US3838689A - Disposable syringe with slit valve - Google Patents

Disposable syringe with slit valve Download PDF

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US3838689A
US3838689A US00332643A US33264373A US3838689A US 3838689 A US3838689 A US 3838689A US 00332643 A US00332643 A US 00332643A US 33264373 A US33264373 A US 33264373A US 3838689 A US3838689 A US 3838689A
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tubular member
inner tubular
syringe
outer tubular
forward end
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M Cohen
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed

Definitions

  • This invention relates to a device for the administration of parenteral solutions and more particularly to a hypodermic syringe adapted to contain dry solids separate and apart from the dissolving or carrier liquids until, immediately prior to administration, the liquid is caused to flow into the compartment containing the solids for injection of the formed mixture.
  • the most effective means for maintaining the shelf life over extended periods of time is to maintaincomplete separation between the liquid carrier and the solids to be incorporated therein, until immediately prior to use. Maintenance of solid liquid separation until time of use presents other problems with respect to ejecting and administering the solution containing the necessary concentration of ingredients and under the most sanitary conditions.
  • the usual practice is to introduce the solids into the liquid for solution in a suitable container from which the solution can be withdrawn into a syringe for injection. This procedure required the use of at least three separate containers and maintenance under sterile conditions as well as accurate measurement of the ingredients.
  • FIG. 1 is a sectional elevational view of the syringe embodying the features of this invention, with the elements illustrated prior to use;
  • FIG. 2 is a sectional elevational .view of the syringe shown in FIG. I with the syringe partially'actuated to effect displacement of the liquid carrier from the liguid chamber to the solids chamber for solution or admixture;
  • FIG. 3 is a sectional elevational view of the syringe shown in FIGS. 1 and 2 with the syringe in fully actuated position to effect displacement of the freshly prepared solution from the solids compartment for injection;
  • FIG. 4 is a sectional elevational view of a portion of the syringe shown in FIGS. 1 to 3 and showing a modification in the closure for the liquid containing compartment;
  • FIG. 5 is a sectional elevational view of the actuator which may also be used as a needle cover.
  • the syringe of this invention is formed with an outer casing l in the form of a tubular member, formed of glass, plastic or the like, having a continuous bore 2 extending therethrough from an open rearward end portion 3 to a neck portion 4 of smaller cross-section, at the forward end.
  • the forward end is sealed by means of a disc member 5 held in place in sealing relationship across the open neck 6 of the tubular member I by means of a metal cap 7 which is crimped about the outer neck end portion of the tubular member while the inner portions 8 of the cap overlap the outer edge portions of the sealing disc member overlying the flattened end surface 9 of the tubular member.
  • the rearward end of the tubular member is formed with an outwardly extending annular flange 10 which serves as a finger grip.
  • a hub member 11 has a skirt portion 12 crimped about the skirt portion of the cap for securing the hub onto the neck end portion of the tubular member.
  • the hub is also formed with an intermediate collapsible or corrugated portion 13 extending forwardly in axial alignment with the forward end of the tubular member with a hub 14 on the forward end through which a hollow needle 15 extends with a sharpened end portion of the needle projecting into the interior of the hub member 11 for a distance less than the spaced relationship between the hub end and the diaphragm 5, when in normal position, thereby to locate the rearward end of the needle immediately in advance of the center of the diaphragm.
  • a second tubular member of glass, plastic or the like material is dimensioned to have an outer wall to wall dimension which is less than the inner wall to wall dimension of the tubular member 1 to enable the former to be telescoped through the interior of the outer tubular member 1.
  • the second tubular member is similarly formed with a passage 21 extending from the open rearward end 22 through a neck portion 23 of smaller cross-section at the forward end.
  • the forward neck end portion of the second tubular member is fitted with a rubber stopper 24 including an outer ribbed portion 25 fitted in gripping relationship about the neck and extending laterally beyond the walls of the second tubular member for a distance to effect sealing engagement with the inner walls of the outer tubular member 1 whereby the second tubular member is capable of the function of a piston movable axially relative the outer tubular member 1 thereby to provide a piston andcylinder arrangement between the two tubular members.
  • the rubber stopper 25 has a disc portion 26 which normally spans the forward end of the passage to seal the tubular member. It is further formed with one or more openings 27 in the lateral portions beyond the passage to enable flow of liquid from the second tubular member into the first when the sealing disc 26 is flexed for displacement from sealing engagement with the end of the second tubular member.
  • the rear-, ward end portion of the second tubular member is formed with an outwardly extending flanged portion 28 for use as a finger grip, as will hereinafter be described.
  • the rearward end of the passage 21 is sealed with a rubber plug 30 mounted for axial displacement through the passage 21 as a piston within the cylinder defined by the second tubular member.
  • Means such as a threaded stud 31, is provided on the rearward end of the plug type piston for connection of an actuator 32 for displacement of the piston relative the cylinder.
  • the actuator 32 is in the form of a third elongate tubular member dimensioned to have a cross-section less than the cross-section of the passage 21 through the secondtubular member and formed at one end with an internally threaded female portion 33 for threaded engagement onto the threaded plug 31.
  • the rearward end of the actuator is formed with an outwardly extending flanged portion 34, for use as a finger grip.
  • the actuator is capable of use as a needle cover to protect the needle when other than in position of use and which can be removed from the hub to expose the needle and for attachment to the plug for operation of the device, when in position of use.
  • the element supplies the dual function of a needle protector during non-use and as an actuator in use.
  • fluid 35 is housed in sealing relationship within the second tubular member while the dry medicant is housed in sealing relationship within the first tubular member.
  • the loaded device can be shipped and stored for extended periods of time without deterioration of the ingredients and without exposure of the elements to nonsanitary conditions.
  • the needle cover 32 is removed to expose the needle and the cover is screwed onto the end of the piston plug 30 for use as an actuator.
  • the device is held with the two needle fingers under the flanged members 28 of the second tubular member and the actuator is pressed by the thumb to effect displacement of the plug 30 through the cylindrical passage 21.
  • This operates to place the liquid 35 under pressure which transfers to the resilient closure disc 26 to cause flexure and unset the disc for establishing communication between the chambers 21 and 2 through the openings 27 to enable flow of fluid under pressure from the chamber 21 in the second tubular member into the chamber 2 of the first tubular member for admixture with the dry medicant 36.
  • This intermediate position is illustrated in FIG. 2.
  • the liquid carries the medicant into solution or suspension, with shaking when necessary, to provide a freshly prepared fluid system ready for administration by injection.
  • Administration is made without change of devices and without exposure of the freshly prepared solution or suspension by inserting the needle into the vessel or tissue.
  • the outer casing is grasped with 6 the one hand with the needle fingers beneath the flanged portion 10.
  • the needle is inserted and the hub is compressed to effect relative movement between the needle 15 and the rubber sealing diaphragm 5 whereby the rearward end of the needle punctures the diaphragm to bring the end of the needle into the chamber 2 for direct communication with the freshly prepared liquid system.
  • the thumb is pressed down onto the actuator which, at the end of its travel in the second tubular member, causes displacement of the second tubular member for movement as a piston through the cylindrical passage 2 of the first tubular member thereby forcibly to displace the freshly prepared liquid system from the interior of the first tubular member through the needle and into the tissue.
  • the entire device can be discarded.
  • the sealing disc 26 extends continuously in sealing engagement across the neck of the second tubular member but is provided with a slit which maintains a sealing relationship until opened in response to the application of fluid pressure as the plug 30 is displaced forwardly through the passage 21.
  • a syringe assembly for injection comprising:
  • inner and outer tubular members with the inner member having an outer wall to wall dimension less than the inner wall to wall dimension of the outer tubular member to enable the inner tubular member to be telescoped within the outer tubular member;
  • a flexible closure secured at its outer end portions to a narrow neck portion on the forward end of the inner tubular member with the central portion of said flexible closure normally extending straight across and adjacent the neck portion of the open end of the inner tubular member;
  • a slit in the relatively small central portion of the flexible closure which is not secured to the neck portion and which opens to provide a passage communicating the interior of the inner tubular member with the interior of the outer tubular member in response to pressure from within the inner tubular member, which flexes the central portion of the closure outwardly from its normal straight across position, and which remains in or returns to the normal straight across position to close the passage in the absence of said internal pressure;
  • collapsible means on the forward end portion of the outer tubular member supporting the needle with the rearward end of said needle terminating a short distance in advance of the rupturable closure when in uncollapsed position and penetrating through the rupturable closure when in collapsed position;
  • actuating means for axial displacement of the inner tubular member into the outer tubular member for displacement of fluid from within the outer tubular member.
  • a syringe as claimed in claim 1 which includes a removable cover over the needle.
  • a syringe as claimed in claim 1 in which the inner tubular member is adapted to contain a liquid carrier and in which the outer tubular member is adapted to contain a dry material to be taken up by the liquid carrier when the latter is forced from the inner tubular member into the outer tubular member in response to movement of the piston plug axially in the inner tubular member.
  • a syringe as claimed in claim 1 in which the collapsible means comprises a hub member secured at its rearward end portion onto the forward end of the outer tubular member and a forward end having an opening through which the needle extends with a flexible portion between the ends to enable displacement of the forward end between normal and collapsed position.
  • a syringe as claimed in claim 1 in which the piston ring portion on the forward end of the inner tubular member comprises ring members of rubber-like material in sealing engagement with the outer walls of the inner tubular member and extending into sealing engagement with the inner walls of the outer tubular member.
  • a syringe as claimed in claim 1 in which the piston ring portion and flexible closure are of a unitary construction mounted onto the forward end portion of the inner tubular member.
  • a syringeas claimed in claim 1 in which the piston plug within the inner tubular member is formed of rubber-like material having circular ribs dimensioned to extend into sealing engagement with the inner walls of the inner tubular member.
  • a syringe as claimed in claim 1 wherein said means connected to the piston plug includes an elongate actuator dimensioned to exceed the length of travel of the piston plug through the inner tubular member.
  • a syringe as calimed in claim 8 in which the actuator comprises an elongate rod dimensioned to be received in telescoping relation within the inner tubular member and with means for attachment of the actuator to the piston plug.

Abstract

A syringe device formed of inner and outer tubular members with the inner member adapted to be telescoped within the outer and sealed therefrom by a displaceable seal while the outer member is formed with a rupturable seal having an injection needle in alignment therewith for rupture in use with the inner tubular member adapted to contain a liquid carrier and the outer tubular member a dry medicant to be taken up with the carrier for injection whereby the materials are freshly mixed immediately prior to injection for operation of the device.

Description

0 United States Patent 1191 1111 3,838,689
Cohen Oct. 1, 1974 [54] DISPOSABLE SYRINGE WITH SLIT VALVE 3,301,443 1/1967 Clancy et al 137/5251 1 6 1 1 Inventor Milton Cohen, 7111 connewwt 313331138 31136? $5531 6 8 a1. #53151? -1 Chevy Chase, 20015 3,413,974 12/1968 Cohen 128/218 NV Filedi 5, 1973 FOREIGN PATENTS OR APPLICATIONS [211 Appl 332,643 1,478,062 3/1967 France 128/218 M Related Application Data Primary ExaminerRichardvA. Gaudet [60] Continuation of Ser. No. 86,807, Nov. 4, 1970, A i tant Examiner-J, C, McGowan abandoned, which is a division of Ser. No. 732,622, May 28, 1968, Pat. N0. 3,557,787. A syringe device formed of inner and outer tubular [52] US. Cl. 128/218 M members with the inner member adapted to be tele [51] Int. Cl A6lm 5/22 d h d l d h f b [58] Field 01 Search.,.. 128/218 R, 218 M, 218 NV, y gf i g 128/216, 272, 220, 219; 137/5251 Pacea e w I l "Y" a rupturable seal having an in ection needle in align- [561 1::28218288581855:37:2185:8323823882 UNITED STATES PATENTS outer tubular member a dry medicant to be taken up 2,591,706 4/1952 Lockhart 128/218 M the carrier for injection whereby the materials z; g E gi are freshly mixed immediately prior to injection for am e 3,089,490 5/1963 Goldberg 128/218 NV Operatlo" of the devlce' 3,091,240 5 1963 McConnaughey et al... 128/218 NV 10 Claims, 5 Drawing Figures DISPOSABLE SYRINGE WITH SLIT VALVE This is a continuation, division, of application Ser. No. 86,807, filed Nov. 4, 1970, now abandoned, which is a division of my copending application Ser. No. 732,622, filed May 28, 1968, and entitled A Disposable Syringe, now U.S. Pat. No. 3,557,787, issued Jan. 26, 1971.
This invention'relates to a device for the administration of parenteral solutions and more particularly to a hypodermic syringe adapted to contain dry solids separate and apart from the dissolving or carrier liquids until, immediately prior to administration, the liquid is caused to flow into the compartment containing the solids for injection of the formed mixture.
To the present, it has been the practice to make use of stock solutions housed within a container of relatively large capacity, from which increments can be removed, as desired, for administration by a suitable syringe. This procedure is deemed to be unsatisfactory because most such solutions are of insufficient stability to militate against change before the stock solution has been used up. With a solution of short shelf life, its utility may become dissipated before the solution has been completely utilized.
The most effective means for maintaining the shelf life over extended periods of time is to maintaincomplete separation between the liquid carrier and the solids to be incorporated therein, until immediately prior to use. Maintenance of solid liquid separation until time of use presents other problems with respect to ejecting and administering the solution containing the necessary concentration of ingredients and under the most sanitary conditions. The usual practice is to introduce the solids into the liquid for solution in a suitable container from which the solution can be withdrawn into a syringe for injection. This procedure required the use of at least three separate containers and maintenance under sterile conditions as well as accurate measurement of the ingredients.
It is an object of this invention to provide a single'device in which accurately measured amounts of solid medicants and liquid carrier can be maintained in a completely separated relation, in which the measured amounts of liquid carrier and solid material can be brought together and in which the freshly formed mixture can be injected, all while maintaining the ingredicuts in a sealed and sanitary state, without exposure to the outside atmosphere, and in which the entire operation for mixture and administration can be carried out with one hand.
It is another object to provide a disposable syringe which houses the liquid and solids in separately sealed compartments and in which admixture of the liquid and solid can be effected entirely within the confines of the syringe to make a freshly prepared solution of the measured ingredients and from which the freshly prepared solution can be injected in the manner desired for use.
Other objects and advantages of this invention will hereinafter appear and, for purposes of illustration but not of limitation, an embodiment of the invention is shown in the accompanying drawings in which FIG. 1 is a sectional elevational view of the syringe embodying the features of this invention, with the elements illustrated prior to use;
FIG. 2 is a sectional elevational .view of the syringe shown in FIG. I with the syringe partially'actuated to effect displacement of the liquid carrier from the liguid chamber to the solids chamber for solution or admixture;
FIG. 3 is a sectional elevational view of the syringe shown in FIGS. 1 and 2 with the syringe in fully actuated position to effect displacement of the freshly prepared solution from the solids compartment for injection; 1
FIG. 4 is a sectional elevational view of a portion of the syringe shown in FIGS. 1 to 3 and showing a modification in the closure for the liquid containing compartment; and
FIG. 5 is a sectional elevational view of the actuator which may also be used as a needle cover.
With reference now to the drawings, the syringe of this invention is formed with an outer casing l in the form of a tubular member, formed of glass, plastic or the like, having a continuous bore 2 extending therethrough from an open rearward end portion 3 to a neck portion 4 of smaller cross-section, at the forward end. The forward end is sealed by means of a disc member 5 held in place in sealing relationship across the open neck 6 of the tubular member I by means of a metal cap 7 which is crimped about the outer neck end portion of the tubular member while the inner portions 8 of the cap overlap the outer edge portions of the sealing disc member overlying the flattened end surface 9 of the tubular member. The rearward end of the tubular member is formed with an outwardly extending annular flange 10 which serves as a finger grip. A hub member 11 has a skirt portion 12 crimped about the skirt portion of the cap for securing the hub onto the neck end portion of the tubular member. The hub is also formed with an intermediate collapsible or corrugated portion 13 extending forwardly in axial alignment with the forward end of the tubular member with a hub 14 on the forward end through which a hollow needle 15 extends with a sharpened end portion of the needle projecting into the interior of the hub member 11 for a distance less than the spaced relationship between the hub end and the diaphragm 5, when in normal position, thereby to locate the rearward end of the needle immediately in advance of the center of the diaphragm.
A second tubular member of glass, plastic or the like material is dimensioned to have an outer wall to wall dimension which is less than the inner wall to wall dimension of the tubular member 1 to enable the former to be telescoped through the interior of the outer tubular member 1. The second tubular member is similarly formed with a passage 21 extending from the open rearward end 22 through a neck portion 23 of smaller cross-section at the forward end. The forward neck end portion of the second tubular member is fitted with a rubber stopper 24 including an outer ribbed portion 25 fitted in gripping relationship about the neck and extending laterally beyond the walls of the second tubular member for a distance to effect sealing engagement with the inner walls of the outer tubular member 1 whereby the second tubular member is capable of the function of a piston movable axially relative the outer tubular member 1 thereby to provide a piston andcylinder arrangement between the two tubular members.
The rubber stopper 25 has a disc portion 26 which normally spans the forward end of the passage to seal the tubular member. It is further formed with one or more openings 27 in the lateral portions beyond the passage to enable flow of liquid from the second tubular member into the first when the sealing disc 26 is flexed for displacement from sealing engagement with the end of the second tubular member. Again, the rear-, ward end portion of the second tubular member is formed with an outwardly extending flanged portion 28 for use as a finger grip, as will hereinafter be described. The rearward end of the passage 21 is sealed with a rubber plug 30 mounted for axial displacement through the passage 21 as a piston within the cylinder defined by the second tubular member. Means, such as a threaded stud 31, is provided on the rearward end of the plug type piston for connection of an actuator 32 for displacement of the piston relative the cylinder. In the illustrated modification, the actuator 32 is in the form of a third elongate tubular member dimensioned to have a cross-section less than the cross-section of the passage 21 through the secondtubular member and formed at one end with an internally threaded female portion 33 for threaded engagement onto the threaded plug 31. The rearward end of the actuator is formed with an outwardly extending flanged portion 34, for use as a finger grip.
In the modification shown in FIG. 5, the actuator is capable of use as a needle cover to protect the needle when other than in position of use and which can be removed from the hub to expose the needle and for attachment to the plug for operation of the device, when in position of use. Thus the element supplies the dual function of a needle protector during non-use and as an actuator in use.
In the assembled relation, illustrated in FIG. 1, fluid 35 is housed in sealing relationship within the second tubular member while the dry medicant is housed in sealing relationship within the first tubular member. The loaded device can be shipped and stored for extended periods of time without deterioration of the ingredients and without exposure of the elements to nonsanitary conditions.
In use, the needle cover 32 is removed to expose the needle and the cover is screwed onto the end of the piston plug 30 for use as an actuator. The device is held with the two needle fingers under the flanged members 28 of the second tubular member and the actuator is pressed by the thumb to effect displacement of the plug 30 through the cylindrical passage 21. This operates to place the liquid 35 under pressure which transfers to the resilient closure disc 26 to cause flexure and unset the disc for establishing communication between the chambers 21 and 2 through the openings 27 to enable flow of fluid under pressure from the chamber 21 in the second tubular member into the chamber 2 of the first tubular member for admixture with the dry medicant 36. This intermediate position is illustrated in FIG. 2. The liquid carries the medicant into solution or suspension, with shaking when necessary, to provide a freshly prepared fluid system ready for administration by injection.
Administration is made without change of devices and without exposure of the freshly prepared solution or suspension by inserting the needle into the vessel or tissue. For this purpose, the outer casing is grasped with 6 the one hand with the needle fingers beneath the flanged portion 10. The needle is inserted and the hub is compressed to effect relative movement between the needle 15 and the rubber sealing diaphragm 5 whereby the rearward end of the needle punctures the diaphragm to bring the end of the needle into the chamber 2 for direct communication with the freshly prepared liquid system. Thereafter, the thumb is pressed down onto the actuator which, at the end of its travel in the second tubular member, causes displacement of the second tubular member for movement as a piston through the cylindrical passage 2 of the first tubular member thereby forcibly to displace the freshly prepared liquid system from the interior of the first tubular member through the needle and into the tissue.
Upon administration of the freshly prepared solution, the entire device can be discarded.
In the modification shown in FIG. 4, the sealing disc 26 extends continuously in sealing engagement across the neck of the second tubular member but is provided with a slit which maintains a sealing relationship until opened in response to the application of fluid pressure as the plug 30 is displaced forwardly through the passage 21.
It will be apparent from the foregoing that I have provided a simple disposable syringe capable of operation with one hand in which liquids and solids are maintained in separately sealed chambers and mixed immediately prior to injection by a simple operation of the device.
It will be understood that changes may be made in the details of construction, arrangement and operation without departing from the spirit of the invention, especially as defined in the following claims.
I claim:
1. A syringe assembly for injection comprising:
inner and outer tubular members with the inner member having an outer wall to wall dimension less than the inner wall to wall dimension of the outer tubular member to enable the inner tubular member to be telescoped within the outer tubular member;
a rupturable closure sealing the forward end of the outer tubular member;
a flexible closure secured at its outer end portions to a narrow neck portion on the forward end of the inner tubular member with the central portion of said flexible closure normally extending straight across and adjacent the neck portion of the open end of the inner tubular member;
a slit in the relatively small central portion of the flexible closure which is not secured to the neck portion and which opens to provide a passage communicating the interior of the inner tubular member with the interior of the outer tubular member in response to pressure from within the inner tubular member, which flexes the central portion of the closure outwardly from its normal straight across position, and which remains in or returns to the normal straight across position to close the passage in the absence of said internal pressure;
a piston ring portion on the forward end of the inner tubular member in sliding engagement with the inner walls of the outer tubular member;
a piston plug slidably received within the inner tubu lar member in sealing engagement with the inner wall of the inner tubular member;
means connected to the piston plug and extending rearwardly beyond the inner tubular member for actuating the piston plug axially relative to the inner tubular member;
a hypodermic needle;
collapsible means on the forward end portion of the outer tubular member supporting the needle with the rearward end of said needle terminating a short distance in advance of the rupturable closure when in uncollapsed position and penetrating through the rupturable closure when in collapsed position; and
actuating means for axial displacement of the inner tubular member into the outer tubular member for displacement of fluid from within the outer tubular member.
2. A syringe as claimed in claim 1 which includes a removable cover over the needle.
3. A syringe as claimed in claim 1 in which the inner tubular member is adapted to contain a liquid carrier and in which the outer tubular member is adapted to contain a dry material to be taken up by the liquid carrier when the latter is forced from the inner tubular member into the outer tubular member in response to movement of the piston plug axially in the inner tubular member.
4. A syringe as claimed in claim 1 in which the collapsible means comprises a hub member secured at its rearward end portion onto the forward end of the outer tubular member and a forward end having an opening through which the needle extends with a flexible portion between the ends to enable displacement of the forward end between normal and collapsed position.
5. A syringe as claimed in claim 1 in which the piston ring portion on the forward end of the inner tubular member comprises ring members of rubber-like material in sealing engagement with the outer walls of the inner tubular member and extending into sealing engagement with the inner walls of the outer tubular member.
6. A syringe as claimed in claim 1 in which the piston ring portion and flexible closure are of a unitary construction mounted onto the forward end portion of the inner tubular member.
7. A syringeas claimed in claim 1 in which the piston plug within the inner tubular member is formed of rubber-like material having circular ribs dimensioned to extend into sealing engagement with the inner walls of the inner tubular member.
8. A syringe as claimed in claim 1 wherein said means connected to the piston plug includes an elongate actuator dimensioned to exceed the length of travel of the piston plug through the inner tubular member.
9. A syringe as calimed in claim 8 in which the actuator comprises an elongate rod dimensioned to be received in telescoping relation within the inner tubular member and with means for attachment of the actuator to the piston plug.
10. A syringe as claimed in claim 1 wherein said actuating means includes flanged members extending radially outwardly from the rearward end portions of the inner and outer tubular members for use as finger gripsv

Claims (10)

1. A syringe assembly for injection comprising: inner and outer tubular members with the inner member having an outer wall to wall dimension less than the inner wall to wall dimension of the outer tubular member to enable the inner tubular member to be telescoped within the outer tubular member; a rupturable closure sealing the forward end of the outer tubular member; a flexible closure secured at its outer end portions to a narrow neck portion on the forward end of the inner tubular member with the central portion of said flexible closure normally extending straight across and adjacent the neck portion of the open end of the inner tubular member; a slit in the relatively small central portion of the flexible closure which is not secured to the neck portion and which opens to provide a passage communicating the interior of the inner tubular member with the interior of the outer tubular member in response to pressure from within the inner tubular member, which flexes the central portion of the closure outwardly from its normal straight across position, and which remains in or returns to the normal straight across position to close the passage in the absence of said internal pressure; a piston ring portion on the forward end of the inner tubular member in sliding engagement with the inner walls of the outer tubular member; a piston plug slidably received within the inner tubular member in sealing engagement with the inner wall of the inner tubular member; means connected to the piston plug and extending rearwardly beyond the inner tubular member for actuating the piston plug axially relative to the inner tubular member; a hypodermic needle; collapsible means on the forward end portion of the outer tubular member supporting the needle with the rearward end of said needle terminating a short distance in advance of the rupturable closure when in uncollapsed position and penetrating through the rupturable closure when in collapsed position; and actuating means for axial displacement of the inner tubular member into the outer tubular member for displacement of fluid from within the outer tubular member.
2. A syringe as claimed in claim 1 which includes a removable cover over the needle.
3. A syringe as claimed in claim 1 in which the inner tubular member is adapted to contain a liquid carrier and in which the outer tubular member is adapted to contain a dry material to be taken up by the liquid carrier when the latter is forced from the inner tubular member into the outer tubular member in response to movement of the piston plug axially in the inner tubular member.
4. A syringe as claimed in claim 1 in which the collapsible means comprises a hub member secured at its rearward end portion onto the forward end of the outer tubular member and a forward end having an opening through which the needle extends with a flexibLe portion between the ends to enable displacement of the forward end between normal and collapsed position.
5. A syringe as claimed in claim 1 in which the piston ring portion on the forward end of the inner tubular member comprises ring members of rubber-like material in sealing engagement with the outer walls of the inner tubular member and extending into sealing engagement with the inner walls of the outer tubular member.
6. A syringe as claimed in claim 1 in which the piston ring portion and flexible closure are of a unitary construction mounted onto the forward end portion of the inner tubular member.
7. A syringe as claimed in claim 1 in which the piston plug within the inner tubular member is formed of rubber-like material having circular ribs dimensioned to extend into sealing engagement with the inner walls of the inner tubular member.
8. A syringe as claimed in claim 1 wherein said means connected to the piston plug includes an elongate actuator dimensioned to exceed the length of travel of the piston plug through the inner tubular member.
9. A syringe as calimed in claim 8 in which the actuator comprises an elongate rod dimensioned to be received in telescoping relation within the inner tubular member and with means for attachment of the actuator to the piston plug.
10. A syringe as claimed in claim 1 wherein said actuating means includes flanged members extending radially outwardly from the rearward end portions of the inner and outer tubular members for use as finger grips.
US00332643A 1970-11-04 1973-02-15 Disposable syringe with slit valve Expired - Lifetime US3838689A (en)

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US3980083A (en) * 1975-02-13 1976-09-14 Illinois Tool Works Inc. Medicament infusor unit
US4041945A (en) * 1976-06-07 1977-08-16 Guiney Aeneas C Mixing syringe
US4331146A (en) * 1976-12-23 1982-05-25 The West Company Syringe assembly
US4412836A (en) * 1979-04-27 1983-11-01 The West Company, Incorporated Syringe assembly
US4507113A (en) * 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
US4643721A (en) * 1984-11-20 1987-02-17 Poutrait-Morin Multiple compartment ampule for automatic hypodermic syringes
EP0511183A1 (en) * 1991-04-25 1992-10-28 Kabi Pharmacia AB Injection container
EP0545324A1 (en) * 1991-11-29 1993-06-09 Sergej Mikhailovic Masurik Injection syringe
US5286257A (en) * 1992-11-18 1994-02-15 Ultradent Products, Inc. Syringe apparatus with detachable mixing and delivery tip
WO1996029106A2 (en) * 1995-03-22 1996-09-26 Abbott Laboratories Pre-filled syringe drug delivery system
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5702019A (en) * 1995-09-27 1997-12-30 Becton Dickinson France S.A. Vial having resealable membrane assembly activated by a medical delivery device
EP0821975A1 (en) * 1996-07-31 1998-02-04 Novartis AG (Novartis SA) (Novartis Inc.) Dosing device for fluids
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5779668A (en) * 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5871110A (en) * 1996-09-13 1999-02-16 Grimard; Jean-Pierre Transfer assembly for a medicament container having a splashless valve
US5873872A (en) * 1996-09-17 1999-02-23 Becton Dickinson And Company Multipositional resealable vial connector assembly for efficient transfer of liquid
US5876372A (en) * 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5925029A (en) * 1997-09-25 1999-07-20 Becton, Dickinson And Company Method and apparatus for fixing a connector assembly onto a vial with a crimp cap
US6003702A (en) * 1995-09-27 1999-12-21 Becton Dickinson France, S.A. Vial with resealable connector assembly having a membrane and a multi-configuration fluid access device
US6003566A (en) * 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
US6090093A (en) * 1997-09-25 2000-07-18 Becton Dickinson And Company Connector assembly for a vial having a flexible collar
US6168037B1 (en) * 1995-09-27 2001-01-02 Becton Dickinson France, S.A. Resealable vial with connector assembly having a membrane and pusher
US6209738B1 (en) 1998-04-20 2001-04-03 Becton, Dickinson And Company Transfer set for vials and medical containers
US6213994B1 (en) 1997-09-25 2001-04-10 Becton Dickinson France, S.A. Method and apparatus for fixing a connector assembly onto a vial
US6378714B1 (en) 1998-04-20 2002-04-30 Becton Dickinson And Company Transferset for vials and other medical containers
US6382442B1 (en) 1998-04-20 2002-05-07 Becton Dickinson And Company Plastic closure for vials and other medical containers
US20030088216A1 (en) * 2001-10-03 2003-05-08 Daniel Py Syringe and reconstitution syringe
US20030089743A1 (en) * 2001-10-16 2003-05-15 Daniel Py Dispenser with sealed chamber and one-way valve for providing metered amounts of substances
US6681946B1 (en) 1998-02-26 2004-01-27 Becton, Dickinson And Company Resealable medical transfer set
US20050075613A1 (en) * 2003-06-27 2005-04-07 Mitsuru Hasegawa Displaceable-plug-containing filling/discharging port and medical container having the same
US6904662B2 (en) 1998-04-20 2005-06-14 Becton, Dickinson And Company Method of sealing a cartridge or other medical container with a plastic closure
US20050177100A1 (en) * 2003-10-24 2005-08-11 Harper Derek J. Dual chamber mixing syringe and method for use
US6957745B2 (en) 1998-04-20 2005-10-25 Becton, Dickinson And Company Transfer set
US20060144869A1 (en) * 2004-12-30 2006-07-06 Chang Byeong S Container closure delivery system
US20060157507A1 (en) * 2004-12-30 2006-07-20 Chang Byeong S Multi-functional container closure delivery system
US7226231B2 (en) 2003-07-17 2007-06-05 Medical Instill Technologies, Inc. Piston-type dispenser with one-way valve for storing and dispensing metered amounts of substances
US7264142B2 (en) 2004-01-27 2007-09-04 Medical Instill Technologies, Inc. Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
US20070225640A1 (en) * 2004-12-30 2007-09-27 Chang Byeong S Container closure delivery system
US20080146998A1 (en) * 2004-08-02 2008-06-19 Bertron Kim W Powder and liquid mixing syringe
US7503907B1 (en) 1999-10-22 2009-03-17 Antares Pharma, Inc. Medicament cartridge and injection device
US20100030159A1 (en) * 2007-06-11 2010-02-04 Jian-Xin Li Syringe plunger
US20100063474A1 (en) * 2008-09-10 2010-03-11 Thomasevans, LLC Multi-chambered mixing syringe device and methods of use
US7798185B2 (en) 2005-08-01 2010-09-21 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile food product
US7861750B2 (en) 2003-05-12 2011-01-04 Medical Instill Technologies, Inc. Dispenser and apparatus and method of filling a dispenser
US7887506B1 (en) * 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US8425453B2 (en) 2004-12-30 2013-04-23 Integrity Bio, Inc. Compact medication reconstitution device and method
US20140228746A1 (en) * 2012-06-26 2014-08-14 Glucago, Llc Reconstitution device
US20140254303A1 (en) * 2012-01-23 2014-09-11 Merit Medical Systems, Inc. Mixing syringe
US9125995B2 (en) 2012-12-05 2015-09-08 Glucago Llc Reconstitution devices
US9149581B2 (en) 2009-03-09 2015-10-06 Glucago Llc Compact device for rapidly mixing and delivering substances to a patient
US9408455B2 (en) 2002-08-13 2016-08-09 MedInstill Development, LLC Container and valve assembly for storing and dispensing substances, and related method
US10201692B2 (en) 2014-09-09 2019-02-12 Byeong Seon Chang Solution delivery device and method
US10786433B2 (en) * 2017-09-13 2020-09-29 William J Moore Buffering agent cartridge
US20210227950A1 (en) * 2018-05-23 2021-07-29 L'oreal Device for preparing a cosmetic composition and associated process

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Cited By (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980083A (en) * 1975-02-13 1976-09-14 Illinois Tool Works Inc. Medicament infusor unit
US4041945A (en) * 1976-06-07 1977-08-16 Guiney Aeneas C Mixing syringe
US4331146A (en) * 1976-12-23 1982-05-25 The West Company Syringe assembly
US4412836A (en) * 1979-04-27 1983-11-01 The West Company, Incorporated Syringe assembly
US4507113A (en) * 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
US4643721A (en) * 1984-11-20 1987-02-17 Poutrait-Morin Multiple compartment ampule for automatic hypodermic syringes
EP0511183A1 (en) * 1991-04-25 1992-10-28 Kabi Pharmacia AB Injection container
WO1992019295A1 (en) * 1991-04-25 1992-11-12 Kabi Pharmacia Ab Injection container
US5354285A (en) * 1991-11-29 1994-10-11 Sergej Mikhailovich Masurik Injection syringe
EP0545324A1 (en) * 1991-11-29 1993-06-09 Sergej Mikhailovic Masurik Injection syringe
US5286257A (en) * 1992-11-18 1994-02-15 Ultradent Products, Inc. Syringe apparatus with detachable mixing and delivery tip
US5919159A (en) * 1995-01-09 1999-07-06 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5846233A (en) * 1995-01-09 1998-12-08 Medi-Ject Corporation Coupling device for medical injection system
US5891085A (en) * 1995-01-09 1999-04-06 Medi-Ject Corporation Nozzle assembly with lost motion connection for medical injector assembly
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
WO1996029106A3 (en) * 1995-03-22 1996-10-24 Abbott Lab Pre-filled syringe drug delivery system
WO1996029106A2 (en) * 1995-03-22 1996-09-26 Abbott Laboratories Pre-filled syringe drug delivery system
AU696759B2 (en) * 1995-03-22 1998-09-17 Abbott Laboratories Pre-filled syringe drug delivery system
US5876372A (en) * 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5779668A (en) * 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US5702019A (en) * 1995-09-27 1997-12-30 Becton Dickinson France S.A. Vial having resealable membrane assembly activated by a medical delivery device
US6003702A (en) * 1995-09-27 1999-12-21 Becton Dickinson France, S.A. Vial with resealable connector assembly having a membrane and a multi-configuration fluid access device
US6168037B1 (en) * 1995-09-27 2001-01-02 Becton Dickinson France, S.A. Resealable vial with connector assembly having a membrane and pusher
US5800388A (en) * 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5722953A (en) * 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5643211A (en) * 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5697917A (en) * 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5921967A (en) * 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
EP0821975A1 (en) * 1996-07-31 1998-02-04 Novartis AG (Novartis SA) (Novartis Inc.) Dosing device for fluids
US6161731A (en) * 1996-07-31 2000-12-19 Novartis Ag Dosing device
US5871110A (en) * 1996-09-13 1999-02-16 Grimard; Jean-Pierre Transfer assembly for a medicament container having a splashless valve
US5873872A (en) * 1996-09-17 1999-02-23 Becton Dickinson And Company Multipositional resealable vial connector assembly for efficient transfer of liquid
US5875976A (en) * 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5925029A (en) * 1997-09-25 1999-07-20 Becton, Dickinson And Company Method and apparatus for fixing a connector assembly onto a vial with a crimp cap
US6090093A (en) * 1997-09-25 2000-07-18 Becton Dickinson And Company Connector assembly for a vial having a flexible collar
US6213994B1 (en) 1997-09-25 2001-04-10 Becton Dickinson France, S.A. Method and apparatus for fixing a connector assembly onto a vial
US6681946B1 (en) 1998-02-26 2004-01-27 Becton, Dickinson And Company Resealable medical transfer set
US6003566A (en) * 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
US6189580B1 (en) 1998-02-26 2001-02-20 Becton, Dickinson And Company Vial transferset and method
US6378576B2 (en) 1998-02-26 2002-04-30 Becton Dickinson And Company Vial transferset and method
US6945417B2 (en) 1998-02-26 2005-09-20 Becton, Dickinson And Company Resealable medical transfer set
US6957745B2 (en) 1998-04-20 2005-10-25 Becton, Dickinson And Company Transfer set
US6378714B1 (en) 1998-04-20 2002-04-30 Becton Dickinson And Company Transferset for vials and other medical containers
US6209738B1 (en) 1998-04-20 2001-04-03 Becton, Dickinson And Company Transfer set for vials and medical containers
US6571837B2 (en) 1998-04-20 2003-06-03 Becton Dickinson France S.A. Transfer set for vials and medical containers
US6626309B1 (en) 1998-04-20 2003-09-30 Becton Dickinson France S.A. Transfer set
US6382442B1 (en) 1998-04-20 2002-05-07 Becton Dickinson And Company Plastic closure for vials and other medical containers
US6904662B2 (en) 1998-04-20 2005-06-14 Becton, Dickinson And Company Method of sealing a cartridge or other medical container with a plastic closure
US7503907B1 (en) 1999-10-22 2009-03-17 Antares Pharma, Inc. Medicament cartridge and injection device
US7887506B1 (en) * 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US7186241B2 (en) 2001-10-03 2007-03-06 Medical Instill Technologies, Inc. Syringe with needle penetrable and laser resealable stopper
US20030088216A1 (en) * 2001-10-03 2003-05-08 Daniel Py Syringe and reconstitution syringe
US7779609B2 (en) 2001-10-03 2010-08-24 Medical Instill Technologies, Inc. Method of filling a device
US8220507B2 (en) 2001-10-16 2012-07-17 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile product
US20030089743A1 (en) * 2001-10-16 2003-05-15 Daniel Py Dispenser with sealed chamber and one-way valve for providing metered amounts of substances
US9630755B2 (en) 2001-10-16 2017-04-25 Medinstill Development Llc Dispenser and method for storing and dispensing sterile product
US7290573B2 (en) 2001-10-16 2007-11-06 Medical Instill Technologies, Inc. Dispenser with sealed chamber, one-way valve and needle penetrable and laser resealable stopper
US9408455B2 (en) 2002-08-13 2016-08-09 MedInstill Development, LLC Container and valve assembly for storing and dispensing substances, and related method
US9963288B2 (en) 2003-05-12 2018-05-08 Maej Llc Dispenser and apparatus and method for filling a dispenser
US8627861B2 (en) 2003-05-12 2014-01-14 Medical Instill Technologies, Inc. Dispenser and apparatus and method for filling a dispenser
US7861750B2 (en) 2003-05-12 2011-01-04 Medical Instill Technologies, Inc. Dispenser and apparatus and method of filling a dispenser
US7207970B2 (en) * 2003-06-27 2007-04-24 Nipro Corporation Displaceable-plug-containing filling/discharging port and medical container having the same
US20050075613A1 (en) * 2003-06-27 2005-04-07 Mitsuru Hasegawa Displaceable-plug-containing filling/discharging port and medical container having the same
US8240934B2 (en) 2003-07-17 2012-08-14 Medical Instill Technologies, Inc. Dispenser with one-way valve for storing and dispensing substances
US7651291B2 (en) 2003-07-17 2010-01-26 Medical Instill Technologies, Inc. Dispenser with one-way valve for storing and dispensing metered amounts of substances
US9440773B2 (en) 2003-07-17 2016-09-13 Medinstill Development Llc Device with one-way valve
US7226231B2 (en) 2003-07-17 2007-06-05 Medical Instill Technologies, Inc. Piston-type dispenser with one-way valve for storing and dispensing metered amounts of substances
US20090018496A1 (en) * 2003-10-24 2009-01-15 Mdc Investment Holdings, Inc. Dual chamber mixing syringe and method for use
US7951108B2 (en) 2003-10-24 2011-05-31 Mdc Investment Holdings, Inc. Dual chamber mixing syringe and method for use
US20050177100A1 (en) * 2003-10-24 2005-08-11 Harper Derek J. Dual chamber mixing syringe and method for use
US7886937B2 (en) 2004-01-27 2011-02-15 Medical Instill Technologies, Inc. Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US8413854B2 (en) 2004-01-27 2013-04-09 Medical Instill Technologies, Inc. Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US7264142B2 (en) 2004-01-27 2007-09-04 Medical Instill Technologies, Inc. Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
US9377338B2 (en) 2004-01-27 2016-06-28 Medinstill Development Llc Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US8919614B2 (en) 2004-01-27 2014-12-30 Medinstill Development Llc Dispenser with variable-volume storage chamber, one-way valve, and manually-depressible actuator
US7644842B2 (en) 2004-01-27 2010-01-12 Medical Instill Technologies, Inc. Dispenser having variable-volume storage chamber and depressible one-way valve assembly for dispensing creams and other substances
US7967779B2 (en) * 2004-08-02 2011-06-28 Bertron Kim W Powder and liquid mixing syringe
US20080146998A1 (en) * 2004-08-02 2008-06-19 Bertron Kim W Powder and liquid mixing syringe
US20060144869A1 (en) * 2004-12-30 2006-07-06 Chang Byeong S Container closure delivery system
US8425453B2 (en) 2004-12-30 2013-04-23 Integrity Bio, Inc. Compact medication reconstitution device and method
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US10624815B2 (en) 2004-12-30 2020-04-21 Byeong Seon Chang Compact medication reconstitution device and method
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US7959600B2 (en) 2004-12-30 2011-06-14 Byeong S. Chang Container closure delivery system
US9463139B2 (en) 2004-12-30 2016-10-11 Byeong Seon Chang Compact medication reconstitution device and method
US10105285B2 (en) 2004-12-30 2018-10-23 Byeong Seon Chang Compact medication reconstitution device and method
US9174002B2 (en) 2004-12-30 2015-11-03 Byeong S. Chang Method for storing and delivering a drug
US7798185B2 (en) 2005-08-01 2010-09-21 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile food product
US20100030159A1 (en) * 2007-06-11 2010-02-04 Jian-Xin Li Syringe plunger
US8353866B2 (en) 2008-09-10 2013-01-15 Thomasevans, LLC Multi-chambered mixing syringe device and methods of use
US20100063474A1 (en) * 2008-09-10 2010-03-11 Thomasevans, LLC Multi-chambered mixing syringe device and methods of use
US9149581B2 (en) 2009-03-09 2015-10-06 Glucago Llc Compact device for rapidly mixing and delivering substances to a patient
US20140254303A1 (en) * 2012-01-23 2014-09-11 Merit Medical Systems, Inc. Mixing syringe
US9751056B2 (en) * 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
US8992469B2 (en) * 2012-06-26 2015-03-31 Glucago Llc Reconstitution device
US20140228746A1 (en) * 2012-06-26 2014-08-14 Glucago, Llc Reconstitution device
US9125995B2 (en) 2012-12-05 2015-09-08 Glucago Llc Reconstitution devices
US10201692B2 (en) 2014-09-09 2019-02-12 Byeong Seon Chang Solution delivery device and method
US10894152B2 (en) 2014-09-09 2021-01-19 Byeong Seon Chang Solution delivery device and method
US10786433B2 (en) * 2017-09-13 2020-09-29 William J Moore Buffering agent cartridge
US11241364B2 (en) * 2017-09-13 2022-02-08 William J Moore Buffering agent cartridge
US20210227950A1 (en) * 2018-05-23 2021-07-29 L'oreal Device for preparing a cosmetic composition and associated process

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