US3812252A - Method of treating wounds with a medicinal dressing - Google Patents
Method of treating wounds with a medicinal dressing Download PDFInfo
- Publication number
- US3812252A US3812252A US00286741A US28674172A US3812252A US 3812252 A US3812252 A US 3812252A US 00286741 A US00286741 A US 00286741A US 28674172 A US28674172 A US 28674172A US 3812252 A US3812252 A US 3812252A
- Authority
- US
- United States
- Prior art keywords
- starch hydrolysate
- wound
- starch
- burn
- treated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/13—Burn treatment
Definitions
- This invention relates to the treatment of skin wounds; e.g., second and third degree burns, stasis ulcers, trophic lesions such as decubitus ulcers, severe cuts and abrasions, and more particularly to a method for treating burns and exudative lesions with a medicinal dressing.
- the aforementioned skin wounds are characterized by open wounds or gaps in the skin tissue. As the healing process progresses these open wounds are gradually filled in by new cells which appear across the surface of the open wound so that when the healing process is complete, new skin tissue covers the former open area of the wound. Such cells are termed granulation cells and the healing mechanism is a granulation cell formation process. These granulation cells are, however, very fragile and rupture easily. I-Ieretofore, conventional dry gauze dressings have been used widely on such burns or exudative lesions. When dry gauze is removed, as for example when it is changed, the cells rupture; thus temporarily arresting the healing process. A dressing for burns and exudative lesions, therefore, should be capable of removal without disturbing the growth of the very fragile granulation cells.
- a method for the treatment of the aforementioned skin wounds should, therefore, employ a dressing which is as close as functionally possible to a natural wound scab, be permeable to exudate but not to proteinaceous material, be flexible and not lift up, and inhibit the start or spread of secondary infections by reducing the bacteria count around the treated wound.
- the dressing employed should be similar to a skin autograft in that it affords a natural protective covering which promotes healing, and yet it should, like a homograft, be easily sloughed off by the body when the healing process is completed.
- Dextrose Equivalent is an expression in the art for describing the total reducing sugar content of a material calculated as dextrose, and expressed as per cent, dry basis. This value may be measured by any of the methods known in the art such as by the Luff- Schoorl Method (NBS Circular 0440), page as appearing infPolarimetry, Saccharimetry and the Sugars.. Authors: Frederick J. Bates and Assoc. A low.
- D.E. starch hydrolysate product is one having a DE. of less than about 35.
- a sterile, purified starch hydrolysate material having a D.E. of less than about 35
- the preferred sterile, purified starch hydrolysate materials have a D.E. of between about 5 and about 25.
- This material is water soluble so that it need not be mechanically removed from a wound; it can be washed away by flooding with water. When applied to an exudative skin wound as a dressing, this material dissolves slightly in the exudate to fonn a covering which is very similar to a natural wound scab. This covering has been found to be somewhat flexible so that some movement of the treated area is possible without causing the covering to lift up'and away from the exudative wound.
- the dressing also has been found to act as a semipermeable membrane which allows edemic liquids to pass through it while proteinaceous materials are retained within the bodyrThe exudate is clean and relatively free. of proteinaceous materials. It, therefore, does not support biological oxidation to the same extent as exudate containing proteinaceous fluids is minimized while at the same time excessive build up of edemic liquids is also minimized. The possibility of the patient going into shock is, therefore, greatly reduced.
- the sterile, purified starch hydrolysate particulate material having a DB. less than about 35 may be admixed with any of the antibacterial agents known to the art to be effective in the prevention or treatment of secondary infections, e. g., iodine, penicillin, nitrofuranes and the sulfa drugs such as silver sulfadiazine.
- proteolytic enzymes known by the art to be effective in promoting healing may also be admixed with this particulate material.
- nutritive agents such as the amino acids, cystine and cysteine, and vitamins, such as ascorbic acid (Vitamin C), may also be admixed or applied along with this particulate material to promote the formation and growth of healthy granulation tissue.
- vitamins such as ascorbic acid (Vitamin C)
- the sterile, purified starch hydrolysate material having a D.E. of less than about 35 can be applied as a particulate material such as a powder, or as a viscous material such as a gel, paste, dispersion, solution or syrup.
- a viscous starch hydrolysate can be made by adding the starch hydrolysate to a non-toxic, polar liquid vehicle or carrier such as water, glycerin, glycols or polyols.
- the low D.E., sterile, purified starch hydrolysate material may be applied directly to the wound or it may, to facilitate handling and storing, be applied to a bibulous backing, as for example a sterile gauze pad, and the bibulous backing then applied to the wound so that the starch hydrolysate material comes into contact with the skin wound.
- Starch hydrolysate materials for use in practicing the present invention are those having a D.E. of less than about 35, and preferably from about 5 to about 25. These materials are produced from starch by hydrolysis.
- Starch is a polymer of anhydro-D-glucose units. Hydrolysis of starch produces a mixture of polymers of various molecular weights ranging from 200 glucose units or more down to maltose (2 glucose units) and D- glucose itself. Because of their nature the accepted way to describe the polymers formed by hydrolysis of starch is by their DE. value, which is an expression of the average extent of hydrolysis.
- the hydrolysatematerial may be subjected to further purification steps known to the art such as carbon or clay treatment, dialysis, electrodialysis, osmosis, ion exclusion, ion exchange and the like.
- the starch hydrolysate material employed in practicing the invention may be prepared from starch by a number of specific methods.
- a starch such as waxy starch
- a single enzyme application of bacterial alpha-amylase More specifically, an aqueous slurry of a starch such as waxy starch having a solids content less than 50 percent is subjected to the hydrolytic action of bacterial alpha-amylase under suitable conditions to produce the starch hydrolysate material.
- This material is futher specifically characterized as having the sum of the percentages (dry basis) of saccharides therein with a degree of polymerization of 1 to 6, divided by the DE. to provide a ratio greater than about 2.0. This ratio is referred to as the characteristic or descriptive ratio.
- Those materials having a descriptive ratio less than about 2 are somewhat undesirable in that they exhibit less water solubility and also tend to form a haze in solution as compared to those products with a ratio of about 2 or greater.
- Suitable starch hydrolysate materials may also be made via a number of other routes.
- a mixture of starch and water having a solids content less than percent may be first subjected to the hydrolytic action of a bacterial alpha-amylase. After an initial thinning by the enzyme, the resulting partial hydrolysate is heated to a temperature sufficient to solubilize any unsolubilized starch. Since this temperature also tends to inactivate the enzyme, it is then necessary to subject the solubilized partial hydrolysate to a second hydrolysis by treatment with more bacterial alphaamylase to obtain the final starch hydrolysate.
- a third method of making the preferred class of starch hydrolysate materials consists of hydrolyzing a mixture of starch and water by the action of acid to reach a DB. of less than about 35.
- the partial hydrolysate is subsequently subjected to the action of bacterial alpha-amylase to obtain a starch hydrolysate having a DB. between 5 and 25.
- a particularly preferred product useful here has the following specifications: moisture content 5 percent maximum; 9] 3 DE; pH of4.5 to 5.5 when in aqueous solution at 10 percent solids; an average bulk density of 28-35 pounds per cubic foot and a descriptive ratio of about 2.
- starch or starch like material may be used to prepare the starch hydrolysate material used in the invention.
- Suitable materials include cereal and tuber starches, such as corn, wheat, potato, tapioca, rice, sago and grain sorghum, waxy starches may also be used.
- Hydrolysis may be carried out by enzymes, acids or combinations of the two.
- the materials used in practicing the invention should, of course, be sterile. Sterilization may be accomplished by any of the known sterilization procedures.
- EXAMPLE 1 The subject for this example was a 78 year old man afflicted with Buergers disease, or arteritis obliterans, that was manifested by chronic, foul smelling, seeping deep ulcerations of both legs. The subject was undernourished and previous attempts to treat the ulcers, by several standard methods, had failed. The ulcers were of a third degree depth, and extended along most of the length of the anterior aspect of the legs.
- the lesions on the right leg were selected for treatment with a sterile, purified starch hydrolysate particulate material.
- the lesions on the left leg were treated, as a control, with a nitrofurazone impregnated gauze, a widely used treatment for burns and ulcerated lesions. Bacteriological cultures were taken at various intervals from the lesions of both legs. The treated lesions were inspected every other day.
- the starch hydrolysate material in powdered particulate form was dusted, in a thin film, onto the ulcer bed or granulation tissue of the lesions upon the subjects right leg, it was wetted by the serum exudate present at the ulcer site, and shortly this wetted hydrolysateproduct dried up and formed a pliable, thin film. Over this newly formed film, a plain gauze dressing was placed. As compared to the lesions treated with the nitrofurazone impregnated gauze, there was a definite decrease in the amount of fluid exuded from the lesions treated with the starch hydrolysate product. In addition, there was a decrease in the odor of the test site, and a decrease in the pain. The color of the exudate formed at the starch hydrolysate treated site was of a light brown, caramel nature, as compared with the control site, which was a dark, ugly greenish-blue.
- the areas were inspected every other day. It was found that the epithelium began togrow in the ulcer that was treated with the starch hydrolysate product, both from the perimeter of the lesion and from the depth of the lesion. After 7 weeks, the test lesion had completely healed, or filled with newly formed epithelium. This new skin was flexible, warm and pink.
- EXAMPLE 2 The subject was a 13 year old girl with a third degree burn of the dorsal aspect of the right foot. The burn was thermal in nature, being caused by boiling water. The subject was treated with antibiotics. At the end of 14 days of treatment, separation of the eschar took place, leaving a deep area of granulation tissue. This area was treated, in the conventional manner, with nitrofurazone impregnated gauze. After a period of three weeks of treatment, the condition of the burn site remained unchanged and, in fact, became progressively more infected. At this point, as no growth of epithelium was observed, normally a split thickness skin auto-graft would have been applied in order to effect healing of the burn.
- Example 1 the following observations were made: there was decrease of pain from the moment of the application of the hydrolysate product; a decrease of the infection at the burn site; an improve ment in the quality and appearance of the granulation tissue; and a progressive growth of'the epithelium from the periphery towards the center of the burn site. After 5 weeks, the burn site was completely covered by newly formed epithelium, without any appreciable contracture. After 4 months, no contracture of scarswere observed in the area of the original burn site.
- EXAMPLE 3 The subject, a woman 51 years old, was affected with bilateral deep stasis ulcers of both legs, at the lower third of the leg. The right leg ulcer was rather small, and measured approximately 3 by 4 inches. The ulcer on the left leg, in contrast, covered completely around the leg in a circular fashion, and had a width of 5 inches.
- the drainage from both ulcers was considerable, the subject having to use several thicknesses of cotton dressing to control the drainage.
- the right leg ulcer was used as a control and treated,as in the examples above with nitrofurazone impregnated gauze.
- the left leg was dusted with'thestarch hydrolysate material of this invention, in powdered, particulate form every other day. After approximately 2 months, the leg treated with the starch hydrolysate product was almost completely cover'ed by newly formed skin, with the exception of a centrally located area, which continued to decrease in size as new epithelium formed.
- EXAMPLE 4 The subject for this example was a 56 year old woman who had had a deep stasis varicose ulcer on her right-leg (internal lower aspect) for approximately 20 years. The wound measured 6 inches by 4 inches'and of the thin film, as described above in Example 1, the
- purified starch hydrolysate material in powdered particulate form was applied in an amount sufficient to form a thin layer over the wound.
- the DB. of this material was about 9.9.
- the particulate material mixed with the exudate serum to form a film. If left uncovered, the film would dry up within an hour to form a solid, yet flexible covering over the ulcer site.
- This covering resembles a natural wound scab, and like a natural wound scab it prevents body fluids (i.e., plasma) from escaping and regulates temperature exchanges from the body through the wound.
- EXAMPLE 5 The subject was an 1 1 year old girl who had suffered first and second degree thermal burns (scalding water) on the left flank of her abdominal wall (her left side above the hip area). The burn site was 7 inches by 4 inches. To this burn area sterile, purified starch hydrolysate material in powdered, particulate form was applied in an amount sufficient to form a thin layer over the burn. The DB. of this material was about 9.9. On the second post-burn day the superficial layers came off having a second degree burn. After daily treatment with the particulate material for 6 days, the burn area was fully re-epithialized. There was no infection and no pain associated with the treatment.
- EXAMPLE 6 The subject was a 5 year old girl who had a second degree thennal burn (hot coffee) on her forearm. The burn was 3 inches by 1 inch and had three small areas 'of a third degree burn. The burn was treated as in Example 5 with sterile, purified starch hydrolysate material in powdered, particulate form on the third postburn day. At that time the burn was already infected. The DB of the material used was about 9.9. The material was applied every other day. After days the burn area was fully healed and covered by new epithelium including the third burn areas. One month later there was no evidence of scarring.
- EXAMPLE 7 In this test 40 young adult New Zealand strain albino rabbits, weighing between 2 and 3 kilograms, were first subjected to a third-degree burn over approximately 10 percent of their total body surface area and then separated into four test groups. Each test group consisted of five males and five females. One group was a control group and the burn site areas of the rabbits in the other three groups were treated with different dosages of a sterilized dispersion of a starch hydrolysate having a DB. of about 10 and a descriptive ratio of about 2.
- each rabbit was burned by immersion of the shaved surface in hot water, using a temperature of 90 C and exposure time of 4 seconds which was determined experimentally appropriate for producing a third-degree burn involving approximately 10 percent of the total body surface area.
- each rabbit was fitted with a lightweight, flexible, plastic collar which was worn throughout the investigation.
- test suspension was allowed to contact the skin for a period of 18 hours per day after which the skin was rinsed with warm sterile water and patted dry.
- the animals in each of the four groups were weighed weekly and several tests, including blood tests and urine analysis, were performed at the beginning of-the study and at the end of the 21 day test period.
Abstract
Description
Claims (4)
- 2. The method of claim 1 wherein the starch hydrolysate has a Dextrose Equivalent between about 5 and about 25.
- 3. The method of claim 1 wherein the starch hydrolysate has a Dextrose Equivalent between about 9 and about 13.
- 4. A method of treating skin wounds which comprises applying thereto an amount of a starch hydrolysate having a Dextrose Equivalent of less than about 35 effective to form a film over said wound.
- 5. The method of claim 4 wherein the starch hydrolysate has a descriptive ratio of about 2 or greater, the descriptive ratio being the quotient obtained by dividing the sum of the percentages of saccharide, dry basis, having a degree of polymerization of 1 to 6 by the dextrose equivalent.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00286741A US3812252A (en) | 1970-12-30 | 1972-09-08 | Method of treating wounds with a medicinal dressing |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10294270A | 1970-12-30 | 1970-12-30 | |
US00286741A US3812252A (en) | 1970-12-30 | 1972-09-08 | Method of treating wounds with a medicinal dressing |
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US3812252A true US3812252A (en) | 1974-05-21 |
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US00286741A Expired - Lifetime US3812252A (en) | 1970-12-30 | 1972-09-08 | Method of treating wounds with a medicinal dressing |
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Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0034504A2 (en) * | 1980-02-19 | 1981-08-26 | Anthony N. Silvetti, Sr. | Combinations for the treatment of wounds |
US4342745A (en) * | 1979-05-31 | 1982-08-03 | Zyma S.A. | Use of polyvinyl alcohols for the treatment of lesions |
US4361552A (en) * | 1980-09-26 | 1982-11-30 | Board Of Regents, The University Of Texas System | Wound dressing |
US4414202A (en) * | 1980-02-19 | 1983-11-08 | Silvetti Anthony N | Composition for treatment of wounds |
US4537767A (en) * | 1973-01-29 | 1985-08-27 | Pharmacia Aktiebolag | Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method |
US4556056A (en) * | 1977-06-03 | 1985-12-03 | Max-Planck-Gesellschaft Zur Forderung Der/Wissenschaften E.V. | Transparent fluid bandage material and the preparation and use thereof |
US4778679A (en) * | 1981-09-14 | 1988-10-18 | Silvetti Anthony N | Method and composition for treatment of wounds |
US4889844A (en) * | 1985-10-22 | 1989-12-26 | Silvetti Sr Anthony N | Fructose containing wound healing preparation |
US5284833A (en) * | 1991-06-24 | 1994-02-08 | Carrington Laboratories, Inc. | Wound cleanser |
EP0743323A1 (en) * | 1995-05-18 | 1996-11-20 | FARMACEUTICI DAMOR S.p.A. | Saccharide fraction obtainable from starch, its use as active principle in the treatment of wounds and ulcers and pharmaceutical compositions containing it |
US5858993A (en) * | 1994-03-28 | 1999-01-12 | Skin Biology, Inc. | Starch-metal complexes for skin and hair |
US6046178A (en) * | 1997-04-18 | 2000-04-04 | Deroyal Industries, Inc. | Method and compound for treating wounds with starch hydrolysate medication |
US20030220632A1 (en) * | 2002-05-23 | 2003-11-27 | Wolfgang Strasser | Method of using gel sheets for laser treatment |
US20040001878A1 (en) * | 2002-06-26 | 2004-01-01 | Deroyal Industries, Inc. | Infused wound care dressings |
WO2011068455A1 (en) | 2009-12-04 | 2011-06-09 | Magle Ab | Microspheres of hydrolysed starch with endogenous, charged ligands |
ITFI20120104A1 (en) * | 2012-06-04 | 2013-12-05 | Damor Farmaceutici | SACCHARID FRACTION FROM WHEAT, PROCESS FOR ISOLATION AND USE. |
WO2015050425A1 (en) | 2013-10-02 | 2015-04-09 | Pebisut De Mexico S.A. De C.V. | Anti-inflammatory composition for aiding and promoting the healing of chronic ulcerative lesions |
US9180219B2 (en) | 2008-06-06 | 2015-11-10 | Manukamed Limited | Compositions comprising honey and a super-absorbent material |
-
1972
- 1972-09-08 US US00286741A patent/US3812252A/en not_active Expired - Lifetime
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4537767A (en) * | 1973-01-29 | 1985-08-27 | Pharmacia Aktiebolag | Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method |
US4556056A (en) * | 1977-06-03 | 1985-12-03 | Max-Planck-Gesellschaft Zur Forderung Der/Wissenschaften E.V. | Transparent fluid bandage material and the preparation and use thereof |
US4342745A (en) * | 1979-05-31 | 1982-08-03 | Zyma S.A. | Use of polyvinyl alcohols for the treatment of lesions |
EP0034504A2 (en) * | 1980-02-19 | 1981-08-26 | Anthony N. Silvetti, Sr. | Combinations for the treatment of wounds |
EP0034504A3 (en) * | 1980-02-19 | 1982-10-13 | Anthony N. Silvetti | Combinations of components and individual substances, compositions and solutions for the treatment of wounds, and packs containing the combinations |
US4414202A (en) * | 1980-02-19 | 1983-11-08 | Silvetti Anthony N | Composition for treatment of wounds |
EP0172326A1 (en) * | 1980-02-19 | 1986-02-26 | Anthony N. Silvetti, Sr. | Compositions for the treatment of wounds |
US4361552A (en) * | 1980-09-26 | 1982-11-30 | Board Of Regents, The University Of Texas System | Wound dressing |
US4778679A (en) * | 1981-09-14 | 1988-10-18 | Silvetti Anthony N | Method and composition for treatment of wounds |
US4889844A (en) * | 1985-10-22 | 1989-12-26 | Silvetti Sr Anthony N | Fructose containing wound healing preparation |
US5284833A (en) * | 1991-06-24 | 1994-02-08 | Carrington Laboratories, Inc. | Wound cleanser |
US5858993A (en) * | 1994-03-28 | 1999-01-12 | Skin Biology, Inc. | Starch-metal complexes for skin and hair |
EP0743323A1 (en) * | 1995-05-18 | 1996-11-20 | FARMACEUTICI DAMOR S.p.A. | Saccharide fraction obtainable from starch, its use as active principle in the treatment of wounds and ulcers and pharmaceutical compositions containing it |
US6046178A (en) * | 1997-04-18 | 2000-04-04 | Deroyal Industries, Inc. | Method and compound for treating wounds with starch hydrolysate medication |
US20030220632A1 (en) * | 2002-05-23 | 2003-11-27 | Wolfgang Strasser | Method of using gel sheets for laser treatment |
US20090062781A1 (en) * | 2002-05-23 | 2009-03-05 | Ed. Geistlich Soehne Ag Fur Chemische Industrie | Method of using gel sheets for laser treatment |
US20040001878A1 (en) * | 2002-06-26 | 2004-01-01 | Deroyal Industries, Inc. | Infused wound care dressings |
US9180219B2 (en) | 2008-06-06 | 2015-11-10 | Manukamed Limited | Compositions comprising honey and a super-absorbent material |
WO2011068455A1 (en) | 2009-12-04 | 2011-06-09 | Magle Ab | Microspheres of hydrolysed starch with endogenous, charged ligands |
US9708416B2 (en) | 2009-12-04 | 2017-07-18 | Magle Ab | Microspheres of hydrolysed starch with endogenous, charged ligands |
ITFI20120104A1 (en) * | 2012-06-04 | 2013-12-05 | Damor Farmaceutici | SACCHARID FRACTION FROM WHEAT, PROCESS FOR ISOLATION AND USE. |
KR20150021043A (en) * | 2012-06-04 | 2015-02-27 | 파르마세우티시 다모르 에스.피.에이. | Saccharide fraction from wheat, isolation process and field of use of the invention |
WO2013182551A1 (en) * | 2012-06-04 | 2013-12-12 | Farmaceutici Damor S.P.A. | Saccharide fraction from wheat, isolation process and field of use of the invention |
US9895392B2 (en) | 2012-06-04 | 2018-02-20 | Farmaceutici Damor S.P.A. | Saccharide fraction from wheat, isolation process and field of use of the invention |
EA032318B1 (en) * | 2012-06-04 | 2019-05-31 | Фармачеутичи Дамор С.П.А. | Saccharide fraction from wheat, process for preparing same and use thereof |
WO2015050425A1 (en) | 2013-10-02 | 2015-04-09 | Pebisut De Mexico S.A. De C.V. | Anti-inflammatory composition for aiding and promoting the healing of chronic ulcerative lesions |
US9808484B2 (en) | 2013-10-02 | 2017-11-07 | Pebisut De Mexico S.A. De C.V. | Anti-inflammatory composition for aiding and promoting the healing of chronic ulcerative lesions |
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PTEF | Application for a patent term extension |
Free format text: PRODUCT NAME: GLUCOSIL; REQUESTED FOR 2 YEARS Filing date: 19890421 Expiry date: 19910521 Free format text: PRODUCT NAME: SIMON NITINOL FILTER; REQUESTED FOR 2 YEARS Filing date: 19890421 Expiry date: 19910521 |
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PTER | Rejection of a request for patent term extension (for eg. ineligible, dismissal, withdrawal, etc) |
Free format text: PRODUCT NAME: SIMON NITINOL FILTER Filing date: 19890421 Expiry date: 19910521 |
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Owner name: LANGE MEDICAL PRODUCTS, INC., ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:A.N.S. RESEARCH & DEVELOPMENT PARTNERS, L.P;SILVETTI, ANTHONY N.;SILVETTI, ANTHONY N., JR.;REEL/FRAME:010547/0860 Effective date: 19970523 Owner name: LANGE VENTURE PARTNERS, L.P., ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:A.N.S. RESEARCH & DEVELOPMENT PARTNERS, L.P;SILVETTI, ANTHONY N.;SILVETTI, ANTHONY N., JR.;REEL/FRAME:010547/0860 Effective date: 19970523 Owner name: LANGE ASSOCIATES LIMITED PARTNERSHIP, ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:A.N.S. RESEARCH & DEVELOPMENT PARTNERS, L.P;SILVETTI, ANTHONY N.;SILVETTI, ANTHONY N., JR.;REEL/FRAME:010547/0860 Effective date: 19970523 Owner name: WOUNDCARE ACQUISITION LLC, TENNESSEE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LANGE MEDICAL PRODUCTS, INC.;LANGE VENTURE PARTNERS, L.P.;LANGE ASSOCIATES LIMITED PARTNERSHIP;REEL/FRAME:010547/0867 Effective date: 19970523 |