US3890204A - Culture collecting package - Google Patents

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US3890204A
US3890204A US509706A US50970674A US3890204A US 3890204 A US3890204 A US 3890204A US 509706 A US509706 A US 509706A US 50970674 A US50970674 A US 50970674A US 3890204 A US3890204 A US 3890204A
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ampoule
culture
end portion
package
media
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US509706A
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Carl Frederick Avery
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Becton Dickinson and Co
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Marion Health and Safety Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/02—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by impregnation, e.g. using swabs or loops
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/22—Means for packing or storing viable microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/028—Sampling from a surface, swabbing, vaporising
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Definitions

  • This invention relates to devices used by physicians and the like for collecting a culture from various areas of a patients body and for keeping the culture alive for a period of time after it has been collected.
  • Such devices customarily include an absorbent swab upon which the culture is collected by swabbing a particular body area. and further include a container having its own supply of culture-sustaining media. After the culture has been collected.
  • the swab is placed into the container and in contact with the media so as to keep the culture alive until it is subsequently tested.
  • Devices of this general type are disclosed in Pickering US. Pat. No. 3.579.303; Aronoff, et al., US. Pat. No. 3.773.035; Henshilwood. et al.. U.S. Pat. No. 3.783.104 and Henshilwood US Pat. No. 3.783.106.
  • Such a device includes a flexible outer tube within which is retained a frangible glass ampoule having a liquid culture-sustaining media sealed therein. After a culture has been collected on a swab. the latter is placed into the tube and the tube is squeezed to break the ampoule and release the liquid. The liquid moistens an absorbent plug which is disposed within the tube in engagement with the tip of the swab so as to keep the latter moist until the culture is tested.
  • culture collecting device is attributable to the fact that the culture-sustaining media is originally sealed within an ampoule made ofglass.
  • the glass ampoule can be easily and effectively sterilized with steam and it does not react either with the culturesustaining media or the culture.
  • One of the primary aims of the present invention is to provide a new and improved culture collecting device which retains all of the basic advantages of the prior Avery. et al.. device while being simpler in con struction. easier to use. and more readily adaptable to collect and sustain different types of cultures.
  • a further object is to provide a comparatively simple and inexpensive culture collecting device which may employ either a liquid or solid culture-sustaining media and which is capable of maintaining the culture in a substantially oxygen-free atmosphere.
  • a more detailed object is to provide a culture collecting device having a unique glass ampoule which not only holds the culture-sustaining media but which also serves as a container for the swab after the culture has been taken.
  • the invention also resides in the novel construction of the ampoule to facilitate the gaining of access to the culture-sustaining media.
  • FIG. I is a perspective view of a new and improved culture collecting package embodying the novel features of the present invention.
  • FIG. 2 is a perspective view of the ampoule.
  • FIG. 3 is a perspective view of the swab.
  • FIG. 4 is a cross-section taken along the line 4-4 of FIG. 3.
  • FIG. 5 is a perspective view showing the ampoule being opened to enable access to the culture-sustaining media.
  • FIG. 6 is a perspective view showing the swab telescoped with the ampoule.
  • the invention is embodied in a package 10 whose components are used for collecting a bacterial specimen or culture from a patient's body and for maintaining the culture in a live condition until such time as it can be tested.
  • the present invention contemplates the provision ofa culture collecting package having new and improved components which are simpler, less expensive and easier to use than those available heretofore and which are capable of maintaining the collected culture in either a normal or an oxygen-free atmosphere while preserving the culture in either a liquid or solid culturesustaining media.
  • the package 10 includes a swab II and an ampoule 13 which initially are disposed side-byside within an elongated and substantially flat envelope 14.
  • the latter comprises a flexible transparent blister 15 which is releasably sealed to a peel away backing 16.
  • the envelope may be autoclaved in order to sterilize the swab and the outside of the ampoule.
  • the swab and the ampoule may be removed from the envelope by peeling away one end portion of the backing 16 and taking the swab and ampoule out of the opened end of the envelope.
  • the swab 11 comprises an elongated stem 17 (FIG. 3) made of plastic and having an absorbent swabbing tip 19 such as cotton on one end thereof. After a culture has been collected on the tip, it is necessary to place the tip in contact with a culture-sustaining media 20 in order to keep the culture in a live condition until it reaches a laboratory for testing.
  • the culture-sustaining media 20 is originally sealed within the ampoule l3 which advantageously is made of glass and which serves as a container for the swab 11 after the culture has been collected.
  • the ampoule is of one-piece construction and includes an elongated tubular body 21 having a circular cross-section and having ends which are defined by generally hemi-spherical domes 23 and 24.
  • the culture-sustaining media 20 is disposed within one end portion of the ampoule and. in this instance. is shown as being a liquid such as modified Stuarts transport media.
  • the culture-sustaining media can. however.
  • the ampoule also will be 3 filled with a non-oxidizing and preferably headuchanair gas such as nitrogen.
  • the ampoule 13 is opened to permit the tip to he placed in contact with the media 20.
  • a circumferentially extending score line (FIG 2) is scratched in the outside of the ampoule body 21 adjacent the dome 24, the score line being comparatively short and extending only part way around the circumference of the body.
  • a band of tape 26 (FIG. 2) with printed instructions may be wrapped around the body 21, the tape having end portions overlapping the end portions of the ampoule and having a perforated tear line 27 alined with the score line 25.
  • a closure or cap 30 (FIG. 3) is joined to the end of the stem 17 opposite the tip 19 and is sized to telescope tightly over the open end portion of the ampoule.
  • the cap is made of plastic and includes a series of axially extending ribs 31 (FIG. 4) which are spaced circumferentially around the interior of the cap and which tightly grip the swab stem 17.
  • the ampoule 11 may be replaced in the envelope l4 and delivered to the laboratory for testing of the culture on the swab tip 19.
  • the ampoule 11 is effected much in the same way as the ampoule disclosed in the aforementioned Avery, et al.. patent. That is. one end portion of the body 21 is flamed over to form the dome 23 and then the culture-sustaining media 20 is inserted into the ampoule along with a nonoxidizing gas if the latter is desired. Thereafter, the other end portion of the body is flamed over to form the dome 24 and seal the media within the ampoule. Filling and sealing of the ampoule are effected under sterile conditions and thus the interior of the ampoule is sterile when the ampoule is packaged in the envelope 14.
  • the present invention brings to the art a new and improved culture collecting device which possesses the basic advan tages of the commercially successful Avery, et al., device presently being marketed and provides several additional advantages. That is, the new device does not require an outer plastic tube nor an absorbent plug. There is no danger of glass fragments from a crushed ampoule collecting on the swab tip or piercing through an outer tube. The new device is capable of using both solid and liquid culture-sustaining media and of maintaining the culture in an oxygen-free atmosphere. Moreover.
  • the cap 30 may be made shorter since the swab ll assumes only a single position within the ampoule 13 rather than a pre-collecting position and a dif ferent post-collecting position as in the case of the swab within the outer tube of the prior Avery. et al., device.
  • a culture collecting package said package including a sealed one-piece ampoule made of glass, said ampoule having an elongated tubular body of circular cross-section and having domed ends, a culturesustaining media contained within said ampoule, and a circumferentially extending score line formed in said body whereby one end portion of the ampoule may be broken away from the other end portion along said score line to allow access to said media, said package further including a swab comprising an elongated stern, a swabbing tip on one end of said stern. and a closure on the other end of said stem and sized to telescope with and close the open end of said other end portion of said ampoule after a culture has been collected on said tip and the latter has been placed in contact with said media.
  • a culture collecting package as defined in claim 1 including an elongated envelope, said ampoule and said swab being disposed side-by-side within said envelope prior to initial opening of the envelope.
  • a culture collecting package as defined in claim I in which said score line extends only part way around the circumference of said body. and further including a flexible band wrapped around said body and covering said score line, one end portion of said band extending around one end portion of said ampoule and the other end portion of said band extending around the other end portion of said ampoule, at least one end portion of said band being secured to the corresponding end portion of said ampoule, and a circumferentially extending tear line formed around said band and alined axially with said score line.
  • a culture collecting package said package including a sealed one-piece ampoule, said ampoule comprising an elongated tubular body having closed ends, a culture-sustaining media contained within said ampoule, and a circumferentially extending score line formed in said body to enable breaking of one end portion of the ampoule away from the other end portion to allow access to said media, said package further including a swab comprising an elongated stern, a swabbing tip on one end of said stem, and a closure for closing the open end of said other end portion of said ampoule after a culture has been collected on said tip and the latter has been placed in said other end portion in contact with said media.

Abstract

A culture collecting swab and a sealed glass ampoule are packaged side-by-side within an envelope. After a culture has been collected on the swab, one end portion of the ampoule is broken off to open the ampoule and permit insertion of the swab into the ampoule and into contact with culture-sustaining media contained in the ampoule.

Description

United States Patent Avery June 17, 1975 [541 CULTURE COLLECTING PACKAGE 3783.104 1/1974 Henshilwood et a1. 195/104 3,783.106 1/1974 Henshilwood H Inventor: Carl Frederick Avery, Rockford, Brown et h k h 4 v n w [73] Assignee: Marion Health and Safety, [nc.,
Rockford, 111. Primary E.\'aminer-A. Louis Monacell Assistant ExaminerC. A. Fan filed Sept' I974 Atmmey, Agent. or Firm-W0lfe, Hubbard. Leydig, [21] App]. No: 509,706 Voit & Osann, Ltd.
[52] US. Cl 195/139; 128/2 W; 195/127 [57] ABSTRACT [51] Int. Cl Cl2k 1/10 [58] Field of Search IIIIIIIIIIIIIIIIII H 95/127, 139, 109; A culture collecting swab and a sealed glass ampoule 23/230 128/2 W are packaged s|de-by-slde within an envelope. After a culture has been collected on the swab, one end por [56] References Cited tion of the ampoule is broken off to open the ampoule and permit insertion of the swab into the ampoule and UNITED STATES PATENTS into contact with culture-sustaining media contained 1450129 (1/1969 Avery Cl 3]. [28/2 in {he gu'npoule 3,579.303 5/1971 Pickering 7 23/230 3,773.035 11/1973 Amnoff et a1. 128/2 W 5 Claims, 6 Drawing Figures CULTURE COLLECTING PACKAGE BACKGROUND OF THE INVENTION This invention relates to devices used by physicians and the like for collecting a culture from various areas of a patients body and for keeping the culture alive for a period of time after it has been collected. Such devices customarily include an absorbent swab upon which the culture is collected by swabbing a particular body area. and further include a container having its own supply of culture-sustaining media. After the culture has been collected. the swab is placed into the container and in contact with the media so as to keep the culture alive until it is subsequently tested. Devices of this general type are disclosed in Pickering US. Pat. No. 3.579.303; Aronoff, et al., US. Pat. No. 3.773.035; Henshilwood. et al.. U.S. Pat. No. 3.783.104 and Henshilwood US Pat. No. 3.783.106.
One of the most commercially successful culture collecting devices is of the type disclosed in Avery, et al., US. Pat. No. 3.450.129. Such a device includes a flexible outer tube within which is retained a frangible glass ampoule having a liquid culture-sustaining media sealed therein. After a culture has been collected on a swab. the latter is placed into the tube and the tube is squeezed to break the ampoule and release the liquid. The liquid moistens an absorbent plug which is disposed within the tube in engagement with the tip of the swab so as to keep the latter moist until the culture is tested.
A large part of the success of the Avery. et al.. culture collecting device is attributable to the fact that the culture-sustaining media is originally sealed within an ampoule made ofglass. The glass ampoule can be easily and effectively sterilized with steam and it does not react either with the culturesustaining media or the culture.
SUMMARY OF THE INVENTION One of the primary aims of the present invention is to provide a new and improved culture collecting device which retains all of the basic advantages of the prior Avery. et al.. device while being simpler in con struction. easier to use. and more readily adaptable to collect and sustain different types of cultures.
A further object is to provide a comparatively simple and inexpensive culture collecting device which may employ either a liquid or solid culture-sustaining media and which is capable of maintaining the culture in a substantially oxygen-free atmosphere.
A more detailed object is to provide a culture collecting device having a unique glass ampoule which not only holds the culture-sustaining media but which also serves as a container for the swab after the culture has been taken. By providing an ampoule of this type. the need for an outer tube and an absorbent plug such as used in the Avery, et al.. device is eliminated completely and yet the advantages accruing from the use of a glass ampoule are retained.
The invention also resides in the novel construction of the ampoule to facilitate the gaining of access to the culture-sustaining media.
These and other objects and advantages of the present invention will become more apparent from the foilowing detailed description when taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. I is a perspective view of a new and improved culture collecting package embodying the novel features of the present invention.
FIG. 2 is a perspective view of the ampoule.
FIG. 3 is a perspective view of the swab.
FIG. 4 is a cross-section taken along the line 4-4 of FIG. 3.
FIG. 5 is a perspective view showing the ampoule being opened to enable access to the culture-sustaining media.
FIG. 6 is a perspective view showing the swab telescoped with the ampoule.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT As shown in the drawings for purposes of illustration. the invention is embodied in a package 10 whose components are used for collecting a bacterial specimen or culture from a patient's body and for maintaining the culture in a live condition until such time as it can be tested. The present invention contemplates the provision ofa culture collecting package having new and improved components which are simpler, less expensive and easier to use than those available heretofore and which are capable of maintaining the collected culture in either a normal or an oxygen-free atmosphere while preserving the culture in either a liquid or solid culturesustaining media.
More specifically, the package 10 includes a swab II and an ampoule 13 which initially are disposed side-byside within an elongated and substantially flat envelope 14. The latter comprises a flexible transparent blister 15 which is releasably sealed to a peel away backing 16. After the swab and the ampoule have been sealed in the envelope. the envelope may be autoclaved in order to sterilize the swab and the outside of the ampoule. The swab and the ampoule may be removed from the envelope by peeling away one end portion of the backing 16 and taking the swab and ampoule out of the opened end of the envelope.
The swab 11 comprises an elongated stem 17 (FIG. 3) made of plastic and having an absorbent swabbing tip 19 such as cotton on one end thereof. After a culture has been collected on the tip, it is necessary to place the tip in contact with a culture-sustaining media 20 in order to keep the culture in a live condition until it reaches a laboratory for testing.
In carrying out the invention. the culture-sustaining media 20 is originally sealed within the ampoule l3 which advantageously is made of glass and which serves as a container for the swab 11 after the culture has been collected. As shown in FIG. 2, the ampoule is of one-piece construction and includes an elongated tubular body 21 having a circular cross-section and having ends which are defined by generally hemi- spherical domes 23 and 24. The culture-sustaining media 20 is disposed within one end portion of the ampoule and. in this instance. is shown as being a liquid such as modified Stuarts transport media. The culture-sustaining media can. however. be a solid substance such as an agar slant which may be located in the end portion of the ampoule either with or without a charcoal filtering substance or other filtering agent. Some cultures can survive and grow only in an oxygen-free atmosphere and thus, in some instances. the ampoule also will be 3 filled with a non-oxidizing and preferably heavienthanair gas such as nitrogen.
After the culture has been collected on the swabbing tip 19, the ampoule 13 is opened to permit the tip to he placed in contact with the media 20. For this purpose. a circumferentially extending score line (FIG 2) is scratched in the outside of the ampoule body 21 adjacent the dome 24, the score line being comparatively short and extending only part way around the circumference of the body. When the ampoule is held as shown in FIG. 5, one end portion of the ampoule may be snapped cleanly away from the other end portion at the break point defined by the short score line 25. After the ampoule has been thus opened, the broken away end portion is discarded and the swab stem 17 is inserted into the longer end portion to place the tip 19 into contact with the media 20 (see FIG. 6). To inform the user as to where to break the ampoule, a band of tape 26 (FIG. 2) with printed instructions may be wrapped around the body 21, the tape having end portions overlapping the end portions of the ampoule and having a perforated tear line 27 alined with the score line 25.
As an incident to inserting the swab stem 17 into the ampoule 13, the open end of the ampoule is closed to keep contaminants out of the ampoule and to prevent the nitrogen or the like from escaping from the ampoule. For this purpose, a closure or cap 30 (FIG. 3) is joined to the end of the stem 17 opposite the tip 19 and is sized to telescope tightly over the open end portion of the ampoule. The cap is made of plastic and includes a series of axially extending ribs 31 (FIG. 4) which are spaced circumferentially around the interior of the cap and which tightly grip the swab stem 17. If the cap is placed quickly on the ampoule just after the latter has been opened, the relatively heavy nitrogen will not escape from the ampoule and no substantial amount of air will enter the ampoule. After being closed by the cap 30, the ampoule 11 may be replaced in the envelope l4 and delivered to the laboratory for testing of the culture on the swab tip 19.
Formation of the ampoule 11 is effected much in the same way as the ampoule disclosed in the aforementioned Avery, et al.. patent. That is. one end portion of the body 21 is flamed over to form the dome 23 and then the culture-sustaining media 20 is inserted into the ampoule along with a nonoxidizing gas if the latter is desired. Thereafter, the other end portion of the body is flamed over to form the dome 24 and seal the media within the ampoule. Filling and sealing of the ampoule are effected under sterile conditions and thus the interior of the ampoule is sterile when the ampoule is packaged in the envelope 14.
From the foregoing, it will be apparent that the present invention brings to the art a new and improved culture collecting device which possesses the basic advan tages of the commercially successful Avery, et al., device presently being marketed and provides several additional advantages. That is, the new device does not require an outer plastic tube nor an absorbent plug. There is no danger of glass fragments from a crushed ampoule collecting on the swab tip or piercing through an outer tube. The new device is capable of using both solid and liquid culture-sustaining media and of maintaining the culture in an oxygen-free atmosphere. Moreover. the cap 30 may be made shorter since the swab ll assumes only a single position within the ampoule 13 rather than a pre-collecting position and a dif ferent post-collecting position as in the case of the swab within the outer tube of the prior Avery. et al., device.
I claim as my invention.
1. A culture collecting package, said package including a sealed one-piece ampoule made of glass, said ampoule having an elongated tubular body of circular cross-section and having domed ends, a culturesustaining media contained within said ampoule, and a circumferentially extending score line formed in said body whereby one end portion of the ampoule may be broken away from the other end portion along said score line to allow access to said media, said package further including a swab comprising an elongated stern, a swabbing tip on one end of said stern. and a closure on the other end of said stem and sized to telescope with and close the open end of said other end portion of said ampoule after a culture has been collected on said tip and the latter has been placed in contact with said media.
2. A culture collecting package as defined in claim 1 including an elongated envelope, said ampoule and said swab being disposed side-by-side within said envelope prior to initial opening of the envelope.
3. A culture collecting package as defined in claim 1 in which said ampoule is filled with a gas which is heavier than air.
4. A culture collecting package as defined in claim I in which said score line extends only part way around the circumference of said body. and further including a flexible band wrapped around said body and covering said score line, one end portion of said band extending around one end portion of said ampoule and the other end portion of said band extending around the other end portion of said ampoule, at least one end portion of said band being secured to the corresponding end portion of said ampoule, and a circumferentially extending tear line formed around said band and alined axially with said score line.
5. A culture collecting package, said package including a sealed one-piece ampoule, said ampoule comprising an elongated tubular body having closed ends, a culture-sustaining media contained within said ampoule, and a circumferentially extending score line formed in said body to enable breaking of one end portion of the ampoule away from the other end portion to allow access to said media, said package further including a swab comprising an elongated stern, a swabbing tip on one end of said stem, and a closure for closing the open end of said other end portion of said ampoule after a culture has been collected on said tip and the latter has been placed in said other end portion in contact with said media.

Claims (5)

1. A CULTURE COLLECTING PACKAGE, SAID PACKAGE INCLUDING A SEALED ONE-PIECE AMPOULE MADE OF GLASS, SAID AMPOULE HAVING AN ELONGATED TUBULAR BODY OF CIRCULAR CROSS-SECTION AND HAVING DOMED ENDS, A CULTURE-SUNTAINING MEDIA CONTAINED WITHIN SAID AMPOULED, AND A CIRCUMFERENTIALLY EXTENDING SCORE LINE FORMED IN SAID BODY WHEREBY ONE END PORTION OF THE AMPOULE MAY BE BROKEN AWAY FROM THE OTHER END PORTION ALONG SAID SCORE LINE TO ALLOW ACCESS TO SAID MEDIA, SAID PACKAGE FURTHER INCLUDING A SWAB COMPRISING AN ELONGATED STEM, A SWABBING TIP ON ONE END OF SAID STEM, AND A CLOSURE ON THE OTHER END OF SAID STEM AND SIZED TO TELESCOPE WITH AND CLOSE THE OPEN END OF SAID OTHER END PORTIONOF SAID AMPOULE AFTER A CULTURE HAS BEEN COLLECTED ON SAID TIP AND THE LATTER HAS BEEN PLACED IN CONTACT WITH SAID MEDIA.
2. A culture collecting package as defined in claim 1 including an elongated envelope, said ampoule and said swab being disposed side-by-side within said envelope prior to initial opening of the envelope.
3. A culture collecting package as defined in claim 1 in which said ampoule is filled with a gas which is heavier than air.
4. A culture collecting package as defined in claim 1 in which said score line extends only part way around the circumference of said body, and further including a flexible band wrapped around said body and covering said score line, one end portion of said band extending around one end portion of said ampoule and the other end portion of said band extending around the other end portion of said ampoule, at least one end portion of said band being secured to the corresponding end portion of said ampoule, and a circumferentially extending tear line formed around said band and alined axially with said score line.
5. A culture collecting package, said package including a sealed one-piece ampoule, said ampoule comprising an elongated tubular body having closed ends, a culture-sustaining media contained within said ampoule, and a circumferentially extending score line formed in said body to enable breaking of one end portion of the ampoule away from the other end portion to allow access to said media, said package further including a swab comprising an elongated stem, a swabbing tip on one end of said stem, and a closure for closing the open end of said other end portion of said ampoule after a culture has been collected on said tip and the latter has been placed in said other end portion in contact with said media.
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Cited By (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4059404A (en) * 1975-03-29 1977-11-22 Battelle-Institute E.V. Swab and method of taking cell smears for diagnostic examination
US4114605A (en) * 1976-11-02 1978-09-19 University Of Alabama In Birmingham Intraoral cup for collecting saliva and method of using the same
US4136680A (en) * 1976-06-04 1979-01-30 Transmed Corp. Self-contained apparatus for collection and maintenance of medical specimen and methods of using same
US4175008A (en) * 1978-06-26 1979-11-20 Bio-Pharmaceutical Packaging Corp. Culture specimen collection and transport package
EP0058008A2 (en) * 1981-02-10 1982-08-18 Canadian Medical Laboratories Limited Device for use in the collection and transportation of medical specimens
US4353868A (en) * 1981-05-29 1982-10-12 Sherwood Medical Industries Inc. Specimen collecting device
US4376634A (en) * 1980-05-30 1983-03-15 Mallinckrodt, Inc. Assay kit having syringe, dilution device and reagents within sealed container
US4409988A (en) * 1973-05-08 1983-10-18 Donald J. Greenspan Apparatus for collecting cultures
US4492305A (en) * 1983-07-08 1985-01-08 Marion Laboratories, Inc. Package for collecting cultures
US4633886A (en) * 1985-05-02 1987-01-06 Bucaro Jr Russell J Device for home detection of cervical and vaginal cancer
US4707450A (en) * 1986-09-25 1987-11-17 Nason Frederic L Specimen collection and test unit
US4720017A (en) * 1982-07-27 1988-01-19 Medical Media Laboratory, Inc. Specimen kits and stopper therefor
US4761379A (en) * 1984-08-09 1988-08-02 Becton, Dickinson And Company Biological specimen collection device
US4803998A (en) * 1986-01-27 1989-02-14 Ncs Diagnostics, Inc. Swab retaining vial cap and method of use
US4838851A (en) * 1986-11-26 1989-06-13 Shabo Alan L Applicator and package therefor
US4856648A (en) * 1987-12-31 1989-08-15 Steri-Oss, Inc. Packaging & installing implants
US4862899A (en) * 1985-05-02 1989-09-05 Bucaro Russell J Kit for home use detection of cervical and vaginal cancer
US4978504A (en) * 1988-02-09 1990-12-18 Nason Frederic L Specimen test unit
US5047207A (en) * 1986-05-20 1991-09-10 Agri-Diagnostics Associates Kit for diagnosing plant diseases
US5078968A (en) * 1988-02-09 1992-01-07 Nason Frederic L Specimen test unit
US5219761A (en) * 1986-05-20 1993-06-15 Agri-Diagnostics Associates Method and a kit for diagnosing plant diseases
US5238649A (en) * 1988-02-09 1993-08-24 Nason Frederic L Specimen test unit
US5266266A (en) * 1988-02-09 1993-11-30 Nason Frederic L Specimen test unit
US5409377A (en) * 1994-02-14 1995-04-25 Mays; Ralph C. Dental post storage and mounting device
US5467780A (en) * 1993-05-04 1995-11-21 Nabai; Hossein Biopsy wound closure device and method
US5616499A (en) * 1992-12-14 1997-04-01 Silliker Laboratories Group, Inc. Culture and transfer device for enhanced recovery and isolation of microorganisms
US5759146A (en) * 1995-08-28 1998-06-02 Kpc/Master's Craft International, Inc. Method and apparatus for making shrink package
US5869003A (en) * 1998-04-15 1999-02-09 Nason; Frederic L. Self contained diagnostic test unit
US5879635A (en) * 1997-03-31 1999-03-09 Nason; Frederic L. Reagent dispenser and related test kit for biological specimens
US5961330A (en) * 1998-04-09 1999-10-05 Sulzer Calcitek Inc. Vial for dental implant delivery system
EP0960825A3 (en) * 1998-05-28 2000-07-19 Becton, Dickinson and Company Blister-type device for transporting biological or chemical samples
US6248294B1 (en) 1998-04-15 2001-06-19 Frederic L. Nason Self contained diagnostic test unit
US6312395B1 (en) * 1999-06-29 2001-11-06 Innovative Genetic Technology Cell collection and transport
US20050023182A1 (en) * 2003-08-01 2005-02-03 Shah Tilak M. Press-flat centrifuge tube and specimen collection assembly comprising same
US20050252998A1 (en) * 2004-05-11 2005-11-17 Garry Tsaur Opening means
US20070181446A1 (en) * 2006-02-06 2007-08-09 Donahoe Ryan M Medical implant package
US20100116069A1 (en) * 2008-11-12 2010-05-13 Eppendorf Ag Container seal with integrated safety arrangement for a sample carrier
WO2011023176A3 (en) * 2009-08-31 2011-04-21 Sarstedt Ag & Co. Swab system
US20110146419A1 (en) * 2008-02-15 2011-06-23 Gonzalez Bernard A Sample acquisition device
US20110179887A1 (en) * 2008-02-15 2011-07-28 Cobian Paul J Sample acquisition device
WO2011130811A1 (en) * 2010-04-19 2011-10-27 Bulcao Palmeira Sandra Regina Tubular appliances for cleaning body orifices
US20150191690A1 (en) * 2014-01-06 2015-07-09 Lawrence Livermore National Security, Llc Compositions and methods for pathogen transport
USD750501S1 (en) 2012-09-11 2016-03-01 Apple Inc. Packaging with accessory
USD788908S1 (en) * 2014-03-14 2017-06-06 Khaled W. Abusaif Swab
US9700397B2 (en) 2015-11-30 2017-07-11 Metal Industries Research & Development Centre Implant carrier, mixing pot, and implant carrier assembly

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US3783104A (en) * 1971-11-12 1974-01-01 Wilson Pharm & Chem Corp Testing and culturing transport system and method of making same
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Cited By (55)

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Publication number Priority date Publication date Assignee Title
US4409988A (en) * 1973-05-08 1983-10-18 Donald J. Greenspan Apparatus for collecting cultures
US4059404A (en) * 1975-03-29 1977-11-22 Battelle-Institute E.V. Swab and method of taking cell smears for diagnostic examination
US4136680A (en) * 1976-06-04 1979-01-30 Transmed Corp. Self-contained apparatus for collection and maintenance of medical specimen and methods of using same
US4114605A (en) * 1976-11-02 1978-09-19 University Of Alabama In Birmingham Intraoral cup for collecting saliva and method of using the same
US4175008A (en) * 1978-06-26 1979-11-20 Bio-Pharmaceutical Packaging Corp. Culture specimen collection and transport package
US4376634A (en) * 1980-05-30 1983-03-15 Mallinckrodt, Inc. Assay kit having syringe, dilution device and reagents within sealed container
EP0058008A3 (en) * 1981-02-10 1983-05-04 Canadian Medical Laboratories Limited Device for use in the collection and transportation of medical specimens
US4387725A (en) * 1981-02-10 1983-06-14 Mull John D Device for use in the collection and transportation of medical specimens
EP0058008A2 (en) * 1981-02-10 1982-08-18 Canadian Medical Laboratories Limited Device for use in the collection and transportation of medical specimens
US4353868A (en) * 1981-05-29 1982-10-12 Sherwood Medical Industries Inc. Specimen collecting device
US4720017A (en) * 1982-07-27 1988-01-19 Medical Media Laboratory, Inc. Specimen kits and stopper therefor
US4492305A (en) * 1983-07-08 1985-01-08 Marion Laboratories, Inc. Package for collecting cultures
EP0131434A1 (en) * 1983-07-08 1985-01-16 MARION LABORATORIES, INC. (a Delaware corporation) Package for collecting cultures
US4761379A (en) * 1984-08-09 1988-08-02 Becton, Dickinson And Company Biological specimen collection device
US4633886A (en) * 1985-05-02 1987-01-06 Bucaro Jr Russell J Device for home detection of cervical and vaginal cancer
US4862899A (en) * 1985-05-02 1989-09-05 Bucaro Russell J Kit for home use detection of cervical and vaginal cancer
US4803998A (en) * 1986-01-27 1989-02-14 Ncs Diagnostics, Inc. Swab retaining vial cap and method of use
US5047207A (en) * 1986-05-20 1991-09-10 Agri-Diagnostics Associates Kit for diagnosing plant diseases
US5219761A (en) * 1986-05-20 1993-06-15 Agri-Diagnostics Associates Method and a kit for diagnosing plant diseases
US4707450A (en) * 1986-09-25 1987-11-17 Nason Frederic L Specimen collection and test unit
US4838851A (en) * 1986-11-26 1989-06-13 Shabo Alan L Applicator and package therefor
US4856648A (en) * 1987-12-31 1989-08-15 Steri-Oss, Inc. Packaging & installing implants
US4978504A (en) * 1988-02-09 1990-12-18 Nason Frederic L Specimen test unit
US5078968A (en) * 1988-02-09 1992-01-07 Nason Frederic L Specimen test unit
US5238649A (en) * 1988-02-09 1993-08-24 Nason Frederic L Specimen test unit
US5266266A (en) * 1988-02-09 1993-11-30 Nason Frederic L Specimen test unit
US5616499A (en) * 1992-12-14 1997-04-01 Silliker Laboratories Group, Inc. Culture and transfer device for enhanced recovery and isolation of microorganisms
US5467780A (en) * 1993-05-04 1995-11-21 Nabai; Hossein Biopsy wound closure device and method
US5409377A (en) * 1994-02-14 1995-04-25 Mays; Ralph C. Dental post storage and mounting device
US5636991A (en) * 1994-02-14 1997-06-10 Mays; Ralph C. Storage and mounting device for a dental retentive pin
US5759146A (en) * 1995-08-28 1998-06-02 Kpc/Master's Craft International, Inc. Method and apparatus for making shrink package
US5879635A (en) * 1997-03-31 1999-03-09 Nason; Frederic L. Reagent dispenser and related test kit for biological specimens
US5961330A (en) * 1998-04-09 1999-10-05 Sulzer Calcitek Inc. Vial for dental implant delivery system
US5869003A (en) * 1998-04-15 1999-02-09 Nason; Frederic L. Self contained diagnostic test unit
US6248294B1 (en) 1998-04-15 2001-06-19 Frederic L. Nason Self contained diagnostic test unit
EP0960825A3 (en) * 1998-05-28 2000-07-19 Becton, Dickinson and Company Blister-type device for transporting biological or chemical samples
US6312395B1 (en) * 1999-06-29 2001-11-06 Innovative Genetic Technology Cell collection and transport
US20050023182A1 (en) * 2003-08-01 2005-02-03 Shah Tilak M. Press-flat centrifuge tube and specimen collection assembly comprising same
US20050252998A1 (en) * 2004-05-11 2005-11-17 Garry Tsaur Opening means
US7451870B2 (en) 2006-02-06 2008-11-18 Zimmer Dental, Inc. Medical implant package with a cap having a cavity
US7770722B2 (en) 2006-02-06 2010-08-10 Zimmer Dental, Inc. Dental implant package including a plug
US20090065376A1 (en) * 2006-02-06 2009-03-12 Donahoe Ryan M Medical implant package
US20070181446A1 (en) * 2006-02-06 2007-08-09 Donahoe Ryan M Medical implant package
US20110179887A1 (en) * 2008-02-15 2011-07-28 Cobian Paul J Sample acquisition device
US20110146419A1 (en) * 2008-02-15 2011-06-23 Gonzalez Bernard A Sample acquisition device
US8677843B2 (en) 2008-02-15 2014-03-25 3M Innovative Properties Company Sample acquisition device
US20100116069A1 (en) * 2008-11-12 2010-05-13 Eppendorf Ag Container seal with integrated safety arrangement for a sample carrier
WO2011023176A3 (en) * 2009-08-31 2011-04-21 Sarstedt Ag & Co. Swab system
WO2011130811A1 (en) * 2010-04-19 2011-10-27 Bulcao Palmeira Sandra Regina Tubular appliances for cleaning body orifices
USD750501S1 (en) 2012-09-11 2016-03-01 Apple Inc. Packaging with accessory
USD781719S1 (en) 2012-09-11 2017-03-21 Apple Inc. Packaging with accessory
US20150191690A1 (en) * 2014-01-06 2015-07-09 Lawrence Livermore National Security, Llc Compositions and methods for pathogen transport
US9243222B2 (en) * 2014-01-06 2016-01-26 Lawrence Livermore National Security, Llc Compositions and methods for pathogen transport
USD788908S1 (en) * 2014-03-14 2017-06-06 Khaled W. Abusaif Swab
US9700397B2 (en) 2015-11-30 2017-07-11 Metal Industries Research & Development Centre Implant carrier, mixing pot, and implant carrier assembly

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