|Número de publicación||US3823717 A|
|Tipo de publicación||Concesión|
|Fecha de publicación||16 Jul 1974|
|Fecha de presentación||16 Abr 1973|
|Fecha de prioridad||22 Abr 1972|
|También publicado como||DE2219790A1, DE2219790B2, DE2219790C3|
|Número de publicación||US 3823717 A, US 3823717A, US-A-3823717, US3823717 A, US3823717A|
|Inventores||Cichos M, Pohlman R|
|Cesionario original||Pohlman R|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (3), Citada por (140), Clasificaciones (13)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
United States Patent [191 Pohlman et a1.
APPARATUS'FOR DISINTEGRATING CONCRETIONS IN BODY CAVITIES OF LIVING ORGANISMS BY MEANS OF AN ULTRASONIC PROBE Reimar Pohlman; Manfred Cichos, both of Aachen, Germany Assignee: Reimar Pohlman, Aachen, Germany Filed: Apr. 16, 1973 Appl. No.: 351,140
Foreign Application Priority Data Apr. 22, 1972 Germany 2219790 U.S. Cl 128/305, 128/276, 128/328, 128/24 A Int. Cl A6lb 17/32 Field of Search 128/303, 24 A, 305, 276, 128/328, 319
Primary Examiner-Lawrence W. Trapp I [5 7 1 ABSTRACT An ultrasonic probe for disintegrating concretions e.g. urinary calculus, in body cavities comprises a probe tube, ultrasonically vibrated in a longitudinal direction, having at one end a tubular impact element loosely coupled to it in the direction of vibration. The impact element is provided on its free end with a cutting edge, preferably formed by a plurality of teeth. The disintegrated concretions are continuously evacuated through the tubular impact element and the tubular probe.
12 Claims, 7 Drawing Figures PATENTED JUL 1 s 1924 APPARATUS FOR DISINTEGRATING CONCRETIONS IN BODY CAVITIES OF LIVING ORGANISMS BY MEANS OF AN ULTRASONIC PROBE BACKGROUND OF THE INVENTION This invention relates to an apparatus for disintegrating concretions in body cavities of living organisms by means of an ultrasonic probe.
It is known to treat hard and brittle materials by means of ultrasonic vibrations. in this case a tool profiled in any desired manner and excited to longitudinal vibrations is lowered into the material to be treated with interposition of a boron carbide suspension. By this means perforations, dies etc. can be made in hard and brittle materials.
The present invention pursues a totally different purpose, namely to produce brittle fractures in hard and brittle bodies in order to destroy the said bodies, e.g. urinary calculus. By this means it is desired to destroy or disintegrate a urinary calculus presentin the human bladder to such an extent that the debris can be exhausted or removed from the bladder through natural channels without difficulty.
Now when it is attempted to obtain brittle fractures by means of ultrasonic vibrations, although e.g. in the case of disintegration of urinary calculus, relatively soft types of calculus such as phosphate calculus, can be reduced fairly rapidly by ultrasonic vibrations; on the other hand harder types, such as urate Calculus, oxalate calculus, can only be disintegrated into small debris extraordinarily slowly, or even not at all.
Known apparatusses operate on the principle that a concretion present in a body cavity is touched by a rodshaped ultrasonic probe introduced through natural channels, whereupon by pressing the concretion against the wall of the body cavity the ultrasonic vibrations are transmitted to the concretion and the latter is thereby destroyed. Because the pressure forces required in this case are relatively powerful. there is a risk, more particularly with small smooth concretions, that the sonic probe may slip off, so that the wall of the body cavity may become damaged. Moreover, if such small smooth concretions are also extremely hard, then in the majority of cases they cannot be disintegrated at all by this procedure, because they move away at the very first contact by the ultrasonic probe.
Furthermore, the known apparatus suffers from an other disadvantage. When it is actually possible to disintegrate a concretion, then in every case initially the disintegrated debris of the calculus and the stone dust suspended in the liquor are left behind in the body cavity. This gives rise to on the one hand to a visual obstruction for the optical examination instrument (endoscope) introduced with the ultrasonic probe, and on the other hand to the necessity of removing the stone residues from the body cavity by a separate operation, which furthermore can no longer be performed under visual control. For this purpose the ultrasonic probe must be removed out of the body cavity and another instrument, for example a so-called suction syringe, must be used.
SUMMARY OF THE lNVENTlON The invention aims at providing an apparatus for disintegrating concretions in body cavities by means of an ultrasonic probe, whereby the disadvantages of the apparatusses of this type hitherto known are obviated.
To this end, the present invention consists in an apparatus for disintegrating concretions in body cavities in living organisms, comprising a tubular probe ultrasonically vibrated longitudinally and a tubular impact element loosely coupled in the direction of vibration to one end of said tubular probe whereby the ultrasonic vibrations transmitted to the impact element are transformed into shock forces.
Due to the interposition of the impact element, the shattering effect of the ultrasonic vibrations is increased by orders of magnitude. The impact element should be as hard and highly elastic as possible, and is arranged loosely between the ultrasonic probe and the body to be disintegrated. This unyielding element is capable of collecting impulse shocks statistically from the ultrasonic vibrations acting periodically upon it, and to transmit them in very brief and highly intensive impact shocks to the body to be disintegrated. lt has been found that these collected" highly intensive impulse shocks can achieve orders of magnitude and can initiate percussive forces which exceed many times the pressure peaks transmitted periodically by the ultrasonic probe tube and are capable of causing the desired brittle fractures. Even the hardest types or urinary calculus (urate and oxalate calculus) can be destroyed by this means.
By virtue of the tubular construction of the impact element and of the ultrasonic probe tube, it becomes possible to exhaust the fragments of calculus continuously by an exhauster device as they are detached during the actual disintegration operation, so that it is unnecessary to use additionally a further apparatus to exhaust them after the disintegration of the concretion. Furthermore, the continuous exhaustion of the fragments of calculus and of the stone dust produce the further advantage that no obstruction of vision for the optical observation instrument (endoscope) occurs. And
lastly, the exhaustion of the fragments of calculus also sucks the calculus itself towards the front end of the tubular impact element, so that on the one hand it centres itself automatically upon the impact element, so that the latter is largely prevented from slipping off, while at the same time a certain'contact pressure is generated whereby the contact force against the wall of the body cavity which was hitherto necessary is substantially reduced. Since furthermore the shocks of the impact element only have a destructive effect when they strike hard bodies, no injury to the soft wall of the body cavity occurs even if the latter is accidentally touched.
The characteristic property of the impact element to transform the ultrasonic vibrations transmitted to it into powerful shock forces of low frequency produces a number of advantages:
Only a much weaker contact pressure is required to achieve the desired effect, compared to the apparatusses hitherto known. Furthermore, it is possible to destroy with ultrasonic vibrations of hitherto customary amplitude and power, concretions which would have withstood destruction without the interposition of an impact element.
Preferably, the end of the tubular impact element remote from said coupling is constructed as a cutting edge which may advantageously be constituted by a plurality of teeth. The efficacity of the destruction of concretions is increased by these measures.
It is furthermore advantageous to make the teeth of undercut trapezoidal construction so that their cutting surfaces are larger than their root surfaces, since in this manner the disintegrated culculus material can easily be discharged by the exhaustion operation. Furthermore, if the teeth are arranged mutually joggled or twisted, so that their cutting edges project partly beyond the outer circumference of the tube supporting them and into the interior space of the said tube, then on the one hand the risk of the impact element seizing in the calculus is reduced, while on the other hand it has the effect that the diameter of the hole generated is greater than the diameter of the impact element carrying the teeth, and the stone fragments are smaller than the internal diameter of the impact element and of the tubular ultrasonic probe. In this way a clogging of the entire instrument by the disintegrated stones is reliably obviated. Furthermore the advantage is obtained that with this mode of construction the tubular impact element tends to dance" in the peripheral direction, so that it repeatedly strikes fresh points of the concretion to be destroyed.
The impact element is preferably guided loosely with slight radial and axial play on the end of the ultrasonic probe tube. In this case the impact element can be prevented from falling out by various measures which later be more fully explained.
It has further been found particularly advantageous to construct the ultrasonic vibrator tube and/or the impact element coupled to it, at the mutual contact surfaces, so that a linear or punctiform contact occurs, since in the case of an areal contact the recoil of the element is considerably impaired by the adherence layer of interlying liquid. The elastic shock conditions are also appreciably improved.
BRIEF DESCRIPTION OF THE DRAWINGS In order that the invention may be more readily understood. reference is made to the accompanying drawings which illustrate diagrammatically and by way of example several embodiments thereof, and in which:
FIG. 1 shows the front end of an ultrasonic probe with tubular impact element. partly in section;
FIG. 2 shows the side elevation of the cutting edge of the impact element with trapezoidal teeth;
FIG. 3 shows the plan of the cutting edge with twisted teeth and of the impact-element (in a section along the line III-III of FIG. 1);
FIG. 4 shows an impact element with rounded and corrugated impact surface;
FIG. 5 shows an impact element with conical impact surface and cap sleeve;
FIG. 6 shows an impact element with helicoidal spring retaining means; and
FIG. 7 shows an impact element with tubular retaining means.
DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring to FIG. 1, an ultrasonic probe comprises a tube 1 and an impact element 2. The tube 1 is oscillated longitudinally by an ultrasonic generator indicated by the double arrow 27. The impact element 2 is likewise of tubular construction and carries at one end teeth 7 as a cutting edge. Due to the longitudinal oscillations of the tube 1, impulses are transmitted to the impact element 2, which are intensified in the above described manner into very powerful impulse peaks, because the "impact element 2 is supported loosely in the radial and axial direction in or on the tube 1. The loose mounting ofthe impact element is ensured in that a sufficient tolerance in the radial direction is provided by shank guide means 4 in the end of the tube 1, whilst axial movement of the impact element 2 is limited on the one hand by an impact surface 3 on the element 2 and on the other hand by retaining pins 5, 5 which engage in slots 6, 6' in the impact element 2, so that the impact element 2 is prevented from dropping out of the tube 1. The teeth 7 of the impact element 2 constructed as a tube section are arranged joggled, so that only those fragments of the concretion treated which have a smaller diameter than that of the tube can penetrate into the tube 1, so that easy evacuation of the fragments in the direction of the arrow 27 through the tube 1 is possible.
As FIG. 2 shows, the teeth 7 are advantageously of trapezoidal construction with their wide side acting as chisels, so that they do not jam in the case ofa less brittle concretions, but can automatically bore themselves free. The discharge of the material to the exhaustor device is furthermore greatly facilitated by this means.
FIG. 3 illustrates the impact element 2 viewed axially in plan and partly in section along the line Ill-Ill of FIG. 1. The teeth 7 are arranged twisted so that a line connecting the outer edges of the teeth has a greater diameter than the outside diameter D of the impact element 2, whilst a line connecting the inner edges of the teeth has a smaller diameter than the inside diameter d of the impact element 2.
FIG. 4 shows a construction of the impact surfaces at the front end of the ultrasonic probe tube 8 and on the impact element 9. The end of the tube 8 is substantially conically countersunk at its end face 9a, whereby an automatic centering of the impact element 9 is created. The impact element 9 is rounded at its contact surface 10, so that its rests not upon a plane surface but only upon an encircling line. If desired, the rounded support surfaces 10 may be corrugated as at 100, so that only support points remain.
FIG. 5 shows the mode of supporting an impact element 1] on an ultrasonic probe tube 12 by a cap sleeve 13. In this case, for the purpose of automatic centering, both the impact surfaces l4, 15 are conically tapered.
FIG. 6 illustrates an embodiment in which an impact element 16 is loosely supported on an ultrasonic probe tube 17 by means of a helical spring 18. The spring is dimensioned so that in the rest position a small gap 19 remains between the impact element I6 and the tube 17, which is closed only when the impact element 16 is pressed against the tube 17, so that energy is transmitted only then. By virtue of this construction, during idle running, the excited but inoperative ultrasonic vibrator does not touch the impact element at all and avoids unnecessary wear of the impact surfaces and stressing of the support means.
FIG. 7 shows means for supporting an impact element 20 on an ultrasonic probe tube 21 by means of a soft resilient sleeve 22 which can be adjusted so that again a small gap 23 remains between impact surfaces 24, 25. The impact surfaces may be rounded and/or conically tapered.
1. An apparatus for disintegrating concretions in body cavities in living organisms, comprising a tubular probe adapted to be ultrasonically vibrated longitudinally and a tubular impact element loosely coupled in the direction of vibration to one end of said tubular probe whereby the ultrasonic vibrations transmitted to the impact element are transformed into shock forces.
2. An apparatus as claimed in claim I, wherein the end of the tubular impact element remote from said coupling is constructed as a cutting edge.
3. An apparatus as claimed in claim 2, wherein the cutting edge is constituted by a plurality of teeth.
4. An apparatus as claimed in claim 3, wherein the teeth are of an undercut. trapezoidal construction so that their cutting surfaces are larger than their root surfaces.
5. An apparatus as claimed in claim 3, wherein the teeth are arranged mutually joggled or twisted so that a line connecting the outer edges of the teeth has a greater diameter than the external diameter of the impact element and a line connecting the inner edges of the teeth has a smaller diameter than the internal diameter of the impact element.
6. An apparatus as claimed in any of the claim 2, wherein the impact element is guided loosely with slight radial and axial play on the end of the tubular probe.
7. An apparatus as claimed in claim 6, wherein the impact element is prevented from dropping out of the tubular probe by retaining pins which engage in slots provided in the impact element.
8. An apparatus as claimed in claim 6, wherein the impact element is loosely supported by a cap sleeve secured to the tubular probe.
9. An apparatus as claimed in claim 6, wherein the impact element is supported by a helicoidal spring contacting the tubular probe and the impact element.
10. An apparatus as claimed in claim 6, wherein the impact element is supported by a resilient tube contacting the tubular probe and the impact element.
11. An apparatus as claimed in claim 6, wherein those parts of the ultrasonic probe tube and of the impact element where the two components are in mutual contact during their axial movement caused by the ultrasonic vibrations are of tapered construction of at least one of said parts.
12. An apparatus as claimed in claim 1, wherein the ultrasonic probe tube is adapted to be connected to an exhaustor device.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US3352303 *||28 Jul 1965||14 Nov 1967||Lawrence J Delaney||Method for blood clot lysis|
|US3433226 *||21 Jul 1965||18 Mar 1969||Aeroprojects Inc||Vibratory catheterization apparatus and method of using|
|US3526219 *||21 Jul 1967||1 Sep 1970||Ultrasonic Systems||Method and apparatus for ultrasonically removing tissue from a biological organism|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US4748971 *||30 Ene 1987||7 Jun 1988||German Borodulin||Vibrational apparatus for accelerating passage of stones from ureter|
|US4750488 *||27 Feb 1987||14 Jun 1988||Sonomed Technology, Inc.||Vibration apparatus preferably for endoscopic ultrasonic aspirator|
|US4750902 *||19 May 1986||14 Jun 1988||Sonomed Technology, Inc.||Endoscopic ultrasonic aspirators|
|US4823793 *||30 Oct 1985||25 Abr 1989||The United States Of America As Represented By The Administrator Of The National Aeronuautics & Space Administration||Cutting head for ultrasonic lithotripsy|
|US4838853 *||5 Feb 1987||13 Jun 1989||Interventional Technologies Inc.||Apparatus for trimming meniscus|
|US4907572 *||18 Abr 1989||13 Mar 1990||Urological Instruments Research, Inc.||Vibrational method for accelerating passage of stones from ureter|
|US4911149 *||7 Sep 1988||27 Mar 1990||Urological Instruments Research, Inc.||Vibratory treatment method and apparatus|
|US4922902 *||16 Dic 1987||8 May 1990||Valleylab, Inc.||Method for removing cellular material with endoscopic ultrasonic aspirator|
|US5019083 *||31 Ene 1989||28 May 1991||Advanced Osseous Technologies, Inc.||Implanting and removal of orthopedic prostheses|
|US5058570 *||27 Nov 1986||22 Oct 1991||Sumitomo Bakelite Company Limited||Ultrasonic surgical apparatus|
|US5103556 *||14 Sep 1990||14 Abr 1992||Circon Corporation||Method of manufacturing an electrohydraulic probe|
|US5116343 *||28 Ago 1990||26 May 1992||Richard Wolf Gmbh||Device for disintegrating concretions disposed in body cavities|
|US5154722 *||14 Sep 1990||13 Oct 1992||Circon Corporation||Electrohydraulic probe having a controlled discharge path|
|US5243997 *||14 Sep 1992||14 Sep 1993||Interventional Technologies, Inc.||Vibrating device for a guide wire|
|US5246447 *||5 Mar 1992||21 Sep 1993||Physical Sciences, Inc.||Impact lithotripsy|
|US5267954 *||5 May 1992||7 Dic 1993||Baxter International Inc.||Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels|
|US5269291 *||10 Dic 1990||14 Dic 1993||Coraje, Inc.||Miniature ultrasonic transducer for plaque ablation|
|US5284484 *||29 May 1991||8 Feb 1994||Advanced Osseous Technologies, Inc.||Apparatus for implantation and extraction of osteal prostheses|
|US5295955 *||14 Feb 1992||22 Mar 1994||Amt, Inc.||Method and apparatus for microwave aided liposuction|
|US5304115 *||11 Ene 1991||19 Abr 1994||Baxter International Inc.||Ultrasonic angioplasty device incorporating improved transmission member and ablation probe|
|US5312328 *||9 Jul 1992||17 May 1994||Baxter International Inc.||Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels|
|US5318570 *||11 Jun 1991||7 Jun 1994||Advanced Osseous Technologies, Inc.||Ultrasonic tool|
|US5324255 *||10 Jul 1992||28 Jun 1994||Baxter International Inc.||Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm|
|US5324297 *||5 Mar 1991||28 Jun 1994||Advanced Osseous Technologies, Inc.||Ultrasonic tool connector|
|US5326342 *||8 Jul 1992||5 Jul 1994||Baxter International Inc.||Ultrasonic angioplasty device incorporating all ultrasound transmission member made at least partially from a superlastic metal alloy|
|US5334183 *||9 Abr 1992||2 Ago 1994||Valleylab, Inc.||Endoscopic electrosurgical apparatus|
|US5342292 *||24 May 1993||30 Ago 1994||Baxter International Inc.||Ultrasonic ablation device adapted for guidewire passage|
|US5344395 *||24 Ene 1992||6 Sep 1994||Scimed Life Systems, Inc.||Apparatus for intravascular cavitation or delivery of low frequency mechanical energy|
|US5368557 *||5 May 1993||29 Nov 1994||Baxter International Inc.||Ultrasonic ablation catheter device having multiple ultrasound transmission members|
|US5368558 *||3 Jun 1993||29 Nov 1994||Baxter International Inc.||Ultrasonic ablation catheter device having endoscopic component and method of using same|
|US5380273 *||19 May 1993||10 Ene 1995||Dubrul; Will R.||Vibrating catheter|
|US5380274 *||12 Oct 1993||10 Ene 1995||Baxter International Inc.||Ultrasound transmission member having improved longitudinal transmission properties|
|US5382228 *||28 Sep 1993||17 Ene 1995||Baxter International Inc.||Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device|
|US5382251 *||14 Feb 1992||17 Ene 1995||Biomet, Inc.||Plug pulling method|
|US5390678 *||12 Oct 1993||21 Feb 1995||Baxter International Inc.||Method and device for measuring ultrasonic activity in an ultrasound delivery system|
|US5397301 *||19 Jul 1993||14 Mar 1995||Baxter International Inc.||Ultrasonic angioplasty device incorporating an ultrasound transmission member made at least partially from a superelastic metal alloy|
|US5405318 *||28 Sep 1993||11 Abr 1995||Baxter International Inc.||Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels|
|US5417672 *||4 Oct 1993||23 May 1995||Baxter International Inc.||Connector for coupling an ultrasound transducer to an ultrasound catheter|
|US5425735 *||22 Sep 1993||20 Jun 1995||Psi Medical Products, Inc.||Shielded tip catheter for lithotripsy|
|US5427118 *||4 Oct 1993||27 Jun 1995||Baxter International Inc.||Ultrasonic guidewire|
|US5443078 *||29 Jun 1994||22 Ago 1995||Interventional Technologies, Inc.||Method for advancing a guide wire|
|US5447509 *||4 Oct 1993||5 Sep 1995||Baxter International Inc.||Ultrasound catheter system having modulated output with feedback control|
|US5456686 *||25 Oct 1993||10 Oct 1995||Biomet, Inc.||Implantation and removal of orthopedic prostheses|
|US5474530 *||8 Jun 1994||12 Dic 1995||Baxter International Inc.||Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasospasm|
|US5492528 *||5 Dic 1994||20 Feb 1996||Anis; Azis Y.||Removal of tissue|
|US5524635 *||24 Oct 1994||11 Jun 1996||Interventional Technologies Inc.||Apparatus for advancing a guide wire|
|US5562609 *||7 Oct 1994||8 Oct 1996||Fibrasonics, Inc.||Ultrasonic surgical probe|
|US5562610 *||7 Oct 1994||8 Oct 1996||Fibrasonics Inc.||Needle for ultrasonic surgical probe|
|US5626560 *||13 Nov 1995||6 May 1997||Soring Medizintechnik Gmbh||Diathermic hand-held instrument with an endoscopic probe|
|US5722945 *||1 Abr 1996||3 Mar 1998||Aziz Yehia Anis||Removal of tissue|
|US5725570 *||29 Feb 1996||10 Mar 1998||Boston Scientific Corporation||Tubular medical endoprostheses|
|US5730718 *||29 Abr 1996||24 Mar 1998||Aziz Yehia Anis||Removal of tissue|
|US5827292 *||12 Feb 1996||27 Oct 1998||Anis; Aziz Yehia||Removal of tissue|
|US5906623 *||29 Jul 1997||25 May 1999||Boston Scientific Corporation||Lithotripsy system|
|US5957882 *||12 Mar 1997||28 Sep 1999||Advanced Cardiovascular Systems, Inc.||Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels|
|US6277084||5 May 1997||21 Ago 2001||Boston Scientific Corporation||Ultrasonic medical device|
|US6287271||9 Ene 1998||11 Sep 2001||Bacchus Vascular, Inc.||Motion catheter|
|US6287331||12 May 1998||11 Sep 2001||Boston Scientific Corporation||Tubular medical prosthesis|
|US6290721||21 Oct 1997||18 Sep 2001||Boston Scientific Corporation||Tubular medical endoprostheses|
|US6375651||18 Feb 2000||23 Abr 2002||Scimed Life Systems, Inc.||Laser lithotripsy device with suction|
|US6440123 *||9 Abr 1998||27 Ago 2002||Konrad Engel||Metal probe for use in intracorporeal lithotripsy|
|US6497709||5 May 1997||24 Dic 2002||Boston Scientific Corporation||Metal medical device|
|US6508782||16 Ago 2000||21 Ene 2003||Bacchus Vascular, Inc.||Thrombolysis device|
|US6517531||27 Abr 2001||11 Feb 2003||Scimed Life Systems, Inc.||Medical suction device|
|US6527802||23 Sep 1997||4 Mar 2003||Scimed Life Systems, Inc.||Clad composite stent|
|US6689086||29 Jul 1999||10 Feb 2004||Advanced Cardiovascular Systems, Inc.||Method of using a catheter for delivery of ultrasonic energy and medicament|
|US6726681||15 Mar 2002||27 Abr 2004||Scimed Life Systems, Inc.||Laser lithotripsy device with suction|
|US6752801 *||27 Jun 2002||22 Jun 2004||Konrad Engel||Metal probe for intracorporeal calculi crushing|
|US6929632||27 Jun 2002||16 Ago 2005||Advanced Cardiovascular Systems, Inc.||Ultrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels|
|US6936025||1 Nov 2000||30 Ago 2005||Bacchus Vascular, Inc.||Thrombolysis device|
|US6942677||26 Feb 2003||13 Sep 2005||Flowcardia, Inc.||Ultrasound catheter apparatus|
|US7101392||8 Ago 2001||5 Sep 2006||Boston Scientific Corporation||Tubular medical endoprostheses|
|US7104983||16 Mar 2004||12 Sep 2006||Boston Scientific Scimed, Inc.||Laser lithotripsy device with suction|
|US7137963||26 Ago 2002||21 Nov 2006||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US7220233||8 Abr 2003||22 May 2007||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US7335180||24 Nov 2003||26 Feb 2008||Flowcardia, Inc.||Steerable ultrasound catheter|
|US7393330||16 Feb 2006||1 Jul 2008||Broncus Technologies, Inc.||Electrosurgical device having hollow tissue cutting member and transducer assembly|
|US7422563||21 Feb 2002||9 Sep 2008||Broncus Technologies, Inc.||Multifunctional tip catheter for applying energy to tissue and detecting the presence of blood flow|
|US7462162||19 Jul 2004||9 Dic 2008||Broncus Technologies, Inc.||Antiproliferative devices for maintaining patency of surgically created channels in a body organ|
|US7540852||26 Ago 2004||2 Jun 2009||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US7540868||4 Nov 2002||2 Jun 2009||Boston Scientific Scimed, Inc.||Medical suction device|
|US7540870||27 Ago 2007||2 Jun 2009||Bacoustics, Llc||Ablative ultrasonic-cryogenic apparatus|
|US7604608||14 Ene 2003||20 Oct 2009||Flowcardia, Inc.||Ultrasound catheter and methods for making and using same|
|US7621902||24 Ago 2006||24 Nov 2009||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US7621929||11 Jul 2005||24 Nov 2009||Flowcardia, Inc.||Ultrasound catheter apparatus|
|US7708712||19 Jul 2004||4 May 2010||Broncus Technologies, Inc.||Methods and devices for maintaining patency of surgically created channels in a body organ|
|US7803168||9 Dic 2005||28 Sep 2010||The Foundry, Llc||Aortic valve repair|
|US7955293||23 Ago 2006||7 Jun 2011||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US8043251||7 Ago 2009||25 Oct 2011||Flowcardia, Inc.||Ultrasound catheter and methods for making and using same|
|US8062289||24 Abr 2009||22 Nov 2011||Bacoustics, Llc||Ablative ultrasonic-cryogenic apparatus|
|US8062566||25 Jul 2006||22 Nov 2011||Flowcardia, Inc.||Method of manufacturing an ultrasound transmission member for use in an ultrasound catheter device|
|US8100892||24 Abr 2009||24 Ene 2012||Boston Scientific Scimed, Inc.||Medical suction device|
|US8133236||7 Nov 2006||13 Mar 2012||Flowcardia, Inc.||Ultrasound catheter having protective feature against breakage|
|US8152753||7 Ago 2009||10 Abr 2012||Flowcardia, Inc.||Ultrasound catheter and methods for making and using same|
|US8221343||20 Ene 2005||17 Jul 2012||Flowcardia, Inc.||Vibrational catheter devices and methods for making same|
|US8226566||12 Jun 2009||24 Jul 2012||Flowcardia, Inc.||Device and method for vascular re-entry|
|US8246643||18 Jul 2008||21 Ago 2012||Flowcardia, Inc.||Ultrasound catheter having improved distal end|
|US8308677||3 Jun 2011||13 Nov 2012||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US8409167||5 Oct 2006||2 Abr 2013||Broncus Medical Inc||Devices for delivering substances through an extra-anatomic opening created in an airway|
|US8496669||21 Dic 2007||30 Jul 2013||Flowcardia, Inc.||Ultrasound catheter having protective feature against breakage|
|US8506519||16 Jul 2007||13 Ago 2013||Flowcardia, Inc.||Pre-shaped therapeutic catheter|
|US8608724||4 Nov 2010||17 Dic 2013||Broncus Medical Inc.||Devices for delivering substances through an extra-anatomic opening created in an airway|
|US8613751||28 Ene 2008||24 Dic 2013||Flowcardia, Inc.||Steerable ultrasound catheter|
|US8617096||1 Feb 2011||31 Dic 2013||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US8641630||7 Jul 2010||4 Feb 2014||Flowcardia, Inc.||Connector for securing ultrasound catheter to transducer|
|US8647293||22 May 2008||11 Feb 2014||Flowcardia, Inc.||Therapeutic ultrasound system|
|US8668709||25 Feb 2008||11 Mar 2014||Flowcardia, Inc.||Steerable ultrasound catheter|
|US8672928||16 Dic 2011||18 Mar 2014||Boston Scientific Scimed, Inc.||Medical suction device|
|US8679049||17 Jul 2012||25 Mar 2014||Flowcardia, Inc.||Device and method for vascular re-entry|
|US8690819||9 Nov 2012||8 Abr 2014||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US8709034||13 May 2011||29 Abr 2014||Broncus Medical Inc.||Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall|
|US8784400||16 May 2012||22 Jul 2014||Broncus Medical Inc.||Devices for delivering substances through an extra-anatomic opening created in an airway|
|US8790291||22 Abr 2009||29 Jul 2014||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US8932316||7 Abr 2014||13 Ene 2015||Broncus Medical Inc.||Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall|
|US8956375||23 Sep 2011||17 Feb 2015||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US8961423||1 Oct 2009||24 Feb 2015||Flowcardia, Inc.||Ultrasound catheter apparatus|
|US9034032||19 Jul 2013||19 May 2015||Twelve, Inc.||Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods|
|US9034033||19 Jul 2013||19 May 2015||Twelve, Inc.||Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods|
|US9039757||15 Mar 2013||26 May 2015||Twelve, Inc.||Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods|
|US20040138570 *||14 Ene 2003||15 Jul 2004||Flowcardia, Inc., A Delaware Corporation||Ultrasound catheter and methods for making and using same|
|US20040167507 *||26 Feb 2003||26 Ago 2004||Flowcardia, Inc.||Ultrasound catheter apparatus|
|US20040204670 *||8 Abr 2003||14 Oct 2004||Flowcardia, Inc., A Delaware Corporation||Ultrasound catheter devices and methods|
|US20040243123 *||16 Mar 2004||2 Dic 2004||Scimed Life Systems, Inc.||Laser lithotripsy device with suction|
|US20050043752 *||19 Jul 2004||24 Feb 2005||Broncus Technologies, Inc.||Methods and devices for maintaining patency of surgically created channels in a body organ|
|US20050113688 *||24 Nov 2003||26 May 2005||Flowcardia, Inc.,||Steerable ultrasound catheter|
|US20050245951 *||11 Jul 2005||3 Nov 2005||Flowcardia, Inc., A Delaware Corporation||Ultrasound catheter apparatus|
|US20140336666 *||9 May 2014||13 Nov 2014||Gyrus Acmi, Inc., D.B.A. Olympus Surgical Technologies America||Oscillating lithotripter|
|USRE37024||12 Sep 1997||16 Ene 2001||Boston Scientific Corporation||Endoscopic lithotripsy system|
|CN101401755B||25 Sep 2008||23 Ene 2013||株式会社尼德克||Head for ultrasonic operation and knife head for ultrasonic operation|
|EP0617590A1 *||16 Dic 1992||5 Oct 1994||Psi Medical Products, Inc.||Shielded tip catheter|
|EP0820727A2||4 May 1993||28 Ene 1998||Baxter International Inc.||Ultrasonic angioplasty catheter device|
|EP0820728A2||4 May 1993||28 Ene 1998||Baxter International Inc.||Ultrasonic angioplasty catheter device|
|EP2417945A2||19 Mar 2004||15 Feb 2012||Flowcardia Inc.||Improved ultrasound catheter devices and methods|
|EP2471474A1||13 Feb 2004||4 Jul 2012||Flowcardia Inc.||Ultrasound catheter apparatus|
|EP2609878A1||19 Mar 2004||3 Jul 2013||FlowCardia, Inc.||Improved ultrasound catheter devices and methods|
|WO1993011711A1 *||16 Dic 1992||24 Jun 1993||Psi Medical Products Inc||Shielded tip catheter|
|WO1996039955A1 *||11 Oct 1995||19 Dic 1996||Will R Dubrul||Vibrating catheter|
|WO2004018019A2||26 Ago 2003||4 Mar 2004||Flowcardia Inc||Ultrasound catheter for disrupting blood vessel obstructions|
|WO2004093736A2||19 Mar 2004||4 Nov 2004||Flowcardia Inc||Improved ultrasound catheter devices and methods|
|WO2005053769A2||25 Oct 2004||16 Jun 2005||Flowcardia Inc||Steerable ultrasound catheter|
|Clasificación de EE.UU.||606/128, 601/4, 604/22, 606/169|
|Clasificación internacional||A61B17/22, B02C19/18, B02C19/00, A61B17/32|
|Clasificación cooperativa||A61B17/22012, A61B2017/320072, B02C19/18|
|Clasificación europea||B02C19/18, A61B17/22B2|