US3921637A - Inhaler for powdered medicament - Google Patents

Inhaler for powdered medicament Download PDF

Info

Publication number
US3921637A
US3921637A US490469A US49046974A US3921637A US 3921637 A US3921637 A US 3921637A US 490469 A US490469 A US 490469A US 49046974 A US49046974 A US 49046974A US 3921637 A US3921637 A US 3921637A
Authority
US
United States
Prior art keywords
duct
chamber
capsule
medicament
inhaler
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US490469A
Inventor
Annette Bennie
Norman Leonard Reed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consort Medical PLC
Original Assignee
Bespak Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bespak Industries Ltd filed Critical Bespak Industries Ltd
Application granted granted Critical
Publication of US3921637A publication Critical patent/US3921637A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0095—Preventing manual activation in absence of inhalation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medicinal Preparation (AREA)

Abstract

An inhaler for powdered medicaments comprises a housing having a chamber for receiving a capsule containing a dose of the medicament to be dispensed. A duct in the housing has one end open to the atmosphere and the other end of the duct has its outlet in a mouthpiece which may be inserted into the mouth of a user. A passage connects the chamber to the duct and there is a manually operated pump for supplying air under pressure to the chamber. A flow sensor is arranged in the duct and there is a valve to prevent air under pressure and the medicament from entering the duct as well as means to operate the valve to allow air and medicament to enter the duct when the flow sensor detects a user inhaling through the duct. The valve is situated between the pump and the chamber, and the capsule and the chamber are so arranged and dimensioned that all the air supplied by the pump flows through the capsule when the valve is opened.

Description

United States Patent 1191 Bennie et al.
1111 3,921,637 Nov. 25, 1975 ZNHALER FOR POWDERED MEDICAMENT [73] Assignee: Bespak Industries Limited, England [22] Filed: July 22, 1974 [21] Appl. No.: 490,469
[30] Foreign Application Priority Data July 23, 1973 United Kingdom 35003/73 [52] US. Cl. 128/266 [51] Int. Cl A6ll 9/00 [58] Field of Search 128/265, 266, 208, 197,
Primary Examiner-Allen N. Knowle Assistant Examiner-Norman L. Stack, Jr. Attorney, Agent, or Firm-Browne, B'everidge, DeGrandi & Kline [57] ABSTRACT An inhaler for powdered medicaments comprises a housing having a chamber for receiving a capsule containing a dose of the medicament to be dispensed. A duct in the housing has one end open to the atmosphere and the other end of the duct has its outlet in a mouthpiece which may be inserted into the mouth of a user. A passage connects the chamber to the duct and there is a manually operated pump for supplying air under pressure to the chamber. A flow sensor is arranged in the duct and there is a valve to prevent air under pressure and the medicament from entering the [56] References Cited duct as well as means to operate the valve to allow air UNITED STATES PATENTS and medicament to enter the duct when the flow sen- 2 642 063 6/1953 Brown 28/208 X sor detects a user inhaling through the duct. The valve 311551573 11/1964 Fewer 11:11.21: 1 128/266 x is Situated between the P and the chamben and 3,518,992 7/1970 Altounyan et al. 128/208 the capsule and the Chamber are 80 arranged and 3,635,2l9 1/1972 Edward et al... 128/266 mensioned that all the air supplied by the pump flows 3,818,908 6/1974 Phillips 128/208 X through the capsule when the valve is opened. 3,831,606 8/1974 Damani [28/208 X 8 Claims, 3 Drawing Figures 1 I 1 [I I I I I l 1 12 'F,
l I 30 I l I 6 1 J 1 l I I i r 1 I I t v 1 1 a 1 I D .L ll r I ,32 'flu 3 at 6 23 l7 l 2 /6 r ,t'\.
US. Patent Nov. 25, 1975 3,921,637
INHALER FOR POWDERED MEDICAMENT BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to an inhaler for powdered medicaments and is particularly useful in applying powdered medicaments for the relief of respiratory ailments such as asthma.
2. Description of the Prior Art Such devices are known, for example, from US. Pat. No. 3,155,573 (Fowler) which describesa device in which powdered medicament is entrained in a stream of air under pressure, a valve being opened to allow the stream of air and medicament to be released from the device when a user inhales through a mouthpiece.
SUMMARY OF THE INVENTION It is an object of this invention to provide an improved device of this type.
Accordingly the invention provides an inhaler for powdered medicaments comprising a housing having a chamber for receiving a capsule containing a dose of the medicament to be dispensed, a duct in the housing, one end of the duct being open to the atmosphere and the other end of the duct having its outlet in a mouth piece for insertion into the mouth of a user, a passage connecting the chamber to the duct, manually operated pump means for supplying air under pressure to the chamber, a flow sensor arranged in the duct, and valve means to prevent air under pressure and the medicament from entering the duct and means to operate the valve means to allow air and medicament to enter the duct when the flow sensor detects a user inhaling through the duct, in which inhaler the valve means is situated between the pump means and the chamber, and the capsule and the chamber are so arranged and dimensioned that all the air supplied by the pump means flows through the capsule when the valve means is opened.
An advantage of this arrangement is that a very high proportion of the medicament contained in the capsule is administered to the user during one actuation of the device.
In a preferred embodiment, the flow sensor comprises a vane mounted in the duct for pivotal movement and the valve means is mounted on a lever rigidly attached to the vane.
In this case, the vane may pivot about a hinge between the lever and the duct, and the hinge may be adjacent the valve means.
Further, the valve means may be spring urged into the closed position.
An advantage of this preferred arrangement is that the user receives the dose of medicament at the correct point in the inspiratory cycle and this ensures that the inhaled drug is most efficiently utilised.
Preferably the chamber is adpated to receive a sealed capsule containing the medicament and there may be means to puncture the ends of the capsule.
A pin controlled by a sliding member may be provided to pierce one end of the capsule.
There may be a cover for the mouth piece and the cover may be provided with means to pierce the other end of the capsule.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a vertical section through the inhaler;
FIG. 2 is a horizontal section taken on the line 22 of FIG. 1; and FIG. 3 is a plan view of the inhaler.
DESCRIPTION OF THE PREFERRED EMBODIMENT The inhaler comprises a housing 10 in which is formed a cylinder 11. A bellows 12 is mounted in the cylinder 11 and a non-return valve 13 is provided in the wall of the cylinder 11 to allow ingress of air to the bellows.
At the lower end of the cylinder 11 there is formed a block 14 which is recessed-to house one .end of a capsule 15 containing the powdered medicament to be dispensed. The capsule is held in position by means of a retaining member 16 which has a corresponding recess and which is attached by spokes 35 to a mouthpiece 17 which screws on to the housing.
Air will flow from the cylinder 11 to the capsule 15 by means of a passage 18 in the block and then through an inlet passage 19 also in the block. A valve 20 is provided to close off the lower end of the passage 18 in a manner which will be described later.
In order to puncture the ends of the capsule 15 two needles 21 and 22 are provided. The needle 21 is formed as part of a cover 23 for the mouth piece and passes into the capsule through an outlet 24 from the 7 The valve 20 is mounted at one end of a vane 30 piv- I oted about a fulcrum 31. A spring 32 is provided which biasses the valve 20 to close the passageway 18 (FIG. 1 shows the vane in solid lines in its position where the valve is open and in broken lines in its position where the valve is closed).
The vane 30 is situated in an air duct having its inlet in the region 33 in FIG. 1 and having its outlet through holes in the retaining member 16 leading into the mouth piece.
In order to operate the inhaler a capsule 15 is first placed in position and the two ends of the capsule are punctured, first using the needle 21 and then the needle 22. The cover 23 is then removed. Pressure is then applied to the top of the bellows 12 to provide a supply of air under pressure while the valve 20 is closed because of the action of the spring 32. When the user inhales air through the mouth piece 17 flow of air through the duct from the region 33 to the mouth piece moves the vane 30 into the position shown in solid lines in FIG. 1 thus releasing the air under pressure to flow through the capsule 15 and out into the mouth piece taking with it the medicament in the capsule. In this way a thorough purge of the capsule is ensured and the dose of medicament is inhaled by the user. A typical result for the amount of medicament inhaled by the user is 91% of the medicament contained in the capsule.
We claim:
1. An inhaler for powdered medicaments comprising a housing,
a chamber in the housing;
a capsule containing a dose of the medicament to be dispensed, said capsule being located in the chamber;
a duct in the housing, one end of the duct being open to the atmosphere and the other end'of the duct having its outlet in a mouthpiece for insertion into the mouth of a user;
I an outlet passage connecting the chamber to the duct;
manually operated pump means for supplying air under pressure to the chamber;
an inlet passage means connecting the pump means to the chamber to carry all of the air supplied by the pump means into the capsule;
valve means situated between the pump means and the chamber in the inlet passage for preventing air under pressure and medicament from entering the duct;
a flow sensor arranged in a duct; and
said valve means being operable to open in response to the flow sensor means to allow air under pressure and medicament to enter the duct when the flow sensor detects a user inhaling through the duct.
2. An inhaler as claimed in claim 1 in which the flow sensor comprises a movable vane mounted in the duct. valve means situated between the pump means and the chamber in the inlet passage for preventing air under pressure and medicament from entering the duct;
a flow sensor arranged in the duct; and
said valve means being operable to open in response to the flow sensor means to allow air under pressure and medicament to enter the duct when the flow sensor detects a user inhaling through the duct.
3. An inhaler for powdered medicaments comprising a duct in the housing, one end of the duct being open to the atmosphere and the other end of the duct having I 7 its outlet in a mouth piece for insertion into the mouth of a user, a passage connecting the chamber to the duct, manually operated pump means for supplying airunder pressure to the chamber, a vane pivotally mounted in the duct, and valve means to prevent air under pressure and the medicament from entering the duct, the valve means being arranged on a lever rigidly connected to the vane, to allow air and medicament to enter the duct when the vane detects a user inhaling through the duct, in which applicator the valve means is situated between the pump means and the chamber, and the capsule and the chamber are so arranged and dimensioned that all the air supplied by the pump 7 means flows through the capsule when the valve means is opened.
4. An inhaler as claimed in claim 3 in which the vane pivots about a hinge between the lever and the duct, the hinge being adjacent the valve means.
5. An inhaler as claimed in claim 3 in which the valve means is spring urged into the closed position.
6. An inhaler as claimed in claim 3 in which the chamber is adapted to receive a sealed capsule containing the medicament and means are provided topuncture the ends of the capsule. i
7. An inhaler as claimed in claim 6 in which a pin controlled by a sliding member mounted externally of the housing is provided to pierce one end of the capsule.
8. An inhaler as claimed in claim 7 in which a cover is provided for closing the mouth piece when not in use,
the cover being provided with an internally mounted pin to pierce the other end of the capsule.
l =l l

Claims (8)

1. An inhaler for powdered medicaments comprising a housing, a chamber in the housing; a capsule containing a dose of the medicament to be dispensed, said capsule being located in the chamber; a duct in the housing, one end of the duct being open to the atmosphere and the other end of the duct having its outlet in a mouthpiece for insertion into the mouth of a user; an outlet pasSage connecting the chamber to the duct; manually operated pump means for supplying air under pressure to the chamber; an inlet passage means connecting the pump means to the chamber to carry all of the air supplied by the pump means into the capsule;
2. An inhaler as claimed in claim 1 in which the flow sensor comprises a movable vane mounted in the duct. valve means situated between the pump means and the chamber in the inlet passage for preventing air under pressure and medicament from entering the duct; a flow sensor arranged in the duct; and said valve means being operable to open in response to the flow sensor means to allow air under pressure and medicament to enter the duct when the flow sensor detects a user inhaling through the duct.
3. An inhaler for powdered medicaments comprising a housing having a chamber for receiving a capsule containing a dose of the medicament to be dispensed, a duct in the housing, one end of the duct being open to the atmosphere and the other end of the duct having its outlet in a mouth piece for insertion into the mouth of a user, a passage connecting the chamber to the duct, manually operated pump means for supplying air under pressure to the chamber, a vane pivotally mounted in the duct, and valve means to prevent air under pressure and the medicament from entering the duct, the valve means being arranged on a lever rigidly connected to the vane to allow air and medicament to enter the duct when the vane detects a user inhaling through the duct, in which applicator the valve means is situated between the pump means and the chamber, and the capsule and the chamber are so arranged and dimensioned that all the air supplied by the pump means flows through the capsule when the valve means is opened.
4. An inhaler as claimed in claim 3 in which the vane pivots about a hinge between the lever and the duct, the hinge being adjacent the valve means.
5. An inhaler as claimed in claim 3 in which the valve means is spring urged into the closed position.
6. An inhaler as claimed in claim 3 in which the chamber is adapted to receive a sealed capsule containing the medicament and means are provided to puncture the ends of the capsule.
7. An inhaler as claimed in claim 6 in which a pin controlled by a sliding member mounted externally of the housing is provided to pierce one end of the capsule.
8. An inhaler as claimed in claim 7 in which a cover is provided for closing the mouth piece when not in use, the cover being provided with an internally mounted pin to pierce the other end of the capsule.
US490469A 1973-07-23 1974-07-22 Inhaler for powdered medicament Expired - Lifetime US3921637A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB35003/73A GB1479283A (en) 1973-07-23 1973-07-23 Inhaler for powdered medicament

Publications (1)

Publication Number Publication Date
US3921637A true US3921637A (en) 1975-11-25

Family

ID=10372655

Family Applications (1)

Application Number Title Priority Date Filing Date
US490469A Expired - Lifetime US3921637A (en) 1973-07-23 1974-07-22 Inhaler for powdered medicament

Country Status (18)

Country Link
US (1) US3921637A (en)
JP (1) JPS5071195A (en)
AT (1) AT343819B (en)
BE (1) BE817951A (en)
CA (1) CA1027005A (en)
CH (1) CH573254A5 (en)
DE (1) DE2435186A1 (en)
DK (1) DK394274A (en)
ES (1) ES428490A1 (en)
FR (1) FR2238505A1 (en)
GB (1) GB1479283A (en)
IE (1) IE39612B1 (en)
IL (1) IL45314A (en)
IN (1) IN139075B (en)
IT (1) IT1032064B (en)
NL (1) NL7409739A (en)
SE (1) SE7409485L (en)
ZA (1) ZA744673B (en)

Cited By (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4027391A1 (en) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg GAS-FREE INHALATION DEVICE
DE4027390A1 (en) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg GAS-FREE INHALATION DEVICE
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
WO1996009085A1 (en) 1994-09-21 1996-03-28 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US5507281A (en) * 1990-08-30 1996-04-16 Boehringer Ingelheim Kg Device for initiating a mechanical switching operation in synchronism with the breathing
US5542411A (en) * 1989-11-01 1996-08-06 Novo Nordisk A/S Manually operated dispenser for dispensing a predetermined amount of powdered substance
US5546932A (en) * 1992-03-25 1996-08-20 Tebro Sa Powder jet dispenser for medicament inhalation therapies
US5740794A (en) * 1994-09-21 1998-04-21 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US5769070A (en) * 1995-10-12 1998-06-23 Istoria Farmaceutici S.P.A. Device for the treatment of asthmatic patients, suitable for measuring the peak expiratory flow rate and for delivering drugs used in the treatment of asthma
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
DE19720701A1 (en) * 1997-05-16 1998-11-19 Gsf Forschungszentrum Umwelt Device for applying a medicament aerosol via the lungs
WO1999006092A1 (en) * 1997-03-25 1999-02-11 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5921236A (en) * 1995-03-10 1999-07-13 Unisia Jecs Corporation Medicine administering device for nasal cavities
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US5997848A (en) * 1994-03-07 1999-12-07 Inhale Therapeutic Systems Methods and compositions for pulmonary delivery of insulin
US6012454A (en) * 1989-04-28 2000-01-11 Minnesota Mining And Manufacturing Company Dry powder inhalation device
US6029661A (en) * 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6223746B1 (en) * 1998-02-12 2001-05-01 Iep Pharmaceutical Devices Inc. Metered dose inhaler pump
WO2001043800A1 (en) 1999-12-15 2001-06-21 Glaxo Group Limited Inhalation delivery apparatus and method
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US6439227B1 (en) * 2000-09-25 2002-08-27 Microdrug Ag Breath-actuation
US20020134382A1 (en) * 2000-05-10 2002-09-26 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
GB2375309A (en) * 2001-05-10 2002-11-13 Cambridge Consultants An inhaler for aerosolising powdered medicament
WO2002092154A1 (en) * 2001-04-26 2002-11-21 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US20030034033A1 (en) * 2000-06-30 2003-02-20 Medihale Ltd. System and method for aerosol delivery of a drug
US6550477B1 (en) 1995-08-02 2003-04-22 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US20030183230A1 (en) * 2000-08-10 2003-10-02 Nelson Craig Harvey Device for delivering physiologically active agent in powdered form
US6679256B2 (en) 1999-12-17 2004-01-20 Nektar Therapeutics Systems and methods for extracting powders from receptacles
US6679255B2 (en) * 2001-03-01 2004-01-20 Ivo E. Pera Inhaling device for dispensing powdered medicaments contained in a capsule through the respiratory tract
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
WO2004020405A2 (en) 2002-08-30 2004-03-11 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins
US20040077528A1 (en) * 1999-06-29 2004-04-22 Mannkind Corporation Purification and stabilization of peptide and protein pharmaceutical agents
US20040089299A1 (en) * 2000-10-20 2004-05-13 Bonney Stanley George Inhaler
US20040096403A1 (en) * 1995-05-15 2004-05-20 Mannkind Corporation Method for drug delivery to the pulmonary system
US6752147B1 (en) * 1998-01-30 2004-06-22 Hagepharm Gmbh Inhalation apparatus for powder medications
US20040182387A1 (en) * 1999-07-23 2004-09-23 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US20040211419A1 (en) * 2001-05-10 2004-10-28 Eason Stephen William Inhalers
US20050051166A1 (en) * 2002-12-06 2005-03-10 Nektar Therapeutics Aerosolization apparatus with feedback mechanism
US6866039B1 (en) * 2000-10-12 2005-03-15 Bespak Plc Dispensing apparatus
US20050088617A1 (en) * 2003-10-27 2005-04-28 Jen-Chuen Hsieh Method and apparatus for visual drive control
US20050092323A1 (en) * 2003-10-29 2005-05-05 Klaus Frietsch Inhaler
US20050153874A1 (en) * 2004-01-12 2005-07-14 Mannkind Corporation Method of reducing serum proinsulin levels in type 2 diabetics
WO2005072803A1 (en) * 2004-01-16 2005-08-11 Biodel, Inc. Sublingual drug delivery device
US20050263151A1 (en) * 2004-03-05 2005-12-01 Boehringer Ingelheim International Gmbh Powder inhaler having a nozzle with a plurality of channels
US20050279349A1 (en) * 1991-07-02 2005-12-22 Patton John S Method and device for delivering aerosolized medicaments
US20060237010A1 (en) * 2003-06-16 2006-10-26 Rijksuniversiteit Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
US20070020191A1 (en) * 1999-06-29 2007-01-25 Mannkind Corporation Potentiation of glucose elimination
US20070086952A1 (en) * 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
US20070154404A1 (en) * 2004-03-26 2007-07-05 Paolo Colombo Insulin highly respirable microparticles
US20070178141A1 (en) * 2005-09-07 2007-08-02 Bebaas, Inc. Vitamin B12 compositions
US7278419B2 (en) 1993-01-29 2007-10-09 Novo Nordisk A/S Method for treating diabetes mellitus in a patient
US20080035143A1 (en) * 2006-08-14 2008-02-14 Sievers Robert E Human-powered dry powder inhaler and dry powder inhaler compositions
US20080053437A1 (en) * 1999-07-23 2008-03-06 Mannkind Corporation Unit dose capsules and dry powder inhaler
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US20080257337A1 (en) * 2007-04-19 2008-10-23 Denyer Jonathan S H Ventilator Aerosol Delivery
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
WO2008156381A1 (en) * 2007-06-18 2008-12-24 Przedsiebiorstwo Produkcji Inhaler for powder drug administration
WO2009030705A2 (en) * 2007-09-04 2009-03-12 Alfred Von Schuckmann Device for administration of medication in blister packs
US20090095293A1 (en) * 2001-06-15 2009-04-16 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
EP2087918A1 (en) * 2008-02-05 2009-08-12 Boehringer Ingelheim Pharma GmbH & Co. KG Blister piercer
US20090241949A1 (en) * 2008-03-27 2009-10-01 Smutney Chad C Dry powder inhalation system
US20100108058A1 (en) * 2006-10-25 2010-05-06 Mark Glusker Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7718609B2 (en) 2006-04-12 2010-05-18 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7744925B2 (en) 1994-12-02 2010-06-29 Quadrant Drug Delivery Limited Solid dose delivery vehicle and methods of making same
US20100168690A1 (en) * 2006-12-01 2010-07-01 Ubimed L.L.C. Nasal applicator for a nasal fluid aspiration device and nasal fluid aspiration device including said nasal applicator
US7870856B2 (en) * 2006-04-11 2011-01-18 Boehringer Ingelheim International Gmbh Inhaler
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8273330B2 (en) 2002-04-25 2012-09-25 Nektar Therapeutics Particulate materials
US8337895B2 (en) 2000-06-30 2012-12-25 Novartis Ag Spray drying process control of drying kinetics
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
US8609630B2 (en) 2005-09-07 2013-12-17 Bebaas, Inc. Vitamin B12 compositions
US8623817B2 (en) 2008-08-11 2014-01-07 Mannkind Corporation Method of treating diabetes type 2 by administering ultrarapid acting insulin
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
US8802149B2 (en) 1996-12-31 2014-08-12 Novartis Pharma Ag Systems and processes for spray drying hydrophobic and hydrophilic components
WO2014179228A1 (en) * 2013-04-28 2014-11-06 Impel Neuropharma Inc. Medical unit dose container
US8933023B2 (en) 2004-03-12 2015-01-13 Biodel Inc. Rapid acting injectable insulin compositions
WO2015025324A1 (en) * 2013-08-22 2015-02-26 Sipnose Ltd Device to deliver a predetermined amount of a substance to a natural orifice of the body
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
USD752204S1 (en) 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
USD755367S1 (en) 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
US9550036B2 (en) 2011-03-03 2017-01-24 Impel Neuropharma Inc. Nasal drug delivery device
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US9700529B2 (en) 2002-05-03 2017-07-11 Nektar Therapeutics Particulate materials
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US9919117B2 (en) 2011-05-09 2018-03-20 Impel Neuropharma Inc. Nozzles for nasal drug delivery
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US10441733B2 (en) 2012-06-25 2019-10-15 Respira Therapeutics, Inc. Powder dispersion devices and methods
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US11116914B2 (en) 2014-11-09 2021-09-14 Sipnose Ltd. Device and method for aerosolized delivering of substance to a natural orifice of the body
US11278682B2 (en) 2014-11-09 2022-03-22 Sipnose Ltd. Device and method for aerosolized delivery of substance to a natural orifice of the body
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US11471623B2 (en) 2012-02-21 2022-10-18 Respira Therapeutics, Inc. Powder dispersion methods and devices
US11471618B2 (en) 2014-11-09 2022-10-18 Sipnose Ltd. Adjustable dosing delivery and multi sectioned drug compartment

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE46865B1 (en) * 1977-04-29 1983-10-19 Allen & Hanburys Ltd Device for dispensing medicaments
DE3040641A1 (en) * 1980-10-29 1982-05-27 C.H. Boehringer Sohn, 6507 Ingelheim Mouthpiece for aerosol inhalation - with flat and slider for actuation by inspiration
DE3348370C2 (en) * 1982-10-08 2001-10-11 Glaxo Group Ltd Hand-held inhaler for powder or liq. medical inhalants
DE68914932T2 (en) * 1988-10-04 1994-08-11 Univ Johns Hopkins Inhaler for aerosols.
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device
SK280968B6 (en) 1990-03-02 2000-10-09 Glaxo Group Limited Medicament pack for use in an inhalation device
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
YU48707B (en) 1990-03-02 1999-07-28 Glaxo Group Limited Inhalation device
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
US5192548A (en) * 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
DE4027749A1 (en) * 1990-09-01 1992-03-05 Pfeiffer Erich Gmbh & Co Kg Discharge device for powdered medium - has air pump with compressed air stream picking up and ejecting powder
US5287850A (en) * 1991-08-20 1994-02-22 Habley Medical Technology Corporation Timing and velocity controlled powered pharmaceutical inhaler
GB9218937D0 (en) * 1992-09-08 1992-10-21 Norton Healthcare Ltd Medicament dispensing device
EP0692990B1 (en) * 1993-04-06 1998-09-23 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
SE9802398D0 (en) * 1998-07-03 1998-07-03 Astra Pharma Prod Inhalation device
WO2004103445A1 (en) * 2003-05-21 2004-12-02 Jean-Marc Aiache Powder inhalation device
GB0605723D0 (en) 2006-03-23 2006-05-03 3M Innovative Properties Co Powder filling processes
JP6197036B2 (en) 2012-07-19 2017-09-13 アダミス ファーマシューティカルズ コーポレーション Powder feeder

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2642063A (en) * 1948-07-31 1953-06-16 Frederick M Turnbull Inhaler
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
US3518992A (en) * 1966-09-17 1970-07-07 Fisons Pharmaceuticals Ltd Oral inhaler with spring biased,cam driven piercing device
US3635219A (en) * 1968-06-07 1972-01-18 Fisons Pharmaceuticals Ltd Inhalation device
US3818908A (en) * 1972-08-07 1974-06-25 Riker Laboratories Inc Medicament dispenser
US3831606A (en) * 1971-02-19 1974-08-27 Alza Corp Auto inhaler

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2642063A (en) * 1948-07-31 1953-06-16 Frederick M Turnbull Inhaler
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
US3518992A (en) * 1966-09-17 1970-07-07 Fisons Pharmaceuticals Ltd Oral inhaler with spring biased,cam driven piercing device
US3635219A (en) * 1968-06-07 1972-01-18 Fisons Pharmaceuticals Ltd Inhalation device
US3831606A (en) * 1971-02-19 1974-08-27 Alza Corp Auto inhaler
US3818908A (en) * 1972-08-07 1974-06-25 Riker Laboratories Inc Medicament dispenser

Cited By (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6012454A (en) * 1989-04-28 2000-01-11 Minnesota Mining And Manufacturing Company Dry powder inhalation device
US5542411A (en) * 1989-11-01 1996-08-06 Novo Nordisk A/S Manually operated dispenser for dispensing a predetermined amount of powdered substance
DE4027391A1 (en) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg GAS-FREE INHALATION DEVICE
US5347999A (en) * 1990-08-30 1994-09-20 Boehringer Ingelheim Kg Inhalation device free from propellant gas having brush abrading powder from tablet
LT3125B (en) 1990-08-30 1994-12-27 Boehringer Ingelheim Kg Inhalator without propeller gas with foreign air stream
US5507281A (en) * 1990-08-30 1996-04-16 Boehringer Ingelheim Kg Device for initiating a mechanical switching operation in synchronism with the breathing
DE4027390A1 (en) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg GAS-FREE INHALATION DEVICE
US5617845A (en) * 1990-08-30 1997-04-08 Boehringer Ingelheim Kg Inhalation device free from propellent gas
US6681767B1 (en) 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
US20050279349A1 (en) * 1991-07-02 2005-12-22 Patton John S Method and device for delivering aerosolized medicaments
EP0940154B1 (en) * 1991-07-02 2007-04-18 Nektar Therapeutics Device for delivering aerosolized medicaments
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US6029661A (en) * 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
US5546932A (en) * 1992-03-25 1996-08-20 Tebro Sa Powder jet dispenser for medicament inhalation therapies
US6509006B1 (en) 1992-07-08 2003-01-21 Inhale Therapeutic Systems, Inc. Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6921527B2 (en) 1992-07-08 2005-07-26 Nektar Therapeutics Composition for pulmonary administration comprising a drug and a hydrophobic amino acid
US6797258B2 (en) 1992-07-08 2004-09-28 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized macromolecules
US20030185765A1 (en) * 1992-07-08 2003-10-02 Platz Robert M. Composition for pulmonary administration comprising a drug and a hydrophobic amino acid
US20030198601A1 (en) * 1992-07-08 2003-10-23 Platz Robert M. Compositions and methods for the pulmonary delivery of aerosolized medicaments
US7278419B2 (en) 1993-01-29 2007-10-09 Novo Nordisk A/S Method for treating diabetes mellitus in a patient
US7448375B2 (en) 1993-01-29 2008-11-11 Aradigm Corporation Method of treating diabetes mellitus in a patient
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
WO1995011715A1 (en) * 1993-10-26 1995-05-04 Glaxo Wellcome Inc. Dry powder inhaler with an inhalation-activated piston
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US7138141B2 (en) 1994-03-07 2006-11-21 Nektar Therapeutics Dispersible macromolecule compositions and methods for their preparation and use
US7521069B2 (en) 1994-03-07 2009-04-21 Novartis Ag Methods and compositions for pulmonary delivery of insulin
US6737045B2 (en) 1994-03-07 2004-05-18 Nektar Therapeutics Methods and compositions for the pulmonary delivery insulin
US6685967B1 (en) 1994-03-07 2004-02-03 Nektar Therapeutics Methods and compositions for pulmonary delivery of insulin
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US20030215514A1 (en) * 1994-03-07 2003-11-20 Platz Robert M. Dispersible macromolecule compositions and methods for their preparation and use
US6423344B1 (en) 1994-03-07 2002-07-23 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5997848A (en) * 1994-03-07 1999-12-07 Inhale Therapeutic Systems Methods and compositions for pulmonary delivery of insulin
US20040096401A1 (en) * 1994-03-07 2004-05-20 Patton John S. Methods and compositions for the pulmonary delivery of insulin
US6592904B2 (en) 1994-03-07 2003-07-15 Inhale Therapeutic Systems, Inc. Dispersible macromolecule compositions and methods for their preparation and use
US8173168B2 (en) 1994-03-07 2012-05-08 Novartis Pharma Ag Dispersible macromolecule compositions and methods for their preparation and use
US6089228A (en) * 1994-09-21 2000-07-18 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
WO1996009085A1 (en) 1994-09-21 1996-03-28 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US6543448B1 (en) 1994-09-21 2003-04-08 Inhale Therapeutic Systems, Inc. Apparatus and methods for dispersing dry powder medicaments
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
EP1917992A2 (en) 1994-09-21 2008-05-07 Nektar Therapeutics Apparatus and methods for dispersing dry powder medicaments
US5740794A (en) * 1994-09-21 1998-04-21 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US7744925B2 (en) 1994-12-02 2010-06-29 Quadrant Drug Delivery Limited Solid dose delivery vehicle and methods of making same
US7780991B2 (en) 1994-12-02 2010-08-24 Quadrant Drug Delivery Limited Solid dose delivery vehicle and methods of making same
US7785631B2 (en) 1994-12-02 2010-08-31 Quadrant Drug Delivery Limited Solid dose delivery vehicle and methods of making same
US5921236A (en) * 1995-03-10 1999-07-13 Unisia Jecs Corporation Medicine administering device for nasal cavities
US5993783A (en) * 1995-04-14 1999-11-30 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder α1-antitrypsin
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US7097827B2 (en) 1995-04-14 2006-08-29 Inhale Therapeutic Systems, Inc. Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments
US8394414B2 (en) 1995-05-15 2013-03-12 Mannkind Corporation Method for drug delivery to the pulmonary system
US20040096403A1 (en) * 1995-05-15 2004-05-20 Mannkind Corporation Method for drug delivery to the pulmonary system
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US6561186B2 (en) 1995-08-02 2003-05-13 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6550477B1 (en) 1995-08-02 2003-04-22 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5769070A (en) * 1995-10-12 1998-06-23 Istoria Farmaceutici S.P.A. Device for the treatment of asthmatic patients, suitable for measuring the peak expiratory flow rate and for delivering drugs used in the treatment of asthma
US8802149B2 (en) 1996-12-31 2014-08-12 Novartis Pharma Ag Systems and processes for spray drying hydrophobic and hydrophilic components
AU731677B2 (en) * 1997-03-25 2001-04-05 Zhejiang Hisun Pharmaceutical Co. Ltd. Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
WO1999006092A1 (en) * 1997-03-25 1999-02-11 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
DE19720701A1 (en) * 1997-05-16 1998-11-19 Gsf Forschungszentrum Umwelt Device for applying a medicament aerosol via the lungs
US6606989B1 (en) 1997-05-16 2003-08-19 Gsf-Forschungszentrum Fur Umwelt Und Gesundheit Gmbh Precise administration of a medicated aerosol via the lungs
US6752147B1 (en) * 1998-01-30 2004-06-22 Hagepharm Gmbh Inhalation apparatus for powder medications
US6223746B1 (en) * 1998-02-12 2001-05-01 Iep Pharmaceutical Devices Inc. Metered dose inhaler pump
US7422013B2 (en) 1998-06-04 2008-09-09 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US20030209243A1 (en) * 1998-06-04 2003-11-13 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US8161969B2 (en) 1998-06-04 2012-04-24 Novartis Ag Dry powder dispersing apparatus and methods for their use
US20080230058A1 (en) * 1998-06-04 2008-09-25 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
US6546929B2 (en) 1998-06-04 2003-04-15 Inhale Therapeutic Systems, Inc. Dry powder dispersing apparatus and methods for their use
US6901929B2 (en) 1998-06-04 2005-06-07 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US20070020191A1 (en) * 1999-06-29 2007-01-25 Mannkind Corporation Potentiation of glucose elimination
US8889099B2 (en) 1999-06-29 2014-11-18 Mannkind Corporation Methods and compositions for delivering peptides
US20040077528A1 (en) * 1999-06-29 2004-04-22 Mannkind Corporation Purification and stabilization of peptide and protein pharmaceutical agents
US7943178B2 (en) 1999-06-29 2011-05-17 Mannkind Corporation Methods and compositions for delivering peptides
US20110105391A1 (en) * 1999-06-29 2011-05-05 Mannkind Corporation Methods and Compositions for Delivering Peptides
US20100086609A1 (en) * 1999-06-29 2010-04-08 Mannkind Corporation Methods and Compositions for Delivering Peptides
US7648960B2 (en) 1999-06-29 2010-01-19 Mannkind Corporation Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles
US8389470B2 (en) 1999-06-29 2013-03-05 Mannkind Corporation Methods and compositions for delivering peptides
US20080053437A1 (en) * 1999-07-23 2008-03-06 Mannkind Corporation Unit dose capsules and dry powder inhaler
US20040182387A1 (en) * 1999-07-23 2004-09-23 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US8671937B2 (en) 1999-07-23 2014-03-18 Mannkind Corporation Unit dose capsules and dry powder inhaler
US8950397B2 (en) 1999-07-23 2015-02-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US20080190425A1 (en) * 1999-07-23 2008-08-14 Steiner Solomon S Unit dose cartridge and dry powder inhaler
US9061111B2 (en) 1999-07-23 2015-06-23 Mannkind Corporation Unit dose capsules and dry powder inhaler
US8215300B2 (en) 1999-07-23 2012-07-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US8156936B2 (en) 1999-07-23 2012-04-17 Mannkind Corporation Unit dose capsules and dry powder inhaler
EP1473055A2 (en) 1999-12-15 2004-11-03 Glaxo Group Limited Inhalation delivery apparatus and method
WO2001043800A1 (en) 1999-12-15 2001-06-21 Glaxo Group Limited Inhalation delivery apparatus and method
US6679256B2 (en) 1999-12-17 2004-01-20 Nektar Therapeutics Systems and methods for extracting powders from receptacles
US20020134382A1 (en) * 2000-05-10 2002-09-26 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US20050056281A1 (en) * 2000-05-10 2005-03-17 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US7318436B2 (en) 2000-05-10 2008-01-15 Innovative Devices, Llc Medicament container with same side airflow inlet and outlet and method of use
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US6691704B2 (en) * 2000-06-30 2004-02-17 Medihale Ltd. System and method for aerosol delivery of a drug
US8337895B2 (en) 2000-06-30 2012-12-25 Novartis Ag Spray drying process control of drying kinetics
US20030034033A1 (en) * 2000-06-30 2003-02-20 Medihale Ltd. System and method for aerosol delivery of a drug
US7275537B2 (en) * 2000-08-10 2007-10-02 Meridica Limited Device for delivering physiologically active agent in powdered form
US20030183230A1 (en) * 2000-08-10 2003-10-02 Nelson Craig Harvey Device for delivering physiologically active agent in powdered form
US6439227B1 (en) * 2000-09-25 2002-08-27 Microdrug Ag Breath-actuation
US6866039B1 (en) * 2000-10-12 2005-03-15 Bespak Plc Dispensing apparatus
US20040089299A1 (en) * 2000-10-20 2004-05-13 Bonney Stanley George Inhaler
US6679255B2 (en) * 2001-03-01 2004-01-20 Ivo E. Pera Inhaling device for dispensing powdered medicaments contained in a capsule through the respiratory tract
US20030015191A1 (en) * 2001-04-26 2003-01-23 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
WO2002092154A1 (en) * 2001-04-26 2002-11-21 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US7025058B2 (en) 2001-04-26 2006-04-11 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
US20080115785A1 (en) * 2001-05-10 2008-05-22 Vectura Delivery Devices Limited Inhalers
GB2375309A (en) * 2001-05-10 2002-11-13 Cambridge Consultants An inhaler for aerosolising powdered medicament
US7025056B2 (en) 2001-05-10 2006-04-11 Vectura Delivery Devices Limited Assymetric inhaler
US20040211419A1 (en) * 2001-05-10 2004-10-28 Eason Stephen William Inhalers
US20090126732A1 (en) * 2001-06-15 2009-05-21 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US8333193B2 (en) 2001-06-15 2012-12-18 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US8443799B2 (en) 2001-06-15 2013-05-21 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
EP1688134A3 (en) * 2001-06-15 2009-11-18 Otsuka Pharmaceutical Co., Ltd. Dry powder inhaler for transpulmonary administration
US20090095293A1 (en) * 2001-06-15 2009-04-16 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US8273330B2 (en) 2002-04-25 2012-09-25 Nektar Therapeutics Particulate materials
US10945972B2 (en) 2002-05-03 2021-03-16 Nektar Therapeutics Particulate materials
US9700529B2 (en) 2002-05-03 2017-07-11 Nektar Therapeutics Particulate materials
US10188614B2 (en) 2002-05-03 2019-01-29 Nektar Therapeutics Particulate materials
WO2004020405A2 (en) 2002-08-30 2004-03-11 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins
US20050051166A1 (en) * 2002-12-06 2005-03-10 Nektar Therapeutics Aerosolization apparatus with feedback mechanism
US7516741B2 (en) * 2002-12-06 2009-04-14 Novartis Ag Aerosolization apparatus with feedback mechanism
US20060237010A1 (en) * 2003-06-16 2006-10-26 Rijksuniversiteit Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
US7617822B2 (en) 2003-06-16 2009-11-17 Rijksuniversiteit Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
US20050088617A1 (en) * 2003-10-27 2005-04-28 Jen-Chuen Hsieh Method and apparatus for visual drive control
US20050092323A1 (en) * 2003-10-29 2005-05-05 Klaus Frietsch Inhaler
US20050153874A1 (en) * 2004-01-12 2005-07-14 Mannkind Corporation Method of reducing serum proinsulin levels in type 2 diabetics
WO2005072803A1 (en) * 2004-01-16 2005-08-11 Biodel, Inc. Sublingual drug delivery device
US7658721B2 (en) 2004-01-16 2010-02-09 Biodel Inc. Sublingual drug delivery device
AU2005209199B2 (en) * 2004-01-16 2008-09-11 Biodel Inc. Sublingual drug delivery device
US20050263151A1 (en) * 2004-03-05 2005-12-01 Boehringer Ingelheim International Gmbh Powder inhaler having a nozzle with a plurality of channels
US7984713B2 (en) * 2004-03-05 2011-07-26 Boehringer Ingelheim International Gmbh Powder inhaler having a nozzle with a plurality of channels
US8933023B2 (en) 2004-03-12 2015-01-13 Biodel Inc. Rapid acting injectable insulin compositions
US20070154404A1 (en) * 2004-03-26 2007-07-05 Paolo Colombo Insulin highly respirable microparticles
US7625865B2 (en) 2004-03-26 2009-12-01 Universita Degli Studi Di Parma Insulin highly respirable microparticles
US9796688B2 (en) 2004-08-20 2017-10-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US10130685B2 (en) 2004-08-23 2018-11-20 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US20110183901A1 (en) * 2005-03-31 2011-07-28 Mannkind Corporation Superior Control of Blood Glucose in Diabetes Treatment
US8609630B2 (en) 2005-09-07 2013-12-17 Bebaas, Inc. Vitamin B12 compositions
US20070178141A1 (en) * 2005-09-07 2007-08-02 Bebaas, Inc. Vitamin B12 compositions
US10143655B2 (en) 2005-09-14 2018-12-04 Mannkind Corporation Method of drug formulation
US9446001B2 (en) 2005-09-14 2016-09-20 Mannkind Corporation Increasing drug affinity for crystalline microparticle surfaces
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9717689B2 (en) 2005-09-14 2017-08-01 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US20070086952A1 (en) * 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US10130581B2 (en) 2006-02-22 2018-11-20 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US7870856B2 (en) * 2006-04-11 2011-01-18 Boehringer Ingelheim International Gmbh Inhaler
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7718609B2 (en) 2006-04-12 2010-05-18 Biodel Inc. Rapid acting and long acting insulin combination formulations
US20100269819A1 (en) * 2006-08-14 2010-10-28 Sievers Robert E Human Powered Dry Powder Inhaler and Dry Powder Inhaler Compositions
WO2008021451A2 (en) * 2006-08-14 2008-02-21 Aktiv-Dry Llc Human-powered dry powder inhaler and dry powder inhaler compositions
WO2008021451A3 (en) * 2006-08-14 2008-07-24 Aktiv Dry Llc Human-powered dry powder inhaler and dry powder inhaler compositions
US20080035143A1 (en) * 2006-08-14 2008-02-14 Sievers Robert E Human-powered dry powder inhaler and dry powder inhaler compositions
EP2668970A1 (en) 2006-10-25 2013-12-04 Novartis AG Powder dispersion apparatus
US10245394B2 (en) 2006-10-25 2019-04-02 Mark Glusker Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices
US20100108058A1 (en) * 2006-10-25 2010-05-06 Mark Glusker Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices
US8573197B2 (en) 2006-10-25 2013-11-05 Novartis Ag Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices
US20100168690A1 (en) * 2006-12-01 2010-07-01 Ubimed L.L.C. Nasal applicator for a nasal fluid aspiration device and nasal fluid aspiration device including said nasal applicator
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US8371299B2 (en) 2007-04-19 2013-02-12 Respironics Respiratory Drug Delivery Ventilator aerosol delivery
US20080257337A1 (en) * 2007-04-19 2008-10-23 Denyer Jonathan S H Ventilator Aerosol Delivery
WO2008156381A1 (en) * 2007-06-18 2008-12-24 Przedsiebiorstwo Produkcji Inhaler for powder drug administration
WO2009030705A2 (en) * 2007-09-04 2009-03-12 Alfred Von Schuckmann Device for administration of medication in blister packs
WO2009030705A3 (en) * 2007-09-04 2009-06-11 Schuckmann Alfred Von Device for administration of medication in blister packs
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
EP2087918A1 (en) * 2008-02-05 2009-08-12 Boehringer Ingelheim Pharma GmbH & Co. KG Blister piercer
US20090241949A1 (en) * 2008-03-27 2009-10-01 Smutney Chad C Dry powder inhalation system
US10201672B2 (en) 2008-06-13 2019-02-12 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9446133B2 (en) 2008-06-13 2016-09-20 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9339615B2 (en) 2008-06-13 2016-05-17 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9511198B2 (en) 2008-06-13 2016-12-06 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US10751488B2 (en) 2008-06-13 2020-08-25 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US10675421B2 (en) 2008-06-20 2020-06-09 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US8623817B2 (en) 2008-08-11 2014-01-07 Mannkind Corporation Method of treating diabetes type 2 by administering ultrarapid acting insulin
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US10172850B2 (en) 2008-12-29 2019-01-08 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9655850B2 (en) 2008-12-29 2017-05-23 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
US8651104B2 (en) 2010-12-07 2014-02-18 Respira Therapeutics, Inc. Bead-containing dry powder inhaler
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
US9550036B2 (en) 2011-03-03 2017-01-24 Impel Neuropharma Inc. Nasal drug delivery device
US11730903B2 (en) 2011-03-03 2023-08-22 Impel Pharmaceuticals Inc. Nasal drug delivery device
US10507295B2 (en) 2011-03-03 2019-12-17 Impel Neuropharma, Inc. Nasal drug delivery device
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US11007332B2 (en) 2011-05-09 2021-05-18 Impel Neuropharma, Inc. Nozzles for nasal drug delivery
US9919117B2 (en) 2011-05-09 2018-03-20 Impel Neuropharma Inc. Nozzles for nasal drug delivery
US10940278B2 (en) 2011-05-09 2021-03-09 Impel Neuropharma, Inc. Nozzles for nasal drug delivery
US11890412B2 (en) 2011-05-09 2024-02-06 Impel Pharmaceuticals Inc. Nozzles for nasal drug delivery
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US10130709B2 (en) 2011-06-17 2018-11-20 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US10258664B2 (en) 2011-10-24 2019-04-16 Mannkind Corporation Methods and compositions for treating pain
US9610351B2 (en) 2011-10-24 2017-04-04 Mannkind Corporation Methods and compositions for treating pain
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US11471623B2 (en) 2012-02-21 2022-10-18 Respira Therapeutics, Inc. Powder dispersion methods and devices
US10441733B2 (en) 2012-06-25 2019-10-15 Respira Therapeutics, Inc. Powder dispersion devices and methods
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US10537692B2 (en) 2013-04-28 2020-01-21 Impel Neuropharma, Inc. Medical unit dose container
WO2014179228A1 (en) * 2013-04-28 2014-11-06 Impel Neuropharma Inc. Medical unit dose container
US11191910B2 (en) 2013-04-28 2021-12-07 Impel Neuropharma, Inc. Medical unit dose container
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
WO2015025324A1 (en) * 2013-08-22 2015-02-26 Sipnose Ltd Device to deliver a predetermined amount of a substance to a natural orifice of the body
US11383048B2 (en) 2013-08-22 2022-07-12 Sipnose Ltd. Device to deliver a predetermined amount of a substance to a natural orifice of the body
USD752204S1 (en) 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
USD755367S1 (en) 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US11278682B2 (en) 2014-11-09 2022-03-22 Sipnose Ltd. Device and method for aerosolized delivery of substance to a natural orifice of the body
US11116914B2 (en) 2014-11-09 2021-09-14 Sipnose Ltd. Device and method for aerosolized delivering of substance to a natural orifice of the body
US11471618B2 (en) 2014-11-09 2022-10-18 Sipnose Ltd. Adjustable dosing delivery and multi sectioned drug compartment

Also Published As

Publication number Publication date
ATA603174A (en) 1977-10-15
IT1032064B (en) 1979-05-30
IL45314A (en) 1976-12-31
ZA744673B (en) 1976-03-31
IE39612L (en) 1975-01-23
IE39612B1 (en) 1978-11-22
SE7409485L (en) 1975-01-24
IN139075B (en) 1976-05-01
AU7132974A (en) 1976-01-22
DK394274A (en) 1975-03-10
ES428490A1 (en) 1976-11-16
IL45314A0 (en) 1974-10-22
BE817951A (en) 1974-11-18
NL7409739A (en) 1975-01-27
AT343819B (en) 1978-06-26
CH573254A5 (en) 1976-03-15
DE2435186A1 (en) 1975-02-06
CA1027005A (en) 1978-02-28
GB1479283A (en) 1977-07-13
JPS5071195A (en) 1975-06-12
FR2238505A1 (en) 1975-02-21

Similar Documents

Publication Publication Date Title
US3921637A (en) Inhaler for powdered medicament
US3826413A (en) Device for dispensing fluids
US7219664B2 (en) Breath actuated inhaler
US3456645A (en) Inhalation-actuated aerosol dispensing device
AU742962B2 (en) Inhalation apparatus for powder medications
US5069204A (en) Inhaler
US4648393A (en) Breath activated medication spray
US6286506B1 (en) Inhalation device
CN1524001B (en) Nasal devices
US11167097B2 (en) Dry powder inhaler and inhalation actuated mechanism thereof
PT99710B (en) MEDICATION DISTRIBUTION DEVICE
US20070062519A1 (en) Nebulizer
TNSN06367A1 (en) Inhaler device
US6460537B1 (en) Breath-actuated aerosol dispensers
PT2130562E (en) Drug dispenser
SE460098B (en) DOSAGE INHALATOR WITH DOSING UNIT DOSING PHARMACOLOGICAL ACTIVE SUBSTANCE IN SOLUTION
JPS60185564A (en) Inhalator
PT1443997E (en) An inhalation actuated device
JPS6041975A (en) Oxygen inhalator
NO792917L (en) Inhalation-DEVICE.
NO951341L (en) A valve for use with an inhalation device
US20170281886A1 (en) Inhaler
KR970009724B1 (en) Medicament dispensing device
SE8204675L (en) MEDICAL INHALATION ORGANIZATION
NZ726772B2 (en) Dry powder inhaler and inhalation actuated mechanism thereof