US3904060A - Three barrier closure system for medical liquid container - Google Patents
Three barrier closure system for medical liquid container Download PDFInfo
- Publication number
- US3904060A US3904060A US445834A US44583474A US3904060A US 3904060 A US3904060 A US 3904060A US 445834 A US445834 A US 445834A US 44583474 A US44583474 A US 44583474A US 3904060 A US3904060 A US 3904060A
- Authority
- US
- United States
- Prior art keywords
- set forth
- combination
- tube
- closure
- thermoplastic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2203/00—Decoration means, markings, information elements, contents indicators
- B65D2203/04—Level indicators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0006—Upper closure
- B65D2251/0015—Upper closure of the 41-type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0037—Intermediate closure(s)
- B65D2251/0062—Membrane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0068—Lower closure
- B65D2251/0087—Lower closure of the 47-type
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/03—Medical
Definitions
- a parenteral liquid bottle with a three barrier closure system that 1) has first and second barriers that withstand pressure dilferentials of 10 psi (0.70 Kglcm during and after steam sterilization and (2) all three barriers open easily with manual force.
- the first bar rier is a puncturable diaphragm hermetically sealing off on inner portion of an opening through an inner closure of the bottle
- the second barrier is a peelable foil hermetically sealing off an outer portion of the opening through the inner closure.
- the third barrier is a tortuously vented outer cap that fits over the first two hermetic barriers and is secured to the bottle by a series of manually frangible webs.
- Sterile medical liquid such as parenteral solution is commonly infused into a patients vein from a container hanging above the patient.
- the sterile liquid flows by gravity through a tubular administration set connected at one end to the container and at an opposite end to a venous needle in the patient.
- a triple barrier system has been provided with first and second barriers that withstand pressure differentials during and after steam sterilization and a third barrier attached after steam sterilization, which third barrier protects the first two barriers. All three barriers are easy to open with manual force.
- This inner closure has a dispensing outlet tube with a first hermetic seal at an inner portion and a second hermetic seal at an outer portion.
- a hermetic seal is defined as a seal that will not pass either gas or liquid.
- the third barrier is an enlarged cap, approximately 1% inch (3.81 cm) diameter that fits over the first two hermetic barriers and is sealed to the thermoplastic bottle without exerting any significant sealing pressure on the first and second hermetic seals.
- the third barrier includes a tortuous air vent system for equalizing pressure inside and outside the outer cap so that as temperature and atmospheric pressure change during storage, there is no pressure differential exerted between the outer caps interior and exterior surfaces.
- This outer cap has a series of very thin frangible webs extending across the tortuous air vents.
- the outer cap or third barrier does not form a hermetic seal and is not subjected to stresses from pressure differentials, and since the outer cap is spaced from the first two barriers, these two barriers do not exert an internal force on the outer cap. Thus the webs need be only strong enough to prevent accidental breaking of the cap during storing and handling. Immediately before use the outer cap is simply twisted or cocked to manually break it off to gain access to the two small diameter hermetic seals.
- This triple barrier system provides a hermetically sealed closure that withstands pressure differentials of IO psi and is also easy to open.
- FIG. 1 is a front elevational view of the thermoplastic bottle as it is supplied to the hospitals;
- FIG. 2 is an enlarged perspective view of the outer closure cap showing its vent structure
- FIG. 3 is a perspective view of a top portion of the bottle showing the outer cap removed from the bottle;
- FIG. 4 is an enlarged view of a top portion of the bottle and closure system with the outer cap shown in cross-sectional view;
- FIG. 5 is a further enlarged sectional view showing the vent structure of the outer cap
- FIG. 6 is a front elevational view of a top portion of the bottle closure system showing the outer cap being removed by a cocking motion
- FIG. 7 is an enlarged sectional view of the dispensing tube with the second barrier opened to expose the first barrier.
- FIG. I shows the bottle 1 that has been sterilized and in the condition it is supplied to the hospital.
- the bottle 1 is standing upright on a series of feet, two of which are shown as 2 and 3.
- a recess 4 in a base of the bottle between feet 2 and 3 houses a hinged hanger 5.
- neck 6 At an upper end of the bottle 1 is neck 6 with an external flange 7.
- An outer cap 8 is connected to this flange 7.
- Sealed within the bottle is a sterile medical liquid 9 and sterile air 10.
- a front of the bottle has a label c located between calibrations 60a and 60b.
- the outer cap 8 is shown in more detail in FIG. 2.
- the cap has a top wall 11., a cylindrical side wall 12 and a laterally protruding external brim 13.
- a series of ribs 14 that aid in gripping the cap during its removal.
- a series of circumferential vents l5 and 16 At a juncture between side wall 12 and brim 13 are a series of circumferential vents l5 and 16. Between these vents are a series of frangible web sections, two of which are shown as 17 and 18.
- the nurse or physician grasps the outer cap 8 and with either a twisting motion or a cocking motion breaks off the outer cap 8. This break occurs at the frangible webs, two of which are shown at 17 and 18. When this occurs the brim 13 which is fused to flange 7 remains with the bottle.
- Cap 8 can then be lifted from the bottle as shown in FIG. 3 to expose an inner cap structure of the closure.
- This inner cap structure includes a transverse wall 20 with an upstanding collar portion 21 sealed to a neck of the bottle in a hermetic fusion joint. Integral with the transverse wall 20 and extending upwardly therefrom is a dispensing tube 22 and an additive tube 23. The outer ends of these two tubes are hermetically sealed by a peelable thermoplastic-metal foil 24.
- the structure of the triple barrier closure system is shown in more detail in FIG. 4.
- the triple barrier system will first be described relative to dispensing tube 22.
- the dispensing outlet tube shown generally at 22, includes two tubular sections. First there is an outer tubular support section 32 that is secured at its lower end to transverse wall 20 and secondly there is a sleeve section 30 disposed within and spaced from tubular support section 32.
- the tubular sleeve section and the tubular support section are integrally joined at their upper ends to combine and form the dispensing outlet tube 22.
- the sleeve section 30 is laterally expandible and tapers inwardly to grip a spike of an administration set as it proceeds toward a lower end of sleeve section 30.
- the sleeve section 30 has an inner flange at its upper end that seals to tapered spike 50 prior to puncture of diaphragm 31, so that no liquid will leak from the container.
- a second hermetic barrier is comprised of the laminated thermoplastic-metal foil 24 that seals off the upper end of dispensing tube 22.
- the thermoplastic portion of foil 25 is peelably bonded to the outlet tube.
- the foil 24 is severed into a first section sealed to the outlet tube 22 and a second section 30 of the dispensing tube 22 contains a given mass of air. There is also a mass of air within the bottle below puncturable diaphragm 31.
- Both the first barrier 31 and the second barrier foil 24, are hermetic seals that can withstand pressure differentials of at least 10 psi (0.70Kg/cm without rupturing or forming a bacterial leak.
- the third barrier in FIG. 4 is an enlarged outer cap 8.
- this outer cap 8 has a top wall 11, a cylindrical sidewall 12 and a brim 13 that is fused to flange 7.
- the tortuous vent 15 at a juncture between the sidewall and brim allows air to pass freely in and out of the outer cap as pressures change during storage. This equalizes pressure inside anad outside outer cap 8, so that no extraordinary strain is placed on frangible webs 17 and 18 during the pressure changes.
- the top wall 11 of outer cap 8 is spaced from the first and second hermetic seals there is no strain placed on frangible webs l7 and 18 by the first and second hermetic seals.
- the web as illustrated by 17 and 18 can be very thin with each having a crosssectional area less than 0.0004 in (0.0026 cm).
- the webs need be only strong enough to resist premature breakage during handling and storage. They do not need to withstand pressure differentials during steam sterilization, as do the first and second barriers.
- the large diameter outer cap approximately 1% inch (3.81 cm) in diameter, does not need to be broken loose about its entire circumference. Only the very thin webs, such as 4 to 6 in number, need to be broken for removal of the cap. Thus the opening forces are greatly reduced from a non-vented cap structure, so the nurse or physician can easily break off the outer cap to gain entrance to the two hermetic seals.
- the hermetic seals 31 and 34 are very small in area, each less than one-half inch (L27 cm) in diameter, so that manual rupturing forces at these barriers are concentrated at a precise location. This makes the critical hermetic seals much easier to open than if they were of a large diameter, such as the diameter of the outer cap.
- the tortuous vent of the outer closure is shown in more detail in the enlarged view of FIG. 5.
- the torous nature of this vent resists bacterial transmission, because bacterial growth or movement does not readily progress through a series of sharp angled turns.
- the third barrier of the outer cap is not a hermetic barrier it does provide protection for the first and second hermetic seals and greatly reduces the chance of airborne or water borne bacteria coming in contact with the second hermetic seal (foil 24) prior to opening the outer cap.
- FIG. 5 The details of the air path through tortuous vent 15 is shown in FIG. 5.
- the cylindrical sidewall 12 is spaced slightly from an upstanding collar portion to provide an air path.
- a brim portion 13 of an outer closure 8 is fused to flange 7 at a fusionjoint 21.
- the tortuous vent, shown generally by numeral 15, is formed by a recess 42 that extends partially through sidewall 12.
- sidewall 12 has a slight clearance space 43 for air passage as shown in the dotted line.
- the bottom area of the cylindrical wall 12 does contact flange 7 this would not be an air tight seal and air could still pass cylindrical wall 12 for equalizing pressure inside cap 8 with the air outside of ca 8.
- FIG. 6 shows the preferred cocking motion that tends to break the frangible webs one at a time reducing the force required. This makes opening slightly easier for the nurse or physician. A twisting motion tends to fracture all of the webs at once.
- the foil 24 (second barrier) is peeled back from outlet tube 22. This exposes sleeve section 30 of the outlet tube with its tapered inner wall surface that receives a tubular spike of an administration set.
- Such tubular spike 50 shown in dotted line, punctures the end wall diaphragm 31 (first barrier) after the spike has formed a seal with the inner flange at a top of the sleeve section 30.
- barrier 31 it can be formed with a protrusion 51 formed by a gate in the mold through which plastic is injected into the mold.
- Protrusioon 51 can be located in a center portion of puncturable wall 31 so as not to intefere with a pointed puncturing section of spike S0 in dotted line shown engaging a left edge portion of diaphragm 31 in FIG. 7.
- an integral annular rib that extends below diaphragm 31.
- the bottle After the spike 50 of an administration set has been connected, the bottle is inverted and hung from its hinged hanger 5 for draining the sterile liquid contents in the bottle through the administration set.
- the additive tube 23 also forms a three barrier closure system with the outer cap 8 being the third barrier.
- a puncturable resealable diaphragm 25 forms the first hermetic barrier
- the foil 24 sealed tLthe outer end of additive tube 23 forms the second hermetic barrier.
- the foil 24 is a laminate of a thermoplastic material and an aluminum foil with the thermoplastic material fused to the dispensing outlet tube.
- thermoplastic steam sterilizable medical liquid container having a flange on a neck portion and an inner closure and an outer closure
- the manually frangible section includes an annular venting opening about the outer closure with one or more frangible webs integral with the outer closure and extending across the vent opening.
- the tube is a dispensing outlet tube and includes a spike gripping tubular sleeve.
- the tube includes an annular support section with the spike gripping sleeve disposed within and integrally formed with this annular support section.
- the second hermetic seal is a manually peelable thermoplastic-metal foil bonded to an outer end of the tube.
- outer closure is a cap having a diameter substantially greater than a diameter of the tube section, whereby forces to open the first and second hermetic seals are concentrated in areas substantially smaller than the outer closure.
- the tube is an outlet tube and the inner closure also includes an additive port closed by a puncturable resealable diaphragm separate from the outlet tube and additive medication can be added to the container through this additive port.
- outer closure is a thermoplastic cap and is secured to the container by a plurality of webs each of which has a cross-sectional area less than 0.0004 in (0.0026 cm for easy manual breakage by twisting or cocking the outer cap relative to the container.
- the inner closure has an additive tube
- the first hermetic barrier is a puncturable resealable diaphragm
- the second hermetic barrier is a metalthermoplastic laminate foil, both of which are sealed to the additive tube.
- thermoplastic bottle having a neck with an outlet passage therethrough; an integral thermoplastic flange integral with this neck; an inner closure permanently sealed to the container neck; said inner closure having an outlet tube formed by an annular support section and a spike gripping tubular sleeve integral with and disposed within the annular support section; a puncturable diaphragm integrally formed with the spike gripping sleeve and forming a first hermetic barrier to a dispensing passage that extends through the spike gripping sleeve; a thermoplasticmetal foil having a thermoplastic surface bonded to an outer end of the dispensing tube forming a second hermetic barrier across the dispensing passage through the spike gripping sleeve; an additive tube integrally formed with the inner closure; a puncturable resealable diaphragm sealing off a passage through the additive tube through which additive medications can be injected into the bottle; a hermetic seal
Abstract
Description
Claims (23)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US445834A US3904060A (en) | 1974-02-26 | 1974-02-26 | Three barrier closure system for medical liquid container |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US445834A US3904060A (en) | 1974-02-26 | 1974-02-26 | Three barrier closure system for medical liquid container |
Publications (1)
Publication Number | Publication Date |
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US3904060A true US3904060A (en) | 1975-09-09 |
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ID=23770370
Family Applications (1)
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US445834A Expired - Lifetime US3904060A (en) | 1974-02-26 | 1974-02-26 | Three barrier closure system for medical liquid container |
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US (1) | US3904060A (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2809855A1 (en) * | 1977-03-14 | 1978-09-21 | Baxter Travenol Lab | BREAKABLE CONTAINER LATCH, METHOD FOR MANUFACTURING IT AND CONTAINER EQUIPPED WITH IT |
FR2419877A1 (en) * | 1978-03-13 | 1979-10-12 | Baxter Travenol Lab | PROCESS FOR FORMING A SEAL WHICH CAN BE BROKEN, IN PARTICULAR FOR THE CLOSURE OF BOTTLES |
US4171236A (en) * | 1977-03-14 | 1979-10-16 | Baxter Travenol Laboratories, Inc. | Method of making frangible seal |
USRE31082E (en) * | 1977-03-14 | 1982-11-16 | Baxter Travenol Laboratories, Inc. | Hermetically sealed tamperproof port protector |
US4527703A (en) * | 1982-06-07 | 1985-07-09 | U.S. Clinical Products, Inc. | Flexible sterile closure system for containers |
US4545783A (en) * | 1983-07-11 | 1985-10-08 | Warner-Lambert Company | Rigid medical solution container |
US4598834A (en) * | 1985-02-06 | 1986-07-08 | U.S. Clinical Products, Inc. | Flexible sterile closure system for a container with a side injection port |
US4903855A (en) * | 1988-11-25 | 1990-02-27 | Baxter International Inc. | Closure and port assembly |
US4919949A (en) * | 1988-10-06 | 1990-04-24 | The Pillsbury Co. | Refrigerated dough container |
US6578723B1 (en) | 1997-05-30 | 2003-06-17 | Pharmacy, Inc. | Flexible sealing cover with seal break indicator |
US20050036910A1 (en) * | 2002-07-25 | 2005-02-17 | Zhou David F. | Specimen collection and application apparatus |
US20090054865A1 (en) * | 2004-10-20 | 2009-02-26 | Torsten Brandenburger | Closing cap for containers filled with medical liquids |
US20100018972A1 (en) * | 2008-07-25 | 2010-01-28 | Kao Keng Nye | Device for transferring material |
US20100308056A1 (en) * | 2007-05-24 | 2010-12-09 | Torsten Brandenburger | Closure cap for a container for receiving liquids and in particular an enteral nutrient solution, and container having such a closure cap |
WO2023081991A1 (en) * | 2021-11-13 | 2023-05-19 | Santos Leite Ronaldo | Fixed closure for long-life package with an access for enteral nutrition equipment for use by a closed system |
WO2023081992A1 (en) * | 2021-11-15 | 2023-05-19 | Santos Leite Ronaldo | Fixed closure for long-life package with an access for enteral nutrition device for use by an open or closed system |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2665024A (en) * | 1951-01-15 | 1954-01-05 | Baxter Don Inc | Pharmaceutical closure |
US2812117A (en) * | 1955-03-29 | 1957-11-05 | Abbott Lab | Venoclysis apparatus |
US2851201A (en) * | 1955-02-01 | 1958-09-09 | Edward J Poitras | Automatic vent stopper |
US2944690A (en) * | 1955-10-27 | 1960-07-12 | American Thermos Products Comp | Closure for vacuum insulated vessels |
US3005455A (en) * | 1955-06-24 | 1961-10-24 | Baxter Laboratories Inc | Container closure |
US3215299A (en) * | 1961-09-11 | 1965-11-02 | Baxter Don Inc | Parenteral solution container |
US3313439A (en) * | 1964-12-22 | 1967-04-11 | Allen & Hanburys Ltd | Closures for containers |
US3394431A (en) * | 1964-09-15 | 1968-07-30 | George S. Nalle Jr. | Apparatus for extruding plastic mesh, lace or net fabrics |
US3480172A (en) * | 1968-04-09 | 1969-11-25 | Baxter Laboratories Inc | Reclosed package |
-
1974
- 1974-02-26 US US445834A patent/US3904060A/en not_active Expired - Lifetime
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2665024A (en) * | 1951-01-15 | 1954-01-05 | Baxter Don Inc | Pharmaceutical closure |
US2851201A (en) * | 1955-02-01 | 1958-09-09 | Edward J Poitras | Automatic vent stopper |
US2812117A (en) * | 1955-03-29 | 1957-11-05 | Abbott Lab | Venoclysis apparatus |
US3005455A (en) * | 1955-06-24 | 1961-10-24 | Baxter Laboratories Inc | Container closure |
US2944690A (en) * | 1955-10-27 | 1960-07-12 | American Thermos Products Comp | Closure for vacuum insulated vessels |
US3215299A (en) * | 1961-09-11 | 1965-11-02 | Baxter Don Inc | Parenteral solution container |
US3394431A (en) * | 1964-09-15 | 1968-07-30 | George S. Nalle Jr. | Apparatus for extruding plastic mesh, lace or net fabrics |
US3313439A (en) * | 1964-12-22 | 1967-04-11 | Allen & Hanburys Ltd | Closures for containers |
US3480172A (en) * | 1968-04-09 | 1969-11-25 | Baxter Laboratories Inc | Reclosed package |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2809855A1 (en) * | 1977-03-14 | 1978-09-21 | Baxter Travenol Lab | BREAKABLE CONTAINER LATCH, METHOD FOR MANUFACTURING IT AND CONTAINER EQUIPPED WITH IT |
US4171236A (en) * | 1977-03-14 | 1979-10-16 | Baxter Travenol Laboratories, Inc. | Method of making frangible seal |
USRE31082E (en) * | 1977-03-14 | 1982-11-16 | Baxter Travenol Laboratories, Inc. | Hermetically sealed tamperproof port protector |
FR2419877A1 (en) * | 1978-03-13 | 1979-10-12 | Baxter Travenol Lab | PROCESS FOR FORMING A SEAL WHICH CAN BE BROKEN, IN PARTICULAR FOR THE CLOSURE OF BOTTLES |
US4527703A (en) * | 1982-06-07 | 1985-07-09 | U.S. Clinical Products, Inc. | Flexible sterile closure system for containers |
US4545783A (en) * | 1983-07-11 | 1985-10-08 | Warner-Lambert Company | Rigid medical solution container |
US4598834A (en) * | 1985-02-06 | 1986-07-08 | U.S. Clinical Products, Inc. | Flexible sterile closure system for a container with a side injection port |
US4919949A (en) * | 1988-10-06 | 1990-04-24 | The Pillsbury Co. | Refrigerated dough container |
US4903855A (en) * | 1988-11-25 | 1990-02-27 | Baxter International Inc. | Closure and port assembly |
US6578723B1 (en) | 1997-05-30 | 2003-06-17 | Pharmacy, Inc. | Flexible sealing cover with seal break indicator |
US20050036910A1 (en) * | 2002-07-25 | 2005-02-17 | Zhou David F. | Specimen collection and application apparatus |
US7163514B2 (en) | 2002-07-25 | 2007-01-16 | Alfa Scientific Designs, Inc. | Specimen collection and application apparatus |
US20090054865A1 (en) * | 2004-10-20 | 2009-02-26 | Torsten Brandenburger | Closing cap for containers filled with medical liquids |
US8211081B2 (en) * | 2004-10-20 | 2012-07-03 | Fresenius Kabi Deutschland Gmbh | Closing cap for containers filled with medical liquids |
US20100308056A1 (en) * | 2007-05-24 | 2010-12-09 | Torsten Brandenburger | Closure cap for a container for receiving liquids and in particular an enteral nutrient solution, and container having such a closure cap |
US9150336B2 (en) * | 2007-05-24 | 2015-10-06 | Fresenius Kabi Deutschland Gmbh | Closure cap for a container for receiving liquids and in particular an enteral nutrient solution, and container having such a closure cap |
US20100018972A1 (en) * | 2008-07-25 | 2010-01-28 | Kao Keng Nye | Device for transferring material |
WO2023081991A1 (en) * | 2021-11-13 | 2023-05-19 | Santos Leite Ronaldo | Fixed closure for long-life package with an access for enteral nutrition equipment for use by a closed system |
WO2023081992A1 (en) * | 2021-11-15 | 2023-05-19 | Santos Leite Ronaldo | Fixed closure for long-life package with an access for enteral nutrition device for use by an open or closed system |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: KENDALL MCGAW LABORATORIES, INC., 2525 MCGAW AVENU Free format text: ASSIGNMENT OF ASSIGNORS INTEREST. EFFECTIVE NOVEMBER 26, 1985.;ASSIGNOR:AMERICAN HOSPITAL SUPPLY CORPORATION, A CORP OF IL;REEL/FRAME:004600/0460 Effective date: 19851126 Owner name: KENDALL MCGAW LABORATORIES, INC., A CORP OF OH,CAL Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:AMERICAN HOSPITAL SUPPLY CORPORATION, A CORP OF IL;REEL/FRAME:004600/0460 Effective date: 19851126 |
|
AS | Assignment |
Owner name: WELLS FARGO BANK, N.A. Free format text: SECURITY INTEREST;ASSIGNOR:MCGAW, INC., A CORP. OF OH;REEL/FRAME:005477/0809 Effective date: 19901022 |
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