|
| US3948263 | 14 Ago 1974 | 6 Abr 1976 | Minnesota Mining and Manufacturing Company | Ballistic animal implant |
| US3976071 | 7 Ene 1974 | 24 Ago 1976 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
| US3991759 | 28 Oct 1975 | 16 Nov 1976 | Alza Corporation | Method and therapeutic system for treating aqueous deficient dry eye |
| US4008719 | 2 Feb 1976 | 22 Feb 1977 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4014334 | 2 Feb 1976 | 29 Mar 1977 | Alza Corporation | Laminated osmotic system for dispensing beneficial agent |
| US4058122 | 15 Dic 1976 | 15 Nov 1977 | Alza Corporation | Osmotic system with laminated wall formed of different materials |
| US4116241 | 15 Dic 1976 | 26 Sep 1978 | Alza Corporation | Osmotic system with laminated wall comprising structurally different semipermeable lamina |
| US4145320 | 1 Nov 1976 | 20 Mar 1979 | | Polymers containing polyunsaturated acid radicals, process for their preparation and use thereof |
| US4177256 | 29 Nov 1977 | 4 Dic 1979 | ALZA Corporation | Osmotic bursting drug delivery device |
| US4180064 | 15 Dic 1976 | 25 Dic 1979 | Alza Corporation | System for delivering agent to environment of use over prolonged time |
| US4228152 | 14 Nov 1978 | 14 Oct 1980 | | Polymers containing prostaglandin radicals, process for their preparation and use thereof |
| US4249531 | 5 Jul 1979 | 10 Feb 1981 | Alza Corporation | Bioerodible system for delivering drug manufactured from poly(carboxylic acid) |
| US4381772 | 20 Nov 1980 | 3 May 1983 | | Bioerodible diaphragm |
| US4454148 | 9 Dic 1982 | 12 Jun 1984 | Merck & Co., Inc. | 5-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure |
| US4484923 | 5 Ene 1984 | 27 Nov 1984 | ALZA Corporation | Method for administering immunopotentiator |
| US4668506 | 16 Ago 1985 | 26 May 1987 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
| US4685883 | 26 Jul 1985 | 11 Ago 1987 | | Local delivery of chemotherapeutic agents for the treatment of periodontal disease |
| US4713244 | 16 Ago 1985 | 15 Dic 1987 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C.sub.1 -C.sub.4) polar solvent |
| US4764380 | 13 Feb 1987 | 16 Ago 1988 | Alza Corporation | Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills |
| US4795436 | 22 Sep 1986 | 3 Ene 1989 | Bio-Mimetics, Inc. | Bioadhesive composition and method of treatment therewith |
| US4843112 | 12 Mar 1987 | 27 Jun 1989 | The Beth Israel Hospital Association | Bioerodable implant composition |
| US4851232 | 8 Jun 1987 | 25 Jul 1989 | Alza Corporation | Drug delivery system with means for obtaining desirable in vivo release rate pattern |
| US4886870 | 15 Feb 1985 | 12 Dic 1989 | Massachusetts Institute of Technology | Bioerodible articles useful as implants and prostheses having predictable degradation rates |
| US4891225 | 21 Ene 1986 | 2 Ene 1990 | Massachusetts Institute of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| US4906474 | 21 May 1984 | 6 Mar 1990 | Massachusetts Institute of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| US4946929 | 15 Jun 1987 | 7 Ago 1990 | Massachusetts Institute of Technology | Bioerodible articles useful as implants and prostheses having predictable degradation rates |
| US4983392 | 20 Dic 1988 | 8 Ene 1991 | Bio-Mimetics, Inc.
Columbia Laboratories, Inc. | Bioadhesive compositions and methods of treatment therewith |
| US5085861 | 12 May 1989 | 4 Feb 1992 | The Beth Israel Hospital Association | Bioerodable implant composition comprising crosslinked biodegradable polyesters |
| US5225196 | 7 Ene 1991 | 6 Jul 1993 | Columbia Laboratories, Inc. | Bioadhesive compositions and methods of treatment therewith |
| US5545409 | 5 Abr 1994 | 13 Ago 1996 | Massachusetts Institute of Technology | Delivery system for controlled release of bioactive factors |
| US5629009 | 7 Ago 1996 | 13 May 1997 | Massachusetts Institute of Technology | Delivery system for controlled release of bioactive factors |
| US5660851 | 5 Jun 1995 | 26 Ago 1997 | Yissum Research Development Company of the Hebrew Univ. of Jerusalem | Ocular inserts |
| US6034101 | 31 Jul 1997 | 7 Mar 2000 | ALZA Corporation | Dosage form and method for administering drug |
| US6123957 | 16 Jul 1997 | 26 Sep 2000 | | Delivery of agents and method for regeneration of periodontal tissues |
| US6262115 | 29 Mar 1999 | 17 Jul 2001 | ALZA Coporation | Method for the management of incontinence |
| US6833140 | 11 Jun 2002 | 21 Dic 2004 | Xenoport, Inc. | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
| US6919092 | 16 Feb 2001 | 19 Jul 2005 | ALZA Corporation | Method for the management of incontinence |
| US6919373 | 19 Feb 1999 | 19 Jul 2005 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
| US6930129 | 8 Mar 2001 | 16 Ago 2005 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
| US7101912 | 8 Dic 2003 | 5 Sep 2006 | XenoPort, Inc. | Carbidopa prodrugs and derivatives, and compositions and uses thereof |
| US7109239 | 20 Ago 2004 | 19 Sep 2006 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7208611 | 23 Feb 2006 | 24 Abr 2007 | XenoPort, Inc. | Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use |
| US7232924 | 11 Jun 2003 | 19 Jun 2007 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US7300956 | 21 Ago 2006 | 27 Nov 2007 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7323585 | 3 Jun 2005 | 29 Ene 2008 | XenoPort, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| US7342131 | 3 Jun 2005 | 11 Mar 2008 | XenoPort, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| US7351740 | 20 Jun 2006 | 1 Abr 2008 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use |
| US7420002 | 11 Jun 2002 | 2 Sep 2008 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
| US7423169 | 21 Ago 2006 | 9 Sep 2008 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US7494985 | 3 Nov 2005 | 24 Feb 2009 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| US7534813 | 10 Ene 2008 | 19 May 2009 | XenoPort, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| US7563821 | 4 Dic 2006 | 21 Jul 2009 | XenoPort, Inc. | Levodopa prodrug mesylate, compositions thereof, and uses thereof |
| US7566738 | 3 Nov 2005 | 28 Jul 2009 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
| US7572830 | 24 Oct 2007 | 11 Ago 2009 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7585996 | 13 Sep 2007 | 8 Sep 2009 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7592369 | 12 Oct 2007 | 22 Sep 2009 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use |
| US7645797 | 28 May 2008 | 12 Ene 2010 | XenoPort, Inc. | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
| US7671089 | 11 Dic 2007 | 2 Mar 2010 | XenoPort, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| US7700652 | 13 Sep 2004 | 20 Abr 2010 | XenoPort, Inc. | Treating urinary incontinence using prodrugs of GABA analogs |
| US7709527 | 20 Dic 2007 | 4 May 2010 | XenoPort, Inc. | Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use |
| US7749985 | 21 Jul 2009 | 6 Jul 2010 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7777070 | 14 Ago 2009 | 17 Ago 2010 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use |
| US7829592 | 20 Dic 2007 | 9 Nov 2010 | XenoPort, Inc. | Catechol protected levodopa diester prodrugs, compositions, and methods of use |
| US7893105 | 22 Jun 2009 | 22 Feb 2011 | XenoPort, Inc. | Levodopa prodrug mesylate, compositions thereof, and uses thereof |
| US7935686 | 14 Ene 2009 | 3 May 2011 | XenoPort, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| US7956212 | 2 Feb 2009 | 7 Jun 2011 | XenoPort, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| US7968597 | 31 Dic 2008 | 28 Jun 2011 | XenoPort, Inc. | Levodopa prodrug mesylate, compositions thereof, and uses thereof |
| US8084059 | 15 Sep 2006 | 27 Dic 2011 | ALZA Corporation | Antidepressant dosage form |
| US8114909 | 17 Sep 2004 | 14 Feb 2012 | XenoPort, Inc. | Treating or preventing restless legs syndrome using prodrugs of GABA analogs |
| US8163798 | 12 Ago 2003 | 24 Abr 2012 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
| US8163958 | 27 Abr 2011 | 24 Abr 2012 | Xenoport, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| US8193242 | 20 Ene 2011 | 5 Jun 2012 | XenoPort, Inc. | Levodopa prodrug mesylate, compositions thereof, and uses thereof |
| US8216603 | 4 May 2007 | 10 Jul 2012 | | Method, device, and system for delivery of therapeutic agents to the eye |
