc.||Copy-protected optical media and method of manufacture thereof|
|US7316805||2 Sep 2000||8 Ene 2008||Qiagen, Inc.||Laboratory cap and well for hanging-drop crystallization methods|
|US7486790||3 Ago 2000||3 Feb 2009||Verification Technologies, Inc.||Method and apparatus for controlling access to storage media|
|US7527020||13 Dic 2005||5 May 2009||Innovive, Inc.||Containment systems and components for animal husbandry|
|US7660415||6 Dic 2004||9 Feb 2010||Selinfreund Richard H||Method and apparatus for controlling access to storage media|
|US7661392||2 Abr 2007||16 Feb 2010||Innovive, Inc.||Containment systems and components for animal husbandry: nested cage bases|
|US7665419||2 Abr 2007||23 Feb 2010||Innovive, Inc.||Containment systems and components for animal husbandry: cover with air supply apertures|
|US7734381||2 Abr 2007||8 Jun 2010||Innovive, Inc.||Controller for regulating airflow in rodent containment system|
|US7739984||2 Abr 2007||22 Jun 2010||Innovive, Inc.||Containment systems and components for animal husbandry: cage racks|
|US7874268||2 Abr 2007||25 Ene 2011||Innovive, Inc.||Method for adjusting airflow in a rodent containment cage|
|US7913650||29 Abr 2009||29 Mar 2011||Innovive, Inc.||Containment systems and components for animal husbandry|
|US7954455||13 Jun 2006||7 Jun 2011||Innovive, Inc.||Cage cover with filter, shield and nozzle receptacle|
|US7970495||4 Jun 2010||28 Jun 2011||Innovive, Inc.||Method for regulating airflow in a rodent containment system|
|US8007744||16 Ene 2004||30 Ago 2011||Greiner Bio-One Gmbh||Sample container for analyses|
|US8082885||2 Abr 2007||27 Dic 2011||Innovive, Inc.||Containment systems and components for animal husbandry: rack module assembly method|
|US8156899||2 Abr 2007||17 Abr 2012||Innovive Inc.||Containment systems and components for animal husbandry: nested covers|
|US8171887||25 Ago 2011||8 May 2012||Innovive Inc.||Containment systems and components for animal husbandry|
|US8739737||6 Nov 2009||3 Jun 2014||Innovive, Inc.||Rack system and monitoring for animal husbandry|
|US9005549||29 Ene 2006||14 Abr 2015||Greiner Bio-One Gmbh||High throughput polymer-based microarray slide|
|US9066494||19 Feb 2013||30 Jun 2015||Innovive, Inc.||Containment systems and components for animal husbandry|
|US9155283||10 Abr 2008||13 Oct 2015||Innovive, Inc.||Animal husbandry drawer caging|
|US9265229||22 Feb 2013||23 Feb 2016||Innovive, Inc.||Cage cover with filter, shield and nozzle receptacle|
|US20020009397 *||6 Jun 2001||24 Ene 2002||Taisuke Hirono||Cuvette stand and stand with cuvettes|
|US20030047610 *||2 Oct 2002||13 Mar 2003||Selinfreund Richard H.||Product packaging including digital data|
|US20030054543 *||1 Nov 2002||20 Mar 2003||Lafferty William Michael||Device for moving a selected station of a holding plate to a predetermined location for interaction with a probe|
|US20030112423 *||18 Oct 2002||19 Jun 2003||Rakesh Vig||On-line verification of an authentication mark applied to products or product packaging|
|US20030235519 *||24 Jun 2002||25 Dic 2003||Corning Incorporated||Protein crystallography hanging drop lid that individually covers each of the wells in a microplate|
|US20040000787 *||31 Ene 2003||1 Ene 2004||Rakesh Vig||Authentication mark for a product or product package|
|US20040018585 *||21 Ene 2003||29 Ene 2004||Crouteau Andrew J.||Method for quantification of biological material in a sample|
|US20040023397 *||5 Ago 2002||5 Feb 2004||Rakesh Vig||Tamper-resistant authentication mark for use in product or product packaging authentication|
|US20040101439 *||21 Nov 2002||27 May 2004||Fusco Adam J||Biological and chemical reaction devices and methods of manufacture|
|US20040118931 *||26 Sep 2003||24 Jun 2004||Selinfreund Richard H.||Authentication of items using transient optical state change materials|
|US20050083829 *||6 Dic 2004||21 Abr 2005||Selinfreund Richard H.||Method and apparatus for controlling access to storage media|
|US20050084645 *||7 Dic 2004||21 Abr 2005||Selinfreund Richard H.||Method and system for optical disc copy-protection|
|US20050224690 *||12 Abr 2004||13 Oct 2005||Hobbs George J||Water-permeable concrete pad and form|
|US20050244956 *||3 May 2005||3 Nov 2005||New York Medical College||Test culture dish|
|US20060023600 *||29 Sep 2005||2 Feb 2006||Verification Technologies, Inc.||Method and apparatus for controling access to storage media|
|US20060066465 *||6 Sep 2005||30 Mar 2006||Gotthilf Koerner||Circuit configuration for analog/digital conversion|
|US20060124072 *||13 Dic 2005||15 Jun 2006||Innovive Llc||Containment systems and components for animal husbandry|
|US20060151322 *||16 Ene 2004||13 Jul 2006||Gunther Knebel||Sample container for analyses|
|US20060171856 *||29 Ene 2006||3 Ago 2006||Heinrich Jehle||High throughput polymer-based microarray slide|
|US20060203700 *||16 May 2006||14 Sep 2006||Verification Technologies, Inc.||Method and system for optical disk copy-protection|
|US20060278171 *||13 Jun 2006||14 Dic 2006||Conger Dee L||Containment systems and components for animal husbandry|
|US20070001011 *||31 Ago 2006||4 Ene 2007||Verification Technologies, Inc.||Product packaging including digital data|
|US20070169714 *||2 Abr 2007||26 Jul 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070169715 *||2 Abr 2007||26 Jul 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070169716 *||2 Abr 2007||26 Jul 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070169717 *||2 Abr 2007||26 Jul 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070169718 *||2 Abr 2007||26 Jul 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070175399 *||2 Abr 2007||2 Ago 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070175404 *||2 Abr 2007||2 Ago 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070181070 *||2 Abr 2007||9 Ago 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070181074 *||2 Abr 2007||9 Ago 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070181075 *||2 Abr 2007||9 Ago 2007||Innovive Inc.||Containment systems and components for animal husbandry|
|US20070184551 *||5 Abr 2007||9 Ago 2007||Jean-Pascal Viola||Crystallization Methods for laboratory cap and well|
|US20080066090 *||24 Oct 2007||13 Mar 2008||Verification Technologies, Inc.||Storage Media Access Control Method and System|
|US20080078332 *||2 Abr 2007||3 Abr 2008||Innovive Inc.||Containment systems and components for animal husbandry|
|US20080134984 *||8 Oct 2007||12 Jun 2008||Conger Dee L||Containment cage liners for animal husbandry|
|US20080144459 *||8 Feb 2008||19 Jun 2008||Verification Technologies, Inc.||Method and apparatus for controlling access to storage media|
|US20080236506 *||2 Abr 2007||2 Oct 2008||Innovive Inc.||Containment systems and components for animal husbandry|
|US20080236507 *||2 Abr 2007||2 Oct 2008||Innovive Inc.||Containment systems and components for animal husbandry|
|US20080282990 *||10 Abr 2008||20 Nov 2008||Innovive, Inc.||Animal husbandry drawer caging|
|US20080293157 *||24 May 2007||27 Nov 2008||Gerald Frederickson||Apparatus and method of performing high-throughput cell-culture studies on biomaterials|
|US20100248611 *||4 Jun 2010||30 Sep 2010||Innovive, Inc.||Controller for regulating airflow in rodent containment system|
|US20110061600 *||17 Ago 2007||17 Mar 2011||Innovive, Inc.||Containment systems and components for animal husbandry|
|USRE34133 *||30 Jun 1988||24 Nov 1992||Dynatech Holdings, Ltd.||Microtest plates|
|USRE38312 *||10 Abr 2001||11 Nov 2003||Microliter Analytical Supplies, Inc.||Microplate assembly and closure|
|DE10321042A1 *||10 May 2003||5 Ago 2004||Greiner Bio-One Gmbh||Probengefäß für Analysen|
|DE10321042B4 *||10 May 2003||21 Sep 2006||Greiner Bio-One Gmbh||Biochip-Träger|
|DE20101080U1 *||20 Ene 2001||6 Jun 2002||Evotec Biosystems Ag||Untersuchungsvorrichtung|
|EP0063744A2 *||14 Abr 1982||3 Nov 1982||Forschungszentrum Jülich Gmbh||Process and apparatus for the series cultivation of microorganisms|
|EP0063744A3 *||14 Abr 1982||16 Nov 1983||Kernforschungsanlage Julich Gesellschaft Mit Beschrankter Haftung||Process and apparatus for the series cultivation of microorganisms|
|EP0098534B1 *||30 Jun 1983||10 Sep 1986||Millipore Corporation||Filter apparatus|
|WO1988000235A1 *||24 Jun 1987||14 Ene 1988||Bartal Arie H||Apparatus for enhancing cell growth, preservation and transport|
|WO1994008716A1 *||4 Oct 1993||28 Abr 1994||Baxter Diagnostics Inc.||Assay cartridge|
|WO1999047460A1 *||16 Feb 1999||23 Sep 1999||Corning Incorporated||Method of making a glass array plate with closure|
|WO2010016822A1 *||7 Ago 2008||11 Feb 2010||Garry Tsaur||Multi-dose container|
|Clasificación de EE.UU.||435/305.2, 206/562, 435/305.3, 220/507, 206/558, 422/510|
|Clasificación internacional||C12M1/20, G11C16/04|
|Clasificación cooperativa||C12M23/12, C12M23/38, G11C16/0466|
|Clasificación europea||G11C16/04M, C12M1/20|
|20 Ago 1984||AS02||Assignment of assignor's interest|
Owner name: DYNASCIENCES CORPORATION, A PA CORP.
Effective date: 19840726
Owner name: WHITTAKER M.A. BIOPRODUCTS, INC., 10880 WILSHIRE B
|20 Ago 1984||AS||Assignment|
Owner name: WHITTAKER M.A. BIOPRODUCTS, INC., 10880 WILSHIRE B
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:DYNASCIENCES CORPORATION, A PA CORP.;REEL/FRAME:004293/0130
Effective date: 19840726