|Número de publicación||US3794041 A|
|Tipo de publicación||Concesión|
|Fecha de publicación||26 Feb 1974|
|Fecha de presentación||30 Nov 1971|
|Fecha de prioridad||30 Nov 1971|
|Número de publicación||US 3794041 A, US 3794041A, US-A-3794041, US3794041 A, US3794041A|
|Inventores||Frei E, Yerushalmi S|
|Cesionario original||Yeda Res & Dev|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (5), Otras citas (1), Citada por (121), Clasificaciones (6)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
United States Patent [191 Frei et a1.
[ Feb. 26, 1974 GASTROINTESTINAL CATHETER  Inventors: Ephraim H. Frei; Shmuel Yerushalmi, both of Rehovot, Israel  Assignee: Yeda Research and Development Co.
Ltd., Rehovot, Israel 22 Filed: Nov. 30, 1971 21 App]. No.: 203,138
 US. Cl. 128/348, l28/l.3, 128/2 M  Int. Cl A6lm 25/00  Field of Search. 128/2 M, 205 R, 1.3, 1.4, 4-6, 128/7, 8, 303 R, 348, 349 R, 350 R, 356;
 References Cited UNITED STATES PATENTS 3,674,014 7/1972 Tillander 128/348 X 3,043,309 7/1962 McCarthy 128/348 2,863,458 12/1958 Modny et al 128/303 R 3,206,657 9/1965 Moriya 335/303 FOREIGN PATENTS OR APPLICATIONS 1,261,276 2/1968 Germany 128/6 OTHER PUBLICATIONS Frei et al., Med. Res. Engr. Fourth Quar. 1966, pp. 1 l-l 8 Primary Examiner-Dalton L. Truluck  ABSTRACT A gastrointestinal catheter of elongated shape, flexible and including ferromagnetic material enabling it, when inserted into the cavity of a body part, to be attracted by a magnet external of the body in order to manipulate the body part with the catheter. In the described embodiments, the ferromagnetic material is in the form of beads enclosed within a tube of inert resilient material, or strung on a string and coated with inert material.
2 Claims, 3 Drawing Figures GASTROINTESTINAL CATHETER BACKGROUND OF THE INVENTION The present invention relates to catheters insertable into a body cavity, and particularly to gastrointestinal catheters for insertion into a part of the intestinal tract, such as the intestines.
In certain types of disease, the only effective treatment consists of massive irradiation of the afflicted organ. This applies to many cases of carcinoma of the cervix, of the bladder, of the ovary and of the uterus, and also in similar diseases. One of the most serious problems of such treatment is the high sensitivity of the intestines to radiation damage, which seems to be due to the continuous shedding by the small bowel cells of its lining, and to the considerable mitotic activity of this organ.
BRIEF SUMMARY OF THE INVENTION In order to make possible a massive irradiation of the afflicted organs, while at the same time avoiding excessive irradiation of the radiation-sensitive intestines, and especially the small bowel, means are provided according to the present invention for moving the intestines out of the path of the radiation when same is used for irradiating the afflicted organs. The device according to the invention is a special catheter which is inserted into the intestines before the radiation treatment, which can be left in place for some time in this position, and which makes it possible to move the intestine out of the path of the irradiating beam.
The novel catheter made in accordance with the invention is flexible and of elongated shape, and includes ferromagnetic material enabling it, when inserted into the cavity of the body part, such as the intestine, to be attracted by a magnet external of the body, in order to manipulate the catheter and the body part therewith.
Preferably, the ferromagnetic material is in the form of beads.
In one described embodiment, the ferromagnetic beads are enclosed within a tube of inert resilient material, and in another described embodiment they are strung on a flexible core, such as string, the beads being coated with inert material.
Further features and advantageous of the invention will be apparent from the description below.
BRIEF DESCRIPTION OF THE DRAWINGS The invention is herewith described, by way of example only, with reference to the accompanying drawings, wherein:
FIG. 1 is a longitudinal sectional view of a part of a catheter constructed in accordance with the invention;
FIG. 2 illustrates a variation in the catheter construction of FIG. 1; and
FIG. 3 illustrates another form of catheter constructed in accordance with the invention.
DESCRIPTION OF THE PREFERRED EMBODIMENTS FIG. 1 illustrates a catheter particularly for insertion into the intestines for moving the intestines out of the path of radiation when the same is used for irradiating an afflicted organ The catheter of FIG. 1 includes. a hollow tube 2 of inert resilient material and a plurality of members or beads 4 of iron or other ferromagnetic material.
The length of the catheter is about one to several meters, and its diameter is between 3 to 8 mm. The tubing 2 is of a biologically acceptable material of adequate resilience, such as latex, silicon rubber or the like, of adequate wall-thickness to provide some degree of rigidity, yet supple enough to make it possible to follow the turns and bends of the intestines when inserted in same. A wall thickness of about 0.3 mm to L0 mm has proved satisfactory both for silicon rubber and for natural latex tubing.
Within the tubing there is provided the plurality of spherical or ellipsoid ferromagnetic beads 4 adapted to be strongly attracted by a magnet. The outer diameter of these beadsis chosen in such manner that they are held in place by the resiliency of the tube 2. It has been found that best results are obtained with oblong, ellipsoidal beads having a ratio of radii of about 1:2.
The ratio of magnetisation to the magnetic field applied shows that for prolate ellipsoids the best results are at a ratio of 1:2, as indicated above. With ellipsoids of very elongated shape there is a substantial torque, and this is a drawback for the intended use. No problem of torque exists of course with spherical beads.
Very good results were obtained with iron ellipsoids of a ratio of radii of about 1:2 of about 5 mm small diameter, inserted in a tube of 7 mm outer diameter, of 1 mm wall-thickness, and of 2 meter length.
According to a further embodiment of the invention as shown in FIG. 2; the external tube 12 includes a sequence of such iron beads 14 alternating with beads 16 of similar shape but of plastic material. The beads are positioned close to each other in the tube and some space is left if desired between the beads in order to facilitate the bending of the tube. It is of course possible to use any desired sequence of ferromagnetic beads 14 and of plastic beads 16, and also to use such beads of slightly different radius or shape.
According to a further embodiment of the invention as illustrated in FIG. 3, the catheter comprises a plurality of ferromagnetic beads 24 (if desired in a sequence with beads of plastic material) of spherical or ellipsoid shape strung on a suitable core 28 of string of adequate strength. Core 28 may also be a rod or hollow member of plastic or the like of small diameter. The most simple, yet satisfactory material for the spherical or ellipsoid beads is soft iron, and this is advantageously coated with a coating of plastic material 30 which is inert towards the environment of the gastrointestinal tract and which is biologically acceptable. The plastic coating 30 also reduces or eliminates the danger due to secondary radiation which may result from the incidence of primary radiation on the ferromagnetic beads, if the catheter or part of it remains in the path of the primary radiation used for the treatment of the patient.
The foregoing constructions provide an optimum of flexibility, while at the same time avoiding a bunching together of several members of the chain-like structure, either due to the peristaltic movement or due to the combination of the peristaltic movement together with the influence of the external magnetic force used to move the part of the intestine into which the catheter is inserted from the path of the radiation used for treatment.
First experiments were made by the direct introduction of ferrite powder into the intestines of a dog. This experiment proved that it is feasible to move the intestines by the application of an external magnetic field on the ferrite contained in same. The loops of the intestines could thus be moved sufficiently for the intended results.
After having proved the feasibility of such movement, experiments were continued with gastrointestinal catheters made of ferromagnetic beads. In animal experiments the catheter was inserted and soft X-rays to about 40 KV were used for monitoring the movement of the intestinal loops due to the application of an external magnetic field on such catheter. With guinea pigs a loop of the intestine was moved by means of an external horseshoe magnet and pulled towards the magnet in such manner that the external skin was raised appreciably and pulled into the gap of the horseshoe magnet. The animal was drugged and maintained in this position for hours after which the magnet and the catheter were removed. Histological examination showed no damage to the intestinal tissue. The natural movement of the material in the intestines was not affected by the presence of the catheter.
Further experiments were carried out with dogs. A catheter according to FIG. 1 and comprising a plurality of iron beads of ellipsoidal shape of 1:2 ratio of radii of 3 mm diameter (small radius) in a silicon rubber tubing of 0.6 mm wall thickness was inserted through the mouth or via a small incision made in the small intestine. When a magnetic field was applied from the outside of the body by means of a magnet having a field strength of 6,000 oersted at the face of the magnet, with a 2-inch iron core diameter, this moved the catheter together with the intestine for a sufficient distance.
Similar experiments were made with the FIG. 3 form of the catheter, consisting of a plurality of plasticcoated iron ellipsoids strung on a suitable string, and satisfactory results were obtained.
A number of experiments were carried out with humans. A gastrointestinal catheter according to the FIG. 1 form of 1 meter length and 3-7 mm outer diameter of the tubing ensheathing the iron beads, was inserted into the intestines. The application of a magnetic field from outside the body, of about 6 K-oersted moved the catheter and the loop of the intestine in the desired direction.
In the FIG. 3 form, the provision of a coating 30 of plastic, such as polyethylene or the like, of adequate thickness, on the iron beads prevents any secondary radiation from damaging the intestines, if the catheter is in part in the path of the radiation used for the treatment. In practice it is advisable to examine the patient by X-rays prior to the radiation treatment in order to ascertain that the loop or loops of the intestine, together with the catheter inserted thereinto, have been moved away.
In guinea pig experiments Alnico 5 magnets were used as the external magnets for attracting the catheter and the body part therein. With humans it is advisable to use superconducting magnets of great field strength and comparatively small size.
Catheters of about 4-7 mm outer diameter may be left in the intestines for quite prolonged periods without any adverse effect. Examinations carried out after 10 days showed that no damage was caused by the catheter and that it did not interfere with the natural body activities. During such prolonged periods it is possible to carry out an intensive radiation treatment.
It is clear that the above description is by way of example only and that many modifications, changes and other applications of the catheters described may be made.
What is claimed is:
1. Magnetic apparatus insertable into a body cavity, for displacement of internal body organs from a region of applied radiation by means of a magnet disposed externally of the body, characterized in that it is of elongated shape, flexible and includes an elongated flexible tubular member of substantially inert resilient biologically acceptable material;
a plurality of ellipsoidal beads of soft iron having major and minor axes substantially in a 2:1 ratio respectively, axially disposed with their major axes parallel to the longitudinal axis of said tubular member and in closely adjacent spaced relationship therein over a substantial length thereof, said soft iron ellipsoidal beads being fixed in said spaced relationship by said resiliency of said flexible tubular member;
said magnetic apparatus being adapted when inserted into the cavity of a body part, to be uniformly and unidirectionally attracted by a magnet external of the body for desired displacement of said body part as aforesaid substantially without the application of torque to said beads.
2. Magnetic apparatus insertable into a body cavity, for displacement of internal body organs as defined in claim 1, wherein said flexible tubular member also includes plastic beads alternating with and spaced from said soft iron beads and similarly fixed in said spaced relationship by said resiliency of said flexible tubular member.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US2863458 *||4 Sep 1957||9 Dic 1958||Bambara John P||Vein stripper and a method of stripping veins|
|US3043309 *||29 Sep 1959||10 Jul 1962||Avco Corp||Method of performing intestinal intubation|
|US3206657 *||4 Abr 1961||14 Sep 1965||Moriya Saburo Miyata||Magnet assembly for filtering|
|US3674014 *||21 Oct 1970||4 Jul 1972||Astra Meditec Ab||Magnetically guidable catheter-tip and method|
|DE1261276B *||21 Jul 1965||15 Feb 1968||Storz Karl||Vorrichtung zur Lenkung eines biegsamen Schaftes, insbesondere eines Endoskopschaftes in Koerperhoehlen|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3941119 *||19 Jul 1974||2 Mar 1976||Mario Corrales||Means for introducing and guiding objects into body cavities and blood vessels|
|US3961632 *||13 Dic 1974||8 Jun 1976||Moossun Mohamed H||Stomach intubation and catheter placement system|
|US4005699 *||9 Oct 1974||1 Feb 1977||Louis Bucalo||Methods and apparatus for use in magnetic treatment of the body|
|US4024855 *||18 Nov 1975||24 May 1977||Louis Bucalo||Magnetic filamentary structure and method for using the same|
|US4063561 *||20 Sep 1976||20 Dic 1977||The Signal Companies, Inc.||Direction control device for endotracheal tube|
|US4111190 *||11 Nov 1976||5 Sep 1978||Jane Plumridge||Medical applicator assembly for chain cystourethrographic procedure|
|US4197840 *||29 Sep 1976||15 Abr 1980||Bbc Brown Boveri & Company, Limited||Permanent magnet device for implantation|
|US4197846 *||25 Jun 1975||15 Abr 1980||Louis Bucalo||Method for structure for situating in a living body agents for treating the body|
|US4294260 *||18 Jun 1979||13 Oct 1981||Olympia Radiological Associates||Cystourethrographic examination chain|
|US4303062 *||9 Jul 1980||1 Dic 1981||Intervet, Inc.||Therapeutic magnet|
|US4364377 *||2 Feb 1981||21 Dic 1982||Walker Scientific, Inc.||Magnetic field hemostasis|
|US4410320 *||28 Ago 1981||18 Oct 1983||Ethox Corp.||Weighted enteric feeding tube|
|US4545081 *||12 Mar 1984||8 Oct 1985||Jack Nestor||Semi-rigid penile prosthesis with separable members and posture control|
|US4809713 *||28 Oct 1987||7 Mar 1989||Joseph Grayzel||Catheter with magnetic fixation|
|US5042475 *||8 Mar 1990||27 Ago 1991||Portex, Inc.||Hinged tracheostomy tube obturator|
|US5125888 *||10 Ene 1990||30 Jun 1992||University Of Virginia Alumni Patents Foundation||Magnetic stereotactic system for treatment delivery|
|US5222487 *||21 Jun 1991||29 Jun 1993||Smiths Industries Medical Systems, Inc.||Hinged tracheostomy tube obturator|
|US5361754 *||25 Ene 1993||8 Nov 1994||Mallinckrodt Medical, Inc.||Apparatus and method for connecting a tracheostomy tube to a neckplate|
|US5415165 *||16 Ago 1994||16 May 1995||Mountpelier Investments||Tonometric catheter combination|
|US5429131 *||25 Feb 1994||4 Jul 1995||The Regents Of The University Of California||Magnetized electrode tip catheter|
|US5431640 *||9 Nov 1994||11 Jul 1995||The Medical Center Of Central Georgia||Method and apparatus for duodenal intubation of a patient|
|US5433216 *||14 Jun 1993||18 Jul 1995||Mountpelier Investments, S.A.||Intra-abdominal pressure measurement apparatus and method|
|US5443478 *||2 Sep 1992||22 Ago 1995||Board Of Regents, The University Of Texas System||Multi-element intravascular occlusion device|
|US5456251 *||12 Oct 1994||10 Oct 1995||Mountpelier Investments, S.A.||Remote sensing tonometric catheter apparatus and method|
|US5526809 *||19 May 1995||18 Jun 1996||Mountpelier Investments, S.A.||Hollow viscous and soild organ tonometry|
|US5527338 *||9 Dic 1993||18 Jun 1996||Board Of Regents, The University Of Texas System||Intravascular device|
|US5529568 *||18 Mar 1994||25 Jun 1996||Surgery Futures Research, Inc.||Magnetic operating table|
|US5546937 *||13 Dic 1993||20 Ago 1996||Stuart; J. Michael||Obturator and tracheostomy tube containing the obturator|
|US5593379 *||5 Jun 1995||14 Ene 1997||Surgery Futures Research, Inc.||Magnetic operating table|
|US5645065 *||11 Abr 1995||8 Jul 1997||Navion Biomedical Corporation||Catheter depth, position and orientation location system|
|US5693067 *||12 Jun 1996||2 Dic 1997||Board Of Regents, The University Of Texas System||Intravascular device|
|US5778877 *||5 Jun 1995||14 Jul 1998||Mallinckrodt Medical, Inc.||Apparatus and method for connecting a tracheostomy tube to a neckplate|
|US5779694 *||19 Jul 1993||14 Jul 1998||The University Of Virginia Alumni Patents Foundation||Magnetic stereotactic system for treatment delivery|
|US5788631 *||29 Feb 1996||4 Ago 1998||Instrumentarium Corporation||Hollow viscus and solid organ tonometry|
|US5851218 *||2 Ene 1997||22 Dic 1998||Lev; Shlomo||Annular catheter method of assembling and method of using the same|
|US5925062 *||26 Sep 1997||20 Jul 1999||Board Of Regents, The University Of Texas System||Intravascular device|
|US5951566 *||28 Feb 1997||14 Sep 1999||Lev; Shlomo||Annular catheter|
|US5989225 *||19 Mar 1997||23 Nov 1999||Sherwood Services Ag||Gastrointestinal-type tube insertion or removal device|
|US6010453 *||12 May 1995||4 Ene 2000||Instrumentarium Corporation||Tonometric catheter combination|
|US6045536 *||24 Feb 1999||4 Abr 2000||Sherwood Services, A.G.||Securing device for a low profile gastrostomy tube|
|US6146396 *||5 Mar 1999||14 Nov 2000||Board Of Regents, The University Of Texas System||Declotting method and apparatus|
|US6216030||13 Jul 1998||10 Abr 2001||The University Of Virginia Alumni Patents Foundation||Magnetic stereotactic system for treatment delivery|
|US6273904||2 Mar 1999||14 Ago 2001||Light Sciences Corporation||Polymer battery for internal light device|
|US6334064||26 May 1995||25 Dic 2001||Instrumentarium Corp.||Remote sensing tonometric catheter apparatus and method|
|US6368338||5 Mar 1999||9 Abr 2002||Board Of Regents, The University Of Texas||Occlusion method and apparatus|
|US6542766 *||19 Jul 2001||1 Abr 2003||Andrew F. Hall||Medical devices adapted for magnetic navigation with magnetic fields and gradients|
|US6894456||5 Dic 2002||17 May 2005||Quallion Llc||Implantable medical power module|
|US6994717||9 Abr 2002||7 Feb 2006||Board Of Regents, The University Of Texas Systems||Occlusion method and apparatus|
|US7003356||17 Abr 2002||21 Feb 2006||Quallion Llc||Battery terminal sealing and supporting device and method|
|US7009362||19 Nov 2003||7 Mar 2006||Quallion Llc||Standalone implantable medical power module|
|US7010338||6 Ene 2003||7 Mar 2006||Stereotaxis, Inc.||Device for locating magnetic implant by source field|
|US7166127||24 Sep 2004||23 Ene 2007||Mitralign, Inc.||Tissue fastening systems and methods utilizing magnetic guidance|
|US7431726||24 Sep 2004||7 Oct 2008||Mitralign, Inc.||Tissue fastening systems and methods utilizing magnetic guidance|
|US7486048||29 Jul 2004||3 Feb 2009||Quallion Llc||Implantable power module for powering a medical device|
|US7744596 *||13 Oct 2005||29 Jun 2010||Boston Scientific Scimed, Inc.||Magnetically augmented radio frequency ablation|
|US7976518||13 Ene 2005||12 Jul 2011||Corpak Medsystems, Inc.||Tubing assembly and signal generator placement control device and method for use with catheter guidance systems|
|US7993285 *||5 Nov 2002||9 Ago 2011||Boston Scientific Scimed, Inc.||Medical device having flexible distal tip|
|US8142493||22 Jul 2008||27 Mar 2012||Mitralign, Inc.||Method of heart valve repair|
|US8197494||8 Sep 2006||12 Jun 2012||Corpak Medsystems, Inc.||Medical device position guidance system with wireless connectivity between a noninvasive device and an invasive device|
|US8460371||21 Oct 2003||11 Jun 2013||Mitralign, Inc.||Method and apparatus for performing catheter-based annuloplasty using local plications|
|US8845723||13 Mar 2007||30 Sep 2014||Mitralign, Inc.||Systems and methods for introducing elements into tissue|
|US8864822||13 Mar 2007||21 Oct 2014||Mitralign, Inc.||Devices and methods for introducing elements into tissue|
|US8911461||5 Nov 2007||16 Dic 2014||Mitralign, Inc.||Suture cutter and method of cutting suture|
|US8951285||5 Jul 2005||10 Feb 2015||Mitralign, Inc.||Tissue anchor, anchoring system and methods of using the same|
|US8951286||19 Nov 2008||10 Feb 2015||Mitralign, Inc.||Tissue anchor and anchoring system|
|US8979923||24 Sep 2004||17 Mar 2015||Mitralign, Inc.||Tissue fastening systems and methods utilizing magnetic guidance|
|US9028441||7 Sep 2012||12 May 2015||Corpak Medsystems, Inc.||Apparatus and method used with guidance system for feeding and suctioning|
|US9131956||2 Jun 2011||15 Sep 2015||Corpak Medsystems, Inc.||Tubing assembly and signal generator placement control device and method for use with catheter guidance systems|
|US9149740||1 Dic 2011||6 Oct 2015||Adey Holdings (2008) Limited||Water and dirt separator|
|US9259218||26 Feb 2013||16 Feb 2016||Mitralign, Inc.||Tissue anchor and anchoring system|
|US9358111||27 Ago 2013||7 Jun 2016||Mitralign, Inc.||Tissue anchors, systems and methods, and devices|
|US9358112||19 Dic 2013||7 Jun 2016||Mitralign, Inc.||Method and apparatus for catheter-based annuloplasty using local plications|
|US9463471||1 Dic 2011||11 Oct 2016||Adey Holdings (2008) Limited||Water and dirt separator|
|US9579488||14 Sep 2015||28 Feb 2017||Corpak Medsystems, Inc.||Tubing assembly and signal generator placement control device and method for use with catheter guidance systems|
|US9687174||16 May 2012||27 Jun 2017||Corpak Medsystems, Inc.||Medical device position guidance system with wireless connectivity between a noninvasive and an invasive device|
|US9750608||18 Ago 2014||5 Sep 2017||Mitralign, Inc.||Systems and methods for introducing elements into tissue|
|US9814454||23 Dic 2014||14 Nov 2017||Mitralign, Inc.||Tissue anchor and anchoring system|
|US20020156499 *||9 Abr 2002||24 Oct 2002||Andras Konya||Occlusion method and apparatus|
|US20030153827 *||6 Ene 2003||14 Ago 2003||Ritter Rogers C.||Method and device for locating magnetic implant by source field|
|US20030171783 *||17 Abr 2002||11 Sep 2003||Quallion Llc||Battery terminal sealing and supporting device and method|
|US20040019378 *||18 Jul 2003||29 Ene 2004||Hlavka Edwin J.||Method and apparatus for performing catheter-based annuloplasty|
|US20040087876 *||5 Nov 2002||6 May 2004||Scimed Life Systems, Inc.||Medical device having flexible distal tip|
|US20040172046 *||21 Oct 2003||2 Sep 2004||Hlavka Edwin J.||Method and apparatus for performing catheter-based annuloplasty using local plications|
|US20050021100 *||29 Jul 2004||27 Ene 2005||Quallion Llc||Implantable medical power module|
|US20050119734 *||24 Sep 2004||2 Jun 2005||Spence Paul A.||Tissue fastening systems and methods utilizing magnetic guidance|
|US20050119735 *||24 Sep 2004||2 Jun 2005||Spence Paul A.||Tissue fastening systems and methods utilizing magnetic guidance|
|US20050125011 *||31 Ene 2005||9 Jun 2005||Spence Paul A.||Tissue fastening systems and methods utilizing magnetic guidance|
|US20050137700 *||24 Sep 2004||23 Jun 2005||Spence Paul A.||Tissue fastening systems and methods utilizing magnetic guidance|
|US20050184122 *||21 Abr 2005||25 Ago 2005||Mitralign, Inc.||Method and apparatus for performing catheter-based annuloplasty using local plications|
|US20050267571 *||24 Sep 2004||1 Dic 2005||Spence Paul A||Tissue fastening systems and methods utilizing magnetic guidance|
|US20060069429 *||24 Sep 2004||30 Mar 2006||Spence Paul A||Tissue fastening systems and methods utilizing magnetic guidance|
|US20060155303 *||6 Feb 2006||13 Jul 2006||Andras Konya||Occlusion method and apparatus|
|US20060173407 *||13 Ene 2005||3 Ago 2006||Shaughnessy Michael C|
|US20070010857 *||5 Jul 2005||11 Ene 2007||Mitralign, Inc.||Tissue anchor, anchoring system and methods of using the same|
|US20070021645 *||13 Jul 2004||25 Ene 2007||Joachim Zimmerman||Medical device|
|US20070038074 *||7 Mar 2006||15 Feb 2007||Ritter Rogers C||Method and device for locating magnetic implant source field|
|US20070080188 *||22 Jun 2006||12 Abr 2007||Mitralign, Inc.||Tissue fastening systems and methods|
|US20070112424 *||11 Ene 2007||17 May 2007||Mitralign, Inc.||Catheter based tissue fastening systems and methods|
|US20070135802 *||14 Dic 2005||14 Jun 2007||Olympus Medical Systems Corp.||Method of lifting diseased part, tissue lifting system, and indwelling tool|
|US20070197906 *||16 Ene 2007||23 Ago 2007||Ritter Rogers C||Magnetic field shape-adjustable medical device and method of using the same|
|US20080097475 *||8 Sep 2006||24 Abr 2008||Viasys Holdings, Inc.||Medical device position guidance system with wireless connectivity between a noninvasive device and an invasive device|
|US20080171907 *||12 Ene 2007||17 Jul 2008||Ethicon Endo-Surgery, Inc.||Magnetic Tissue Grasping|
|US20080228165 *||13 Mar 2007||18 Sep 2008||Mitralign, Inc.||Systems and methods for introducing elements into tissue|
|US20080228198 *||5 Nov 2007||18 Sep 2008||Mitralign, Inc.||Suture cutter and method of cutting suture|
|US20080228265 *||13 Mar 2007||18 Sep 2008||Mitralign, Inc.||Tissue anchors, systems and methods, and devices|
|US20080228267 *||13 Mar 2007||18 Sep 2008||Mitralign, Inc.||Devices and methods for introducing elements into tissue|
|US20090062772 *||29 Ago 2008||5 Mar 2009||Syncro Medical Innovations, Inc.||Guided catheter with removable magnetic guide|
|US20090076547 *||19 Nov 2008||19 Mar 2009||Mitralign, Inc.||Tissue anchor and anchoring system|
|US20100145147 *||2 Sep 2009||10 Jun 2010||Syncro Medical Innovations, Inc.||Magnetic device for guiding catheter and method of use therefor|
|USRE38972 *||19 Jul 2001||7 Feb 2006||Board Of Regents, The University Of Texas System||Intravascular device|
|USRE43030||27 Abr 2005||13 Dic 2011||Board Of Regents, The University Of Texas System||Intravascular device|
|DE4014947A1 *||10 May 1990||14 Nov 1991||Wolfgang Dr Med Ram||Flexible catheter for diagnostic or therapeutic purposes - has very small guiding magnet of high remanence at distal end and extra corporal control magnets|
|DE19733889A1 *||5 Ago 1997||11 Feb 1999||Kadalie Clemens Themba||Representation of organ systems during control and guidance of e.g. guide wires, probes, catheters and endoscopes|
|DE102010036806A1 *||2 Ago 2010||2 Feb 2012||Sun Lung Gear Works Co., Ltd.||Apparatus for magnetic cleaning of contaminated oil in e.g. gearbox, has handle comprising end connected with flexible disk-shaped or rod-shaped magnetic unit, where supporting element is provided at outer side of magnetic unit|
|EP0232968A2 *||9 Ene 1987||19 Ago 1987||Mountpelier Investments, S.A.||Apparatus for placement of and in combination with a pliable catheter|
|EP0232968A3 *||9 Ene 1987||15 Jun 1988||Richard G. Fiddian-Green||Apparatus and method for sustaining vitality of organs of the gastrointestinal tract|
|EP0773005A1||13 Nov 1995||14 May 1997||Surgery Futures Research Inc.||Magnetic operation table|
|WO1993000124A1 *||19 Jun 1992||7 Ene 1993||Smiths Industries Medical Systems, Inc.||A hinged tracheostomy tube obturator|
|WO1996032075A1 *||4 Abr 1996||17 Oct 1996||Iradj Hessabi||Device for aiding oral administration, especially to animals|
|WO1997034552A1 *||19 Mar 1997||25 Sep 1997||Sherwood Medical Company||Gastrointestinal-type tube insertion or removal device|
|WO1999056813A1||5 May 1998||11 Nov 1999||Sabry Gabriel||Method and apparatus for intubation of a patient|
|Clasificación de EE.UU.||606/108, 600/12|
|Clasificación internacional||A61M25/092, A61M25/01|