|Número de publicación||US3790079 A|
|Tipo de publicación||Concesión|
|Fecha de publicación||5 Feb 1974|
|Fecha de presentación||5 Jun 1972|
|Fecha de prioridad||5 Jun 1972|
|Número de publicación||US 3790079 A, US 3790079A, US-A-3790079, US3790079 A, US3790079A|
|Inventores||Berglund R, Liu B|
|Cesionario original||Rnb Ass Inc|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citada por (147), Clasificaciones (12)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
United States Patent [191 Berglund et al. A
Feb. 5, 1974 METHOD AND APPARATUS FOR GENERATING MONODISPERSE AEROSOL  Inventors: Richard Berglund, St. Paul;
Benjamin Y. H. Liu, Minneapolis,
both of Minn.
 Assignee: RNB Associates, Inc., Minneapolis,
 Filed: June 5, 1972 211 App]. No.: 259,374
 US. Cl 239/3, 239/4, 239/8,
239/102, 259/D1G. 44  Int. Cl B051) 5/00, BOSb 7/00, B05b 17/06  Field of Search 239/3, 4, 8, 9, 101, 102; 259/DIG. 44
 References Cited UNITED STATES PATENTS I 3,326,467 6/1967 Fortman 239/102 3,433,461 3/1969 Scarpa..- 239/4 X 3,584,412 6/1971 Palmer '239/102 X FOREIGN PATENTS OR APPLICATIONS 205,195 6/1969 U.S.S.R 239/102 1,017,388 9/1952 France 239/102 1,198,514 7/1970 Great Britain.... 239/102 Primary ExaminerRobert S. Ward, Jr. Attorney, Agent, or Firm-L. Paul Bur'd et al.
[5 7] ABSTRACT A vibrating orifice monodisperse aerosol generator usable as a basic aerosol standard having a liquid feed system, 'a droplet generator, a droplet dispersion system and an aerosol flow system. The liquid feed system is a syringe pump operable to feed liquid into the droplet generator. The liquid is discharged from the droplet generator through a small orifice as a liquid jet. The jet disturbed. at a constant frequency with an oscillating piezoelectric ceramic breaks up into uniform droplets. The droplets are dispersed by a turbulent air jet and diluted into a monodispersed aerosol.
38 Claims, 5 Dravving Figures PATENTEU 51974 3.790.079
- SHEET 2 Bf 2 kh 0 O O O O O O METHOD AND APPARATUS FOR GENERATING MONODISPERSE AEROSOL BACKGROUND OF THE INVENTION Basic aerosol standards, consisting of monodispersed aerosols of a high degree of monodispersity and accurately known particle size are needed for a variety of purposes ranging from fundamental aerosol research,
calibration of aerosol sampling and measuring instruments, testing of particulate control devices such as cyclones, filters, scrubbers, and the like, to the study of health, meteorological and other effects of particulate air pollutants. To be generally useful, the aerosol standard must be sufficiently flexible to permit aerosols to be generated from a variety of solid and liquid materials having desired physical properties.
Conventional monodisperse aerosol generators, as the spinning-disc aerosol generator, the atomizerimpactor generator, the condensation generator and the polystyrene latex aerosol generator, all have severe limitations for use as a basic aerosol standard. The spinning-disc generator, while flexible in terms of the aerosol material, can produce aerosols with geometrical standard deviations of not better than 1.07 or a standard deviation of approximately 7 percent of the mean particle size. The spinning-disc generator is also a relatively complex piece of apparatus. The atomizer- -impactor generator can only produce a moderately monodisperse aerosol with a geometrical standard deviation of not better than 1.40. The polystyrene latex generator can produce aerosols from only one material and only of the discrete sizes provided by the polystyrene latex manufacturer. This generator also produces residue particles which are undesirable for'many applications.
Vibrating orifice aerosol generators are based on the principle of the breakup of'a liquid jet. It is known that cylindrical liquid jets are unstable to rotationally symmetric disturbances. These disturbances will grow until the jet breaks. The known droplet generators are not usable as a basic aerosol standard in their present state of development as they need a droplet dispersion system in an aerosol flow system of a well defined geometry to provide stable operation.
SUMMARY OF THE INVENTION means is an apparatus for generatingliquid droplets.
The apparatus has a discharge orifice generally aligned with the outlet opening the housing and spaced from the opening. The housing means includes means providing a chamber between the apparatus and the outlet opening. The liquid is supplied under pressure to the apparatus to generate droplets. The apparatus has means subjected to a vibratory force which breaks the liquid jet into substantially equal size droplets which are discharged into the chamber. Air under pressure is supplied to the chamber, whereby the droplets emanating from the apparatus are dispersed into the air and discharged with the air through the outlet opening. The
dispersed aerosol then enters the aerosol flow system which acts to dilute'and transport the aerosol.
IN THE DRAWINGS FIG. 1 is a schematic view of the aerosol generator flow system of the invention;
FIG. 2 is an enlarged fragmentary sectional view of the aerosol generator of FIG. 1 located in the flow system;
FIG. 3 is a sectional view of the aerosol generator taken along line .3-3 of FIG. 2;
FIG. 4 is an enlarged sectional view of the droplet generator forming part of FIG. 2; and
FIG. 5 is an enlarged sectional view taken along line 5-5 of FIG. 4.
Referring to the drawings, there is shown in FIG. 1 the flow system for the aerosol generator of the' invention, indicated generally at 10. System 10 includes an aerosol generating assembly, indicated generally at 11, containing the aerosol generator 12 for generating droplets and dispersing the droplets in carrier air in the form of a monodispersed aerosol.
As shown in FIG. 2, aerosol generator 12 is mounted on a support or porous plate 13 located over an opening in a housing 14. The outer peripheral edge portion of the plate 13 rests on and is attached to the top of housing 14. The housing 14 surrounds an absolute filter 16 through which the air passes prior to its flow through the porous plate 13. Positioned on top of plate 13 is an elongated tube or cylinder 17 having an elongated chamber 18. The upper end of the cylinder is tapered or cone-shaped and has an outlet opening 19, providing an outlet passage for the discharge of monodispersed aerosol, indicated by arrow 21. A plurality of fasteners 22, as bolts, extend through suitable holes in an outwardly directed flange 17A on the tubular member 17 and aligned holes in plate 13 to secure the tube 17 and plate 13 to the top of housing 14.
Air is supplied to the bottom of housing 14 with a blower 23 having an electric motor (not shown) controlled with a variable transformer 24. Air can also be obtained from'a compressor having appropriate pressure regulators. The outlet of blower 23 is connected to a line or tube 26 leading to the bottom of housing 14.
A control valve 27 interposed in line 26 regulates the flow of air into housing 14. A differential pressure gauge 28 is connected in line 26 before valve 27 and an outlet portion of blower 23 to provide means for determining the pressure of the air being supplied to the housing 14. i
The liquid feed system for the aerosol generator 12 has an infusion pump orsyringe 29 which forces the liquid under pressurethrough a membrane filter 32 interposed in a line 31 connecting the pump 29 to the aerosol generator 12. Other types of pumps can be used to provide the generator 12 with a substantially constant supply of liquid under pressure.
Aerosol generator 12 has a droplet generator or apparatus operable to form liquid droplets, indicated generally at 33 in FIGS. 2 and 4. The air supply system for the generator 33 is diagrammatically shown in FIG. 1. Droplet generator 33 is connected to a high pressure air line 34 providing a supply of air to a pressure regulator 36 and an absolute filter 37. The air flows from filter 37 through a rotameter 38 into a feed line 39 connected to the aerosol generator 12. The droplet generator 33 is subjected to a vibratory force generated with a signal generator 41 coupled via line or conductor 76 to a vibrating portion of the droplet generator 33, as shown in FIG. 4.
As shown in FIG. 2, the aerosol generator 12 has a housing comprising a generally cup-shaped base 42 mounted on the center portion of plate 13. A plurality of fasteners 43, as bolts, attach base 42 to plate 13. Base 42 has an upwardly directed cylindrical side wall 44 surrounding a chamber 46. The top of base 42 is closed wih an inverted, cup-shaped housing member 47 having a generally flat top wall or metal plate 48. The center portion of top wall 48 has an outlet hole or outlet opening 49 located along the axial or longitudinal center line of the chamber located along the axial or longitudinal center line of the chambr r 18. Member 47 has a cylindrical side wall 51 of electrical nonconductive material telescoped over the side wall 44. Fasteners 52, as bolts, secure the walls 44 and 51 together. An annular seal 53 is interposed between walls 44 and 51. The top wall 48 is spaced from and located above the top of the droplet generator 33 forming therewith a space or chamber 54. An annular stop washer 55 secured to the inside of side wall 51 rests on top of the side wall 44. Secured to side wall 51 is an inlet nipple 56 connecting the air line 39 to the generator 12 so that air indicated by arrow 57 is introduced into the chamber 54 and mixed with the droplets emanating from the generator 33. The air is introduced into the side of chamber 54 and is in a turbulent state as it mixes with the droplets. The air and droplet mixture in chamber 54 is discharged through opening 49 into the chamber,18 and is dispersed in a conical pattern, as shown in FIG. 2. The dispersed aerosol is carried with the clean air flowing through porous plate 13 in the chamber 18 toward the outlet opening 19. This clean air functions to dilute and transport the aerosol. In the case of a nonvolatile solute in a volatile solvent, the clean air also evaporates the solvent. The monodispersed aerosol 21 is discharged through the opening 19 at the top of the tube 17. When it is desired to generate a monodispersed aerosol having a unipolar electrical charge, a DC voltage can be applied to the metal plate 48 to induce a charge on the generated droplets.
As shown in FIG. 2, droplet generator 33 is located in chamber 46 of the base'42. An annular O-ring 59 of resilient material, as rubber, surrounds generator 33 to position the generator in chamber 46. The O-ring is in frictional engagement with an annular outer portion of the generator. The outer peripheral portion of O-ring 59 is located in an annular groove 60 in the top of the inside face of side wall 44.
Referring to FIGS. 4 and 5, there is shown droplet generator 33 operable to produce monodispersed liquid droplets. Generator 33 has a housing having a secnd member including generally flat top plate 61. A center portion of plate 61 has a hole or outlet opening 62. Extended downwardly from the bottom side of plate 61 is a cylindrical side wall 63. The plate 61 and side wall 63 form an inverted, generally cup-shaped housing member having an outwardly directed top flange or lip 61A. The inner face of side wall 63 is threaded to accommodate a threaded plug or.cap 64 forming a first housing member. Plug 64 has a longitudinal passageway 66. Line 31 is connected to the plug 64 to provide the inlet port or opening of passageway 66 with fluid under pressure from the infusion pump 29. The inside wall of plate 61 has a circular recess 67 accommodating a removable disc or plate member 68. The center portion of disc 68 has a small discharge orifice or opening 69. The disc 68 is held in recess 67 with an annular resilient member or an O-ring 71. A compressive force is applied to the O-ring 71 by turning plug 64 into the side wall 63. The top face of plug 64 engages O-ring 71 and holds'it in a compressive state against disc 68. The O-ring 71 surrounds a chamber7 2 located at the upper end of passageway 66 adjacent the disc 68. The orifice 69 is in general axial or longitudinal alignment with passageway 66 and outlet opening 49.
An annular means 73 surrounds the side wall 63 and is operable to vibrate the generator 33 at a frequency that breaks the liquid jet into substantially equal sized droplets 77. Annular means 73 is an annular member or ring of piezoelectric ceramic secured to the underside of flange 61A with an epoxy 74, or similar fastening means. Signal generator 41 is electrically coupled to flange 61A and annular means 73 with a line or conductor 76. Epoxy 74 is an electrically conductive fastening adhesive. Other suitable attaching or bonding means can be used to couple the vibrating means to the flange 61A. The inside surface of vibrating means 63 is spaced, indicated at 78, from the outside surface of side wall 63, whereby all the vibratory forces are applied to the plate 61.
In operation, liquid is supplied to generator 33 via the line 31 on operation of pump 29. The liquid flows through passageway 66 into the chamber 72. The liquid is discharged as a jet 75 through the orifice 69 which directs the liquid through hole 62. The signal generator 41 provides a constant frequency AC voltage to the piezoelectric ceramic 73. This AC voltage vibrates the cup-shaped housing structure 61-63 and disturbs the liquid jet 75. Liquid jet 75 breaks up into equal size droplets 77 at the frequency of the AC voltage. The droplets 77 enter the chamber 54. Air 57 enters the chamber 54 in a turbulent state, thereby dispersing the droplets 77. The dispersed droplets and air are discharged into chamber 18 through opening 49 in a conical pattern, indicated at 58 in FIG. 2. The dispersed aerosol is diluted by themoving clean air in chamber 18 and transported to the outlet opening 19. The clean air flows from housing 14 through porous plate 13 in a generally linear configuration whereby the dispersed aerosol is carried generally linearly in the center or core section of chamber 18. I
In terms of method of generating a monodispersed aerosol, the droplet generator 33 functions to discharge a liquid jet 75 through orifice 69. This jet is disturbed with a vibratory force to break the jet into substantially uniform droplets 7 7. The liquid jet 75 is disturbed at a frequency established with an AC voltage on a member, as piezoelectric ceramic ring 73, which will vibrate when subjected to an AC voltage. The droplets 77 are directed into a mixing or dispersion chamber 54 in a direction in general alignment with the outlet opening 49 for the chamber. During the time the droplets are in the chamber 54, they are subject to a flow of turbulent air 57. Both the turbulent air and the dispersed droplets are discharged from chamber 54 through outlet opening 49 into chamber 18 which forms a passage to the outlet opening 19. A stream of cleanair in chamber 18 dilutes the aerosol and carries the dispersed aerosol to the outlet opening 19.
The aerosol generator 12 produces particles that do not have to be measured. The aerosol diameter can be calculated from the liquid flow rate, the disturbance frequency, and non-volatile solute concentration within 0.1 percent error by the'following formula:
Q volumetric flow rat'e,
C volumetric concentration of non-volatile solute in volatile solvent,
f disturbance frequency.
The particles are substantially uniform in that no size difference can be detected between them by using an optical microscope.
While there have been shown and described a preferred apparatus and method for generating a monodispersed aerosol, it is understood that changes in the size, materials, electrical circuits, fluid and air flow systems may be made by those skilled in the art without departing from the spirit of the invention.
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
1. An aerosol generator comprising: housing means having'at least one outlet hole, an apparatus for generating liquid droplets mounted on said housing means, said apparatus having a discharge orifice generally axially aligned with said hole and spaced from said hole, said housing means including means providing a chamber between the apparatus and the outlet hole, means for supplying the apparatus with liquid under pressure whereby the apparatus generates droplets, and means operable to provide air under pressure into the chamber whereby droplets emanating from the apparatus into the chamberare dispersed into the air and discharged with the air from the chamber through the out let hole.
2. The generator of claim 1 wherein: the apparatus for genereating liquid droplets includes means operable to vibrate the apparatus at a frequency whereby substantially equal size droplets are produced.
3. The generator of claim 2 wherein: said means to vibrate the apparatus is an annular means of piezoelectric material.
4. The generator of claim ll including: means to apply a constant frequency AC voltage to said apparatus to vibrate the apparatus whereby the jet of liquid moving from the orifice breaks into substantially equal size droplets related to the frequency of the AC voltage.
5 The generator of claim 1 wherein: said apparatus for generating liquid droplets includes housing means having a first member with a first passage and a second member having anoutlet opening attached to the first member, and means having an orifice located between the first member and the second member.
6. The generator of claim 5 including: an annular member engageable with said first member and said means having an orifice to position said means having an orifice on said housing means.
7. The generator of claim 6 wherein: the annular member is a resilient O-ring.
8. The generator of claim 1 in combination with: a porous support means, tube means having a chamber extended from said support means for receiving aerosol from the generator, said generator being mounted on said porous support means within said tube means with the outlet hole positioned to direct aerosol into the chamber of the tube means, and means to supply air to said porous support means whereby said air transports the dispersed droplets in the chamber of the tube means. I
9. The aerosol generator of claim 8 wherein: said generator is located generally along the longitudinal axis of the tube means and on the support means so that a substantially uniform cylindrical core of air surrounds the generator and aerosol discharged therefrom.
10. The generator of claim 1 wherein: the housing means has a side wall surrounding a chamber, said apparatus for generating liquid droplets being located in said chamber, and resilient means mounting said apparatus on said side wall. I
11. The generator of claim 10 wherein: the resilient means is an annular O-ring surrounding and engaging the apparatus and side wall.
12. An apparatus usable with a source of liquid under pressure to generate droplets comprising: housing means having a passageway, an inlet opening, and an outlet opening in communication with the passageway, disc means having an orifice mounted on said housing means, said orifice being open to liquid from said passageway whereby a jet of liquid is discharged from the orifice, means secured to the housing means operable to vibrate the disc means at a frequency that breaks up tially equal size droplets.
13. The apparatus of claim 12 wherein: said means secured to the housing means is an annular member of piezoelectric material.
14. The apparatus of claim 13 wherein: said material of the annular member is a piezoelectric ceramic.
15. The apparatus of claim 13 including: meansto apply a constant frequency AC voltage to said annular member to cause said housing means to vibrate whereby the jet of liquid moving from the orifice breaks up into substantially equalsize droplets related to the frequency of the AC voltage.
16. The apparatus of claim 12 wherein: said housing means includes a first member having a first passageway and said inlet opening, and a second member having said outlet opening attached to the first member,
a cylindrical portion attached to said cylindrical wall.
18. An apparatus usable with a source of liquid under pressure to generate droplets comprising: housing "means having a passageway, an inlet opening, and an outlet opening in communication with the passageway,
means having an orifice mounted on said housing means, said orifice being generally axially aligned with said outlet opening to direct a jet of liquid through the outlet opening, said housing means including a first member having a first passageway and said inlet opening and a second member having said outlet opening attachedto the first member, said means having an orifice being located between said first member and said second member, and annular means engageable with said first member and said means having an orifice to position said means having an orifice on the housing means.
19. The apparatus of claim 18 wherein: the annular means is a resilient O-ring.
20. The apparatus of claim 18 wherein: said second member has a recess surrounding the inlet opening, a disc means being located in said recess.
21. The apparatus of claim 12 wherein: said orifice in the disc means is a hole generally in the center portion of said disc means.
22. The apparatus of claim 12 wherein: the housing means comprises a first member having a generally flat portion, cylindrical side wall portion and an outwardly directed flange portion, said outlet opening being in said generally flat portion, and a second member attached to the side wall portion, said disc means being located between the first member and second member, and said means operable to vibrate the housing means being secured to the flange portion.
23. The apparatus of claim 22 wherein: the flat portion has an inwardly open recess, said disc means having an orifice is located in said recess, and resilient means engageable with the disc means and second member whereby the second member holds the disc means in said recess.
24. The apparatus of claim 23 wherein: the resilient means is an O-ring.
25. The apparatus of claim 22 wherein: the said means operable to vibrate the housing is a piezoelectric ceramic ring surrounding the side wall portion and secured to the flange portion.
26. A method of generating a monodispersed aerosol comprising: discharging a liquid jet through an orifice in a member, vibrating the member to break up the liquid jet passing through the orifice into substantially uniform droplets, subjecting the droplets to a flow of turbulent air to disperse the droplets in the air, and discharging the droplets to a selected location.
27. The method of claim 26 wherein: the droplets are discharged into a stream of moving air which dilutes and transports the aerosol.
28. The method of claim 26 wherein: the member is vibrated at a frequency established by an AC voltage.
29. The method of claim 26 wherein: the liquid jet is discharged into a chamber having an outlet opening, said turbulent air being introduced into said chamber, and said droplets and turbulent air being discharged through said outlet opening.
30. The method of claim 26 wherein: the liquid jet is discharged in a direction in general alignment with the outlet opening for the chamber.
31. The method of claim 26 wherein: the droplets are subjected to a DC voltage to induce a unipolar electrical charge on the aerosol.
32. An apparatus usable with a source of liquid under pressure to generate substantially equalized droplets comprising: housing means having a passageway, an inlet opening and an outlet opening in communication with the passageway whereby the liquid can flow through said housing means, means having an orifice mounted on said housing means between said inlet opening and said outlet opening, said orifice being open to liquid from said passageway whereby a jet of liquid is discharged fom the orifice, means secured to the housing means operable to vibrate the means having an orifice at a frequency that breaks up the jet of liquid moving from the orifice into substantially equal size droplets, said means secured to the housing means being an annular member of piezoelectric material surrounding said housing means.
33. The apparatus of claim 32 wherein: said means having an orifice is a disc having a hole.
34. The apparatus of claim 32 wherein: the housing means comprises a first member having said outlet opening and a second member secured to the first member having the inlet opening, said means having an orifice being located between said first member and second member.
35. The apparatus of claim 34 including: resilient means engageable with one of said members and the means having an orifice to position the means having the orifice on the other member.
36. The apparatus of claim 34 wherein: one member has an inwardly open recess, said means having an orifice being located in said recess, and means engageable with said means having an orifice and the other member to hold the means having an orifice in said recess.
37. The apparatus of claim 36-wherein: said means is a resilient O-ring.
38. The apparatus of claim 34 wherein: said one member has an outwardly directed flange, said annular member of piezoelectric material being secured to said flange.
P0-1050 UNITED STATES PATENT OFFICE 5 CERTIFICATE U1" CORRECTION iPatent No. 3 790 U79 Dated February 5 1974 Inventor(s) Richard N. Berglund et a1 It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:
Column 3, lines 14-15, "located along the axial or longitudinal center line of the chambr r" is repetitious and should be omitted Column 3, line 47, after "O-ring", 59" is omitted.
Column 3, line 60, after "directed", 'annular is omitted.
Claim 25, line 2, after "housing", --means is omitted.
Signed and sealed this 17th day of September 19M.
McCOY GIBSON JR. C. MARSHALL DANN Attesting Officer Commissioner of Patents
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3897905 *||19 Oct 1973||5 Ago 1975||Universal Oil Prod Co||Electrostatic spraying nozzle|
|US3966120 *||12 Mar 1975||29 Jun 1976||Parker-Hannifin Corporation||Ultrasonic spraying device|
|US3969208 *||8 Abr 1974||13 Jul 1976||The Fujikura Cable Works, Ltd.||Ultrasonic apparatus|
|US4044297 *||5 Dic 1975||23 Ago 1977||Matsushita Electric Industrial Co., Ltd.||Ultrasonic generator with combined oscillator and current regulator|
|US4052004 *||18 Feb 1976||4 Oct 1977||Plessey Handel Und Investments A.G.||Vibratory atomizer|
|US4087495 *||23 Mar 1977||2 May 1978||Mikuni Kogyo Kabushiki Kaisha||Ultrasonic air humidifying apparatus|
|US4344402 *||13 Dic 1979||17 Ago 1982||Child Francis W||Fuel supply system|
|US4344403 *||13 Dic 1979||17 Ago 1982||Child Frances W||Fuel supply system|
|US4344404 *||21 Dic 1979||17 Ago 1982||Child Francis W||Fuel supply system|
|US4352459 *||3 Dic 1979||5 Oct 1982||Sono-Tek Corporation||Ultrasonic liquid atomizer having an axially-extending liquid feed passage|
|US4533082 *||14 Oct 1982||6 Ago 1985||Matsushita Electric Industrial Company, Limited||Piezoelectric oscillated nozzle|
|US4605167 *||17 Ene 1983||12 Ago 1986||Matsushita Electric Industrial Company, Limited||Ultrasonic liquid ejecting apparatus|
|US4702418 *||9 Sep 1985||27 Oct 1987||Piezo Electric Products, Inc.||Aerosol dispenser|
|US4871489 *||19 Abr 1988||3 Oct 1989||Corning Incorporated||Spherical particles having narrow size distribution made by ultrasonic vibration|
|US5152456 *||3 Dic 1990||6 Oct 1992||Bespak, Plc||Dispensing apparatus having a perforate outlet member and a vibrating device|
|US5173274 *||16 Ago 1991||22 Dic 1992||Southwest Research Institute||Flash liquid aerosol production method and appartus|
|US5198157 *||20 Ago 1991||30 Mar 1993||Dynamad S. A. R. L.||Ultrasonic device for the continuous production of particles|
|US5261601 *||6 Jul 1992||16 Nov 1993||Bespak Plc||Liquid dispensing apparatus having a vibrating perforate membrane|
|US5316970 *||5 Jun 1992||31 May 1994||International Business Machines Corporation||Generation of ionized air for semiconductor chips|
|US5409163 *||22 Nov 1993||25 Abr 1995||Ultrasonic Systems, Inc.||Ultrasonic spray coating system with enhanced spray control|
|US5432670 *||13 Dic 1993||11 Jul 1995||International Business Machines Corporation||Generation of ionized air for semiconductor chips|
|US5725153 *||10 Ene 1995||10 Mar 1998||Georgia Tech Research Corporation||Oscillating capillary nebulizer|
|US5848751 *||7 Oct 1997||15 Dic 1998||Georgia Tech Research Corporation||Oscillating capillary nebulizer|
|US5938117 *||5 Abr 1995||17 Ago 1999||Aerogen, Inc.||Methods and apparatus for dispensing liquids as an atomized spray|
|US5994029 *||30 Mar 1998||30 Nov 1999||Agfa-Gevaert Ag||Dulled radiation-sensitive recording material and process for its production|
|US6014970 *||11 Jun 1998||18 Ene 2000||Aerogen, Inc.||Methods and apparatus for storing chemical compounds in a portable inhaler|
|US6062212 *||25 Oct 1993||16 May 2000||Bespak Plc||Dispensing apparatus|
|US6126086 *||5 Dic 1997||3 Oct 2000||Georgia Tech Research Corp.||Oscillating capillary nebulizer with electrospray|
|US6205999||8 Sep 1998||27 Mar 2001||Aerogen, Inc.||Methods and apparatus for storing chemical compounds in a portable inhaler|
|US6235177||9 Sep 1999||22 May 2001||Aerogen, Inc.||Method for the construction of an aperture plate for dispensing liquid droplets|
|US6293474||7 Feb 2000||25 Sep 2001||S. C. Johnson & Son, Inc.||Delivery system for dispensing volatiles|
|US6467476||18 May 2000||22 Oct 2002||Aerogen, Inc.||Liquid dispensing apparatus and methods|
|US6540153||27 May 1999||1 Abr 2003||Aerogen, Inc.||Methods and apparatus for dispensing liquids as an atomized spray|
|US6543443||12 Jul 2000||8 Abr 2003||Aerogen, Inc.||Methods and devices for nebulizing fluids|
|US6546927||13 Mar 2001||15 Abr 2003||Aerogen, Inc.||Methods and apparatus for controlling piezoelectric vibration|
|US6550472||16 Mar 2001||22 Abr 2003||Aerogen, Inc.||Devices and methods for nebulizing fluids using flow directors|
|US6554201||2 May 2001||29 Abr 2003||Aerogen, Inc.||Insert molded aerosol generator and methods|
|US6629646||7 Dic 1993||7 Oct 2003||Aerogen, Inc.||Droplet ejector with oscillating tapered aperture|
|US6640804||15 Ago 2002||4 Nov 2003||Aerogen, Inc.||Liquid dispensing apparatus and methods|
|US6732944||2 May 2001||11 May 2004||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US6755189||18 May 1999||29 Jun 2004||Aerogen, Inc.||Methods and apparatus for storing chemical compounds in a portable inhaler|
|US6782886||20 Mar 2001||31 Ago 2004||Aerogen, Inc.||Metering pumps for an aerosolizer|
|US6948491||20 Mar 2001||27 Sep 2005||Aerogen, Inc.||Convertible fluid feed system with comformable reservoir and methods|
|US6978941||9 Abr 2004||27 Dic 2005||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US7032590||5 Ene 2004||25 Abr 2006||Aerogen, Inc.||Fluid filled ampoules and methods for their use in aerosolizers|
|US7040549||21 Mar 2003||9 May 2006||Aerogen, Inc.||Systems and methods for controlling fluid feed to an aerosol generator|
|US7066398||30 Mar 2001||27 Jun 2006||Aerogen, Inc.||Aperture plate and methods for its construction and use|
|US7083112||6 Jun 2005||1 Ago 2006||Aerogen, Inc.||Method and apparatus for dispensing liquids as an atomized spray|
|US7100600||20 Mar 2001||5 Sep 2006||Aerogen, Inc.||Fluid filled ampoules and methods for their use in aerosolizers|
|US7104463||6 Oct 2005||12 Sep 2006||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US7108197 *||9 May 2005||19 Sep 2006||Aerogen, Inc.||Droplet ejector with oscillating tapered aperture|
|US7174888||5 Sep 2003||13 Feb 2007||Aerogen, Inc.||Liquid dispensing apparatus and methods|
|US7195011||30 Jun 2004||27 Mar 2007||Aerogen, Inc.||Convertible fluid feed system with comformable reservoir and methods|
|US7201167||14 Mar 2005||10 Abr 2007||Aerogen, Inc.||Method and composition for the treatment of lung surfactant deficiency or dysfunction|
|US7267121||30 Sep 2004||11 Sep 2007||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US7290541||30 Jun 2004||6 Nov 2007||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US7322349||18 Jun 2003||29 Ene 2008||Aerogen, Inc.||Apparatus and methods for the delivery of medicaments to the respiratory system|
|US7329430||9 Jul 2002||12 Feb 2008||Astrazeneca Ab||Method and device for coating pharmaceutical products|
|US7331339||23 Nov 2004||19 Feb 2008||Aerogen, Inc.||Methods and systems for operating an aerosol generator|
|US7360536||7 Ene 2003||22 Abr 2008||Aerogen, Inc.||Devices and methods for nebulizing fluids for inhalation|
|US7387038 *||29 Jul 2005||17 Jun 2008||Horiba Instruments, Inc.||Wide range constant concentration particle generating system|
|US7575761||8 Dic 2000||18 Ago 2009||Novartis Pharma Ag||Spray drying process control of drying kinetics|
|US7584903 *||4 Feb 2005||8 Sep 2009||Ing. Erich Pfeiffer Gmbh||Microdosing device|
|US7600511||30 Oct 2002||13 Oct 2009||Novartis Pharma Ag||Apparatus and methods for delivery of medicament to a respiratory system|
|US7628339||5 May 2006||8 Dic 2009||Novartis Pharma Ag||Systems and methods for controlling fluid feed to an aerosol generator|
|US7677467||20 Abr 2005||16 Mar 2010||Novartis Pharma Ag||Methods and devices for aerosolizing medicament|
|US7748377||30 Oct 2007||6 Jul 2010||Novartis Ag||Methods and systems for operating an aerosol generator|
|US7771642||1 Abr 2005||10 Ago 2010||Novartis Ag||Methods of making an apparatus for providing aerosol for medical treatment|
|US7931212 *||31 Jul 2003||26 Abr 2011||Pari Pharma Gmbh||Fluid droplet production apparatus and method|
|US7946291||20 Abr 2004||24 May 2011||Novartis Ag||Ventilation systems and methods employing aerosol generators|
|US7967221||16 Dic 2003||28 Jun 2011||Novartis Ag||Prefilming atomizer|
|US7971588||24 Mar 2005||5 Jul 2011||Novartis Ag||Methods and systems for operating an aerosol generator|
|US8173168||28 Sep 2006||8 May 2012||Novartis Pharma Ag||Dispersible macromolecule compositions and methods for their preparation and use|
|US8196573||23 Ene 2008||12 Jun 2012||Novartis Ag||Methods and systems for operating an aerosol generator|
|US8273330||24 Abr 2003||25 Sep 2012||Nektar Therapeutics||Particulate materials|
|US8336545||16 Ene 2007||25 Dic 2012||Novartis Pharma Ag||Methods and systems for operating an aerosol generator|
|US8337895||29 Jul 2009||25 Dic 2012||Novartis Ag||Spray drying process control of drying kinetics|
|US8348177||15 Jun 2009||8 Ene 2013||Davicon Corporation||Liquid dispensing apparatus using a passive liquid metering method|
|US8371290 *||9 Oct 2008||12 Feb 2013||General Electric Company||Device for delivery and regulation of volatile fluids into inspiratory gas|
|US8398001||19 Jun 2006||19 Mar 2013||Novartis Ag||Aperture plate and methods for its construction and use|
|US8511581||8 Mar 2011||20 Ago 2013||Pari Pharma Gmbh||Fluid droplet production apparatus and method|
|US8524279||31 Oct 2002||3 Sep 2013||Novartis Ag||Spray drying methods and related compositions|
|US8539944||8 Abr 2008||24 Sep 2013||Novartis Ag||Devices and methods for nebulizing fluids for inhalation|
|US8561604||12 Feb 2007||22 Oct 2013||Novartis Ag||Liquid dispensing apparatus and methods|
|US8578931||18 Abr 2000||12 Nov 2013||Novartis Ag||Methods and apparatus for storing chemical compounds in a portable inhaler|
|US8616195||27 Abr 2004||31 Dic 2013||Novartis Ag||Nebuliser for the production of aerosolized medication|
|US8616464||8 Jun 2011||31 Dic 2013||Novartis Ag||Prefilming atomizer|
|US8691022||18 Dic 2012||8 Abr 2014||Lam Research Ag||Method and apparatus for processing wafer-shaped articles|
|US8802149||20 May 2009||12 Ago 2014||Novartis Pharma Ag||Systems and processes for spray drying hydrophobic and hydrophilic components|
|US8936813||21 Oct 2011||20 Ene 2015||Novartis Ag||Spray drying methods and related compositions|
|US9028131 *||5 Oct 2011||12 May 2015||Universiti Putra Malaysia||Method and apparatus for high intensity ultrasonic treatment of baking materials|
|US9108211 *||17 Abr 2006||18 Ago 2015||Nektar Therapeutics||Vibration systems and methods|
|US20010013554 *||30 Mar 2001||16 Ago 2001||Scott Borland||Aperture plate and methods for its construction and use|
|US20020071871 *||31 Jul 2001||13 Jun 2002||Herm Snyder||Apparatus and process to produce particles having a narrow size distribution and particles made thereby|
|US20030044460 *||8 Dic 2000||6 Mar 2003||Bennett David B.||Spray drying process control of drying kinetics|
|US20030124193 *||31 Oct 2002||3 Jul 2003||Inhale Therapeutic System, Inc.||Spray drying methods and related compositions|
|US20030150445 *||30 Oct 2002||14 Ago 2003||Aerogen, Inc.||Apparatus and methods for delivery of medicament to a respiratory system|
|US20030232020 *||24 Abr 2003||18 Dic 2003||Peter York||Particulate materials|
|US20040004133 *||21 Mar 2003||8 Ene 2004||Aerogen, Inc.||Systems and methods for controlling fluid feed to an aerosol generator|
|US20040018696 *||31 Mar 2003||29 Ene 2004||Karsten Wieczorek||Method of filling an opening in a material layer with an insulating material|
|US20040035490 *||18 Jun 2003||26 Feb 2004||Aerogen, Inc.||Apparatus and methods for the delivery of medicaments to the respiratory system|
|US20040139968 *||5 Ene 2004||22 Jul 2004||Aerogen, Inc.||Fluid filled ampoules and methods for their use in aerosolizers|
|US20040140374 *||16 Dic 2003||22 Jul 2004||Nektar Therapeutics||Prefilming atomizer|
|US20040188534 *||9 Abr 2004||30 Sep 2004||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US20040247776 *||9 Jul 2002||9 Dic 2004||Staffan Folestad||Method and device for coating pharmaceutical products|
|US20040256488 *||30 Jun 2004||23 Dic 2004||Aerogen, Inc.||Convertible fluid feed system with comformable reservoir and methods|
|US20050011514 *||27 Abr 2004||20 Ene 2005||Aerogen, Inc.||Nebuliser for the production of aerosolized medication|
|US20050172954 *||23 Nov 2004||11 Ago 2005||Aerogen Inc.||Methods and systems for operating an aerosol generator|
|US20050178847 *||1 Abr 2005||18 Ago 2005||Aerogen, Inc.||Methods of making an apparatus for providing aerosol for medical treatment|
|US20050199236 *||20 Abr 2005||15 Sep 2005||Aerogen, Inc.||Methods and devices for aerosolizing medicament|
|US20050205089 *||19 Ene 2005||22 Sep 2005||Aerogen, Inc.||Methods and devices for aerosolizing medicament|
|US20050207917 *||4 Feb 2005||22 Sep 2005||Joachim Koerner||Microdosing device|
|US20050217666 *||24 Mar 2005||6 Oct 2005||Aerogen, Inc.||Methods and systems for operating an aerosol generator|
|US20050229926 *||14 Mar 2005||20 Oct 2005||Aerogen, Inc.||Method and composition for the treatment of lung surfactant deficiency or dysfunction|
|US20050229928 *||30 Jun 2004||20 Oct 2005||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US20050263608 *||9 May 2005||1 Dic 2005||Aerogen, Inc.||Droplet ejector with oscillating tapered aperture|
|US20050279851 *||6 Jun 2005||22 Dic 2005||Aerogen, Inc.||Method and apparatus for dispensing liquids as an atomized spray|
|US20060011737 *||11 Feb 2003||19 Ene 2006||Sara Lee/De B.V.||Liquid spray head, apparatus comprising a liquid spray-head and container therefore|
|US20060097068 *||31 Jul 2003||11 May 2006||Markus Urich||Fluid droplet production apparatus and method|
|US20070020199 *||28 Sep 2006||25 Ene 2007||Platz Robert M||Dispersible macromolecule compositions and methods for their preparation and use|
|US20070023547 *||19 Jun 2006||1 Feb 2007||Aerogen, Inc.||Aperture plate and methods for its construction and use|
|US20070028662 *||29 Jul 2005||8 Feb 2007||Qiang Wei||Wide range constant concentration particle generating system|
|US20070044792 *||30 Ago 2005||1 Mar 2007||Aerogen, Inc.||Aerosol generators with enhanced corrosion resistance|
|US20070075161 *||18 Sep 2006||5 Abr 2007||Aerogen, Inc.||Droplet Ejector With Oscillating Tapered Aperture|
|US20070209659 *||12 Feb 2007||13 Sep 2007||Aerogen, Inc.||Liquid dispensing apparatus and methods|
|US20070267010 *||16 Ene 2007||22 Nov 2007||Fink James B||Methods and systems for operating an aerosol generator|
|US20080017198 *||6 Ago 2007||24 Ene 2008||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US20080142002 *||23 Ene 2008||19 Jun 2008||Aerogen, Inc.||Methods and Systems for Operating an Aerosol Generator|
|US20080149096 *||21 Dic 2007||26 Jun 2008||Aerogen, Inc.||Apparatus and Methods for the Delivery of Medicaments to the Respiratory System|
|US20090095288 *||9 Oct 2008||16 Abr 2009||Haveri Heikki Antti Mikael||Device for delivery and regulation of volatile fluids into inspiratory gas|
|US20090134235 *||17 Abr 2006||28 May 2009||Aerogen, Inc.||Vibration Systems and Methods|
|US20090285905 *||20 May 2009||19 Nov 2009||Gordon Marc S||Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients|
|US20090308945 *||15 Jun 2009||17 Dic 2009||Jacob Loverich||Liquid dispensing apparatus using a passive liquid metering method|
|US20100034910 *||29 Jul 2009||11 Feb 2010||Novartis Pharma Ag||Spray drying process control of drying kinetics|
|US20110155768 *||8 Mar 2011||30 Jun 2011||Pari Pharma Gmbh||Fluid droplet production apparatus and method|
|US20130189407 *||5 Oct 2011||25 Jul 2013||Universiti Putra Malaysia||Method and apparatus for high intensity ultrasonic treatment of baking materials|
|CN100406134C||11 Feb 2003||30 Jul 2008||莎拉李公司||Liquid spray head and apparatus comprising the spray head and container|
|CN100406135C||9 Jul 2002||30 Jul 2008||阿斯特拉曾尼卡有限公司||Method and device for coating pharmaceutical products|
|EP0432992B1 *||10 Dic 1990||25 Ago 1993||Bespak plc||Dispensing apparatus|
|EP0762211A1 *||29 Ago 1996||12 Mar 1997||Hoechst Aktiengesellschaft||Matted radiation-sensitive recording material and process for its production|
|WO1994009912A1 *||25 Oct 1993||11 May 1994||Bespak Plc||Dispensing apparatus|
|WO1995025601A1 *||16 Mar 1995||28 Sep 1995||Siemens Aktiengesellschaft||Fluid dosing and spraying device|
|WO2000058022A1 *||23 Mar 2000||5 Oct 2000||Liposol Ltd.||A method and apparatus for nebulizing a liquid particularly useful for the aerosol delivery of biopharmaceuticals|
|WO2003006177A1 *||9 Jul 2002||23 Ene 2003||Astrazeneca Ab||Method and device for coating pharmaceutical products|
|WO2003068412A1 *||11 Feb 2002||21 Ago 2003||Sara Lee/De N.V.||Liquid spray-head, apparatus comprising a liquid spray-head and container therefore|
|WO2015091171A1 *||11 Dic 2014||25 Jun 2015||Koninklijke Philips N.V.||An assembly for use in liquid a droplet apparatus|
|WO2015091227A1 *||12 Dic 2014||25 Jun 2015||Koninklijke Philips N.V.||An assembly for use in a liquid droplet apparatus|
|Clasificación de EE.UU.||239/3, 366/127, 239/8, 366/176.1, 239/102.2, 239/4, 366/115|
|Clasificación internacional||B05B17/06, B05B7/04, B05B17/04|